UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHfNGTON, D.C. 20460 

OFFICE OF CEMICAL SAFETY AND 

POLLUTION PREVENTION 

PC Code: 080302 

DP Barcode: 421927 

April 15, 2015 

MEMORANDUM 

SUB.JECT: Ecological Risk Assessment for Proposed Section 3 New Uses for Fluopyram on 

Artichoke, Vegetables (Brassica. bulb, cucurbits, fruiting, leafy, legumes and 

root/tuberous/corm), Carrot, Cereal grains, Citrus, Cotton, Ginseng, Grapes, 

Small vines fruits, grasses (forage/feed/seed), Herbs, Hops, Soybean, Oil seed 

group, Ornamentals, Peanut, Pome fruits, Potato, Small berri es, Stone fruit, 

Strawberry and other low-growing berries, Sugarbeet, Tree nuts and Turf 

TO: 

FROM: 

Driss Benmhend, Risk Manager Reviewer 

Shaja Joyner, Risk Manager 20 

Fungicide Branch 

Registration Division (PRO) (7505P) 

Geoffrey Sinclair, Ph.D., Biologist ~ r-... 

Mohammed Ruhman, Ph.D., Senior Agronomist J~~==~ ff--Z \>S;~~~~ ....... 

Environmental Risk Branch v o4/ IS) IS 

Environmental Fate and Effects Division (7507P) 'f/ !S/!S" 

THROUGH: Mah Shamim, Ph.D., Bra nch Chief 

Environmental Risk Branch VI 

Environmental Fate and Effects Division (7507P) 

This memo contains the findings of a Section 3 New Use Ecological Risk Assessment for eleven 

new or amended labels that cover seed treatment for cotton, soybean and peanuts, and soil/foliar 

applications by ground/air/air blast/chemigation for many crops and foliar/drench applications by 

ground/chemigation for turf and ornamentals. The eleven new or amended labels are for products 

with formulations containing fl uopyram alone and fonnulations containing fluopyram with other 

active ingredients. Fluopyram is a fungicide and current formulations for fluopyram include 

suspension concentrates for the chemical alone (4 1.5% a.i), or with other fungicides including 

tebuconazole, trifloxystrobin, pyrimethanil, or prothioco nazole. Fluopyram and /or its mixtures 

have agricultural uses on apples, watermelons, selected dry beans, grapes (wine), peanuts, 

potatoes, strawberries, sugar beet, and tree nuts applied by ground, air blast, and aerial spray into 

foliage and seed treatments for cotton, soybean and peanuts. f'luopyran1 is a fungicide to prevent 
2

and/or control fungal diseases. The biochemical mode of action of this chemical involves the 

inhibition of the enzyme succinate dehydrogenase within the fungal mitochondrial respiratory 

chain, thus blocking electron transport. Risk associated with the proposed new uses of 

fluopyram are confined primarily to terrestrial taxa. For spray applications there was chronic 

dietary based risk from consumption of all dietary categories but the fruit/pods/seeds category. 

Spray applications also resulted in chronic dosed-based risk to mammalian taxa in every size 

class for short grass for most dietary items for small and medium sized mammals. Exposure to 

Fluopyram via seed treatments potentially poses acute risk to small and medium sized 

endangered avian and mammalian species. There was chronic risk indicated for both avian and 

mammalian taxa from all seed treatments. 

I. Previous Use Patterns and Ecological Risk Assessments

Two ecological risk assessments were conducted previously. The first assessment was for a 

Section 3 new chemical registration of fluopyram (DP Barcode D353315, 369756, and 385637, 

dated 8/29/11). This assessment covered the following crops: Apples, Beans (dry), Cherries, 

Cucurbits, Grapes (wine), Peanut, Potato, Stone Fruits, Strawberry, Sugar beet, and Tree Nuts.

The second assessment (DP Barcode 414232 dated June 25, 2014) was for Fluopyram New Uses 

on cotton “in-furrow and seed treatment”, Soybeans “seed treatment” and Peanuts “in-furrow 

and foliar applications.

The results of the first assessment (DP Barcode D353315, 369756, and 385637) suggested the 

potential for chronic risk to non-target mammals, birds, reptiles and terrestrial-phase amphibians 

based on modeled exposure resulting from spray applications of fluopyram. RQs for acute 

exposure were not calculated in the previous risk assessment due to non-definitive endpoints that 

were higher than the highest concentrations tested. Because of this, the author of previous 

assessment presumed low acute risk concerns (at levels below the levels of concern) exist for

mammals, birds, reptiles and terrestrial-phase amphibians. An addendum was submitted to the 

Environmental Fate and Ecological Risk Assessment for Fluopyram Registration to correct the 

endpoints and risk quotients reported for the mammalian toxicity studies (DP Barcode: 396805). 

The corrected calculations still indicated chronic risk concerns using dose-based RQs, although a 

noticeable shift in magnitude occurs. All dietary-based RQs are below the level-of-concern.

The second assessment for in-furrow and seed treatment applications (DP Barcode 414232) 

showed low risk to aquatic organisms and terrestrial plants. Acute risk was indicated from both 

seed treatments. Soybean seed treatments may potentially adversely affect listed small avian 

taxa (20g weight class) on acute basis and cotton seed treatments may potentially adversely 

affect both small and medium listed avian and mammalian taxa (20 g and 100 g for birds and 15 

and 35g for mammals) on an acute basis. There was chronic risk indicated for both avian and 

mammalian taxa from all four of the proposed new uses.

This assessment considers use patterns for eleven new labels (Appendix I, Tables I-1 to I-11) 

which covers new and already registered crops (i.e., amendments to labels). In addition, this 

assessment uses the surface water concentration calculator (SWCC) for modeling exposure EECs 

for surface/pore waters and sediment resulting from all uses (current/amended plus new).
3

II. Current/Amended and New Use Patterns

In previous ecological risk assessments, the following labels were considered:

1) Labels considered in the 1st assessment were for five labels: LUNA® PRIVILEG, 

PROPULSETM, LUNA® TRANQUILITY, LUNA® EXPERIENCE, and LUNA® 

SENSATION. These labels covered many crops at the time of registration of the new 

chemical fluopyram; and

2) Labels considered in the 2nd assessment were for FluopyramST (EPA Reg. No. 264-xxx)

and the amended label of Luna® Privilege (EPA Reg. No. 264-1078). FluopyramST label 

(a.i: fluopyram alone) covered use of fluopyram as a seed treatment for cotton (0.066 lb. 

a.i/A) and soybeans (0.138 lb. a.i/A). In contrast, the amended Luna® Privilege (a.i: 

fluopyram alone) covered in-furrow ground application for cotton at planting (0.222 lb. 

a.i/A) and in-furrow plus ground/air foliar applications for peanuts (two applications at 0.22 

lb. a.i. with 14-day interval).

In this assessment, the proposed eleven new or amended labels cover seed treatment for peanuts 

and soil/foliar applications by ground/air/air blast/chemigation for many crops and foliar/drench 

applications by ground/chemigation for turf and ornamentals. The eleven new or amended labels 

are for products with formulations containing fluopyram alone and formulations containing 

fluopyram with other active ingredients. Table 1 contains a list of these products.

Table 1. List of the proposed products containing the active ingredient alone or with others

Item Product Name 1 Reg. No. Active Ingredient(s) Use Purpose

 1

FLUOPYRAM 500 

SC 

432-

xxxx Fluopyram alone

Fungicide/Nematicide

In Turf & Ornamentals

 2*

LUNA® 

PRIVILEGE 

264-

1078 Fluopyram alone

Fungicide

In Crops (refer to

Appendix I, Tables I1 to I-11 )

3* PROPULSETM

264-

1084

Fluopyram & 

Prothioconazole

4*

LUNA®

TRANQUILITY 

264-

1085

Fluopyram & 

Pyrimethanil

5*

LUNA®

EXPERIENCE 

264-

1091

Fluopyram & 

Tebuconazole

6*

LUNA® 

SENSATION 

264-

1090

Fluopyram & 

7-9 Trifloxystrobin

FLU+TFS SC 

25/32.5/500 

432-

xxxx

Fungicide/Nematicide

10 13ESP715 3.3 SC In Turf & Ornamentals

432-

xxxx Fluopyram alone

11 13ESP715 3.3 SC

432-

xxxx Fluopyram alone

Nematicide

In Turf & Ornamentals

1

for items 2*, 3*, 4*, 5*, and 6*: labels for these products are amended by mainly by 

adding more crops while items 1, 7, 8, 9, 10 and 11are proposed new labels
4

A summary of important label information is included in Appendix I, Tables I-1 to I-11.

III. Estimating Exposure EECs from Surface Water Sources

The Surface Water Concentration Calculator (SWCC) was used to calculate surface water EECs

base on application/chemical parameters and crop representative scenarios (Tables 2 and 3). Tier 

II SWCC estimates pesticide concentrations in water bodies that result from pesticide 

applications to land. This model is designed to simulate the environmental concentration of a 

pesticide in the water column and sediment. The model uses PRZM version 5.0+ (PRZM5) and 

the Variable Volume Water Body Model (VVWM), replacing the older PE-5 shell, which used 

linked PRZM3 (Carousel et al., 2005) and EXAMS (Burns, 2003). For more information about 

the SWCC model refer to the EPA web1.

Application parameters/scenarios

The following steps were taken for modeling surface water EECs using the SWCC model:

(1) Extraction of modeling parameters: This was based (1) current labels with associated use 

patterns and (2) suggested new or amended labels with use patterns summarized in 

(Appendix I, Tables I-1 to I-11). Extracted modeling parameters were for soil/foliar 

applications and seed treatment include: maximum single rates (MSRs in Kg/ha), maximum 

number of applications (MNAs), maximum yearly application (MYAs Kg/ha/year), and first 

application dates (FADs) in addition to the application procedure (G= ground; A= aerial; 

AB= air blast). It is noted that: (a) chemigation and drench were considered as ground 

applications to the soil and (b) seed treatments were considered as application to depths equal 

seeding depths of the crops;

(2) Assignment of crop scenarios to represent various use patterns; and

(3) Made sure to include various types of formulations containing fluopyram alone and mixtures 

in determining the highest application rates of the active ingredient fluopyram; the subject of 

this memo.

Table 2 contains a summary of the extracted application parameters and scenarios for SWCC 

modeling which represent current and amended proposed labels for seed treatments of cotton, 

soybeans and peanuts.

Table 2. Summary of modeled application parameters for fluopyram use as seed treatment

Application Type 1 Scenario 2

Application Rate (Kg/ha) MAI/F

AD

(Days) 4

APCrop Single PR 3 Total/Year Depth (cm) 4

Seed Treatment

STXcottonNMC

0.074

0.500

At 

planting G 1.27

Cotton 5

1

st Foliar Application 0.250 153

A/G

Surface

2

nd Foliar Application 0.176 160 Surface

 

1 URL: http://www.epa.gov/oppefed1/models/water/
5

Seed Treatment

MSsoybeanSTD

0.155

0.500

At 

planting G 1.91

Soybeans 5

1

st Foliar Application 0.250 158

A/G

Surface

2

nd Foliar Application 0.095 165 Surface

Seed Treatment

NCpeanutSTD

0.318

0.500

At 

planting G 3.81

Peanuts 5

1

st Foliar Application None None

A/G

Surface

2

nd Foliar Application 0.182 140 Surface

1 Assume planting with treated seeds followed by applying one or two foliar applications to the maximum yearly 

application of 0.5 kg a.i/ha;

2 Crop scenario that gives the highest EDWC for the crop in question;

3 Assume seed treatment (for cotton= 0.074 Kg a.i/ha; for soybeans= 0.155 Kg a.i/ha; and for peanuts= 0.318 Kg a.i/ha) 

followed by the 1st application= the maximum single foliar application for the crop and the 2nd foliar application= 0.500 

minus (seed treatment + 1st application);

4 Depth (cm) = Minimum reported seeding depth; noting that this depth is variable depending on the geographic location 

and climatic conditions where the crop is planted;

5 The application rates for seed treatments were calculated as follows: (1) For cotton: Rate= BEAD maximum seeding 

rate of 85,000 seeds/A: Application Rate= 0.07716 X (85,000/100,000)= 0.066 lb. a.i /A (0.074 Kg/ha); (2) For soybean: 

Rate= BEAD maximum seeding rate of 250,000 seeds/A: Application Rate= 0.07716 X (250,000/140,00)= 0.137786 lb a.i 

/A; and (3) For peanuts: Rate= 0.124475 lbs a.i/100 lbs of seeds= 0.00124475 lb a.i/lb of seed; given that Lbs seed/A= 

105,000 seeds/460= 228.261 lbs of seeds, the rate is equal to 0.00124475 lb a.i/lb of seed x 228.261 lbs seeds/A= 0.284 

lbs a.i/A (refer to amended LUNA® PRIVILEGE label). All seeding rates are based on the maximum seeding rate 

published by BEAD.

In modeling for applications that include seed treatments in cotton, soybean and peanuts, the 

application of seeds were @ depth (equal to seeding depth), followed by one or two foliar 

application(s) by air. Additionally, Table 3 contains a summary of the extracted application 

parameters and scenarios for SWCC modeling which represent current/amended/newly proposed 

labels for various crops and turf and ornamentals.

Table 3 Summary of modeled application parameters for fluopyram use on crops

Crop 

Group Crop(s) Scenario

MS

R

MN

A

MY

R MAI AP-PR FADs

Artichoke Artichoke CARowCropRLF_V2 0.25 2 0.50 7

Air

And 

Ground

Due to the fact 

that this chemical 

may be applied 

throughout the 

growing season, 

SWCC batch runs 

were used by 

applying the 

pesticide over a 

240 day time 

window at 5-day 

steps starting the 

1

st application at 

14 days after 

Beans

& Peas 

Beans

ILbeansNMC 0.20 2 0.40 7

MIbeansSTD 0.20 2 0.40 7

WAbeansNMC 0.20 2 0.40 7

Snap bean ORsnbeansSTD 0.19 2 0.38 10

Brassica 

Vegetables

Cabbage FLcabbageSTD 0.25 2 0.50 5

Cole crops CAColeCropRLF_V2 0.25 2 0.50 5

Bulb 

Vegetables

Onion

CAonion_WirrigSTD 0.25 2 0.50 5

GAOnion_WirrigSTD 0.25 2 0.50 5

WAonionsNMC 0.25 2 0.50 5

Garlic CAGarlicRLF_V2 0.25 2 0.50 5
6

Canola Canola NDcanolaSTD 0.25 2 0.50 12 emergence and 

the 2nd application 

at 14+the 

application 

interval. For 

example, 

artichoke: 

CARowCropRLF

_V2 was run for 

240 days at 5-day 

steps with the 1st

application at 14 

days after 

emergence and 

the 2nd application 

at 14+7= 21 days.

