U.S. Environmental Protection Agency December 2010

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List of References to BPA-Related Environmental Studies 

Published from 2007 through 2010 

Abstracts from Fourteenth International Symposium on Pollutant Responses in Marine 

Organisms (PRIMO 14) – Genotoxicity. Mar. Env. Res. 66(1): 64-68. 

Ahn, Y.G., Shin, J.H., Kim, H.-Y., Khim, J., Lee, M.-K., Hong, J. 2007. Application of solidphase extraction coupled with freezing-lipid filtration clean-up for the determination of 

endocrine-disrupting phenols in fish. Anal. Chim. Acta 603(1): 67-75. 

Airas, S., Leppänen, M., Kukkonen, J.V.K. 2008. Effects of temperature and oxygen 

concentration in sediment toxicity testing. Ecotox. Env. Saf. 70(3): 475-482. 

Al-Rifai, J.H., Gabelish, C.L., Schäfer, A.I. 2007. Occurrence of pharmaceutically active and 

non-steroidal estrogenic compounds in three different wastewater recycling schemes in 

Australia. Chemos. 69(5): 803-815. 

Alyea, R.A., Watson, C.S. 2009. Differential regulation of dopamine transporter function and 

location by low concentrations of environmental estrogens and 17beta-estradiol. Env. Health 

Perspect. 117(5): 778-83. 

Aoki, J., Nagae, M., Takao, Y., Hara, A., Lee, Y.D., Yeo, I.K., Lim, B.S., Park, C.B., Soyano, 

K. 2010. Survey of contamination of estrogenic chemicals in Japanese and Korean coastal 

waters using the wild grey mullet (Mugil cephalus). Sci. Total Env. 408(3): 660-665. 

Arditsoglou, A., Voutsa, D. 2008. Passive sampling of selected endocrine disrupting 

compounds using polar organic chemical integrative samplers. Env. Poll. 156(2):316-24. 

 

Ardon, F., Rodriguez-Miranda, E., Beltran, C., Hernandez-Cruz, A., Darszon, A. 2009. 

Mitochondrial inhibitors activate influx of external Ca2+ in sea urchin sperm. Bioch. 

Biophysica Acta 1787(1): 15-24. 

Auriol, M., Filali-Meknassi, Y., Adams, C.D., Tyagi, R.D., Noguerol, T.-N., Piña, B. 2008. 

Removal of estrogenic activity of natural and synthetic hormones from a municipal wastewater: 

Efficiency of horseradish peroxidase and laccase from Trametes versicolor. Chemos. 70(3): 

445-452. 

Auriol, M., Filali-Meknassi, Y., Tyagi, R.D., Adams, C.D. 2007. Oxidation of natural and 

synthetic hormones by the horseradish peroxidase enzyme in wastewater. Chemos. 68(10): 

1830-1837. 

Baek, H.J., Hwang, I.J., Kim, K.S., Lee, Y.D., Kim, H.B., Yoo, M.S. 2007. Effects of BPA 

and DES on longchin goby (Chasmichthys dolichognathus) in vitro during the oocyte 

maturation. Mar. Env. Res. 64(1): 79-86. 
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Baer, K.N., McCoole, M.D. 2009. Overturf Modulation of sex ratios in Daphnia magna

following multigenerational exposure to sewage treatment plant effluents. Ecotox. Env. Saf.

72(5): 1545-1550. 

Bang, H.W., Lee, W., Kwak, I.-S. 2009. Detecting points as developmental delay based on the 

life-history development and urosome deformity of the harpacticoid copepod, Tigriopus 

japonicus sensu lato, following exposure to benzo(a)pyrene. Chemos. 76(10): 1435-1439. 

Baptista, M.S., Stoichev, T., Basto, M.C.P., Vasconcelos, V.M., Vasconcelos, M.T.S.D. 2009. 

Fate and effects of octylphenol in a Microcystis aeruginosa culture medium. Aqua. Tox. 92(2): 

59-64. 

Barber, L.B., Lee, K.E., Swackhamer, D.L., Schoenfuss, H.L. 2007. Reproductive responses 

of male fathead minnows exposed to wastewater treatment plant effluent, effluent treated with 

XAD8 resin, and an environmentally relevant mixture of alkylphenol compounds. Aqua. Tox. 

82(1): 36-46. 

Barnabé, S., Brar, S.K., Tyagi, R.D., Beauchesne, I., Surampalli, R.Y. 2009. Pre-treatment and 

bioconversion of wastewater sludge to value-added products—Fate of endocrine disrupting 

compounds. Sci. Total Env. 407(5): 1471-1488. 

Barnes, K.K., Kolpin, D.W., Furlong, E.T., Zaugg, S.D., Meyer, M.T., Barber, L.B. 2008 A 

national reconnaissance of pharmaceuticals and other organic wastewater contaminants in the 

United States — I) Groundwater. Sci. Total Env. 402(2-3): 192-200. 

Bastos, P.M., Eriksson, J., Green, N., Bergman, Å. 2008. A standardized method for 

assessment of oxidative transformations of brominated phenols in water. Chemos. 70(7): 1196-

1202. 

Bertin, A., Inostroza, P.A., Quiñones, R.A. 2009. A theoretical estimation of the concentration 

of steroid estrogens in effluents released from municipal sewage treatment plants into aquatic 

ecosystems of central-southern Chile. Sci Total Env. 407(17): 4965-4971. 

Bicchi, C., Schilirò, T., Pignata, C., Fea, E., Cordero, C., Canale, F., Gilli, G. 2009. Analysis 

of environmental endocrine disrupting chemicals using the E-screen method and stir bar 

sorptive extraction in wastewater treatment plant effluents. Sci. Total Env. 407(6): 1842-1851. 

Bickley, L.K. , Lange, A., Winter, M.J., Tyler, C.R. 2009. Evaluation of a carp primary 

hepatocyte culture system for screening chemicals for oestrogenic activity. Aqua. Tox. 94(3): 

195-203. 

Birch, G.F., Harrington, C., Symons, R.K., Hunt, J.W. 2007. The source and distribution of 

polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofurans in sediments of Port 

Jackson, Australia. Mar. Poll. Bull. 54(3): 295-308. 
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Bjerregaard, L.B., Lindholst, C., Korsgaard, B., Bjerregaard, P. 2008. Sex hormone 

concentrations and gonad histology in brown trout (Salmo trutta) exposed to 17β-estradiol and 

bisphenol A. Ecotox. 17(4): 252-263. 

Bjerregaard, P., Andersen, S.B., Pedersen, K.L., Pedersen, S.N., Korsgaard, B. 2007. Orally 

administered bisphenol A in rainbow trout (Oncorhynchus mykiss): Estrogenicity, metabolism, 

and retention. Env. Tox. Chem. 26(9): 1910-1915. 

Björkblom, C., Salste, L., Katsiadaki, I., Wiklund, T., Kronberg, L. 2008. Detection of 

estrogenic activity in municipal wastewater effluent using primary cell cultures from threespined stickleback and chemical analysis. Chemos. 73(7): 1064-1070. 

Boehme, R.M., Andries, T., Dötz, K.H., Thiele, B., Guenther, K. 2010. Synthesis of defined 

endocrine-disrupting nonylphenol isomers for biological and environmental studies. Chemos. 

80(7): 813-821. 

Breitholtz, M., Nyholm, J.R., Karlsson, J., Andersson, P.L. 2008. Are individual NOEC levels 

safe for mixtures? A study on mixture toxicity of brominated flame–retardants in the copepod 

Nitocra spinipes. Chemos. 72(9): 1242-1249. 

Brian, J.V., Beresford, N., Walker, J., Pojana, G., Fantinati, A., Marcomini, A., Sumpter, J.P. 

2009. Hypoxia Does Not Influence the Response of Fish to a Mixture of Estrogenic Chemicals. 

Env. Sci. Tech. 43(1): 214-218. 

Brian, J.V., Harris, C.A., Runnalls, T.J., Fantinati, A., Pojana, G., Marcomini, A., Booy, P., 

Lamoree, M., Kortenkamp, A., Sumpter, J.P. 2008. Evidence of temperature-dependent effects 

on the estrogenic response of fish: Implications with regard to climate change. Sci. Total Env.

397(1-3): 72-81. 

Brian, J.V., Harris, C.A., Scholze, M., Kortenkamp, A., Booy, P., Lamoree, M., Pojana, G., 

Jonkers, N., Marcomini, A., Sumpter, J.P. 2007. Evidence of Estrogenic Mixture Effects on 

the Reproductive Performance of Fish. Env. Sci. Tech. 41(1): 337-344. 

Brown, K.H., Schultz, I.R., Nagler, JJ. 2009. Lack of a heritable reproductive defect in the 

offspring of male rainbow trout exposed to the environmental estrogen 17α-ethynylestradiol. 

Aqua. Tox. 91(1): 71-74. 

Bucher, J.R. 2009. Bisphenol A: where to now? Env. Health Perspect. 117(3): A96-7. 

Bugel, S.M., White, L.A., Cooper, K.R. 2010. Impaired reproductive health of killifish 

(Fundulus heteroclitus) inhabiting Newark Bay, NJ, a chronically contaminated estuary. Aqua. 

Tox. 96(3): 182-193. 
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Cabana, H., Jiwan, J.-L.H., Rozenberg, R., Elisashvili, V., Penninckx, M., Agathos, S.N., 

Jones, J.P. 2007. Elimination of endocrine disrupting chemicals nonylphenol and bisphenol A 

and personal care product ingredient triclosan using enzyme preparation from the white rot 

fungus Coriolopsis polyzona. Chemos. 67(4): 770-77. 

Cajaraville, M.P., Ortiz-Zarragoitia, M. 2007. Specificity of the peroxisome proliferation 

response in mussels exposed to environmental pollutants. Aqua. Tox. 81(2): 232. 

Cajthaml, T., Křesinová, Z., Svobodová, K., Möder, M. 2009. Biodegradation of endocrinedisrupting compounds and suppression of estrogenic activity by ligninolytic fungi. Chemos.

75(6): 745-50. 

Cajthaml, T., Křesinová, Z., Svobodová, K., Sigler, K., Řezanka, T. 2009. Microbial 

transformation of synthetic estrogen 17α-ethinylestradiol. Env. Poll. 157(12): 3325-3335. 

