### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460



### MEMORANDUM

Date: 03/31/2015 OFFICE OF CHEMICAL SAFETY AND
POLLUTION PREVENTION



### SUBJECT: Fluazifop-P-butyl. Acute and Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessments for the Sweet Potato Label Amendment

and Resulting Increase in Tolerance Level.



### PC Code: 122809 

### DP Barcode: D426145



### Decision No.: 489431 

### Registration No.: NA



### Petition No.: 4F8262 

### Regulatory Action: Label Amendment



### Risk Assessment Type: Dietary 

### Case No.: NA



### TXR No.: NA 

### CAS No.: 79241-46-6



### MRID No.: NA 40 

### CFR: §180.411



### FROM: William H. Donovan, Ph.D., Chemist

# i.J.~**~** •

# o~ Risk Assessment Branch V

Health Effects Division (HED, 7509P)



### THROUGH: Douglas Dotson, Ph.D., Chemist

# ~. 

# fi;t::;μ,.;

Mohsen Sahafeyen, Chemist Dietary Exposure Science Advisory Council (DESAC)



### TO: Banza Djapao, Environmental Protection Specialist Fungicide Herbicide Branch Registration Division



### Executive Summary

Acute and chronic aggregate dietary [food and drinking water] exposure and risk assessments

were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food consumption data from the U.S. Department of Agriculture's (USDA's) National Health and

Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA). The analyses

were conducted in support of a human-health risk assessment for the proposed label amendment offluazifop-P-butyl uses on sweet potato. This memorandum was reviewed by two peer reviewers of the DESAC, per DESAC SOP 2012.1.

Page 1 of21

### Fluazifop-P-buty l Dietary Exposure and Risk Assessment DP Number: 0426145



### Acute Dietary Exposure Assessment

An unrefined acute dietary (food and drinking water) exposure assessment was conducted for all

established and proposed uses of fluazifop-P-butyl. Acute anticipated residues for all

commodities were determined by multiplying tolerance level residues by a metabolite ratio factor

to include metabolites identified as residues of concern for risk assessment. Maximum estimated drinking water concentrations (EDWCs) from the Environmental Fate and Effects Division (EFED) were also included. No percent crop treated (%CT) refinements were utilized 

### (i.e.,

100% CT was assumed for all crops). Default processing factors were used where appropriate.

At the 95th percentile of exposure, the estimated risk is 

### < 14% of the acute population adjusted

dose (aPAD) for females 13-49 years old, the only relevant population subgroup. A food only analysis demonstrated that food is the primary contributor to aggregate (food+ water) dietary

exposure to fluazifop-P-butyl.

Chronic Dietary Exposure Assessment

A partially refined chronic dietary exposure analysis was performed for all established and proposed uses of fluazifop-P-butyl. Mean residue levels from crop field trials with a ratio adjustment for additional metabolites of concern, average percent crop treated estimates, and experimentally determined processing factors were used in these assessments (where available;

otherwise default processing factors were used). The estimated risk is 17% of the chronic population adjusted dose (cPAD) for the U.S. population. The most highly exposed population subgroup was Children 1-2 years old, at 64% cPAD. A food only analysis demonstrated that

food is the primary contributor to aggregate (food+ water) dietary exposme to fluazifop-P-butyl.

Cancer Dietary Exposure Assessment Fluazifop-P-butyl was classified as "Not likely to be carcinogenic to humans." Therefore, no

cancer dietary exposure assessment was required.



### I. Introduction



### Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose that HED has concluded will result in no unreasonable adverse health effects).

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety

factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in

more detail are available on the EPA/pesticides web site: "Available Information on Assessing Exposure from Pesticides, A User's Guide," 21-JUN-2000, web link: http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPP-2007-0780-0001; or see SOP

99.6 (20-AUG-1999).

The most recent dietary risk assessment for fluazifop-P-butyl was conducted by S. Tadayon (09- AUG-2010, D379452).

Page 2 of21Fluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 3 of 21 

### II. Residue Information

Established tolerances for fluazifop

- P

- butyl are listed under 40 CFR 180.411. These v alues form the basis for the residue levels used in the acute analysis with the following exceptions: grape tolerance of 0.01 ppm was increased to 0.03 ppm for harmonization purposes; sweet potato

tolerance of 0.05 ppm was increased to 1.5 ppm as a result of new field trial data reflecting a PHI reduction from 55 days to 14 days; citrus oil tolerance of 30 ppm was reduced to 0.15 ppm based on the results of a citrus processing study; citrus, juice tolerance of 0.06 ppm was reduced to 0.03 ppm based on the r esults of a citrus processing study; and soybean, seed tolerance of 2.5 ppm was increased to 4.0 ppm based on the results of additional soybean trials

. The residues of concern identified by the Metabolism Assessment Review Committee (MARC) are summarized

in Table 1.

Table 1. Fluazifop

- P

- Butyl Residues of Concern in Plants, Livestock, and Water

. Residues of Concern

Matrix For Tolerance Expression For Risk Assessment

Plants Parent and fluazifop acid (free and conjugated) Parent and fluazifop acid (free and conjugated), 5

- trifluoromethyl

- 2

- pyridone, and 2

- (4

- hydroxyphenoxy)propionic acid (free and conjugated)

Livestock Parent and fluazifop acid (free and conjugated) Parent and fluazifop acid (free and conjugated)

Water NA Parent and fluazifop acid



### For plants, the residue of concern for risk assessment includes residues of trifluoromethylpyridone and hydroxyphenoxypropionic acid (free and conjugated) , neither of which are measured by the analytical method (only parent and fluazifop acid (free and conjugated) are determined by the method) . In order to ac count for the additional residues, a

metabolite ratio factor was estimated from the carrot (MRID No. 47681901), endive (MRID No. 47681902), celery (MRID No. 40693102), and soybean (MRID Nos. 419947 01

- 41994703) metabolism studies and applied to tolerance levels (for the acute analysis) or mean residue levels (for the chronic analysis) . Table 2 provides information on how these factors were determined.

Table 2. Determination of Fluazifop

- P

- B utyl Metabolite Ratios from Metabolism Studies.

Residue Carrot Roots Celery Stalk Endive Soybean

%TRR ppm %TRR ppm %TRR ppm %TRR ppm Fluazifop acid & conjugates (FA) 58.7 0.078 39.6 0.032 43.4 0.766 28 3.1

5

- trifluoromethyl

- 2

- pyridone (TMP) 15.0 0.020 2.8 0.003 10.9 0.193

– --

2

- (4

- hydroxyphenoxy) propionic acid & conjugates (HPPA) -- -- 1.1 0.001

- - 25.5 2.8

Metabolite Ratio (MR) a 1.25X 1.12X 1.25X 1.90X

a MR = 1 + (TMP + HPPA)/FA



### For the acute assessment, the most appropriate metabolite ratio was multiplied by the tolerance level to provide the appropriate input residue level. For the chronic assessment, the ratio was multiplied by the average residue level from the field trials t o provide the appropriate inputFluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 4 of 21 

### residue level. These values for raw agricultural commodities (RACs) and drinking water are

summarized in Table 3.

Table 3. Derivation of Raw Agricultural Commodity (RAC) Anticipated Residue Levels

For Acute and Chronic D ietary Analyses of Fluazifop

- P

- B utyl.

