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# 2 ) ll-B- 1 Docket Number: 

# A-83-2 2

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UNITE D STATE S ENVIRONMENTA L PROTECTIO N AGENC Y & ^l^- f ° Offic e o f Ai rQualit yPlannin g an d Standard s ^ „, , % P R0 ^ ° Researc h Triangl e Park , Nort h Carolin a 2771 1 A^ <f"* £ 

### Decembe r 20 , 198 4

MEMORANDU

M SUBJECT : Correspondenc e Pertainin g t o Lea dRis k Assessmen t

Progra m FROM : Joh

n H
. Haines^<&-** /J> A ENVra 

### o*SI $^*&W * Ambien t Standards ' Branch(MD-12 ) AGENC Y TO : Docke t

Numbe r A-83-2 2 D& C ^^^''' CENTRA L DOCKE T Th e attache dletter s wer e sen t t o th e fiv e expert s t o b e e^^Wc r abou t dose-respons e curve s fo r lead-induce dhemoglobin decrement s an d possibl e advers e healt h effect s o f elevate derythrocyt e protoporphyrin
. Attachment sP. 3 

# ARCONN E NATIONA L LABORATOR Y 970 0 SOUTU

CAS S AVENUE , P-ARQONNE , 

### IlliNoi

s 6045 9 TdEpk^ E 512/972

-

Decembe r 13 , 198 4

Dr . Pau l Hammon

d Universit yo f Cincinnat i Kettering Laboratory Cincinnati , O H 4526 7 Dea r Dr . Hammond : Thank yo u fo r agreeing t o participat e i n thi s ver yimportan t stud

y concerning the possibl e healt h effect s o f lea d o n children
. You r judgment s ar e criticall yneede d i n orde r fo r the EP At o complet e a probabilisti c ris k assessmen t o f thes e effects . W e (Dr . TomWallste n o f the Universit yo f Nort h Carolin a an d I ) hav e schedule d meeting wit h yo u o n Thursday , January1 0 a t 9 A.M . Ou r promis e i s t o tr yt o accomplis h a s muc h a s possibl e i n th e mornin g s o tha t littl e o r n o time wil l actuall yb e require d i n th e afternoon . W e ca n affor d t o b e a littl e flexibl e o n thi s poin t because , a s I mentione d i n our phon e conversation , w e wil l obtai n you r "final " judgment s a t a late r date . Finalizing you r judgment s shoul d b e a relativel ystraightforwar d an d quic k tas k i f thing s g o wel l i n ou r initia l session , whic h i s our expectation
. Regardin g the session , tw o issue s ar e ver

yimportant : th e literatur e o n lea d an d it s possibl e healt h effect s an d the proces s o f makin g probabil

isti c judgments
. Th e lea d criteri a document , particularl yChapte r 1 2 an d it s references , i s th e primarysourc e o f information
. However , an yadditiona l o r ne w researc h finding s tha t yo u fee l ar e importan t shoul d als o be considere d t o some degre e a s yo u mak e you r judgments
. Th e proces s o f obtaining/givin g probabilisti c judgment s i s addresse d i n th e protoco l whic h i s enclosed . However , th e actua l mechanic s o f th e proces s i s bette r explaine d i n person , an d To man

d I wil l d o tha t wit h yo u a t th e beginning o f the firs t session
. I f yo u sens e the nee d t o d o so , fee l fre e t o revie w the lead literatur e befor e (or during! ) ou r meeting
. I n addition , i f ther e ar e an yquestion s o r concern s yo u hav e prio r t o the meeting , pleas e contac t eithe r m e o r To m Wallsten . Tom' s phon e numbe r i s (919 ) 962-508 5 an d min e i s (312 ) 972-8430 .

US

. DEPARTMEN T o f ENERQ Y T k UNIVERSIT

Y o f ClniCAq oP. 4



### ' , D 

### . 2 Decembe r 13 , 198 4 Dr . Pau l Hammon d L 

### Again , than k yo u fo r generousl yagreein g t o participat e i n thi s importan t ste p i n th e EPA' s ris k assessment . To mand I ar e ver ymuc h lookin g forwar d t o ou r meeting s wit h yo u o n thes e matters .

