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                                                                    Exhibit 10.1

                      Form of Lock-Up And Voting Agreement

     This Lock-up and Voting Agreement, dated as of February 24, 2003, (this
"Agreement"), is by and among Dendreon Corporation, a Delaware corporation
("Dendreon"), and the stockholder of Corvas International, Inc., a Delaware
corporation ("Corvas") whose signature appears on the signature pages hereof (a
"Corvas Stockholder"). All capitalized terms used herein without definition
having the respective meanings ascribed to them in the Merger Agreement (as
defined below).

                                   WITNESSETH:

     WHEREAS, contemporaneous with the execution and delivery of this Agreement,
Dendreon, Seahawk Acquisition, Inc., a Delaware corporation and wholly owned
subsidiary of Dendreon ("Sub"), Charger Project LLC, a Delaware limited
liability company of which Dendreon is the sole member ("LLC") and Corvas have
entered into an Agreement and Plan of Merger, of even date herewith (the "Merger
Agreement"); and

     WHEREAS, as a condition and inducement to Dendreon and Sub entering into
the Merger Agreement and incurring the obligations set forth therein, certain
Corvas Stockholders have agreed to vote and to cause to be voted all shares of
Corvas Common Stock now owned or hereafter acquired by them, for and in favor of
the merger of (i) Sub with and into Corvas (the "Merger"), Corvas will be the
surviving corporation in the Merger and will become a wholly owned subsidiary of
Dendreon, and the stockholders of Corvas will become stockholders of Dendreon,
and (ii) Corvas, as the surviving corporation in the Merger, with and into LLC
(the "LLC Merger"), and have agreed to the other terms and provisions contained
herein;

     NOW, THEREFORE, in consideration of the premises and the respective
covenants and agreements set forth herein and in the Merger Agreement, the
parties hereto, intending to be legally bound hereby, agree as follows:

     1. Definitions. Each term used herein with its initial letter capitalized
and not otherwise defined shall have the meaning assigned to such term in the
Merger Agreement. The following terms shall have the respective meanings set
forth below:

          a. "Disposition" shall mean any sale, exchange, assignment, gift,
pledge, mortgage, hypothecation, transfer or other disposition or encumbrance of
all or any part of the rights and incidents of ownership of Corvas Shares,
including the right to vote, and the right to possession of Corvas Shares as
collateral for indebtedness, whether such transfer is outright or conditional,
or for or without consideration, or the agreement to do any of the foregoing.

          b. "Corvas Shares": shall mean: (i) all securities of Corvas
(including all shares of Corvas Common Stock and all options, warrants and other
rights to acquire shares of Corvas Common Stock) owned, beneficially or of
record by the Corvas Stockholder as of the date of this Agreement; and (ii) all
additional securities of Corvas (including all additional shares of Corvas
Common Stock and all additional options, warrants and other rights to acquire
shares

<PAGE>

of Corvas Common Stock) of which the Corvas Stockholder acquires ownership
(beneficially or of record) during the Term.

          c. "Term" shall mean the period commencing on the date hereof and
continuing until the first to occur of (i) the Effective Time of the Merger, or
(c) the termination of the Merger Agreement in accordance with its terms.

          d. "it" or "its", when used with reference to a Person, includes
references to such Persons, regardless of gender or whether such Persons are
natural or corporate.

     2. Voting of Corvas Common Stock.

          a. Corvas Stockholder hereby agrees that, during the Term, at any
meeting (whether annual or special and whether or not an adjourned or postponed
meeting) of the holders of Corvas Common Stock, however called, or in connection
with any written consent of the holders of Corvas Common Stock, the Corvas
Stockholder will appear at the meeting (in person or by proxy) or otherwise
cause the shares of Corvas Common Stock now owned or hereafter acquired by the
Corvas Stockholder to be counted as present thereat for purposes of establishing
a quorum and vote or consent (or cause to be voted or consented) the Corvas
Shares (a) in favor of the adoption of the Merger Agreement and the approval of
all other actions contemplated by the Merger Agreement and this Agreement and
any actions required in furtherance thereof and hereof, (b) against any action
or agreement that would result in a breach in any respect of any covenant or any
other obligation or agreement of Corvas under the Merger Agreement, and (c)
against any action involving Corvas which is intended, or could reasonably be
expected, to impede, interfere with, delay, postpone, or materially adversely
affect the transactions contemplated by the Merger Agreement.

          b. Contemporaneously with the execution of this Agreement: (i) the
Corvas Stockholder shall deliver to Parent a proxy in the form attached to this
Agreement as Exhibit A, which shall be irrevocable to the fullest extent
permitted by law (with respect to the shares referred to therein (the "Proxy");
and (ii) the Corvas Stockholder shall cause to be delivered to Parent an
additional proxy (in the form attached hereto as Exhibit A) executed on behalf
of the record owner of any outstanding shares of Corvas Common Stock that are
owned beneficially (within the meaning of Rule 13d-3 under the Securities
Exchange Act of 1934), but not of record, by Corvas Stockholder.