Cajthaml, T., Křesinová, Z., Svobodová, L., Möder, M. 2009. Biodegradation of endocrinedisrupting compounds and suppression of estrogenic activity by ligninolytic fungi. Chemos.

75(6): 745-750. 

Calafat, A.M., Ye, X., Wong, L.Y., Reidy, J.A., Needham, L.L. Exposure of the U.S. 

population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Env. Health. Perspect.

116(1):39-44. 

Canesi, L., Borghi, C., Ciacci, C., Fabbri, R., Lorusso, L.C., Vergani, L., Marcomini, A., 

Poiana, G. 2008. Short-term effects of environmentally relevant concentrations of EDC 

mixtures on Mytilus galloprovincialis digestive gland. Aqua. Tox. 87(4): 272-279. 

Canesi, L., Borghi, C., Ciacci, C., Fabbri, R., Vergani, L., Gallo, G. 2007. Bisphenol-A alters 

gene expression and functional parameters in molluscan hepatopancreas. Mol. Cell. Endoc.

276(1-2): 36-44. 

Canesi, L., Fabbri, R., Gallo, G., Vallotto, D., Marcomini, A., Pojana, G. 2010. Biomarkers in 

Mytilus galloprovincialis exposed to suspensions of selected nanoparticles (Nano carbon black, 

C60 fullerene, Nano-TiO2, Nano-SiO2). Aqua. Tox. 100(2): 168-177. 

Canesi, L., Lorusso, L.C., Ciacci, C., Betti, M., Regoli, F., Poiana, G., Gallo, G., Marcomini, A. 

2007. Effects of blood lipid lowering pharmaceuticals (bezafibrate and gemfibrozil) on 

immune and digestive gland functions of the bivalve mollusc, Mytilus galloprovincialis. 

Chemos. 69(6): 994-1002. 

Canesi, L., Lorusso, L.C., Ciacci, C., Betti, M., Rocchi, M., Pojana, G., Marcomini, A. 2007. 

Immunomodulation of Mytilus hemocytes by individual estrogenic chemicals and 

environmentally relevant mixtures of estrogens: In vitro and in vivo studies. Aqua. Tox. 81(1): 

36-44. 
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Cangialosi, M.V., Mansueto, V., Puccia, E., Faqi, A. Developmental toxicity of Bisphenol A 

(BPA) in Ciona intestinalis (Ascidiacea, Urochordata). Birth Defects Res. 85(5): 422. 

Cao, Q., Garib, V., Yu, Q., Connell, D.W., Capitelli, M. 2009. Quantitative structure–property 

relationships (QSPR) for steroidal compounds of environmental importance. Chemos. 76(4): 

453-459. 

Castro, L.F.C.C., Melo, C., Guillot, R., Mendes, I., Queirós, S., Lima, D., Reis-Henriques, 

M.A., Santos, M.M. 2007. The estrogen receptor of the gastropod Nucella lapillus: 

Modulation following exposure to an estrogenic effluent? Aqua. Tox. 84(4): 465-468. 

Céspedes, R., Lacorte, S., Ginebreda, A., Barceló, D. 2008. Occurrence and fate of 

alkylphenols and alkylphenol ethoxylates in sewage treatment plants and impact on receiving 

waters along the Ter River (Catalonia, NE Spain). Env.Poll. 153(2): 384-392. 

Chen, C.-Y., Wen, T.-Y., Wang, G.-S., Cheng, H.-W., Lin, Y.-H., Lien, G.-W. 2007. 

Determining estrogenic steroids in Taipei waters and removal in drinking water treatment using 

high-flow solid-phase extraction and liquid chromatography/tandem mass spectrometry. Sci. 

Total Env. 378(3): 352-365. 

Chen, H., Hu, J., Yang, J., Wang, Y., Xu, H., Jiang, Q., Gong, Y., Gu, Y., Song, H. 2010. 

Generation of a fluorescent transgenic zebrafish for detection of environmental estrogens. 

Aqua. Tox. 96(1): 53-61. 

Chen, H.-C., Kuo, H.-W., Ding, W.-H. 2009. Determination of estrogenic compounds in 

wastewater using liquid chromatography–tandem mass spectrometry with electrospray and 

atmospheric pressure photoionization following desalting extraction. Chemos. 74(4): 508-514. 

Chen, M.-L., Chang, C.-C., Shen, Y.-J., Hung, J.-H., Guo, B.-R., Chuang, H.-Y., Mao, I.-F. 

2008. Quantification of prenatal exposure and maternal-fetal transfer of nonylphenol. Chemos. 

73(1) Supplement 1: S239-S245. 

Chen, P.-J., Kullman, S.W., Hinton, D.E., Linden, K.G. 2007. Comparisons of polychromatic 

and monochromatic UV-based treatments of bisphenol-A in water via toxicity assessments. 

Chemos. 68(6): 1041-1049. 

Chen, P.-J., Rosenfeldt, E.J., Kullman, S.W., Hinton, D.E., Linden, K.G. 2007. Biological 

assessments of a mixture of endocrine disruptors at environmentally relevant concentrations in 

water following UV/H2O2 oxidation. Sci. Total Env. 376(1-3): 18-26. 

Chen, T.-C., Shue, M.-F., Yeh, Y.-L., Hsieh, C.-Y., Kuo, Y.-T., Kuo, C.-T. 2009. Variation, 

correlation, and toxicity of phenolic endocrine-disrupting compounds in surface water. J. Env. 

Sci. Health, Part A: Toxic. Haz. Sub.Env. Eng. 44(12): 1244-1250. 

Chen, T.-S., Chen, T.-C., Yeh, K.-J. C., Chao, H.-R., Liaw, E.-T., Hsieh, C.-Y., Chen, K.-C., 

Hsieh, L.-T., Yeh, Y.-L. 2010. High estrogen concentrations in receiving river discharge from 

a concentrated livestock feedlot. Sci. Total Env. 408(16): 3223-3230. 
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Chen, X., Kinoshita, M., Hirata, T., Yu, R. Man K., Cheng, S.H. 2007. Transgenic marine 

medaka (Oryzias melastigma): a sensitive sentinel for estrogenic pollutants. Mol. Cell. Tox. 3(4) 

Suppl. S: 34. 

Chen, X., Li, V.W.T., Yu, R.M.K., Cheng, S.H. 2008. Choriogenin mRNA as a sensitive 

molecular biomarker for estrogenic chemicals in developing brackish medaka (Oryzias 

melastigma). Ecotox. Env. Saf. 71(1): 200-208. 

Chou, C.-T., Hsiao, Y.-C., Ko, F.-C., Cheng, J.-O., Cheng, Y.-M., ChenT.-H. 2010. Chronic 

exposure of 2,2′,4,4′-tetrabromodiphenyl ether (PBDE-47) alters locomotion behavior in 

juvenile zebrafish (Danio rerio). Aqua.Tox. 98(4): 388-395. 

Clubbs, R.L., Brooks, B.W. 2007. Daphnia magna responses to a vertebrate estrogen receptor 

agonist and an antagonist: A multigenerational study. Ecotox. Env. Saf. 67(3): 385-398. 

Conkle, J.L., White, J.R., Metcalfe, C.D. 2008. Reduction of pharmaceutically active 

compounds by a lagoon wetland wastewater treatment system in Southeast Louisiana. Chemos.

73(11):1741-1748. 

Conroy, O., Sáez, A.E., Quanrud, D., Ela, W., Arnold, R.G. 2007. Changes in estrogen/antiestrogen activities in ponded secondary effluent. Sci. Total Env. 382(2-3): 311-323. 

Contardo-Jara, V., Wiegand, C. 2008. Molecular biomarkers of Dreissena polymorpha for 

evaluation of renaturation success of a formerly sewage polluted stream. Env. Poll. 155(1): 182-

189. 

Cooper, E.R., Siewicki, T.C., Phillips, K. 2008. Preliminary risk assessment database and risk 

ranking of pharmaceuticals in the environment. Sci. Total Env. 398(1-3): 26-33. 

Correa-Reyes, G., Viana, M.T., Marquez-Rocha, F.J., Licea, A.F., Ponce, E., Vazquez-Duhalt, 

R. 2007. Nonylphenol algal bioaccumulation and its effect through the trophic chain. Chemos. 

68(4): 662-670. 

Correia, A.D., Freitas, S., Scholze, M., Goncalves, J.F., Booij, P., Lamoree, M.H., Mananos, E., 

Reis-Henriques, M.A. 2007. Mixtures of Estrogenic Chemicals Enhance Vitellogenic 

Response in Sea Bass. Env. Health Persp. 115(Suppl. 1): 115-121. 

Cosnefroy, A., Brion, F., Guillet, B., Laville, N., Porcher, J. M., Balaguer, P., Ait-Aissa, S. 

2009. A stable fish reporter cell line to study estrogen receptor transactivation by 

environmental (xeno)estrogens. Tox. in Vitro 23(8): 1450-1454. 

Craig D. Robinson, C.D., Elaine Brown, E., John A. Craft, J.A., Ian M. Davies, I.M., Colin 

Megginson, C., Colin Miller, C., Colin F. Moffat, C.F. 2007. Bioindicators and reproductive 

effects of prolonged 17β-oestradiol exposure in a marine fish, the sand goby (Pomatoschistus 

minutus). Aqua. Tox. 81(4): 397-408. 
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Crain, D.A., Eriksen, M., Iguchi, T., Jobling, S., Laufer, H., LeBlanc, G.A., Guillette, L.J. Jr. 

2007. An ecological assessment of bisphenol-A: Evidence from comparative biology. Repro. 

Tox. 24(2): 225-239. 

Creusot, N., Kinani, S., Balaguer, P., Tapie, N., LeMenach, K., Maillot-Marechal, E., Porcher, 

J.-M., Budzinski, H., Ait-Aissa, S. 2010. Evaluation of an hPXR reporter gene assay for the 

detection of aquatic emerging pollutants: screening of chemicals and application to water 

samples. Anal. Bioanalyt. Chem. 396(2): 569-583. 

Crofton, K.M., Paul, K.B., De Vito, M.J., Hedge, J.M. 2007. Short-term in vivo exposure to 

the water contaminant triclosan: Evidence for disruption of thyroxine. Env. Toxic. Pharma. 

