P.1 

OAR Box 1112 

Prepped by Ryan Dugan 

Document Number: 

2) ll-B-1 

Docket Number: 

A-83-22 

Printed 4/16/2008 9:12:05 AM Sheet 2 of 97 
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f pJStt ^ UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

& ^l^- f ° Office of Air Quality Planning and Standards ^ „, , 

% PR0^° Research Triangle Park, North Carolina 27711 A ^ <f"*£ 

December 20 , 1984 

MEMORANDUM 

SUBJECT: Correspondence Pertainin g to Lead Risk Assessment Program 

FROM: John H. Haines^<&-** /J> A

 ENVra o*SI $^*&W * 

Ambient Standards' Branch (MD-12) AGENCY 

TO: Docke t Number A-83-2 2 D&C ^ ^ ^ ''' 

CENTRAL DOCKET 

The attached letters were sent to the five experts to be e^^Wcr 

about dose-response curves for lead-induced hemoglobin decrements and 

possible adverse health effects of elevated erythrocyte protoporphyrin. 

Attachments 
P.3 

ARCONNE NATIONAL LABORATORY 

9700 SOUTU CAS S AVENUE, P-ARQONNE, IlliNois 60459 TdEpk^E 512/972-

December 13, 1984 

Dr. Paul Hammond 

University of Cincinnati 

Kettering Laboratory 

Cincinnati, OH 45267 

Dear Dr. Hammond: 

Thank you for agreeing to participate in this very important study 

concerning the possible health effects of lead on children. Your judgments 

are critically needed in order for the EPA to complete a probabilistic risk 

assessment of these effects. 

We (Dr. Tom Wallsten of the University of North Carolina and I) have 

scheduled meeting with you on Thursday, January 10 at 9 A.M. Our promise is 

to try to accomplish as much as possible in the morning so that little or no 

time will actually be required in the afternoon. We can afford to be a little 

flexible on this point because, as I mentioned in our phone conversation, we 

will obtain your "final" judgments at a later date. Finalizing your judgments 

should be a relatively straightforward and quick task if things go well in our 

initial session, which is our expectation. 

Regarding the session, two issues are very important: the literature 

on lead and its possible health effects and the process of making probabilistic judgments. The lead criteria document, particularly Chapter 12 and its 

references, is the primary source of information. However, any additional or 

new research findings that you feel are important should also be considered to 

some degree as you make your judgments. The process of obtaining/giving 

probabilistic judgments is addressed in the protocol which is enclosed. 

However, the actual mechanics of the process is better explained in person, 

and Tom and I will do that with you at the beginning of the first session. 

If you sense the need to do so, feel free to review the lead literature 

before (or during!) our meeting. In addition, if there are any questions or 

concerns you have prior to the meeting, please contact either me or Tom 

Wallsten. Tom's phone number is (919) 962-5085 and mine is (312) 972-8430. 

US. DEPARTMENT of ENERQY T k UNIVERSITY of ClniCAqo 
P.4 

' , D . 2 December 13, 1984 

Dr. Paul Hammond

 L 

Again, thank you for generously agreeing to participate in this 

important step in the EPA's risk assessment. Tom and I are very much looking 

forward to our meetings with you on these matters. 

Ronald G. Whitfield, Ph.D. 

Energy and Environmental Systems Division 

RGW:bf 

Enclosures 

cc: J. Cohen - EPA 

J. Haines- EPA 

J. Peerenboom 

T. Surles 

T. Wallsten 

T. Wolsko 
P.5 

ARGONNE NATIONAL LABORATORY 

9700 SOUTIH CASS AVENUE, ARQONNE, WiNOis 60459 TdEpk)NE 512/972-

December 13, 1984 

Dr. Julian Chisolm 

Baltimore City Hospital 

4940 Eastern Avenue 

Baltimore, MD 21224 

Dear Dr. Chisolm: 

Thank you for agreeing to participate in this very important study 

concerning the possible health effects of lead on children. Your judgments 

are critically needed in order for the EPA to complete a probabilistic risk 

assessment of these effects. 

We (Dr. Tom Wallsten of the University of North Carolina and I) have 

scheduled meeting with you on Friday, January 11 at 9 A.M. Our promise is to 

try to accomplish as much as possible in the morning so that little or no time 

will actually be required in the afternoon. We can afford to be a little 

flexible on this point because, as I mentioned in our phone conversation, we 

will obtain your "final" judgments at a later date. Finalizing your judgments 

should be a relatively straightforward and quick task if things go well in our 

initial session, which is our expectation. 

