Dinotefuran Dietary Exposure and Risk Assessment DP Number: 391889

PC Code: 044312

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY AND

 POLLUTION PREVENTION

MEMORANDUM

DATE: July 17, 2012 

SUBJECT: Dinotefuran: Acute and Chronic Aggregate (Food and Drinking Water) 

Dietary Exposure and Risk Assessments for a Section 3 Registration 

Action on Tuberous and Corm Vegetables Subgroup 1C, Onion Subgroup 

3-07A, Onion Subgroup 3-07B, Small Fruit Subgroup 13-07F, Berry 

Subgroup 13-07H, Peach, Watercress, and Tea (Import).

PC Code: 044312 DP Barcode: 391889

Decision No.: 448130 Registration No.: 86203-12 & -23, 59639-135

Petition Nos.: 1E7863 Regulatory Action: Section 3

Risk Assessment Type: Single Chemical Case No.: NA

TXR No.: NA CAS No.: 165252-70-0

MRID No.: NA 40 CFR: §180.603

REVIEWER: Cassi L. Walls, Ph.D., Senior Biologist

Risk Assessment Branch III/Health Effects Division (HED; 7509P)

THROUGH: Amelia Acierto, Biologist

Julie VanAlstine, Environmental Health Scientist

Dietary Exposure Science Advisory Council (DESAC)/HED (7509P)

TO: Barry O’Keefe, Risk Assessor

Risk Assessment Branch III/HED (7509P)

and

Sidney Jackson/Barbara Madden, RM 05

RIMUER Branch

Health Effects Division (7505P)

Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure and risk 

assessments were conducted for the insecticide, dinotefuran, using the Dietary Exposure 

Evaluation Model DEEM-FCIDTM, Version 2.03 which uses food consumption data from 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: 391889

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the U.S. Department of Agriculture’s (USDA’s) Continuing Surveys of Food Intakes by 

Individuals (CSFII) from 1994-1996 and 1998. Dietary risk assessments were performed 

to support a Section 3 registration application submitted by Interregional Research 

Project Number 4 (IR-4) for three water-dispersible granule formulations 

(DINOTEFURAN 20SG, EPA Reg. No. 86203-12; STARKLE 70SG, EPA Reg. No. 

86203-12; DINOTEFURAN 70SG, EPA Reg. No. 59639-135) to control sucking and 

chewing insects infesting berry, small fruit, bulb and green onions, peach and nectarine, 

tuberous and corm vegetables, and watercress. Additionally, IR-4 requested an import 

tolerance on tea leaves.

The most recent acute and chronic aggregate dietary assessments were conducted for 

dinotefuran in May 2011 (D388993, Barry O’Keefe, 31-MAY-2011). 

Acute Dietary Exposure Results and Characterization.

An unrefined acute screening-level dietary assessment was conducted assuming that 

100% of crops with the requested uses and currently registered uses of dinotefuran are 

treated and that all treated crops contain residues at tolerance levels. In addition, default

processing factors were assumed for both registered and requested crop uses. Potential 

residues in drinking water were included in the analyses based on surface water results 

from the screening-level FQPA Index Reservoir Screening Tool (FIRST) model as these

values were higher than the groundwater estimates from the Screening Concentration in 

Ground Water (SCIGROW) model (D394848, Ronald Parker, 12-DEC-2011). Thus, the 

results obtained from the present analyses may be considered highly conservative. At the 

95th percentile of exposure, no population subgroups exceed HED’s level of concern: the 

U.S. population occupied 2.2% of the acute population-adjusted dose (aPAD), while the 

most highly exposed population subgroup, Children 1-2 years old, occupied 5.8% of the 

aPAD. 

Chronic Dietary Exposure Results and Characterization

An unrefined chronic screening-level dietary assessment was conducted assuming that 

100% of crops with the requested uses and currently registered uses of dinotefuran are 

treated and that all treated crops contain residues at tolerance levels. In addition, default 

processing factors were assumed for both registered and requested crop uses. Potential 

residues in drinking water were included in the analyses based on surface water results 

from the screening-level FIRST model as these values were higher than the groundwater 

estimates from the SCIGROW model (D394848, Ronald Parker, 12-DEC-2011). No 

population subgroups exceed HED’s level of concern: the U.S. population occupied <1% 

of the chronic population-adjusted dose (cPAD), while the most highly exposed 

population subgroup, Children 1-2 years old, occupied 2.6% of the cPAD. 

Cancer Dietary Exposure Results and Characterization

A determination of cancer risk was not performed with DEEM-FCIDTM as part of the 

present assessment, since this chemical was classified as “Not likely to be Carcinogenic 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: 391889

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to Humans” based on negative genotoxicity and carcinogenicity in long term cancer 

studies in rats and mice.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For 

acute and chronic assessments, the risk is expressed as a percentage of a maximum 

acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable 

adverse health effects). This dose is referred to as the population-adjusted dose (PAD). 

The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by 

the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary 

risk exceeds 100% of the PAD. References which discuss the acute and chronic risk 

assessments in more detail are available on the EPA/pesticides web site: “Available 

Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, 

web link: http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see 

SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for dinotefuran was conducted to support a 

FIFRA §18 emergency exemption on pome and stone fruit (O’Keefe, D388993, 31-

MAY-2011). 

II. Residue Information

Dinotefuran [(RS)-1-methyl-2-nitro-3-(tetrahydro-3-furylmethyl)guanidine] is a Group 

4A insecticide for which permanent tolerances have been established under 40 

CFR§180.603(a) for the combined residues of dinotefuran and its metabolites DN [1-

methyl-3-(tetrahydro-3-furylmethyl)guanidine], and UF [1-methyl-3-(tetrahydro-3-

furylmethyl)-urea)]. The tolerance levels established for the following commodities 

range from 0.05 ppm to 15.0 ppm: Brassica (subgroup 5A and 5B), cotton, grape, 

grape/raisin, potato, potato chips, potato granules/flakes, tomato paste, turnip greens, 

fruiting vegetables, cucurbits, and leafy vegetables. Tolerances have also been 

established under 180,603(b) at 0.05 ppm for the fat, meat, and meat by products of 

cattle, goats, hogs, horses, sheep, and milk. In addition, a FIFRA §18 emergency 

exemption tolerance currently exists for rice, grain at 2.8 ppm.

The nature of the residue in plants and livestock commodities is understood (MARC 

report, TXR #52304, DP293759, L. Cheng, 1/20/2004). In plants, parent dinotefuran and 

the metabolites DN and UF are the residues of concern for tolerance monitoring, and 

dinotefuran, DN, UF, and PHP are the residues of concern for risk assessment. In 

livestock, dinotefuran is the residue of concern for tolerance monitoring, and dinotefuran 

and metabolites UF and FNG in ruminants, and dinotefuran and the metabolite FNG in 

poultry for risk assessment. Adequate enforcement methods exist for the determination 

of residues of concern of dinotefuran and its metabolites in/on plant commodities and in 

livestock commodities.
Dinotefuran Dietary Exposure and Risk Assessment DP Number: 391889

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For both the acute and chronic dietary analyses, the existing and recommended tolerances

were used for each food commodity residue level. Default processing factors, where 

were also used. The acute and chronic assessments also assume that 100% of the crops 

are treated. Table 1 summarizes the dinotefuran residue levels for the proposed and 

currently registered crops used in the acute and chronic dietary assessments. 