24(2): 194-197. 

Croteau, M.C., Davidson, M., Duarte-Guterman, P., Wade, M., Popesku, J.T., Wiens, S., Lean, 

D.R.S., Trudeau, V.L. 2009. Assessment of thyroid system disruption in Rana pipiens

tadpoles chronically exposed to UVB radiation and 4-tert-octylphenol. Aqua. Tox. 95(2): 81-92. 

Cullen, L.T. 2008. Freshen up your drink. Reusing water bottles is good ecologically, but is it 

bad for your health? How to drink smart. Time. 171(12): 65. 

Dang, Z.C. 2010. Comparison of relative binding affinities to fish and mammalian estrogen 

receptors: The regulatory implications. Tox. Letters 192(3): 298-315. 

Danzl, E., Sei, K., Soda, S., Ike, M., Fujita, M. 2009. Biodegradation of bisphenol A, 

bisphenol F and bisphenol S in seawater. Int. J. Env. Res. Public Health. 6(4): 1472-84. 

Dargnat, C., Teil, M.-J., Chevreuil, M., Blanchard, M. 2009. Phthalate removal throughout 

wastewater treatment plant: Case study of Marne Aval station (France). Sci. Total Env. 407(4): 

1235-1244. 

Datta, C., Datta, S., Chowdhury, R.U. B. 2009. The chemical BPA - a threat to human life? 

Indian J. of Foren. Med. & Tox. 3(1): 21-25. 

David, A., Fenet, H., Gomez, E. 2009. Alkylphenols in marine environments: Distribution 

monitoring strategies and detection considerations. Mar. Poll. Bull. 58(7) 953-960. 

de Montgolfier, B., Fournier, M., Audet, C., Marcogliese, D.J., Cyr, D.G. 2008. Influence of 

municipal effluents on the expression of connexins in the brook trout (Salvelinus fontinalis) 

testis. Aqua. Tox. 86(1): 38-48. 

de Vlaming, V., Biales, A., Riordan, D., Markiewicz, D., Holmes, R., Otis, P., Zander, R., 

Lazorchak, J. 2007. Screening California surface waters for estrogenic endocrine disrupting 

chemicals (EEDC) with a juvenile rainbow trout liver vitellogenin mRNA procedure. Sci. Total 

Env. 385(1-3): 66-79. 
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de Wit, C.A., Herzke, D., Vorkamp, K. 2009. Brominated flame retardants in the Arctic 

environment — trends and new candidates. Sci. Total Env. 408(15): 2885-2918. 

Devillers, J., Doucet, J.-P., Panaye, A., Marchand-Geneste, N., Porcher, J.-M. 2009. Structureactivity modeling of a diverse set of androgen receptor ligands. Endoc. Disrup. Mod.: 335-355. 

Florida: CRC Press. 

Dias, V., Vasseur, C., Bonzom, J.M. 2008. Exposure of Chironomus riparius larvae to 

uranium: Effects on survival, development time, growth, and mouthpart deformities. Chemos.

71(3): 574-581. 

Dobbins, L.L., Brain, R.A., Brooks, B.W. 2008. Comparison of the sensitivities of common in 

vitro and in vivo assays of estrogenic activity: application of chemical toxicity distributions. 

Env. Tox. Chem. 27(12): 2608-2616. 

Dong, J., Li X.-L., Liang, R.-J. 2009. Bisphenol A Pollution of Surface Water and Its 

Environmental Factors. J. Ecol. Rural Env. 25(2): 94-97. 

Douxfils, J., Mandiki, R., Silvestre, F., Bertrand, A., Leroy, D., Thomé, J.-P., Kestemont, P. 

2007. Do sewage treatment plant discharges substantially impair fish reproduction in polluted 

rivers? Sci. Total Env. 372(2-3): 497-514. 

Duan, Z., Zhu, L., Zhu, L., Kun, Y., Zhu, X. 2008. Individual and joint toxic effects of 

pentachlorophenol and bisphenol A on the development of zebrafish (Danio rerio) embryo. 

Ecotox. Env. Saf. 71(3): 774-780. 

Duan, Z.-H., Zhang, B.-T., Zhu, L. 2008. The toxicity and bioaccumulation of bisphenol A on 

developmental stages of zebrafish embryo. Zhongguo Huanjing Kexue 28(3): 260-263. 

Duan, Z.-H., Zhu, L., Wang, P., Zhang, B.-T. 2007. Toxicities of bisphenol A on different 

developed stages of zebrafish (Danio rerio) and their mechanisms. Huanjing Huaxue 26(4): 

491-494. 

Duong, C.N., Ra, J.S., Cho, J., Kim, S.D., Choi, H.K., Park, J.-H., Kim, K.W., Inam, E., Kim, 

S.D. 2010. Estrogenic chemicals and estrogenicity in river waters of South Korea and seven 

Asian countries. Chemos. 78(3): 286-293. 

Duft, M., Schmitt, C., Bachmann, J., Brandelik, C., Schulte-Oehlmann, U., Oehlmann, J. 2007. 

Prosobranch snails as test organisms for the assessment of endocrine active chemicals - an 

overview and a guideline proposal for a reproduction test with the freshwater mudsnail 

Potamopyrgus antipodarum. Eco. 16(1): 169-182. 

Duong, C.N., Schlenk, D., Chang, N.I., Kim, S.D. 2009. The effect of particle size on the 

bioavailability of estrogenic chemicals from sediments. Chemos. 76(3): 395-401. 
U.S. Environmental Protection Agency December 2010

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Fatta-Kassinos, D., Kalavrouziotis, I.K., Koukoulakis, P.H., Vasquez, M.I. 2010. The risks 

associated with wastewater reuse and xenobiotics in the agroecological environment. Ecotoxic. 

and Env. Safe. In Press, Corrected Proof, Available online 1 May 2010. 

Fenlon, K.A., Johnson, A.C., Tyler, C.R., Hill, E.M. 2010. Gas-liquid chromatographytandem mass spectrometry methodology for the quantitation of estrogenic contaminants in bile 

of fish exposed to wastewater treatment works effluents and from wild populations. J. 

Chromatog. A 1217(1): 112-118. 

Fernandez, M.P., Campbell, P.M., Ikonomou, M.G., Devlin, R.H. 2007. Assessment of 

environmental estrogens and the intersex/sex reversal capacity for chinook salmon 

(Oncorhynchus tshawytscha) in primary and final municipal wastewater effluents. Environ. Int. 

33(3):391-6. 

Fernandez, M.P., Ikonomou, M.G., Buchanan, I. 2007. An assessment of estrogenic organic 

contaminants in Canadian wastewaters. Sci. Total Environ. 373(1): Pages 250-269. 

Ferrara, F., Ademollo, N., Delise, M., Fabietti, F., Funari, E. 2008. Alkylphenols and their 

ethoxylates in seafood from the Tyrrhenian Sea. Chemosphere 72(9): 1279-1285.

Fiedler, S., Foerster, M., Glaser, B., Zech, W. 2007. Alkylphenols in sediments of the Atlantic 

Rainforest south-west of São Paulo, Brazil. Chemosphere 66(2): 212-218.

Fifteenth International Symposium on Pollutant Responses in Marine Organisms (PRIMO15): 

Bordeaux, France 17–20 May 2009. Mar. Env. Res. 69(Suppl. 1): iii-xvi.

Fini, J.-B., Dolo, L., Cravedi, J.P., Demeneix, B., Zalko, D. 2009. Metabolism of the 

endocrine disruptor BPA by Xenopus laevis tadpoles. Ann. N. Y. Acad. Sci. 1163: 394-7. 

Fini, J.-B., Le Mevel, S., Turque, N., Palmier, K., Zalko, D., Cravedi, J.-P., Demeneix, B.A. 

2007. An In Vivo Multiwell-Based Fluorescent Screen for Monitoring Vertebrate Thyroid 

Hormone Disruption. Env. Sci. Tech. 41(16): 5908-5914. 

Finn, R.N. 2007. The physiology and toxicology of salmonid eggs and larvae in relation to 

water quality criteria. Aqua. Tox. 81(4): 337-354. 

Focazio, M.J., Kolpin, D.W., Barnes, K.K., Furlong, E.T., Meyer, M.T., Zaugg, S.D., Barber, 

L.B., Thurman, M.E. 2008. A national reconnaissance for pharmaceuticals and other organic 

wastewater contaminants in the United States — II) Untreated drinking water sources. Sci. 

Tot.Env. 402(2-3): 201-216.

Forbes, V.E., Aufderheide, J., Warbritton, R., van der Hoeven, N., Caspers, N. 2007. Does 

bisphenol A induce superfeminization in Marisa cornuarietis? Part II: Toxicity test results and 

requirements for statistical power analyses. Ecotox. Env. Saf. 66(3): 319-325. 
U.S. Environmental Protection Agency December 2010

10

Forbes, V.E., Aufderheide, J., Warbritton, R., van der Hoeven, N., Caspers, N. 2008. 

Superferminization as an effect of bisphenol A in Marisa cornuarietis -Response from Forbes 

et al. to Oehlmann et al. Ecotox. Env. Safety 69(3): 580-581. 

Forbes, V.E., Selck, H., Palmqvist, A., Aufderheide, J., Warbritton, R., Pounds, N., Thompson, 

R., van der Hoeven, N., Caspers, N. 2007. Does bisphenol A induce superfeminization in 

Marisa cornuarietis? Part I: Intra- and inter-laboratory variability in test endpoints. Ecotox. 

Env. Saf. 66(3): 309-318. 

Forbes, V.E., Warbritton, R., Aufderheide, J., Van Der Hoeven, N., Caspers, N. 2008. Effects 

of bisphenol A on fecundity, egg hatchability, and juvenile growth of Marisa cornuarietis. Env. 

Tox. Chem. 27(11): 2332-2340. 

Frouin, H., Lebeuf, M., Hammill, M., Masson, S., Fournier, M. 2010. Effects of individual 

polybrominated diphenyl ether (PBDE) congeners on harbour seal immune cells in vitro. Mar. 

Poll. Bull. 60(2): 291-298.