     3. Restriction on Disposition of Corvas Shares. The Corvas Stockholder
hereby agrees that, during the Term and, if the Merger is consummated, until
5:00 p.m., Pacific time on the day that is 90 days after the date on which the
Effective Time occurs, Corvas Stockholder will not make, offer to make, agree to
make, or suffer any Disposition of its Corvas Shares or, after the Effective
Time, any shares of capital stock into which the Corvas Shares have been
converted ("Converted Shares"), or any interest therein. The restrictions
contained in this Section 3 shall not apply to (a) a Disposition under a Corvas
Stockholder's will or pursuant to the laws of descent and distribution, or (b) a
gift by a Corvas Stockholder to an immediate family member (i.e., a spouse,
child, parent, grandparent or sibling) or a family trust for the benefit of


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<PAGE>

immediate family member(s), so long as, in each case, the transferee(s) deliver
to Dendreon and Sub an executed written instrument agreeing to be bound by the
terms of this Agreement as if such transferee(s) were a Corvas Stockholder.

     4. Restriction on Proxies and Non-Interference. The Corvas Stockholder
hereby agrees that, during the Term, Corvas Stockholder will not (i) grant any
proxies or powers of attorney that would permit any such proxy or
attorney-in-fact to take any action inconsistent herewith, (ii) deposit its
Corvas Shares, as the case may be, into a voting trust or enter into a voting
agreement with respect to such Corvas Shares in either case providing for the
voting or consenting of such shares in a manner inconsistent herewith; or (iii)
take any action that would make any representation or warranty of the Corvas
Stockholder contained herein untrue or incorrect or would result in a breach by
Corvas Stockholder of its obligations under this Agreement. The Corvas
Stockholder further agrees not to enter into any agreement or understanding with
any Person, the effect of which would be inconsistent with or violative of any
provision contained in this Agreement.

     5. Termination. This Agreement will terminate at 5:00, Pacific time upon
the earlier of (a) the date that is 90 days after the date on which the
Effective Time occurs, or (b) the termination of the Merger Agreement in
accordance with its terms (the earlier of (a) and (b), the "Termination Date").

     6. Miscellaneous.

          a. Entire Agreement. This Agreement and the Proxy constitute the
entire agreement among the parties with respect to the subject matter hereof and
supersedes all other prior agreements and understandings, both written and oral,
between the parties with respect to the subject matter hereof.

          b. Certain Events. The Corvas Stockholder agrees that this Agreement
and the Proxy and the obligations hereunder shall attach to its Corvas Shares
and shall be binding upon any Person to which legal or beneficial ownership of
such Corvas Shares shall pass, whether by operation of law or otherwise,
including, without limitation, Corvas Stockholder's heirs, guardians,
administrators or successors. Notwithstanding any such transfer of Corvas
Shares, the transferor shall remain liable for the performance of all
obligations under this Agreement of the transferor.

          c. Stock Dividends or Distributions. In the event of a stock dividend
or distribution, or any change in the Corvas Common Stock or, after the
Effective Time, the Converted Shares by reason of any stock dividend, split-up,
recapitalization, combination, exchange of shares or the like, (i) the terms
"Corvas Shares" and "Converted Shares" shall be deemed to refer to and include
the Corvas Shares or Converted Shares, as the case may be, as well as all such
stock dividends and distributions and any shares into which or for which any or
all of the Corvas Shares or Converted Shares, as the case may be, may be changed
or exchanged.

          d. Acquisition of Additional Shares. The Corvas Stockholder agrees to
promptly notify Dendreon of the number of shares of Corvas Common Stock (or,
after the


                                       3

<PAGE>

Effective Time, Dendreon Common Stock) acquired by the Corvas Stockholder, if
any, after the date of this Agreement. Any such shares of Dendreon Common Stock
shall, after their acquisition by the Corvas Stockholder, be subject to the
restrictions on transfer applicable to the Converted Shares.