Table 1. Summary of Dinotefuran Residue Levels For Proposed and Established Tolerances Used 

in Acute and Chronic Analyses.

Commodity Tolerance Level

[Acute and Chronic] (ppm)

Berry, low growing, except strawberry, subgroup 13-

07H3

0.2

Brassica, head and stem, subgroup 5A 1 1.4

Brassica, leafy greens, subgroup 5B 1 15.0

Cattle, goat, hog, horse, and sheep 1

 Fat, meat, and meat byproducts

Milk

0.05

Cotton, undelinted seed 1 0.4

Fruit, pome2 1.0

Fruit, small, vine climbing, except fuzzy kiwifruit, 

subgroup 13-07F3

0.9

Fruit, stone2 1.0

Grape, raisin1 2.5

Onion, bulb, subgroup 3-07A3 0.15

Onion, green, subgroup 3-07B3 5.0

Peach3 1.0

Potato, chips1 0.1

Potato, granules/flakes1 0.15

Rice, grain 2 2.8

Tea, dried3 50

Tomato, paste1 1.0

Turnip greens1 15.0

Vegetable, fruiting, group 81 0.7

Vegetable, cucurbit, group 91 0.5

Vegetable, leafy, except Brassica, group 41 5.0

Vegetable, tuberous and corm, subgroup 1C3 0.05

Watercress3 8.0

1 Current Section 3 tolerance

2 Current Section 18 tolerance

3 Proposed tolerance

III. Drinking Water Data

There are no drinking water monitoring data available on the concentrations of parent 

dinotefuran, or any of its degradates. EFED provided a tier 1 dinotefuran drinking water 

assessment with estimated drinking water concentrations (EDWCs) for dinotefuran and 

its metabolites/degradates (MNG, DN, UF, DN-2-OH, and DN-3-OH) (D394848, Ronald 

Parker, 12-DEC-2011). The EDWCs for the metabolites/degradates were reported in 

parent dinotefuran equivalents. The degradates UF and DN-2-OH are photolysates and 

are not likely to be formed in the fields of most crops. The formation of these degradates 

would be a result of direct exposure of parent dinotefuran to surface waters through spray 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: 391889

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drift, or through direct application to water, followed by photolysis. The estimated values 

for DN, UF, and DN-2-OH+DN-3-OH photolysates are considered to be the upper bound 

estimates, since these degradates are likely to form only in puddles or small water 

pockets in the field through photolysis, and therefore, these EDWCs should be considered 

an unrefined assessment. The surface water EDWCs were derived using the FIRST 

simulation model. The SCIGROW model was used to derive the ground water EDWCs.

Since all EDWC values for the proposed crops are less than the previous EDWC values 

for pome and stone fruits (D389034) (Table 2), the pome and stone fruit EDWCs are still 

recommended for assessing dinotefuran residues in drinking water. Total EDWCs for 

dinotefuran residues in surface source drinking water are not expected to exceed 91.31 

μg/L for the 1 in 10 year daily peak concentration and 25.16 for the 1 in 10 year annual 

average concentration. In ground water, the EDWC for dinotefuran residues is not 

expected to exceed 3.5 μg/L. Because the surface water estimates are higher than the 

groundwater estimates, the surface water values, expressed to two significant figures and 

converted to ppm, were directly incorporated in the DEEM-FCID into the food categories 

“water, direct, all sources” and “water, indirect, all sources.” 

Table 2. Estimated Drinking Water Concentrations for Dinotefuran Total Residues (Parent + 

Degradates) for Use on Tuberous and Corm Vegetables (Crop Subgroup 1C), Berry and Small Fruits 

(Crop Subgroup 13-07F), and on Pome and Stone Fruits.

Crop (Scenario) Percent 

Cropped 

Area 

(PCA)

Acute (peak) 

Surface Water 

Concentration 

(μg/L)

Annual Average 

Surface Water 

Concentration 

(μg/L)

Ground Water 

Concentration

(μg/L)

Tuberous and Corm 

Vegetables Crop Subgroup 

(1C); Berry and Small Fruit

Crop Subgroup (13-07F). (1 

aerial appl @ 0.338 lbs 

ai/A) Parent Only

100%1 33.4 5.5 1.07

Degradates

MNG 100%1

2.67 1.12 0.33

DN 100%1

5.38 2.28 0.07

UF 100%1

2.82 1.42 0.12

DN-2-OH2 100%1

8.23 4.09 0.37

Parent + All Degradates

Tuberous and Corm 

Vegetables crop subgroup 

(1C); Berry and Small Fruit

crop subgroup (13-07F). 

(Assuming All Peaks Occur 

Simultaneously)

100%1 52.51 14.42 1.97

Document 044312 D389034 Dinotefuran Section 18 Drinking Water , May 26, 2011

Parent + All Degradates

(Pome & Stone Fruits) (2 100%1 91.31 25.16 3.5
Dinotefuran Dietary Exposure and Risk Assessment DP Number: 391889

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aerial appl @ 0.304 lbs 

ai/A) (Assuming All Peaks 

Occur Simultaneously)

1 http://www.epa.gov/oppefed1/models/water/pca_adjustment_dwa.html

2 DN-2-OH represents DN-2-OH+DN-3-OH. These two were reported as one metabolite in MRID 

45640105.

IV. DEEM-FCIDTM Program and Consumption Information

Dinotefuran acute and chronic dietary exposure assessments were conducted using the 

DEEM-FCIDTM version 2.03 modeling software. It uses food consumption data from the 

U.S. Department of Agriculture (USDA) CSFII 1994-1996 and 1998 food intake surveys. 

The 1994-96, 98 data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) 

are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or 

N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe 

translation files developed jointly by USDA/ARS and EPA. For chronic exposure 

assessment, consumption data are averaged for the entire US population and within 

population subgroups. Based on analysis of the 1994-96, 98 CSFII consumption data, 

which took into account dietary patterns of survey respondents, HED concluded that it is 

most appropriate to report risk for the following population subgroups: the general U.S. 

population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-

19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessments, an estimate of the residue level in each food or 

food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied 

by the average daily consumption estimate for that food/food form to produce a residue 

intake estimate. The resulting residue intake estimate for each food/food form is summed 

with the residue intake estimates for all other food/food forms on the commodity residue 

list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg 

body weight/day and as a percent of the cRfD. This procedure is performed for each 

population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on 

an individual-by-individual basis. The reported consumption amounts of each food item 

can be multiplied by a residue point estimate and summed to obtain a total daily pesticide 

exposure for a deterministic exposure assessment, or “matched” in multiple random 

pairings with residue values and then summed in a probabilistic assessment. The 

resulting distribution of exposures is expressed as a percentage of the aPAD on both a 

user (i.e., only those who reported eating relevant commodities/food forms) and a percapita (i.e., those who reported eating the relevant commodities as well as those who did 

not) basis. In accordance with HED policy, per capita exposure and risk are reported for 

all tiers of analysis. 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: 391889

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V. Toxicological Information

All information specific to the toxicity characteristics of dinotefuran is presented in the 

current risk assessment supporting the proposed tolerances (Barry O’Keefe et. al., July2012). For the acute and chronic exposure scenarios, the standard 100 fold UF was 

applied to account for inter-species extrapolation and intra-species variation. 

