UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

MEMORANDUM 

Date: 14-November-2013 

SUBJECT: Fenoxaprop-p-ethyl. Chronic Aggregate Dietary (Food and Drinking Water) 

Exposure and Risk Assessment for Registration Review and a New Use on Grass 

Hay. 

PC Code: 129092 

Decision No.: 466648, 4 7791 I 

DP Barcode: 0 415999, 0416002 

Registration No.: 264-666, 264-1 073, 264-

653 

Petition No.: 2£805 1 Regulatory Action: Section 3 Registration, 

Registration Review 

Risk Assessment Type: Dietary Case No.: NA 

TXR No.: NA CAS No.: 71283-80-2 

MRID No.: NA 40 CFR: 180.430 

FROM: Donald Wilbur, Chemist ~ W~ Risk Assessment Branch VI 

Health Effects Division (HED, 7509P) 

THROUGH: Sheila Piper, Senior Chern~ 

Seyed Tadayon, Chemist~ ~~P 

Dietary Exposure Science isory Council (DESAC) 

TO: Christopher Schlosser, Risk Assessor 

Registration Branch VI 

Health Effects Division (7509P) 

Andrew Ertman! Barbara Madden, Risk Managers 

Risk Integration Minor Use, and Emergency Response Branch 

Registration Division (7505C) 

Molly Clayton, Chemical Review Manager 

Risk Management and Implementation Branch III 

Pesticide Re-evaluation Division (7508P) 

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Fenoxaprop-p-ethyl Dietary Exposure and Risk Assessment DP Number: D415999, D416002

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Executive Summary

A chronic aggregate dietary food and drinking water exposure and risk assessment was

conducted using the Dietary Exposure Evaluation Model software with the Food Commodity 

Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food consumption 

data from the U.S. Department of Agriculture’s (USDA’s) National Health and Nutrition 

Examination Survey, What We Eat in America, (NHANES/WWEIA). The analysis was 

conducted in support of a human-health risk assessment for the proposed Section 3 use of 

fenoxaprop-p-ethyl on grass hay as well as for the registration review process (D. Wilbur, 

D415998). This memorandum was reviewed by two peer reviewers of the DESAC per DESAC 

Standard Operating Procedure (SOP) 2012.1. 

The unrefined chronic analysis is based on tolerance-level residues, 100% crop treated (%CT)

assumptions, and DEEM default processing factors. Using assumptions considered to be highly 

protective of human health, the chronic dietary risk estimates for food and water range from 

approximately 8.9% of the chronic population adjusted dose (cPAD) for youths 13-19 to 27.5% 

of the cPAD for all infants. The general U.S. population utilized 11.7% of the cPAD. Generally, 

HED is concerned when dietary risk estimates exceed 100% of the PAD; therefore, the chronic 

dietary risk estimates for fenoxaprop-p-ethyl are below HED’s level of concern (LOC) for all 

population subgroups, including those comprised of infants and children.

No acute dietary exposure and risk analysis was performed since there were no appropriate 

studies that demonstrated evidence of toxicity attributable to a single dose for either the general 

population or for females 13-49 years of age.

Additionally, no cancer exposure and risk analysis was performed since quantification of risk 

using a non-linear approach (i.e., RfD) for FPE will adequately account for all chronic toxicity, 

including carcinogenicity, that could result from exposure to FPE.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For chronic 

assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose 

that HED has concluded will result in no unreasonable adverse health effects). This dose is 

referred to as the population-adjusted dose (PAD). The PAD is equivalent to the point of 

departure (POD, no observed adverse effect level (NOAEL), lowest observed adverse effect 

level (LOAEL), e.g.) divided by the required uncertainty or safety factors.

For non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% 

of the PAD. References that discuss chronic risk assessments in more detail are available on the 

EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A 

User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPAPEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG-1999).

This dietary assessment is being performed for a new use on grass grown for seed as well as for 

all registered uses to support registration review.
Fenoxaprop-p-ethyl Dietary Exposure and Risk Assessment DP Number: D415999, D416002

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The last dietary assessment for FPE was conducted in 1998 in conjunction with a new use on 

barley.