Fu, K.-Y., Chen, C.-Y., Chang, W.-M. 2007. Application of a yeast estrogen screen in nonbiomarker species Varicorhinus barbatulus fish with two estrogen receptor subtypes to assess 

xenoestrogens. Tox. in Vitro 21(4): 604-612. 

Fu, M., Li, Z., Gao, H. 2007. Distribution characteristics of nonylphenol in Jiaozhou Bay of 

Qingdao and its adjacent rivers. Chemos. 69(7): 1009-1016.

Gabriel, F.L., Cyris, M., Giger, W., Kohler, H.P. 2007. Ipso-substitution: a general 

biochemical and biodegradation mechanism to cleave alpha-quaternary alkylphenols and 

bisphenol A. Chem. Biodivers. 4(9):2123-37. 

Gadd, J.B., Tremblay, L.A., Northcott, G.L. 2010. Steroid estrogens, conjugated estrogens and 

estrogenic activity in farm dairy shed effluents. Env. Poll. 158(3): 730-736.

Gagnaire, B., Gagne, F., Andre, C., Blaise, C., Abbaci, K., Budzinski, H., Devier, M.-H., 

Garric, J. 2009. Development of biomarkers of stress related to endocrine disruption in 

gastropods: Alkali-labile phosphates, protein-bound lipids and vitellogenin-like proteins. Aqua. 

Tox. 92(3): 155-167. 

Gao, C.A., Zhang, A.Q., Lin, Y., Yin, D.Q., Wang, L.S. 2009. Quantitative structure-activity 

relationships of selected phenols with non-monotonic dose-response curves. Chinese Sci. Bull.

54(10): 1786-1796. 

Gasperi, J., Garaud, S., Rocher, V., Moilleron, R. 2008. Priority pollutants in wastewater and 

combined sewer overflow. Sci. Total Env. 407(1): 263-272.

George, O., Bryant, B.K., Chinnasamy, R., Corona, C., Arterburn, J.B., Shuster, C.B. 2008. 

Bisphenol A directly targets tubulin to disrupt spindle organization in embryonic and somatic 

cells. ACS Chem. Biol. 3(3): 167-179. 
U.S. Environmental Protection Agency December 2010

11

Giger, W., Gabriel, F.L., Jonkers, N., Wettstein, F.E., Kohler, H.P. 2009. Environmental fate 

of phenolic endocrine disruptors: field and laboratory studies. Philos. Transact. A Math. Phys. 

Eng. Sci. 367(1904): 3941-63. 

Gómez, M.J., Martínez Bueno, M.J., Lacorte, S., Fernández-Alba, A.R., Agüera, A. 2007. 

Pilot survey monitoring pharmaceuticals and related compounds in a sewage treatment plant 

located on the Mediterranean coast. Chemos. 66(6): 993-1002.

Goro Funakoshi, G., Shiro Kasuya, S. 2009. Influence of an estuary dam on the dynamics of 

bisphenol A and alkylphenols. Chemos. 75(4): 491-497. 

Greytak, S.R., Tarrant, A.M., Nacci, D., Hahn, M.E., Callard, G.V. 2010. Estrogen responses 

in killifish (Fundulus heteroclitus) from polluted and unpolluted environments are site- and 

gene- specific. Aqua. Tox. 99(2) 291-299.

Grung, M., Källqvist, T., Sakshaug, S., Skurtveit, S., Thomas, K.V. 2008. Environmental 

assessment of Norwegian priority pharmaceuticals based on the EMEA guideline. Ecotox. Env. 

Saf. 71(2): 328-340.

Gunnarsson, L., Adolfsson-Erici, M., Björlenius, B., Rutgersson, C., Förlin, L., Larsson, D.G.J. 

2009. Comparison of six different sewage treatment processes—Reduction of estrogenic 

substances and effects on gene expression in exposed male fish. Sci. Total Env. 407(19): 5235-

5242. 

Guo, N., Xie, P. 2009. The toxic effects of BPA and NP on D. carinata and M. micrura 

Shuisheng Shengwu Xuebao, 33(3): 492-497. 

Gust, M., Buronfosse, T., Giamberini, L., Ramil, M., Mons, R., Garric, J. 2009. Effects of 

fluoxetine on the reproduction of two prosobranch mollusks: Potamopyrgus antipodarum and 

Valvata piscinalis. Env. Poll. 157(2): 423-429.

Gust, M., Garric, J., Giamberini, L., Mons, R., Abbaci, K., Garnier, F., Buronfosse, T. 2010. 

Sensitivity of New Zealand mudsnail Potamopyrgus antipodarum (Gray) to a specific 

aromatase inhibitor. Chemos. 79(1): 47-53. 

Gutiérrez, S., Fernandez, C., Barata, C., Tarazona, J.V. 2009. Forecasting risk along a river 

basin using a probabilistic and deterministic model for environmental risk assessment of 

effluents through ecotoxicological evaluation and GIS. Sci. Total Env. 408(2): 294-303.

Gyllenhammar, I., Holm, L., Eklund, R., Berg, C. 2009. Reproductive toxicity in Xenopus 

tropicalis after developmental exposure to environmental concentrations of ethynylestradiol. 

Aqua. Tox. 91(2): 171-178. 
U.S. Environmental Protection Agency December 2010

12

Ha, M.-H., Choi, J. 2009. Effects of Environmental Contaminants on Hemoglobin Gene 

Expression in Daphnia magna: A Potential Biomarker for Freshwater Quality Monitoring. 

Arch. Env. Contam. Tox. 57(2): 330-337. 

Ha, M.-H., Choi, J. 2008. Chemical-induced alteration of hemoglobin expression in the 4th 

instar larvae of Chironomus tentans Mg. (Diptera: Chironomidae). Env. Tox. Pharma. 25(3): 

393-398. 

Ha, M.-H., Choi, J. 2008. Effects of environmental contaminants on hemoglobin of larvae of 

aquatic midge, Chironomus riparius (Diptera: Chironomidae): a potential biomarker for 

ecotoxicity monitoring. Chemos. 71(10):1928-36. 

Hala, D., Bristeau, S., Dagnac, T., Jobling, S. 2010. The unexpected sources of organotin 

contamination in aquatic toxicological laboratory studies. Aqua. Tox. 96(4): 314-318. 

Hall, L.C., Okihiro, M., Johnson, M.L., The, S.J. 2007. SurflanTM and oryzalin impair 

reproduction in the teleost medaka (Oryzias latipes). Mar. Env. Res. 63(2): 115-131. 

Hampel, M., Moreno-Garrido, I., González-Mazo, E., Blasco, E. 2009. Suitability of the 

marine prosobranch snail Hydrobia ulvae for sediment toxicity assessment: A case study with 

the anionic surfactant linear alkylbenzene sulphonate (LAS). Ecotox. Env. Saf. 72(4): 1303-

1308. 

Han, J., Fang, Z. 2010. Estrogenic effects, reproductive impairment and developmental 

toxicity in ovoviparous swordtail fish (Xiphophorus helleri) exposed to perfluorooctane 

sulfonate (PFOS). Aqua. Tox. 99(2):281-290.

Hao, R., Li, J., Zhou, Y., Cheng, S., Zhang, Y. 2009. Structure–biodegradability relationship 

of nonylphenol isomers during biological wastewater treatment process. Chemos. 75(8): 987-

994. 

Harris, C.A., Brian, J.V., Pojana, G., Lamoree, M., Booy, P., Marcomini, A., Sumpter, J.P. 

2009. The influence of a surfactant, linear alkylbenzene sulfonate, on the estrogenic response 

to a mixture of (xeno)estrogens in vitro and in vivo. Aqua. Tox. 91(1): 95-98.

Hashimoto, K., Nakajima, Y., Matsumura, S., Chatani, F. 2010. An in vitro micronucleus 

assay with size-classified micronucleus counting to discriminate aneugens from clastogens. 

Tox. in Vitro 24(1): 208-216. 

Hayashi, H., Nishimoto, A., Oshima, N., Iwamuro, S. 2007. Expression of the estrogen 

receptor alpha gene in the anal fin of Japanese medaka, Oryzias latipes, by environmental 

concentrations of bisphenol A. J. Tox. Sci. 32(1): 91-96. 

He, Y., Wiseman, S.B., Zhang, X., Hecker, M., Jones, P.D., El-Din, M.G., Martin, J.W., Giesy 

J.P. 2010. Ozonation attenuates the steroidogenic disruptive effects of sediment free oil sands 

process water in the H295R cell line. Chemos. 80(5): 578-584.
U.S. Environmental Protection Agency December 2010

13

Heath, E., Kosjek, T., Andersen, H.R., Lützhøft, H.-C.H., Erici, M.A., Coquery, M., Düring, 

R.-A., Gans, O., Guignard, C., Karlsson, P., Manciot, F., Moldovan, Z., Patureau, D., Cruceru, 

L., Sacher, F., Ledin, A. 2010. Inter-laboratory exercise on steroid estrogens in aqueous 

samples. Env. Poll. 158(3): 658-662.

Heimeier, R.A., Das, B., Buchholz, D.R., Shi, Y.-B. 2009. The xenoestrogen bisphenol A 

inhibits postembryonic vertebrate development by antagonizing gene regulation by thyroid 

hormone. Endoc. 150(6): 2964-2973. 

Henry, T. B., McPherson, J. T., Rogers, E. D., Heah, T. P., Hawkins, S. A., Layton, A. C., 

Sayler, G. S. 2009. Changes in the relative expression pattern of multiple vitellogenin genes in 

adult male and larval zebrafish exposed to exogenous estrogens. Compar. Biochem. Physiol., 

Pt A: Mol. Integ. Physiol. 154A(1): 119-126. 

Hernández-Rodríguez, G., Zumbado, M., Luzardo, O.P., Monterde, J.G., Blanco, A., Boada, 

L.D. 2007. Multigenerational study of the hepatic effects exerted by the consumption of 

nonylphenol- and 4-octylphenol-contaminated drinking water in Sprague–Dawley rats. Env. 

Tox. Pharm. 23(1): 73-81. 

Hillwalker, W.E., Allan, S.E., Tanguay, R.L., Anderson, K.A. 2010. Exploiting lipid-free 

tubing passive samplers and embryonic zebrafish to link site specific contaminant mixtures to 

biological responses. Chemos. 79(1): 1-7.