RAC Metabolite Ratio

(MR) Acute Analysis (ppm) Chronic Analysis (ppm)

Tolerance AR A 5 FT Avg
. AR C 6

Asparagus 1 .12x 2 3.0 3.36 0.57 0.638

Banana /plantain 1 .9 x 1 0.01 0.019 0.005 0.0095
Bean, dry, seed 1 .9x 1 50 95 5.4 10.26

Beet, sugar, roots 1 .9x 1 0.25 0.475 0.08 0.152

Carrot , roots 1 .25x 4 2.0 2.5 0.03 0.0375

Cattle, goat, hog, horse, sheep NA 0.05 0.05 0.025 0.025

Coffee , bean 1 .9x 1 0.10 0.19 0.05 0.095

Cotton , undelinted seed 1 .9x 1 1.0 1.9 0.096 0.182

Egg NA 0.05 0.05 0.025 0.025

Endive 1.25 x 3 6.0 7.5 0.238 0.298

Fruit, citrus, group 10 1 .9x 1 0.03 0.057 0.015 0.0285

Fruit, stone, group 12 1 .9x 1 0.05 0.095 0.015 0.0285

Grape 1 .9x 1 0.03 0.057 0.005 0.0095

Goat , hog, horse, sheep NA 0.05 0.05 0.025 0.025

Macadamia n ut 1 .9x 0.10 0.19 0.05 0.095

Milk NA 0.05 0.05 0.025 0.025

Onion

, bulb /garlic 1 .25x 4 0.50 0.625 0.03 0.0375

Pecan 1 .9x 1 0.05 0.095 0.025 0.0475

Peanut 1 .9x 1 1.5 2.85 0.40 0.76

Pepper

, nonbell 1 .12x 2 1.0 1.12 0.6 0.672

Poultry NA 0.05 0.05 0.025 0.025

Potato 1 .25x 4 1.0 1.25 0.11 0.138

Rhubarb 1 .12x 2 0.5 0.56 0.19 0.213

Soybean , seed 1 .9x 1 4.0 7 7.6 1.0 1.9

Sweet potato /yam 1 .25x 4 1.5 8 1.88 0.478 0.598

Water NA NA 0.0334 NA 0.0066

1 From s oybean metabolism study.

2 From c elery metabolism study (stalks).

3 From endive metabolism study.

4 From c arrot metabolism study (roots).

5 AR A = MR * Tolerance

6 AR C = MR * FT Avg.

7 Recommended tolerance: D415419, W. Donovan, 18

- JUN

- 2014.

8 Recommended tolerance: M RID 48893201

.



### The residue chemistry database for fluazifop

- P

- butyl includes processing factors as determined in processing studies. For processed commodities showing no residue concentration in comparison to the residue level in the corresponding RAC, no separate tolerance was set and, for the purposes of this assessment, the processing factor was set to one (1). For processed commodities showing residue concentration in comparison to the residue level in theFluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 5 of 21 

### corresponding RAC, a separate tolerance was r ecommended for the processed commodity. For the acute analysis, since tolerance level residues were used, the processing factor was set to one (1) since the empirical factor was already included in the setting of the tolerance level. For the chronic analysis, where mean residues were used, the empirical or default processing factor was included in the analysis. Table 4 summarizes the processing factors and the residue levels used for the processed commodities.

Table 4. Derivation of Processed Commodity (PC) Anticipated Residue Levels

For Acute and Chronic D ietary Analyses of Fluazifop

- P

- B utyl.

PC Metabolite

Ratio Processing

Factor Acute Analysis (ppm) Chronic Analysis (ppm)

Tolerance AR A 4 FT Avg
. AR C 5

Banana /plantain

- dried 1 .9 x 1 3.9 DD 0.01 0.019 0.005 0.0095

Beef, dried NA 1.92 DD 0.05 0.05 0.025 0.025
Beet, sugar, molasses 1 .9x 1 14 EF 3.5 6.65 0.08 0.152

Carrot , juice 1 .25x 3 1 2.0 2.5 0.03 0.0375

Potato , chips 1 .25x 3 3.3 EF 2.0 2.5 0.11 0.138

Potato , granules/flakes 1 .25x 3 6.4 EF 4.0 5.0 0.11 0.138

Potato , flour 1 .25x 3 6.4 6 4.0 6 5.0 0.11 6 0.138

Cotton , oil 1 .9x 1 1.6 EF 1.3 2.47 0.096 0.182

Citrus, juice 1 .9x 1 1 0.03 7 0.057 0.0 15 0.0 285

Citrus, oil 1 .9x 1 5.0 EF 0.1 5 7 0.285 0.0 15 0.0 285

Plum, prune, dried 8 1 .9x 1 1 0.05 0.095 0.015 0.0285

Fruit, stone, juice 1 .9x 1 1 0.05 0.095 0.015 0.0285

Grape, raisin 1 .9x 1 1 0.03 0.057 0.005 0.0095

Grape, juice/wine 1 .9x 1 1 0.03 0.057 0.005 0.0095

Onion

, bulb , dried 1 .25x 3 9 DD 0.50 0.625 0.03 0.0375

Peach, dried 1 .9x 1 1 0.05 0.095 0.015 0.0285

Peanut, butter 1 .9x 1 1.89 DD 1.5 2.85 0.40 0.76

Peanut , oil 1 .9x 1 1 1.5 2.85 0.40 0.76

Pepper

, nonbell, dried 1 .12x 2 1 1.0 1.12 0.6 0.672

Soybean , oil 7 1 .9x 1 2 .3 EF 4.0 7.6 1.0 1.9

Soybean

, flour/soy milk 1 .9x 1 1 4.0 7.6 1.0 1.9

Chickpea, flour 1 .9x 1 1 50 95 5.4 10.26

1 From s oybean metabolism study.

2 From c elery metabolism study (stalks).

3 From c arrot metabolism study (roots).

4 AR A = MR * Tolerance

5 AR C = MR * FT Avg.

6 Translated from potato, granules/flakes.

7 D415419, W. Donovan, 18

- JUN

- 2014.

8 Plum processing study at 10x rate showed <LOQ residues (D319907, S. Kinard, 17

- AUG

- 2005). Thus all stone fruit processed commodity concentration factors were set to 1.

DD DEEM Default processing factor.

EF Empirical processing factor.



### For some plant commodities, no quantifiable residues were found in the field trials. In those cases, the tolerance level was used for the a cute analysis and a value of 1⁄2 LOQ was used for t heFluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 6 of 21 

### chronic analysis. For livestock commodities, the same approach was taken since the tolerance level for all livestock commodities is set at the LOQ of 0.05 ppm.

The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009

, and 2010. Over this 3

- year period, PDP analyzed 1399 samples of catfish for fluazifop

- P

- butyl residues. None of the samples contained detectable residues. As a result, residues in fish were

not included in the assessment.

I I I. Percent Crop Treated I nformation

BEAD provided an updated Screening Level Usage Analysis (SLUA) for fluazifop

- P

- butyl for the reporting years 2004

- 2013 (Memo, J. Alsadek, 27

- MAR

- 2015). BEAD did not provide percent crop treated information for sweet potatoes; thus, 100% CT was assumed for this

amended use. The SLUA run of 13

- MAR

- 2015 is included as an attachment to this memo.

For the acute dietary analysis, 100% crop treated was assumed for all crops.

The following average percent crop treated estimates were used in the chronic dietary risk assessments for the following crops that are currently registered for fluazif op

- P

- butyl : apricots, 2.5%; asparagus, 2.5%; carrots, 15 %; cherries, 1 %; co tton

, 1 %; dry beans/peas. 1% ; garlic, 10 %; grapefruit, 15%; grapes, 2.5 %; nectarines, 1%; onions, 1 0 %; oranges, 2.5 %; peache s, 2.5%; peanuts, 1%; pecans, 1%; peppers, 2.5%; plums, 2.5%; potatoes, 1%, prunes, 2.5 %; soybeans,

2.5% ; and sugar beets, 1% . 100% crop treated was assumed for all other registered crops not

listed above.

