UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

MEMORANDUM 

Date: 03/31/2015 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

SUBJECT: Fluazifop-P-butyl. Acute and Chronic Aggregate Dietary (Food and Drinking 

Water) Exposure and Risk Assessments for the Sweet Potato Label Amendment 

and Resulting Increase in Tolerance Level. 

PC Code: 122809 DP Barcode: D426145 

Decision No.: 489431 Registration No.: NA 

Petition No.: 4F8262 Regulatory Action: Label Amendment 

Risk Assessment Type: Dietary Case No.: NA 

TXR No.: NA CAS No.: 79241-46-6 

MRID No.: NA 40 CFR: §180.411 

FROM: 

Risk 

William 

Assessment 

H. Donovan, 

Branch 

Ph.D., 

V 

Chemist i.J.~ ~ • o~ 

Health Effects Division (HED, 7509P) 

THROUGH: Douglas Dotson, Ph.D., Chemist ~. fi;t::;μ,.; 

Mohsen Sahafeyen, Chemist 

Dietary Exposure Science Advisory Council (DESAC) 

TO: Banza Djapao, Environmental Protection Specialist 

Fungicide Herbicide Branch 

Registration Division 

Executive Summary 

Acute and chronic aggregate dietary [food and drinking water] exposure and risk assessments 

were conducted using the Dietary Exposure Evaluation Model software with the Food 

Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food 

consumption data from the U.S. Department of Agriculture's (USDA's) National Health and 

Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA). The analyses 

were conducted in support of a human-health risk assessment for the proposed label amendment 

offluazifop-P-butyl uses on sweet potato. This memorandum was reviewed by two peer 

reviewers of the DESAC, per DESAC SOP 2012.1. 

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Fluazifop-P-buty l Dietary Exposure and Risk Assessment DP Number: 0426145 

Acute Dietary Exposure Assessment 

An unrefined acute dietary (food and drinking water) exposure assessment was conducted for all 

established and proposed uses of fluazifop-P-butyl. Acute anticipated residues for all 

commodities were determined by multiplying tolerance level residues by a metabolite ratio factor 

to include metabolites identified as residues of concern for risk assessment. Maximum estimated 

drinking water concentrations (EDWCs) from the Environmental Fate and Effects Division 

(EFED) were also included. No percent crop treated (%CT) refinements were utilized (i.e., 

100% CT was assumed for all crops). Default processing factors were used where appropriate. 

At the 95th percentile of exposure, the estimated risk is < 14% of the acute population adjusted 

dose (aPAD) for females 13-49 years old, the only relevant population subgroup. A food only 

analysis demonstrated that food is the primary contributor to aggregate (food+ water) dietary 

exposure to fluazifop-P-butyl. 

Chronic Dietary Exposure Assessment 

A partially refined chronic dietary exposure analysis was performed for all established and 

proposed uses of fluazifop-P-butyl. Mean residue levels from crop field trials with a ratio 

adjustment for additional metabolites of concern, average percent crop treated estimates, and 

experimentally determined processing factors were used in these assessments (where available; 

otherwise default processing factors were used). The estimated risk is 17% of the chronic 

population adjusted dose (cPAD) for the U.S. population. The most highly exposed population 

subgroup was Children 1-2 years old, at 64% cPAD. A food only analysis demonstrated that 

food is the primary contributor to aggregate (food+ water) dietary exposme to fluazifop-P-butyl. 

Cancer Dietary Exposure Assessment 

Fluazifop-P-butyl was classified as "Not likely to be carcinogenic to humans." Therefore, no 

cancer dietary exposure assessment was required. 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety 

factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: "Available Information on Assessing 

Exposure from Pesticides, A User's Guide," 21-JUN-2000, web link: 

http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPP-2007-0780-0001; or see SOP 

99.6 (20-AUG-1999). 

The most recent dietary risk assessment for fluazifop-P-butyl was conducted by S. Tadayon (09-

AUG-2010, D379452). 

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Fluazifop-P-butyl Dietary Exposure and Risk Assessment DP Number: D426145

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II. Residue Information

Established tolerances for fluazifop-P-butyl are listed under 40 CFR 180.411. These values form 

the basis for the residue levels used in the acute analysis with the following exceptions: grape 

tolerance of 0.01 ppm was increased to 0.03 ppm for harmonization purposes; sweet potato 

tolerance of 0.05 ppm was increased to 1.5 ppm as a result of new field trial data reflecting a PHI 

reduction from 55 days to 14 days; citrus oil tolerance of 30 ppm was reduced to 0.15 ppm based 

on the results of a citrus processing study; citrus, juice tolerance of 0.06 ppm was reduced to 0.03 

ppm based on the results of a citrus processing study; and soybean, seed tolerance of 2.5 ppm 

was increased to 4.0 ppm based on the results of additional soybean trials. The residues of 

concern identified by the Metabolism Assessment Review Committee (MARC) are summarized 

in Table 1. 

Table 1. Fluazifop-P-Butyl Residues of Concern in Plants, Livestock, and Water.

Residues of Concern

Matrix For Tolerance Expression For Risk Assessment

Plants Parent and fluazifop acid (free and 

conjugated)

Parent and fluazifop acid (free and 

conjugated), 5-trifluoromethyl-2-

pyridone, and 2-(4-

hydroxyphenoxy)propionic acid 

(free and conjugated)

Livestock Parent and fluazifop acid (free and 

conjugated)

Parent and fluazifop acid (free and 

conjugated)

Water NA Parent and fluazifop acid

For plants, the residue of concern for risk assessment includes residues of 

trifluoromethylpyridone and hydroxyphenoxypropionic acid (free and conjugated), neither of 

which are measured by the analytical method (only parent and fluazifop acid (free and

conjugated) are determined by the method). In order to account for the additional residues, a 

metabolite ratio factor was estimated from the carrot (MRID No. 47681901), endive (MRID No. 

47681902), celery (MRID No. 40693102), and soybean (MRID Nos. 41994701-41994703)

metabolism studies and applied to tolerance levels (for the acute analysis) or mean residue levels 

(for the chronic analysis). Table 2 provides information on how these factors were determined. 

Table 2. Determination of Fluazifop-P-Butyl Metabolite Ratios from Metabolism Studies.

Residue

Carrot Roots Celery Stalk Endive Soybean

%TRR ppm %TRR ppm %TRR ppm %TRR ppm

Fluazifop acid & conjugates (FA) 58.7 0.078 39.6 0.032 43.4 0.766 28 3.1

5-trifluoromethyl-2-pyridone (TMP) 15.0 0.020 2.8 0.003 10.9 0.193 – --

2-(4-hydroxyphenoxy) propionic acid

& conjugates (HPPA)

-- -- 1.1 0.001 - - 25.5 2.8

Metabolite Ratio (MR)a 1.25X 1.12X 1.25X 1.90X

a

 MR = 1 + (TMP + HPPA)/FA

For the acute assessment, the most appropriate metabolite ratio was multiplied by the tolerance 

level to provide the appropriate input residue level. For the chronic assessment, the ratio was 

multiplied by the average residue level from the field trials to provide the appropriate input 
Fluazifop-P-butyl Dietary Exposure and Risk Assessment DP Number: D426145

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residue level. These values for raw agricultural commodities (RACs) and drinking water are 

summarized in Table 3. 

