**Exhibit      12.1**

**CERTIFICATION**

|   |  I,              Manuel Saba Ades, certify that: |
|--------|-------------------------------------------------------|
|   |                                                  |   |
|   | 1.                                               | I                have reviewed this annual report on Form 20-F of Grupo Casa Saba,                S.A. de                C.V. (the “Registrant”);  |
|   | 2.                                               | Based                on my knowledge, this annual report does not contain any untrue statement                of a material fact or omit to state a material fact necessary to                make the                statements made, in light of the circumstances under which such statements                were made, not misleading with respect to the period covered by this                annual report;  |
|   | 3.                                               | Based                on my knowledge, the financial statements, and other financial information                included in this annual report, fairly present in all material respects                the financial condition, results of operations and cash flows of                the                Registrant as of, and for, the periods presented in this annual                report;  |
|   | 4.                                               | The                Registrant’s other certifying officers and I are responsible for                establishing and maintaining disclosure controls and procedures (as                defined in Exchange Act Rules 13a-14 and 15d-14) for the Registrant                and we                have:  |
|   |                                                  | a)  | designed                such disclosure controls and procedures to ensure that material                information relating to the Registrant, including its consolidated                subsidiaries, is made known to us by others within those entities,                particularly during the period in which this annual report is being                prepared;  |
|   |                                                  | b)  | evaluated                the effectiveness of the Registrant’s disclosure controls and procedures                as of a date within 90 days prior to the filing date of this annual                report                (the “Evaluation Date”); and  |
|   |                                                  | c)  | presented                in this annual report our conclusions about the effectiveness of                the                disclosure controls and procedures based on our evaluation as of                the                Evaluation Date;  |
|   | 5.                                               | The                Registrant’s other certifying officers and I have disclosed, based on our                most recent evaluation, to the Registrant’s auditors and the audit                committee of Registrant’s board of directors (or persons performing the                equivalent function):  |
|   |                                                  | a)  | all                significant deficiencies in the design or operation of internal controls                which could adversely affect the Registrant’s ability to record, process,                summarize and report financial data and have identified for the                Registrant’s auditors any material weaknesses in internal controls;                and  |
|   |                                                  | b)  | any                fraud, whether or not material, that involves management or other                employees who have a significant role in the Registrant’s internal                controls; and  |
|   | 6.                                               | The                Registrant’s other certifying officers and I have indicated in this annual                report whether or not there were significant changes in internal                controls                or in other factors that could significantly affect internal controls                subsequent to the date of our most recent evaluation, including any                corrective actions with regard to significant deficiencies and material                weaknesses.  |

| Dated:                 June 30, 2006 | By:                 /s/                Manuel Saba AdesName:                Manuel Saba AdesTitle:                Chief Executive Officer |
|-------------------------------------------|------------------------------------------------------------------------------------------------------------------------------------------------|

----