IV. Drinki ng Water Data

The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED) in the following memorandum: “Revised Drinking Water Assessment for the Section 3 Registration of Fluazifop

- p

- butyl For Use on bananas, plantains, citrus, grapes, and sugar beets pre

- bloom and post

- bloom ( Wm. J. Shaughnessy, D371093, 05/25/2010 ) and incorporated directly into this dietary assessment. Water residues were incorporated in the DEEM

- FCID into the foo d categories “water, direct, all sources” and “water, indirect, all sources.”

Estim ated drinking water concentrations (EDW Cs) in ground water were modeled using Tier I SCIGROW (version 2.3, dated July 29, 2003) and surface water E DW Cs were modeled usin g Tier II PRZM (Pesticide Root Zone Model; ver. 3.12.2, May 12, 2005) and EXAMS (Exposure Analysis Modeling System; Ver. 2.98.04.06). The results of this analysis are presented in Table

5 . Estimated exposure concentrations re present exposure to fluazifop acid, with assumptions that fluazifop acid may be present in the R or S form or as a mixture of the enantiomers.

For aerial applications the highest surface water E DW Cs reported for peak, 1 in 10 year average, and the 30 year average as estimated by PRZM/EXAMS for all crop use scenarios were 33.4, 6.6 ppb, and 4.4 ppb, respectively. For gr ound applications the highest EDW Cs for peak, 1 in 10 year average, and the 30 year average were 32.1 ppb, 5.8 ppb, and 3.1 ppb, respectively. SCI

-Fluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 7 of 21 

### GROW estimated t he concentration of fluazifop acid in shallow ground water sources to be 1.56 ppb

.

Table 5 . Summary of the highest predicted surface and ground water concentrations for the drinking water assessment for the use of fluazifop

- p

- butyl on bananas, plantain s, citrus, grapes, and sugar beets.

Use Estimated Drinking Water Concentration of Fluazifop

- Acid (  g/L)

Acute or

Peak 1 in 10 year Average

(Noncancer Chronic) 30 year Average (Cancer Chronic) Aerial Applications Surface Water

Bananas & Plantains 33.4 6.2 3.2

Citrus 28.5 5.4 3.7 Grapes 19.8 6.6 4.4 Sugar Beets 13.0 4.8 3.3 Ground Applications Surface Water

Bananas & Plantains 32.1 5.8 2.7

Citrus 27.3 5.1 2.8 Grapes 16.6 5.3 3.1 Sugar Beets 10.6 3.9 2.3

Ground Water

All Uses 1.56 1.56 1.56

V. DEEM

- FCID Program and Consumption Information

Fluazifop

- P

- butyl acute and chronic dietary exposure assessments were conducted using the

DEEM

- FCID, Version 3.16 , which incorporates 2003

- 2008 consumption data from USDA’s

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000

individuals over two non

- consecutive survey days. Foods “as consumed” (e.g., apple pie) are

linked to EPA

- defined food commodities (e.g.

, apples, peeled fruit

- cooked; fresh or N/S; baked;

or whea t flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups

. However , for acute

exposure assessment

, consumption data are retained as individual consumption events. Based on analysis of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is m ost appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children

1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50

- 99 years old.

For a chronic d ietary exposure assessment, an estimate of the residue level in each food or food

form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue in take estimate. The resulting residue intake estimate for each food/food form is summed with the residue intakeFluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 8 of 21 

### estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.

For an acute exposure assessment, individual one

- day food consumption data are used on an

individual

- by

- individual basis. The reported consu mption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values

and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per

- capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for a nalyses performed at all levels of refinement . However, for

deterministic assessments , any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.

VI. Toxicological Information

On May 6, 2004, the Health Effects Division (HED) Hazard Identification Assessment Review Committee (HIARC) reviewed the recommendations of the toxicology reviewer for f luazifop

- butyl

and f luazifop

- P

- butyl with regard to the acute and chronic dietary Refer ence Doses (RfDs) and the toxicological endpoint selection. The potential for increased susceptibility of infants and children from exposure to f

luazifop

- butyl and f

luazifop

- P

- butyl was also evaluated as required by the Food Quality Protecti on Act (FQPA) of 1996 (TXR NO. 0052611; memo dated June 15, 2004 by D. Anderson). The established toxicological doses and endpoints for fluazifop

- P

- butyl are presented in

Table 6 below. These selections are supported by the current fluazifop

- P

- butyl risk assessment

te am.

Table 6 . Summary of Toxicological Dos es and Endpoints for Fluazifop

- P

- B utyl for Use in Dietary Exposure

Assessment

Exposure

Scenario Dose Used in Risk

Assessment, UF Hazard and Exposure

Based FQPA Safety

Factor Study and Toxicological Effects

Acute Dietary (General population including infants and children) An appropriate endpoint attributable to a single dose was not identified in the available studies including the developmental toxicity studies.

Acute Dietary (Females 13

- 49 years of age) NOAEL = 50 mg/kg/day

UF = 100

Acute RfD = 0.50 mg/kg FQPA SF = 1X

aPAD = acute RfD FQPA SF = 0.50 mg/kg/day Developmental Toxicity in rats

. LOAEL = 200 mg/kg/day based on diaphragmatic hernia.

Chronic Dietary (All populations) NOAEL= 0.74 mg/kg/day

UF = 100

Chronic RfD =

0.0074 mg/kg/day FQPA SF = 1X

cPAD = chronic RfD FQPA SF

= 0.0074 mg/kg/day Two

- Generation Reproduction in

rats

. LOAEL = 5.8 mg/kg/day in males

and 7.1 in females based on decreased spleen, testes &Fluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 9 of 21 Table 6 . Summary of Toxicological Dos es and Endpoints for Fluazifop

- P

- B utyl for Use in Dietary Exposure

Assessment

Exposure

Scenario Dose Used in Risk

Assessment, UF Hazard and Exposure

Based FQPA Safety

Factor Study and Toxicological Effects

epididymal weights in males and uterine & pituitary weights in

females.

Cancer “Not likely to be carcinogenic to humans.”



### VII. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds

100% of the PAD. The DEEM

- FCID analyses estimate the dietary exposure and risk of the U.S. population and various population subgroups. The result s reported in Table 7 are for the general U.S. Population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19,

females 13

- 49, adults 20

- 49, and adults 50

- 99 years.

Results of Acute Dietary Exposure and Risk Analysis

The food plus drinking water results of the acute dietary exposure and risk analysis at the 95 th


### percentile of exposure are reported in Table 7 , below. T he unrefined acute dietary risk estimate

is below the Agency’s level of concern (<100 % aPAD) for the only relevant population subgroup, females 13

- 49 years of age ( 1 4 % aPAD)

, at the 95 th 

### exposure percentile. The food

onl y results are presented in Table 8 and demonstrate that the drinking water contribution to total dietary exposure is small compared to food.

Results of Chronic Dietary Exposure and Risk Analysis

The food plus drinking water results of the chronic dietary exposure and risk analysis are reported in the summary table below. The analysis indicates that for all supported commodities and proposed uses, the chronic dietary risk estimates are below the Agency’s level of concern (<1 00 % cPAD) for the U.S. population ( 17 % cPAD) and all population subgroups. The most highly exposed population subgroup in the chronic dietary exposure analysis is C hildren 1

- 2 years of age ( 64 % cPAD). The food only results are presented in Table 8 and de monstrate that the drinking water contribution to total dietary exposure is small compared to the food

contribution

.Fluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 10 of 21 

### Table 7 . Summary of Dietary ( Food and Drinking Water ) Exposure and Risk for Fluazifop

- P

Butyl

.