Regarding the session, two issues are very important: the literature 

on lead and its possible health effects and the process of making probabilistic judgments. The lead criteria document, particularly Chapter 12 and its 

references, is the primary source of information. However, any additional or 

new research findings that you feel are important should also be considered to 

some degree as you make your judgments. The process of obtaining/giving 

probabilistic judgments is addressed in the protocol which is enclosed. 

However, the actual mechanics of the process is better explained in person, 

and Tom and I will do that with you at the beginning of the first session. 

If you sense the need to do so, feel free to review the lead literature 

before (or during!) our meeting. In addition, if there are any questions or 

concerns you have prior to the meeting, please contact either me or Tom 

Wallsten. Tom's phone number is (919) 962-5085 and mine is (312) 972-8430. 

US. DEPARTMENT of ENERqy T k UNIVERSITY of O-HCAQO 
P.6 

Dr. Julian Chisolm 2 December 13, 1984 

Again, thank you for generously agreeing to participate in this 

important step in the EPA's risk assessment. Tom and I are very much looking 

forward to our meetings with you on these matters. 

Sincerely, 

KMJW^ 

Ronald G. vfoitfield, Ph.D. 

Energy and Environmental Systems Division 

RGW:bf 

Enclosures 

cc: J. Cohen - EPA 

J. Haines- EPA 

J. Peerenboom 

T. Surles 

T. Wallsten 

T. Wolsko 
P.7 

ARGONNE NATIONAL LABORATORY 

9700 SOUTIH CASS AVENUE, ARQONNE, IlliNois 60459 

November 27, 1984 

Dr. John Rosen 

Head, Division of Pediatric Metabolism 

Montefiore Hospital and Medical Center 

111 East 210 Street 

Bronx, NY 10467 

Dear Dr. Rosen: 

Thank you for agreeing to participate in this very important study 

concerning the possible health effects of lead on children. Your judgments 

are critically needed in order for the EPA to complete a probabilistic risk 

assessment of these effects. 

We (Dr. Tom Wallsten of the University of North Carolina and I) have 

tentatively scheduled meeting with you on Friday, December 21 at 9 A.M. Our 

promise is to try to accomplish as much as possible in the morning so that 

little or no time will actually be required in the afternoon. We can afford 

to be a little flexible on this point because, as I mentioned in my phone 

conversation with Marilyn today, we will obtain your "final" judgments at- a 

later date. Finalizing your judgments should be a relatively straightforward 

and quick task if things go well in our initial session, which is our 

expectation. 

Regarding the session, two issues are very important: the literature 

on lead and its possible health effects and the process of making probabilistic judgments. The lead criteria document, particularly Chapter 12 and its 

references, is the primary source of information. However, any additional or 

new research findings that you feel are important should also be considered to 

some degree as you make your judgments. The process of obtaining/giving 

probabilistic judgments is addressed in the protocol which is enclosed. 

However, the actual mechanics of the process is better explained in person, 

and Tom and I will do that with you at the beginning of the first session. 

If you sense the need to do so, feel free to review the lead literature 

before (or during!) our meeting. In addition, if there are any questions or 

concerns you have prior to the meeting, please contact either me or Tom 

Wallsten. Tom's phone number is (919) 962-5085 and mine is (312)972-8430. 

U.S. DEPARTMENT of ENERQY T k UNivERSiTy of GHJCAQO 
P.8 

Dr. John Rosen 2 November 27, 1984 

Again, thank you for generously agreeing to participate in this 

important step in the EPA's risk assessment process. Tom and I are very much 

looking forward to our meeting with you on these matters. 

Sincerely, 

Ronald G. Whitfield, Ph.D. 

Energy and Environmental Systems Division 

RGW:bf 

Enclosures 

cc: J. Cohen - EPA 

J. Haines- EPA 

J. Peerenboom 

T. Surles 

T. Wallsten 

T. Wolsko 
P.9 

ARGONNE NATIONAL LABORATORY 

9700 SOUTIH CASS AVENUE, ARQONNE, Ulirois 60459 

November 20, 1984 

Dr. Sergio Piomelli 

Columbia University Medical School 

Division of Pediatric Hematology 

and Oncology 

New York, NY 10032 

Dear Dr. Piomelli: 

Thank you for agreeing to participate In this very important study 

concerning the possible health effects of lead on children. Your judgments 

are critically needed in order for the EPA to complete a probabilistic risk 

assessment of these effects. 