Maximum 

EDWCs represent 

results obtained 

for the growing 

season not the 

240-day time 

window

Carrot Carrot FLcarrotSTD 0.25 2 0.50 5

Cereal 

Grains 

Crops 

And

Forage, 

Fodder 

or 

Straw 

Corn

CAcornOP 0.25 2 0.50 14

IAcornstd 0.25 2 0.50 14

ILCornSTD 0.25 2 0.50 14

INCornStd 0.25 2 0.50 14

KSCornStd 0.25 2 0.50 14

MNCornStd 0.25 2 0.50 14

MScornSTD 0.25 2 0.50 14

NCcornESTD 0.25 2 0.50 14

NCcornWOP 0.25 2 0.50 14

NDcornOP 0.25 2 0.50 14

NECornStd 0.25 2 0.50 14

OHCornSTD 0.25 2 0.50 14

PAcornSTD 0.25 2 0.50 14

STXcornNMC 0.25 2 0.50 14

TXcornOP 0.25 2 0.50 14

Sorghum

KSsorghumSTD 0.25 2 0.50 14

TXsorghumOP 0.25 2 0.50 14

Sweet 

Corn

FLsweetcornOP 0.25 2 0.50 14

ORswcornOP 0.25 2 0.50 14

Wheat & 

Barley

CAWheatRLF 0.25 2 0.50 14

NDwheatSTD 0.25 2 0.50 14

ORwheatOP 0.25 2 0.50 14

TXwheatOP 0.25 2 0.50 14

Christmas 

Trees

Christmas 

trees ORXmasTreeSTD 0.25 2 0.50 7 AirBlast

MSR= Maximum single rate (Kg/ha), MNA= Maximum number of applications, 

MYA= Maximum yearly application (Kg/ha/year), AP-PR= Application procedure, and the FAD(s)= First 

application date(s)

Table 2 (continued)

Crop Group Crop(s) Scenario

MS

R

MN

A

MY

R MAI AP-PR FADs

Citrus Citrus

CAcitrus_WirrigSTD 0.25 2 0.50 7

AirBlast

Same 

As 

Above

FLcitrusSTD 0.25 2 0.50 7

STXgrapefruitNMC 0.25 2 0.50 7

Cotton cotton

CAcotton_WirrigSTD 0.25 2 0.50 7

STXcottonNMC 0.25 2 0.50 7 Air 
7

TXcottonOP 0.25 2 0.50 7

And 

Ground

MScottonSTD 0.25 2 0.50 7

NCcottonSTD 0.25 2 0.50 7

Cucurbits

Melons

CAMelonsRLF 0.25 2 0.50 5

STXmelonNMC 0.25 2 0.50 5

MImelonStd 0.25 2 0.50 5

MOmelonStd 0.25 2 0.50 5

NJmelonStd 0.25 2 0.50 5

Cucumber FLcucumberSTD 0.25 2 0.50 5

Fruiting 

Vegetables

Peppers FLpeppersSTD 0.25 2 0.50 5

Tomato

CAtomato_WirrigSTD 0.25 2 0.50 5

FLtomatoSTD_V2 0.25 2 0.50 5

PAtomatoSTD 0.25 2 0.50 5

All PAvegetableNMC 0.25 2 0.50 5

All STXvegetableNMC 0.25 2 0.50 5

Ginseng Ginseng MNsugarbeetSTD 0.25 2 0.50 5

Grapes & 

Small Vine 

Fruits Grapes

CAWineGrapesRLF_V2 0.25 2 0.50 12

AirBlast CAgrapes_WirrigSTD 0.25 2 0.50 12

NYGrapesSTD 0.25 2 0.50 12

Grasses: 

Forage/Seeds 

Hay CArangelandhayRLF_V2 0.25 2 0.50 14

Air 

And 

Ground

Seeds ORgrassseedSTD 0.25 2 0.50 14

Herbs 

& Spices

Mustard CAColeCropRLF_V2 0.25 2 0.50 7

Dill weed ORmintSTD 0.25 2 0.50 7

Parsley/Celery CARowCropRLF_V2 0.25 2 0.50 7

Hops Hops ORhopsSTD 0.25 2 0.50 7

Leafy/ Petiole

Vegetables 

Lettuce/Spinach CAlettuceSTD 0.25 2 0.50 7

Celery CARowCropRLF_V2 0.25 2 0.50 7

Fennel CAonion_WirrigSTD 0.25 2 0.50 7

Legume 

Vegetables

Soybean MSsoybeanSTD 0.25 2 0.50 7

Snap bean ORsnbeansSTD 0.25 2 0.50 7

Ornamentals Residential CAresidential/imperviousRLF* 0.25 2 0.50 7 Ground March 15

MSR= Maximum single rate (Kg/ha), MNA= Maximum number of applications, 

MYA= Maximum yearly application (Kg/ha/year), AP-PR= Application procedure, and the FAD(s)= 1st application date(s)

* For this run, used LA weather (W13970.dvf) with application to impervious surfaces (5% of the applied); drift= 0%
8

Table 2 (continued)

Crop Group Crop(s) Scenario

MS

R

MN

A

MY

R MAI AP-PR FADs

Ornamentals Nurseries

CAnurserySTD_V2 0.25 2 0.50 5

Ground

(G)

Same 

As 

Above

FLnurserySTD_V2 0.25 2 0.50 5

MInurserySTD_V2 0.25 2 0.50 5

NJnurserySTD_V2 0.25 2 0.50 5

ORnurserySTD_V2 0.25 2 0.50 5

TNnurserySTD_V2 0.25 2 0.50 5

Peanut Peanuts NCpeanutSTD 0.25 2 0.50 14 A & G

Pome Fruits

Apples NCappleSTD 0.25 2 0.50 7

AirBlast

Apples ORappleSTD 0.25 2 0.50 7

Apples PAappleSTD_V2 0.25 2 0.50 7

Pear and

Quince

WAorchardsNMC 0.25 2 0.50 7

CAfruit_WirrigSTD 0.25 2 0.50 7

Potato and 

Tuberous & 

Corm 

Vegetables

Potatoes

CAPotatoRLF_V2 0.25 2 0.50 5

Air (A)

& 

Ground

FLpotatoNMC 0.25 2 0.50 5

IDNpotato_WirrigSTD 0.25 2 0.50 5

MEpotatoSTD 0.25 2 0.50 5

WApotatoNMC 0.25 2 0.50 5

Sweet Potato NCSweetPotatoSTD 0.25 2 0.50 5

Small 

Berries

Black/

Rasp Berries

ORberriesOP 0.25 2 0.50 7

CAWineGrapesRLF_V2 0.25 2 0.50 7

Stone Fruits

All

CAfruit_WirrigSTD 0.25 2 0.50 5

AirBlast

WAorchardsNMC 0.25 2 0.50 5

Peaches GAPeachesSTD 0.25 2 0.50 5

Cherries MICherriesSTD 0.25 2 0.50 5

Strawberry Strawberries

CAStrawberrynonplasticRLF_V2 0.25 2 0.50 7

Air

& 

Ground

FLstrawberry_WirrigSTD 0.25 2 0.50 7

Sugar beet Sugar beet

CAsugarbeet_WirrigOP 0.25 2 0.50 5

MNsugarbeetSTD 0.25 2 0.50 5

Sunflower Sunflower CAcornOP 0.25 2 0.50 14

Tree Nuts 

almonds CAalmond_WirrigSTD 0.25 2 0.50 7

AirBlast

Pecans GAPecansSTD 0.25 2 0.50 7

Tree nuts ORfilbertsSTD 0.25 2 0.50 7

Turf turf

CATurfRLF 0.25 2 0.50 7

FLturfSTD 0.25 2 0.50 7 Ground
9

PAturfSTD 0.25 2 0.50 7

MSR= Maximum single rate (Kg/ha), MNA= Maximum number of applications, MYA= Maximum yearly application 

(Kg/ha/year), AP-PR= Application procedure, and the FAD(s)= First application date(s)

In modeling for the various crops, the application(s) was/were aerial/foliar applications for 

labeled crop use patterns that include both aerial and ground; aerial application is expected to 

give higher exposure. Crops labeled for ground or air blast applications were modeled as per the 

labels.

Chemical and other parameters

No new fate and transport studies were submitted for fluopyram therefore the chemical 

parameters used for modeling were similar to all previous assessments and are summarized in 

Table 4. These parameters are as per the SWCC model input guidance2.

Table 4 Summary of SWCC input parameters for modeling fluopyram

Input Parameter (Unit) Value Reference (MRID No.)

Molecular Weight g/mole 396.72 Product chemistry

Koc (Average in L/Kg) 439 473723-01

Water Column Metabolism Half-life 

(days) 1,360

Water Reference Temperature 473723-11 oC 20

Benthic Metabolism Half-life (days) 1,757

Benthic Reference Temperature 473723-12/13 oC 20

Aqueous Photolysis Half-life (days) 57

Photolysis Reference Latitude 40 473723-04

Hydrolysis Half-life (days) Stable= 0 473723-03/07

Aerobic Soil Half-life (days) 464

Soil Reference Temperature 473723-07 to 09 oC 25

Vapor Pressure (VP in torr) 9.01 x 10-9

Solubility in Water(mg/L) 16 Product chemistry

Henry’s Law Constant (unitless) 1.20 x 10-8 Calculated from VP

Air Diffusion Coefficient (cm2/day) 0.0

Heat of Henry (J/mol) 0.0 Product chemistry

Application rate and intervals

Application Method Depends on the crop label

Application Efficiency 95% for aerial and 99% for ground

Spray Drift Fraction Aerial (0.125); Ground (0.062) and Airblast (0.042)

Modeling results

Tier II SWCC results for modeled seed treatment are summarized in Table 5.

 

2 SWCC model input guidance: URL: http://www.epa.gov/pesticides/science/efed/models/water/swcc/SWCC.pdf
10

Table 5. Summary of modeled surface/pore waters and sediment EECs resulting from 

application of fluopyram as seed treatments (scenarios giving the highest EECs)

Crop Scenario

Surface Water (ppb) Pore Water (ppb) Sediment (μg/Kg dry)

Peak 21-day 60-day Peak 21-day Peak 21-day

Cotton STXcottonNMC 19.6 19.8 18.10 16.5 16.5 295 295

Soybeans MSsoybeanSTD 15.8 15.5 15.20 14.7 14.7 263 263

Peanuts NCpeanutSTD 7.9 7.8 7.66 7.15 7.15 128 128

Additionally, Tier II SWCC results for modeled crop uses are included in Table 6. The results 

included are for the highest exposure EECs resulting from fluopyram application to various 

crop/crop groups; representative scenario giving the highest EEC for the crop/crop group are only 

included. 

Table 6 Highest EECs resulting from application of fluopyram to crops/crop groups

Crop Scenario (Giving the Highest EECs)

Surface Water (ppb) Pore Water (ppb) Sediment (μg/Kg dry)

Peak 21-day 60-day Peak 21-day Peak 21-day

Artichoke Artichoke 21.6 21.3 21.0 19.9 19.9 356 356

Beans & Peas ILbeansNMC 47.8 47.0 46.2 44.4 44.4 795 795

Brassica Leafy Vegetables CAColeCropRLF_V2 37.3 36.7 36.0 34.6 34.6 619 619

Bulb Vegetables GAOnion_WirrigSTD 23.6 23.2 22.9 21.5 21.5 385 385

Canola NDcanolaSTD 31.5 31.1 30.9 30.3 30.3 542 542

Carrot FLcarrotSTD 40.2 38.3 36.4 33.0 32.6 591 584

Cereals: Corn and Sorghum MScornSTD & KSCornStd 50.1 49.3 48.2 46.4 46.4 831 831

Cereals: Wheat & others TXwheatOP 51.3 49.9 48.9 44.9 44.9 804 804

Christmas Trees ORX-mass trees STD 6.9 6.8 6.7 6.4 6.4 115 115

Citrus FLcitrusSTD 20.6 20.2 19.4 17.4 17.4 311 311

Cotton STXcottonNMC & NCcottonSTD 31.7 30.7 30.5 29.8 29.8 533 533

Cucurbits STXmelonNMC & FLcucumberSTD 39.2 38.2 36.2 32.4 32.5 580 582

Fruiting Vegetables STXvegetableNMC & FLpeppersSTD 40.7 39.6 38.6 34.8 34.8 623 623

Ginseng MNsugarbeetSTD 34.1 33.7 33.3 32.2 32.2 576 576

Grapes & Small Vine Fruits NYGrapesSTD 19.6 19.4 19.2 19.0 19.0 340 340

Grasses for Forage/Seeds ORgrassseedSTD 21.4 21.0 20.6 19.4 19.4 347 347

Herbs & Spices CAColeCropRLF_V2 36.7 36.2 35.6 34.2 34.1 612 610

Hops ORhopsSTD 24.0 23.7 23.5 22.9 22.9 410 410

Leafy Vegetables + Petiole CAlettuceSTD 40.3 39.8 39.2 38.1 38.1 682 682

Legume Vegetables W/Soybeans MSsoybeanSTD 37.6 37.2 37.1 35.4 35.4 634 634

Ornamentals: Residential CAresidential/imperviousRLF 4.6 4.5 4.4 Not Determined (expect to be low)

Ornamentals: Nurseries MInurserySTD 29.6 29.3 29.4 28.4 28.4 508 508

Peanut NCpeanutSTD 32.4 32.0 31.6 30.1 29.8 539 533

Pome Fruits NCappleSTD 19.3 18.4 17.2 15.4 15.4 276 276

Potato, Tuberous/Corm Vegies MEpotatoSTD 50.2 49.9 49.6 49.0 49.0 877 877
11

Crop Scenario (Giving the Highest EECs)

Surface Water (ppb) Pore Water (ppb) Sediment (μg/Kg dry)

Peak 21-day 60-day Peak 21-day Peak 21-day

Small Berries CAWineGrapesRLF_V2 13.3 13.4 13.1 12.5 12.5 224 224

Stone Fruits MICherriesSTD 20.2 20.0 19.7 19.5 19.5 349 349

Strawberry CAstrawberry –non-plasticRLF 40.7 40.0 39.1 36.4 36.3 652 650

Sugar beet MNsugarbeetSTD 34.1 33.7 33.3 32.2 32.2 576 576

Sunflower CAcornOP 18.1 17.8 17.6 16.9 16.9 303 303

Tree nuts GAPecansSTD 21.2 21.2 21.3 21.0 21.1 376 378

Turf PAturfSTD 16.5 16.2 15.8 15.6 15.6 279 279

IV. Effects Summary

Table 7 shows the acute and chronic effects data that were used for estimating risk to aquatic 

animals and plants. 

Table 3. Toxicity reference values for aquatic organisms exposed to fluopyram 

technical or formulated fluopyram (Fluopyram SC 500A, 41.5% active 

ingredient).

Exposure 

Scenario

% Active 

Ingredient

Species Exposure 

Duration

Toxicity 

Reference 

Value

Reference

Classification

Freshwater Fish

Acute

TGAI Rainbow Trout

96 hours

LC50>1.78 mg 

a.i./L MRID 47372328

94.70% Oncorhynchus 

mykiss

NOAEC=1.78 

mg a.i./L Acceptable

TEP Rainbow Trout

96 hours

LC50 >46.4 

mg a.i./Lb MRID 47372333

41.50% Oncorhynchus 

mykiss

NOAEC=1.31 

mg a.i./L Supplemental

Chronic

TGAI

Fathead minnow 

Pimephales 

promelas

33 days

NOAEC = 

0.135 mg 

a.i./L

MRID 47372336

94.70%

LOAEC = 

0.269 mg 

a.i./L

Acceptable

Freshwater Invertebrates

Acute

TGAI Water flea

48 hours

EC50>17 mg 

a.i./L MRID 47372324

94.70% Daphnia magna NOAEC=17 

mg a.i./L Acceptable

TEP Water flea

48 hours

EC50>38.2 mg 

a.i./L MRID 47372325

41.50% Daphnia magna NOAEC=11.6 

mg a.i./L Acceptable
12

Chronic

TGAI Water flea

21 days

NOAEC = 

1214 μg a.i./L MRID 47372334

94.70% Daphnia magna LOAEC = 

2996 μg a.i./L Acceptable

Estuarine/Marine Fish

Acute

TGAI Sheepshead 

minnow

96 hours

LC50 >0.98 

mg a.i./La MRID 47372330

94.70% Cyprinodon

variegatus

NOAEC=0.98 

mg a.i./L Acceptable

Chronic No Data

Estuarine/Marine Invertebrates

Acute

TGAI Saltwater mysid 

Americamysis 

bahia

96 hours

EC50>0.51 mg 

a.i./L MRID 47372327

94.70% NOAEC=0.27 

mg a.i./L Acceptable

Chronic No Data

Freshwater Benthic Invertebrates

Acute No Data

Chronic

TGAI Midge 

54 days

Sediment 

concentrations MRID 47372339

94.70% Chironomus tentans

NOAEC = 26 

mg a.i./kg 

sediment

Supplemental

LOAEC = 48 

mg a.i./kg 

sediment

Pore water

concentrations

NOAEC = 3.8 

mg a.i./L pore 

water

LOAEC = 8.8 

mg a.i./L pore 

water

Estuarine/Marine Benthic Invertebrates

Acute

TGAI Saltwater amphipod

10 days

Sediment 

value: MRID 47372338

94.70% Leptocheirus 

plumulosus

LC50 > 100

mg a.i./kg 

sediment

Acceptable
13

NOAEC=100 

mg a.i./kg 

sediment

Pore water 

value:

LC50 > 7.5 mg 

a.i./L pore 

water

NOAEC = 7.5 

mg a.i./L pore 

water

Chronic

TGAI Saltwater amphipod

28 days

Sediment 

concentrations MRID 47372335

94.70% Leptocheirus 

plumulosus

NOAEC = 36 

mg TRR/kg 

sediment

Supplemental

LOAEC = 92 

mg TRR/kg 

sediment

Pore water 

concentrations

NOAEC = 2.5 

mg TRR/L 

pore water

LOAEC = 5.9 

mg TRR/L 

pore water

Aquatic Plants

TGAI

Pseudokirchneriella 

subcapitata 96 hours

EC50 = 4.3 mg 

a.i./L MRID 47372403

94.70% NOAEC = 

1.46 mg a.i./L Acceptable

(biomass)

TEP

Pseudokirchneriella 

subcapitata 72 hours

EC50 = 3.4 mg 

a.i./L MRID 47372407

41.50% NOAEC = 

1.17 mg a.i./L Acceptable

(cell density)

Fluopyramlactame 

(metabolite)

Pseudokirchneriella 

subcapitata 72 hours EC50 >8.87 mg a.i./L MRID 47372418
14

94% NOAEC = 

8.87 mg a.i./L Acceptable

(for both cell 

density and 

growth rate)

Macrophyte TGAI Duckweed

7 days

EC50 = 2.6 mg 

a.i./L MRID 47372401

94.70% Lemna gibba NOAEC = 

0.28 mg a.i./L Acceptable

(frond number 

based on 

yield)

TEP Duckweed

7 days

EC50 = 2.9 mg 

a.i./L MRID 47372402

41.60% Lemna gibba NOAEC = 

1.04 mg a.i./L Acceptable

(frond number 

based on 

yield)

a These values were used for evaluation of risk via spray drift only.