Holth, T.F., Nourizadeh-Lillabadi, R., Blaesbjerg, M., Grung, M., Holbech, H., Petersen, G.I., 

Aleström, P., Hylland, K. 2008. Differential gene expression and biomarkers in zebrafish 

(Danio rerio) following exposure to produced water components. Aqua. Tox. 90(4): 277-291.

Hong, S., Shin, K.-H. 2009. Alkylphenols in the core sediment of a waste dumpsite in the East 

Sea (Sea of Japan), Korea. Mar. Poll. Bull. 58(10): 1566-1571.

Hong, S., Won, E.-J., Ju, H.-J., Kim, M.-S., Shin, K.-H. 2010. Current nonylphenol pollution 

and the past 30 years record in an artificial Lake Shihwa, Korea. Mar. Poll. Bull. 60(2): 308-

313. 

Hong, S.H., Munschy, C., Kannan, N., Tixier, C., Tronczynski, J., Héas-Moisan, K., Shim, W.J. 

2009. PCDD/F, PBDE, and nonylphenol contamination in a semi-enclosed bay (Masan Bay, 

South Korea) and a Mediterranean lagoon (Thau, France). Chemos. 77(6): 854-862. 

Honkanen, J.O., Wiegand, C., Kukkonen, J.V.K. 2008. Humic substances modify 

accumulation but not biotransformation of pyrene in salmon yolk-sac fry. Aqua. Tox. 86(2): 

239-248.

Horii, Y., Reiner, J.L., Loganathan, B.G., Kumar, K.S., Sajwan, K., Kannan, K. 2007. 

Occurrence and fate of polycyclic musks in wastewater treatment plants in Kentucky and 

Georgia, USA. Chemos. 68(11): 2011-2020. 
U.S. Environmental Protection Agency December 2010

14

Houtman, C.J., Leonards, P.E.G., Kapiteijn, W., Bakker, J.F., Brouwer, A., Lamoree, M.H., 

Legler, J., Klamer, H.J.C. 2007. Sample preparation method for the ER-CALUX bioassay 

screening of (xeno-)estrogenic activity in sediment extracts. Sci. Total Env. 386 (1-3): 134-144. 

Hu, G., Jin, M., Lin, X., Guo, C., Zhang, L., Sun, Z. 2010. Mercury distribution in neonatal rat 

brain after intrauterine methylmercury exposure. Env. Toxic. Pharm. 29(1): 7-11.

Hu, S., Shen, G., Zhao, Q. 2007. Study on immunotoxicity of bisphenol A to lymphocytes and 

macrophages of Carassius auratus following in vitro exposure. Shanghai Huanjing Kexue

26(2): 71-76. 

Huang, C., Zhang, Z., Wu, S., Zhao, Y., Hu, J. 2010. In vitro and in vivo estrogenic effects of 

17α-estradiol in medaka (Oryzias latipes). Chemos. 80(5): 608-612.

Huang, P.-C., Tien, C.-J., Sun, Y.-M., Hsieh, C.-Y., Lee, C.-C. 2008. Occurrence of phthalates 

in sediment and biota: Relationship to aquatic factors and the biota-sediment accumulation 

factor. Chemos. 73(4): 539-544.

Huang, Y., Ren, H., Sun, Z.-Y., Zhou Z.-L. 2008. Vitellogenin mRNA expression in male 

zebrafish (Danio rerio) induced by nonylphenol and bisphenol-A. Asian J. Ecotox. 3(3): 274-

279. 

Huo, C. X., Hickey, P. 2007. EDC demonstration programme in the UK Anglian Water's 

approach. Env. Tech. 28(7): 731-741. 

Hutchinson, T.H., Bögi, C., Winter, M.J., Owens, J.W. 2009. Benefits of the maximum 

tolerated dose (MTD) and maximum tolerated concentration (MTC) concept in aquatic 

toxicology. Aqua. Tox. 91(3): 197-202.

Hwang, D.-S., Lee, J.-S., Rhee, J.-S., Han, J., Lee, Y.-M., Kim, I.-C., Park, G.S., Lee, J., Lee, 

J.-S. 2009. Modulation of p53 gene expression in the intertidal copepod Tigriopus japonicus

exposed to alkylphenols. Mar. Env. Res. 69(Suppl. 1): S77-S89.

Hwang, G.S. 2007. Acute toxicity of bisphenol A to the crustacean Daphnia magna. Hangug 

Hwangyeong Bogeon Haghoeji 33(5): 392-396. 

Ishibashi, H., Yamauchi, R., Matsuoka, M., Kim, J.-W., Hirano, M., Yamaguchi, A., Tominaga, 

N., Arizono, K. 2008. Fluorotelomer alcohols induce hepatic vitellogenin through activation of 

the estrogen receptor in male medaka (Oryzias latipes). Chemos. 71(10): 1853-1859.

Isobe, T., Takada, H., Kanai, M., Tsutsumi, S., Isobe, K.O., Boonyatumanond, R., Zakaria, 

M.P. 2007. Distribution of polycyclic aromatic hydrocarbons (PAHs) and phenolic endocrine 

disrupting chemicals in south and southeast Asian mussels. Env. Monit. Assess. 135(1-3): 423-

440. 
U.S. Environmental Protection Agency December 2010

15

Izumi, N., Yanagibori, R., Shigeno, S., Sajiki, J. 2008. Effects of bisphenol A on the 

development, growth, and sex ratio of the housefly Musca domestica. Env. Toxic. Chem. 27(6): 

1343-1353. 

Jackson, J., Sutton, R. 2008. Sources of endocrine-disrupting chemicals in urban wastewater, 

Oakland, CA. Sci. Total Env. 405(1-3): 153-160.

Jao, B., Yeung, E.K.C., Chan, C.B., Cheng, C.H.K. 2008. Establishment of a Transgenic Yeast 

Screening System for Estrogenicity and Identification of the Anti-Estrogenic Activity of 

Malachite Green. J. Cell. Biochem. 105(6): 1399-1409. 

Jeffries, K.M., Nelson, E.R., Jackson, L.J., Habibi, H.R. 2008. Basin-wide impacts of 

compounds with estrogen-like activity on longnose dace (Rhinichthys cataractae) in two prairie 

rivers of Alberta, Canada. Env. Tox. Chem. 27(10): 2042-2052. 

Ji, L., Wang, X.D., Yang, X.S., Liu, S.S., Wang, L.S. 2008. Back-propagation network 

improved by conjugate gradient based on genetic algorithm in QSAR study on endocrine 

disrupting chemicals. Chinese Sci Bull. 53(1): 33-39. 

Jiao, S., Zheng, S., Yin, D., Wang, L., Chen, L. 2008. Aqueous photolysis of tetracycline and 

toxicity of photolytic products to luminescent bacteria. Chemos. 73(3): 377-382. 

Jiao, S., Zheng, S., Yin, D., Wang, L., Chen, L. 2009. Aqueous oxytetracycline degradation 

and the toxicity change of degradation compounds in photoirradiation process. J. Env. Sci.

20(7): 806-813. 

Jin, S., Yang, F., Liao, T., Hui, Y., Xu, Y. 2008. Seasonal variations of estrogenic compounds 

and their estrogenicities in influent and effluent from a municipal sewage treatment plant in 

China. Env. Tox. Chem. 27(1): 146-153. 

Jin, Y., Chen, R., Sun, L., Wang, W., Zhou, L., Liu, W., Fu, Z. 2009. Enantioselective 

induction of estrogen-responsive gene expression by permethrin enantiomers in embryo-larval 

zebrafish. Chemos. 74(9): 1238-1244. 

Jin, Y., Wang, W., Xu, C., Fu, Z., Liu, W. 2008. Induction of hepatic estrogen-responsive 

gene transcription by permethrin enantiomers in male adult zebrafish. Aqua. Tox. 88(2): 146-

152. 

Jing-jing, M., Lu-qing, P., Jing, L., Lin, Z. 2009. Effects of benzo[a]pyrene on DNA damage 

and histological alterations in gonad of scallop Chlamys farreri. Mar. Env. Res., 67(1): 47-52. 

Johnson, L.L., Lomax, D.P., Myers, M.S., Olson, O.P., Sol, S.Y., O’Neill, S.M., West, J., 

Collier, T.K. 2008. Xenoestrogen exposure and effects in English sole (Parophrys vetulus) 

from Puget Sound, WA. Aqua. Tox. 88(1): 29-38.
U.S. Environmental Protection Agency December 2010

16

Jolly, C., Katsiadaki, I., Morris, S., Le Belle, N., Dufour, S., Mayer, I., Pottinger, T.G., Scott, 

A. P. 2009. Detection of the anti-androgenic effect of endocrine disrupting environmental 

contaminants using in vivo and in vitro assays in the 3-spined stickleback. Aqua. Tox. 92(4): 

228-239. 

Jonkers, N., Kohler, H.P., Dammshäuser, A., Giger, W. 2009. Mass flows of endocrine 

disruptors in the Glatt River during varying weather conditions. Env. Poll. 157(3):714-23. 

Jonkers, N., Sousa, A., Galante-Oliveira, S., Barroso, C.M., Kohler, H.P., Giger, W. 2010. 

Occurrence and sources of selected phenolic endocrine disruptors in Ria de Aveiro, Portugal. 

Env. Sci. Pol. Res. Int. 17(4):834-43. 

Jonsson, G., Stokke, T.U., Cavcic, A., Jørgensen, K.B., Beyer, J. 2008. Characterization of 

alkylphenol metabolites in fish bile by enzymatic treatment and HPLC-fluorescence analysis. 

Chemos. 71(7): 1392-1400. 

Jugan, M.L., Oziol, L., Bimbot, M., Huteau, V., Tamisier-Karolak, S., Blondeau, J.P., Lévi, Y. 

2009. In vitro assessment of thyroid and estrogenic endocrine disruptors in wastewater 

treatment plants, rivers and drinking water supplies in the greater Paris area (France). Sci. Total 

Env. 407(11): 3579-3587. 

Jukosky, J.A., Watzin, M.C., Leiter, J.C. 2008. The effects of environmentally relevant 

mixtures of estrogens on Japanese medaka (Oryzias latipes) reproduction. Aqua. Tox. 86(2): 

323-331. 