As previously noted, a cancer risk evaluation is not included in this assessment. To 

provide an overview of the toxicological profile, a summary of the doses and endpoints

selected for the relevant dietary exposure scenarios is provided in Table 3. 

Table 3. Summary of Toxicological Doses and Endpoints for Dinotefuran for Use in Dietary

Exposure Risk Assessments.

Exposure/

Scenario

Point of 

Departure

Uncertainty/FQPA 

Safety Factors

RfD, PAD, Level 

of Concern 

Study and Toxicological 

Effects

Acute 

Dietary 

(General 

Population, 

including 

Infants and 

Children)

NOAEL=125 

mg/kg/day

UFA= 10x

UFH= 10x

FQPA SF= 1x

Acute RfD = 1.25 

mg/kg/day

aPAD =1.25 

mg/kg/day

Developmental Toxicity Study 

in Rabbits

LOAEL = 300 mg/kg/day 

based on clinical signs in does 

(prone position, tremor, 

erythema) seen following a 

single dose.

Chronic 

Dietary (All 

Populations) NOAEL=99.7

mg/kg/day

UFA= 10x

UFH= 10x

FQPA SF= 1x

Chronic RfD = 

1.0

mg/kg/day

cPAD = 1.0

mg/kg/day

Chronic/Carcinogenicity Study 

in Rats

LOAEL = 991 mg/kg/day 

based on decreased body 

weight gain in females and 

evidence of nephrotoxicity.

Cancer Classification: “Not likely to be Carcinogenic to Humans” based on the 

absence of significant tumor increases in two adequate rodent 

carcinogenicity studies.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response 

data and used to mark the beginning of extrapolation to determine risk associated with lower 

environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest 

observed adverse effect level. UF = uncertainty factor. UFA = extrapolation from animal to human 

(interspecies). UFH = potential variation in sensitivity among members of the human population 

(intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). 

RfD = reference dose. MOE = margin of exposure. LOC = level of concern.

VI. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk 

exceeds 100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure 

of the U.S. population and various population subgroups. The results reported in Table 4

are for the general US Population, all infants (<1 year old), children 1-2, children 3-5, 

children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years. 

Results of Acute and Chronic Dietary (Food and Drinking Water) Exposure Analysis

Acute dietary risk analyses were conducted with the DEEM-FCIDTM model to form a

conservative evaluation of exposure for dinotefuran. At the 95th percentile of exposure, 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: 391889

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all acute analyses yielded risk estimates well below the 100% of the aPAD threshold 

level of concern for each population subgroup. For the U.S. Population subgroup, acute 

aggregate dietary risk was calculated at 2.2% of the aPAD with an exposure level of 

0.027173 mg/kg/day. For the subgroup with the highest calculated exposure, Children 1-

2 years old, acute aggregate dietary risk occupied 5.8% of the aPAD with an exposure of 

0.072092 mg/kg/day. An overview summarizing the results of the acute dietary 

assessments with the population subgroup having the highest exposure noted in bold is 

presented in Table 4.

Chronic dietary risk analyses were conducted with the DEEM-FCIDTM model to form a

conservative evaluation of exposure for dinotefuran. All chronic analyses yielded risk 

estimates well below the 100% of the cPAD threshold level of concern for each 

population subgroup. For the U.S. Population subgroup, chronic aggregate dietary risk 

was calculated at < 1.0% of the cPAD with an exposure level of 0.008041 mg/kg/day. 

For the subgroup with the highest calculated exposure, Children 1-2 years old, chronic 

aggregate dietary risk occupied 2.6% of the cPAD with an exposure of 0.025775

mg/kg/day. An overview summarizing the results of the chronic dietary assessment with 

the population subgroup having the highest exposure noted in bold is presented in Table 

4.
Dinotefuran Dietary Exposure and Risk Assessment DP Number: 391889

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Table 4. Result of Acute and Chronic Dietary Exposure and Risk Estimates for Dinotefuran 

using DEEM-FCID (food and water).

Population Subgroup*

Acute Dietary

(95 th Percentile) Chronic Dietary

Dietary 

Exposure 

(mg/kg/day) % aPAD**

Dietary 

Exposure

(mg/kg/day) % cPAD**

General U.S. Population 0.027173 2.2 0.008041 0.8

All Infants (< 1 year old) 0.061791 4.9 0.017327 1.7

Children 1-2 years old 0.072092 5.8 0.025775 2.6

Children 3-5 years old 0.052397 4.2 0.018474 1.8

Children 6-12 years old 0.028815 2.3 0.009781 1.0

Youth 13-19 years old 0.019797 1.6 0.006209 0.6

Adults 20-49 years old 0.019742 1.6 0.006311 0.6

Adults 50+ years old 0.020109 1.6 0.006453 0.6

Females 13-49 years old 0.019914 1.6 0.006307 0.6

*The values for the highest exposed population for each type of risk assessment are bolded.

** Report %PADs to 2 significant figures.

VII. Characterization of Inputs/Outputs

The acute screening-level dietary assessment conducted with DEEM-FCIDTM for 

dinotefuran is an unrefined analysis. In addition to tolerance level residues, default 

processing factors, and 100% crop treated assumptions, it utilized conservative EDWCs 

derived through EFED modeling which are unlikely to underestimate the concentration of 

dinotefuran in drinking water. The present DEEM-FCIDTM analysis assumes that all 

drinking water will contain dinotefuran at the highest acute EDWC levels modeled by 

EFED for groundwater or surface water. For these reasons, it can be concluded that the 

DEEM-FCIDTM analysis does not underestimate risk from acute exposure to dinotefuran 

for the general U.S. population and all its subgroups.

The chronic dietary assessment conducted with DEEM-FCIDTM for dinotefuran is an 

unrefined analysis. In addition to tolerance level residues, default processing factors, and 

100% crop treated assumptions, it utilized conservative EDWCs derived through EFED 

modeling which are unlikely to underestimate the concentration of dinotefuran in 

drinking water. The present DEEM-FCIDTM analysis assumes that all drinking water will 

contain dinotefuran at the highest chronic EDWC levels modeled by EFED for 

groundwater or surface water. For these reasons, it can be concluded that the DEEMFCIDTM analysis does not underestimate risk from chronic exposure to dinotefuran for 

the general U.S. population and all its subgroups.
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VIII. Conclusions

The conservative acute screening-level dietary risk assessment conducted with DEEMFCIDTM indicates that exposures to dinotefuran are below HED’s level of concern. The 

acute dietary risk to dinotefuran is estimated to be 2.2% of the aPAD for the general U.S.

population and 5.8% of the aPAD for the most highly exposed population subgroup, 

Children 1-2 years old. Therefore, HED does not have any concerns for the proposed 

new tolerances of dinotefuran.