Table 8 shows the acute and chronic effects data that were used for estimating risk to terrestrial 

animals and plants. 

Table 4. Toxicity reference values for terrestrial organisms exposed to 

fluopyram technical or formulated fluopyram (Fluopyram SC 500A, 41.5% 

active ingredient). 

Exposure 

Scenario

% Active 

Ingredient Species Exposure Duration

Toxicity 

Reference Reference

Value

Mammals

Acute

TGAI Laboratory 

Rat 

Single oral 

dose 

LD50 > 2000 

mg a.i./kg 

bw

MRID

(94.7% a.i.) (Rattus 

norvegicus) 47372430

Acceptable

Chronic TGAI

Laboratory 

Rat (Rattus 

norvegicus)

90-day 

dietary 

study

NOAEL = 

13 mg a.i./kg 

bw/day 

MRID 

47372441
15

(94.7% a.i.)

LOAEL = 61 

mg a.i./kg 

bw/day

Acceptable

Birds

Acute

TGAI

Northern 

bobwhite quail 

(Colinus 

virginianus) 

and zebra 

finch 

(Taeniopygia 

guttata)

Single oral 

dose 

LD50 >2000 

mg a.i./kg 

bw

MRIDs 

47372341 

(94.5% a.i. 

[bobwhite] and 

94.7% a.i 

[zebra finch]).

Acceptable

and 

47567007

Supplemental

Acute

TGAI

Northern 

bobwhite quail 

(Colinus 

virginianus)

5-Day 

dietary 

LC50 >4785 

mg a.i./kg 

diet

MRID 

47372343

(95.0% a.i.)

Acceptable 

Chronic

TGAI Bobwhite 

quail

Avian 

reproduction 

study 

(dietary 

exposure, 

one 

generation) 

NOAEC = 

46.7 mg 

a.i./kg dieta

MRIDs 

47372344

(94.7% a.i.)

(Colinus 

Virginianus) 

and Mallard 

duck (Anas 

platyrhynchos)

Acceptable

LOAEC = 

75.7 mg 

a.i./kg dieta

47372345

Supplemental

47372346

Acceptable

Terrestrial Insects

Acute TGAI Honey bee 96-Hour 

acute 

Contact 

toxicity

MRID 

47372347
16

(95.5% a.i.) (Apis 

mellifera)

contact and 

oral toxicity 

test 

LD50 >100 

μg test 

material/bee

Contact 

toxicity test:

Acceptable

Oral toxicity

LC50 >102.3 

μg test 

material/bee

Acute

TEP Honey bee

96-Hour 

acute 

contact and 

oral toxicity 

test 

Contact 

toxicity

MRID 

47372348

(41.6% a.i.) (Apis 

mellifera)

LD50 > 83.2 

μg a.i./bee

Contact 

toxicity test:

Oral toxicity Acceptable

LC50 > 89 μg 

a.i./bee

Plants - Tier I seedling emergence

Monocot

TEP Oat (Avena 

sativa), perennial 

ryegrass (Lolium 

perenne), barley

(Hordeum vulgare) 

and corn (Zea 

mays)

Single 

application 

at test 

initiation

EC25 >0.444 

lbs a.i./A

MRID 

47372349

(41% a.i.)

NOAEC = 

0.444 lbs 

a.i./A

Acceptable

Dicot

TEP

Sugarbeet (Beta 

vulgaris), oilseed 

rape (Brassica 

napus), soybean 

(Glycine max), 

cucumber 

(Cucumis sativus), 

buckwheat 

(Fagopyrum 

esculentum) and 

sunflower 

(Helianthus 

annuus)

Single 

application 

at test 

initiation

EC25 <0.444 

lbs a.i./A

MRID 

47372349

(41% a.i.)

NOAEC 

<0.444 lbs 

a.i./A

Acceptable

Plants - Tier II seedling emergence

Dicot TEP Buckwheat Full test EC25 <0.444 

lbs a.i./A

MRID* 

48934301
17

(42% a.i.) (Fagopyrum 

esculentum)

NOAEC 

0.444 lbs 

a.i./A

Supplemental

Plants - Tier I vegetative vigor

Monocot

TEP Onion (Allium 

cepa), oat

(Avena 

sativa), 

perennial 

ryegrass

(Lolium 

perenne) and 

corn (Zea 

mays)

Single

application 

at test 

initiation

EC25 >0.222 

lbs a.i./A

MRID 

47372350

(41% a.i.)

NOAEC = 

0.222 lbs 

a.i./A

Acceptable

Dicot

TEP

sugarbeet 

(Beta 

vulgaris), 

oilseed rape

(Brassica 

napus), 

cucumber

(Cucumis 

sativus), 

buckwheat 

(Fagopyrum 

esculentum), 

soybean 

(Glycine max) 

and sunflower

(Helianthus 

annuus)

Single 

application 

at test 

initiation

EC25 >0.222 

lbs a.i./A MRID 

(41% a.i.)

NOAEC = 

0.222 lbs 

a.i./A

47372350

Acceptable

*Bolded MRID indicates newly submitted study for this assessment.

In response to a supplemental study examining seedling emergence on the dicot buckwheat, an 

additional seedling emergence study was submitted (MRID 48934301). This study was 

scientifically sound but because this study only examined the dicot buckwheat it is considered 

supplemental. It does however fulfill the guideline requirements when combined with the 

previously submitted seedling emergence study (MRID 47372349). At the application rates of 

0.444 lb a.i. /A buckwheat had inhibitions in emergence and survival of up to 5.4%; however 

there was also a slight promotion shoot length and overall no general trend was observed. The 

maximum inhibition in dry weight was 1.9%, but was observed with promotion of dry weight as 

well. There was no effect in the negative control or any treatment group and the NOAEC was 

established as 0.444 lb a.i. / A.
18

V. Risk Estimation

A. Risk Estimation for Aquatic Animals

Risks to aquatic animals from the proposed use of fluopyram are summarized in Appendix 2.

For freshwater animals, no acute or chronic risks were identified either for listed or non-listed 

species. Acute RQs for freshwater fish and invertebrates were all less than 0.03 and did not 

exceed the level of concern for either listed (LOC=0.1) or Nonlisted species (LOC=0.5). 

Chronic fish RQs were all less than 0.36 and chronic invertebrate RQs were all less than 0.04, 

and did not exceed the chronic LOC of 1.0. Acute RQs for estuarine/marine fish were all less 

than 0.05 and did not exceed either listed or Nonlisted LOCs. Acute RQs for estuarine/marine 

invertebrates ranged from <0.1 (three crop groups: cereals (corn and sorghum), cereals (wheat 

and others), and Potato and tuberous/corm vegetables) to <0.01 and did not exceed either the 

listed species LOC (0.1) or the nonlisted species LOC (0.5). No chronic toxicity data are 

available for estuarine/marine invertebrates or fish. When possible the Agency uses the acute to 

chronic ratio (ACR) to bridge missing toxicity data in establishing potential risk to taxa with 

missing data. In this case establishing an ACR was not possible due to non-definitive endpoints 

in the taxa where data did exist. Chronic RQs for sediment invertebrates were all less than 0.03 

and did not exceed the LOC of 1.0 for either freshwater or estuarine/marine invertebrates from 

either porewater or sediment exposure. Given the EECs that were generated from the modeled 

uses, it is reasonable to expect that aquatic animals are at low risk from the proposed uses which 

is similar to the established uses covered in the previous assessment on fluopyram (US EPA 

2011).

B. Risk Estimation for Aquatic Plants

RQs for nonlisted species of both vascular and nonvascular plants were 0.02 or less and did not 

exceed the LOC of 1.0. RQs for listed species of vascular and nonvascular plants also did not 

exceed the LOC of 1.0. RQs for listed species of vascular aquatic plants ranged from 0.02 to 

0.18 while RQs for listed nonvascular plants ranged from 0.01 to 0.04. These are consistent with 

the low risk determinations in previous assessments. The RQs are presented in Appendix 2. 

C. Risk Estimation for Terrestrial Animals

Risks to terrestrial animals were assessed for both spray applications as well as seed treatments. 

In-furrow applications were also assessed in the previous assessment.

Spray Applications 

Terrestrial EECs could be an underestimation of actual exposure concentrations in the 

environment. Although the label stated that fluopyram can be applied via foliar spray application 

up to 2 times per season for the crops with the highest seasonal application rate (watermelons, 

and strawberries), for this risk assessment, EFED assumed that fluopyram was applied at a 

maximum of 2 times per year (Table 9). If there are conditions under which there is more than 
19

one growing season for a crop within a single year, exposure estimates and risk to terrestrial 

organisms could be significantly underestimated. 

Table 9. Input parameters used in T-REX v1.4.1 to determine terrestrial EECs for the maximum 

fluopyram spray application scenario. a 

Input Variable Parameter Value Source

Maximum application rate 0.25 lbs a.i./A

Maximum # of applications per year 2

Minimum application interval 5 days

Foliar half-life 35 days T-REX Default Value 

a Representative of the maximum exposure scenario for all crop uses.

The EECs on food items may be compared directly with dietary toxicity data or converted to an 

oral dose. For mammals, the residue concentration is converted to daily oral dose based on the 

fraction of body weight consumed daily as estimated through mammalian allometric 

relationships. The screening-level risk assessment for fluopyram considers upper-bound 

predicted residues as the measure of exposure. Summaries of the predicted upper-bound and 

mean residues of fluopyram that may be expected to occur on selected avian or mammalian food 

items immediately following application for the maximum use scenario are presented in Table 

10. 

For the maximum fluopyram spray application scenario, acute concentrations on foliar surfaces 

ranged from 7 to 114 ppm for upper-bound residues and 3 to 41 ppm for mean residues. These 

residues are very similar to those modeled in the 2011 assessment (DP Barcode: D352215) with 

maximum application rates of 0.222 lbs a.i./A.

Table 10. Upper-bound and mean terrestrial dietary 

EECs estimated for the maximum fluopyram spray 

application scenario (Kenaga values). a

Forage Type

Upperbound 

Residues 

(ppm)

Mean 

Residues 

(ppm)

Short Grass 

114 41

Tall Grass 

52 17

Broadleaf plants

64 21

Fruits/pods/seeds

7 3

Arthropods 45 31
20

Spray Applications: Acute Risk to Birds and Mammals

Birds

Previous assessments did not calculate acute dose- or dietary-based RQs for birds because 

definitive LD50 and LC50 values were not available. Utilization of the endpoint (LD50 > 2000 

mg/kg bw; MRID 47372341) however indicate that the RQs would be less than 0.09 for the most 

conservative assumption using upper bound residues suggesting that there is low acute risk to 

birds from applications of fluopyram at the maximum application rates.

Mammals

Previous assessments did not calculate acute dose-based RQ values for mammalian receptors 

because the results of the definitive submitted acute oral toxicity studies on mammals did not 

allow calculation of a definitive LD50 values. Utilization of the endpoint (LD50 > 2000 mg/kg 

bw; MRID47372430) however indicate that the RQs would be less than 0.02 for the most 

conservative assumption using upper bound residues suggesting that there is low acute risk to 

mammals from applications of fluopyram at the maximum application rates.

Spray applications: Chronic Risk to Birds and Mammals

Birds

For birds, chronic RQs were derived using a dietary-based chronic toxicity value. Dietary-based 

RQs were calculated using EECs expressed in terms of residue concentration for the various 

forage categories, and the toxicity value (NOAEC) is expressed in units of dietary concentration 

(Table 11). RQs exceeded the LOC of 1.0 for all dietary categories except for fruits/pods/seed 

and indicated the potential for adverse effects from chronic exposure to short grass, tall grass, 

broadleaf plants and arthropods. 

Table 11. Dietary-based chronic RQs for birds exposed to fluopyram 

based on upper-bound residues on short grass, tall grass, broadleaf 

plants/small insects, and fruits/pods/seeds/large insects as calculated by 

T-REX 

Dietary item Avian Chronic Risk Quotients a

Short Grass 2.4

Tall Grass 1.1
21

Bolded values denote RQ values that exceed the LOC of 1.0

Mammals

Dietary-based RQs were calculated using EECs expressed in terms of residue concentration for 

the various forage categories, and the toxicity value (NOAEC) is expressed in units of dietary 

concentration. Dose-based RQs were calculated using EECs expressed in terms of a dose 

concentration for the various forage categories and the estimated toxicity value (NOAEL). The 

dose-based EECs are calculated by using the estimated dietary concentrations and assuming the 

laboratory rat consumes 5% of its body weight daily. Three weight categories (or sizes) were 

considered for dose-based risk calculations (Tables 12 and 13). Chronic RQs for mammals 

exceeded the LOC of 1.0 for dose based exposure but not dietary based exposure. Chronic risk 

was found from dosed based exposure to short grass, tall grass, broadleaf plants and arthropods 

for both small and medium sized birds. Exposure to short grass had the potential to adversely 

affect large birds.

Table 12. Dose-based chronic RQs for small (15g), intermediate (35g), and large 

(1,000g) mammals exposed to fluopyram based on upper-bound residues on 

short grass, tall grass, broadleaf plants/small insects, fruits/pods/large insects 

and seeds as calculated by T-REX 

Mammalian Chronic Risk Quotient*

Short 

Grass

Tall 

Grass

Broadleaf 

Plants Fruits/Pods Arthropods Seeds

Body 

Weight

(g)

15 3.82 1.75 2.15 0.24 1.49 0.05

35 3.26 1.49 1.83 0.20 1.28 0.05

1000 1.75 0.80 0.98 0.11 0.68 0.02

Broadleaf plants 1.4

Fruits/pods/seeds 0.2

Arthropods 1.0

a These values were calculated using the maximum application rate (0.25 lb 

a.i./A), the maximum number of applications (2), the minimum application 

interval (5 days), and a chronic NOAEC = 46.70 mg a.i./kg diet in bobwhite 

quail and a default chemical foliar half-life of 35 days.
22

* These values were calculated using the maximum application rate (0.25 lb a.i./A), 

the maximum number of applications (2), the minimum application interval (5 days), 

a NOAEC = 13 mg a.i./kg body weight/day in rats and an estimated chronic dietary 

NOAEC = 260 mg ai/kg diet and a default chemical foliar half-life of 35 days.

Bolded values denote RQ values that exceed the LOC of 1.0

Table 13. Dietary-based chronic RQs for mammals exposed 

to fluopyram based on upper-bound residues on short grass, 

tall grass, broadleaf plants/small insects, and 

fruits/pods/seeds/large insects as calculated by T-REX

Mammalian Chronic Risk Quotients*

Short 

Grass

Tall 

Grass

Broadleaf 

Plants Fruits/Pods/Seeds Arthropods

0.44 0.20 0.25 0.03 0.17

* These values were calculated using the maximum application 

rate (0.25 lb a.i./A), the maximum number of applications (2), 

the minimum application interval (5 days), and a chronic 

NOAEC = 13 mg a.i./kg body weight/day in rats and an 

estimated chronic dietary NOAEC = 260 mg ai/kg diet and a 

default chemical foliar half-life of 35 days..

a) Seed treatments on soybeans and cotton and peanuts

Risks to both avian and mammalian taxa from seed treatments for peanuts, soybeans and cotton 

are presented in Table 14. The risks from soybeans and cotton were assessed previously (DP 

Barcode 414232). 