Table 3. Derivation of Raw Agricultural Commodity (RAC) Anticipated Residue Levels 

For Acute and Chronic Dietary Analyses of Fluazifop-P-Butyl.

RAC Metabolite Ratio 

(MR)

Acute Analysis (ppm) Chronic Analysis (ppm)

Tolerance ARA 5 FTAvg. ARC 6

Asparagus 1.12x2 3.0 3.36 0.57 0.638

Banana/plantain 1.9 x1 0.01 0.019 0.005 0.0095

Bean, dry, seed 1.9x1 50 95 5.4 10.26

Beet, sugar, roots 1.9x1 0.25 0.475 0.08 0.152

Carrot, roots 1.25x4 2.0 2.5 0.03 0.0375

Cattle, goat, hog, horse, sheep NA 0.05 0.05 0.025 0.025

Coffee, bean 1.9x1 0.10 0.19 0.05 0.095

Cotton, undelinted seed 1.9x1 1.0 1.9 0.096 0.182

Egg NA 0.05 0.05 0.025 0.025

Endive 1.25x

3 6.0 7.5 0.238 0.298

Fruit, citrus, group 10 1.9x1 0.03 0.057 0.015 0.0285

Fruit, stone, group 12 1.9x1 0.05 0.095 0.015 0.0285

Grape 1.9x1 0.03 0.057 0.005 0.0095

Goat, hog, horse, sheep NA 0.05 0.05 0.025 0.025

Macadamia nut 1.9x 0.10 0.19 0.05 0.095

Milk NA 0.05 0.05 0.025 0.025

Onion, bulb/garlic 1.25x4 0.50 0.625 0.03 0.0375

Pecan 1.9x1 0.05 0.095 0.025 0.0475

Peanut 1.9x1 1.5 2.85 0.40 0.76

Pepper, nonbell 1.12x2 1.0 1.12 0.6 0.672

Poultry NA 0.05 0.05 0.025 0.025

Potato 1.25x4 1.0 1.25 0.11 0.138

Rhubarb 1.12x2 0.5 0.56 0.19 0.213

Soybean, seed 1.9x1 4.07 7.6 1.0 1.9

Sweet potato/yam 1.25x4 1.58 1.88 0.478 0.598

Water NA NA 0.0334 NA 0.0066

1 From soybean metabolism study.

2 From celery metabolism study (stalks).

3 From endive metabolism study.

4 From carrot metabolism study (roots).

5 ARA = MR * Tolerance

6 ARC = MR * FTAvg.

7 Recommended tolerance: D415419, W. Donovan, 18-JUN-2014.

8 Recommended tolerance: MRID 48893201.

The residue chemistry database for fluazifop-P-butyl includes processing factors as determined 

in processing studies. For processed commodities showing no residue concentration in 

comparison to the residue level in the corresponding RAC, no separate tolerance was set and, for 

the purposes of this assessment, the processing factor was set to one (1). For processed 

commodities showing residue concentration in comparison to the residue level in the 
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corresponding RAC, a separate tolerance was recommended for the processed commodity. For 

the acute analysis, since tolerance level residues were used, the processing factor was set to one 

(1) since the empirical factor was already included in the setting of the tolerance level. For the 

chronic analysis, where mean residues were used, the empirical or default processing factor was 

included in the analysis. Table 4 summarizes the processing factors and the residue levels used 

for the processed commodities.

Table 4. Derivation of Processed Commodity (PC) Anticipated Residue Levels 

For Acute and Chronic Dietary Analyses of Fluazifop-P-Butyl.

PC Metabolite 

Ratio 

Processing 

Factor

Acute Analysis (ppm) Chronic Analysis (ppm)

Tolerance ARA 4 FTAvg. ARC 5

Banana/plantain - dried 1.9 x1 3.9DD 0.01 0.019 0.005 0.0095

Beef, dried NA 1.92 DD 0.05 0.05 0.025 0.025

Beet, sugar, molasses 1.9x1 14EF 3.5 6.65 0.08 0.152

Carrot, juice 1.25x3 1 2.0 2.5 0.03 0.0375

Potato, chips 1.25x3 3.3 EF 2.0 2.5 0.11 0.138

Potato, granules/flakes 1.25x3 6.4 EF 4.0 5.0 0.11 0.138

Potato, flour 1.25x3 6.46 4.06 5.0 0.116 0.138

Cotton, oil 1.9x1 1.6 EF 1.3 2.47 0.096 0.182

Citrus, juice 1.9x1 1 0.037 0.057 0.015 0.0285

Citrus, oil 1.9x1 5.0 EF 0.15

7 0.285 0.015 0.0285

Plum, prune, dried8 1.9x1 1 0.05 0.095 0.015 0.0285

Fruit, stone, juice 1.9x1 1 0.05 0.095 0.015 0.0285

Grape, raisin 1.9x1 1 0.03 0.057 0.005 0.0095

Grape, juice/wine 1.9x1 1 0.03 0.057 0.005 0.0095

Onion, bulb, dried 1.25x3 9

DD 0.50 0.625 0.03 0.0375

Peach, dried 1.9x1 1 0.05 0.095 0.015 0.0285

Peanut, butter 1.9x1 1.89 DD 1.5 2.85 0.40 0.76

Peanut, oil 1.9x1 1 1.5 2.85 0.40 0.76

Pepper, nonbell, dried 1.12x2 1 1.0 1.12 0.6 0.672

Soybean, oil7 1.9x1 2.3EF 4.0 7.6 1.0 1.9

Soybean, flour/soy milk 1.9x1 1 4.0 7.6 1.0 1.9

Chickpea, flour 1.9x1 1 50 95 5.4 10.26

1 From soybean metabolism study.

2 From celery metabolism study (stalks).

3 From carrot metabolism study (roots).

4 ARA = MR * Tolerance

5 ARC = MR * FTAvg.

6

 Translated from potato, granules/flakes.

7 D415419, W. Donovan, 18-JUN-2014.

8 Plum processing study at 10x rate showed <LOQ residues (D319907, S. Kinard, 17-AUG-2005). Thus all stone 

fruit processed commodity concentration factors were set to 1.

DD DEEM Default processing factor.

EF

 Empirical processing factor.

For some plant commodities, no quantifiable residues were found in the field trials. In those 

cases, the tolerance level was used for the acute analysis and a value of 1⁄2LOQ was used for the 
Fluazifop-P-butyl Dietary Exposure and Risk Assessment DP Number: D426145

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chronic analysis. For livestock commodities, the same approach was taken since the tolerance 

level for all livestock commodities is set at the LOQ of 0.05 ppm.

The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009, 

and 2010. Over this 3-year period, PDP analyzed 1399 samples of catfish for fluazifop-P-butyl 

residues. None of the samples contained detectable residues. As a result, residues in fish were 

not included in the assessment.