The conservative chronic dietary risk assessment conducted with DEEM-FCIDTM

indicates that exposures to dinotefuran are below HED’s level of concern. The chronic 

dietary risk to dinotefuran is estimated to be < 1.0% of the cPAD for the general U.S.

population and 2.6% of the cPAD for the most highly exposed population subgroup, 

Children 1-2 years old. Therefore, HED does not have any concerns for the proposed new 

tolerances of dinotefuran.

IX. List of Attachments

1. Attachment 1: Acute Dietary Exposure (food + water) Input File.

2. Attachment 2: Acute Dietary Exposure (food + water) Results File.

3. Attachment 3: Chronic Dietary Exposure (food + water) Input File.

4. Attachment 4: Chronic Dietary Exposure (food + water) Results File.
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ATTACHMENT 1

Filename: C:\Documents and Settings\cwalls\My Documents\Cassi\HED\Dinotefuran\new 

tolerance 102711\acute food+water 012712.R98

Chemical: Dinotefuran

RfD(Chronic): .38 mg/kg bw/day NOEL(Chronic): 38 mg/kg bw/day

RfD(Acute): 1.25 mg/kg bw/day NOEL(Acute): 125 mg/kg bw/day

Date created/last modified: 03-28-2012/11:59:11/8 Program ver. 2.03

Comment: Acute and Chronic Dietary (food+drinking water) Assessment 

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

01030150 1CD Arrowroot, flour 0.050000 1.000 1.000 

01030151 1CD Arrowroot, flour-babyfood 0.050000 1.000 1.000 

01030170 1CD Artichoke, Jerusalem 0.050000 1.000 1.000 

01030820 1CD Cassava 0.050000 1.000 1.000 

01030821 1CD Cassava-babyfood 0.050000 1.000 1.000 

01031390 1CD Dasheen, corm 0.050000 1.000 1.000 

01031660 1CD Ginger 0.050000 1.000 1.000 

01031661 1CD Ginger-babyfood 0.050000 1.000 1.000 

01031670 1CD Ginger, dried 0.050000 1.000 1.000 

01032960 1C Potato, chips 0.100000 1.000 1.000 

01032970 1C Potato, dry (granules/ flakes) 0.150000 1.000 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 0.150000 1.000 1.000 

01032980 1C Potato, flour 0.150000 1.000 1.000 

01032981 1C Potato, flour-babyfood 0.150000 1.000 1.000 

01032990 1C Potato, tuber, w/peel 0.050000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 0.050000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 0.050000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 0.050000 1.000 1.000 

01033660 1CD Sweet potato 0.050000 1.000 1.000 

01033661 1CD Sweet potato-babyfood 0.050000 1.000 1.000 

01033710 1CD Tanier, corm 0.050000 1.000 1.000 

01033870 1CD Turmeric 0.050000 1.000 1.000 

01034060 1CD Yam, true 0.050000 1.000 1.000 

01034070 1CD Yam bean 0.050000 1.000 1.000 

03001640 3 Garlic 0.150000 1.000 1.000 

03001650 3 Garlic, dried 0.150000 1.000 1.000 

03001651 3 Garlic, dried-babyfood 0.150000 1.000 1.000 

03001980 3 Leek 5.000000 1.000 1.000 

03002370 3 Onion, dry bulb 0.150000 1.000 1.000 

03002371 3 Onion, dry bulb-babyfood 0.150000 1.000 1.000 

03002380 3 Onion, dry bulb, dried 0.150000 9.000 1.000 

03002381 3 Onion, dry bulb, dried-babyfood 0.150000 9.000 1.000 

03002390 3 Onion, green 5.000000 1.000 1.000 

03003380 3 Shallot 0.150000 1.000 1.000 

04010050 4A Amaranth, leafy 5.000000 1.000 1.000 

04010180 4A Arugula 5.000000 1.000 1.000 

04011040 4A Chrysanthemum, garland 5.000000 1.000 1.000 

04011330 4A Cress, garden 5.000000 1.000 1.000 

04011340 4A Cress, upland 5.000000 1.000 1.000 

04011380 4A Dandelion, leaves 5.000000 1.000 1.000 

04011500 4A Endive 5.000000 1.000 1.000 

04012040 4A Lettuce, head 5.000000 1.000 1.000 

04012050 4A Lettuce, leaf 5.000000 1.000 1.000 

04012480 4A Parsley, leaves 5.000000 1.000 1.000 

04013130 4A Radicchio 5.000000 1.000 1.000 

04013550 4A Spinach 5.000000 1.000 1.000 

04013551 4A Spinach-babyfood 5.000000 1.000 1.000 

04020760 4B Cardoon 5.000000 1.000 1.000 

04020850 4B Celery 5.000000 1.000 1.000 

04020851 4B Celery-babyfood 5.000000 1.000 1.000 

04020860 4B Celery, juice 5.000000 1.000 1.000 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: 391889

PC Code: 044312

______________________________________________________________________________________

Page 12 of 20

04020870 4B Celtuce 5.000000 1.000 1.000 

04021520 4B Fennel, Florence 5.000000 1.000 1.000 

04023220 4B Rhubarb 5.000000 1.000 1.000 

04023670 4B Swiss chard 5.000000 1.000 1.000 

05010610 5A Broccoli 1.400000 1.000 1.000 

05010611 5A Broccoli-babyfood 1.400000 1.000 1.000 

05010620 5A Broccoli, Chinese 1.400000 1.000 1.000 

05010640 5A Brussels sprouts 1.400000 1.000 1.000 

05010690 5A Cabbage 1.400000 1.000 1.000 

05010710 5A Cabbage, Chinese, napa 1.400000 1.000 1.000 

05010720 5A Cabbage, Chinese, mustard 1.400000 1.000 1.000 

05010830 5A Cauliflower 1.400000 1.000 1.000 

05011960 5A Kohlrabi 1.400000 1.000 1.000 

05020630 5B Broccoli raab 15.000000 1.000 1.000 

05020700 5B Cabbage, Chinese, bok choy 15.000000 1.000 1.000 

05021170 5B Collards 15.000000 1.000 1.000 

05021940 5B Kale 15.000000 1.000 1.000 

05022290 5B Mustard greens 15.000000 1.000 1.000 

05023180 5B Rape greens 15.000000 1.000 1.000 

05023890 5B Turnip, greens 15.000000 1.000 1.000 

08001480 8 Eggplant 0.700000 1.000 1.000 

08002700 8 Pepper, bell 0.700000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 0.700000 1.000 1.000 

08002710 8 Pepper, bell, dried 0.700000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 0.700000 1.000 1.000 

08002720 8 Pepper, nonbell 0.700000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 0.700000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 0.700000 1.000 1.000 