II. Residue Information

Fenoxaprop-p-ethyl [FPE; (+)-ethyl 2-[4-[(6-chloro-2-benzoxazolyl)oxy]phenoxy]propanoate, 

PC Code 129092] is a selective aryloxyphenoxypropionate herbicide used to control grass weeds 

after emergence. FPE is currently registered for use on barley, cotton, rice, soybeans, and wheat.

FPE is also registered for non-agricultural use on conservation reserves, ornamentals, rights-ofway, and turf. IR-4 is requesting a new tolerance be established on grass, hay to support a new 

use on grass grown for seed. A summary of the tolerances for FPE are shown below in Table 1.

Table 1. Tolerance Summary for FPE

Commodity Residue (ppm)

Barley, grain 0.05

Barley, straw 0.1

Cattle, fat 0.05

Cattle, meat byproducts 0.05

Cattle, meat 0.05

Cotton, undelinted seed 0.05

Goat, fat 0.05

Goat, meat byproducts 0.05

Goat, meat 0.05

Hog, fat 0.05

Hog, meat byproducts 0.05

Hog, meat 0.05

Horse, fat 0.05

Horse, meat byproducts 0.05

Horse, meat 0.05

Milk 0.02

Peanut 0.05

Peanut, hulls 0.05

Rice, grain 0.05

Sheep, fat 0.05

Sheep, meat byproducts 0.05
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Sheep, meat 0.05

Soybean 0.05

Wheat, grain 0.05

Wheat, straw 0.50

Section 18 emergency exemptions

Grass, forage 0.05 ppm (expires 12/31/13)

Grass, hay 0.05 ppm (expires 12/31/13)

The residue(s) of concern for both the tolerance expression and risk assessment in plants and 

animals is fenoxaprop-ethyl, (±)-ethyl 2-[4-[(6-chloro-2-benzoxazolyl)oxy]phenoxy]propanoate, 

and its metabolites, 2-[4-[(6-chloro-2-benzoxazolyl)oxy]phenoxy]propanoic acid and 6-chloro2,3-dihydrobenzoxazol-2-one, calculated as the stoichiometric equivalent of fenoxaprop-ethyl. It 

is important to note that while the tolerance is in terms of fenoxaprop-ethyl (a 50:50 racemic 

mixture of d and l enantiomers), it is protective for all uses of fenoxaprop-p-ethyl (95% d and 5% 

l enantiomers) since both the data-collection and enforcement methods are not stereospecific and 

cannot determine the different between the two compounds.

The chronic dietary exposure and risk estimates are considered unrefined since they assume 

tolerance levels, 100% CT, and use DEEMTM default processing factors.

The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009, 

and 2010. Over this 3-year period, PDP analyzed 1479 samples of catfish for fenoxaprop-p-ethyl

residues. None of the samples contained detectable residues. As a result, residues in fish were 

not included in the assessment.

III. Percent Crop Treated Information

The chronic analysis was performed assuming 100% of each crop was treated with fenoxapropp-ethyl (i.e., 100% CT).

IV. Drinking Water Data

A screening-level drinking water assessment (DWA) for fenoxaprop-p-ethyl was conducted in 

support of registration review and the IR-4 petition 2E8051 for use on grass grown for seed (C. 

Peck, D411291, D404234, 09/25/2013). Fenoxaprop-p-ethyl [FPE; (+)-ethyl 2-[4-[(6-chloro-2-

benzoxazolyl)oxy]phenoxy]propanoate, PC Code 129092] is a selective 

aryloxyphenoxypropionate herbicide used to control grass weeds after emergence. FPE is 

currently registered for use on barley, cotton, rice, soybeans, and wheat, and is registered for 

non-agricultural use on conservation reserves, ornamentals, rights-of-way, and turf. This 

assessment is based on available environmental fate data. There are no significant data gaps in 

the environmental fate database. There are no existing monitoring data for FPE or its degradates.

