Bicarbonates

**073505 ,**  **073508** Product Chemistry

—Registration Review

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

**MEMORANDUM SUBJECT**  : Product Chemistry Scoping Document for the Registration Review o Bicarbonates (Sodium, Potassium) **Registration Review Case #: PC Code:**  **CAS Numbers: Chemical Class:**  **FROM:** Leonard Cole, Senior Regulatory Specialist Biochemical Pesticides Branch Biopesticides & Pollution Prevention Division (7511P) **TO :**  Linda Hollis, Chief

Biochemical Pesticides Branch Biopesticides & Pollution Prevention Division (7511P)

**ACTION REQUESTED** The following scoping document contains the product chemistry assessment for sodium bicarbonate and potassium bicarbonate Review Preliminary Work Plan.
**Executive Summary**

Registration Review

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460
May 23, 2012 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION Product Chemistry

Scoping Document for the Registration Review o (Sodium, Potassium)
. **Registration Review Case #: 4048**  **073505 , 073508**  **144 -**  **55 -**  **8 , 298**  **- 14**  **- Biochem** **ical** Leonard Cole, Senior Regulatory Specialist Biochemical Pesticides Branch

Pollution Prevention Division (7511P) Linda Hollis, Chief Biochemical Pesticides Branch Biopesticides & Pollution Prevention Division (7511P)

The following scoping document contains the product chemistry assessment for sodium bicarbonate and potassium bicarbonate in support of the development of the Registration Case #: 4048

OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION Product Chemistry

Scoping Document for the Registration Review o f

**- 6** 

The following scoping document contains the product chemistry assessment for the biopesticide s in support of the development of the RegistrationBicarbonates CAS # s **144 -**  **55 -**  **8 , 298**  **- 14**  **- 6** 

**073505 ,**  **073508** The Agency has made the determination that for the purposes of registration review, there is adequate information available on bicarbonates, (including sodium and potassium) , and does not foresee the need for additional biochemical pesticide product chemistry data for products that currently

contain the three bicarbonates outlined above as the te chnical grade active ingredient. **Introduction** The bicarbonates (sodium and potassium) are naturally occurring compounds that are not expected to have adverse effects on humans or the environment when used as fungicides. Use of these two compounds in pe sticide products may provide an alternative to more toxic fungicides currently on the market. The active ingredient s were first registered in 19 94 for use as a fungicide (Potassium bicarbonate and Sodium and Fact Sheet , 1999 )
. There are currently 8 products registered containing the active ingredient , Potassium bicarbonate, and one technical grade active ingredient (TGAI) Sodium bicarbonate
. Both bicarbonates are approved for use as inert ingredients in pesticide formulations. **Product Chemistry Summary** Concerning the product chemistry of the bicarbonates , all biochemical pesticide data requirements for the technical grade active ingredients have been satisf ied and are summarized in Tables 3 and 4 . While no further product chemistry data are necessary

for the products currentl y registered, future registrations must adequately address all of the biochemical pesticides product chemistry data requirements.

**Table 1. Product Identity and Composition for Sodium bicarbonate**  **Chemical Name, IUPAC** Sodium bicarbonateBicarbonates

**073505 ,**  **073508 Molecular Weight**  **PC Code CAS Registry Number**  **Common Name Molecular**  **Formula Registration Review Case Number**  **Chemical Structure** CAS # s
105.9784 g/mol 073505 144
- 55
- 8 Baking soda, bicarbonate of soda NaHCO 3 **Registration Review Case Number** 4 048 s **144 -**  **55 -**  **8 , 298**  **- 14**  **- 6** 

3Bicarbonates

**073505 ,**  **073508**

The Agency

has conducted a review of the Sodium bicarbonate and Potassium bicarbonate **Table 3**  **. Biochemical Pesticides Product Che bicarbonate**  **Guideline No.**  **Physical and Chem**

**Properties 830.1100**  Product Identity and Composition

**830.1200** Description of starting

materials, production and formulation process

**830.1400** Discussion of formation

of impurities **Chemical Name, IUPAC Molecular Weight**  **PC Code CAS Registry Number**  **Common Name Molecular**  **Formula Registration Review Case Number**  **Chemical Structure** CAS # s

The Agency

has conducted a review of the available product chemistry data and information Sodium bicarbonate and Potassium bicarbonate . These data are summarized below. **. Biochemical Pesticides Product Che mi**  **stry Data Requirements for Physical and Chem**  **ical Properties**  **Status 1**  **Value** Product Identity

and A Refer to Table 1.