For peanuts, the seed treatment resulted in an acute risk to listed small and medium sized avian 

species as well as chronic risk to both listed and non-listed species of birds and mammals in all 

weight classes. An RQ of 0.26 in the avian 20 g category and of 0.12 in the 100 g category 

exceeded the acute listed species LOC of 0.1 indicating listed species in these weight class may 

be adversely affected by acute exposures. Avian chronic RQs were 32 and exceeded the LOC of 

1.0 for chronic exposure. Mammalian chronic RQs ranged from 5 to 11, all exceeding the 

chronic LOC of 1.0, indicating potential chronic adverse effects when exposed to fluopyram 

through peanut seed treatments. There was not any mammalian acute risk identified for any 

mammalian weight class exposed to peanut seed treatments.

For soybeans, the seed treatment resulted in an acute risk to listed avian species as well as 
23

chronic risk to both listed and non-listed species of birds and mammals in all weight classes. An 

RQ of 0.14 in the avian 20 g category exceeded the acute listed species LOC of 0.1 indicating 

listed species in this weight class may be adversely affected by acute exposures. Avian chronic 

RQs were 17.65 and exceeded the LOC of 1.0 for chronic exposure. Mammalian chronic RQs 

ranged from 2.8 to 6.11, all exceeding the chronic LOC of 1.0, indicating potential chronic 

adverse effects when exposed to fluopyram through soybean seed treatments. There was not any 

mammalian acute risk identified for any mammalian weight class exposed to soybean seed 

treatments.

For the cotton seed treatment there was potential risk to avian taxa identified on both an acute 

and chronic basis. The avian weight class of 20g had an RQ of 0.61 and exceeded the nonlisted 

species LOC of 0.5 suggesting potential adverse effects to both listed and non-listed avian 

species in this weight class. The avian weight class of 100 g had a RQ of 0.27 which exceeded 

the LOCs for listed species (LOC= 0.1). This suggests that listed species may potentially be 

adversely affected and risks may be mitigated through restricted use patterns. Chronic risk was 

identified in all avian weight classes with an RQ of 74.11 in each category greatly exceeding the 

chronic LOC of 1.0. The mammalian weight classes of 15g and 35g had RQs of 0.17 and 0.14 

respectively for cotton. These both exceed the LOC for listed species (0.1) and indicate potential 

adverse effects to listed species on an acute exposure basis when exposed to cotton seed 

treatments. Chronic mammalian RQs ranged from 11.75 to 25.66 and all significantly exceeded 

the chronic LOC of 1.0 indicating risk to both listed and non-listed species.

Table 14. Risk quotients for terrestrial animals as a result of seed treatments on peanuts, soybean 

and cotton.

Risk Quotients†

Peanuts

Acute (# 1) Acute (# 2) Chronic

Avian (20 g) 0.26 0.01 32.04

Avian (100 g) 0.12 0.00 32.04

Avian (1000 g) 0.04 0.00 32.04

Mammalian (15 g) 0.07 0.00 11.09

Mammalian (35 g) 0.06 0.00 9.48

Mammalian (1000 g) 0.03 0.00 5.08

Soybean

Acute (# 1) Acute (# 2) Chronic

Avian (20 g) 0.14 0.01 17.65

Avian (100 g) 0.06 0 17.65

Avian (1000 g) 0.02 0 17.65

Mammalian (15 g) 0.04 0 6.11

Mammalian (35 g) 0.03 0 5.22

Mammalian (1000 g) 0.02 0 2.8
24

Cotton

Acute (# 1) Acute (# 2) Chronic

Avian (20 g) 0.61 0.02 74.11

Avian (100 g) 0.27 0 74.11

Avian (1000 g) 0.09 0 74.11

Mammalian (15 g) 0.17 0.01 25.66

Mammalian (35 g) 0.14 0.01 21.92

Mammalian (1000 g) 0.08 0 11.75

Acute RQ #1 = (mg ai /kg-bw/day) / LD50

Acute RQ #2 = mg ai ft-2 /(LD50*bw)

Avian Chronic RQ =mg kg-1 seed / NOAEL

Mammalian Chronic RQ = mg a.i./kg-bw/day / adjusted 

NOAEL

Bolded values denote RQ values that exceed the acute listed species LOC of 0.1 and the chronic LOC of 1.0

D. Risk Estimation for Terrestrial Plants

As reviewed in the previous assessment, in the vegetative vigor study, sugarbeet had the highest 

level of inhibition in dry weight, a 20.2% reduction in comparison to the negative control at a 

fluopyram application rate of 0.222 lbs a.i./A. The rate applied in the Tier I seedling emergence 

test, 0.444 lbs a.i./A, was greater than the maximum application rate of 0.25 lbs a.i./A. The original 

buckwheat study submitted for the previous risk assessment showed a 50.4% reduction in dry 

weight at 0.444 lbs a.i./A in the seedling emergence test (MRID 47372349; US EPA 2011). A 

more recent Tier II study submitted for this assessment (MRID 48934301) demonstrated that there 

were not any observable effects at the maximum application rates of 0.44 lb a.i./A. The NOAEC 

for this study was 0.4440 lb a.i./A.

A preliminary run of TERR-PLANT was conducted using the maximum application scenarios 

for ground application listed in Table 2. All EECs ranged from 0.0025 (spray drift) to 0.0525

(semi-aquatic areas) lbs a.i./A for ground applications. In all scenarios used in this assessment, 

there was not any risk identified to either listed or non-listed monocots and dicots in dry and 

semi-aquatic areas as a result of runoff or spray drift (RQs ranged from <0.1 to 0.12). Similarly, 

the in-furrow treatments also did not exceed the LOC of 1.0. Use of Fluopyram is unlikely to 

adversely affect terrestrial plants when used according to labels.

VI. Risk Summary 

The RQs are summarized in the above tables. Risk associated with the proposed new uses of 

fluopyram are confined primarily to terrestrial taxa. For spray applications there was chronic 

dietary based risk from consumption of all dietary categories but the fruit/pods/seeds category. 

Spray applications also resulted in chronic dosed-based risk to mammalian taxa in every size 

class for short grass for most dietary items for small and medium sized mammals. Exposure to 
25

Fluopyram via seed treatments potentially poses acute risk to small and medium sized 

endangered avian and mammalian species. There was chronic risk indicated for both avian and 

mammalian taxa from all seed treatments. 

Citations:

US. EPA 2011. Environmental Fate and Ecological Risk Assessment for Fluopyram

Registration (PC Code 080302; DP Barcodes 353315, 369756, and 385637)

Appendix I: Labeled uses for fluopyram and mixtures

(1) Abbreviations

A Application using aerial equipment

AirBlast Application using air blast equipment

C Chemigation through the irrigation systems

CG Crop Group

CR Crop

D Drench application to soil

-d Application intervals in days (e.g., 7-d)

F Application directed to foliage

FDC Fungicide Disease Control

FDS Fungicide Disease Suppression

G Application using ground equipment

MSA Maximum Single Rate (lb a.i/A)

MYA Maximum Yearly Rate (lb a.i/A)

NPC Nematode Pest Control

PHI Pre-harvest interval (days)

S Application directed to soil

(2) Products: Products are numbered from 1 to 11 in the Tables, below and hereunder the names 

and active ingredient(s) for these products

Products Names and active(s)

Product 

No. Product Name and Active Ingredient(s)

1 FLUOPYRAM 500 SC: a.i: Fluopyram

2 LUNA® PRIVILEGE: a.i: Fluopyram

3 PROPULSETM: a.i: Fluopyram & Prothioconazole

4 LUNA® TRANQUILITY: Fluopyram & Pyrimethanil

5 LUNA® EXPERIENCE: Fluopyram & Tebuconazole

6 LUNA® SENSATION: Fluopyram & Trifloxystrobin

7 FLU+TFS SC 25: a.i: Fluopyram + Trifloxystrobin
26

8 FLU+TFS SC 32.5: a.i: Fluopyram + Trifloxystrobin

9 FLU+TFS SC 500: a.i: Fluopyram + Trifloxystrobin

10 13ESP715 3.3 SC: a.i: Fluopyram (master label: Fungicide + Nematicide)

11 13ESP715 3.3 SC: a.i: Fluopyram (Nematicide only)

Table I-1 Artichoke, Beans and Peas, Brassica and Bulb vegetables (refer to Abbreviations, above)

CR or CG Crops Product Purpose

Artichoke

Artichoke (globe) MSA= Maximum Single Application MSA= 0.223; Maximum Yearly 

Application (MYA)= 0.446; 7-d; Soil or Foliar (S or F); G/A/C/D 

(ground/aerial/chemigation/Drip): MSA= 0.223 ; MYA= 0.446; 7-d; S or F; G/A/C/D; 

PHI=0 2 FDC

Artichoke (globe): MSA= 0.125; MYA= 0.251; 7-d; S or F; G/A/C; PHI=0 6

FDC 

+FDS

Beans and 

Peas (dried)

Bean (Lupinus spp., includes grain lupin, sweet lupin, white lupin, and white sweet lupin), 

Bean (Phaseolus spp., includes field bean, kidney bean, lima bean, navy bean, pinto bean, 

tepary bean), Bean (Vigna spp., includes adzuki bean, blackeyed pea, catjang, Crowder pea, 

moth bean, mung bean, rice bean, southern pea, urd bean, Broad Bean (dry), Chickpea, Guar, 

Lablab Bean, Pea (Pisum spp Pea including Field pea and Pigeon pea), Lentil

MSA= 0.178; MYA= 0.446; 7-d; S or F; G/A/C; PHI=14 3 FDC

Beans only: fresh & dry, except succulent shelled: MSA= 0.167; MYA= 0.334; 10-d; S or 

F; G/A/C; PHI=14 5 FDC

Brassica 

(Cole) Leafy 

Vegetables

Broccoli, Broccoli raab (rapini), Brussels sprouts, Cabbage, Cauliflower, Cavalo broccolo, 

Chinese broccoli (gai lon), Chinese cabbage (bok choy), Chinese cabbage (napa), Chinese 

mustard cabbage (gai choy), Collards, Kale, Kohlrabi, Mizuna, Mustard greens, Mustard 

spinach, Rape greens, Turnip greens. Including all cultivars and/or hybrids of these: FDC: 

MSA= 0.223; MYA= 0.446; 5-d; S or F; G/A/C/D; PHI= 0 and NPC: MSA= 0.223; 

MYA= 0.446; 5-d; For application refer to Note 1 2

FDC + 

NPC

Crop Subgroup 5B: Broccoli raab (rapini), Chinese cabbage (bok choy), Collards, Kale, 

Mizuma, Mustard greens, Mustard spinach, Rape greens, Turnip greens and/or hybrids of 

these: MSA= 0.112; MYA= 0.444; 7-d; S or F; G/A/C/D; PHI= 7 5

FDC + 

FDS

BRASSICA LEAFY VEGETABLES, (HEAD AND STEM SUBGROUP)

Broccoli, Chinese broccoli (gai lon), Brussels sprouts, Cabbage, Chinese cabbage (napa), 

Chinese cabbage (bok choy), Chinese mustard cabbage (gai choy), Cauliflower, Cavalo 

broccolo, Kohlrabi; Including all cultivars and/or hybrids of these: MSA= 0.125; MYA= 

0.251; 7-d; S or F; G/A/C/D; PHI= 0 6

FDC + 

FDS

BRASSICA LEAFY VEGETABLES, (LEAFY GREENS SUBGROUP 5B): Same crops 

listed for product 5: MSA= 0.125; MYA= 0.251; 7-d; S or F; G/A/C; PHI= 0 6

FDC + 

FDS

Bulb 

Vegetables

Chive fresh leaves, Chive fresh leaves (Chinese), Daylily bulb, Elegans hosta, Fritillaria (bulb 

and leaves), Garlic bulb, Garlic bulb (Great headed and Serpent ), Kurrat, Leek, Leek (Lady’s 

and Wild), Lily bulb, Onion (Beltsville bunching, Bulb, Chinese bulb, Fresh, Green, 

Macrostem, Pearl, Potato bulb, Tree tops, and Welsh), Shallot (bulb and fresh leaves). 

Including all cultivars and/or hybrids of these: MSA= 0.223; MYA= 0.446; 5-d; S or F; 

G/A/C; PHI=0 2

FDC + 

FDS

Dry bulb onion, Eschalots, Green onion, Garlic, Leeks, Japanese bunching onion, Scallions, 

Shallot, Spring onion 0.220-0.445/7-d G/A/AB/C: MSA= 0.220; MYA= 0.444000; 7-d; S 

or F; G/A/C; PHI= 7 (up to 0.446) 4

FDC + 

FDS

Same crops as product 1: MSA= 0.167; MYA= 0.434; 10-d; S or F; G/A/C; PHI= 7 5

FDC + 

FDS
27

Note 1: Varies by crop: applied chemical is to reach the root zone by irrigating-in, drench, and chemigation or in 

seed-furrow
28

Table I-2 Canola, Carrots, Cereal grains and X-mass trees (refer to Abbreviations, above)

CR or CG Crops Product Purpose

Canola 

Subgroup

Borage; crambe; cuphea; echium; flax seed; gold of pleasure; hare’s ear mustard; lesquerella; 

lunaria;meadowfoam; milkweed; mustard seed; oil radish; poppy seed; rapeseed; sesame; 

sweet rocket cultivars, varieties; and/or hybrids of these: 

MSA= 0.223 ; MYA= 0.446; 12-d; S or F; G/A/C; PHI= 14 d 2 FDC

Canola, Rapeseed, Indian rapeseed, Field mustard and Crambe: MSA= 0.178; MYA= 0.356; 

14-d; S or F; G/A/C; PHI= 36 (up to 0.446 w/other) 3 FDC

Carrot

Tops or greens may be utilized for food or feed. Beet (garden), Burdock (edible), Celeriac, 

Chervil (Turnip-rooted), Chicory, Horseradish, Parsley (Turnip-rooted), Parsnip, Radish, 

Oriental Radish (Daikon), Rutabaga, Salsify, Salsify (Black and Spanish), Skirret, Turnip: 

MSA= 0.223 ; MYA= 0.446; 5-d; Assume Foliar; G/A/C; PHI= 7 d 2 FDC

Carrot: MSA= 0.125 ; MYA= 0.377; 14-d; Assume Foliar; G/A/C; PHI= 7 d 6

FDC + 

FDS

Cereal 

Grains, 

Except 

Rice

Crops: Barley, Buckwheat, Corn (sweet corn, field corn, field corn grown for seed, and 

popcorn), Millet (pearl and proso), Oats, Popcorn, Rye, Sorghum, Sudan grass, Teosinte, 

Triticale, Wheat Plus: Forage, Fodder or Straw from al cereal grain crops stated above: 

MSA= 0.223; MYA= 0.446; 14-d; S or F; G/A/C; PHI= 14 d 2 FDC

Barley, Wheat (spring, durum, and winter) and Triticale (0.178-0.294/ 14-d) G/A/C

MSA= 0.178; MYA= 0.296; 14-d; S or F; G/A/C; PHI= 30 d (with other=0.446) 3 FDC

Buckwheat, Millet (pearl and proso), Oats and Rye (0.178 0ne application) G

MSA= 0.178 One application; S or F; G/A/C; PHI= 30 d (with other=0.446) 3 FDC

Corn (Assume All): MSA= 0.178; MYA= 0.446; 7-d; S or F; G/A/C; PHI= 14 d for sweet 

corn 3 FDC

Wheat and Barley: MSA= 0.122; one application; S or F; G/A/C; PHI= 30 d 5 FDC

Corn: sweet corn, field corn, field corn grown for seed, and popcorn: MSA= 0.167; MYA= 

0.334; 14-d; S or F; G/A/C; PHI= sweet corn= Min 7 fodder, field corn, field corn grown 

for seed, and popcorn Min 14 days 5 FDC

Wheat: MSA= 0.112; MYA= 0.220; 14-d; S or F; G/A/C; PHI= 35 d (with other=0.446) 6 FDC

Christmas 

Trees

Christmas Trees: MSA= 0.221; MYA= 0.446; 7-d; F; AirBlast 2 FDP

Christmas Trees: MSA= 0.220; MYA= Not specified but assumed to be 0.446; 7-d; F; 

AirBlast 7 FDC

Christmas Trees: MSA= 0.220; MYA= Not specified but assumed to be 0.446; 7-d; F; 

AirBlast 9 FDC

Christmas Trees: MSA= 0.224; MYA= 0.446; 7-d; F; AirBlast 10 FDC
29

Table I-3 Citrus, Cotton and Cucurbits (refer to Abbreviations, above)