The maximum application rate for the foliar uses is for ornamentals, rights-of-way, and turf, at 

0.173 lbs a.i./acre/application, applied with a 14-day reapplication interval and a maximum total 

annual application rate of 0.531 lb a.i./A/yr. The maximum proposed application rate for the 
Fenoxaprop-p-ethyl Dietary Exposure and Risk Assessment DP Number: D415999, D416002

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proposed new grass grown for seed use is 0.083 lbs a.i./acre/application, applied one time per 

year for a maximum total annual application rate of 0.083 lb a.i./A/yr. Use on rice was also 

evaluated, as managed aquatic releases from rice paddies impact receiving water hydrology and 

chemistry differently than rainfall-driven runoff from more-typical agricultural land. The 

maximum proposed application rate for rice use is 0.108 lbs a.i./A/application, applied twice per 

year with a 14-day reapplication interval, with a maximum total annual application rate of 0.188 

lb a.i./A/yr.

FPE is partially soluble in water, dissolving at 0.7 mg/L at 20°C and pH 5.8. FPE residues are 

considered moderately mobile. The compound is not expected to volatilize significantly due to 

its low vapor pressure of 1.4 x 10-8torr (20°C). The octanol-water partition coefficient of FPE is 

38,000, with a relatively high bioconcentration factor (BCF) observed in fish viscera (1021x) 

compared to the edible fish portions (129x). The BCF for whole fish portions was 510x, which 

does not exceed reporting thresholds for concern for bioconcentration.

FPE is hydrolyzed moderately rapidly in acidic conditions (t1⁄2 = 19.6 d at pH 5) and neutral 

conditions (t1⁄2 = 24.6 d at pH 7), and quickly in alkaline conditions (t1⁄2 = 0.7 d at pH 9). Two 

major hydrolytic degradates were identified: fenoxaprop-p acid (AE F088406) and 

chlorobenzoxazolone (AE F054014). Both FPE and fenoxaprop-p acid may hydrolyze to 

chlorobenzoxazolone, which was observed in the hydrolysis study at up to 64% of the applied at 

pH 5(30 DAT), 23% of the applied at pH 7 (30 DAT), and 20% of the applied at pH 9 (30 DAT). 

When considering the combined residues however, they were stable to hydrolysis at all pHs. 

FPE also degrades quickly via aqueous photolysis, with an estimated half-life of 0.95 days. FPE 

was quickly biodegraded in aerobic soils (t1⁄2 ≤ 1.63 d), in aerobic aquatic systems (t1⁄2 < 1 d) and 

in anaerobic aquatic systems (t1⁄2 ≤ 2.4 d). 

The computer models PRZM and EXAMS and the Tier I Rice model were used to generate 

surface water EDWCs for use in the human health dietary risk assessment, while the PRZM-GW 

and SCI-GROW models were used to generate groundwater EDWCs. In 2007, the Health 

Effects Division (HED) identified FPE and its two degradates, fenoxaprop-p acid ((D+)-2-[4-(6-

chloro-2-benzoxazolyloxy) phenoxy] propanoate, AE F088406) and chlorobenzoxazolone (4-(6-

chloro-2-benzoxazolyloxy) phenol, AE F054014), as residues of concern in drinking water 

because these residues retained the 6-chloro-2-benzoxazol moiety. Newly submitted 

environmental fate studies indicated that a fourth degradate, 4-(6-chloro-2-benzoxazolyloxy) 

phenol (AE F040356), also contained the 6-chloro-2-benzoxazol moiety. This degradate was 

included as a residue of concern, so the parent plus the three degradates were assessed using a 

total toxic residue (TTR) approach. Additionally, as high levels (e.g., >20%) of non-extracted 

residues (NER) were found in all environmental fate studies and these NER were found to 

contain levels of two degradates of concern (fenoxaprop-p acid and chlorobenzoxazolone) when 

subjected to harsh mineral acid extraction, NER were also included in the TTR approach. 