Population Subgroup Acute Dietary ( 95th Percentile) Chronic Dietary Cancer

Dietary Exposure (mg/kg/day) % aPAD* Dietary Exposure (mg/kg/day) % cPAD* Dietary Exposure (mg/kg/day) Risk

General U.S. Population

NA NA 0.001244 17

NA NA All Infants (<1 year old) 0.001577 21

Children 1

- 2 years old * 0.004756 64

Children 3

- 5 years old 0.003705 50

Children 6

- 12 years old 0.001819 25

Youth 13

- 19 years old 0.0 01104 15

Adults 20

- 49 years old 0.000 897 12

Adults 50

- 99 years old 0.000 916 12

Females 13

- 49 years old * 0.067665 1 4 0.000 893 12
*The subpopulation s with the highest risk estimates

.



### Table 8 . Summary of Dietary (Food Only ) Exposure and Risk for Fluazifop

- P

- Butyl.

Population Subgroup Acute Dietary ( 95th Percentile) Chronic Dietary Cancer

Dietary Exposure (mg/kg/day) % aPAD* Dietary Exposure (mg/kg/day) % cPAD* Dietary Exposure (mg/kg/day) Risk

General U.S. Population

NA NA 0.00 1106 15

N A N A All Infants (<1 year old) 0.00 1220 17

Children 1

- 2 years old * 0.004556 62

Children 3

- 5 years old 0.003537 48

Children 6

- 12 years old 0.00 1698 23

Youth 13

- 19 years old 0.0 01003 14

Adults 20

- 49 years old 0.000 759 10

Adults 50

- 99 years old 0.000 780 11

Females 13

- 49 years old * 0.067118 13 0.000 756 10
*The subpopulation s with the highest risk estimates

.



### VIII. Characterization of Inputs/Outputs

The acute dietary exposure and risk analyses are based on tolerance

- level residues, 100% crop treated assumptions, and default processing factors. Various refinements could be made to the assessments. However, as there are no risk estimates of concern, no refinements were incorporated.

The chronic dietary exposure and risk analyses are based on mean field trial residues, average percent crop treated data as provided by BEAD , a nd empirical processing factors. As such, these analyses may be considered partially refined. At this level of refinement, risk levels are below

HED’s level of concern and thus no further refinements were needed. Should more refinements

be needed in the future, the use of monitoring data may be considered.Fluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 11 of 21 

### IX. Conclusions

Unrefined acute dietary exposure analyses (deterministic) for all use s of fluazifop

- P

- butyl give

risk estimates for the relevant population sub group, females 13

- 49 years old, that are below

HED’s level of concern at the 95 th 

### percentile of exposure. Partially refined chronic dietary exposure analyses for all use s of fluazifop

- P

- butyl give risk estimates for all population subgroups that are below HED’s level of concern.

HED i s confident that the assessment does not underestimate risk to the general U.S. population

or any pop ulation subgroup.

X. List of Attachments

• Acute R esidue Input file

• Acute Results file (Food + Water)

• Acute Results file (Food Only)

• Chronic Residue Input file

• Chronic Results File (Food + Water)

• Chronic Results file (Food Only)

• BEAD SLUAFluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 12 of 21 

### Attachment: Acute Food plus Water Residue Input File

Filename: C: \ Users \ wdonovan \ Documents \ DEEM Version 3.16 \ 122809a 2015.r08

Chemical: Fluazifop

- P

- Butyl RfD(Chronic): .0074 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .5 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day
Date created/last modified: 03

- 30

- 2015/13:11:19 Program ver. 3.16, 03

- 08

- d

----------------------------------- ------------------------------------------------ EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101052000 1A Beet, sugar 0.475000 1.000 1.000 0101052001 1A Beet, sugar

- babyfood 0.475000 1.000 1.000 0101053000 1A Beet, sugar, molasses 6.650000 1.00 0 1.000 0101053001 1A Beet, sugar, molasses

- babyfood 6.650000 1.000 1.000

0101078000 1AB Carrot 2.500000 1.000 1.000

0101078001 1AB Carrot

- babyfood 2.500000 1.000 1.000

0101079000 1AB Carrot, juice 2.500000 1.000 1.000 0103296000 1C Potato, chips 2.500000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 5.000000 1.000 1.000 0103297001 1C Potato, dry (granules/ flakes)

- b 5.000000 1.000 1.000
0103298000 1C Potato, flour 5.000000 1.000 1.000
0103298001 1C Potato, flour

- babyfood 5.000000 1.000 1.000 0103299000 1C Potato, tuber, w/peel 1.250000 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfood 1.250000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 1.250000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 1.250000 1.000 1.000

0103366000 1CD Sweet potato 1.880000 1.000 1.000 0103366001 1CD Sweet potato

- babyfood 1.880000 1.000 1.000
0103406000 1CD Yam, true 1.880000 1.000 1.000

0103407000 1CD Yam bean 1.880000 1.000 1.000
0301165000 3A Garlic, bulb 0.625000 1.000 1.000
0301165001 3A Garlic, bulb

- babyfood 0.625000 1.000 1.000
0301237000 3A Onion, bulb 0.625000 1.000 1.000
0301237001 3A Onion, bulb

- babyfood 0.625000 1.000 1.000
0301238000 3A Onion, bulb, dried 0.625000 9.000 1.000
0301238001 3A Onion, bulb, dried

- babyfood 0.625000 9.000 1.000

04011500 00 4A Endive 7.500000 1.000 1.000

0402322000 4B Rhubarb 0.560000 1.000 1.000 0600347000 6 Soybean, seed 7.600000 1.000 1.000 0600349000 6 Soybean, soy milk 7.600000 1.000 1.000 0600349001 6 Soybean, soy milk

- babyfood or in 7.600000 1.000 1.000 0600350000 6 Soybean, oil 7.600000 2.300 1.000 0600350001 6 Soybean, oil

- babyfood 7.60000 0 2.300 1.000
0603030000 6C Bean, black, seed 95.000000 1.000 1.000
0603032000 6C Bean, broad, seed 95.000000 1.000 1.000 0603034000 6C Bean, cowpea, seed 95.000000 1.000 1.000

060303 5000 6C Bean, great northern, seed 95.000000 1.000 1.000 0603036000 6C Bean, kidney, seed 95.000000 1.000 1.000
0603038000 6C Bean, lima, seed 95.000000 1.000 1.000 0603039000 6C Bean, mung, see d 95.000000 1.000 1.000 0603040000 6C Bean, navy, seed 95.000000 1.000 1.000 0603041000 6C Bean, pink, seed 95.000000 1.000 1.000 0603042000 6C Bean, pinto, seed 95.000000 1.000 1.000 0603098000 6C Chickpea, seed 95.000000 1.000 1.000 0603098001 6C Chickpea, seed

- babyfood 95.000000 1.000 1.000 0603099000 6C Chickpea, flour 95.000000 1.000 1.000
0603182000 6C Guar, seed 95.000000 1.000 1.000
0603182001 6C Guar, seed

- babyfood 95.000000 1.000 1.000
0603203000 6C Lentil, seed 95.000000 1.000 1.000 0603348000 6C Soybean, flour 7.600000 1.000 1.000 0603348001 6C Soybean, flour

- babyfood 7.600000 1.000 1.000 0802272000 8BC Pepper, nonbell 1.120000 1.000 1.000 0802272001 8BC Pepper, nonbell

- babyfood 1.120000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 1.120000 1.000 1.000

1001106000 10A Citron 0.057000 1.000 1.000

1001107000 10A Citrus hybrids 0.057000 1.000 1.000
1001108000 10A Citrus, oil 0.285000 1.000 1.000 1001240000 10A Orange 0.057000 1.000 1.000 1001241000 10A Orange, juice 0.057000 1.000 1.000Fluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 13 of 21 1001241001 10A Orange, juice

- babyfood 0.057000 1.000 1.000 1001242000 10A Orange, peel 0.057000 1.000 1.000 1001369000 10A Tangerine 0.057000 1.000 1.00 0 1001370000 10A Tangerine, juice 0.057000 1.000 1.000 1002197000 10B Kumquat 0.057000 1.000 1.000