CR or CG Crops Product Purpose

Citrus

Australian desert lime, Australian finger-lime, Australian round lime, Brown River finger lime, 

Calamondin, Citron, Citrus hybrids, Grapefruit, Japanese summer grapefruit, Kumquat, Lemon, 

Lime, Mediterranean mandarin, Mount white lime, New Guinea wild lime, Orange (Sour and 

Sweet), Pummelo, Russell River lime, Satsuma mandarin, Sweet lime, Tachibana orange, Tahiti 

lime, Tangelo, Tangerine (Mandarin), Tangor, Trifoliate orange, Uniq fruit, White sapote, 

(Casimiroa spp.) and cultivars, varieties, and/or hybrids of these: FDC: MSA= 0.223; MYA= 

0.446; 7-d; S or F; G/A/C; PHI= 7 d and NPC: MSA= 0.223; MYA= 0.446; 30-d; For 

application refer to Note 1; PHI= 7 d 2

FDC +

NPC

Non-bearing citrus trees: MSA= 0.221; MYA= 0.446; 7-d; F; AirBlast Drip 1 FDC

Non-bearing trees: MSA= 0.221; MYA= 0.446; 30-d; For application refer to Note 1 1 NPC

Lemons: MSA= 0.220 one application; S or F; G/A/C; PHI= 7 d (up to 0.446) 4 FDS

Calamondin, Citrus citron, Citrus hybrids (Citrus spp., includes chironja, tangelo and tangor), 

Grapefruit, Kumquat, Lemon, Lime, Mandarin (tangerine), Orange (sweet and sour), Pummelo, 

Tangelo, Satsuma mandarin, White sapote (Casimiroa spp.), and other cultivars and/or hybrids 

of these: MSA= 0.125; MYA= 0.446 (0.448?); 7-d; S or F; G/A/C; PHI= 7 d (up to 0.446) 6 FDC

Non-bearing citrus trees: MSA= 0.125; MYA= 0.445; 7-d; F; AirBlast 7 FDC

Non-bearing citrus trees: MSA= 0.125; MYA= 0.445; 7-d; F; AirBlast 9 FDC

Non-bearing citrus trees: MSA= 0.224; MYA= 0.446; 7-d; F; AirBlast 10 FDC

Cotton and 

Cotton Seed 

Subgroup 

(20c)

Includes cultivars, varieties and other hybrids of these: FDC: MSA= 0.223 (one appl. Foliar); 

S or F; G/A/C/; PHI= 30 d and NPC: MSA= 0.223 (one appl. Foliar); For application refer 

to note 1; PHI= 30 d 2

FDC +

NPC

Cotton: FDC: MSA= 0.222; MYA= 0.444; 7-d; S or F; G/A/C; PHI= 30 d 5 FDC

Cucurbit 

Vegetables

Chayote (fruit), Chinese waxgourd (Chinese preserving melon), Citron melon, Cucumber, 

Gherkin, Gourd (edible, includes hyotan, cucuzza, hechima, Chinese okra), Momordica spp. 

(includes balsam apple, balsam pear, bitter melon, Chinese cucumber), Muskmelon (hybrids 

and/or cultivars of Cucumis melo including true cantaloupe, cantaloupe, casaba, Crenshaw 

melon, golden pershaw melon, honeydew melon, honey balls, mango melon, Persian melon, 

pineapple melon, Santa Claus melon, snake melon), Pumpkin, Squash (includes summer squash 

types such as: crookneck squash, scallop squash, straightneck squash, vegetable marrow, 

zucchini, and winter squash types such as acorn squash, butternut squash, calabaza, Hubbard 

squash, spaghetti squash), Watermelon (includes hybrids and/or varieties of Citrullus lanatus): 

FDC: MSA= 0.223; MYA= 0.446; 5-d; S or F; G/A/C/D; PHI= 0 d

And NPC: MSA= 0.223; MYA= 0.446; 5-d; For application refer to Note 1; PHI= 0 d 2

FDC + 

NPC

Chayote (fruit); Chinese waxgourd (Chinese preserving melon); citron melon; cucumber; 

gherkin; edible gourd (includes hyotan, cucuzza, hechima, Chinese okra); Momordica spp 

(includes balsam apple, balsam pear, bitter melon, Chinese cucumber); muskmelon (includes 

cantaloupe); pumpkin; squash (summer and

winter, includes butternut squash, calabaza, hubbard squash, acorn squash, spaghetti squash); 

watermelon: FDC: MSA= 0.178; MYA= 0.446 (one soil Appl. + two foliar); 5-d; S or F; 

G/A/C/ D; PHI= 7 d 3 FDC

All crops listed for product 3 above (CG 9): FDC: MSA= 0.222; MYA= 0.444; 10-d; S or F; 

G/A/C; PHI= 7 d 5 FDC

All crops listed for product 3 above

MSA= 0.125; MYA= 0.446 (0.448?); 7-d; S or F; G/A/C; PHI= 0 d (up to 0.446) 6

FDC 

+ FDS

Note 1: Varies by crop: applied chemical is to reach the root zone by irrigating-in, drench, and chemigation or in 

seed-furrow
30

Table I-4 Fruiting vegetables, Ginseng Grapes and small vine fruits (refer to Abbreviations, above)

CR or GC Crops Product Purpose

Fruiting 

Vegetables

African eggplant, Bush tomato, Cocona, Currant tomato, Eggplant, Garden huckleberry, Goji 

berry, Groundcherry, Martynia, Naranjilla, Okra, Pea eggplant, Pepino, Pepper (Capsicum 

spp., including Bell, Chili, Cooking, Pimento and Sweet), Roselle, Scarlet eggplant, 

Sunberry, Tomatillo, Tomato, Tree tomato, and cultivars, varieties, and/or hybrids of these

FDC: MSA= 0.233; MYA= 0.446; 5-d; S or F; G/A/C/D; PHI= 0 d

NPC: MSA= 0.233; MYA= 0.446; 5-d; For application refer to Note 1; PHI= 0 d 2

FDC 

+ 

NPC

Tomato

MSA= 0.091; MYA= 0.444; 7-d; S or F; G/A/C; PHI= 1 d 4 FDC

Okra

MSA= 0.167; MYA= 0.444; 14-d; S or F; G/A/C; PHI= 3 d 5 FDC

All crops listed for product 1 above (CG 8)

MSA= 0.222; MYA= 0.444; 7-d; S or F; G/A/C; PHI= 7 d 5 FDC

Eggplant, Groundcherry, Okra, Pepinos, Pepper (Capsicum spp., including bell, chili, 

cooking, pimento and sweet), Tomatillo, Tomato.

MSA= 0.125; MYA= 0.446 (0.448?); 7-d; S or F; G/A/C; PHI= 3 d (up to 0.446) 6

FDC 

+ FDS

Ginseng

Ginseng

MSA= 0.223; MYA= 0.446; 5-d; S or F; G/A/C; PHI= 7 d 2 FDC

Ginseng

MSA= 0.220; MYA= 0444; 7-d; S or F; G/A/C; PHI= 30 d 4 FDC

Ginseng

MSA= 0.125; MYA= 0.251; 7-d; S or F; G/A/C; PHI= 7 6 FDC

Grapes and 

small vine 

fruits (except 

fuzzy 

kiwifruit)

Amur river grape, Gooseberry, Grape, Kiwifruit, Hardy, Maypop, Schisandra berry, and 

cultivars, varieties, and/or hybrids of these

FDC: MSA= 0.223; MYA= 0.446; 12-d; S or F; G/A/C/D; PHI= 7 d

NPC: MSA= 0.223; MYA= 0.446; 12-d; For application refer to note 1; PHI= 7 d 2

FDC

+ FDS 

+ 

NPC

Non-bearing grapes:

MSA= 0.221; MYA= 0.446; 12-d; F; AirBlast Drip 1 FDC

Same crops listed for product 1

MSA= 0.220; MYA= 0.444; 12-d; S or F; G/A/C; PHI= 7 d 4 FDC

Same crops listed for product 1

MSA= 0.112; MYA= 0.444; 12-d; S or F; G/A/C; PHI= 14 d 5

FDC 

+ FDS

Same crops listed for product 1 except (concord grapes)

MSA= 0.125; MYA= 0.446 (0.448?); 7-d; S or F; G/A/C; PHI= 14 d (up to 0.446) up to 6 

applications lowest single application= 0.066 6

FDC 

+ FDS

Non-bearing grapes: MSA= 0.125; MYA= Maximum 6 applications Assumed= 0.446 as it 

is not specified (minimum= 0.049); 12-d; F; AirBlast 7 FDC

Non-bearing grapes: MSA= 0.125; MYA= 6 applications Assumed= 0.446 as it is not 

specified (minimum= 0.049); 12-d; F; AirBlast 9 FDC

Non-bearing grapes: MSA= 0.224; MYA= 0.446; 12-d; F; AirBlast 10 FDC

Note 1: Varies by crop: applied chemical is to reach the root zone by irrigating-in, drench, and chemigation or in 

seed-furrow
31

Table I-5 Grasses, Herbs, and Hops, Leafy green/petiole vegetables (refer to Abbreviations, above)

CR or GC Crops Product Purpose

Grasses for 

forage/feed 

(including 

grasses grown 

for seed)

Grass forage, fodder, or hay: Any grass (Gramineae family) except sugarcane that will be fed 

to or grazed by livestock, all pasture and range grasses and grasses grown for hay or silage

MSA= 0.223; MYA= 0.446; 14-d; S or F; G/A/C; PHI= 7 d 2 FDC

Same crops listed for product 1

MSA= 0.222; MYA= 0.444; 14-d; S or F; G/A/C; PHI= 7 d 5 FDC

Same crops listed for product 1

MSA= 0.125; MYA= 0.251; 14-d; S or F; G/A/C; PHI= 7 6 FDC

Herbs and 

Spices (except 

black pepper)

Allspice, Angelica, Anise (anise seed), Anise (star), Annatto (seed), Balm (lemon balm), 

Basil (fresh and dried), Borage, Bumet, Camomile, Caper buds, Caraway, Caraway (black), 

Cardamom, Cassia (bark and buds), Catnip, Celery seed, Chervil (dried), Chinese chive, 

Chive, Cinnamon, Clary, Clove (buds),

Coriander (cilantro or Chinese parsley leaves, Coriander seed (cilantro seed), Costmary, 

Culantro (leaf and seed), Cumin, Curry leaf, Dill (seed), Dillweed, Fennel [common and 

Florence (seed)], Fenugreek, Grains of paradise, Horehound, Hyssop, Juniper berry, 

Lavender, Lemongrass, Lovage (leaf and seed), Mace, Marigold, Marjoram, Mustard (seed), 

Nasturtium, Nutmeg, Parsley (dried), Pennyroyal, Poppy (seed), Rosemary, Rue, Saffron, 

Sage, Savory (summer and winter), Sweet bay (bay leaf), Tansy, Tarragon,

Thyme, Vanilla, Wintergreen, Woodruff, Wormwood.

MSA= 0.223; MYA= 0.446; 7-d; S or F; G/A/C/D; PHI= 0 d 2

FDC 

+ FDS

Same crops listed for product 1

MSA= 0.125; MYA= 0.251; 14-d; S or F; G/A/C; PHI= 7 6 FDC

Hops

Hops: MSA= 0.223; MYA= 0.446; 14-d; S or F; G/A/C/D; PHI= 7 d 2 FDC

Hops: MSA= 0.222; MYA= 0.444; 14-d; S or F; G/A/C; PHI= 14 d 5

FDC 

+ 

FDS

Hops

MSA= 0.125; MYA= 0.446 (0.448?); 14-d; S or F; G; PHI= 14 d (up to 0.446) up to 4 

applications Min 0.049 6

FDC 

+ FDS

Leafy Green 

Vegetables**

Amaranth (Leafy amaranth, Chinese spinach, Tampala), Arugula (Roquette), Cardoon, 

Celery, Celtuce, Chervil, Chinese celery, Chrysanthemum (Edible-leaved and Garland), 

Cilantro, Corn salad, Cress (Garden), Cress (Upland, Yellow rocket, Winter cress), 

Dandelion, Dock (Sorrel), Endive (Escarole), Florence fennel (Sweet anise, Sweet fennel, 

Finocchio), Lettuce (Head and Leaf), Orach, Parsley, Purslane (Garden and Winter), 

Radicchio (Red chicory), Rhubarb, Spinach [including New Zealand and vine (Malabar 

spinach, Indian spinach)], Swiss chard, Watercress

MSA= 0.223; MYA= 0.446; 7-d; S or F; G/A/C/D; PHI= 0 d 2 FDC

Same crops listed for product 1

MSA= 0.125; MYA= 0.251; 14-d; S or F; G/A/C; PHI= 7 6

FDC 

+ 

FDS

Leafy Petiole 

Vegetables

Cardoon, Celery, Celtuce, Chinese celery, Florence fennel (including, sweet anise, sweet 

fennel, Finocchio), Rhubarb, Swiss chard

MSA= 0.095; MYA= 0.251; 14-d; S or F; G/A/C/D; PHI= 7 d 6

FDC 

+ FDS
32

Table I-6 Legumes and Ornamentals (refer to Abbreviations, above) 

CR or GC Crops Product Purpose

Legume 

Vegetables 

(including 

soybean)

Crops: Edible Podded and Succulent Shelled Pea and Bean and Dried Shelled Pea and Bean, 

Bean (Lupinus spp., includes Grain lupin, Sweet lupin, White lupin, and White sweet lupin), 

Bean (Phaseolus spp., includes Field bean, Kidney bean, Lima bean, Navy bean, Pinto bean, 

Runner bean, Snap bean, Tepary bean, Wax bean), Bean (Vigna spp., includes Adzuki bean, 

Asparagus bean, Blackeyed pea, Catjang, Chinese longbean, Cowpea, Crowder pea, Moth 

bean, Mung bean, Rice bean, Southern pea, Urd bean, Yardlong bean), Pea (Pisum spp., 

includes Dwarf pea, Edible pea, Edible-pod pea, English pea, Field pea, Garden pea, Green 

pea, Snow pea, Sugar snap pea), Other Beans and Peas [Broad bean (Fava), Chickpea 

(Garbanzo bean), Guar, Jackbean, Lablab bean (Hyacinth bean), Lentil, Pigeon pea, Soybean, 

Soybean (immature seed), Sword bean

Plus: plant parts of any legume that will be used as animal feed

FDC: MSA= 0.2230; MYA= 0.446; 7-d; S or F; G/A/C; PHI= 0 d

NPC: MSA= 0.223; one application; For application refer to Note 1; PHI= 0 d 2

FDC 

+

NPC

Soybean crop only

MSA= 0.134; MYA= 0.403; 10-d; S or F; G/A/C; PHI= 21 d 3 FDC

Soybean crop only

MSA= 0.112; MYA= 0.337; 10-d; S or F; G/A/C; PHI= 21 d 5

FDC 

+ FDS

Soybean crop only

MSA= 0.125; MYA= 0.251; 10-d; S or F; G/A/C; PHI= 21 d 6

FDC 

+ FDS

Ornamentals

Ornamentals (foliar or flower Diseases) in residential and commercial landscapes, 

interiorscapes, field grown and container ornamentals in nurseries and greenhouses, lath 

houses, shade houses, containers and other enclosed structures. Restricted for application to 

non-bearing fruit trees G (foliar)

1 FDC

Ornamentals (for all listed ornamentals)

MSA= 0.221; MYA= 0.446; 5-d; F or Drench; G/C

Ornamental sunflower: MSA= 0.221; MYA= 0.446; 14-d; F; G/C

Spot Treatment: Same as Turf (will be low rate compared to total treatment)

Ornamentals (foliar or stem, root and Damping off of New Seedlings Diseases) in 

ornamentals listed above for product 2

MSA= 0.130; MYA= 0.445 for plants grown in outdoor nurseries, outdoor seedbeds, field 

plantings, and landscapes and 0.130 for foliar application; 7-d; F or Drench; G 7 FDC

Ornamentals (foliar or stem, root and Damping off of New Seedlings Diseases) in 

ornamentals listed above for product 2

MSA= 0.131; MYA= 0.445 for plants grown in outdoor nurseries, outdoor seedbeds, field 

plantings, and landscapes and 0.131 for foliar application; 7-d; F or Drench; G 9 FDC

Ornamental sunflower: MSA= 0.224; MYA= 0.446; 7-d; F; G 10 FDC

Ornamentals: MSA= 0.223 (30-d) Or one application 0.446; Apply by soil Drench 10 NPC