However, it is uncertain as to how available these residues are to reaching surface water and 

groundwater drinking water sources. As such, EFED modeled FPE TTR with and without NER 

to bracket the EDWCs. Descriptions of the models are available at the EPA internet site: 

http://www.epa.gov/oppefed1/models/water/.
Fenoxaprop-p-ethyl Dietary Exposure and Risk Assessment DP Number: D415999, D416002

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The maximum acute and chronic surface EDWCs (110 and 69 μg/L, respectively) were 

associated with application to rice. Surface water EDWCs for the proposed new use of grass 

grown for seed were much lower than the maximum values (acute EDWC of 1.65 μg/L and a 

chronic EDWC of 0.62 μg/L). For groundwater sources of drinking water, the maximum acute 

and chronic estimated concentrations of FPE TTR in shallow groundwater from PRZM-GW for 

applications to turf were 0.17 and 0.032 μg/L, respectively. The maximum groundwater EDWC 

reported from SCI-GROW was 0.096 μg/L for the chemical’s use on turf. Maximum EDWCs 

for FPE residues in surface water and groundwater recommended for dietary assessment are 

presented in Table 2. Water residues were incorporated in the DEEM-FCID into the food 

categories “water, direct, all sources” and “water, indirect, all sources.” 

Table 2. Maximum EDWCs of FPE (plus toxic degradates)

DRINKING 

WATER 

SOURCE 

(MODEL 

USED)

USE (rate modeled) MAXIMUM ESTIMATED

DRINKING WATER 

CONCENTRATION (EDWC) 

(ppb)

1-in-10 year 

acute 

(μg/L)

1-in-10 year 

chronic (μg/L)

Surface water

(Tier I Rice 

Model)

Foliar Rice

(first app at 0.108 lbs a.i./A, 14 

day RTI, second app at 0.034 lbs 

a.i./A, third app at 0.046 lbs 

a.i./A)

110 68.6

Groundwater 

(PRZM-GW)

Aerial Foliar 

(turf, 0.173 lbs a.i./A x 3, RTI = 

14 days, fourth app at 0.012 lbs 

a.i./A)

0.17 0.032

V. DEEM-FCID Program and Consumption Information

The fenoxaprop-p-ethyl chronic dietary exposure assessment was conducted using the DEEMFCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA’s 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups. Based on analysis 

of the 2003-2008 WWEIA consumption data, which took into account dietary patterns and 

survey respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, 

children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years 

old.
Fenoxaprop-p-ethyl Dietary Exposure and Risk Assessment DP Number: D415999, D416002

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For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

VI. Toxicological Information

Fenoxaprop-ethyl (HOE 033171; FE) was first registered as a racemic mixture of D/L isomers. 

Since registration, the more biologically active isomer D+, fenoxaprop-p-ethyl (HOE 046360; 

FPE) has been registered. ToxSAC/HASPOC found that the toxicological effects of FE and FPE 

across species, duration, and route of exposure are remarkably similar. It was, therefore, 

concluded that the similarity between the FE and FPE data was such that the database for FE 

could be bridged with FPE.

FPE has low acute toxicity following the oral, dermal, and inhalation routes of exposure. No 

evidence of reproductive or neurological toxicity was identified in the database. The major 

target organs following short-term and long-term oral administration of FE and FPE in rats and 

mice are the liver and kidneys, with rats being the most sensitive species. The primary toxic 

effect is altered lipid metabolism characterized by decreased lipids and cholesterol, and increased 

liver weights in rats and slightly increased lipids, cholesterol and proteins and increases liver 

weights in mice. In mice, a treatment-related increase in tumor incidence of hepatocellular 

adenomas and carcinomas, mainly adenomas, was observed in males. There was, however, no 

evidence of a mutagenic effect in a comprehensive battery of genetic toxicology assays with both 

isomers. In accordance with EPA’s Final Guidelines for Carcinogen Risk Assessment (2005), 

CARC classified FE/FPE as “Suggestive Evidence of Carcinogenic Potential”. No evidence of 

tumors was identified in rats 

An acute reference dose has not been established for either the general population or for females 

13-49 years of age since there were no appropriate studies that demonstrated evidence of toxicity 

attributable to a single dose for these populations. For chronic dietary exposure and risk 

assessment, the chronic/carcinogenicity and 2-generation reproductive toxicity studies in rats, 

conducted on the FE, were selected with a NOAEL of 1.5 mg/kg/day identified in both studies.