1002199000 10B Lemon 0.057000 1.000 1.000

1002200000 10B Lemon , juice 0.057000 1.000 1.000 1002200001 10B Lemon, juice

- babyfood 0.057000 1.000 1.000 1002201000 10B Lemon, peel 0.057000 1.000 1.000

1002206000 10B Lime 0.057000 1.000 1.000 1002207000 10B Lime, juice 0.057000 1.000 1.000 1002207001 10B Lime, juice

- babyfood 0.057000 1.000 1.000 1003180000 10C Grapefruit 0.057000 1.000 1.000 1003181000 10C Grapefruit, juice 0.057000 1.000 1.000

1003307000 10C Pummelo 0.057000 1.000 1.000 1201090000 12A Cherry 0.095000 1.000 1.000 1201090001 12A Cherry

- babyfood 0.095000 1.000 1.000 1201091000 12A Cherry, juice 0.095000 1.000 1.000 1201091001 12A Cherry, juice

- babyfood 0.095000 1.000 1.000 1202012000 12B Apricot 0.095000 1.000 1.000 1202012001 12B Apricot

- babyfood 0.095000 1.000 1.000 1202013000 12B Apricot, dried 0.095000 1.000 1.000 1202014000 12B Apricot, juice 0.095000 1.000 1.000 1202014001 12B Apricot, juice

- babyfood 0.095000 1.000 1.000

1202230000 12B Nectarine 0.095000 1.000 1.000

1202260000 12B Peach 0.095000 1.000 1.000

1202260001 12B Peach

- babyfood 0.095000 1.000 1.000
1202261000 12B Peach, dried 0.095000 1.000 1.000
1202261001 12B Peach, dried

- babyfood 0.095000 1.000 1.000 1202262000 12B Peach, juice 0.095000 1.000 1.000 1202262001 12B Peach, juice

- babyfood 0.095000 1.000 1.000

1203285000 12C Plum 0.095000 1.000 1.000

1203285001 12C Plum

- b abyfood 0.095000 1.000 1.000 1203286000 12C Plum, prune, fresh 0.095000 1.000 1.000 1203286001 12C Plum, prune, fresh

- babyfood 0.095000 1.000 1.000 1203287000 12C Plum, prune, dried 0.095000 1.000 1.000 1203287001 12C Plum, prune, dried

- babyfood 0.095000 1.000 1.000 1203288000 12C Plum, prune, juice 0.095000 1.000 1.000 1203288001 12C Plum, prune, juice

- babyfood 0.095000 1.000 1.0 00 1304175000 13D Grape 0.057000 1.000 1.000 1304176000 13D Grape, juice 0.057000 1.000 1.000 1304176001 13D Grape, juice

- babyfood 0.057000 1.000 1.000

1304179000 13D Grape, wine and sherry 0.057000 1.000 1.000

1400213000 14 Macadamia nut 0.190000 1.000 1.000

1400269000 14 Pecan 0.095000 1.000 1.000
2003128000 20C Cottonseed, oil 2.470000 1.000 1.000
2003128001 20C Cottonseed, oil

- babyfood 2.470000 1.000 1.000
3100044000 31 Beef, meat 0.050000 1.000 1.000
3100044001 31 Beef, meat

- babyfood 0.050000 1.00 0 1.000
3100045000 31 Beef, meat, dried 0.050000 1.920 1.000 3100046000 31 Beef, meat byproducts 0.050000 1.000 1.000 3100046001 31 Beef, meat byproducts

- babyfood 0.050000 1.000 1.000

3100047000 31 Beef, fat 0.050000 1.000 1.000
3100047001 31 Beef, fat

- babyfood 0.050000 1.000 1.000 3100048000 31 Beef, kidney 0.050000 1.000 1.000
3100049000 31 Beef, liver 0.050000 1.000 1.000
3100049001 31 Beef, liver

- babyfood 0.050000 1.000 1.000
3200169000 32 Goat, meat 0.050000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.050000 1. 000 1.000
3200171000 32 Goat, fat 0.050000 1.000 1.000 3200172000 32 Goat, kidney 0.050000 1.000 1.000
3200173000 32 Goat, liver 0.050000 1.000 1.000

3300189000 3 3 Horse, meat 0.050000 1.000 1.000
3400290000 34 Pork, meat 0.050000 1.000 1.000
3400290001 34 Pork, meat

- babyfood 0.050000 1.000 1.000
3400291000 34 Pork, skin 0.050000 1.000 1.000 3400292000 34 Pork, meat byproducts 0.050000 1.000 1.000 3400292001 34 Pork, meat byproducts

- babyfood 0.050000 1.000 1.000
3400293000 34 Pork, fat 0.050000 1.000 1.000
3400293001 34 Pork, fat

- babyfood 0.050000 1.000 1.000 3400294000 34 Pork, kidney 0.050000 1.000 1.000Fluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 14 of 21 3400295000 34 Pork, liver 0.050000 1.000 1.000

3500339000 35 Sheep, meat 0.050000 1.000 1.000 3500339001 35 Sheep, meat

- babyfood 0.050000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.050000 1.000 1.000 3500341000 35 Sheep, fat 0.050000 1.000 1.000 3500341001 35 Sheep, fat

- babyfood 0.050000 1.000 1.000 3500342000 35 Sheep, kidney 0.050000 1.000 1.000 3500343000 35 Sheep, liver 0.050000 1.000 1.000
3600222000 36 Milk, fat 0.050000 1.000 1.000
3600222001 36 Milk, fat

- baby food/infant formu 0.050000 1.000 1.000
3600223000 36 Milk, nonfat solids 0.050000 1.000 1.000

36002230 01 36 Milk, nonfat solids

- baby food/in 0.050000 1.000 1.000
3600224000 36 Milk, water 0.050000 1.000 1.000
3600224001 36 Milk, water

- babyfood/infant form 0.050000 1.000 1.000
3600225001 36 Milk, sugar (lact ose)

- baby food/ 0.050000 1.000 1.000
4000093000 40 Chicken, meat 0.050000 1.000 1.000
4000093001 40 Chicken, meat

- babyfood 0.050000 1.000 1.000
4000094000 40 Chicken, liver 0.05000 0 1.000 1.000 4000095000 40 Chicken, meat byproducts 0.050000 1.000 1.000 4000095001 40 Chicken, meat byproducts

- babyfoo 0.050000 1.000 1.000
4000096000 40 Chicken, fat 0.050000 1.000 1.000

400009 6001 40 Chicken, fat

- babyfood 0.050000 1.000 1.000
4000097000 40 Chicken, skin 0.050000 1.000 1.000
4000097001 40 Chicken, skin

- babyfood 0.050000 1.000 1.000 5000382000 50 Turkey, meat 0.050000 1.000 1.000 5000382001 50 Turkey, meat

- babyfood 0.050000 1.000 1.000 5000383000 50 Turkey, liver 0.050000 1.000 1.000 5000383001 50 Turkey, liver

- babyfood 0.050000 1.000 1.000 5000384000 50 Turkey, meat byproducts 0.050000 1.000 1.000 5000384001 50 Turkey, meat byproducts

- babyfood 0.050000 1.000 1.000 5000385000 50 Turkey, fat 0.050000 1 .000 1.000 5000385001 50 Turkey, fat

- babyfood 0.050000 1.000 1.000 5000386000 50 Turkey, skin 0.050000 1.000 1.000 5000386001 50 Turkey, skin