          e. Waiver of Appraisal Rights. The Corvas Stockholder hereby waives,
releases and discharges any rights of appraisal or rights to dissent from the
Merger that Corvas Stockholder may have.

          f. Assignments: Rights of Assignees; Third Party Beneficiaries. This
Agreement shall not be assignable by the Corvas Stockholder without the prior
written consent of Dendreon. This Agreement shall be binding upon, inure to the
benefit of, and be enforceable by, the parties hereto and their respective
heirs, executors, administrators, legal representatives, successors and
permitted assigns. Nothing expressed or referred to in this Agreement is
intended or shall be construed to give any Person other than the parties to this
Agreement or their respective heirs, executors, administrators, legal
representatives, successors or permitted assigns any legal or equitable right,
remedy or claim under or in respect of this Agreement or any provision contained
herein.

          g. Specific Performance. The parties hereto acknowledge that money
damages are an inadequate remedy for breach of this Agreement or the Proxy
because of the difficulty of ascertaining the amount of damage that will be
suffered by the non-breaching party or parties in the event that this Agreement
or the Proxy is breached. Therefore, each of the parties agrees that the
non-breaching party or parties may obtain specific performance of this Agreement
or the Proxy and injunctive and other equitable relief against any breach
hereof, without the necessity of establishing irreparable harm or posting any
bond, in addition to any other remedy to which such party may be entitled at law
or in equity.

          h. Waiver. No waiver of any provision of this Agreement shall be
effective unless it is in writing signed by the party granting the waiver, and a
waiver by any party hereto of any one or more defaults shall not operate as a
waiver of any future default or defaults, whether of a like or of a different
character. No waiver of any of the provisions of this Agreement shall constitute
a waiver of any other provisions (whether or not similar), nor shall such a
waiver constitute a continuing waiver, unless otherwise expressly provided.

          i. Section Headings. Headings contained in this Agreement are inserted
only as a matter of convenience and in no way define, limit, or extend the scope
or intent of this Agreement or any provisions thereof.

          j. Choice of Law; Jurisdiction and Venue. This Agreement and the Proxy
will be governed by and construed and enforced in accordance with the laws of
the State of Delaware (without regard to the principles of conflicts of law)
applicable to a contract executed and to be performed in such State. Each party
hereto (i) agrees to submit to personal jurisdiction and to waive any objection
as to venue in the state or federal courts located in New Castle County,
Delaware, (ii) agrees that any action or proceeding shall be brought exclusively
in such courts, unless subject matter jurisdiction or personal jurisdiction
cannot be obtained, and (iii)


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agrees that service of process on any party in any such action shall be
effective if made by registered or certified mail addressed to such party at the
address specified herein, or to any parties hereto at such other addresses as
he, she or it may from time to time specify to the other parties in writing for
such purpose. The exclusive choice of forum set forth in this paragraph shall
not be deemed to preclude the enforcement of any judgment obtained in such forum
or the taking of any action under this Agreement to enforce such judgment in any
appropriate jurisdiction.

          k. Notices. All notices, requests and other communications to any
party hereunder shall be in writing and will be deemed to have been duly given
only if delivered personally or by facsimile transmission or mailed (first class
mail postage prepaid), or by overnight express courier (charges prepaid or
billed to the account of the sender) to the parties at the following addresses
or facsimile numbers:

          If to Dendreon, to:

                    3005 First Avenue
                    Seattle, WA 98121
                    Attention: Chairman

          If to the Corvas Stockholder: At its address set forth on the
     signature page hereto or to such other address or fax number as any party
     may have furnished to the others in writing in accordance herewith.

          l. Counterparts. This Agreement may be executed in any number of
counterparts, each of which shall be deemed to be an original, but all of which
together shall constitute one and the same document.

          m. Severability of Provisions. If any term, provision, covenant or
restriction of this Agreement is held by a court of competent jurisdiction to be
invalid, void or unenforceable, (i) such term, provision, covenant or
restriction shall, unless no such amended provision would be valid or
enforceable, be deemed amended to the minimum extent necessary to cause it, as
so amended, to be valid and enforceable, and (ii) the remainder of the terms,
provisions, covenants and restrictions of this Agreement shall remain in full
force and effect and shall not in any way be affected, impaired or invalidated.

     7. Effectiveness. This Agreement shall become effective simultaneously with
the execution and delivery of the Merger Agreement.