The LOAEL is 9 mg/kg/day based on decreased serum lipids and cholesterol, and changes in 

liver weights in both studies, as well as increased ALP and liver weights in pups from the 2-

generation reproductive toxicity study. 

The FQPA factor may be reduced to 1X based on adequate toxicity database and exposure data. 

There is no evidence of susceptibility/sensitivity and there are no residual uncertainties 

concerning pre- or post-natal toxicity. No evidence of neurotoxicity was identified throughout 

the database for FE or FPE. All endpoints used in this risk assessment are protective of 

developmental effects in FE and FPE.
Fenoxaprop-p-ethyl Dietary Exposure and Risk Assessment DP Number: D415999, D416002

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A summary of the toxicological doses and endpoints for FPE for use in dietary exposure 

assessments is presented in Table 3.

Table 3. Toxicological Doses and Endpoints for FPE for Use in Dietary Health Risk Assessments

Exposure/

Scenario

Point of 

Departure

Uncertainty/

FQPA Safety 

Factors

RfD/PAD, 

Level of 

Concern for 

Risk 

Assessment

Study and Toxicological Effects

Acute Dietary 

(General 

Population) No appropriate endpoint attributable to a single dose was identified. An acute RfD was 

Acute Dietary not established.

(Females 13-49 

years of age)

Chronic Dietary 

(All Populations)

NOAEL = 1.5 

mg/kg/day

UFA 10x

UFH 10x

FQPA SF = 

1X

Chronic RfD 

= 0.015 

mg/kg/day

cPAD = 

0.015 

mg/kg/day

Chronic Toxicity/Carcinogenicity (rat)

MRIDs: 00149664, 0149665, 

00151564, 00151565

2-Generation Reproductive Toxicity 

(rat)

MRID: 00159920

LOAEL = 9 mg/kg/day, based on 

decreased serum lipids and cholesterol, 

and altered liver weights

Cancer (oral)

Classification: "Suggestive evidence of carcinogenic potential"; quantification of risk 

using a non-linear approach; i.e., RfD, for FPE will adequately account for all chronic 

toxicity, including carcinogenicity, that could result from exposure to FPE.

Point of Departure (POD) = A data point or an estimated point derived from observed dose-response data and used to mark the beginning 

of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse 

effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UFA = extrapolation from animals to humans 

(interspecies). UFH = potential variation in sensitivity among members of the human population (intraspecies). FQPA SF = FQPA 

Safety Factor. cPAD = chronic population adjusted dose. RfD = reference dose. N/A = not applicable. 

VII. Results/Discussion

As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% of 

the cPAD. The DEEM-FCID analyses estimate the dietary exposure and risk of the U.S. 

population and various population subgroups. The results reported in Table 4(a-c) below are for 

the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, 

youth 13-19, females 13-49, adults 20-49, and adults 50-99 years. Combined chronic dietary 

exposure estimates for food and drinking water are below HED’s level of concern for all 

population subgroups, including those of infants and children. The most highly exposed 

population subgroup is all infants at 27.5% of the cPAD, while the general U.S. population 

utilized 11.7% of the cPAD. 
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Table 4a. Summary of Estimated Dietary (Food + Drinking Water) Exposures and Risk for 

Fenoxaprop-p-ethyl

Population Subgroup cPAD, 

mg/kg/day

Chronic Estimates

Exposure, mg/kg/day Risk, 

% cPAD

U.S. Population

0.015

0.001757 11.7

All infants (< 1 year) 0.004121 27.5

Children 1-2 yrs 0.003361 22.4

Children 3-5 yrs 0.002634 17.6

Children 6-12 yrs 0.001810 12.1

Youth 13-19 yrs 0.001340 8.9

Adults 20-49 yrs 0.001671 11.1

Adults 50-99 yrs 0.001617 10.8

Females 13-49 yrs 0.001646 11.0

*The subpopulation(s) with the highest risk estimates are bolded.