Kang, I.J., Yokota, H., Oshima, Y., Tsuruda, Y., Shimasaki, Y, Honjo, T. 2008. The effects of 

methyltestosterone on the sexual development and reproduction of adult medaka (Oryzias 

latipes). Aqua. Tox. 87(1): 37-46. 

Kang, J.-H., Aasi, D., Katayama, Y. 2007. Bisphenol A in the aquatic environment and its 

endocrine-disruptive effects on aquatic organisms. Crit. Rev. Tox. 37(7): 607-625. 

Kang, J.-H., Aasi, D., Katayama, Y. 2008. Bisphenol A in the aquatic environment and its 

endocrine-disruptive effects on aquatic organisms. [Erratum to 2007 citation]. Crit. Rev. in Tox. 

38(2): 171. 

Kausch, U., Alberti, M., Haindl, S., Budczies, J., Hock, B. 2008. Biomarkers for exposure to 

estrogenic compounds: Gene expression analysis in zebrafish (Danio rerio). Env. Tox. 23(1): 

15-24. 

Keri, R.A., Ho, S.M., Hunt, P.A., Knudsen, K.E., Soto, A.M., Prins, G.S. 2007. An evaluation 

of evidence for the carcinogenic activity of bisphenol A. Repro. Tox. 24(2):240-52. 

Kim, H.N., Park, K.S., Lee, S.K., Gu, M.B. 2008. Gene expression characteristics in the 

Japanese Medaka (Oryzias latipes) liver after exposure to endocrine disrupting chemicals. 

Advanced Environmental Monitoring, Springer, Netherlands: 338-347. 
U.S. Environmental Protection Agency December 2010

17

Kim, K.-T., Lee, C., Kim, E.-K., Park, Y.-R., Moon, Y. R., Ryu, J., Kim, H.-M., Kim, H.-J., 

Choi, K. 2007. Framework development for environmental hazard assessment of endocrine 

disruptors using crustacean Daphnia. Mol. Cell. Tox. 3(4) Suppl. S: 57. 

Kinani, S., Bouchonnet, S., Creusot, N., Bourcier, S., Balaguer, P., Porcher, J.-M., Ait-Aissa, S. 

2010. Bioanalytical characterisation of multiple endocrine- and dioxin-like activities in 

sediments from reference and impacted small rivers. Env. Poll. 158(1): 74-83. 

Kishi, K., Kitagawa, E., Iwahashi, H., Ippongi, T., Kawauchi, H., Nakazono, K., Inoue, M., 

Ohba, H., Hayashi, Y. 2008. Expression analysis of sex-specific and endocrine-disruptorsresponsive genes in Japanese medaka, Oryzias latipes, using oligonucleotide microarrays. 

Advanced Environmental Monitoring. Springer, Netherlands: 363-375. 

Kitada, Y., Kawahata, H., Suzuki, A., Oomori, T. 2008. Distribution of pesticides and 

bisphenol A in sediments collected from rivers adjacent to coral reefs. Chemos. 71(11): 2082-

2090. 

Klecka, G.M., Staples, C.A., Clark, K.E., Van der Hoeven, N., Thomas, D.E., Hentges, S.G. 

2009. Exposure analysis of bisphenol A in surface water systems in North America and 

Europe. Env. Sci. Tech. 43(16): 6145-50. 

Kobayashi, J., Sakai, M., Kajihara, H., Takahashi, Y. 2008. Temporal trends and sources of 

PCDD/Fs, pentachlorophenol and chlornitrofen in paddy field soils along the Yoneshiro River 

basin, Japan. Env. Poll. 156(3): 1233-1242.

Koffi T. Tassou, K.T., Ralf Schulz, R. 2009. Effects of the insect growth regulator 

pyriproxyfen in a two-generation test with Chironomus riparius. Ecotox. Env. Saf. 72(4): 1058-

1062.

Kohno, S., Bermudez, D.S., Katsu, Y., Iguchi, T., Guillette Jr., L.J. 2008. Gene expression 

patterns in juvenile American alligators (Alligator mississippiensis) exposed to environmental 

contaminants. Aqua. Tox. 88(2): 95-101.

Koponen, P.S., Tuikka, A., Kukkonen, J.V. 2007. Effects of ultraviolet-B radiation and larval 

growth on toxicokinetics of waterborne bisphenol A in common frog (Rana temporaria) larvae. 

Chemos. 66(7):1323-8. 

Kortner, T.M., Vang, S.-H., Arukwe, A. 2009. Modulation of salmon ovarian steroidogenesis 

and growth factor responses by the xenoestrogen, 4-nonylphenol. Chemos. 77(7): 989-998. 

Koukouzika, N., Dimitriadis, V.K. 2008. Aspects of the usefulness of five marine pollution 

biomarkers, with emphasis on MN and lipid content. Mar. Poll. Bull. 56(5): 941-949.

Kovalishyn, V.V., Kholodovych, V., Tetko, I.V., Welsh, W.J. 2007. Volume learning 

algorithm significantly improved PLS model for predicting the estrogenic activity of 

xenoestrogens. J. Mol. Graph. Model. 26(2): 591-594. 
U.S. Environmental Protection Agency December 2010

18

Kuiper, R.V., Cantón, R.F., Leonards, P.E.G., Jenssen, B.M., Dubbeldam, M., Wester, P.W., 

van den Berg, M., Vos, J.G., Vethaak, A.D. 2007. Long-term exposure of European flounder 

(Platichthys flesus) to the flame-retardants tetrabromobisphenol A (TBBPA) and 

hexabromocyclododecane (HBCD). Ecotox. Env. Saf. 67(3): 349-360. 

Kungolos, A, Ed., Zamorano, M., Ed. 2008. WIT transactions on ecology and the 

environment. Wessex Inst. Technol., WIT Press, Ashurst, UK. 

Lamoree, M. H., Derksen, J. G. M., van der Linden, S. C., Uijterlinde, C. A., de Voogt, P. 

2010. Efficiency of Removal of Compounds with Estrogenic Activity During Wastewater 

Treatment: Effects of Various Removal Techniques. Xenobiotics in the Urban Water Cycle: 

Mass Flows, Environmental Processes, Mitigation and Treatment Strategies. Netherlands. 

Series: Environmental Pollution-Series: 261-282. 

Latorre, A., Malmqvist, A., Lacorte, S., Welander, T., Barceló, D. 2007. Evaluation of the 

treatment efficiencies of paper mill whitewaters in terms of organic composition and toxicity. 

Env. Poll. 147(3): 648-655.

Lee, B.L., Choi, J. 2007. Effects of bisphenol A and ethynyl estradiol exposure on enzyme 

activities, growth and development in the fourth instar larvae of Chironomus riparius (Diptera, 

Chironomidae). Ecotox. Env. Saf. 68(1): 84-90. 

Lee, C., Park, M.-K., Kim, H.-M., Kim, H.-J., Choi, K. 2007. Expression of estrogenresponsive genes by short-term exposure to bisphenol A in wild medaka fish (Oryzias sinensis). 

Mol. Cell. Tox. 3,(4) Suppl. S: 56. 

Lee, C., Park, M.-K., Kim, H.-M., Kim, H.-J., Choi, K. 2007. The expression patterns of 

estrogen-responsive genes by bisphenol a in the wild medaka (Oryzias sinensis). Mol. Cell. Tox.

3(3): 185-189. 

Lee, J., Lee, B.C., Ra, J.S., Cho, J., Kim, I.S., Chang, N.I., Kim, H.K., Kim, S.D. 2008. 

Comparison of the removal efficiency of endocrine disrupting compounds in pilot scale sewage 

treatment processes. Chemos. 71(8): 1582-1592. 

Lee, K.-W., Raisuddin, S., Hwang, D.-S., Park, H. G., Lee, J.-S. 2007. Acute Toxicities of 

trace metals and common Xenobiotics to the marine copepod Tigriopus japonicus: Evaluation 

of its use as a benchmark species for routine ecotoxicity tests in Western Pacific coastal 

regions. Env. Tox. 22(5): 532-538. 

Lee, S.-B., Choi, J. 2007. Effects of bisphenol A and ethynyl estradiol exposure on enzyme 

activities, growth and development in the fourth instar larvae of Chironomus riparius (Diptera, 

Chironomidae). Ecotox. Env. Saf. 68(1): 84-90. 
U.S. Environmental Protection Agency December 2010

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Lee, S.-W., Choi, J. 2009. Multi-level ecotoxicity assay on the aquatic midge, Chironomus 

tentans (Diptera, Chironomidae) exposed to octachlorostyrene. Env. Tox. Pharm. 28(2): 269-

274. 

Lee, Y.-M., Lee, K.-W., Park, H., Park, H.G., Raisuddin, S., Ahn, I.-Y., Lee, J.-S. 2007. 

Sequence, biochemical characteristics and expression of a novel Sigma-class of glutathione Stransferase from the intertidal copepod, Tigriopus japonicus with a possible role in antioxidant 

defense. Chemos. 69(6): 893-902. 

Lee, Y.-M., Raisuddin, S., Rhee, J.-S., Ki, J.-S., Kim, I.-C., Lee, J.-S. 2008. Modulatory effect 

of environmental endocrine disruptors on N-ras oncogene expression in the hermaphroditic fish, 

Kryptolebias marmoratus. Compar. Biochem. Physiol. Part C: Tox. Pharmac. 147C(3): 299-

305. 

Lee, Y.-M., Rhee, J.-S., Hwang, D.-S., Kim, I.-C., Raisuddin, S., Lee, J.-S. 2007. Mining of 

biomarker genes from expressed sequence tags and differential display reverse transcriptasepolym erase chain reaction in the self-fertilizing fish, Kryptolebias marmoratus and their 

expression patterns in response to exposure to an endocrine-disrupting alkylphenol, bisphenol 

A. Mol. Cells 23(3): 287-303. 

Lee, Y.-M., Rhee, J.-S., Hwang, D.-S., Kim, I.-C., Raisuddin, S., Lee, J.-S. 2008. p53 gene 

expression is modulated by endocrine disrupting chemicals in the hermaphroditic fish, 

Kryptolebias marmoratus. Compar. Biochem.Physiol. Part C: Tox. Pharma. 147C(2): 150-157. 