Spot Treatment Same as Turf (will be low rate compared to total treatment) 10

FDC 

+ 

NPC

Ornamentals: MSA= 0.223 (30-d) Or one application 0.446; Apply by soil Drench 11 NPC

Spot Treatment Same as Turf (will be low rate compared to total treatment) 11 NPC

Note 1: Varies by crop: applied chemical is to reach the root zone by irrigating-in, drench, and chemigation or in 

seed-furrow
33

Table I-7 Peanuts, Pome Fruits, and Potato and Other Tuberous, and Corm Vegetables (refer to 

Abbreviations, above)

CR or GC Crops Product Purpose

Peanuts

Peanuts crop

FDC: MSA= 0.223; MYA= 0.446; 14-d; S or F; G/A/C; PHI= 7 d

NPC: MSA= 0.223; one application; For application refer to Note 1 2

FDC +

NPC

Peanuts Seed Treatment

One application at 0.284 lb a.i/A 2

FDC + 

NPC

Peanut crop

MSA= 0.178; MYA= 0.446; 14-d; S or F; G/A/C; PHI= 14 d (up to 0.446 w/other) 3 FDC

Peanut crop

MSA= 0.205; MYA= 0.444; 14-d; S or F; G/A/C; PHI= 14 d 5

FDC + 

FDS

Peanut crop

MSA= 0.115; MYA= 0.446 (0.448); 14-d; S or F; G/A/C; PHI= 14 d 6

FDC + 

FDS

Pome Fruits

Apple, Azarole, Crabapple, Loquat, Mayhaw, Medlar, Pear, Pear (Asian), Quince, Quince 

(Chinese and Japanese), Tejocote, and cultivars, varieties, and/or hybrids of these

MSA= 0223; MYA= 0.446; 7-d; S or F; G/A/C/D; PHI= 7 d 2

FDC + 

FDS

None bearing: MSA= 0.221; MYA= 0.446; 7-d; F; AirBlast Drip 1 FDC

CG 11: Apple, Crabapple, Loquat, Mayhaw, Pear, Oriental pear, Quince 

MSA= 0.130; MYA= 0.444; 7-d; S or F; G/AB/C; PHI= 72 d 4 FDC

CG 11: Apple, Crabapple, Loquat, Mayhaw, Pear, Oriental pear, Quince 

MSA= 0.131; MYA= 0.444; 10-d; S or F; G/AB/C; PHI= 75 d 5

FDC + 

FDS

Crops listed for product 4: MSA= 0.095; MYA= 0.345; 7-d; S or F; G/A/C/D; PHI= 14 d; 

not more than 4 applications Min application= 0.082 6 FDC

None bearing: MSA= 0.095; MYA= 0.345; 7-d; F; AirBlast 7 FDC

None bearing: MSA= 0.095; MYA= 0.345; 7-d; F; AirBlast 9 FDC

Non-bearing trees: MSA= 0.224; MYA= 0.446; 7-d; F; AirBlast 10 FDC

Potato and 

Other 

Tuberous, 

and Corm 

Vegetables

Arracacha, Arrowroot, Artichoke (Chinese and Jerusalem), Canna (Edible), Cassava (Bitter 

& Sweet), Chayote (root), Chufa, Dasheen, Ginger, Leren, Potato, Sweet potato, Tanier 

(Cocoyam), Turmeric, Yam bean (Jicama, Manoic pea), Yam (True)

FDC: MSA= 0.223; MYA= 0.446; 5-d; S or F; G/A/C; PHI= 7 d

NPC: MSA= 0.223; one application; For application refer to Note 1 2

FDC + 

FDS + 

NPC

Same crops above

MSA= 0.091; MYA= 0.444; 7-d; S or F; G/A/C; PHI= 7 d 4 FDC

Arracacha, Arrowroot, Artichoke (Chinese and Jerusalem), Beet (garden), Burdock (edible), 

Canna (edible, Queensland arrowroot), Cassava (bitter & sweet), Celeriac (celery root), 

Chayote (root), Chervil (turnip-rooted), Chicory, Chufa, Dasheen (taro), Ginger, Horseradish, 

Leren, Parsley (turnip-rooted), Parsnip, Potato, Radish, Oriental radish (daikon), Rutabaga, 

Salsify (black), Salsify (oyster plant), Salsify

(Spanish), Skirret, Sweet potato, Tanier (cocoyam), Turmeric, Turnip, Yam bean (jicama, 

Manoic pea), Yam (true). (See separate use directions for Artichoke (globe), Carrot, 

Ginseng, and Sugarbeet)

MSA= 0.095; MYA= 0.377; 14-d; S or F; G/A/C; PHI= 7 d; No more than 4 applications 

noting that the minimum rate= 0.082 6

FDC + 

FDS

Note 1: Varies by crop: applied chemical is to reach the root zone by irrigating-in, drench, and chemigation or in 

seed-furrow
34

Table I-8 Small berries and Stone fruits (refer to Abbreviations, above)

CR or GC Crops Product Purpose

Small Berries

Blackberry Rubus spp., (including Andean Blackberry, Artic blackberry, Bingleberry, Black 

satin berry, Boysenberry, Brombeere, California blackberry, Chesterberry, Cherokee 

blackberry, Cheyenne blackberry, Common blackberry, Coryberry, Darrowberry, Dewberry, 

Dirksen thornless berry, Evergreen blackberry, Himalayaberry, Hullberry, Lavacaberry, 

Loganberry, Lowberry, Lucretiaberry, Mammoth blackberry, Marionberry, Mora, Mures 

deronce, Nectarberry, Northern

dewberry, Olallieberry, Oregon evergreen berry, Phenomenalberry, Rangeberry, Ravenberry, 

Rossberry, Shawnee blackberry, Southern dewberry, Tayberry, Youngberry, Zarzamora, and 

cultivars, varieries, and/or hybrids of these.

Raspberry Rubus spp. (Rubus occidentalis, Rubus strigosus, Rubus idaeus) (including 

Bababerry, Black raspberry, Blackcap, Framboise, Frambueso, Himbeere, Keriberry, 

Mayberry, Purple raspberry, Red raspberry, Thimbleberry, Tulameen, Wild raspberries, 

Yellow raspberry) and cultivars, varieties, and/or hybrids of these.

MSA= 0.223; MYA= 0.453; 7-d; S or F; G/A/C/D; PHI= 0 d 2

FDC 

+ FDS

Bushberry (Aronia), Blueberry (Highbush and lowbush), Currant (Buffalo), Guava 

(Chilean), Currant (Black and Red), Barberry (European), Elderberry, Gooseberry, Cranberry 

(highbush), Honeysuckle, Huckleberry, Jostaberry, Juneberry, Currant (Native), Salal, Sea 

buckthorn and cultivars, varieties, and/or hybrids of these

MSA= 0.178; MYA= 0.356; 7-d; F; G/C; PHI= 7 d (up to 0.446 w/other) 3 FDC

Blackberry, Raspberry and Bushberry 0.220-0.445/7-d G/A/AB/C

MSA= 0.220 ; MYA= 0.444; 7-d; S or F; G/A/C; PHI= 0 d 4 FDC

Stone Fruits

Apricot, Apricot (Japanese), Capulin, Cherry (Black, Nanking, Sweet, Tart), Jujube 

(Chinese), Nectarine, Peach, Plum, Plum (American, Beach, Canada, Cherry, Chickasaw, 

Damson, Japanese, Klamath), Prune, Plumcot, Sloe, and cultivars, varieties, and/or hybrids of 

these

MSA= 0.223; MYA= 0.445; 5-d; S or F; G/A/C/D; PHI= 0 d 2 FDC

None bearing drip or sprat early bloom depending on the disease

MSA= 0.221; MYA= 0.446; 5-d; F; AirBlast Drip 1 FDC

Apricot, Nectarine, Peach, Plum (all varieties including Chickasaw, Damson, Japanese, and 

Stanley), Plumcot, Prune (fresh and dried) 

MSA= 0.220; MYA= 0.444; 7-d; S or F; G/AB/C; PHI= 30 d 4

FDC 

+ FDS

Crop Group 12: Apricot, Cherry (sweet and tart), Nectarine, Peach, Plum (all varieties 

including Chickasaw, Damson, Japanese, and Stanley), Plumcot, Prune (fresh and dried).

MSA= 0.131; MYA= 0.444; 7-d; S or F; G/AB/C; PHI= 0 d 5 FDC

Apricot, Cherry (sweet and tart), Nectarine, Peach, Plum (including Chickasaw, Damson and 

Japanese), Plumcot, Prune (fresh and dried).

MSA= 0.125; MYA= 0.446 (0.448?); 7-d; S or F; G/A/C; PHI= 1 d No more than 4 

application Min application rate= 0.082 6 FDC

None bearing

MSA= 0.125; MYA= 0.251 not more than 4 applications (minimum application 0.082); 

7-d; F; AirBlast 7 FDC

None bearing

MSA= 0.125; MYA= 0.251; 7-d; F; AirBlast 9 FDC

Non-bearing trees

MSA= 0.224; MYA= 0.446; 5-d; F; AirBlast 10 FDC
35

Table I-9 Strawberry, Sugar beet, and Sunflower (refer to Abbreviations, above)

CR or GC Crops Product Purpose

Strawberry 

and Other 

Low-growing 

Berries

Bearberry, Bilberry, Blueberry (Low-bush), Cloudberry, Cranberry, Lingonberry, Muntries, 

Partridgeberry, Strawberry

FDC: MSA= 0.223; MYA= 0.446; 7-d; 7-d; S or F; G/A/C/D; PHI= 0 d

NPC: MSA= 0.223; MYA= 0.446; 7-d; For application refer to Note 1; PHI= 0 d 2

FDC 

+NPC

All of the above except strawberry

MSA= 0.135; MYA= 0.313; 7-d; F; G/C; PHI= 45 d (up to 0.446 w/other) 3 FDC

Bearberry, Bilberry, Blueberry (Low-bush), Cloudberry, Cranberry, Ligonberry, Muntries, 

Partridgeberry, Strawberry

MSA= 0.220; MYA= 0444; 7-d; S or F; G/A/C; PHI= 1 d 4

FDC + 

FDS

Crops the same as listed for product 4, above

MSA= 0.125; MYA= 0.446 (27.3=0.448? should be 27.2=0.446); 7-d; S or F; G/A/C; 

PHI= 0 d Min application rate= 0.067 6

FDC + 

FDS

Sugar beet

Sugar beet

MSA= 0.223; MYA= 0.453; 5-d; F; G/A/C; PHI= 7 d 2 FDC

Sugar beet

MSA= 0.178; MYA= 0.446; 14-d; S or F; G/A/C; PHI= 7 d 3 FDC

Sugar beet

MSA= 0.125; MYA= 0.330; 10-d; S or F; G/A/C; PHI= 21 d 6 FDC

Sunflower 

Subgroup

Calendula, castor oil plant, Chinese tallowtree, euphorbia, evening primrose, jojoba, niger 

seed, rose hip, safflower, stokes aster, sunflower, tallowwood, tea oil plant, vernonia, 

cultivars, varieties, and/or

hybrids of these

MSA= 0.223; MYA= 0.446; 14-d; S or F; G/A/C; PHI= 14 d 2 FDC

Sunflower: MSA= 0.167; MYA= 0.444; 14-d; S or F; G/A/C; PHI= 50 d 5 FDC

Note 1: Varies by crop: applied chemical is to reach the root zone by irrigating-in, drench, and chemigation or in 

seed-furrow
36

Table I-10 Tree nuts (refer to Abbreviations, above)

CR or GC Crops Product Purpose

Tree 

Nuts

African nut-tree, Almond, Beechnut, Brazil nut, Brazilian pine, Bunya, Bur oak, Butternut, Cajou 

nut, Candlenut, Cashew, Chestnut, Chinquapin, Coconut, Coquito nut, Dika nut, Ginkgo, Guiana 

chestnut, Hazelnut (Filbert), Heartnut, Hickory nut, Japanese horse-chestnut, Macadamia nut (bush 

nut), Mongongo nut, Monkey-pot, Monkey puzzle nut, Okari nut, Pachira nut, Peach palm nut, 

Pecan, Pequi, Pili nut, Pine nut, Pistachio, Sapucaia nut, Tropical almond, Walnut [including Black 

and

English (Persian) walnuts], Yellowhorn, and cultivars, varieties, and/or hybrids of these

MSA= 0.223; MYA= 0.446; 7-d; S or F; G/A/C/D; PHI= 7 d 2 FDC

Almonds MSA= 0.220; MYA= 0.444; 7-d; S or F; G/A/AB/C; PHI= 30 d 4

FDC

+ 

FDS

Pistachio MSA= 0.220; MYA= 0.444; 7-d; S or F; G/A/AB/C; PHI= 30 d 4 FDC

Crop Group 14 (See separate use directions for: Almonds, Pecan, and Pistachio): Beech nut, 

Brazil nut, Butternut, Cashew, Chestnut, Chinquapin, Filbert (hazelnut), Hickory nut, Macadamia nut 

(bush nut), Walnut [including black and English (Persian) walnuts]

MSA= 0.222; MYA= 0.444; 7-d; S or F; G/A/AB/C; PHI= 35 d 5

FDC

+ 

FDS

Pecans MSA= 0.220; MYA= 0.444; 14-d; S or F; G/A/AB/C; PHI= shucks begin to split 5 FDC

Pistachio MSA= 0.220; MYA= 0.444; 10-d; S or F; G/A/AB/C; PHI= 35 d 5 FDC

Almonds MSA= 0.220; MYA= 0.444; 7-d; S or F; G/A/AB/C; PHI= 35 d 5

FDC

+ 

FDS

Almonds MSA= 0.125; MYA= 0.446 (0.448?); 7-d; S or F; G/A/AB/C; PHI= 14 d 6 FDC

Pecans MSA= 0.125; MYA= 0.446 (0.448?); 14-d; S or F; G/A/AB/C; PHI= 30

Maximum 6 applications Min application= 0.067 6 FDC

Pistachio MSA= 0.125; MYA= 0.377; 14-d; S or F; G/A/AB/C; PHI= 28 d 6 FDC

(See separate use directions for: Almonds, Pecan, and Pistachio):

Beech nut, Brazil nut, Butternut, Cashew, Chestnut, Chinquapin, Filbert (hazelnut), Hickory nut, 

Macadamia nut (bush nut), Walnut [including black and English (Persian) walnuts]. 