Table 4b. Summary of Estimated Dietary (Food Only) Exposures and Risk for Fenoxaprop-p-ethyl

Population Subgroup cPAD, 

mg/kg/day

Chronic Estimates

Exposure, mg/kg/day Risk, 

% cPAD

U.S. Population

0.015

0.000321 2.1

All infants (< 1 year) 0.000417 2.8

Children 1-2 yrs 0.001288 8.6

Children 3-5 yrs 0.000888 5.9

Children 6-12 yrs 0.000551 3.7

Youth 13-19 yrs 0.000292 1.9

Adults 20-49 yrs 0.000238 1.6

Adults 50-99 yrs 0.000200 1.3

Females 13-49 yrs 0.000218 1.5

*The subpopulation(s) with the highest risk estimates are bolded. 

Table 4c. Summary of Estimated Dietary (Drinking Water Only) Exposures and Risk for 

Fenoxaprop-p-ethyl

Population Subgroup cPAD, 

mg/kg/day

Chronic Estimates

Exposure, mg/kg/day Risk, 

% cPAD

U.S. Population

0.015

0.001436 9.9

All infants (< 1 year) 0.003704 24.7

Children 1-2 yrs 0.002072 13.8

Children 3-5 yrs 0.001746 11.6

Children 6-12 yrs 0.001259 8.4

Youth 13-19 yrs 0.001047 7.0

Adults 20-49 yrs 0.001433 9.6

Adults 50-99 yrs 0.001417 9.4

Females 13-49 yrs 0.001428 9.5

*The subpopulation(s) with the highest risk estimates bolded. 
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VIII. Characterization of Inputs/Outputs

This chronic dietary exposure and risk analysis is based on tolerance-level residues, 100% crop 

treated assumptions, and default processing factors. As the exposure estimates to all population 

subgroups are below HED’s level of concern, it was not necessary to make refinements. If it had 

been necessary to refine the analysis, field trial residue values could have been used in place of 

tolerance level residues and percent crop treated could have been incorporated.

IX. Conclusions

This unrefined analysis demonstrates that the existing and proposed use of fenoxaprop-p-ethyl

will not result in chronic dietary risk estimates (food plus drinking water) that exceed HED’s 

level of concern for any of the regulated populated subgroups, including those comprised of 

infants and children. 

HED is confident that the assessment does not underestimate risk to the general U.S. population 

or any population subgroup. There are no dietary risk considerations relating to the proposed or 

existing uses of fenoxaprop-p-ethyl.
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X. List of Attachments

• Chronic Residue Input File

• Chronic Results Files

Attachment 1: Chronic Food plus Water Residue Input File

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for FENOXAPROP-P-ETHYL

Residue file: C:\Documents and Settings\dwilbur\My Documents\DEEM 

Files\FPE\FPE_chronic.r08

 Adjust. #2 used

Analysis Date 11-06-2013 Residue file dated: 11-06-2013/08:22:34

Reference dose (RfD) = 0.015 mg/kg bw/day

Comment:FPE chronic tolerance 100%CT cPAD=0.015

----------------------------------------------------------------------------------

Food Crop Residue Adj.Factors

EPA Code Grp Food Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------

1500025000 15 Barley, pearled barley 0.050000 1.000 1.000 

1500025001 15 Barley, pearled barley-babyfood 0.050000 1.000 1.000 

1500026000 15 Barley, flour 0.050000 1.000 1.000 

1500026001 15 Barley, flour-babyfood 0.050000 1.000 1.000 

1500027000 15 Barley, bran 0.050000 1.000 1.000 

3100044000 31 Beef, meat 0.050000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.050000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.050000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.050000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 0.050000 1.000 1.000 

3100047000 31 Beef, fat 0.050000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.050000 1.000 1.000 

3100048000 31 Beef, kidney 0.050000 1.000 1.000 

3100049000 31 Beef, liver 0.050000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 0.050000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.050000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.050000 1.000 1.000 

3200169000 32 Goat, meat 0.050000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.050000 1.000 1.000 

3200171000 32 Goat, fat 0.050000 1.000 1.000 

3200172000 32 Goat, kidney 0.050000 1.000 1.000 

3200173000 32 Goat, liver 0.050000 1.000 1.000 

3300189000 33 Horse, meat 0.050000 1.000 1.000 

3600222000 36 Milk, fat 0.020000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.020000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.020000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.020000 1.000 1.000 