Leech, D.M., Snyder, M.T., Wetzel, R.G. 2009. Natural organic matter and sunlight accelerate 

the degradation of 17ß-estradiol in water. Sci. Total Env. 407(6): 2087-2092. 

Legler, J. 2008. New insights into the endocrine disrupting effects of brominated flame 

retardants. Chemos. 73(2): 216-222.

Legler, J., de Boer, J. 2007. Combining analytical chemistry and toxicology to trace 

environmental contaminants: the start of a beautiful friendship. Preprints of Extended Abstracts 

presented at the ACS National Meeting, American Chemical Society, Division of 

Environmental Chemistry 47(2): 551-555. 

Lei, B., Huang, S., Zhou, Y., Wang, D., Wang, Z. 2009. Levels of six estrogens in water and 

sediment from three rivers in Tianjin area, China. Chemos. 76(1): 36-42.

Lei, X., Li, Z.-Q., Lian, Z.-M., Lian, Z.-L., Bai, C.-Y. 2009. Acute toxicity effects of 

bisphenol A and p-nitrophenol to Misgurnus anguillicadatus. Shengtaixue Zazhi 28(11): 2257-

2261. 

Lemos, M.F.L., Esteves, A.C., Samyn, B., Timperman, I., van Beeumen, J., Correia, A., van 

Gestel, C.A.M., Soares, A.M.V.M. 2010. Protein differential expression induced by endocrine 

disrupting compounds in a terrestrial isopod. Chemos. 79(5): 570-576. 
U.S. Environmental Protection Agency December 2010

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Lemos, M.F.L., van Gestel, C.A.M., Soares, A.M.V.M. 2009. Endocrine disruption in a 

terrestrial isopod under exposure to bisphenol A and vinclozolin. J. Soils Sedim. 9(5): 492-500. 

Lemos, M.F.L., van Gestel, C.A.M., Soares, A.M.V.M. 2010. Reproductive toxicity of the 

endocrine disrupters vinclozolin and bisphenol A in the terrestrial isopod Porcellio scaber

(Latreille, 1804). Chemos. 78(7): 907-913. 

Leroy, D., Haubruge, E., De Pauw, E., Thomé, J.P., Francis, F. 2010. Development of 

ecotoxicoproteomics on the freshwater amphipod Gammarus pulex: Identification of PCB 

biomarkers in glycolysis and glutamate pathways. Ecotox. Env. Saf. 73(3): 343-352. 

Li, D., Dong, M., Shim, W.J., Yim, U.H., Hong, S.H., Kannan, N. 2008. Distribution 

characteristics of nonylphenolic chemicals in Masan Bay environments, Korea. Chemos. 71(6): 

1162-1172. 

Li, F.B., Li, X.Z., Liu, C.S., Liu, T.X. 2007. Effect of alumina on photocatalytic activity of 

iron oxides for bisphenol A degradation. J. Hazard. Mater. 149(1):199-207. 

Li, J., Zhou, B., Liu, Y., Yang, Q., Cai, W. 2008. Influence of the coexisting contaminants on 

bisphenol A sorption and desorption in soil. J. Hazard. Mater. 151(2-3):389-93. 

Li, R., Chen, G.Z., Tam, N.F., Luan, T.G., Shin, P.K., Cheung, S.G., Liu, Y. 2009. Toxicity of 

bisphenol A and its bioaccumulation and removal by a marine microalga Stephanodiscus 

hantzschii. Ecotox. Env. Saf. 72(2): 321-8. 

Li, R., Liu, Y., Chen, G., Tam, N.F.Y., Shin, P.K.S., Cheung, S.G., Luan, T. 2008. 

Physiological responses of the alga Cyclotella caspia to bisphenol A exposure. Bot. Marina

51(5): 360-369. 

Li, X., Lin, L., Luan, T., Yang, L., Lan, C. 2008. Effects of landfill leachate effluent and 

bisphenol A on glutathione and glutathione-related enzymes in the gills and digestive glands of 

the freshwater snail Bellamya purificata. Chemos. 70(10): 1903-1909. 

Li, X.L., I, Luan, T.-G., Liang, Y., Wong, M.-H., Lan, C.-Y. 2007. Distribution patterns of 

octylphenol and nonylphenol in the aquatic system at Mai Po Marshes Nature Reserve, a 

subtropical estuarine wetland in Hong Kong. J. of Env. Sci. 19(6): 657-662.

Li, Y., Zhou, Q., Li, F., Liu, X., Luo, Y. 2008. Effects of tetrabromobisphenol A as an 

emerging pollutant on wheat (Triticum aestivum) at biochemical levels. Chemos. 74(1): 119-

124.

Li, Z.-H., Li, P., Rodina, M., Randak, T. 2010. Effect of human pharmaceutical 

Carbamazepine on the quality parameters and oxidative stress in common carp (Cyprinus 

carpio L.) spermatozoa. Chemos. 80(5): 530-534. 
U.S. Environmental Protection Agency December 2010

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Liao, C.-S., Chen, L.-C., Chen, B.-S., Lin, S.-H. 2010. Bioremediation of endocrine disruptor 

di-n-butyl phthalate ester by Deinococcus radiodurans and Pseudomonas stutzeri. Chemos. 

78(3): 342-346. 

Liedtke, A., Muncke, J., Ruefenacht, K., Eggen, R.I.L. 2008. Molecular multi-effect screening 

of environmental pollutants using the MolDarT. Env. Tox. 23(1): 59-67. 

Liedtke, A., Schonenberger, R., Eggen, R.I.L., Suter, M.J.-F. 2009. Internal exposure of 

whitefish (Coregonus lavaretus) to estrogens. Aqua. Tox. 93(2-3): 158-165. 

Lim, D.S., Kwack, S.J., Kim, K.B., Kim, H.S., Lee, B.M. 2009. Risk assessment of bisphenol 

A migrated from canned foods in Korea. J. Tox. Env. Health A 72(21-22): 1327-35. 

Lin, Y., Shi, Y., Jiang, M., Jin, Y., Peng, Y., Lu, B., Dai, K. 2008. Removal of phenolic 

estrogen pollutants from different sources of water using molecularly imprinted polymeric 

microspheres. Env. Poll. 153(2): 483-491. 

Liscio, C., Magi, E., Di Carro, M., Suter, M. J. -F., Vermeirssen, E. L. M. 2009. Combining 

passive samplers and biomonitors to evaluate endocrine disrupting compounds in a wastewater 

treatment plant by LC/MS/MS and bioassay analyses. Env. Pol. 157(10): 2716-2721. 

Lithner, D., Damberg, J., Dave, G., Larsson, Å. 2009. Leachates from plastic consumer 

products – Screening for toxicity with Daphnia magna. Chemos. 74(9): 1195-1200. 

Liu, C., Du, Y., Zhou, B. 2007. Evaluation of estrogenic activities and mechanism of action of 

perfluorinated chemicals determined by vitellogenin induction in primary cultured tilapia 

hepatocytes. Aqua. Tox. 85(4): 267-277.

Liu, G., Zheng, S., Xing, X., Li, Y., Yin, D., Ding, Y., Pang, W. 2010. Fe(III)–oxalate 

complexes mediated photolysis of aqueous alkylphenol ethoxylates under simulated sunlight 

conditions. Chemos. 78(4): 402-408.

Liu, H., Papa, E., Gramatica, P. 2008. Evaluation and QSAR modeling on multiple endpoints 

of estrogen activity based on different bioassays. Chemos. 70(10): 1889-1897. 

Liu, H., Papa, E., Walker, J.D., Gramatica, P. 2007. In silico screening of estrogen-like 

chemicals based on different nonlinear classification models. J. Mol. Graph. Model. 26(1): 135-

144. 

Liu, H.-L., Liu, X.-H., Wang, X.-Y., Wang, X.-R., Yu, H.-X. 2007. Toxicity of BPA and 

TBBPA to Daphnia magna and zebrafish (Brachydanio rerio). Huanjing Kexue 28(8): 1784-

1787. 
U.S. Environmental Protection Agency December 2010

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Liu, T.-A., Shakhawat, B., Snow, R., Yasuda, S., Yasuda, T., Yang, Y.-S., Williams, F.E., Liu, 

M.-Y., Suiko, M., Carter, G., Liu, M.-C. 2008. Identification and characterization of two novel 

cytosolic sulfotransferases, SULT1 ST7 and SULT1 ST8, from zebrafish. Aqua. Tox. 89(2): 94-

102.

Liu, Y., Guan, Y., Gao, Q., Tam, N.F.Y., Zhu, W. 2010. Cellular responses, biodegradation 

and bioaccumulation of endocrine disrupting chemicals in marine diatom Navicula incerta. 

Chemos. 80 (5): 592-599.

Loos, R., Hanke, G., Umlauf, G., Eisenreich, S.J. 2007. LC–MS–MS analysis and occurrence 

of octyl- and nonylphenol, their ethoxylates and their carboxylates in Belgian and Italian textile 

industry, waste water treatment plant effluents and surface waters. Chemos. 66(4): 690-699. 

Lopez-Espinosa, M.J., Freire, C., Arrebola, J.P., Navea, N., Taoufiki, J., Fernandez, M.F., 

Ballesteros, O., Prada, R., Olea, N. 2009. Nonylphenol and octylphenol in adipose tissue of 

women in Southern Spain. Chemos. 76(6): 847-852. 

Lougheed, T. 2009. Outside looking in: understanding the role of science in regulation. Env. 

Health Perspect. 117(3): A104-10. 

Louiz, I., Kinani, S., Gouze, M.-E., Ben-Attia, M., Menif, D., Bouchonnet, S., Porcher, J.M., 

Ben-Hassine, O.K., Aït-Aïssa, S. 2008. Monitoring of dioxin-like, estrogenic and antiandrogenic activities in sediments of the Bizerta lagoon (Tunisia) by means of in vitro cellbased bioassays: Contribution of low concentrations of polynuclear aromatic hydrocarbons 

(PAHs). Sci.Total Env. 402(2-3): 318-329. 

Lozano, N., Rice, C.P., Ramirez, M., Torrents, A. 2010. Fate of triclosan in agricultural soils 

after biosolid applications. Chemos. 78(6): 760-766.