08003740 8 Tomatillo 0.700000 1.000 1.000 

08003750 8 Tomato 0.700000 1.000 1.000 

08003751 8 Tomato-babyfood 0.700000 1.000 1.000 

08003760 8 Tomato, paste 1.000000 1.000 1.000 

08003761 8 Tomato, paste-babyfood 1.000000 1.000 1.000 

08003770 8 Tomato, puree 0.700000 3.300 1.000 

08003771 8 Tomato, puree-babyfood 0.700000 3.300 1.000 

08003780 8 Tomato, dried 0.700000 14.300 1.000 

08003781 8 Tomato, dried-babyfood 0.700000 14.300 1.000 

08003790 8 Tomato, juice 0.700000 1.500 1.000 

09010750 9A Cantaloupe 0.500000 1.000 1.000 

09010800 9A Casaba 0.500000 1.000 1.000 

09011870 9A Honeydew melon 0.500000 1.000 1.000 

09013990 9A Watermelon 0.500000 1.000 1.000 

09014000 9A Watermelon, juice 0.500000 1.000 1.000 

09020210 9B Balsam pear 0.500000 1.000 1.000 

09020880 9B Chayote, fruit 0.500000 1.000 1.000 

09021020 9B Chinese waxgourd 0.500000 1.000 1.000 

09021350 9B Cucumber 0.500000 1.000 1.000 

09023080 9B Pumpkin 0.500000 1.000 1.000 

09023090 9B Pumpkin, seed 0.500000 1.000 1.000 

09023560 9B Squash, summer 0.500000 1.000 1.000 

09023561 9B Squash, summer-babyfood 0.500000 1.000 1.000 

09023570 9B Squash, winter 0.500000 1.000 1.000 

09023571 9B Squash, winter-babyfood 0.500000 1.000 1.000 

11000070 11 Apple, fruit with peel 1.000000 1.000 1.000 

11000080 11 Apple, peeled fruit 1.000000 1.000 1.000 

11000081 11 Apple, peeled fruit-babyfood 1.000000 1.000 1.000 

11000090 11 Apple, dried 1.000000 8.000 1.000 

11000091 11 Apple, dried-babyfood 1.000000 8.000 1.000 

11000100 11 Apple, juice 1.000000 1.300 1.000 

11000101 11 Apple, juice-babyfood 1.000000 1.300 1.000 

11000110 11 Apple, sauce 1.000000 1.000 1.000 

11000111 11 Apple, sauce-babyfood 1.000000 1.000 1.000 

11001290 11 Crabapple 1.000000 1.000 1.000 

11002100 11 Loquat 1.000000 1.000 1.000 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: 391889

PC Code: 044312

______________________________________________________________________________________

Page 13 of 20

11002660 11 Pear 1.000000 1.000 1.000 

11002661 11 Pear-babyfood 1.000000 1.000 1.000 

11002670 11 Pear, dried 1.000000 6.250 1.000 

11002680 11 Pear, juice 1.000000 1.000 1.000 

11002681 11 Pear, juice-babyfood 1.000000 1.000 1.000 

11003100 11 Quince 1.000000 1.000 1.000 

12000120 12 Apricot 1.000000 1.000 1.000 

12000121 12 Apricot-babyfood 1.000000 1.000 1.000 

12000130 12 Apricot, dried 1.000000 6.000 1.000 

12000140 12 Apricot, juice 1.000000 1.000 1.000 

12000141 12 Apricot, juice-babyfood 1.000000 1.000 1.000 

12000900 12 Cherry 1.000000 1.000 1.000 

12000901 12 Cherry-babyfood 1.000000 1.000 1.000 

12000910 12 Cherry, juice 1.000000 1.500 1.000 

12000911 12 Cherry, juice-babyfood 1.000000 1.500 1.000 

12002300 12 Nectarine 1.000000 1.000 1.000 

12002600 12 Peach 1.000000 1.000 1.000 

12002601 12 Peach-babyfood 1.000000 1.000 1.000 

12002610 12 Peach, dried 1.000000 7.000 1.000 

12002611 12 Peach, dried-babyfood 1.000000 7.000 1.000 

12002620 12 Peach, juice 1.000000 1.000 1.000 

12002621 12 Peach, juice-babyfood 1.000000 1.000 1.000 

12002850 12 Plum 1.000000 1.000 1.000 

12002851 12 Plum-babyfood 1.000000 1.000 1.000 

12002860 12 Plum, prune, fresh 1.000000 1.000 1.000 

12002861 12 Plum, prune, fresh-babyfood 1.000000 1.000 1.000 

12002870 12 Plum, prune, dried 1.000000 5.000 1.000 

12002871 12 Plum, prune, dried-babyfood 1.000000 5.000 1.000 

12002880 12 Plum, prune, juice 1.000000 1.400 1.000 

12002881 12 Plum, prune, juice-babyfood 1.000000 1.400 1.000 

13020570 13B Blueberry 0.200000 1.000 1.000 

13020571 13B Blueberry-babyfood 0.200000 1.000 1.000 

13021740 13B Gooseberry 0.900000 1.000 1.000 

15003230 15 Rice, white 2.800000 1.000 1.000 

15003231 15 Rice, white-babyfood 2.800000 1.000 1.000 

15003240 15 Rice, brown 2.800000 1.000 1.000 

15003241 15 Rice, brown-babyfood 2.800000 1.000 1.000 

15003250 15 Rice, flour 2.800000 1.000 1.000 

15003251 15 Rice, flour-babyfood 2.800000 1.000 1.000 

15003260 15 Rice, bran 2.800000 1.000 1.000 

15003261 15 Rice, bran-babyfood 2.800000 1.000 1.000 

21000440 M Beef, meat 0.050000 1.000 1.000 

21000441 M Beef, meat-babyfood 0.050000 1.000 1.000 

21000450 M Beef, meat, dried 0.050000 1.920 1.000 

21000460 M Beef, meat byproducts 0.050000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.050000 1.000 1.000 

21000470 M Beef, fat 0.050000 1.000 1.000 

21000471 M Beef,fat-babyfood 0.050000 1.000 1.000 

21000480 M Beef, kidney 0.050000 1.000 1.000 

21000490 M Beef, liver 0.050000 1.000 1.000 

21000491 M Beef, liver-babyfood 0.050000 1.000 1.000 

23001690 M Goat, meat 0.050000 1.000 1.000 

23001700 M Goat, meat byproducts 0.050000 1.000 1.000 

23001710 M Goat, fat 0.050000 1.000 1.000 

23001720 M Goat, kidney 0.050000 1.000 1.000 

23001730 M Goat, liver 0.050000 1.000 1.000 

24001890 M Horse, meat 0.050000 1.000 1.000 

25002900 M Pork, meat 0.050000 1.000 1.000 

25002901 M Pork, meat-babyfood 0.050000 1.000 1.000 

25002910 M Pork, skin 0.050000 1.000 1.000 

25002920 M Pork, meat byproducts 0.050000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.050000 1.000 1.000 

25002930 M Pork, fat 0.050000 1.000 1.000 

25002931 M Pork, fat-babyfood 0.050000 1.000 1.000 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: 391889

PC Code: 044312

______________________________________________________________________________________

Page 14 of 20

25002940 M Pork, kidney 0.050000 1.000 1.000 

25002950 M Pork, liver 0.050000 1.000 1.000 

26003390 M Sheep, meat 0.050000 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.050000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.050000 1.000 1.000 