Description of starting materials, production and formulation process A CBI

Discussion of formation A CBI Potassium bicarbonate 100.115 g/mol 07350 8 298
- 14
- 6 Potassium bicarbonate K2 CO 3 **Registration Review Case Number** 4048 s **144 -**  **55 -**  **8 , 298**  **- 14**  **- 6** 

4 available product chemistry data and information for . These data are summarized below. **Sodium MRID**  00019705 00019706 00019707 43297201 43463101 43463102 00019712 43297201 43463103 43463200 43463201 43463202 43463203 00012547Bicarbonates CAS # s **144 -**  **55 -**  **8 , 298**  **- 14**  **- 6** 

**073505 ,**  **073508**

5 **830.1700** Preliminary anal ys is A CBI 43463200 43463201 43463202 43463203 **830.6302** Color A White crystalline 00019705 00019706 43463101 43463102 **830.6303** Physical state A powder 00019705 00019706 43463101 43463102 **830.6304** Odor A No characteristic odor 43297201 43463101 43463102 **830.6313** Stability

to normal and elevated temperatures, metals and metal ions A Stable to heat and light 00019706 43463101 43463102 **830.7000** pH A 8.3 00019705 00019706 00019707 **830.7050** UV/Visible light

absorption N/A
**830.7200** Melting point/melting

range A 60C (140F) 00019705 00019706 00019707 43297201 **830.7220** Boiling point/boiling

range N/A **830.7300** Density A 2.2 43463101 43463102 **830.7520** Particle size, fiber length,

and diameter distribution N/A Not applicable; chemical is not water insoluble and fibrous with a diameter ≥ 0.1μmBicarbonates CAS # s **144 -**  **55 -**  **8 , 298**  **- 14**  **- 6** 

**073505 ,**  **073508**

6 **830.7550 830.7560**  **830.7570** Partition coefficient (n
Octanol/Water) A Lo g P = 4.320 ChemIDpl us Lite (2012) **830.7840** Water solubility A 8.6 g/100 ml @ 20 C (68 F) 41614403
42501002 **830.7950** Vapor pressure N/A 00019707 43297201 43463101 43463102 1. A=Acceptable. N/A=Not Applicable. N/D=Not Determined. **Table 4. Product Identity and Composition for Potassium bicarbonate Guideline**  **No. Physical and Chemical** 

**Properties Status**  **1 Value**  **MRID 830.1100**  Product Identity and Composition A Refer to Table 2
. 44092500 44092501 44092502 44092503 45444902 **830.1200** Description of starting

materials, production and formulation process A CBI 46026701 48777500 48777501 48777502 **830.1400** Discussion of formation

of impurities A CBI 44326202 46026701 **830.1700** Preliminary anal ys is A CBI 45444901 **830.6302** Color A White crystalline 44092502 44092503 45444902 **830.6303** Physical state A powder 46026701 **830.6304** Odor A No characteristic odor 45444902 **830.6313** Stability

to normal and elevated temperatures, metals and metal ions A Stable to heat and light 44092502 44092503 **830.7000** pH A 8.2 Lilly MSDSBicarbonates CAS # s **144 -**  **55 -**  **8 , 298**  **- 14**  **- 6** 

**073505 ,**  **073508**

7 **830.7050** UV/Visible light

absorption N/A 44092503
**830.7200** Melting point/melting

range N/A **830.7220** Boiling point/boiling

range N/A **830.7300** Density A 2.2 44092502 44092503 **830.7520** Particle size, fiber length,

and diameter distribution N/A Not applicable; chemical is not water insoluble and fibrous with a diameter ≥ 0.1μm **830.7550 830.7560**  **830.7570** Partition coefficient (n
Octanol/Water) A Lo g P = 4.320 ChemIDpl us Lite (2012) **830.7840** Water solubility A 8.6 g/100 ml @ 20 C (68 F) 41614403
42501002 **830.7950** Vapor pressure N/A 00019707 43297201 43463101 43463102
**References** Merck Index, Online. 01/24/2012. US EPA Sodium and Potassium bicarbonate Fact Sheet (1999) http://www.epa.gov/oppbppd1/biopesticides/ingredients/factsheets/factsheet_073508.htm