3600224000 36 Milk, water 0.020000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.020000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.020000 1.000 1.000 

9500263000 O Peanut 0.050000 1.000 1.000 

9500264000 O Peanut, butter 0.050000 1.890 1.000 

9500265000 O Peanut, oil 0.050000 1.000 1.000 

3400290000 34 Pork, meat 0.050000 1.000 1.000 

3400290001 34 Pork, meat-babyfood 0.050000 1.000 1.000 

3400291000 34 Pork, skin 0.050000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.050000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.050000 1.000 1.000 

3400293000 34 Pork, fat 0.050000 1.000 1.000 

3400293001 34 Pork, fat-babyfood 0.050000 1.000 1.000 
Fenoxaprop-p-ethyl Dietary Exposure and Risk Assessment DP Number: D415999, D416002

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3400294000 34 Pork, kidney 0.050000 1.000 1.000 

3400295000 34 Pork, liver 0.050000 1.000 1.000 

1500323000 15 Rice, white 0.050000 1.000 1.000 

1500323001 15 Rice, white-babyfood 0.050000 1.000 1.000 

1500324000 15 Rice, brown 0.050000 1.000 1.000 

1500324001 15 Rice, brown-babyfood 0.050000 1.000 1.000 

1500325000 15 Rice, flour 0.050000 1.000 1.000 

1500325001 15 Rice, flour-babyfood 0.050000 1.000 1.000 

1500326000 15 Rice, bran 0.050000 1.000 1.000 

1500326001 15 Rice, bran-babyfood 0.050000 1.000 1.000 

3500339000 35 Sheep, meat 0.050000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.050000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.050000 1.000 1.000 

3500341000 35 Sheep, fat 0.050000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.050000 1.000 1.000 

3500342000 35 Sheep, kidney 0.050000 1.000 1.000 

3500343000 35 Sheep, liver 0.050000 1.000 1.000 

0600347000 6 Soybean, seed 0.050000 1.000 1.000 

0603348000 6C Soybean, flour 0.050000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 0.050000 1.000 1.000 

0600349000 6 Soybean, soy milk 0.050000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 0.050000 1.000 1.000 

0600350000 6 Soybean, oil 0.050000 1.000 1.000 

0600350001 6 Soybean, oil-babyfood 0.050000 1.000 1.000 

1500381000 15 Triticale, flour 0.050000 1.000 1.000 

1500381001 15 Triticale, flour-babyfood 0.050000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.068600 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.068600 1.000 1.000 

1500401000 15 Wheat, grain 0.050000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.050000 1.000 1.000 

1500402000 15 Wheat, flour 0.050000 1.000 1.000 

1500402001 15 Wheat, flour-babyfood 0.050000 1.000 1.000 

1500403000 15 Wheat, germ 0.050000 1.000 1.000 

1500404000 15 Wheat, bran 0.050000 1.000 1.000 

0601349500 6AB Soybean, vegetable 0.050000 1.000 1.000 
Fenoxaprop-p-ethyl Dietary Exposure and Risk Assessment DP Number: D415999, D416002

Page 13 of 15

Attachment 2a: Chronic Results File (Food and Drinking Water)

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for FENOXAPROP-P-ETHYL NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\dwilbur\My Documents\DEEM 

Files\FPE\FPE_chronic.r08

 Adjustment factor #2 used.