26003410 M Sheep, fat 0.050000 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.050000 1.000 1.000 

26003420 M Sheep, kidney 0.050000 1.000 1.000 

26003430 M Sheep, liver 0.050000 1.000 1.000 

27002220 D Milk, fat 0.050000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.050000 1.000 1.000 

27012230 D Milk, nonfat solids 0.050000 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.050000 1.000 1.000 

27022240 D Milk, water 0.050000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.050000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.000 

28002210 M Meat, game 0.050000 1.000 1.000 

29003120 M Rabbit, meat 0.050000 1.000 1.000 

86010000 O Water, direct, all sources 0.091000 1.000 1.000 

86020000 O Water, indirect, all sources 0.091000 1.000 1.000 

95001280 O Cottonseed, oil 0.400000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.400000 1.000 1.000 

95001300 O Cranberry 0.200000 1.000 1.000 

95001301 O Cranberry-babyfood 0.200000 1.000 1.000 

95001310 O Cranberry, dried 0.200000 1.000 1.000 

95001320 O Cranberry, juice 0.200000 1.100 1.000 

95001321 O Cranberry, juice-babyfood 0.200000 1.100 1.000 

95001750 O Grape 0.900000 1.000 1.000 

95001760 O Grape, juice 0.900000 1.200 1.000 

95001761 O Grape, juice-babyfood 0.900000 1.200 1.000 

95001770 O Grape, leaves 0.900000 1.000 1.000 

95001780 O Grape, raisin 2.500000 1.000 1.000 

95001790 O Grape, wine and sherry 0.900000 1.000 1.000 

95003720 O Tea, dried 50.000000 1.000 1.000 

95003980 O Watercress 8.000000 1.000 1.000 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: 391889

PC Code: 044312

______________________________________________________________________________________

Page 15 of 20

ATTACHMENT 2

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID ACUTE Analysis for DINOTEFURAN (1994-98 data)

Residue file: acute food+water 012712.R98 Adjustment factor #2 NOT used.

Analysis Date: 03-28-2012/12:05:13 Residue file dated: 03-28-2012/11:59:11/8

NOEL (Acute) = 125.000000 mg/kg body-wt/day

Daily totals for food and foodform consumption used.

Run Comment: "Acute and Chronic Dietary (food+drinking water) Assessment "

===============================================================================

Summary calculations (per capita):

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

U.S. Population:

 0.027173 2.17 4600 0.052537 4.20 2379 0.104354 8.35 1197 

All infants:

 0.061791 4.94 2022 0.107263 8.58 1165 0.224004 17.92 558 

Children 1-2 yrs:

 0.072092 5.77 1733 0.121789 9.74 1026 0.189609 15.17 659 

Children 3-5 yrs:

 0.052397 4.19 2385 0.084070 6.73 1486 0.192028 15.36 650 

Children 6-12 yrs:

 0.028815 2.31 4337 0.046091 3.69 2712 0.080245 6.42 1557 

Youth 13-19 yrs:

 0.019797 1.58 6314 0.040851 3.27 3059 0.078850 6.31 1585 

Adults 20-49 yrs:

 0.019742 1.58 6331 0.032168 2.57 3885 0.055131 4.41 2267 

Adults 50+ yrs:

 0.020109 1.61 6216 0.034655 2.77 3606 0.067325 5.39 1856 

Females 13-49 yrs:

 0.019914 1.59 6277 0.034487 2.76 3624 0.060003 4.80 2083 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: 391889

PC Code: 044312

______________________________________________________________________________________

Page 16 of 20

ATTACHMENT 3

Filename: C:\Documents and Settings\cwalls\My Documents\Cassi\HED\Dinotefuran\new 

tolerance 102711\chronic food+water 071712.R98

Chemical: Dinotefuran

RfD(Chronic): 1 mg/kg bw/day NOEL(Chronic): 99.7 mg/kg bw/day

RfD(Acute): 1.25 mg/kg bw/day NOEL(Acute): 125 mg/kg bw/day

Date created/last modified: 07-17-2012/08:48:21/8 Program ver. 2.03

Comment: Acute and Chronic Dietary (food+drinking water) Assessment 

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

01030150 1CD Arrowroot, flour 0.050000 1.000 1.000 

01030151 1CD Arrowroot, flour-babyfood 0.050000 1.000 1.000 

01030170 1CD Artichoke, Jerusalem 0.050000 1.000 1.000 

01030820 1CD Cassava 0.050000 1.000 1.000 

01030821 1CD Cassava-babyfood 0.050000 1.000 1.000 

01031390 1CD Dasheen, corm 0.050000 1.000 1.000 

01031660 1CD Ginger 0.050000 1.000 1.000 

01031661 1CD Ginger-babyfood 0.050000 1.000 1.000 

01031670 1CD Ginger, dried 0.050000 1.000 1.000 

01032960 1C Potato, chips 0.100000 1.000 1.000 

01032970 1C Potato, dry (granules/ flakes) 0.150000 1.000 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 0.150000 1.000 1.000 

01032980 1C Potato, flour 0.150000 1.000 1.000 

01032981 1C Potato, flour-babyfood 0.150000 1.000 1.000 

01032990 1C Potato, tuber, w/peel 0.050000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 0.050000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 0.050000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 0.050000 1.000 1.000 

01033660 1CD Sweet potato 0.050000 1.000 1.000 

01033661 1CD Sweet potato-babyfood 0.050000 1.000 1.000 

01033710 1CD Tanier, corm 0.050000 1.000 1.000 

01033870 1CD Turmeric 0.050000 1.000 1.000 

01034060 1CD Yam, true 0.050000 1.000 1.000 

01034070 1CD Yam bean 0.050000 1.000 1.000 

03001640 3 Garlic 0.150000 1.000 1.000 

03001650 3 Garlic, dried 0.150000 1.000 1.000 

03001651 3 Garlic, dried-babyfood 0.150000 1.000 1.000 

03001980 3 Leek 5.000000 1.000 1.000 

03002370 3 Onion, dry bulb 0.150000 1.000 1.000 

03002371 3 Onion, dry bulb-babyfood 0.150000 1.000 1.000 

03002380 3 Onion, dry bulb, dried 0.150000 9.000 1.000 

03002381 3 Onion, dry bulb, dried-babyfood 0.150000 9.000 1.000 

03002390 3 Onion, green 5.000000 1.000 1.000 

03003380 3 Shallot 0.150000 1.000 1.000 

04010050 4A Amaranth, leafy 5.000000 1.000 1.000 

04010180 4A Arugula 5.000000 1.000 1.000 

04011040 4A Chrysanthemum, garland 5.000000 1.000 1.000 

04011330 4A Cress, garden 5.000000 1.000 1.000 

04011340 4A Cress, upland 5.000000 1.000 1.000 

04011380 4A Dandelion, leaves 5.000000 1.000 1.000 

04011500 4A Endive 5.000000 1.000 1.000 

04012040 4A Lettuce, head 5.000000 1.000 1.000 

04012050 4A Lettuce, leaf 5.000000 1.000 1.000 

04012480 4A Parsley, leaves 5.000000 1.000 1.000 

04013130 4A Radicchio 5.000000 1.000 1.000 

04013550 4A Spinach 5.000000 1.000 1.000 

04013551 4A Spinach-babyfood 5.000000 1.000 1.000 

04020760 4B Cardoon 5.000000 1.000 1.000 

04020850 4B Celery 5.000000 1.000 1.000 

04020851 4B Celery-babyfood 5.000000 1.000 1.000 

04020860 4B Celery, juice 5.000000 1.000 1.000 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: 391889