We (Dr. Tom Wallsten of the University of North Carolina and I) have 

tentatively scheduled meeting with you on Tuesday, December 18 from 1 P.M. to 

5 P.M. and Wednesday, December 19 from 9 A.M. to 12 P.M. Our promise Is to 

try to accomplish as much as possible in the Tuesday session so that little or 

no time will actually be required on Wednesday morning. We can afford to be a 

little flexible on this point because, as I mentioned in our phone conversation on November 6th, we will obtain your "final" judgments at a later 

date. Finalizing your judgments should be a relatively straightforward and 

quick task if things go well in our Initial session, which Is our expectation. 

Regarding the session, two issues are very important: the literature 

on lead and its possible health effects and the process of making probabilistic judgments. The lead criteria document, particularly Chapter 12 and its 

references, is the primary source of information. However, any additional or 

new research findings that you feel are important should also be considered to 

some degree as you make your judgments. The process of obtaining/giving 

probabilistic judgments Is addressed in the protocol which is enclosed. 

However, the actual mechanics of the process Is better explained In person, 

and Tom and I will do that with you at the beginning of the first session. 

If you sense the need to do so, feel free to review the lead literature 

before (or during!) our meeting. In addition, If there are any questions or 

concerns you have prior to the meeting, please contact either me or Tom 

Wallsten. Tom's phone number is (919) 962-5085 and mine Is (312) 972-8430. 

US DEPARTMENT of ENERqy T k UNivERSiTy of GHJCACJO 
P.10 

Dr. Sergio Piomelli 2 November 20, 1984 

** Again, thank you for generously agreeing to participate In this 

important step in the EPA's risk assessment. Tom and I are very much looking 

forward to our meetings with you on these matters. 

Sincerely, 

4^A^' 

Ronald G. Whitfield, Ph.D. 

Energy and Environmental Systems Division 

RGW:bf 

Enclosures 

cc: J. Cohen - EPA 

J. Haines- EPA 

J. Peerenboom 

T. Surles 

T. Wallsten 

T. Wolsko 
P.11 

ARCONNE NATIONAL LABORATORY 

9700 SOUTIH CASS AVENUE, ARQONNE, IlliNOis 60459 

November 20, 1984 

Dr. Bernard Davidow 

Assistant Commissioner 

New York City Department of Health 

455 First Avenue, Room 1273 

New York, NY 10016 

Dear Dr. Davidow: 

Thank you for agreeing to participate in this very important study 

concerning the possible health effects of lead on children. Your judgments 

are critically needed in order for the EPA to complete a probabilistic risk 

assessment of these effects. 

We (Dr. Tom Wallsten of the University of North Carolina and I) have 

tentatively scheduled meeting with you on- Wednesday, December 20 from 1 P.M. 

to 5 P.M. and Thursday, December 20 from 9 A.M. to 12 P.M. Our promise is to 

try to accomplish as much as possible in the Wednesday session so that little 

or no time will actually be required on Thursday morning. We can afford to be 

a little flexible on this point because, as I mentioned in our phone conversation on November 6th, we will obtain your "final" judgments at a later 

date. Finalizing your judgments should be a relatively straightforward and 

quick task if things go well in our initial session, which is our expectation. 

Regarding the session, two issues are very important: the literature 

on lead and its possible health effects and the process of making probabilistic judgments. The lead criteria document, particularly Chapter 12 and Its 

references, is the primary source of information. However, any additional or 

new research findings that you feel are important should also be considered to 

some degree as you make your judgments. The process of obtaining/giving 

probabilistic judgments is addressed In the protocol which is enclosed. 

However, the actual mechanics of the process is better explained in person, 

and Tom and I will do that with you at the beginning of the first session. 

If you sense the need to do so, feel free to review the lead literature 

before (or during!) our meeting. In addition, if there are any questions or 

concerns you have prior to the meeting, please contact either me or Tom 

Wallsten. Tom's phone number is (919) 962-5085 and mine is (312)972-8430. 

U.S. DEPARTMENT of ENERQY T k UNivERSiTy of GHJCAQO 
P.12 

Dr. Bernard Davidow 2 November 20, 1984 

Again, thank you for generously agreeing to participate in this 

important step in the EPA's risk assessment. Tom and I are very much looking 

forward to our meetings with you on these matters. 

Sincerely, 

faiMxfr^ 

Ronald G. Whitfield, Ph.D. 

Energy and Environmental Systems Division 

RGW:bf 

Enclosures 

cc: J. Cohen - EPA 

J. Haines- EPA 

J. Peerenboom 

T. Surles 

T. Wallsten 

T. Wolsko