Analysis Date 11-06-2013/08:24:09 Residue file dated: 11-06-2013/08:22:34

Reference dose (RfD, Chronic) = .015 mg/kg bw/day

COMMENT 1: FPE chronic tolerance 100%CT cPAD=0.015

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.001757 11.7%

Hispanic 0.001736 11.6%

Non-Hisp-White 0.001793 12.0%

Non-Hisp-Black 0.001464 9.8%

Non-Hisp-Other 0.002021 13.5%

Nursing Infants 0.001460 9.7%

Non-Nursing Infants 0.005309 35.4%

Female 13+ PREG 0.001610 10.7%

Children 1-6 0.002849 19.0%

Children 7-12 0.001711 11.4%

Male 13-19 0.001317 8.8%

Female 13-19/NP 0.001363 9.1%

Male 20+ 0.001585 10.6%

Female 20+/NP 0.001707 11.4%

Seniors 55+ 0.001587 10.6%

All Infants 0.004121 27.5%

Female 13-50 0.001647 11.0%

Children 1-2 0.003361 22.4%

Children 3-5 0.002634 17.6%

Children 6-12 0.001810 12.1%

Youth 13-19 0.001340 8.9%

Adults 20-49 0.001671 11.1%

Adults 50-99 0.001617 10.8%

Female 13-49 0.001646 11.0%
Fenoxaprop-p-ethyl Dietary Exposure and Risk Assessment DP Number: D415999, D416002

Page 14 of 15

Attachment 2b: Chronic Results File (Food Only)

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for FENOXAPROP-P-ETHYL NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\dwilbur\My Documents\DEEM 

Files\FPE\FPE_chronic_foodonly.r08

 Adjustment factor #2 used.

Analysis Date 11-12-2013/07:56:33 Residue file dated: 11-12-2013/07:56:02

Reference dose (RfD, Chronic) = .015 mg/kg bw/day

COMMENT 1: FPE chronic tolerance 100%CT cPAD=0.015

FOOD ONLY

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.000321 2.1%

Hispanic 0.000365 2.4%

Non-Hisp-White 0.000316 2.1%

Non-Hisp-Black 0.000279 1.9%

Non-Hisp-Other 0.000366 2.4%

Nursing Infants 0.000161 1.1%

Non-Nursing Infants 0.000531 3.5%

Female 13+ PREG 0.000258 1.7%

Children 1-6 0.001010 6.7%

Children 7-12 0.000514 3.4%

Male 13-19 0.000330 2.2%

Female 13-19/NP 0.000256 1.7%

Male 20+ 0.000247 1.6%

Female 20+/NP 0.000198 1.3%

Seniors 55+ 0.000198 1.3%

All Infants 0.000417 2.8%

Female 13-50 0.000217 1.4%

Children 1-2 0.001288 8.6%

Children 3-5 0.000888 5.9%

Children 6-12 0.000551 3.7%

Youth 13-19 0.000292 1.9%

Adults 20-49 0.000238 1.6%

Adults 50-99 0.000200 1.3%

Female 13-49 0.000218 1.5%

-------------------------------------------------------------------------------
Fenoxaprop-p-ethyl Dietary Exposure and Risk Assessment DP Number: D415999, D416002

Page 15 of 15

Attachment 2c: Chronic Results File (Drinking Water Only)

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for FENOXAPROP-P-ETHYL NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\dwilbur\My Documents\DEEM 

Files\FPE\FPE_chronic_wateronly.r08

 Adjustment factor #2 used.

Analysis Date 11-12-2013/08:01:32 Residue file dated: 11-12-2013/08:01:07

Reference dose (RfD, Chronic) = .015 mg/kg bw/day

COMMENT 1: FPE chronic tolerance 100%CT cPAD=0.015

WATER ONLY

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.001436 9.6%

Hispanic 0.001371 9.1%

Non-Hisp-White 0.001477 9.8%

Non-Hisp-Black 0.001185 7.9%

Non-Hisp-Other 0.001656 11.0%

Nursing Infants 0.001300 8.7%

Non-Nursing Infants 0.004778 31.9%

Female 13+ PREG 0.001353 9.0%

Children 1-6 0.001840 12.3%

Children 7-12 0.001198 8.0%

Male 13-19 0.000987 6.6%

Female 13-19/NP 0.001106 7.4%

Male 20+ 0.001338 8.9%

Female 20+/NP 0.001509 10.1%

Seniors 55+ 0.001389 9.3%

All Infants 0.003704 24.7%

Female 13-50 0.001429 9.5%

Children 1-2 0.002072 13.8%

Children 3-5 0.001746 11.6%

Children 6-12 0.001259 8.4%

Youth 13-19 0.001047 7.0%

Adults 20-49 0.001433 9.6%

Adults 50-99 0.001417 9.4%

Female 13-49 0.001428 9.5%

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