PC Code: 044312

______________________________________________________________________________________

Page 17 of 20

04020870 4B Celtuce 5.000000 1.000 1.000 

04021520 4B Fennel, Florence 5.000000 1.000 1.000 

04023220 4B Rhubarb 5.000000 1.000 1.000 

04023670 4B Swiss chard 5.000000 1.000 1.000 

05010610 5A Broccoli 1.400000 1.000 1.000 

05010611 5A Broccoli-babyfood 1.400000 1.000 1.000 

05010620 5A Broccoli, Chinese 1.400000 1.000 1.000 

05010640 5A Brussels sprouts 1.400000 1.000 1.000 

05010690 5A Cabbage 1.400000 1.000 1.000 

05010710 5A Cabbage, Chinese, napa 1.400000 1.000 1.000 

05010720 5A Cabbage, Chinese, mustard 1.400000 1.000 1.000 

05010830 5A Cauliflower 1.400000 1.000 1.000 

05011960 5A Kohlrabi 1.400000 1.000 1.000 

05020630 5B Broccoli raab 15.000000 1.000 1.000 

05020700 5B Cabbage, Chinese, bok choy 15.000000 1.000 1.000 

05021170 5B Collards 15.000000 1.000 1.000 

05021940 5B Kale 15.000000 1.000 1.000 

05022290 5B Mustard greens 15.000000 1.000 1.000 

05023180 5B Rape greens 15.000000 1.000 1.000 

05023890 5B Turnip, greens 15.000000 1.000 1.000 

08001480 8 Eggplant 0.700000 1.000 1.000 

08002700 8 Pepper, bell 0.700000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 0.700000 1.000 1.000 

08002710 8 Pepper, bell, dried 0.700000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 0.700000 1.000 1.000 

08002720 8 Pepper, nonbell 0.700000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 0.700000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 0.700000 1.000 1.000 

08003740 8 Tomatillo 0.700000 1.000 1.000 

08003750 8 Tomato 0.700000 1.000 1.000 

08003751 8 Tomato-babyfood 0.700000 1.000 1.000 

08003760 8 Tomato, paste 1.000000 1.000 1.000 

08003761 8 Tomato, paste-babyfood 1.000000 1.000 1.000 

08003770 8 Tomato, puree 0.700000 3.300 1.000 

08003771 8 Tomato, puree-babyfood 0.700000 3.300 1.000 

08003780 8 Tomato, dried 0.700000 14.300 1.000 

08003781 8 Tomato, dried-babyfood 0.700000 14.300 1.000 

08003790 8 Tomato, juice 0.700000 1.500 1.000 

09010750 9A Cantaloupe 0.500000 1.000 1.000 

09010800 9A Casaba 0.500000 1.000 1.000 

09011870 9A Honeydew melon 0.500000 1.000 1.000 

09013990 9A Watermelon 0.500000 1.000 1.000 

09014000 9A Watermelon, juice 0.500000 1.000 1.000 

09020210 9B Balsam pear 0.500000 1.000 1.000 

09020880 9B Chayote, fruit 0.500000 1.000 1.000 

09021020 9B Chinese waxgourd 0.500000 1.000 1.000 

09021350 9B Cucumber 0.500000 1.000 1.000 

09023080 9B Pumpkin 0.500000 1.000 1.000 

09023090 9B Pumpkin, seed 0.500000 1.000 1.000 

09023560 9B Squash, summer 0.500000 1.000 1.000 

09023561 9B Squash, summer-babyfood 0.500000 1.000 1.000 

09023570 9B Squash, winter 0.500000 1.000 1.000 

09023571 9B Squash, winter-babyfood 0.500000 1.000 1.000 

11000070 11 Apple, fruit with peel 1.000000 1.000 1.000 

11000080 11 Apple, peeled fruit 1.000000 1.000 1.000 

11000081 11 Apple, peeled fruit-babyfood 1.000000 1.000 1.000 

11000090 11 Apple, dried 1.000000 8.000 1.000 

11000091 11 Apple, dried-babyfood 1.000000 8.000 1.000 

11000100 11 Apple, juice 1.000000 1.300 1.000 

11000101 11 Apple, juice-babyfood 1.000000 1.300 1.000 

11000110 11 Apple, sauce 1.000000 1.000 1.000 

11000111 11 Apple, sauce-babyfood 1.000000 1.000 1.000 

11001290 11 Crabapple 1.000000 1.000 1.000 

11002100 11 Loquat 1.000000 1.000 1.000 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: 391889