III. Percent Crop Treated Information

BEAD provided an updated Screening Level Usage Analysis (SLUA) for fluazifop-P-butyl for 

the reporting years 2004-2013 (Memo, J. Alsadek, 27-MAR-2015). BEAD did not provide 

percent crop treated information for sweet potatoes; thus, 100% CT was assumed for this 

amended use. The SLUA run of 13-MAR-2015 is included as an attachment to this memo. 

For the acute dietary analysis, 100% crop treated was assumed for all crops.

The following average percent crop treated estimates were used in the chronic dietary risk 

assessments for the following crops that are currently registered for fluazifop-P-butyl: apricots, 

2.5%; asparagus, 2.5%; carrots, 15%; cherries, 1%; cotton, 1%; dry beans/peas. 1%; garlic, 10%; 

grapefruit, 15%; grapes, 2.5%; nectarines, 1%; onions, 10%; oranges, 2.5%; peaches, 2.5%; 

peanuts, 1%; pecans, 1%; peppers, 2.5%; plums, 2.5%; potatoes, 1%, prunes, 2.5%; soybeans, 

2.5%; and sugar beets, 1%. 100% crop treated was assumed for all other registered crops not 

listed above. 

IV. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) in the following memorandum: “Revised 

Drinking Water Assessment for the Section 3 Registration of Fluazifop-p-butyl For Use on 

bananas, plantains, citrus, grapes, and sugar beets pre-bloom and post-bloom (Wm. J. 

Shaughnessy, D371093, 05/25/2010) and incorporated directly into this dietary assessment. 

Water residues were incorporated in the DEEM-FCID into the food categories “water, direct, all 

sources” and “water, indirect, all sources.” 

Estimated drinking water concentrations (EDWCs) in ground water were modeled using Tier I 

SCIGROW (version 2.3, dated July 29, 2003) and surface water EDWCs were modeled using 

Tier II PRZM (Pesticide Root Zone Model; ver. 3.12.2, May 12, 2005) and EXAMS (Exposure 

Analysis Modeling System; Ver. 2.98.04.06). The results of this analysis are presented in Table 

5. Estimated exposure concentrations represent exposure to fluazifop acid, with assumptions that 

fluazifop acid may be present in the R or S form or as a mixture of the enantiomers. 

For aerial applications the highest surface water EDWCs reported for peak, 1 in 10 year average, 

and the 30 year average as estimated by PRZM/EXAMS for all crop use scenarios were 33.4, 6.6 

ppb, and 4.4 ppb, respectively. For ground applications the highest EDWCs for peak, 1 in 10 

year average, and the 30 year average were 32.1 ppb, 5.8 ppb, and 3.1 ppb, respectively. SCI-
Fluazifop-P-butyl Dietary Exposure and Risk Assessment DP Number: D426145

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GROW estimated the concentration of fluazifop acid in shallow ground water sources to be 1.56 

ppb. 

Table 5. Summary of the highest predicted surface and ground water concentrations for 

the drinking water assessment for the use of fluazifop-p-butyl on bananas, plantains, 

citrus, grapes, and sugar beets.

Use

Estimated Drinking Water Concentration of Fluazifop-Acid (g/L)

Acute or 

Peak

1 in 10 year Average 

(Noncancer Chronic)

30 year Average (Cancer 

Chronic) 

Aerial Applications Surface Water

Bananas & Plantains 33.4 6.2 3.2

Citrus 28.5 5.4 3.7

Grapes 19.8 6.6 4.4

Sugar Beets 13.0 4.8 3.3

Ground Applications Surface Water

Bananas & Plantains 32.1 5.8 2.7

Citrus 27.3 5.1 2.8

Grapes 16.6 5.3 3.1

Sugar Beets 10.6 3.9 2.3

Ground Water

All Uses 1.56 1.56 1.56

V. DEEM-FCID Program and Consumption Information

Fluazifop-P-butyl acute and chronic dietary exposure assessments were conducted using the 

DEEM-FCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA’s 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups. However, for acute 

exposure assessment, consumption data are retained as individual consumption events. Based on 

analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns 

and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (<1 year old), children 

1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99

years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 
Fluazifop-P-butyl Dietary Exposure and Risk Assessment DP Number: D426145

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estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

For an acute exposure assessment, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministic assessments, any significant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment.

VI. Toxicological Information

On May 6, 2004, the Health Effects Division (HED) Hazard Identification Assessment Review 

Committee (HIARC) reviewed the recommendations of the toxicology reviewer for fluazifop-butyl 

and fluazifop-P-butyl with regard to the acute and chronic dietary Reference Doses (RfDs) and the 

toxicological endpoint selection. The potential for increased susceptibility of infants and children 

from exposure to fluazifop-butyl and fluazifop-P-butyl was also evaluated as required by the Food 

Quality Protection Act (FQPA) of 1996 (TXR NO. 0052611; memo dated June 15, 2004 by D. 

Anderson). The established toxicological doses and endpoints for fluazifop-P-butyl are presented in 

Table 6 below. These selections are supported by the current fluazifop-P-butyl risk assessment 

team.

Table 6. Summary of Toxicological Doses and Endpoints for Fluazifop-P-Butyl for Use in Dietary Exposure 

Assessment

Exposure

Scenario

Dose Used in Risk

Assessment, UF

Hazard and Exposure 

Based FQPA Safety 

Factor Study and Toxicological Effects

Acute Dietary

(General population 

including infants and 

children)

An appropriate endpoint attributable to a single dose was not identified in the available 

studies including the developmental toxicity studies.

Acute Dietary

(Females 13-49 years of 

age)

NOAEL = 50 

mg/kg/day

UF = 100

Acute RfD = 0.50 

mg/kg

FQPA SF = 1X

aPAD = acute RfD

 FQPA SF

= 0.50 mg/kg/day

Developmental Toxicity in rats.

LOAEL = 200 mg/kg/day based on 

diaphragmatic hernia.

Chronic Dietary

(All populations)

NOAEL= 0.74 

mg/kg/day

UF = 100

Chronic RfD = 

0.0074 mg/kg/day

FQPA SF = 1X

cPAD = chronic RfD

 FQPA SF

= 0.0074 mg/kg/day

Two-Generation Reproduction in 

rats.

LOAEL = 5.8 mg/kg/day in males 

and 7.1 in females based on 

decreased spleen, testes &
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Table 6. Summary of Toxicological Doses and Endpoints for Fluazifop-P-Butyl for Use in Dietary Exposure 

Assessment

Exposure

Scenario

Dose Used in Risk

Assessment, UF

Hazard and Exposure 

Based FQPA Safety 

Factor Study and Toxicological Effects

epididymal weights in males and 

uterine & pituitary weights in 

females.

Cancer “Not likely to be carcinogenic to humans.”

VII. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCID analyses estimate the dietary exposure and risk of the U.S. 

population and various population subgroups. The results reported in Table 7 are for the general 

U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

females 13-49, adults 20-49, and adults 50-99 years. 

Results of Acute Dietary Exposure and Risk Analysis

The food plus drinking water results of the acute dietary exposure and risk analysis at the 95th

percentile of exposure are reported in Table 7, below. The unrefined acute dietary risk estimate

is below the Agency’s level of concern (<100% aPAD) for the only relevant population 

subgroup, females 13-49 years of age (14% aPAD), at the 95th exposure percentile. The food 

only results are presented in Table 8 and demonstrate that the drinking water contribution to total 

dietary exposure is small compared to food. 