MSA= 0.125; MYA= 0.446 (0.448?); 7-d; S or F; G/A/AB/C; PHI= 60 d 6 FDC

Non-bearing tree nuts

MSA= 0.125; MYA= 0.251 not more than 4 applications (minimum application= 0.082; 7-d; F; 

AirBlast 7 FDC

Non-bearing tree nuts

MSA= 0.125; MYA= 0.251 not more than 4 applications (minimum application= 0.082; 7-d; F; 

AirBlast 9 FDC
37
38

Table I-11 Turf (refer to Abbreviations, above)

CR or GC Crops Product Purpose

Turf

Areas: Turf on golf courses, sod farms, sport fields, residential, institutional, municipal, commercial, 

and other turf grass areas

Grass types:

 All cool season turf grasses such as Bent grasses, Bluegrasses, Fescues, Ryegrasses, including 

mixtures thereof;

 All warm season grasses such as Bermudagrass, St Augustine grass, Seashore paspalum, Kikuyu 

grass, and Zoysia grass

FDC: MSA= 0.226; MYA= 0.446; 7-14-d (for low/high rates); F; G/C

NPC: MSA= 0.226; MYA= 0.446; 14-d; Or one application at 0.453; For application refer to note 

2

1

FDC + 

NPC

Spot treatment: Use maximum rates

FDC: MSA= 5.20 E-6/sq ft (5.20 E-2/Acre) Four Appl./= MYA= 0.208; 14-d; F; G/C

NPC: MSA= 1.04 E-5/sq ft (Four Appl./= MYA= 0.416; 14-d; For application refer to Note 2

Turf as specified for product 2, above

FDC: MSA= 0.212- 0.446; MYA= 0.446; 7-14 d (for low/high rates); F; G

NPC: MSA= 0.212; MYA= 0.446; 14 d; Or one application at 0.446; For application refer to Note 

2 7

FDC 

+ 

NPC

Turf as specified for product 2, above

FDC: MSA= 0.212- 0.446; MYA= 0.446; 7-14 d (for low/high rates); F; G

NPC: MSA= 0.212; MYA= 0.446; 14 d; Or one application at 0.446; For application refer to Note 

2 8

FDC 

+ 

NPS

Spot treatment: 4 times the highest rate for 10,00 sq. ft instead of 1,000 sq ft 8

FDC 

+ 

NPC

Turf as specified for product 2, above

FDC: MSA= 0.214- 0.429; MYA= 0.445; 7-10-14 d (for low/high rates); F; G

NPC: MSA= 0.214-0.429; MYA= 0.445; 14- d; For application refer to Note 2 9

FDC 

+ 

NPC

Turf as specified for product 2, above

FDC: MSA= 0.057- 0.227; MYA= 0.446; 7-14 d (for low/high rates); F; G/Drench

NPC: MSA= 0.227-0.455; MYA= 0.446; 14- d; For application refer to Note 2 10

FDC 

+ 

NPC

Spot treatment: 4 times the highest rate for 10,00 sq. ft instead of 1,000 sq ft 10

FDC 

+ 

NPC

Turf as specified for product 2, above

MSA= 0.227-0.455; MYA= 0.446; 14- d; Appli. For application refer to Note 2 11 NPC

Spot treatment: 4 times the highest rate for 10,00 sq. ft instead of 1,000 sq ft 11 NPC

Note 2: Irrigate-in to the root zone

Appendix 2: 

Freshwater 

Fish

Freshwater 

Invertebrates

Freshwater 

Fish

Freshwate

Invertebra
39

Crop 

Group/Crops Scenario Giving the Highest EECs

Peak 

EEC 

(μg/L)

Acute 

EC/LC50 

(μg a.i./L)

Acute 

EC/LC50 (μg 

a.i./L)

Acute RQ Acute RQ

Artichoke Artichoke 21.6 >1780 >17000 <0.01 <0.01

Beans & Peeas ILbeansNMC_+65 47.8 >1780 >17000 <0.03 <0.01

Brassica Leafy 

Vegetables CAColeCropRLF_V2_+65 37.3 >1780 >17000 <0.02 <0.01

Bulb Vegetables GAOnion_WirrigSTD_+210 23.6 >1780 >17000 <0.01 <0.01

Canola NDcanolaSTD_+95 31.5 >1780 >17000 <0.02 <0.01

Carrot FLcarrotSTD_+0 40.2 >1780 >17000 <0.02 <0.01

Cereals: Corn 

and Sorghum

MScornSTD_+135 & 

KSCornStd_+160 50.1 >1780 >17000 <0.03 <0.01

Cereals: Wheat 

& others TXwheatOP_+235 51.3 >1780 >17000 <0.03 <0.01

Christmas Trees Christmas Trees 6.94 >1780 >17000 <0.01 <0.01

Citrus FLcitrusSTD_+145 20.6 >1780 >17000 <0.01 <0.01

Cotton STXcottonNMC_+160 & 

NCcottonSTD_+75 31.7 >1780 >17000 <0.02 <0.01

Cucurbits STXmelonNMC_+9 & 

FLcucumberSTD_+0 39.2 >1780 >17000 <0.02 <0.01

Fruiting 

Vegetables

STXvegetableNMC_+170 & 

FLpeppersSTD_+10 40.7 >1780 >17000 <0.02 <0.01

Ginseng MNsugarbeetSTD_+10 34.1 >1780 >17000 <0.02 <0.01

Grapes & Small 

Vine Fruits NYGrapesSTD_+90 19.6 >1780 >17000 <0.01 <0.01

Grasses for 

Forage/Seeds ORgrassseedSTD_+160 21.4 >1780 >17000 <0.01 <0.01

Herbs & Spices CAColeCropRLF_V2_+60 36.7 >1780 >17000 <0.02 <0.01

Hops ORhopsSTD_+140 24 >1780 >17000 <0.01 <0.01

Leafy 

Vegetables + 

Petiole

CAlettuceSTD_+95 40.3 >1780 >17000 <0.02 <0.01

Legume 

Vegetables 

W/Soybeans

MSsoybeanSTD_+165 37.6 >1780 >17000 <0.02 <0.01

Ornamentals: 

Residential CApervious/imperviousRLF 4.57 >1780 >17000 <0.01 <0.01
40

Ornamentals: 

Nurseries MInurserySTD_V2_+230 29.6 >1780 >17000 <0.02 <0.01

Peanut NCpeanutSTD_+140 32.4 >1780 >17000 <0.02 <0.01

Pome Fruits NCappleSTD_+35 19.3 >1780 >17000 <0.01 <0.01

Potato, 

Tuberous/Corm 

Vegies

MEpotatoSTD_+120 50.2 >1780 >17000 <0.03 <0.01

Small Berries CAWineGrapesRLF_V2_+150 13.3 >1780 >17000 <0.01 <0.01

Stone Fruits MICherriesSTD_+80 20.2 >1780 >17000 <0.01 <0.01

Strawberry CAStrawberrynonplasticRLF_V2_+5 40.7 >1780 >17000 <0.02 <0.01

Sugar beet MNsugarbeetSTD_+10 34.1 >1780 >17000 <0.02 <0.01

Sunflower CAcornOP_+140 18.1 >1780 >17000 <0.01 <0.01

Tree nuts GAPecansSTD_+75 21.2 >1780 >17000 <0.01 <0.01

Turf PAturfSTD_+60 16.5 >1780 >17000 <0.01 <0.01

Chronic FW RQs Surface Water (EECs ug/L) Freshwater 

Fish

Freshwat

er 

Invertebr

ates

Freshwat

er Fish

Freshw

Inverte

Crop 

Group/Crops

Scenario Giving 

the Highest EECs 21-day 60-day Chronic Chronic Chronic Chro

Artichoke Artichoke 21.3 21.0 135 1240 0.16 0.0

Beans & Peeas ILbeansNMC_+65 47.0 46.2 135 1240 0.34 0.0

Brassica Leafy 

Vegetables

CAColeCropRLF_

V2_+65 36.7 36.0 135 1240 0.27 0.0

Bulb Vegetables GAOnion_WirrigS

TD_+210 23.2 22.9 135 1240 0.17 0.0

Canola NDcanolaSTD_+95 31.1 30.9 135 1240 0.23 0.0

Carrot FLcarrotSTD_+0 38.3 36.4 135 1240 0.27 0.0

Cereals: Corn and 

Sorghum

MScornSTD_+135 

& 

KSCornStd_+160 

49.3 48.2 135 1240 0.36 0.0

Cereals: Wheat & 

others TXwheatOP_+235 49.9 48.9 135 1240 0.36 0.0

Christmas Trees Christmas Trees 6.8 6.7 135 1240 0.05 0.0

Citrus FLcitrusSTD_+145 20.2 19.4 135 1240 0.14 0.0

Cotton

STXcottonNMC_+1

60 & 

NCcottonSTD_+75 

30.7 30.5 135 1240 0.23 0.0
41

Cucurbits

STXmelonNMC_+9 

& 

FLcucumberSTD_

+0 

38.2 36.2 135 1240 0.27 0.0

Fruiting Vegetables

STXvegetableNMC

_+170 & 

FLpeppersSTD_+1

0 

39.6 38.6 135 1240 0.29 0.0

Ginseng MNsugarbeetSTD_

+10 33.7 33.3 135 1240 0.25 0.0

Grapes & Small 

Vine Fruits

NYGrapesSTD_+9

0 19.4 19.2 135 1240 0.14 0.0

Grasses for 

Forage/Seeds

ORgrassseedSTD_

+160 21.0 20.6 135 1240 0.15 0.0

Herbs & Spices CAColeCropRLF_

V2_+60 36.2 35.6 135 1240 0.26 0.0

Hops ORhopsSTD_+140 23.7 23.5 135 1240 0.17 0.0

Leafy Vegetables + 

Petiole CAlettuceSTD_+95 39.8 39.2 135 1240 0.29 0.0

Legume Vegetables 

W/Soybeans

MSsoybeanSTD_+

165 37.2 37.1 135 1240 0.27 0.0

Ornamentals: 

Residential

CApervious/imperv

iousRLF 4.5 4.4 135 1240 0.03 0.0

Ornamentals: 

Nurseries

MInurserySTD_V2

_+230 29.3 29.4 135 1240 0.22 0.0

Peanut NCpeanutSTD_+14

0 32.0 31.6 135 1240 0.23 0.0

Pome Fruits NCappleSTD_+35 18.4 17.2 135 1240 0.13 0.0

Potato, 

Tuberous/Corm 

Vegies

MEpotatoSTD_+12

0 49.9 49.6 135 1240 0.37 0.0

Small Berries CAWineGrapesRL

F_V2_+150 13.4 13.1 135 1240 0.10 0.0

Stone Fruits MICherriesSTD_+

80 20.0 19.7 135 1240 0.15 0.0

Strawberry CAStrawberrynonp

lasticRLF_V2_+5 40.0 39.1 135 1240 0.29 0.0

Sugar beet MNsugarbeetSTD_

+10 33.7 33.3 135 1240 0.25 0.0

Sunflower CAcornOP_+140 17.8 17.6 135 1240 0.13 0.0

Tree nuts GAPecansSTD_+7

5 21.2 21.3 135 1240 0.16 0.0

Turf PAturfSTD_+60 16.2 15.8 135 1240 0.12 0.0
42

Crop Group/Crops Scenario Giving the Highest EECs

Peak 

EEC 

(ug 

a.i./L)

Saltwater 

Invertebrates 

EC/LC50 (ug 

a.i./L)

Saltwater 

Invertebrates 

Acute RQs*

Artichoke Artichoke 21.6 510 0.04

Beans & Peeas ILbeansNMC_+65 47.8 510 0.09

Brassica Leafy Vegetables CAColeCropRLF_V2_+65 37.3 510 0.07

Bulb Vegetables GAOnion_WirrigSTD_+210 23.6 510 0.05

Canola NDcanolaSTD_+95 31.5 510 0.06

Carrot FLcarrotSTD_+0 40.2 510 0.08

Cereals: Corn and Sorghum MScornSTD_+135 & KSCornStd_+160 50.1 510 0.10

Cereals: Wheat & others TXwheatOP_+235 51.3 510 0.10

Christmas Trees Christmas Trees 6.9 510 0.01

Citrus FLcitrusSTD_+145 20.6 510 0.04

Cotton STXcottonNMC_+160 & 

NCcottonSTD_+75 31.7 510 0.06

Cucurbits STXmelonNMC_+9 & 

FLcucumberSTD_+0 39.2 510 0.08

Fruiting Vegetables STXvegetableNMC_+170 & 

FLpeppersSTD_+10 40.7 510 0.08

Ginseng MNsugarbeetSTD_+10 34.1 510 0.07

Grapes & Small Vine Fruits NYGrapesSTD_+90 19.6 510 0.04

Grasses for Forage/Seeds ORgrassseedSTD_+160 21.4 510 0.04

Herbs & Spices CAColeCropRLF_V2_+60 36.7 510 0.07

Hops ORhopsSTD_+140 24.0 510 0.05

Leafy Vegetables + Petiole CAlettuceSTD_+95 40.3 510 0.08

Legume Vegetables W/Soybeans MSsoybeanSTD_+165 37.6 510 0.07

Ornamentals: Residential CApervious/imperviousRLF 4.6 510 0.01

Ornamentals: Nurseries MInurserySTD_V2_+230 29.6 510 0.06

Peanut NCpeanutSTD_+140 32.4 510 0.06

Pome Fruits NCappleSTD_+35 19.3 510 0.04

Potato, Tuberous/Corm Vegies MEpotatoSTD_+120 50.2 510 0.10

Small Berries CAWineGrapesRLF_V2_+150 13.3 510 0.03

Stone Fruits MICherriesSTD_+80 20.2 510 0.04

Strawberry CAStrawberrynonplasticRLF_V2_+5 40.7 510 0.08

Sugar beet MNsugarbeetSTD_+10 34.1 510 0.07

Sunflower CAcornOP_+140 18.1 510 0.04

Tree nuts GAPecansSTD_+75 21.2 510 0.04

Turf PAturfSTD_+60 16.5 510 0.03

*All RQs are less than the value presented since the toxicity endpoint is greater than 510 ug a.i./L

Endpoints 
43

Crop Group/Crops Scenario Giving the Highest EECs

Peak 

EEC (ug 

a.i./L)

Nonvascular 

Aquatic 

Plant

Nonvascular 

Aquatic 

Plant

Nonvascu

Aquati

Plant

Acute Chronic nonliste

Artichoke Artichoke 21.6 3400 1170 0.01 

Beans & Peeas ILbeansNMC_+65 47.8 3400 1170 0.01 

Brassica Leafy Vegetables CAColeCropRLF_V2_+65 37.3 3400 1170 0.01 

Bulb Vegetables GAOnion_WirrigSTD_+210 23.6 3400 1170 0.01 

Canola NDcanolaSTD_+95 31.5 3400 1170 0.01 

Carrot FLcarrotSTD_+0 40.2 3400 1170 0.01 

Cereals: Corn and Sorghum MScornSTD_+135 & 

KSCornStd_+160 50.1 3400 1170 0.01 

Cereals: Wheat & others TXwheatOP_+235 51.3 3400 1170 0.02 

Christmas Trees Christmas Trees 6.9 3400 1170 0.00 

Citrus FLcitrusSTD_+145 20.6 3400 1170 0.01 

Cotton STXcottonNMC_+160 & 

NCcottonSTD_+75 31.7 3400 1170 0.01 

Cucurbits STXmelonNMC_+9 & 

FLcucumberSTD_+0 39.2 3400 1170 0.01 

Fruiting Vegetables STXvegetableNMC_+170 & 

FLpeppersSTD_+10 40.7 3400 1170 0.01 

Ginseng MNsugarbeetSTD_+10 34.1 3400 1170 0.01 

Grapes & Small Vine Fruits NYGrapesSTD_+90 19.6 3400 1170 0.01 

Grasses for Forage/Seeds ORgrassseedSTD_+160 21.4 3400 1170 0.01 

Herbs & Spices CAColeCropRLF_V2_+60 36.7 3400 1170 0.01 

Hops ORhopsSTD_+140 24.0 3400 1170 0.01 

Leafy Vegetables + Petiole CAlettuceSTD_+95 40.3 3400 1170 0.01 

Legume Vegetables W/Soybeans MSsoybeanSTD_+165 37.6 3400 1170 0.01 

Ornamentals: Residential CApervious/imperviousRLF 4.6 3400 1170 0.00 

Ornamentals: Nurseries MInurserySTD_V2_+230 29.6 3400 1170 0.01 

Peanut NCpeanutSTD_+140 32.4 3400 1170 0.01 

Pome Fruits NCappleSTD_+35 19.3 3400 1170 0.01 

Potato, Tuberous/Corm Vegies MEpotatoSTD_+120 50.2 3400 1170 0.01 

Small Berries CAWineGrapesRLF_V2_+150 13.3 3400 1170 0.00 

Stone Fruits MICherriesSTD_+80 20.2 3400 1170 0.01 

Strawberry CAStrawberrynonplasticRLF_V2_+5 40.7 3400 1170 0.01 

Sugar beet MNsugarbeetSTD_+10 34.1 3400 1170 0.01 

Sunflower CAcornOP_+140 18.1 3400 1170 0.01 

Tree nuts GAPecansSTD_+75 21.2 3400 1170 0.01 

Turf PAturfSTD_+60 16.5 3400 1170 0.00 

Endpoints RQs
44

Crop Group/Crops Scenario Giving the Highest EECs

Peak

EEC (ug 

a.i./L)