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<PAGE>

         IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be
duly executed as of the date first set forth above.


                                       DENDREON CORPORATION

                                       By:
                                          --------------------------------------


                                       STOCKHOLDER


                                       -----------------------------------------
                                       Name:

                                       Address:
                                                  ------------------------------

                                                  ------------------------------

                                       Facsimile:
                                                  ------------------------------

<TABLE>
<S>                          <C>                             <C>
Shares Held of Record        Options and Other Rights        Additional Securities Beneficially Owned
---------------------        ------------------------        ----------------------------------------
</TABLE>


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                                IRREVOCABLE PROXY

     The undersigned stockholder (the "Stockholder") of CORVAS INTERNATIONAL,
INC., a Delaware corporation (the "Company"), hereby irrevocably (to the fullest
extent permitted by law) appoints and constitutes Martin A. Simonetti, T. Dennis
George and DENDREON CORPORATION, a Delaware corporation ("Parent"), and each of
them, the attorneys and proxies of the Stockholder with full power of
substitution and resubstitution, to the full extent of the Stockholder's rights
with respect to (i) the outstanding shares of capital stock of the Company owned
of record by the Stockholder as of the date of this proxy, which shares are
specified on the final page of this proxy, and (ii) any and all other shares of
capital stock of the Company which the Stockholder may acquire on or after the
date hereof. (The shares of the capital stock of the Company referred to in
clauses "(i)" and "(ii)" of the immediately preceding sentence are collectively
referred to as the "Shares.") Upon the execution hereof, all prior proxies given
by the Stockholder with respect to any of the Shares are hereby revoked, and the
Stockholder agrees that no subsequent proxies will be given with respect to any
of the Shares.

     This proxy is irrevocable, is coupled with an interest and is granted in
connection with the Voting Agreement, dated as of the date hereof, between
Parent and the Stockholder (the "Voting Agreement"), and is granted in
consideration of Parent entering into the Agreement and Plan of Merger, dated as
of the date hereof, among Parent, Seahawk Acquisition, Inc., Charger Project LLC
and the Company (the "Merger Agreement"). This proxy will terminate on the
Termination Date (as defined in the Voting Agreement).

     The attorneys and proxies named above will be empowered, and may exercise
this proxy, to vote the Shares at any time until the earlier to occur of the
valid termination of the Merger Agreement or the effective time of the merger
contemplated thereby (the "Merger") at any meeting of the stockholders of the
Company, however called, and in connection with any written action by consent of
stockholders of the Company:

          (i) in favor of the Merger, the execution and delivery by the Company
     of the Merger Agreement and the adoption and approval of the Merger
     Agreement and the terms thereof, in favor of each of the other actions
     contemplated by the Merger Agreement and in favor of any action in
     furtherance of any of the foregoing; and

          (ii) against any action or agreement that would result in a breach of
     any covenant or obligation of the Company in the Merger Agreement; and

          (iii) against any other action which is intended, or could reasonably
     be expected to impede, interfere with, delay, postpone, discourage or
     adversely affect the Merger or any of the other transactions contemplated
     by the Merger Agreement.

     The Stockholder may vote the Shares on all other matters not referred to in
this proxy, and the attorneys and proxies named above may not exercise this
proxy with respect to such other matters.


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This proxy shall be binding upon the heirs, estate, executors, personal
representatives, successors and assigns of the Stockholder (including any
transferee of any of the Shares).

     If any provision of this proxy or any part of any such provision is held
under any circumstances to be invalid or unenforceable in any jurisdiction, then
(a) such provision or part thereof shall, with respect to such circumstances and
in such jurisdiction, be deemed amended to conform to applicable laws so as to
be valid and enforceable to the fullest possible extent, (b) the invalidity or
unenforceability of such provision or part thereof under such circumstances and
in such jurisdiction shall not affect the validity or enforceability of such
provision or part thereof under any other circumstances or in any other
jurisdiction, and (c) the invalidity or unenforceability of such provision or
part thereof shall not affect the validity or enforceability of the remainder of
such provision or the validity or enforceability of any other provision of this
proxy. Each provision of this proxy is separable from every other provision of
this proxy, and each part of each provision of this proxy is separable from
every other part of such provision.

Dated:  February __, 2003


                                       -----------------------------------------
                                       Name:



                                       Number of shares of common stock of the
                                       Company owned of record as of the date of
                                       this proxy:


                                       -----------------------------------------







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