Results of Chronic Dietary Exposure and Risk Analysis

The food plus drinking water results of the chronic dietary exposure and risk analysis are 

reported in the summary table below. The analysis indicates that for all supported commodities 

and proposed uses, the chronic dietary risk estimates are below the Agency’s level of concern 

(<100% cPAD) for the U.S. population (17% cPAD) and all population subgroups. The most 

highly exposed population subgroup in the chronic dietary exposure analysis is Children 1-2 

years of age (64% cPAD). The food only results are presented in Table 8 and demonstrate that 

the drinking water contribution to total dietary exposure is small compared to the food

contribution. 
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Table 7. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Fluazifop-PButyl.

Population Subgroup

Acute Dietary

(95th Percentile) Chronic Dietary Cancer

Dietary 

Exposure 

(mg/kg/day)

% aPAD*

Dietary 

Exposure

(mg/kg/day)

% cPAD*

Dietary 

Exposure

(mg/kg/day)

Risk

General U.S. Population

NA NA

0.001244 17

NA NA

All Infants (<1 year old) 0.001577 21

Children 1-2 years old* 0.004756 64

Children 3-5 years old 0.003705 50

Children 6-12 years old 0.001819 25

Youth 13-19 years old 0.001104 15

Adults 20-49 years old 0.000897 12

Adults 50-99 years old 0.000916 12

Females 13-49 years old* 0.067665 14 0.000893 12

*The subpopulations with the highest risk estimates.

Table 8. Summary of Dietary (Food Only) Exposure and Risk for Fluazifop-P-Butyl.

Population Subgroup

Acute Dietary

(95th Percentile) Chronic Dietary Cancer

Dietary 

Exposure 

(mg/kg/day)

% aPAD*

Dietary 

Exposure

(mg/kg/day)

% cPAD*

Dietary 

Exposure

(mg/kg/day)

Risk

General U.S. Population

NA NA

0.001106 15

NA NA

All Infants (<1 year old) 0.001220 17

Children 1-2 years old* 0.004556 62

Children 3-5 years old 0.003537 48

Children 6-12 years old 0.001698 23

Youth 13-19 years old 0.001003 14

Adults 20-49 years old 0.000759 10

Adults 50-99 years old 0.000780 11

Females 13-49 years old* 0.067118 13 0.000756 10

*The subpopulations with the highest risk estimates.

VIII. Characterization of Inputs/Outputs

The acute dietary exposure and risk analyses are based on tolerance-level residues, 100% crop 

treated assumptions, and default processing factors. Various refinements could be made to the 

assessments. However, as there are no risk estimates of concern, no refinements were 

incorporated.

The chronic dietary exposure and risk analyses are based on mean field trial residues, average

percent crop treated data as provided by BEAD, and empirical processing factors. As such, these 

analyses may be considered partially refined. At this level of refinement, risk levels are below 

HED’s level of concern and thus no further refinements were needed. Should more refinements 

be needed in the future, the use of monitoring data may be considered. 
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IX. Conclusions

Unrefined acute dietary exposure analyses (deterministic) for all uses of fluazifop-P-butyl give 

risk estimates for the relevant population subgroup, females 13-49 years old, that are below 

HED’s level of concern at the 95th percentile of exposure. Partially refined chronic dietary 

exposure analyses for all uses of fluazifop-P-butyl give risk estimates for all population 

subgroups that are below HED’s level of concern. 

HED is confident that the assessment does not underestimate risk to the general U.S. population 

or any population subgroup.

X. List of Attachments

• Acute Residue Input file

• Acute Results file (Food + Water)

• Acute Results file (Food Only)

• Chronic Residue Input file

• Chronic Results File (Food + Water)

• Chronic Results file (Food Only)

• BEAD SLUA
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Attachment: Acute Food plus Water Residue Input File

Filename: C:\Users\wdonovan\Documents\DEEM Version 3.16\122809a 2015.r08

Chemical: Fluazifop-P-Butyl

RfD(Chronic): .0074 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .5 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 03-30-2015/13:11:19 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101052000 1A Beet, sugar 0.475000 1.000 1.000 

0101052001 1A Beet, sugar-babyfood 0.475000 1.000 1.000 

0101053000 1A Beet, sugar, molasses 6.650000 1.000 1.000 

0101053001 1A Beet, sugar, molasses-babyfood 6.650000 1.000 1.000 

0101078000 1AB Carrot 2.500000 1.000 1.000 

0101078001 1AB Carrot-babyfood 2.500000 1.000 1.000 

0101079000 1AB Carrot, juice 2.500000 1.000 1.000 

0103296000 1C Potato, chips 2.500000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 5.000000 1.000 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 5.000000 1.000 1.000 

0103298000 1C Potato, flour 5.000000 1.000 1.000 

0103298001 1C Potato, flour-babyfood 5.000000 1.000 1.000 

0103299000 1C Potato, tuber, w/peel 1.250000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 1.250000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 1.250000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 1.250000 1.000 1.000 

0103366000 1CD Sweet potato 1.880000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 1.880000 1.000 1.000 

0103406000 1CD Yam, true 1.880000 1.000 1.000 

0103407000 1CD Yam bean 1.880000 1.000 1.000 

0301165000 3A Garlic, bulb 0.625000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 0.625000 1.000 1.000 

0301237000 3A Onion, bulb 0.625000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.625000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.625000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.625000 9.000 1.000 

0401150000 4A Endive 7.500000 1.000 1.000 

0402322000 4B Rhubarb 0.560000 1.000 1.000 

0600347000 6 Soybean, seed 7.600000 1.000 1.000 

0600349000 6 Soybean, soy milk 7.600000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 7.600000 1.000 1.000 

0600350000 6 Soybean, oil 7.600000 2.300 1.000 

0600350001 6 Soybean, oil-babyfood 7.600000 2.300 1.000 

0603030000 6C Bean, black, seed 95.000000 1.000 1.000 

0603032000 6C Bean, broad, seed 95.000000 1.000 1.000 

0603034000 6C Bean, cowpea, seed 95.000000 1.000 1.000 

0603035000 6C Bean, great northern, seed 95.000000 1.000 1.000 

0603036000 6C Bean, kidney, seed 95.000000 1.000 1.000 

0603038000 6C Bean, lima, seed 95.000000 1.000 1.000 

0603039000 6C Bean, mung, seed 95.000000 1.000 1.000 

0603040000 6C Bean, navy, seed 95.000000 1.000 1.000 

0603041000 6C Bean, pink, seed 95.000000 1.000 1.000 

0603042000 6C Bean, pinto, seed 95.000000 1.000 1.000 

0603098000 6C Chickpea, seed 95.000000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 95.000000 1.000 1.000 

0603099000 6C Chickpea, flour 95.000000 1.000 1.000 

0603182000 6C Guar, seed 95.000000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 95.000000 1.000 1.000 

0603203000 6C Lentil, seed 95.000000 1.000 1.000 

0603348000 6C Soybean, flour 7.600000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 7.600000 1.000 1.000 