- babyfood 0.050000 1.000 1.000

6000301000 60 Poultry, other, meat 0.050000 1.000 1.000 6000302000 60 Poultry, other, liver 0.050000 1.000 1.000 6000303000 60 Poultry, other, meat byproducts 0.050000 1.000 1.000 6000304000 60 Poultry, other, fat 0.050000 1.000 1.000 6000305000 60 Poultry, other, skin 0.050000 1.000 1.000 7000145000 70 Egg, whole 0.050000 1.000 1.000 7000145001 70 Egg, whole

- babyfood 0.050000 1.000 1.000 7000146000 70 Egg, white 0.050000 1.000 1.000 7000146001 70 Egg, white (solids)

- babyfood 0.050000 1.000 1.000 7000147000 70 Egg, yolk 0.050000 1.000 1.000

700014700 1 70 Egg, yolk

- babyfood 0.050000 1.000 1.000
8601000000 86A Water, direct, all sources 0.033400 1.000 1.000
8602000000 86B Water, indirect, all sources 0.033400 1.000 1.000 9500019000 O Asparagus 3.360000 1.000 1.000

9500023000 O Banana 0.019000 1.000 1.000

9500023001 O Banana

- babyfood 0.019000 1.000 1.000
9500024000 O Banana, dried 0.019000 3.900 1.000
9500024001 O Banana, dried

- babyfood 0.019000 3.900 1.000
9500115000 O Coffee, roasted bean 0.190000 1.000 1.000
9500116000 O Coffee, instant 0.190000 1.000 1.000

9500177 000 O Grape, leaves 0.057000 1.000 1.000 9500178000 O Grape, raisin 0.057000 1.000 1.000

9500263000 O Peanut 2.850000 1.000 1.000
9500264000 O Peanut, butter 2.850000 1.890 1.000
9500265000 O Peanut, oil 2.850000 1.000 1.000

9500283000 O Plantain 0.019000 1.000 1.000
9500284000 O Plantain, dried 0.019000 3.900 1.000Fluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 15 of 21 

### Attachment : Acute Results File (Food + Water)

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for FLUAZIFOP

- P

- BUTYL NHANES 2003

- 2008 2

- Day Residue file: 122809a 2015.r08 Adjustment factor #2 NOT used. Analysis Date: 03

- 30

- 2015/13:12:56 Residue file dated: 03

- 30

- 2015/13:11:19
RAC/FF intake summed over 24 hours

Run Comment: "food and water"

========================= ======================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Female 13

- 49:

0.067665 13.53 0.134148 26.83 0.277261 55.45



### Attachment : Acute Results File (Food Only)

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for FLUAZIFOP

- P

- BUTYL NHANES 2003

- 2008 2

- Day Residue file: 122809afood 2015.r08 Adjustment factor #2 NOT used. Analysis Date: 03

- 30

- 2015/13:17:02 Residue file dated: 03

- 30

- 2015/13:15:12
RAC/FF intake summed over 24 hours
Run Comment: "food only"

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percenti le 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Female 13

- 49:

0.067118 13.42 0.133344 26.6 7 0.277179 55.44Fluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 16 of 21 

### Attachment: Chronic Food plus Water Residue Input File

Filename: C: \ Users \ wdonovan \ Documents \ DEEM Version 3.16 \ 122809c 2015.r08 Chemical: Fluazifop

- P

- Butyl RfD(Chronic): .0074 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD( Acute): .5 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day
Date created/last modified: 03

- 30

- 2015/12:09:19 Program ver. 3.16, 03

- 08

- d

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101052000 1A Beet, sugar 0.152000 1.000 0.010 0101052001 1A Beet, sugar

- babyfood 0.152000 1.000 0.010 0101053000 1A Beet, sugar, molasses 0.152000 14.000 0.010 0101053001 1A Beet, sugar, molasses

- babyfood 0.152000 14.000 0.010

0101078000 1AB Carrot 0.037500 1.000 0.150

0101078001 1AB Carrot

- babyfood 0.037500 1.000 0.150 0101079000 1AB Carrot, juice 0.037500 1.000 0.150
0103296000 1C Potato, chips 0.138000 3.300 0.010 0103297000 1C Potato, dry (granules/ flakes) 0.138000 6.400 0.010 0103297001 1C Potato, dry (granules/ flakes)

- b 0.138000 6.400 0.010
0103298000 1C Potato, flour 0.138000 6.400 0.010
0103298001 1C Potato, flour

- babyfood 0.138000 6.400 0.010 0103299000 1C Potato, tuber, w/peel 0.138000 1.000 0.010
0103299001 1C Potato, t uber, w/peel

- babyfood 0.138000 1.000 0.010 0103300000 1C Potato, tuber, w/o peel 0.138000 1.000 0.010 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.138000 1.000 0.010 0103366000 1CD Sweet potato 0.598000 1.000 1.000 0103366001 1CD Sweet potato

- babyfood 0.598000 1.000 1.000
0103406000 1CD Yam, true 0.598000 1.000 1.000

0103407000 1CD Yam bean 0.598000 1.000 1.000
0301165000 3A Garlic, bulb 0.037500 1.000 0.100
0301165001 3A Garlic, bulb

- babyfood 0.037500 1.000 0.100
0301237000 3A Onion, bulb 0.037500 1.000 0.100
0301237001 3A Onion, bulb

- babyfood 0.037500 1.000 0.100
0301238000 3A Onion, bulb, dried 0.037500 9.000 0.100
0301238001 3A Onion, bulb, dried

- babyfood 0.037500 9.000 0.100

0401150000 4A Endive 0.298000 1.000 1.000

0402322000 4B Rhubarb 0.213000 1.000 1.000 0600347000 6 Soybean, seed 1.900000 1.000 0.025 0600349000 6 Soybean, soy milk 1.900000 1.000 0.02 5 0600349001 6 Soybean, soy milk

- babyfood or in 1.900000 1.000 0.025 0600350000 6 Soybean, oil 1.900000 2.300 0.025 0600350001 6 Soybean, oil

- babyfood 1.900000 2.300 0.025
0603030000 6C Bean, black, seed 10.260000 1.000 0.010
0603032000 6C Bean, broad, seed 10.260000 1.000 0.010 0603034000 6C Bean, cowpea, seed 10.260000 1.000 0.010 0603035000 6C Bean, great northern, seed 10.260000 1.000 0.010 0603036000 6C Bean, kidney, seed 10.260000 1.000 0.010
0603038000 6C Bean, lima, seed 10.260000 1.000 0.010 0603039000 6C Bean, mung, seed 10.260000 1.000 0.010 0603040000 6C Bean, navy, seed 10.260000 1.000 0.010 0603041000 6C Bean, pink, seed 10.260000 1.000 0.010 0603042000 6C Bean, pinto, seed 10.260000 1.000 0.010

0603098000 6C C hickpea, seed 10.260000 1.000 0.010 0603098001 6C Chickpea, seed

- babyfood 10.260000 1.000 0.010 0603099000 6C Chickpea, flour 10.260000 1.000 0.010
0603182000 6C Guar, seed 10.260000 1.000 0.010
0603182001 6C Guar, seed

- babyfood 10.260000 1.000 0.010
0603203000 6C Lentil, seed 10.260000 1.000 0.010 0603348000 6C Soybean, flour 1.900000 1.000 0.025 0603348001 6C Soybean, flour

- babyfood 1.900000 1.000 0.025 0802272000 8BC Pepper, nonbell 0.672000 1.000 0.025 0802272001 8BC Pepper, nonbell

- babyfood 0.672000 1.000 0.025

0802273000 8BC Pepper, nonbell, dried 0.672000 1.000 0.025

1001106000 10A Citron 0.028500 1.000 1.000 1001107000 10A Citrus hybrids 0.028500 1.000 1.000
1001108000 10A Citrus, oil 0.028500 5.000 1.000 1001240000 10A Orange 0.028500 1.000 25.000 1001241000 10A Orange, juice 0.028500 1.000 25.000Fluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 17 of 21 1001241001 10A Orange, juice

- babyfood 0.028500 1.0 00 25.000 1001242000 10A Orange, peel 0.028500 1.000 25.000 1001369000 10A Tangerine 0.028500 1.000 1.000 1001370000 10A Tangerine, juice 0.028500 1.000 1.000

1002197000 10 B Kumquat 0.028500 1.000 1.000

1002199000 10B Lemon 0.028500 1.000 1.000 1002200000 10B Lemon, juice 0.028500 1.000 1.000 1002200001 10B Lemon, juice

- babyfood 0.028500 1.000 1.000 1002201000 10B Lemon, peel 0.028500 1.000 1.000

1002206000 10B Lime 0.028500 1.000 1.000

1002207000 10B Lime , juice 0.028500 1.000 1.000 1002207001 10B Lime, juice

- babyfood 0.028500 1.000 1.000 1003180000 10C Grapefruit 0.028500 1.000 0.150 1003181000 10C Grapefruit, juice 0.028500 1.000 0.150

1003307000 10C Pummelo 0.028500 1.000 1.000 1201090000 12A Cherry 0.028500 1.000 0.010 1201090001 12A Cherry

- babyfood 0.028500 1.000 0 .010 1201091000 12A Cherry, juice 0.028500 1.000 0.010 1201091001 12A Cherry, juice

- babyfood 0.028500 1.000 0.010 1202012000 12B Apricot 0.028500 1.000 0.025 1202012001 12B Ap ricot

- babyfood 0.028500 1.000 0.025 1202013000 12B Apricot, dried 0.028500 1.000 0.025 1202014000 12B Apricot, juice 0.028500 1.000 0.025 1202014001 12B Apricot, juice

- babyfood 0.028500 1.000 0.025

1202230000 12B Nectarine 0.028500 1.000 0.010

1202260000 12B Peach 0.028500 1.000 0.025

1202260001 12B Peach

- babyfood 0.028500 1.000 0.025
1202261000 12B Peach, dried 0.028500 1.000 0.025
1202261001 12B Peach, dried

- babyfood 0.028500 1.000 0.025 1202262000 12B Peach, juice 0.028500 1.000 0.025

1202262001 12B Peach, juice

- babyfood 0.028500 1.000 0.025

1203285000 12C Plum 0.028500 1.000 0.025

1203285001 12C Plum

- babyfood 0.028500 1.000 0.025 1203286000 12C Plum, prune, fresh 0.028500 1.000 0.025 1203286001 12C Plum, prune, fresh

- babyfood 0.028500 1.000 0.025 1203287000 12C Plum, prune, dried 0.028500 1.000 0.025 1203287001 12C Plum, prune, dried

- babyfood 0.028500 1.00 0 0.025 1203288000 12C Plum, prune, juice 0.028500 1.000 0.025 1203288001 12C Plum, prune, juice

- babyfood 0.028500 1.000 0.025 1304175000 13D Grape 0.009500 1.000 0.025

1304176000 13D Grape, juice 0.009500 1.000 0.025 1304176001 13D Grape, juice

- babyfood 0.009500 1.000 0.025 1304179000 13D Grape, wine and sherry 0.009500 1.000 0.025

1400213000 14 Macadamia nut 0.095000 1.000 1.000

1400269000 14 Pecan 0.047500 1.000 0.010
2003128000 20C Cottonseed, oil 0.018200 1.600 0.010
2003128001 20C Cottonseed, oil

- babyfood 0.018200 1. 600 0.010
3100044000 31 Beef, meat 0.025000 1.000 1.000
3100044001 31 Beef, meat

- babyfood 0.025000 1.000 1.000
3100045000 31 Beef, meat, dried 0.025000 1.920 1.000

3100046000 3 1 Beef, meat byproducts 0.025000 1.000 1.000 3100046001 31 Beef, meat byproducts

- babyfood 0.025000 1.000 1.000
3100047000 31 Beef, fat 0.025000 1.000 1.000
3100047001 31 Beef, fat

- babyfood 0.025000 1.000 1.000 3100048000 31 Beef, kidney 0.025000 1.000 1.000
3100049000 31 Beef, liver 0.025000 1.000 1.000
3100049001 31 Beef, liver

- babyfood 0.025000 1.000 1.000
3200169000 32 Goat, meat 0.025000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.025000 1.000 1.000
3200171000 32 Goat, fat 0.025000 1.000 1.000

3200172000 32 Goat, kidney 0.025000 1.000 1.000
3200173000 32 Goat, liver 0.025000 1.000 1.000
3300189000 33 Horse, meat 0.025000 1.000 1.000
3400290000 34 Pork, meat 0.025000 1.000 1.000
3400290001 34 Pork, meat

- babyfood 0.025000 1.000 1.000
3400291000 34 Pork, skin 0.025000 1.000 1.000 3400292000 34 Pork, meat byproducts 0.025000 1.000 1.000 3400292001 34 Pork, meat byproducts

- babyfood 0.025000 1.000 1.000
3400293000 34 Pork, fat 0.025000 1.000 1.000
3400293001 34 Pork, fat

- babyfood 0.025000 1.000 1.000 3400294000 34 Pork, kidney 0.025000 1.000 1.000Fluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 18 of 21 3400295000 34 Pork, liver 0.025000 1.000 1.000 3500339000 35 Sheep, meat 0.025000 1.000 1.000 3500339001 35 Sheep, meat

- babyfood 0.025000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.025000 1.000 1.000 3500341000 35 Sheep, fat 0.025000 1.000 1.000 3500341001 35 Sheep, fat

- babyfood 0.025000 1.000 1.000 3500342000 35 Sheep, kidney 0.025000 1.000 1.000 3500343000 35 Sheep, liver 0.025000 1.000 1.000
3600222000 36 Milk, f at 0.025000 1.000 1.000
3600222001 36 Milk, fat

- baby food/infant formu 0.025000 1.000 1.000
3600223000 36 Milk, nonfat solids 0.025000 1.000 1.000
3600223001 36 Milk, nonfat solids

- baby food/in 0.025000 1.000 1.000
3600224000 36 Milk, water 0.025000 1.000 1.000
3600224001 36 Milk, water

- babyfood/infant form 0.025000 1.000 1.000
3600225001 36 Milk, sugar (lactose)

- baby food/ 0.025000 1.000 1.00 0
4000093000 40 Chicken, meat 0.025000 1.000 1.000
4000093001 40 Chicken, meat

- babyfood 0.025000 1.000 1.000
4000094000 40 Chicken, liver 0.025000 1.000 1.000

4000095000 40 Chick en, meat byproducts 0.025000 1.000 1.000 4000095001 40 Chicken, meat byproducts

- babyfoo 0.025000 1.000 1.000
4000096000 40 Chicken, fat 0.025000 1.000 1.000
4000096001 40 Chicken, fat

- babyfood 0.025000 1.000 1.000
4000097000 40 Chicken, skin 0.025000 1.000 1.000
4000097001 40 Chicken, skin

- babyfood 0.025000 1.000 1.000 5000382000 50 Turkey, meat 0.025000 1.000 1.000 5000382001 50 Turkey, meat

- babyfood 0.025000 1.000 1.000 5000383000 50 Turkey, liver 0.025000 1.000 1.000 5000383001 50 Turkey, liver

- babyfood 0.025000 1.000 1.000

5000384000 50 T urkey, meat byproducts 0.025000 1.000 1.000 5000384001 50 Turkey, meat byproducts

- babyfood 0.025000 1.000 1.000 5000385000 50 Turkey, fat 0.025000 1.000 1.000 5000385001 50 Turkey, fat

- babyfood 0.025000 1.000 1.000 5000386000 50 Turkey, skin 0.025000 1.000 1.000 5000386001 50 Turkey, skin

- babyfood 0.025000 1.000 1.000 6000301000 60 Poultry, other, meat 0.025000 1.000 1.000 6000302000 60 Poultry, other, liver 0.025000 1.000 1.000 6000303000 60 Poultry, other, meat byproducts 0.025000 1.000 1.000 6000304000 60 Poultry, other, fat 0.025000 1.000 1.000

6000305000 60 Poultry, other, skin 0.025000 1.000 1.000 7000145000 70 Egg, whole 0.025000 1.000 1.000 7000145001 70 Egg, whole

- babyfood 0.025000 1.000 1.000 7000146000 70 Egg, white 0.025000 1.000 1.000 7000146001 70 Egg, white (solids)

- babyfood 0.025000 1.000 1.000 7000147000 70 Egg, yolk 0.025000 1.000 1.000 7000147001 70 Egg, yolk

- babyfood 0.025000 1.0 00 1.000
8601000000 86A Water, direct, all sources 0.006600 1.000 1.000
8602000000 86B Water, indirect, all sources 0.006600 1.000 1.000 9500019000 O Asparagus 0.638000 1.000 0.025

9500023000 O Banana 0.009500 1.000 1.000

9500023001 O Banana

- babyfood 0.009500 1.000 1.000
9500024000 O Banana, dried 0.009500 3.900 1.000
9500024001 O Banana, dried

- babyfood 0.009500 3.900 1.000
9500115000 O Coffee, roasted bean 0.095000 1.000 1.000
9500116000 O Coffee, instant 0.095000 1.000 1.000 9500177000 O Grape, leaves 0.009500 1.000 0.025 9500178000 O Grape, raisin 0.009500 1.000 0.025

9500263000 O Peanut 0.760000 1.000 0.010
9500264000 O Peanut, butter 0.760000 1.890 0.010

9500265000 O Peanut, oil 0.760000 1.000 0.010

9500283000 O Plantain 0.009500 1.000 1.000
9500284000 O Plantain, dried 0.009500 3.900 1.000Fluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 19 of 21 

### Attachment : Chronic Results Fil e (Food + Water)

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for FLUAZIFOP

- P

- BUTYL NHANES 2003

- 2008 2

- day

Residue file name: C: \ Users \ wdonovan \ Documents \ DEEM Version 3.16 \ 122809c 2015.r08 Adjustment factor #2 used. Analysis Date 03

- 30

- 2015/12:11:31 Residue file dated: 03

- 30

- 2015/12:09:19 Reference dose (RfD, Chronic) = .0074 mg/kg bw/day

COMMENT 1: 2015 SLUA

================= ============================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

To tal Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

------------ -------------------------- ------------- ---------------- Total US Population 0.001244 16.8% Hispanic 0.001777 24.0%

Non

- Hisp

- White 0.001097 14.8%

Non

- Hisp

- Black 0.001437 19.4%

Non

- Hisp

- Other 0.001367 18.5% Nursing Infants 0.000858 11.6%

No n

- Nursing Infants 0.001898 25.6%

Female 13+ PREG 0.001478 20.0%

Children 1

- 6 0.003892 52.6%

Children 7

- 12 0.001684 22.8%

Male 13

- 19 0.001233 16.7%

Female 13

- 19/NP 0.000979 13.2%

Male 20+ 0.000909 12 .3%
Female 20+/NP 0.000881 11.9%

Seniors 55+ 0.000919 12.4%

All Infants 0.001577 21.3%

Female 13

- 50 0.000904 12.2%

Children 1

- 2 0.004756 64.3%

Children 3

- 5 0.003705 50.1%

Children 6

- 12 0.001819 24.6%

Youth 13

- 19 0.001104 14.9%

Adults 20

- 49 0.000897 12.1%

Adults 50

- 99 0.000916 12.4%

Female 13

- 49 0.000893 12.1%

-------------------------------------------------------------------------------Fluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 20 of 21 

### Attachment : Chronic Results File (Food Only)

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for FLUAZIFOP

- P

- BUTYL NHANES 2003

- 2008 2

- day

Residue file name: C: \ Users \ wdonovan \ Documents \ DEEM Version 3.16 \ 122809cfood 2015.r08 Adjustment factor #2 used. Analysis Date 03

- 30

- 2015/13:02:49 Residue file dated: 03

- 30

- 2015/13:01:41 Reference dose (RfD, Chronic) = .0074 mg/kg bw/day
COMMENT 1: Food only 2015 SLUA

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

------------------- ---------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total U S Population 0.001106 14.9% Hispanic 0.001645 22.2%

Non

- Hisp

- White 0.000955 12.9%

Non

- Hisp

- Black 0.001323 17.9%

Non

- Hisp

- Other 0.001208 16.3% Nursing Infants 0.000732 9.9%

Non

- Nursing Infants 0.001438 19.4%

F emale 13+ PREG 0.001348 18.2%

Children 1

- 6 0.003715 50.2%

Children 7

- 12 0.001568 21.2%

Male 13

- 19 0.001138 15.4%

Female 13

- 19/NP 0.000872 11.8%

Male 20+ 0.000780 10.5%
Female 20+/NP 0.000736 9.9%

Seniors 55+ 0.000786 10.6%

All Infants 0.001220 16.5%

Female 13

- 50 0.000766 10.4%

Children 1

- 2 0.004556 61.6%

Children 3

- 5 0.003537 47.8%

Children 6

- 12 0.001698 23.0%

Youth 13

- 19 0.001003 13.6%

Adults 20

- 49 0.000759 10.3%

Adults 50

- 99 0.000780 10.5%

Female 13

- 49 0.000756 10.2%

---------------------- ---------------------------------------------------------Fluazifop

- P

- butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 21 of 21 

### Attachment : BEAD SLUA

Date: March 13, 2015

Screening Level Estimates of Agricultural Uses of Fluazifop (122809)

Sorted Alphabetically Reporting Years: 2004

- 2013

Annual Average Percent Crop Tre ated

Crop Lbs. A. I

. Average Maxim u m

1 Alfalfa 1 ,000 <l <2

. 5

2 Almonds <500 < 1 <2.5

3 Apples <

. 500 < 1 <2.5

4 Apricots <5 00 <2. 5 < 2

. 5

5 Asparagus <500 <2. 5 <2.5

6 Blueberries <500 5 5

7 Cabbage <500 <2. 5 <2.5

8 Carrots 4,000 1 5 45

9 Cherries < 500 < 1 <2

. 5

10 Corn <500 <1 <2

. 5

11 Cotton 3

, 000 <1 <2

. 5

12 Dry Beans/Peas <500 <1 <2. 5

1 3 Garlic 1

, 000 10 25

1 4 Grapefruit 5 ,000 1 5 1

5

1 5 Grapes 3, 000 < 2

. 5 <2. 5

1 6 Necta rines <500 < 1 <2. 5

1 7 Onions 4,000 10 25

1 8 Oranges 1

, 000 <2

. 5 < 2

. 5

1 9 Pasture 2, 000 < 1 < 2

. 5

20 Peaches 1

, 000 <2

. 5 1 0

21 Peanuts 1

, 000 <l <2. 5

22 Pecans <500 < 1 <2. 5

23 Peppers <500 <2.5 < 2

. 5

24 Pistachios <500 <l < 2

. 5

25 Plums/Prunes <500 <2

. 5 <2

. 5

26 Potatoes <500 <l <2.5

27 Pumpkins <500 <2.5 5

28 Soybeans 1 00,000 <2. 5 5

2 9 Strawberries <500 <l <2.5

3 0 Sugar Beets <500 < 1 <2.5

3 1 Walnuts <500 <l < 2

. 5