Vascular 

Aquatic 

Plant

Vascular 

Aquatic 

Plant

Vascular 

Aquatic 

Plant

Vascula

Aquatic 

Plant

Acute Chronic nonlisted listed

Artichoke Artichoke 21.6 2600 278 0.01 0.08

Beans & Peeas ILbeansNMC_+65 47.8 2600 278 0.02 0.17

Brassica Leafy Vegetables CAColeCropRLF_V2_+65 37.3 2600 278 0.01 0.13

Bulb Vegetables GAOnion_WirrigSTD_+210 23.6 2600 278 0.01 0.08

Canola NDcanolaSTD_+95 31.5 2600 278 0.01 0.11

Carrot FLcarrotSTD_+0 40.2 2600 278 0.02 0.14

Cereals: Corn and Sorghum MScornSTD_+135 & 

KSCornStd_+160 50.1 2600 278 0.02 0.18

Cereals: Wheat & others TXwheatOP_+235 51.3 2600 278 0.02 0.18

Christmas Trees Christmas Trees 6.9 2600 278 0.00 0.02

Citrus FLcitrusSTD_+145 20.6 2600 278 0.01 0.07

Cotton STXcottonNMC_+160 & 

NCcottonSTD_+75 31.7 2600 278 0.01 0.11

Cucurbits STXmelonNMC_+9 & 

FLcucumberSTD_+0 39.2 2600 278 0.02 0.14

Fruiting Vegetables STXvegetableNMC_+170 & 

FLpeppersSTD_+10 40.7 2600 278 0.02 0.15

Ginseng MNsugarbeetSTD_+10 34.1 2600 278 0.01 0.12

Grapes & Small Vine Fruits NYGrapesSTD_+90 19.6 2600 278 0.01 0.07

Grasses for Forage/Seeds ORgrassseedSTD_+160 21.4 2600 278 0.01 0.08

Herbs & Spices CAColeCropRLF_V2_+60 36.7 2600 278 0.01 0.13

Hops ORhopsSTD_+140 24.0 2600 278 0.01 0.09

Leafy Vegetables + Petiole CAlettuceSTD_+95 40.3 2600 278 0.02 0.14

Legume Vegetables W/Soybeans MSsoybeanSTD_+165 37.6 2600 278 0.01 0.14

Ornamentals: Residential CApervious/imperviousRLF 4.6 2600 278 0.00 0.02

Ornamentals: Nurseries MInurserySTD_V2_+230 29.6 2600 278 0.01 0.11

Peanut NCpeanutSTD_+140 32.4 2600 278 0.01 0.12

Pome Fruits NCappleSTD_+35 19.3 2600 278 0.01 0.07

Potato, Tuberous/Corm Vegies MEpotatoSTD_+120 50.2 2600 278 0.02 0.18

Small Berries CAWineGrapesRLF_V2_+150 13.3 2600 278 0.01 0.05

Stone Fruits MICherriesSTD_+80 20.2 2600 278 0.01 0.07

Strawberry CAStrawberrynonplasticRLF_V2_+5 40.7 2600 278 0.02 0.15

Sugar beet MNsugarbeetSTD_+10 34.1 2600 278 0.01 0.12

Sunflower CAcornOP_+140 18.1 2600 278 0.01 0.07

Tree nuts GAPecansSTD_+75 21.2 2600 278 0.01 0.08

Turf PAturfSTD_+60 16.5 2600 278 0.01 0.06
45

Chronic FW 

RQs

EECs 

(ug/L) Endpoints

Chronic 

Porewater 

Freshwater 

Invert

Chronic 

Porewater 

Saltwater 

Inver

Crop 

Group/Crops Scenario Giving the Highest EECs

Porewater 

FW Sed 

Invert

SW Sed 

Invert

Chronic RQ

Artichoke Artichoke 19.9 3800 7500 0.01 0.00

Beans & Peeas ILbeansNMC_+65 44.4 3800 7500 0.01 0.01

Brassica Leafy 

Vegetables CAColeCropRLF_V2_+65 34.6

3800 7500

0.01 0.00

Bulb 

Vegetables GAOnion_WirrigSTD_+210 21.5

3800 7500

0.01 0.00

Canola NDcanolaSTD_+95 30.3 3800 7500 0.01 0.00

Carrot FLcarrotSTD_+0 32.6 3800 7500 0.01 0.00

Cereals: Corn 

and Sorghum

MScornSTD_+135 & 

KSCornStd_+160 46.4

3800 7500

0.01 0.01

Cereals: Wheat 

& others TXwheatOP_+235 44.9 3800 7500 0.01 0.01

Christmas 

Trees Christmas Trees 6.4 3800 7500 0.00 0.00

Citrus FLcitrusSTD_+145 17.4 3800 7500 0.00 0.00

Cotton STXcottonNMC_+160 & 

NCcottonSTD_+75 29.8

3800 7500

0.01 0.00

Cucurbits STXmelonNMC_+9 & 

FLcucumberSTD_+0 32.5

3800 7500

0.01 0.00

Fruiting 

Vegetables

STXvegetableNMC_+170 & 

FLpeppersSTD_+10 34.8

3800 7500

0.01 0.00

Ginseng MNsugarbeetSTD_+10 

32.2 3800 7500

0.01 0.00

Grapes & Small 

Vine Fruits NYGrapesSTD_+90 19.0 3800 7500 0.01 0.00

Grasses for 

Forage/Seeds ORgrassseedSTD_+160 19.4

3800 7500

0.01 0.00

Herbs & Spices CAColeCropRLF_V2_+60 34.1

3800 7500

0.01 0.00

Hops ORhopsSTD_+140 22.9 3800 7500 0.01 0.00

Leafy 

Vegetables + 

Petiole

CAlettuceSTD_+95 38.1

3800 7500

0.01 0.01
46

Legume 

Vegetables 

W/Soybeans

MSsoybeanSTD_+165 35.4

3800 7500

0.01 0.00

Ornamentals: 

Residential CApervious/imperviousRLF

3800 7500

0.00 0.00

Ornamentals: 

Nurseries MInurserySTD_V2_+230 28.4

3800 7500

0.01 0.00

Peanut NCpeanutSTD_+140 29.8 3800 7500 0.01 0.00

Pome Fruits NCappleSTD_+35 15.4 3800 7500 0.00 0.00

Potato, 

Tuberous/Corm 

Vegies

MEpotatoSTD_+120 49.0

3800 7500

0.01 0.01

Small Berries CAWineGrapesRLF_V2_+150 12.5

3800 7500

0.00 0.00

Stone Fruits MICherriesSTD_+80 19.5 3800 7500 0.01 0.00

Strawberry CAStrawberrynonplasticRLF_V2_+5 36.3

3800 7500

0.01 0.00

Sugar beet MNsugarbeetSTD_+10 32.2

3800 7500

0.01 0.00

Sunflower CAcornOP_+140 16.9 3800 7500 0.00 0.00

Tree nuts GAPecansSTD_+75 21.1 3800 7500 0.01 0.00

Turf PAturfSTD_+60 15.6 3800 7500 0.00 0.00

Chronic FW 

RQs Endpoints

Chronic 

Sediment 

Freshwater 

Invert

Chronic 

Sediment 

Saltwater 

Inver

Crop 

Group/Crops Scenario Giving the Highest EECs

Sediment

FW Sed 

Invert

SW Sed 

Invert Chronic RQs

Artichoke Artichoke 356 26000 100000 0.01 0.00

Beans & Peeas ILbeansNMC_+65 795 26000 100000 0.03 0.01

Brassica Leafy 

Vegetables CAColeCropRLF_V2_+65 619

26000 100000 0.02 0.01

Bulb 

Vegetables GAOnion_WirrigSTD_+210 385

26000 100000 0.01 0.00

Canola NDcanolaSTD_+95 542 26000 100000 0.02 0.01

Carrot FLcarrotSTD_+0 584 26000 100000 0.02 0.01

Cereals: Corn 

and Sorghum

MScornSTD_+135 & 

KSCornStd_+160 831

26000 100000 0.03 0.01

Cereals: Wheat 

& others TXwheatOP_+235 804 26000 100000 0.03 0.01
47

Christmas 

Trees Christmas Trees 115 26000 100000 0.00 0.00

Citrus FLcitrusSTD_+145 311 26000 100000 0.01 0.00

Cotton STXcottonNMC_+160 & 

NCcottonSTD_+75 533

26000 100000 0.02 0.01

Cucurbits STXmelonNMC_+9 & 

FLcucumberSTD_+0 582

26000 100000 0.02 0.01

Fruiting 

Vegetables

STXvegetableNMC_+170 & 

FLpeppersSTD_+10 623

26000 100000 0.02 0.01

Ginseng MNsugarbeetSTD_+10 

576 26000 100000 0.02 0.01

Grapes & Small 

Vine Fruits NYGrapesSTD_+90 340 26000 100000 0.01 0.00

Grasses for 

Forage/Seeds ORgrassseedSTD_+160 347

26000 100000 0.01 0.00

Herbs & Spices CAColeCropRLF_V2_+60 610

26000 100000 0.02 0.01

Hops ORhopsSTD_+140 410 26000 100000 0.02 0.00

Leafy 

Vegetables + 

Petiole

CAlettuceSTD_+95 682

26000 100000 0.03 0.01

Legume 

Vegetables 

W/Soybeans

MSsoybeanSTD_+165 634

26000 100000 0.02 0.01

Ornamentals: 

Residential CApervious/imperviousRLF

26000 100000 0.00 0.00

Ornamentals: 

Nurseries MInurserySTD_V2_+230 508

26000 100000 0.02 0.01

Peanut NCpeanutSTD_+140 533 26000 100000 0.02 0.01

Pome Fruits NCappleSTD_+35 276 26000 100000 0.01 0.00

Potato, 

Tuberous/Corm 

Vegies

MEpotatoSTD_+120 877

26000 100000 0.03 0.01

Small Berries CAWineGrapesRLF_V2_+150 224

26000 100000 0.01 0.00

Stone Fruits MICherriesSTD_+80 349 26000 100000 0.01 0.00

Strawberry CAStrawberrynonplasticRLF_V2_+5 650

26000 100000 0.02 0.01

Sugar beet MNsugarbeetSTD_+10 576

26000 100000 0.02 0.01

Sunflower CAcornOP_+140 303 26000 100000 0.01 0.00

Tree nuts GAPecansSTD_+75 378 26000 100000 0.01 0.00
48

Turf PAturfSTD_+60 279 26000 100000 0.01 0.00

Appendix 3: Calculation of the Seed Treatment Applciation rates 

and an Example T-Rex Run for Peanut Seed-Treatment

Chemical Name: Fluopyram ST Application Rate (lb ai/acre)

Seed Treatment? 

(Check if yes)

TRUE Seeding Rate 

(lbs/acre)

 Use: 5 18.9

Product name and 

form: Fluopyram ST

% A.I. (leading zero 

must be entered for 

formulations <1% a.i.): 100.00%

Application rate (fl 

oz/cwt) 3.83

Half-life (days): 35

Application Interval 

(days): 0

Number of 

Applications: 1

Are you assessing 

applications with 

variable rates or 

intervals? no

Endpoints Reported Tested Body Adjusted LD50 

Weight (g) 

Avian LD50: 2000.00 178 1440.86 

Avian repro. 

NOAEC: 46.70 1834.29 

2591.00 

Mammalian 

LD50: 2000.00 350 4395.66 

Mammalian 

NOAEL: 260.00 3556.56 

1538.32 

Adjusted NOAEL for Mammals

Small (15g) 28.57

Medium (35g) 23.12
49

Large (1000g) 10.00

Maximum 

Application 

Rate

Maximum Seed 

Application 

Rate

Avian Nagy 

Dose

Mammalian 

Nagy Dose

Available 

AI

(lbs ai/A) (mg ai/kg seed)

(mg ai/kgbw/day)(mg ai/kgbw/day) (mg ai ft-2)

0.03 1496.09

378.64 316.98

215.92 219.08 0.29

96.67 50.79

Risk Quotients†

Avian (20 g) Mammalian (15 g)

Acute (# 1) Acute (# 2) Chronic Acute (# 1) Acute (# 2) 

0.26 0.01 32.04 0.07 0.00 

Avian (100 g) Mammalian (35 g)

Acute (# 1) Acute (# 2) Chronic Acute (# 1) Acute (# 2) 

0.12 0.00 32.04 0.06 0.00 

Avian (1000 g) Mammalian (1000 g)

Acute (# 1) Acute (# 2) Chronic Acute (# 1) Acute (# 2) 

0.04 0.00 32.04 0.03 0.00 
50

Appendix 4: Calculation of the EECs and RQs from Spray Treatment 

Application rates and an Example T-Rex Run for the maximum 

application rate

Chemical Name: Fluopyram ST

 Use 0

 Formulation Privelege

Application Rate 0.25 lbs a.i./acre

Half-life 35 days 

Application Interval 5 days

Maximum # Apps./Year 2

Length of Simulation 1 year

Variable application rates? no

Endpoints

Avian

Bobwhite quail LD50 (mg/kg-bw) 2000.00

Mallard duck) LC50 (mg/kg-diet) 4604.00

Bobwhite quail NOAEL(mg/kg-bw) 0.00

Bobwhite quail NOAEC (mg/kg-diet) 46.70

Mammals

LD50 (mg/kg-bw) 2000.00

LC50 (mg/kg-diet) 0.00

NOAEL (mg/kg-bw) 13.00

NOAEC (mg/kg-diet) 260.00

Dietary-based EECs 

(ppm)

Kenaga

Values

Short Grass 114.34

Tall Grass 52.41

Broadleaf plants 64.32

Fruits/pods/seeds 7.15

Arthropods 44.78
51

Avian Body 

Ingestion 

(Fdry)

Ingestion 

(Fwet) % body wgt FI

Class Weight (g) (g bw/day) (g/day) consumed (kg-diet/day)

Small 20 5 23 114 2.28E-02

Mid 100 13 65 65 6.49E-02

Large 1000 58 291 29 2.91E-01

20 5 5 25 5.06E-03

Granivores 100 13 14 14 1.44E-02

1000 58 65 6 6.46E-02

Avian Body Adjusted LD50

Weight (g) (mg/kg-bw)

20 1440.86

100 1834.29

1000 2591.00

Dose-based EECs 

(mg/kg-bw)

Avian Classes and Body Weights (grams)

small mid large

20 100 1000

Short Grass 130.23 74.26 33.25

Tall Grass 59.69 34.04 15.24

Broadleaf plants 73.25 41.77 18.70

Fruits/pods 8.14 4.64 2.08

Arthropods 51.01 29.09 13.02

Seeds 1.81 1.03 0.46

Dose-based RQs 

(Dose-based EEC/adjusted LD50)

Avian Acute RQs

Size Class (grams)

20 100 1000

Short Grass 0.09 0.04 0.01

Tall Grass 0.04 0.02 0.01

Broadleaf plants 0.05 0.02 0.01

Fruits/pods 0.01 0.00 0.00

Arthropods 0.04 0.02 0.01

Seeds 0.00 0.00 0.00
52

Dietary-based RQs 

(Dietary-based EEC/LC50 or 

NOAEC)

RQs

Acute Chronic

Short Grass 0.02 2.45

Tall Grass 0.01 1.12

Broadleaf plants 0.01 1.38

Fruits/pods/seeds 0.00 0.15

Arthropods 0.01 0.96

Mammalian Body 

Ingestion 

(Fdry)

Ingestion 

(Fwet) % body wgt FI

Class Weight (g bwt/day) (g/day) consumed (kg-diet/day)

15 3 14 95 1.43E-02

Herbivores/ 35 5 23 66 2.31E-02

insectivores 1000 31 153 15 1.53E-01

15 3 3 21 3.18E-03

Grainvores 35 5 5 15 5.13E-03

1000 31 34 3 3.40E-02

Mammalian Body Adjusted Adjusted

Class Weight LD50 NOAEL

15 4395.66 28.57

Herbivores/ 35 3556.56 23.12

insectivores 1000 1538.32 10.00

15 4395.66 28.57

Granivores 35 3556.56 23.12

1000 1538.32 10.00

Dose-Based EECs 

(mg/kg-bw)

Mammalian Classes and Body weight

(grams)

15 35 1000

Short Grass 109.02 75.35 17.47

Tall Grass 49.97 34.53 8.01

Broadleaf plants 61.32 42.38 9.83

Fruits/pods 6.81 4.71 1.09

Arthropods 42.70 29.51 6.84

Seeds 1.51 1.05 0.24
53

Dosebased 

RQs 

(Dose-based 

EEC/LD50 or 

NOAEL)

Small mammal Medium mammal Large mammal

15 grams 35 grams 

Acute Chronic Acute Chronic Acute 

Short Grass 0.02 3.82 0.02 3.26 0.01 

Tall Grass 0.01 1.75 0.01 1.49 0.01 

Broadleaf plants 0.01 2.15 0.01 1.83 0.01 

Fruits/pods 0.00 0.24 0.00 0.20 0.00 

Arthropods 0.01 1.49 0.01 1.28 0.00 

Seeds 0.00 0.05 0.00 0.05 0.00 

Dietary-based RQs 

(Dietary-based EEC/LC50 or 

NOAEC)

Mammal RQs

Acute Chronic

Short Grass #DIV/0! 0.44

Tall Grass #DIV/0! 0.20

Broadleaf plants #DIV/0! 0.25

Fruits/pods/seeds #DIV/0! 0.03

Arthropods #DIV/0! 0.17