0802272000 8BC Pepper, nonbell 1.120000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 1.120000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 1.120000 1.000 1.000 

1001106000 10A Citron 0.057000 1.000 1.000 

1001107000 10A Citrus hybrids 0.057000 1.000 1.000 

1001108000 10A Citrus, oil 0.285000 1.000 1.000 

1001240000 10A Orange 0.057000 1.000 1.000 

1001241000 10A Orange, juice 0.057000 1.000 1.000 
Fluazifop-P-butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 13 of 21

1001241001 10A Orange, juice-babyfood 0.057000 1.000 1.000 

1001242000 10A Orange, peel 0.057000 1.000 1.000 

1001369000 10A Tangerine 0.057000 1.000 1.000 

1001370000 10A Tangerine, juice 0.057000 1.000 1.000 

1002197000 10B Kumquat 0.057000 1.000 1.000 

1002199000 10B Lemon 0.057000 1.000 1.000 

1002200000 10B Lemon, juice 0.057000 1.000 1.000 

1002200001 10B Lemon, juice-babyfood 0.057000 1.000 1.000 

1002201000 10B Lemon, peel 0.057000 1.000 1.000 

1002206000 10B Lime 0.057000 1.000 1.000 

1002207000 10B Lime, juice 0.057000 1.000 1.000 

1002207001 10B Lime, juice-babyfood 0.057000 1.000 1.000 

1003180000 10C Grapefruit 0.057000 1.000 1.000 

1003181000 10C Grapefruit, juice 0.057000 1.000 1.000 

1003307000 10C Pummelo 0.057000 1.000 1.000 

1201090000 12A Cherry 0.095000 1.000 1.000 

1201090001 12A Cherry-babyfood 0.095000 1.000 1.000 

1201091000 12A Cherry, juice 0.095000 1.000 1.000 

1201091001 12A Cherry, juice-babyfood 0.095000 1.000 1.000 

1202012000 12B Apricot 0.095000 1.000 1.000 

1202012001 12B Apricot-babyfood 0.095000 1.000 1.000 

1202013000 12B Apricot, dried 0.095000 1.000 1.000 

1202014000 12B Apricot, juice 0.095000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 0.095000 1.000 1.000 

1202230000 12B Nectarine 0.095000 1.000 1.000 

1202260000 12B Peach 0.095000 1.000 1.000 

1202260001 12B Peach-babyfood 0.095000 1.000 1.000 

1202261000 12B Peach, dried 0.095000 1.000 1.000 

1202261001 12B Peach, dried-babyfood 0.095000 1.000 1.000 

1202262000 12B Peach, juice 0.095000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 0.095000 1.000 1.000 

1203285000 12C Plum 0.095000 1.000 1.000 

1203285001 12C Plum-babyfood 0.095000 1.000 1.000 

1203286000 12C Plum, prune, fresh 0.095000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 0.095000 1.000 1.000 

1203287000 12C Plum, prune, dried 0.095000 1.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 0.095000 1.000 1.000 

1203288000 12C Plum, prune, juice 0.095000 1.000 1.000 

1203288001 12C Plum, prune, juice-babyfood 0.095000 1.000 1.000 

1304175000 13D Grape 0.057000 1.000 1.000 

1304176000 13D Grape, juice 0.057000 1.000 1.000 

1304176001 13D Grape, juice-babyfood 0.057000 1.000 1.000 

1304179000 13D Grape, wine and sherry 0.057000 1.000 1.000 

1400213000 14 Macadamia nut 0.190000 1.000 1.000 

1400269000 14 Pecan 0.095000 1.000 1.000 

2003128000 20C Cottonseed, oil 2.470000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 2.470000 1.000 1.000 

3100044000 31 Beef, meat 0.050000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.050000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.050000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.050000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.050000 1.000 1.000 

3100047000 31 Beef, fat 0.050000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.050000 1.000 1.000 

3100048000 31 Beef, kidney 0.050000 1.000 1.000 

3100049000 31 Beef, liver 0.050000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.050000 1.000 1.000 

3200169000 32 Goat, meat 0.050000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.050000 1.000 1.000 

3200171000 32 Goat, fat 0.050000 1.000 1.000 

3200172000 32 Goat, kidney 0.050000 1.000 1.000 

3200173000 32 Goat, liver 0.050000 1.000 1.000 

3300189000 33 Horse, meat 0.050000 1.000 1.000 

3400290000 34 Pork, meat 0.050000 1.000 1.000 

3400290001 34 Pork, meat-babyfood 0.050000 1.000 1.000 

3400291000 34 Pork, skin 0.050000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.050000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.050000 1.000 1.000 

3400293000 34 Pork, fat 0.050000 1.000 1.000 

3400293001 34 Pork, fat-babyfood 0.050000 1.000 1.000 

3400294000 34 Pork, kidney 0.050000 1.000 1.000 
Fluazifop-P-butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 14 of 21

3400295000 34 Pork, liver 0.050000 1.000 1.000 

3500339000 35 Sheep, meat 0.050000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.050000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.050000 1.000 1.000 

3500341000 35 Sheep, fat 0.050000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.050000 1.000 1.000 

3500342000 35 Sheep, kidney 0.050000 1.000 1.000 

3500343000 35 Sheep, liver 0.050000 1.000 1.000 

3600222000 36 Milk, fat 0.050000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.050000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.050000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.050000 1.000 1.000 

3600224000 36 Milk, water 0.050000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.050000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.000 

4000093000 40 Chicken, meat 0.050000 1.000 1.000 

4000093001 40 Chicken, meat-babyfood 0.050000 1.000 1.000 

4000094000 40 Chicken, liver 0.050000 1.000 1.000 

4000095000 40 Chicken, meat byproducts 0.050000 1.000 1.000 

4000095001 40 Chicken, meat byproducts-babyfoo 0.050000 1.000 1.000 

4000096000 40 Chicken, fat 0.050000 1.000 1.000 

4000096001 40 Chicken, fat-babyfood 0.050000 1.000 1.000 

4000097000 40 Chicken, skin 0.050000 1.000 1.000 

4000097001 40 Chicken, skin-babyfood 0.050000 1.000 1.000 

5000382000 50 Turkey, meat 0.050000 1.000 1.000 

5000382001 50 Turkey, meat-babyfood 0.050000 1.000 1.000 

5000383000 50 Turkey, liver 0.050000 1.000 1.000 

5000383001 50 Turkey, liver-babyfood 0.050000 1.000 1.000 

5000384000 50 Turkey, meat byproducts 0.050000 1.000 1.000 

5000384001 50 Turkey, meat byproducts-babyfood 0.050000 1.000 1.000 

5000385000 50 Turkey, fat 0.050000 1.000 1.000 

5000385001 50 Turkey, fat-babyfood 0.050000 1.000 1.000 

5000386000 50 Turkey, skin 0.050000 1.000 1.000 

5000386001 50 Turkey, skin-babyfood 0.050000 1.000 1.000 

6000301000 60 Poultry, other, meat 0.050000 1.000 1.000 

6000302000 60 Poultry, other, liver 0.050000 1.000 1.000 

6000303000 60 Poultry, other, meat byproducts 0.050000 1.000 1.000 

6000304000 60 Poultry, other, fat 0.050000 1.000 1.000 

6000305000 60 Poultry, other, skin 0.050000 1.000 1.000 

7000145000 70 Egg, whole 0.050000 1.000 1.000 

7000145001 70 Egg, whole-babyfood 0.050000 1.000 1.000 

7000146000 70 Egg, white 0.050000 1.000 1.000 

7000146001 70 Egg, white (solids)-babyfood 0.050000 1.000 1.000 

7000147000 70 Egg, yolk 0.050000 1.000 1.000 

7000147001 70 Egg, yolk-babyfood 0.050000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.033400 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.033400 1.000 1.000 

9500019000 O Asparagus 3.360000 1.000 1.000 

9500023000 O Banana 0.019000 1.000 1.000 

9500023001 O Banana-babyfood 0.019000 1.000 1.000 

9500024000 O Banana, dried 0.019000 3.900 1.000 

9500024001 O Banana, dried-babyfood 0.019000 3.900 1.000 

9500115000 O Coffee, roasted bean 0.190000 1.000 1.000 

9500116000 O Coffee, instant 0.190000 1.000 1.000 

9500177000 O Grape, leaves 0.057000 1.000 1.000 

9500178000 O Grape, raisin 0.057000 1.000 1.000 

9500263000 O Peanut 2.850000 1.000 1.000 

9500264000 O Peanut, butter 2.850000 1.890 1.000 

9500265000 O Peanut, oil 2.850000 1.000 1.000 

9500283000 O Plantain 0.019000 1.000 1.000 

9500284000 O Plantain, dried 0.019000 3.900 1.000 
Fluazifop-P-butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 15 of 21

Attachment: Acute Results File (Food + Water)

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for FLUAZIFOP-P-BUTYL NHANES 2003-2008 2-Day

Residue file: 122809a 2015.r08 Adjustment factor #2 NOT used.

Analysis Date: 03-30-2015/13:12:56 Residue file dated: 03-30-2015/13:11:19

RAC/FF intake summed over 24 hours

Run Comment: "food and water"

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Female 13-49:

 0.067665 13.53 0.134148 26.83 0.277261 55.45 

Attachment: Acute Results File (Food Only)

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for FLUAZIFOP-P-BUTYL NHANES 2003-2008 2-Day

Residue file: 122809afood 2015.r08 Adjustment factor #2 NOT used.

Analysis Date: 03-30-2015/13:17:02 Residue file dated: 03-30-2015/13:15:12

RAC/FF intake summed over 24 hours

Run Comment: "food only"

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Female 13-49:

 0.067118 13.42 0.133344 26.67 0.277179 55.44 
Fluazifop-P-butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 16 of 21

Attachment: Chronic Food plus Water Residue Input File

Filename: C:\Users\wdonovan\Documents\DEEM Version 3.16\122809c 2015.r08

Chemical: Fluazifop-P-Butyl

RfD(Chronic): .0074 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .5 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 03-30-2015/12:09:19 Program ver. 3.16, 03-08-d

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101052000 1A Beet, sugar 0.152000 1.000 0.010 

0101052001 1A Beet, sugar-babyfood 0.152000 1.000 0.010 

0101053000 1A Beet, sugar, molasses 0.152000 14.000 0.010 

0101053001 1A Beet, sugar, molasses-babyfood 0.152000 14.000 0.010 

0101078000 1AB Carrot 0.037500 1.000 0.150 

0101078001 1AB Carrot-babyfood 0.037500 1.000 0.150 

0101079000 1AB Carrot, juice 0.037500 1.000 0.150 

0103296000 1C Potato, chips 0.138000 3.300 0.010 

0103297000 1C Potato, dry (granules/ flakes) 0.138000 6.400 0.010 

0103297001 1C Potato, dry (granules/ flakes)-b 0.138000 6.400 0.010 

0103298000 1C Potato, flour 0.138000 6.400 0.010 

0103298001 1C Potato, flour-babyfood 0.138000 6.400 0.010 

0103299000 1C Potato, tuber, w/peel 0.138000 1.000 0.010 

0103299001 1C Potato, tuber, w/peel-babyfood 0.138000 1.000 0.010 

0103300000 1C Potato, tuber, w/o peel 0.138000 1.000 0.010 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.138000 1.000 0.010 

0103366000 1CD Sweet potato 0.598000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.598000 1.000 1.000 

0103406000 1CD Yam, true 0.598000 1.000 1.000 

0103407000 1CD Yam bean 0.598000 1.000 1.000 

0301165000 3A Garlic, bulb 0.037500 1.000 0.100 

0301165001 3A Garlic, bulb-babyfood 0.037500 1.000 0.100 

0301237000 3A Onion, bulb 0.037500 1.000 0.100 

0301237001 3A Onion, bulb-babyfood 0.037500 1.000 0.100 

0301238000 3A Onion, bulb, dried 0.037500 9.000 0.100 

0301238001 3A Onion, bulb, dried-babyfood 0.037500 9.000 0.100 

0401150000 4A Endive 0.298000 1.000 1.000 

0402322000 4B Rhubarb 0.213000 1.000 1.000 

0600347000 6 Soybean, seed 1.900000 1.000 0.025 

0600349000 6 Soybean, soy milk 1.900000 1.000 0.025 

0600349001 6 Soybean, soy milk-babyfood or in 1.900000 1.000 0.025 

0600350000 6 Soybean, oil 1.900000 2.300 0.025 

0600350001 6 Soybean, oil-babyfood 1.900000 2.300 0.025 

0603030000 6C Bean, black, seed 10.260000 1.000 0.010 

0603032000 6C Bean, broad, seed 10.260000 1.000 0.010 

0603034000 6C Bean, cowpea, seed 10.260000 1.000 0.010 

0603035000 6C Bean, great northern, seed 10.260000 1.000 0.010 

0603036000 6C Bean, kidney, seed 10.260000 1.000 0.010 

0603038000 6C Bean, lima, seed 10.260000 1.000 0.010 

0603039000 6C Bean, mung, seed 10.260000 1.000 0.010 

0603040000 6C Bean, navy, seed 10.260000 1.000 0.010 

0603041000 6C Bean, pink, seed 10.260000 1.000 0.010 

0603042000 6C Bean, pinto, seed 10.260000 1.000 0.010 

0603098000 6C Chickpea, seed 10.260000 1.000 0.010 

0603098001 6C Chickpea, seed-babyfood 10.260000 1.000 0.010 

0603099000 6C Chickpea, flour 10.260000 1.000 0.010 

0603182000 6C Guar, seed 10.260000 1.000 0.010 

0603182001 6C Guar, seed-babyfood 10.260000 1.000 0.010 

0603203000 6C Lentil, seed 10.260000 1.000 0.010 

0603348000 6C Soybean, flour 1.900000 1.000 0.025 

0603348001 6C Soybean, flour-babyfood 1.900000 1.000 0.025 

0802272000 8BC Pepper, nonbell 0.672000 1.000 0.025 

0802272001 8BC Pepper, nonbell-babyfood 0.672000 1.000 0.025 

0802273000 8BC Pepper, nonbell, dried 0.672000 1.000 0.025 

1001106000 10A Citron 0.028500 1.000 1.000 

1001107000 10A Citrus hybrids 0.028500 1.000 1.000 

1001108000 10A Citrus, oil 0.028500 5.000 1.000 

1001240000 10A Orange 0.028500 1.000 25.000 

1001241000 10A Orange, juice 0.028500 1.000 25.000 
Fluazifop-P-butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 17 of 21