Ronal d G . Whitfield , Ph.D . Energ yand Environmenta l System s Divisio n RGW:b f Enclosure s cc : J . Cohe n - EP A J . Haines

- EP A J . Peerenboo m T . Surle s T . Wallste n T . Wolsk oP. 5 

# ARGONN E NATIONA L LABORATOR Y 970 0 SOUTI H CAS S AVENUE , ARQONNE , WiNOi s 6045 9 TdEpk)N E 512/972
-

Decembe r 13 , 198 4

Dr . Julia n Chisol m Baltimore Cit y

Hospita l 494 0 Easter n Avenu e Baltimore , M D 2122 4 Dea r Dr . Chisolm :

Thank yo u fo r agreein g t o participat e i nthi s ver y importan t stud

y concernin g the possibl e healt heffect s o f lead o nchildren . You r judgment s ar e criticall y

neede d i n orde r fo r the EP A t o complet e a probabilisti c ris k assessmen t o f thes e effects .

W e (Dr . Tom

Wallste n o f the Universit y o f Nort hCarolin a an d I ) hav e schedule d meetin g wit hyo u on Friday , Januar y 1 1 at 9 A.M . Ou r promis e i s t o try t o accomplis ha s muc ha s possibl e i nthe mornin g s o tha t littl e o r n o tim e wil l actuall y

b e require d i n the afternoon . W e canaffor d t o be a littl e flexibl e o n thi s poin t because , a s I mentione d i nou r phon e conversation , we wil l obtai n you r "final " judgment s a t a late r date . Finalizin g you r judgment s shoul d be a relativel y straightforwar d an d quic k tas k i f thing s g o wel l i n ou r initia l session , whic hi s our expectation .

Regardin g th e session , tw o issue s ar e ver y important : th e literatur e o nlea d an

d it s possibl e healt heffect s an d th e proces s o f makin g probabil isti c judgments . Th e lead criteri a document , particularl y Chapte r 1 2 an

d it s references , i s the primar y sourc e o f information . However , an y additiona l o r ne w researc hfinding s tha t yo u fee l ar e importan t shoul d als o be considere d t o som e degre e a s yo u make you r judgments . Th e proces s o f obtaining/givin g probabilisti c judgment s i s addresse d i nth e protoco l whic hi s enclosed . However , th e actua l mechanic s o f the proces s i s bette r explaine d i nperson , an d To m an d I wil l d o tha t wit hyo u at the beginnin g o f the firs t session . I f yo u sens e th e nee d t o d o so , fee l fre e t o revie w th e lea d literature before (or during! ) ou r meeting . I naddition , i f ther e ar e an y question s o r concern s yo u hav e prio r t o the meeting , pleas e contac t eithe r m e o r Tom Wallsten . Tom' s phon e numbe r i s (919 ) 962-508 5 an d min e i s (312 ) 972-8430 .

US

. DEPARTMEN To f ENERq yT k UNIVERSIT

Yo f O-HCAQ OP. 6

Dr . Julia n Chisol m2 Decembe r 13 , 198 4 Again , than

k yo u fo r generousl yagreeing t o participat e i n thi s importan t ste

p i n the EPA' s ris k assessment . Toman d I ar e ver

ymuc h looking forward t o our meeting s wit h yo u o n thes e matters . 

### Sincerely , 

# KMJW^ Ronal d G . vfoitfield , Ph.D . Energ yan d Environmenta l System s Divisio n RGW:b f Enclosure s
cc : J . Cohe n - EP A J . Haines

- EPA J . Peerenboom T . Surle s T . Wallste n T . Wolsk oP. 7 

# ARGONN E NATIONA L LABORATOR Y 970 0 SOUTI H CAS S AVENUE , ARQONNE , IlliNoi s 6045 9

Novembe r 27 , 198 4

Dr . Joh n Rose n Head , Divisio n o f Pediatri c Metabolis m Montefior e Hospita l an d Medica l Cente r 11 1 Eas t 21 0 Stree t Bronx , N

Y 1046 7 Dea r Dr . Rosen : Thank yo u fo r agreeing t o participat e i n thi s ver yimportan t stud

y concerning th

e possibl e healt h effect s o f lea d on children
. You r judgment s ar e criticall yneede d i n orde r fo r the EP At o complet e a probabilisti c ris k assessmen t o f thes e effects . W e (Dr . To mWallste n o f the Universit yo f Nort h Carolin a an d I ) hav e tentativel yschedule d meeting wit h yo u on Friday , Decembe r 2 1 a t 9 A.M . Ou r promis e i s t o tr

yt o accomplis h a s muc h a s possibl e i n the morning s o tha t littl e o r n o time wil l actuall ybe require d i n th e afternoon . W e can affor d t o b e a littl e flexibl e on thi s poin t because , a s I mentione d i n m yphon e conversatio n wit h Marily n today , w e wil l obtai n you r "final " judgment s at
- a late r date . Finalizin g you r judgment s shoul d be a relativel ystraightforwar d an d quic k tas k i f thing s g o wel l i n our initia l session , whic h i s ou r expectation
. Regardin g th