Lundström, E., Björlenius, B., Brinkmann, M., Hollert, H., Persson, J.-O., Breitholtz, M. 2010. 

Comparison of six sewage effluents treated with different treatment technologies—Population 

level responses in the harpacticoid copepod Nitocra spinipes. Aqua. Tox. 96(4): 298-307. 

Lv, X., Zhou, Q., Song, M., Jiang, G., Shao, J. 2007. Vitellogenic responses of 17 betaestradiol and bisphenol A in male Chinese loach (Misgurnus anguillicaudatus). Env. Tox. 

Pharm. 24(2): 155-159. 

Mäenpää, K., Leppänen, M.T., Kukkonen, J.V.K. 2009. Sublethal toxicity and 

biotransformation of pyrene in Lumbriculus variegatus (Oligochaeta). Sci. Total Env. 407(8): 

2666-2672. 

Mandich, A., Bottero, S., Benfenati, E., Cevasco, A., Erratico, C., Maggioni, S., Massari, A., 

Pedemonte, F., Vigano, L. 2007. In vivo exposure of carp to graded concentrations of 

bisphenol A. Gen. Compar. Endoc. 153(1-3): 15-24. 
U.S. Environmental Protection Agency December 2010

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Maniero, M.G., Bila, D.M., Dezotti, M. 2008. Degradation and estrogenic activity removal of 

17β-estradiol and 17α-ethinylestradiol by ozonation and O3/H2O2. Sci. Total Env. 407(1): 105-

115. 

Mann, R.M., Hyne, R.V., Choung, C.B., Wilson, S.P. 2009. Amphibians and agricultural 

chemicals: Review of the risks in a complex environment. Env. Poll. 157(11): 2903-2927.

Marchesini, G.R., Meimaridou, A., Haasnoot, W., Meulenberg, E., Albertus, F., Mizuguchi, M., 

Takeuchi, M., Irth, H.s, Murk, A.J. 2008. Biosensor discovery of thyroxine transport 

disrupting chemicals. Tox. Appl. Pharm. 232(1): 150-160. 

Mariscal-Arcas, M., Rivas, A., Granada, A., Monteagudo, C., Murcia, M.A., Olea-Serrano, F. 

2009. Dietary exposure assessment of pregnant women to bisphenol-A from cans and 

microwave containers in Southern Spain. Food Chem. Tox. 47(2): 506-10. 

Markman, S., Guschina, I.A., Barnsley, S., Buchanan, K.L., Pascoe, D., Mueller, C.T. 2007. 

Endocrine disrupting chemicals accumulate in earthworms exposed to sewage effluent. 

Chemos. 70(1): 119-125. 

Markman, S., Leitner, S., Catchpole, C., Barnsley, S., Muller, C.T., Pascoe, D., Buchanan, K.L. 

2008. Pollutants increase song complexity and the volume of the brain area HVC in a songbird. 

School of Biosciences, Cardiff University, Cardiff, UK, PLoS ONE 3(2): e1674. 

Martinez-Guitarte, J.-L., Planello, R., Morcillo, G. 2009. Modulation of telomeric RNA 

expression by Bisphenol A and Cadmium in Chironomus riparius (Diptera). Comp. Biochem. 

Physiol. Part A Mol. Integr. Physiol. 154(1) Suppl. S: S18. 

Martinez-Guitarte, J.-L., Planello, R., Morcillo, G. 2008. Changes in the ecdysone response 

pathway after exposure to cadmium, pentachlorophenol and bisphenol - A in the aquatic larvae 

of Chironomus. Tox. Letters 180(Suppl. 1): S190-S191. 

Mazellier, P. , Méité, L., De Laat, J. 2008. Photodegradation of the steroid hormones 17βestradiol (E2) and 17α-ethinylestradiol (EE2) in dilute aqueous solution. Chemos. 73(8): 1216-

1223. 

McCormick, J. M., Cooper, K. R., White, L. A., Haggblom, M. H. 2008. Effects of 

Microbially Induced Transformations of Brominated Flame Retardants and Toxicity in 

Zebrafish. Abstracts of the General Meeting of the American Society for Microbiology, 

Boston, MA 108: 515. 

Meier, S., Andersen, T.E., Norberg, B., Thorsen, A., Taranger, G.L., Kjesbu, O.S., Dale, R., 

Morton, H.C., Klungsøyr, J., Svardal, A. 2007. Effects of alkylphenols on the reproductive 

system of Atlantic cod (Gadus morhua). Aqua. Tox. 81(2): 207-218. 

Meinert, C., Moeder, M., Brack, W. 2007. Fractionation of technical p-nonylphenol with 

preparative capillary gas chromatography. Chemos. 70(2): 215-223.
U.S. Environmental Protection Agency December 2010

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Miao, S., Gao, Z.-X., Xu, G.-F., Kou, Z.-Q., Su, C.-J. 2007. Effects of perinatal and lactational 

exposure to bisphenol a on the immune function of spleen in the offspring of rats. Asian J. 

Ecotox. 2(4): 416-421. 

Miguel-Queralt, S., Hammond, G.L. 2008. Sex hormone-binding globulin in fish gills is a 

portal for sex steroids breached by xenobiotics. Endoc. 149(9): 4269-4275. 

Mihaich, E.M., Friederich, U., Caspers, N., Hall, A.T., Klecka, G.M., Dimond, S.S., Staples, 

C.A., Ortego, L.S., Hentges, S.G. 2009. Acute and chronic toxicity testing of bisphenol A with 

aquatic invertebrates and plants. Ecotox. Env. Saf. 72(5): 1392-9. 

Mimoto, A., Fujii, M., Usami, M., Shimamura, M., Hirabayashi, N., Kaneko, T., Sasagawa, N., 

Ishiura, S. 2007. Identification of an estrogenic hormone receptor in Caenorhabditis elegans. 

Biochem. Biophys. Res. Commun. 364(4): 883-888. 

Minier, C., Forget-Leray, J., Bjornstad, A., Camus, L. 2008. Multixenobiotic resistance, 

acetyl-choline esterase activity and total oxyradical scavenging capacity of the Arctic spider 

crab, Hyas araneus, following exposure to bisphenol A, tetra bromo diphenyl ether and diallyl 

phthalate. Mar.Poll. Bull. 56(8): 1410-1415. 

Mitsui, N., Tooi, O., Kawahara, A. 2007. Vitellogenin-inducing activities of natural, synthetic, 

and environmental estrogens in primary cultured Xenopus laevis hepatocytes. Comp. Biochem. 

Physiol., Part C: Tox. Pharm. 146C(4): 581-587. 

Moens, L.N., Smolders, R., van der Ven, K., van Remortel, P., Del-Favero, J., De Coen, W.M. 

2007. Effluent impact assessment using microarray-based analysis in common carp: A systems 

toxicology approach. Chemos. 67(11): 2293-2304.

Moens, L.N., van der Ven, K., Van Remortel, R., Del-Favero, J., De Coen, W.M. 2007. Gene 

expression analysis of Estrogenic compounds in the liver of common carp (Cyprinus carpio) 

using a custom cDNA Microarray. J. Biochem.Mol. Tox. 21(5): 299-311. 

Mohapatra, D.P., Brar, S.K., Tyagi, R.D., Surampalli, R.Y. 2010. Physico-chemical pretreatment and biotransformation of wastewater and wastewater sludge--fate of bisphenol A. 

Chemos. 78(8): 923-41. 

Moon, H.-B., Choi, M., Choi, H.-G., Ok, G., Kannan, K. 2009. Historical trends of PCDDs, 

PCDFs, dioxin-like PCBs and nonylphenols in dated sediment cores from a semi-enclosed bay 

in Korea: Tracking the sources. Chemos. 75(5): 565-571. 

Morgado, I., Hamers, T., Van der Ven, L., Power, D.M. 2007. Disruption of thyroid hormone 

binding to sea bream recombinant transthyretin by ioxinyl and polybrominated diphenyl ethers. 

Chemos. 69(1): 155-163. 
U.S. Environmental Protection Agency December 2010

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Muncke, J., Junghans, M., Eggen, R.I.L. 2007. Testing estrogenicity of known and novel 

(xeno) estrogens in the MolDarT using developing zebrafish (Danio rerio). Env. Tox. 22(2): 

185-193. 

Myers, J.P., vom Saal, F.S., Akingbemi, B.T., Arizono, K., Belcher, S., Colborn, T., Chahoud, 

I., Crain, D.A., Farabollini, F., Guillette, L.J., Jr, Hassold, T., Ho, S.M., Hunt, P.A., Iguchi, T., 

Jobling, S., Kanno, J., Laufer, H., Marcus, M., McLachlan, J.A., Nadal, A., Oehlmann, J., Olea, 

N., Palanza, P., Parmigiani, S., Rubin, B.S., Schoenfelder, G., Sonnenschein, C., Soto, A.M., 

Talsness, C.E., Taylor, J.A., Vandenberg, L.N., Vandenbergh, J.G., Vogel, S., Watson, C.S., 

Welshons, W.V., Zoeller, R.T. 2009. Why public health agencies cannot depend on good 

laboratory practices as a criterion for selecting data: the case of bisphenol A. Env. Health 

Perspect. 117(3): 309-15. 

Nadzialek, S., Vanparys, C., Van der Heiden, E., Michaux, C., Brose, F., Scippo, M.-L., De 

Coen, W., Kestemont, P. 2010. Understanding the gap between the estrogenicity of an effluent 

and its real impact into the wild. Sci.Total Env. 408(4): 812-821.

Nagae, M., Suminami, Y., Kitagawa, H., Shiroyama, K., Ohkubo, N., Matsubara, T. 2008. 

Specific binding of exogenous sex hormones and chemical substances to sex hormone-binding 

globulin (SHBG) in carp and rainbow trout. Cybium 32(2) Suppl. S: 244. 

Nagarnaik, P.M., Mills, M.A., Boulanger, B. 2010. Concentrations and mass loadings of 

hormones, alkylphenols, and alkylphenol ethoxylates in healthcare facility wastewaters. 

Chemos. 78(8): 1056-1062.

Nakajima, N., Teramoto, T., Kasai, F., Sano, T., Tamaoki, M., