### UNITED STATES ENVIRONMENTAL PROTECT I ON AGENCY WASHINGTON, D.C. 20460 OFF I CE OF CH E MICAL SAFETY AND POLLU TIO N PREVENTION



### MEMORANDUM Date: 14-November-2013 SUBJECT: Fenoxaprop-p-ethyl. Chronic Aggregate Dietary (Food and Dr inking Water) Exposure and Risk Assessment for Registration Review and a New Use on Grass Ha y. PC Code: 129092 Decision No.: 466648 , 4 7791 I DP Barcode: 0 415999 , 0416002 Registration N o . : 264-666 , 264

- 1 073 , 264- 653 Petition No.: 2£805 1 R eg ulatory Action: Sect i on 3 R egistratio n , Registration R eview Risk Assessment 

### Type: Dietary Case No.: NA TXR No.: NA CAS No.: 71283-80-2 MRID No.: NA 40 CFR: 180.430 

### FROM: Donald Wi l bur , Chemist

# ~**W~** Risk Assessment Bran ch V I H ealth Effects Division (HED , 7509P) TH ROUGH: Sheila Piper, Senior**Chern ~**  

### Seyed Tadayon,**Chemist ~** **~~P** 

### Dietary Exposure Science i sory Co uncil (DESAC) TO: Christopher Schlosser, Risk Assessor R egistration Branch V I Health Effects Division (7509 P ) Andrew Ertman! Barbara Madden , Risk Managers Risk Int egra tion Minor Use , and Emergency Respon se Branch Re gis tr a tion Division (7505 C) Molly Clayton, Chemical Review Manager Risk Management and Impl ementation Branch III Pesticide Re-evaluation Division (7508 P)

Page I of 15Fenoxaprop

- p - ethyl Dietary Exposure and Risk Assessment DP Number: D 415999 , D416002

Page 2 of 15 

### Executive Summary A chronic aggregate dietary food and drinking water exposure and risk assessment was conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM

- FCID) Version 3.16 . This software uses 2003

- 2008 food consumption data from the U.S. Department of Agriculture’s (USDA’s) National Health and Nut rition Examination Survey, What We Eat in America, (NHANES/WWEIA ). The analysis was conducted in support of a human

- health risk assessment for the proposed Section 3 use of fenoxaprop

- p - ethyl on grass hay as well as for the registration review process (D. Wilbur, D 415998 )
. This memorandum was reviewed by two peer reviewers o f the DE SAC per DESAC Standard Operating Procedure ( SOP ) 2012.1
. The un refined chronic analysis is based on tolerance

- level residues, 100% crop treated (%CT) assumptions , and DEEM default processing factors
. Using assumptions considered to be highly protective of human health, the chronic dietary risk estimates for food and water range from approximately 8. 9 % of the chronic population adjusted dose (cPAD ) for youths 13

- 19 to 27.5 % of the cPAD for all infants
. The general U.S. p opulation utilized 11.7 % of the cPAD. Generally, HED is concerned when dietary risk estimates exceed 100% of the PAD; therefore, the chronic dietary risk estimates for fenoxaprop

- p - ethyl are below HED’s leve l of concern (LOC) for all population subgroups, including those comprised of infants and children. No acute dietary exposure and risk analysis was performed since there were no appropriate studies that demonstrated evidence of toxicity attributable to a single dose for either the general population or for f

emales 13

- 49 years of age. Additionally, no cancer exposure and risk analysis was performed since quantification of r isk using a non

- linear approach ( i.e., RfD ) for FPE will adequately account for all chronic toxicity, including carcinogenicity, that could result from exposure to FPE. I. Introduction Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For chronic assessments , the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population

- adjusted dose (PAD). The PAD is equivalent to t he point of departure (POD, no observed adverse effect level ( NOAEL ) , lowest observed adverse effect level ( LOAEL ) , e.g.) divided by the required uncertainty or safety factors. For non

- cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References that discuss chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21

- JUN

- 2000, web link: http://www.epa. gov/fedrgstr/EPA

PEST/2000/July/Day

- 12/6061.pdf ; or see SOP 99.6 (20

- AUG

- 1999). This dietary assessment is being performed for a new use on grass grown for seed as well as for all registered uses to support registration review.Fenoxaprop

- p - ethyl Dietary Exposure and Risk Assessment DP Number: D 415999 , D416002

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### The last dietary assessment for FPE was conducted in 1998 in conjunction with a new use on barley. II. Residue Information Fenoxaprop

- p - ethyl [FPE; (+)

- ethyl 2

- [4

- [(6

- chloro

- 2

- benzoxazolyl)oxy]phenoxy]propanoate, PC Code 129092] is a selective aryloxyphenoxypropionate herbicide used to control grass weeds after emergence. FPE is currently registered for use on barley, co tton, rice, soybeans, and wheat. FPE is also registered for non

- agricultural use on conservation reserves, ornamentals, rights

- of

way, and turf. IR

- 4 is requesting a new tolerance be established on grass, hay to support a new use on grass grown for seed. A summary of the tolerances for FPE are shown below in Table 1.
Table 1 . Tolerance Summary for FPE Commodity Residue (ppm) Barley, grain 0.05 Barley, straw 0.1 Cattle, fat 0.05 Cattle, meat byproducts 0.05 Cattle, meat 0.05 Cotton, undelinted seed 0.05 Goat, fat 0.05 Goat, meat byproducts 0.05 Goat, meat 0.05 Hog, fat 0.05 Hog, meat byproducts 0.05 Hog, meat 0.05 Horse, fat 0.05 Horse, meat byproducts 0.05 Horse, meat 0.05 Milk 0.02 Peanut 0.05 Peanut, hulls 0.05 Rice, grain 0.05 Sheep, fat 0.05 Sheep, meat byproducts 0.05Fenoxaprop

- p - ethyl Dietary Exposure and Risk Assessment DP Number: D 415999 , D416002

Page 4 of 15 Sheep, meat 0.05 Soybean 0.05 Wheat, grain 0.05 Wheat, straw 0.50 Section 18 emergency exemptions Grass, forage 0.05 ppm (expires 12/31/13) Grass, hay 0.05 ppm (expires 12/31/13) 

### The residue (s) of concern for both the tolerance expression and risk assessm ent in plants and animals is fenoxaprop

- ethyl, (±)

- ethyl 2

- [4

- [(6

- chloro

- 2

- benzoxazolyl)oxy]phenoxy]propanoate, and its metabolites, 2

- [4

- [(6

- chloro

- 2

- benzoxazolyl)oxy]phenoxy]propanoic acid and 6

- chloro

2,3

- dihydrobenzoxazol

- 2

- one, calculated as the stoichiometric equivalent of fenoxaprop

- ethyl . It is importan t to note that while the tolerance is in terms of fenoxaprop

- ethyl (a 50:50 racemic mixture of d and l enantiomers), it is protective for all uses of fenoxaprop

- p - ethyl (95% d and 5% l enantiomers) since both the data

- collection and enforcement methods are not stereospecific and cannot determine the different between the two compounds. The chronic dietary exposure and risk estimates are considered un refined since they assume tolerance levels, 100 % CT, and use DEEM TM default processing factors
. The USDA Pes ticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009, and 2010. Over this 3

- year period, PDP analyzed 1479 samples of catfish for fenoxaprop

- p - ethyl residues. None of the samples contained detectable residues. As a result, res idues in fish were not included in the assessment. I I I. Percent Crop Treated Information The chronic analysis was performed assuming 100% of each crop was treated with fenoxaprop

p - ethyl ( i.e., 100% CT). IV. Drinking Water Data A screening

- level drinking water assessment (DWA) for fenoxaprop

- p - ethyl was conducted in support of registration review and the IR

- 4 petition 2E8051 for use on grass grown for seed (C. Peck, D411291, D404234, 09/25/2013) . Fenoxaprop

- p - ethyl [FPE; (+)

- ethyl 2

- [4

- [(6

- chloro

- 2

- benzoxazolyl)oxy]phenoxy]propanoate, PC Code 129092] is a selective aryloxyphenoxypropionate herbicide used to control grass weeds after emergence. FPE is currently registered for use on barley, cotton, rice, soybeans, and wheat, and is registered for non - agricultural use on conservation reserves, ornamentals, rights

- of

- way, and turf. This assessment is based on available environmental fate data. There are no significant data gaps in the environmental fate database. There are no existing monitoring d ata for FPE or its degradates. The maximum application rate for the foliar uses is for ornamentals, rights

- of

- way, and turf, at 0.173 lbs a.i./acre/application, applied with a 14

- day reapplication interval and a maximum total annual application rate of 0. 531 lb a.i./A/yr. The maximum proposed application rate for theFenoxaprop

- p - ethyl Dietary Exposure and Risk Assessment DP Number: D 415999 , D416002

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### proposed new grass grown for seed use is 0.083 lbs a.i./acre/application, applied one time per year for a maximum total annual application rate of 0.083 lb a.i./A/yr. Use on rice was also ev aluated, as managed aquatic releases from rice paddies impact receiving water hydrology and chemistry differently than rainfall

- driven runoff from more

- typical agricultural land. The maximum proposed application rate for rice use is 0.108 lbs a.i./A/appli cation, applied twice per year with a 14

- day reapplication interval, with a maximum total annual application rate of 0.188 lb a.i./A/yr. FPE is partially soluble in water, dissolving at 0.7 mg/L at 20°C and pH 5.8. FPE residues are considered moderately mobile. The compound is not expected to volatilize significantly due to its low vapor pressure of 1.4 x 10 - 8 

### torr (20°C) . The octanol

- water partition coefficient of FPE is 38,000, with a relatively high bioconcentration factor (BCF) observed in fish visce ra (1021x) compared to the edible fi sh portions (129x) . The BCF for whole fish portions was 510x, which does not exceed reporting thresholds fo r concern for bioconcentration
. FPE is hydrolyzed moderately rapidly in acidic conditions (t 1⁄2 

### = 19.6 d at pH 5) and neutral conditions (t 1⁄2 

### = 24.6 d at pH 7), and quickly in alkaline conditions (t 1⁄2 

### = 0.7 d at pH 9 ) . Two major hydrolytic degradates were identified: fenoxaprop

- p acid (AE F088406) and chlorobenzoxazolone (AE F054014). Both FPE and fenoxaprop

- p acid may hydrolyze to chlorobenzoxazolone, which was observed in the hydrolysis study at up to 64% of the ap plied at pH 5(30 DAT), 23% of the applied at pH 7 (30 DAT), and 20% of the applied at pH 9 (30 DAT). When considering the combined residues however, they were stable to hydrolysis at all pHs. FPE also degrades quickly via aqueous photolysis, with an esti mated half

- life of 0.95 day s . FPE was quickly biodegraded in aerobic soils (t 1⁄2 

### ≤ 1.63 d), in aerobic aquatic systems ( t 1⁄2 

### < 1 d ) and in anaerobic aquatic systems (t 1⁄2 

### ≤ 2.4 d). The computer models PRZM and EXAMS and the Tier I Rice model were used to gen erate surface water EDWCs for use in the human health dietary risk assessment, while the PRZM

- GW and SCI

- GROW models were used to generate groundwater EDWCs. In 2007, the Health Effects Division (HED) identified FPE and its two degradates, fenoxaprop

- p ac id ((D+)

- 2

- [4

- (6

- chloro

- 2

- benzoxazolyloxy) phenoxy] propanoate, AE F088406) and chlorobenzoxazolone (4

- (6

- chloro

- 2

- benzoxazolyloxy) phenol, AE F054014), as residues of concern in drinking water because these residues retained the 6

- chloro

- 2

- benzoxazol moie ty. Newly submitted environmental fate studies indicated that a fourth degradate, 4

- (6

- chloro

- 2

- benzoxazolyloxy) phenol (AE F040356), also contained the 6

- chloro

- 2

- benzoxazol moiety. This degradate was included as a residue of concern, so the parent plus the three degradates were assessed using a total toxic residue (TTR) approach. Additionally, as high levels ( e.g. , >20%) of non

- extracted residues (NER) were found in all environmental fate studies and these NER were found to contain levels of two degrad ates of concern (fenoxaprop

- p acid and chlorobenzoxazolone) when subjected to harsh mineral acid extraction, NER were also included in the TTR approach. However, it is uncertain as to how available these residues are to reaching surface water and groundwa ter drinking water sources. As such, EFED modeled FPE TTR with and without NER to bracket the EDWCs. Descriptions of the models are available at the EPA internet site: http://www.epa.gov/oppefed1/mo dels/water/
.Fenoxaprop

- p - ethyl Dietary Exposure and Risk Assessment DP Number: D 415999 , D416002

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### The maximum acute and chronic surface EDWCs ( 110 and 69 μ g/L , respectively) were associated with application to rice. Surface water EDWCs for the proposed new use of grass grown for seed were much lower than the maximum values (acute EDWC of 1.65 μ g/L and a chronic EDWC of 0.62 μ g/L). For groundwater sources of drinking water, the maximum acute and chronic estimated concentrations of FPE TTR in shallow groundwater from PRZM

- GW for applications to turf were 0.17 and 0.032 μg/L , respectively. The maximum groundwater EDWC reported from SCI

- GROW was 0.096 μ g/L for the chemical’s use on turf. Maximum EDWCs for FPE residues in surface water and groundwater recommended for dietary assessment are presented in Table 2. Water residue s were incorporated in the DEEM

- FCID into the food categories “water, direct, all sources” and “water, indirect, all sources.” Table 2 . Maximum EDWCs of FPE ( plus toxic degradates ) DRINKING WATER SOURCE (MODEL USED) USE (rate modeled) MAXIMUM ESTIMATED DRINKING WATER CONCENTRATION (EDWC)

( ppb) 1 - in - 10 year acute ( μg/L ) 1 - in - 10 year

chronic ( μg/L )
Surface water (Tier I Rice Model) Foliar Rice

(first app at 0.108 lbs a.i./A, 14 day RTI, second app at 0.034 lbs a.i./A, third app at 0.046 lbs a.i./A) 110 68.6

Groundwater (PRZM

- GW) Aerial Foliar

(turf, 0.173 lbs a.i./A x 3, RTI = 14 days, fourth app at 0.012 lbs a.i./A) 0.17 0.032

V. DEEM - FCID Program and Consumption Information The fenoxaprop

- p - ethyl chro nic dietary exposure assessment was conducted using the DEEM

FCID, Version 3.16 , which incorporates 2003

- 2008 consumption data from USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 individuals over two non

- consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA

- defined food commodities (e.g. , apples, peeled fruit

- cooked; fresh or N/S; baked; or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups
. Based on analysis of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50

- 99 year s old.Fenoxaprop

- p - ethyl Dietary Exposure and Risk Assessment DP Number: D 415999 , D416002

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### For a chronic dietary exposure assessment, an estimate of the residue level in each food or food

form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup. VI. Toxicological Information Fenoxaprop

- ethyl (HOE 033171; FE) was first registered as a racemic mixture of D/L isom ers. Since registration, the more biologically active isomer D+, fenoxaprop

- p - ethyl (HOE 046360; FPE) has been registered. ToxSAC/HASPOC found that the toxicological effects of FE and FPE across species, duration, and route of exposure are remarkably sim ilar. It was, therefore, concluded that the similarity between the FE and FPE data was such that the database for FE could be bridged with FPE. FPE has low acute toxicity following the oral, dermal, and inhalation routes of exposure. No evidence of repro ductive or neurological toxicity was identified in the database. The major target organs following short

- term and long

- term oral administration of FE and FPE in rats and mice are the liver and kidneys, with rats being the most sensitive species. The prima ry toxic effect is altered lipid metabolism characterized by decreased lipids and cholesterol, and increased liver weights in rats and slightly increased lipids, cholesterol and proteins and increases liver weights in mice. In mice, a treatment

- related in crease in tumor incidence of hepatocellular adenomas and carcinomas, mainly adenomas, was observed in males. There was, however, no evidence of a mutagenic effect in a comprehensive battery of genetic toxicology assays with both isomers. In accordance wi th EPA’s Final Guidelines for Carcinogen Risk Assessment (2005), CARC classified FE/FPE as “Suggestive Evidence of Carcinogenic Potential”. No evidence of tumors was identified in rats An acute reference dose has not been established for either the gene ral population or for females 13

- 49 years of age since there were no appropriate studies that demonstrated evidence of toxicity attributable to a single dose for these populations. For chronic dietary exposure and risk assessment, the chronic/carcinogenic ity and 2

- generation reproductive toxicity studies in rats, conducted on the FE, were selected with a NOAEL of 1.5 mg/kg/day identified in both studies. The LOAEL is 9 mg/kg/day based on decreased serum lipids and cholesterol, and changes in liver weights in both studies, as well as increased ALP and liver weights in pups from the 2

- generation reproductive toxicity study. The FQPA factor may be reduced to 1X based on adequate toxicity database and exposure data. There is no evidence of susceptibility/sensitivity and there are no residual uncertainties concerning pre

- or post
- natal toxicity. No evidence of neurotoxicity was identified throughout the database for FE or FPE. All endpoints used in this risk assessment are protective of devel opmental effects in FE and FPE.Fenoxaprop

- p - ethyl Dietary Exposure and Risk Assessment DP Number: D 415999 , D416002

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### A summary of the toxicological doses and endpoints for FPE for use in dietary exposure ass essments is presented in Table 3
. Table 3 . Toxicological Doses and Endpoints for FPE for Use in Dietary Health Risk Assessments Exposure/ Scenario Point of

Departure Uncertainty/

FQPA Safety Factors RfD/PAD,

Level of Concern for Risk Assessment Study and Toxicological Effects Acute Dietary (General Population) No appropriate endpoint attributable to a single dose was identified. An acute RfD was

not established. Acute Dietary (Females 13

- 49 years of age)