e session , two issue s ar e ver yimportant : th e literatur e o n lea d an d it s possibl e healt h effect s an d the proces s o f making probabil

isti c judgments
. Th e lead criteri a document , particularl yChapte r 1 2 an d it s references , i s the primarysourc e o f information
. However , an yadditiona l o r ne w researc h finding s tha t yo u fee l ar e importan t shoul d als o b e considere d t o som e degre e a s yo u mak e you r judgments
. Th e proces s o f obtaining/givin g probabilisti c judgment s i s addresse d i n th e protoco l whic h i s enclosed . However , th

e actua l mechanic s o f the proces s i s bette r explaine d i n person , an d To man

d I wil l d o tha t wit h yo u a t the beginning o f the firs t session
. I f yo u sens e the nee d t o d o so , fee l fre e t o revie w the lead literatur e befor e (or during! ) our meeting
. I n addition , i f ther e ar e an yquestion s o r concern s yo u hav e prio r t o the meeting , pleas e contac t eithe r m e o r To m Wallsten . Tom' s phon e numbe r i s (919 ) 962-508 5 an d min e i s (312)972-8430 .

U.S

. DEPARTMEN T o f ENERQ Y T k UNivERSiT

y o f GHJCAQ OP. 8

Dr . Joh n Rose n 2 Novembe r 27 , 198 4 Again , than

k yo u fo r generousl yagreeing t o participat e i n thi s importan t ste

p i n the EPA' s ris k assessmen t process . To man d I ar e ver

ymuc h lookin g forward t o ou

r meeting wit h yo u on thes e matters .

Sincerely ,

Ronal d G . Whitfield , Ph.D . Energ yan d Environmenta l System s Divisio n RGW:b f Enclosure s
cc : J . Cohe n - EP A J . Haines

- EP A J . Peerenboom T . Surle s T . Wallste n T . Wolsk oP. 9 

# ARGONN E NATIONA L LABORATOR Y 970 0 SOUTI H CAS S AVENUE , ARQONNE , Uliroi s 6045 9

November 20 , 198 4

Dr . Sergi o Piomell i Columbi a Universit

y Medica l Schoo l Divisio n o f Pediatri c Hematolog y an d Oncolog

y Ne w York , N

Y1003 2 Dea r Dr . Piomelli : Than k yo u fo r agreein

g t o participat e I

n thi s ver

y importan

t stud y concernin

g th e possibl e healt heffect s o f lea d o nchildren . You

r judgment s are critically

neede d i norder fo

r th e EP A to complet e a probabilisti c ris k assessment o

f thes e effects . W e (Dr . To

m Wallsteno

f th e University

o f NorthCarolin

a an d I ) hav

e tentatively

schedule

d meetin

g wit hyo

u o nTuesday , Decembe r 1 8 fro m 1 P.M . to 5 P.M . an

d Wednesday , December 1 9 fro m 9 A.M . to 1 2 P.M . Our promis e I s to tr y to accomplis ha s muc ha s possibl e inth e Tuesda

y sessio ns o tha

t littl e o

r n o tim e wil l actuall y

b e require

d o nWednesda

y morning . W

e ca naffor d to b e a littl e flexibl e o

nthi s poin

t because , a s I mentione d inou

r phon e conver satio no nNovembe r 6th , w e wil l obtai nyou r "final " judgment s a t a later date . Finalizin

g you r judgment s shoul d b e a relativel y

straightforwar

d an d quic k tas k i f thing s go wel l inou r Initia l session , whichI s ou r expectation . Regardin

g th e session , tw

o issue s ar

e ver y important : th

e literatur e o nlea d an d it s possibl e healtheffect s an d th e proces s o

f makin g probabil isti c judgments . Th e lea d criteri a document , particularl y Chapte r 1 2 an

d it s references , i s th

e primar

y sourc e o

f information . However , an y additiona l o

r ne w researc

hfinding s that yo

u fee l are important shoul d als o b e considere

d to som e degre e a s yo

u mak e you r judgments . The proces s o f obtaining/givin

g probabilisti c judgment s I s addresse d in th

e protoco l whichi s enclosed . However , th

e actua l mechanic s of th e proces s I s better explaine d In person , an d To m an d I wil l d

o that wit hyo

u a t th e beginnin

g o f th e firs t session . I f yo u sens e th

e nee d to d o so , fee l free t

o revie w th e lea d literatur e before (o

r during! ) ou

r meeting . Inaddition , I f there ar e an y question s o

r concern s yo

u hav e prior to th

e meeting , pleas e contac t eithe r m e o r To m Wallsten . Tom' s phon e number i s (919 ) 962-508 5 an d min e I s (312 ) 972-8430 .

U S DEPARTMEN To f ENERq yT k

UNivERSiT

yo f GHJCACJ OP.1 0

Dr . Sergi o Piomell i 2 November 20 , 198 4

* * Again , than k yo u fo r generousl y

agreein

g t o participat e In thi s importan

t ste p inth e EPA' s ris k assessment . To m an d I ar e ver y muc hlookin

g forwar d to ou r meeting s withyo

u o nthes e matters . Sincerely , 

# 4^A^'
Ronal d G . Whitfield , Ph.D . Energ y an d Environmenta l System s Divisio

n RGW:bf Enclosure s
cc : J . Cohen- EP

A J . Haines - EP

A J . Peerenboo

m T . Surle s T . Wallsten T . WolskoP.1 1 

# ARCONN E NATIONA L LABORATOR Y 970 0 SOUTI H CAS S AVENUE , ARQONNE , IlliNOi s 6045 9

Novembe r 20 , 198 4

Dr . Bernar

d Davido

w Assistan t Commissione r Ne w York Cit

y Department o

f Healt h 45 5 Firs t Avenue , Roo m 127 3 Ne w York , N

Y1001 6 Dear Dr . Davidow : Than k yo u fo r agreein

g to participat e inthi s ver y importan

t stud y concernin

g th e possibl e healtheffect s o f lea d o nchildren . You

r judgment s are criticall y

neede d i norder fo

r th e EP A to complet e a probabilisti c ris k assessment o

f thes e effects . W e (Dr . To

m Wallsteno

f th e University

o f Nort hCarolin

a an d I ) hav

e tentativel y

schedule

d meetin

g wit hyo

u on - Wednesday , Decembe r 2 0 fro m 1 P.M . to 5 P.M . an

d Thursday , December 2 0 fro m 9 A.M . to 1 2 P.M . Ou r promis e i s to tr y t o accomplis ha s muc ha s possibl e inth e Wednesda

y sessio ns o that littl e o r n o tim e wil l actuall y

b e require

d o nThursda

y morning . W

e ca naffor d t o b e a littl e flexibl e o nthi s poin

t because , a s I mentione d inou

r phon e conver satio no nNovembe r 6th , w e wil l obtai nyou r "final " judgment s a t a later date . Finalizin

g you r judgment s shoul d b e a relativel y

straightforwar

d an d quic k tas k i f thing s g o wel l inou

r initia l session , whichi s ou r expectation . Regardin

g th e session , tw

o issue s are ver

y important : th

e literatur e o nlea d an d it s possibl e healtheffect s an d th e proces s of makin g probabil isti c judgments . Th e lea d criteri a document , particularl y Chapte r 1 2 an

d It s references , i s th

e primar

y sourc e of information . However , an y additiona l o

r ne w researc

hfinding s that yo

u fee l are important shoul d als o b e considere

d t o som e degre e a s yo

u mak e you r judgments . The proces s o f obtaining/givin

g probabilisti c judgment s i s addresse d In th

e protoco l whichi s enclosed . However , th

e actua l mechanic s o f th e proces s i s better explaine d inperson , an d To m an d I wil l d

o that wit hyo

u a t th e beginnin

g o f th e firs t session . I f yo u sens e th

e nee d t o d o so , fee l free t

o revie w th e lea d literatur e before (o

r during! ) ou

r meeting . Inaddition , i f there are an y question s o

r concern s yo

u hav e prior to th

e meeting , pleas e contac t either m e o r To m Wallsten . Tom' s phon e number i s (919 ) 962-508 5 an d min e i s (312)972-8430 .

U.S

. DEPARTMEN T o f ENERQ Y T k UNivERSiT

y o f GHJCAQ OP.1 2

Dr . Bernar

d Davido

w 2 November 20 , 198 4 Again , than

k yo u fo r generousl y

agreein

g t o participat e i nthi s important ste

p inth

e EPA' s ris k assessment . To m an d I ar e ver y muc hlookin

g forwar d to ou r meeting s withyo

u o nthes e matters . 

### Sincerely , 

# faiMxfr^
Ronal d G . Whitfield , Ph.D . Energ y an d Environmenta l System s Divisio

n RGW:bf Enclosure s
cc : J . Cohe

n- EP A J . Haines - EP

A J . Peerenboo

m T . Surle s T . Wallsten T . Wolsko