PC Code: 044312

______________________________________________________________________________________

Page 18 of 20

11002660 11 Pear 1.000000 1.000 1.000 

11002661 11 Pear-babyfood 1.000000 1.000 1.000 

11002670 11 Pear, dried 1.000000 6.250 1.000 

11002680 11 Pear, juice 1.000000 1.000 1.000 

11002681 11 Pear, juice-babyfood 1.000000 1.000 1.000 

11003100 11 Quince 1.000000 1.000 1.000 

12000120 12 Apricot 1.000000 1.000 1.000 

12000121 12 Apricot-babyfood 1.000000 1.000 1.000 

12000130 12 Apricot, dried 1.000000 6.000 1.000 

12000140 12 Apricot, juice 1.000000 1.000 1.000 

12000141 12 Apricot, juice-babyfood 1.000000 1.000 1.000 

12000900 12 Cherry 1.000000 1.000 1.000 

12000901 12 Cherry-babyfood 1.000000 1.000 1.000 

12000910 12 Cherry, juice 1.000000 1.500 1.000 

12000911 12 Cherry, juice-babyfood 1.000000 1.500 1.000 

12002300 12 Nectarine 1.000000 1.000 1.000 

12002600 12 Peach 1.000000 1.000 1.000 

12002601 12 Peach-babyfood 1.000000 1.000 1.000 

12002610 12 Peach, dried 1.000000 7.000 1.000 

12002611 12 Peach, dried-babyfood 1.000000 7.000 1.000 

12002620 12 Peach, juice 1.000000 1.000 1.000 

12002621 12 Peach, juice-babyfood 1.000000 1.000 1.000 

12002850 12 Plum 1.000000 1.000 1.000 

12002851 12 Plum-babyfood 1.000000 1.000 1.000 

12002860 12 Plum, prune, fresh 1.000000 1.000 1.000 

12002861 12 Plum, prune, fresh-babyfood 1.000000 1.000 1.000 

12002870 12 Plum, prune, dried 1.000000 5.000 1.000 

12002871 12 Plum, prune, dried-babyfood 1.000000 5.000 1.000 

12002880 12 Plum, prune, juice 1.000000 1.400 1.000 

12002881 12 Plum, prune, juice-babyfood 1.000000 1.400 1.000 

13020570 13B Blueberry 0.200000 1.000 1.000 

13020571 13B Blueberry-babyfood 0.200000 1.000 1.000 

13021740 13B Gooseberry 0.900000 1.000 1.000 

15003230 15 Rice, white 2.800000 1.000 1.000 

15003231 15 Rice, white-babyfood 2.800000 1.000 1.000 

15003240 15 Rice, brown 2.800000 1.000 1.000 

15003241 15 Rice, brown-babyfood 2.800000 1.000 1.000 

15003250 15 Rice, flour 2.800000 1.000 1.000 

15003251 15 Rice, flour-babyfood 2.800000 1.000 1.000 

15003260 15 Rice, bran 2.800000 1.000 1.000 

15003261 15 Rice, bran-babyfood 2.800000 1.000 1.000 

21000440 M Beef, meat 0.050000 1.000 1.000 

21000441 M Beef, meat-babyfood 0.050000 1.000 1.000 

21000450 M Beef, meat, dried 0.050000 1.920 1.000 

21000460 M Beef, meat byproducts 0.050000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.050000 1.000 1.000 

21000470 M Beef, fat 0.050000 1.000 1.000 

21000471 M Beef,fat-babyfood 0.050000 1.000 1.000 

21000480 M Beef, kidney 0.050000 1.000 1.000 

21000490 M Beef, liver 0.050000 1.000 1.000 

21000491 M Beef, liver-babyfood 0.050000 1.000 1.000 

23001690 M Goat, meat 0.050000 1.000 1.000 

23001700 M Goat, meat byproducts 0.050000 1.000 1.000 

23001710 M Goat, fat 0.050000 1.000 1.000 

23001720 M Goat, kidney 0.050000 1.000 1.000 

23001730 M Goat, liver 0.050000 1.000 1.000 

24001890 M Horse, meat 0.050000 1.000 1.000 

25002900 M Pork, meat 0.050000 1.000 1.000 

25002901 M Pork, meat-babyfood 0.050000 1.000 1.000 

25002910 M Pork, skin 0.050000 1.000 1.000 

25002920 M Pork, meat byproducts 0.050000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.050000 1.000 1.000 

25002930 M Pork, fat 0.050000 1.000 1.000 

25002931 M Pork, fat-babyfood 0.050000 1.000 1.000 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: 391889

PC Code: 044312

______________________________________________________________________________________

Page 19 of 20

25002940 M Pork, kidney 0.050000 1.000 1.000 

25002950 M Pork, liver 0.050000 1.000 1.000 

26003390 M Sheep, meat 0.050000 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.050000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.050000 1.000 1.000 

26003410 M Sheep, fat 0.050000 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.050000 1.000 1.000 

26003420 M Sheep, kidney 0.050000 1.000 1.000 

26003430 M Sheep, liver 0.050000 1.000 1.000 

27002220 D Milk, fat 0.050000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.050000 1.000 1.000 

27012230 D Milk, nonfat solids 0.050000 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.050000 1.000 1.000 

27022240 D Milk, water 0.050000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.050000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.000 

28002210 M Meat, game 0.050000 1.000 1.000 

29003120 M Rabbit, meat 0.050000 1.000 1.000 

86010000 O Water, direct, all sources 0.025000 1.000 1.000 

86020000 O Water, indirect, all sources 0.025000 1.000 1.000 

95001280 O Cottonseed, oil 0.400000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.400000 1.000 1.000 

95001300 O Cranberry 0.200000 1.000 1.000 

95001301 O Cranberry-babyfood 0.200000 1.000 1.000 

95001310 O Cranberry, dried 0.200000 1.000 1.000 

95001320 O Cranberry, juice 0.200000 1.100 1.000 

95001321 O Cranberry, juice-babyfood 0.200000 1.100 1.000 

95001750 O Grape 0.900000 1.000 1.000 

95001760 O Grape, juice 0.900000 1.200 1.000 

95001761 O Grape, juice-babyfood 0.900000 1.200 1.000 

95001770 O Grape, leaves 0.900000 1.000 1.000 

95001780 O Grape, raisin 2.500000 1.000 1.000 

95001790 O Grape, wine and sherry 0.900000 1.000 1.000 

95003720 O Tea, dried 50.000000 1.000 1.000 

95003980 O Watercress 8.000000 1.000 1.000 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: 391889

PC Code: 044312

______________________________________________________________________________________

Page 20 of 20

ATTACHMENT 4

.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for DINOTEFURAN (1994-98 data)

Residue file name: C:\Documents and Settings\cwalls\My 

Documents\Cassi\HED\Dinotefuran\new tolerance 102711\chronic food+water 

071712.R98

 Adjustment factor #2 NOT used.

Analysis Date 07-17-2012/08:57:07 Residue file dated: 07-17-2012/08:48:21/8

Reference dose (RfD, Chronic) = 1 mg/kg bw/day

COMMENT 1: Acute and Chronic Dietary (food+drinking water) Assessment

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------

U.S. Population (total) 0.008041 0.8%

U.S. Population (spring season) 0.008025 0.8%

U.S. Population (summer season) 0.008199 0.8%

U.S. Population (autumn season) 0.008032 0.8%

U.S. Population (winter season) 0.007898 0.8%

Northeast region 0.008628 0.9%

Midwest region 0.007608 0.8%

Southern region 0.007441 0.7%

Western region 0.008930 0.9%

Hispanics 0.008781 0.9%

Non-hispanic whites 0.007460 0.7%

Non-hispanic blacks 0.008796 0.9%

Non-hisp/non-white/non-black 0.013658 1.4%

All infants (< 1 year) 0.017327 1.7%

Nursing infants 0.009114 0.9%

Non-nursing infants 0.020445 2.0%

Children 1-6 yrs 0.020093 2.0%

Children 7-12 yrs 0.009096 0.9%

Females 13-19 (not preg or nursing) 0.005975 0.6%

Females 20+ (not preg or nursing) 0.006454 0.6%

Females 13-50 yrs 0.006668 0.7%

Females 13+ (preg/not nursing) 0.006849 0.7%

Females 13+ (nursing) 0.007243 0.7%

Males 13-19 yrs 0.006405 0.6%

Males 20+ yrs 0.006249 0.6%

Seniors 55+ 0.006482 0.6%

Children 1-2 yrs 0.025775 2.6%

Children 3-5 yrs 0.018474 1.8%

Children 6-12 yrs 0.009781 1.0%

Youth 13-19 yrs 0.006209 0.6%

Adults 20-49 yrs 0.006311 0.6%

Adults 50+ yrs 0.006453 0.6%

Females 13-49 yrs 0.006307 0.6%

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