Chronic Dietary (All Populations) NOAEL = 1.5

mg/kg/day UF A 10x

UF H 10x FQPA SF = 1X Chronic RfD

= 0.015 mg/kg/day
cPAD = 0.015 mg/kg/day Chronic Toxicity/Carcinogenicity (rat)

MRIDs: 00149664, 0149665, 00151564, 00151565 2

- Generation Reproductive Toxicity

(rat) MRID: 00159920 LOAEL = 9 mg/kg/day, based on decreased serum lipids and cholesterol, and altered liver weights Cancer (oral) Classification: "Suggestive evidence of carcinogenic potential"; quantification of risk

using a non

- linear approach; i.e., RfD, for FPE will adequately account for all chronic toxicity, including carcinogenicity, that could result from exposure to FPE. Point of Departure (POD) = A data point or an estimated point derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed ad verse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animals to humans (interspecies). UF H = potential variation in sensitivity among members of the human population (intraspecies). FQPA S F = FQPA Safety Factor. cPAD = chronic population adjusted dose. RfD = reference dose. N/A = not applicable. 

### VII. Results/Discussion As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% of the c PAD. The DEEM

- FCI D analyses estimate the dietary exposure and risk of the U.S. population and various population subgroups. The results reported in Table 4 (a

- c) below are for the general U.S. Population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12 , youth 13

- 19, females 13

- 49, adults 20

- 49, and adults 50

- 99 years. C ombined chronic dietary exposure estimates for food and drinking water are below HED’s level of concern for all population subgroups, including those of infants and children . The most highly exposed population subgroup is all infants at 27.5 % of the cPAD, while the gener al U.S. population utilized 11.7 % of the cPAD.Fenoxaprop

- p - ethyl Dietary Exposure and Risk Assessment DP Number: D 415999 , D416002

Page 9 of 15 Table 4 a . Summary of Estimated Dietary (Food + Drinking Water) Exposures and Risk for Fenoxaprop - p - ethy l Population Subgroup cPAD, mg/kg/day Chronic Estimates

Exposure, mg/kg/day Risk, % cPAD U.S. Population

0. 015 0. 00 1757 11.7 All infants (< 1 year) 0. 00 4121 27.5 Children 1

- 2 yrs 0. 003 361 22.4 Children 3

- 5 yrs 0. 002 634 17.6 Children 6

- 12 yrs 0. 001 810 1 2.1 Youth 13

- 19 yrs 0. 001 340 8.9 Adults 20

- 49 yrs 0. 001 671 1 1.1 Adults 50

- 99 yrs 0. 001 617 10. 8 Females 13

- 49 yrs 0. 001 646 1 1.0 *The subpopulation (s) with the highest risk estimates are bolded
. Table 4 b . Summary of Estimated Dietary (Food Only ) Exposures and Risk for Fenoxaprop - p - ethyl Population Subgroup cPAD, mg/kg/day Chronic Estimates

Exposure, mg/kg/day Risk, % cPAD U.S. Population

0.015 0.000321 2.1 All infants (< 1 year) 0.000417 2.8 Children 1 - 2 yrs 0.001288 8.6 Children 3

- 5 yrs 0.000888 5.9 Children 6

- 12 yrs 0.000551 3.7 Youth 13

- 19 yrs 0.000292 1.9 Adults 20

- 49 yrs 0.000238 1.6 Adults 50

- 99 yrs 0.000200 1.3 Females 13

- 49 yrs 0.000218 1.5 *The subpopulation(s) with the highest risk estimates are bolded
. Table 4 c . Summary of Estimated Dietary (Drinking Water Only ) Exposures and Risk for Fenoxaprop - p - ethyl Population Subgroup cPAD, mg/kg/day Chronic Estimates

Exposure, mg/kg/day Risk, % cPAD U.S. Population

0.015 0.001436 9.9 All infants (< 1 year) 0.003704 24.7 Children 1

- 2 yrs 0.002072 13.8 Children 3

- 5 yrs 0.001746 11.6 Children 6

- 12 yrs 0.001259 8.4 Youth 13

- 19 yrs 0.001047 7.0 Adults 20

- 49 yrs 0.001433 9.6 Adults 50

- 99 yrs 0.001417 9.4 Females 13

- 49 yrs 0.001428 9.5 *The subpopulation(s) with the highest risk estimates bolded
.Fenoxaprop

- p - ethyl Dietary Exposure and Risk Assessment DP Number: D 415999 , D416002

Page 10 of 15 

### VIII. Characterization of Inputs/Outputs This chronic dietary exposure and risk analysis is based on tolerance

- level residues, 100% crop treated assumptions, and default processing factors. As the exposure estimates to all population subgroups are below HED’s level of concern, it was no t necessary to make refinements. If it had been necessary to refine the analys is, field trial residue values could have been used in place of tolerance level residues and percent crop treated could have been incorporated. IX. Conclusions This un refine d analysis demonstrates that the existing and proposed use of fenoxaprop

- p - ethyl will not result in chronic dietary risk estimates (food plus drinking water) that exceed HED’s level of concern for any of the regulated populated subgroups, including those comprised of infants and children. HED is confident that the assessment does n ot underestimate risk to the general U.S. population or any population subgroup. There are no dietary risk considerations relating to the proposed or existing uses of fenoxaprop

- p - ethyl.Fenoxaprop

- p - ethyl Dietary Exposure and Risk Assessment DP Number: D 415999 , D416002

Page 11 of 15 

### X. List of Attachments

• Chronic Residue Input F ile

• Chronic Results File s
Attachment 1 : Chronic Food plus Water Residue Input File US EPA Ver. 3.16, 03
- 08
- d DEEM
- FCID Chronic analysis for FENOXAPROP
- P
- ETHYL Residue file: C: \ Documents and Settings \ dwilbur \ My Documents \ DEEM Files \ FPE \ FPE_chronic.r08 Adjust. #2 used Analysis Date 11
- 06
- 2013 Residue file dated: 11
- 06
- 2013/08:22:34 Reference dose (RfD) = 0.015 mg/kg bw/day Comment:FPE chronic tolerance 100%CT cPAD=0.015

---------------------------------------------------------------------------------- Food Crop Residue Adj.Factors EPA Code Grp Food Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ 1500025000 15 Barley, pearled barley 0.050000 1.000 1.000 1500025001 15 Barley, pearled barley
- babyfood 0.050000 1.000 1.00 0 1500026000 15 Barley, flour 0.050000 1.000 1.000 1500026001 15 Barley, flour
- babyfood 0.050000 1.000 1.000 1500027000 15 Barley, bran 0.050000 1.000 1.000 31000 44000 31 Beef, meat 0.050000 1.000 1.000 3100044001 31 Beef, meat
- babyfood 0.050000 1.000 1.000 3100045000 31 Beef, meat, dried 0.050000 1.920 1.000 3100046000 31 Beef, meat byproducts 0.050000 1.000 1.000 3100046001 31 Beef, meat byproducts
- babyfood 0.050000 1.000 1.000 3100047000 31 Beef, fat 0.050000 1.000 1.000 3100047001 31 Beef, fat
- babyfood 0.050000 1.000 1.000 3100048000 31 Beef, kidney 0.050000 1.000 1.000 3100049000 31 Beef, liver 0.050000 1.000 1.000 3100049001 31 Beef, liver
- babyfoo d 0.050000 1.000 1.000 2003128000 20C Cottonseed, oil 0.050000 1.000 1.000 2003128001 20C Cottonseed, oil
- babyfood 0.050000 1.000 1.000 3200169000 32 Goat, meat 0.050000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.050000 1.000 1.000 3200171000 32 Goat, fat 0.050000 1.000 1.000 3200172000 32 Goat, kidney 0.05 0000 1.000 1.000 3200173000 32 Goat, liver 0.050000 1.000 1.000 3300189000 33 Horse, meat 0.050000 1.000 1.000 3600222000 36 Milk, fat 0.020000 1.000 1.000 3600222001 36 Milk, fat
- baby food/infant formu 0.020000 1.000 1.000 3600223000 36 Milk, nonfat solids 0.020000 1.000 1.000 3600223001 36 Milk, nonfat solids
- baby food/in 0.020000 1.000 1.000 3600224000 36 Milk, water 0.020000 1.000 1.000 3600224001 36 Milk, water
- babyfood/infant form 0.020000 1.000 1.000 3600225001 36 Milk , sugar (lactose)
- baby food/ 0.020000 1.000 1.000 9500263000 O Peanut 0.050000 1.000 1.000 9500264000 O Peanut, butter 0.050000 1.890 1.000 9500265000 O Peanut, oil 0.050000 1.000 1.000 3400290000 34 Pork, meat 0.050000 1.000 1.000 3400290001 34 Pork, meat
- babyfood 0.050000 1.000 1.000 3400291000 34 Pork, skin 0.050000 1.000 1.000 3400292000 34 Pork, meat byproducts 0.050000 1.000 1.000 3400292001 34 Pork, meat byproducts
- babyfood 0.050000 1.000 1.000 3400293000 34 Pork, fat 0.050000 1.000 1.000 3400293001 34 Pork, fat
- babyfood 0.050000 1.000 1.000Fenoxaprop

- p - ethyl Dietary Exposure and Risk Assessment DP Number: D 415999 , D416002

Page 12 of 15 3400294000 34 Pork, kidney 0.050000 1.000 1.000 3400295000 34 Pork, liver 0.050000 1.000 1.000 1500323000 15 Rice, white 0.050000 1.000 1.000 1500323001 15 Rice, white
- babyfood 0.050000 1.000 1.000 1500324000 15 Rice, brown 0.050000 1.000 1.000 1500324001 15 Rice, brown
- babyfood 0.050000 1.000 1.000 1500325000 15 Rice, flour 0.050000 1.000 1.000 1500325001 15 Rice, flour
- babyfood 0.050000 1.000 1.000 1500326000 15 Rice, bran 0.050000 1.000 1.000 1500326001 15 Rice, bran
- babyfood 0.050000 1.000 1.000 3500339000 35 Sheep, meat 0.050000 1.000 1.000 35003390 01 35 Sheep, meat
- babyfood 0.050000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.050000 1.000 1.000 3500341000 35 Sheep, fat 0.050000 1.000 1.000 3500341001 35 Sheep, fat
- babyfood 0.050000 1.000 1.000 3500342000 35 Sheep, kidney 0.050000 1.000 1.000 3500343000 35 Sheep, liver 0.050000 1.000 1.000 0600347000 6 Soybean, s eed 0.050000 1.000 1.000 0603348000 6C Soybean, flour 0.050000 1.000 1.000 0603348001 6C Soybean, flour
- babyfood 0.050000 1.000 1.000 0600349000 6 Soybean, soy milk 0.050000 1.000 1.000 0600349001 6 Soybean, soy milk
- babyfood or in 0.050000 1.000 1.000 0600350000 6 Soybean, oil 0.050000 1.000 1.000 0600350001 6 Soybean, oil
- babyfood 0.050000 1.000 1.000 1500381000 15 Triticale, flour 0.050000 1.000 1.000 1500381001 15 Triticale, flour
- babyfood 0.050000 1.000 1.000 8601000000 86A Water, direct, all sources 0.068 600 1.000 1.000 8602000000 86B Water, indirect, all sources 0.068600 1.000 1.000 1500401000 15 Wheat, grain 0.050000 1.000 1.000 1500401001 15 Wheat, grain
- babyfood 0.050000 1.00 0 1.000 1500402000 15 Wheat, flour 0.050000 1.000 1.000 1500402001 15 Wheat, flour
- babyfood 0.050000 1.000 1.000 1500403000 15 Wheat, germ 0.050000 1.000 1.0 00 1500404000 15 Wheat, bran 0.050000 1.000 1.000 0601349500 6AB Soybean, vegetable 0.050000 1.000 1.000Fenoxaprop

- p - ethyl Dietary Exposure and Risk Assessment DP Number: D 415999 , D416002

Page 13 of 15 

### Attachment 2 a : Chronic Results File (Food and Drinking Water)
US EPA Ver. 3.16, 03
- 08
- d DEEM
- FCID Chronic analysis for FENOXAPROP
- P
- ETHYL NHANES 2003
- 2008 2
- day Residue file name: C: \ Documents and Settings \ dwilbur \ My Documents \ DEEM Files \ FPE \ FPE_chronic.r08 Adjustment factor #2 used. Analysis Date 11
- 06
- 2013/08:24:09 Residue file dated: 11

- 06
- 2013/08:22:34 Reference dose (RfD, Chronic) = .015 mg/kg bw/day COMMENT 1: FPE chronic tolerance 100%CT cPAD=0.015

============ =================================================================== Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

------- ------------------------------- ------------- ---------------- Total US Population 0.001757 11.7% Hispanic 0.001736 11.6% Non
- Hisp
- White 0.001793 12.0% Non
- Hisp
- Black 0.001464 9.8% Non
- Hisp
- Other 0.002021 13.5% Nursing Infants 0.001460 9.7% Non
- Nursing Infants 0.005309 35.4% Female 13+ PREG 0.001610 10.7% Children 1
- 6 0.002849 19.0% Children 7
- 12 0.001711 11.4% Male 13
- 19 0.001317 8.8% Female 13
- 19/NP 0.001363 9.1% Male 20+ 0.001585 10.6% Female 20+/NP 0.001707 11.4% Seniors 55+ 0.001587 10.6% All Infants 0.004121 27.5% Female 13
- 50 0.001647 11.0% Children 1
- 2 0.003361 22.4% Children 3
- 5 0.002634 17.6% Children 6
- 12 0.001810 12.1% Youth 13
- 19 0.001340 8.9% Adults 20
- 49 0.001671 11.1% Adults 50
- 99 0.001617 10.8% Female 13
- 49 0.001646 11.0%Fenoxaprop

- p - ethyl Dietary Exposure and Risk Assessment DP Number: D 415999 , D416002

Page 14 of 15 

### Attachment 2b : Chronic Results File (Food Only) US EPA Ver. 3.16, 03
- 08
- d DEEM
- FCID Chronic analysis for FENOXAPROP
- P
- ETHYL NHANES 2003
- 2008 2
- day Residue file name: C: \ Documents and Settings \ dwilbur \ My Documents \ DEEM Files \ FPE \ FPE_chronic_foodonly.r08 Adjustment factor #2 used. Analysis Date 11
- 12
- 2013/07:56:33 Residue file dated: 11

- 12
- 2013/07:56:02 Reference dose (RfD, Chronic) = .015 mg/kg bw/day COMMENT 1: FPE chronic tolerance 100%CT cPAD=0.015 FOOD ONLY

=============================================================================== Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

--------- -------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- -------------- -- Total US Population 0.000321 2.1% Hispanic 0.000365 2.4% Non
- Hisp
- White 0.000316 2.1% Non
- Hisp
- Black 0.000279 1.9% Non
- Hisp
- Other 0.000366 2.4% Nursing Infants 0.000161 1.1% Non
- Nursing Infants 0.000531 3.5% Female 13+ PREG 0.000258 1.7% Children 1
- 6 0.001010 6.7% Children 7
- 12 0.000514 3.4% Male 13
- 19 0.000330 2.2% Female 13
- 19/NP 0.000256 1.7% Male 20+ 0.000247 1.6% Female 20+/NP 0.000198 1.3% Seniors 55+ 0.000198 1.3% All Infants 0.000417 2.8% Female 13
- 50 0.000217 1.4% Children 1
- 2 0.001288 8.6% Children 3
- 5 0.000888 5.9% Children 6
- 12 0.000551 3.7% Youth 13
- 19 0.000292 1.9% Adults 20
- 49 0.000238 1.6% Adults 50
- 99 0.000200 1.3% Female 13
- 49 0.000218 1.5%

------------ -------------------------------------------------------------------Fenoxaprop

- p - ethyl Dietary Exposure and Risk Assessment DP Number: D 415999 , D416002

Page 15 of 15 

### Attachment 2c : Chronic Results File (Drinking Water Only) US EPA Ver. 3.16, 03
- 08
- d DEEM
- FCID Chronic analysis for FENOXAPROP
- P
- ETHYL NHANES 2003
- 2008 2
- day Residue file name: C: \ Documents and Settings \ dwilbur \ My Documents \ DEEM Files \ FPE \ FPE_chronic_wateronly.r08 Adjustment factor #2 used. Analysis Date 11
- 12
- 2013/08:01:32 Residue file dated: 11

- 12
- 2013/08:01:07 Reference dose (RfD, Chronic) = .015 mg/kg bw/day COMMENT 1: FPE chronic tolerance 100%CT cPAD=0.015 WATER ONLY

=============================================================================== Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

--------- -------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- -------------- -- Total US Population 0.001436 9.6% Hispanic 0.001371 9.1% Non
- Hisp
- White 0.001477 9.8% Non
- Hisp
- Black 0.001185 7.9% Non
- Hisp
- Other 0.001656 11.0% Nursing Infants 0.001300 8.7% Non
- Nursing Infants 0.004778 31.9% Female 13+ PREG 0.001353 9.0% Children 1
- 6 0.001840 12.3% Children 7
- 12 0.001198 8.0% Male 13
- 19 0.000987 6.6% Female 13
- 19/NP 0.001106 7.4% Male 20+ 0.001338 8.9% Female 20+/NP 0.001509 10.1% Seniors 55+ 0.001389 9.3% All Infants 0.003704 24.7% Female 13
- 50 0.001429 9.5% Children 1
- 2 0.002072 13.8% Children 3
- 5 0.001746 11.6% Children 6
- 12 0.001259 8.4% Youth 13
- 19 0.001047 7.0% Adults 20
- 49 0.001433 9.6% Adults 50
- 99 0.001417 9.4% Female 13
- 49 0.001428 9.5%

------------ -------------------------------------------------------------------