1001241001 10A Orange, juice-babyfood 0.028500 1.000 25.000 

1001242000 10A Orange, peel 0.028500 1.000 25.000 

1001369000 10A Tangerine 0.028500 1.000 1.000 

1001370000 10A Tangerine, juice 0.028500 1.000 1.000 

1002197000 10B Kumquat 0.028500 1.000 1.000 

1002199000 10B Lemon 0.028500 1.000 1.000 

1002200000 10B Lemon, juice 0.028500 1.000 1.000 

1002200001 10B Lemon, juice-babyfood 0.028500 1.000 1.000 

1002201000 10B Lemon, peel 0.028500 1.000 1.000 

1002206000 10B Lime 0.028500 1.000 1.000 

1002207000 10B Lime, juice 0.028500 1.000 1.000 

1002207001 10B Lime, juice-babyfood 0.028500 1.000 1.000 

1003180000 10C Grapefruit 0.028500 1.000 0.150 

1003181000 10C Grapefruit, juice 0.028500 1.000 0.150 

1003307000 10C Pummelo 0.028500 1.000 1.000 

1201090000 12A Cherry 0.028500 1.000 0.010 

1201090001 12A Cherry-babyfood 0.028500 1.000 0.010 

1201091000 12A Cherry, juice 0.028500 1.000 0.010 

1201091001 12A Cherry, juice-babyfood 0.028500 1.000 0.010 

1202012000 12B Apricot 0.028500 1.000 0.025 

1202012001 12B Apricot-babyfood 0.028500 1.000 0.025 

1202013000 12B Apricot, dried 0.028500 1.000 0.025 

1202014000 12B Apricot, juice 0.028500 1.000 0.025 

1202014001 12B Apricot, juice-babyfood 0.028500 1.000 0.025 

1202230000 12B Nectarine 0.028500 1.000 0.010 

1202260000 12B Peach 0.028500 1.000 0.025 

1202260001 12B Peach-babyfood 0.028500 1.000 0.025 

1202261000 12B Peach, dried 0.028500 1.000 0.025 

1202261001 12B Peach, dried-babyfood 0.028500 1.000 0.025 

1202262000 12B Peach, juice 0.028500 1.000 0.025 

1202262001 12B Peach, juice-babyfood 0.028500 1.000 0.025 

1203285000 12C Plum 0.028500 1.000 0.025 

1203285001 12C Plum-babyfood 0.028500 1.000 0.025 

1203286000 12C Plum, prune, fresh 0.028500 1.000 0.025 

1203286001 12C Plum, prune, fresh-babyfood 0.028500 1.000 0.025 

1203287000 12C Plum, prune, dried 0.028500 1.000 0.025 

1203287001 12C Plum, prune, dried-babyfood 0.028500 1.000 0.025 

1203288000 12C Plum, prune, juice 0.028500 1.000 0.025 

1203288001 12C Plum, prune, juice-babyfood 0.028500 1.000 0.025 

1304175000 13D Grape 0.009500 1.000 0.025 

1304176000 13D Grape, juice 0.009500 1.000 0.025 

1304176001 13D Grape, juice-babyfood 0.009500 1.000 0.025 

1304179000 13D Grape, wine and sherry 0.009500 1.000 0.025 

1400213000 14 Macadamia nut 0.095000 1.000 1.000 

1400269000 14 Pecan 0.047500 1.000 0.010 

2003128000 20C Cottonseed, oil 0.018200 1.600 0.010 

2003128001 20C Cottonseed, oil-babyfood 0.018200 1.600 0.010 

3100044000 31 Beef, meat 0.025000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.025000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.025000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.025000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.025000 1.000 1.000 

3100047000 31 Beef, fat 0.025000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.025000 1.000 1.000 

3100048000 31 Beef, kidney 0.025000 1.000 1.000 

3100049000 31 Beef, liver 0.025000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.025000 1.000 1.000 

3200169000 32 Goat, meat 0.025000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.025000 1.000 1.000 

3200171000 32 Goat, fat 0.025000 1.000 1.000 

3200172000 32 Goat, kidney 0.025000 1.000 1.000 

3200173000 32 Goat, liver 0.025000 1.000 1.000 

3300189000 33 Horse, meat 0.025000 1.000 1.000 

3400290000 34 Pork, meat 0.025000 1.000 1.000 

3400290001 34 Pork, meat-babyfood 0.025000 1.000 1.000 

3400291000 34 Pork, skin 0.025000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.025000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.025000 1.000 1.000 

3400293000 34 Pork, fat 0.025000 1.000 1.000 

3400293001 34 Pork, fat-babyfood 0.025000 1.000 1.000 

3400294000 34 Pork, kidney 0.025000 1.000 1.000 
Fluazifop-P-butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 18 of 21

3400295000 34 Pork, liver 0.025000 1.000 1.000 

3500339000 35 Sheep, meat 0.025000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.025000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.025000 1.000 1.000 

3500341000 35 Sheep, fat 0.025000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.025000 1.000 1.000 

3500342000 35 Sheep, kidney 0.025000 1.000 1.000 

3500343000 35 Sheep, liver 0.025000 1.000 1.000 

3600222000 36 Milk, fat 0.025000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.025000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.025000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.025000 1.000 1.000 

3600224000 36 Milk, water 0.025000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.025000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.025000 1.000 1.000 

4000093000 40 Chicken, meat 0.025000 1.000 1.000 

4000093001 40 Chicken, meat-babyfood 0.025000 1.000 1.000 

4000094000 40 Chicken, liver 0.025000 1.000 1.000 

4000095000 40 Chicken, meat byproducts 0.025000 1.000 1.000 

4000095001 40 Chicken, meat byproducts-babyfoo 0.025000 1.000 1.000 

4000096000 40 Chicken, fat 0.025000 1.000 1.000 

4000096001 40 Chicken, fat-babyfood 0.025000 1.000 1.000 

4000097000 40 Chicken, skin 0.025000 1.000 1.000 

4000097001 40 Chicken, skin-babyfood 0.025000 1.000 1.000 

5000382000 50 Turkey, meat 0.025000 1.000 1.000 

5000382001 50 Turkey, meat-babyfood 0.025000 1.000 1.000 

5000383000 50 Turkey, liver 0.025000 1.000 1.000 

5000383001 50 Turkey, liver-babyfood 0.025000 1.000 1.000 

5000384000 50 Turkey, meat byproducts 0.025000 1.000 1.000 

5000384001 50 Turkey, meat byproducts-babyfood 0.025000 1.000 1.000 

5000385000 50 Turkey, fat 0.025000 1.000 1.000 

5000385001 50 Turkey, fat-babyfood 0.025000 1.000 1.000 

5000386000 50 Turkey, skin 0.025000 1.000 1.000 

5000386001 50 Turkey, skin-babyfood 0.025000 1.000 1.000 

6000301000 60 Poultry, other, meat 0.025000 1.000 1.000 

6000302000 60 Poultry, other, liver 0.025000 1.000 1.000 

6000303000 60 Poultry, other, meat byproducts 0.025000 1.000 1.000 

6000304000 60 Poultry, other, fat 0.025000 1.000 1.000 

6000305000 60 Poultry, other, skin 0.025000 1.000 1.000 

7000145000 70 Egg, whole 0.025000 1.000 1.000 

7000145001 70 Egg, whole-babyfood 0.025000 1.000 1.000 

7000146000 70 Egg, white 0.025000 1.000 1.000 

7000146001 70 Egg, white (solids)-babyfood 0.025000 1.000 1.000 

7000147000 70 Egg, yolk 0.025000 1.000 1.000 

7000147001 70 Egg, yolk-babyfood 0.025000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.006600 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.006600 1.000 1.000 

9500019000 O Asparagus 0.638000 1.000 0.025 

9500023000 O Banana 0.009500 1.000 1.000 

9500023001 O Banana-babyfood 0.009500 1.000 1.000 

9500024000 O Banana, dried 0.009500 3.900 1.000 

9500024001 O Banana, dried-babyfood 0.009500 3.900 1.000 

9500115000 O Coffee, roasted bean 0.095000 1.000 1.000 

9500116000 O Coffee, instant 0.095000 1.000 1.000 

9500177000 O Grape, leaves 0.009500 1.000 0.025 

9500178000 O Grape, raisin 0.009500 1.000 0.025 

9500263000 O Peanut 0.760000 1.000 0.010 

9500264000 O Peanut, butter 0.760000 1.890 0.010 

9500265000 O Peanut, oil 0.760000 1.000 0.010 

9500283000 O Plantain 0.009500 1.000 1.000 

9500284000 O Plantain, dried 0.009500 3.900 1.000 
Fluazifop-P-butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 19 of 21

Attachment: Chronic Results File (Food + Water)

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for FLUAZIFOP-P-BUTYL NHANES 2003-2008 2-day

Residue file name: C:\Users\wdonovan\Documents\DEEM Version 3.16\122809c 2015.r08

 Adjustment factor #2 used.

Analysis Date 03-30-2015/12:11:31 Residue file dated: 03-30-2015/12:09:19

Reference dose (RfD, Chronic) = .0074 mg/kg bw/day

COMMENT 1: 2015 SLUA

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.001244 16.8%

Hispanic 0.001777 24.0%

Non-Hisp-White 0.001097 14.8%

Non-Hisp-Black 0.001437 19.4%

Non-Hisp-Other 0.001367 18.5%

Nursing Infants 0.000858 11.6%

Non-Nursing Infants 0.001898 25.6%

Female 13+ PREG 0.001478 20.0%

Children 1-6 0.003892 52.6%

Children 7-12 0.001684 22.8%

Male 13-19 0.001233 16.7%

Female 13-19/NP 0.000979 13.2%

Male 20+ 0.000909 12.3%

Female 20+/NP 0.000881 11.9%

Seniors 55+ 0.000919 12.4%

All Infants 0.001577 21.3%

Female 13-50 0.000904 12.2%

Children 1-2 0.004756 64.3%

Children 3-5 0.003705 50.1%

Children 6-12 0.001819 24.6%

Youth 13-19 0.001104 14.9%

Adults 20-49 0.000897 12.1%

Adults 50-99 0.000916 12.4%

Female 13-49 0.000893 12.1%

-------------------------------------------------------------------------------
Fluazifop-P-butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 20 of 21

Attachment: Chronic Results File (Food Only)

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for FLUAZIFOP-P-BUTYL NHANES 2003-2008 2-day

Residue file name: C:\Users\wdonovan\Documents\DEEM Version 3.16\122809cfood 2015.r08

 Adjustment factor #2 used.

Analysis Date 03-30-2015/13:02:49 Residue file dated: 03-30-2015/13:01:41

Reference dose (RfD, Chronic) = .0074 mg/kg bw/day

COMMENT 1: Food only 2015 SLUA

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.001106 14.9%

Hispanic 0.001645 22.2%

Non-Hisp-White 0.000955 12.9%

Non-Hisp-Black 0.001323 17.9%

Non-Hisp-Other 0.001208 16.3%

Nursing Infants 0.000732 9.9%

Non-Nursing Infants 0.001438 19.4%

Female 13+ PREG 0.001348 18.2%

Children 1-6 0.003715 50.2%

Children 7-12 0.001568 21.2%

Male 13-19 0.001138 15.4%

Female 13-19/NP 0.000872 11.8%

Male 20+ 0.000780 10.5%

Female 20+/NP 0.000736 9.9%

Seniors 55+ 0.000786 10.6%

All Infants 0.001220 16.5%

Female 13-50 0.000766 10.4%

Children 1-2 0.004556 61.6%

Children 3-5 0.003537 47.8%

Children 6-12 0.001698 23.0%

Youth 13-19 0.001003 13.6%

Adults 20-49 0.000759 10.3%

Adults 50-99 0.000780 10.5%

Female 13-49 0.000756 10.2%

-------------------------------------------------------------------------------
Fluazifop-P-butyl Dietary Exposure and Risk Assessment DP Number: D426145

Page 21 of 21

Attachment: BEAD SLUA

Date: March 13, 2015

Screening Level Estimates of Agricultural Uses of Fluazifop (122809)

Sorted Alphabetically

Reporting Years: 2004-2013

Annual Average Percent Crop Treated

Crop Lbs. A.I. Average Maximum

1 Alfalfa 1,000 <l <2.5

2 Almonds <500 <1 <2.5

3 Apples <.500 <1 <2.5

4 Apricots <500 <2.5 <2.5

5 Asparagus <500 <2.5 <2.5

6 Blueberries <500 5 5

7 Cabbage <500 <2.5 <2.5

8 Carrots 4,000 15 45

9 Cherries <500 <1 <2.5

10 Corn <500 <1 <2.5

11 Cotton 3,000 <1 <2.5

12 Dry Beans/Peas <500 <1 <2.5

13 Garlic 1,000 10 25

14 Grapefruit 5,000 15 15

15 Grapes 3,000 <2.5 <2.5

16 Nectarines <500 <1 <2.5

17 Onions 4,000 10 25

18 Oranges 1,000 <2.5 <2.5

19 Pasture 2,000 <1 <2.5

20 Peaches 1,000 <2.5 10

21 Peanuts 1,000 <l <2.5

22 Pecans <500 <1 <2.5

23 Peppers <500 <2.5 <2.5

24 Pistachios <500 <l <2.5

25 Plums/Prunes <500 <2.5 <2.5

26 Potatoes <500 <l <2.5

27 Pumpkins <500 <2.5 5

28 Soybeans 100,000 <2.5 5

29 Strawberries <500 <l <2.5

30 SugarBeets <500 <1 <2.5

31 Walnuts <500 <l <2.5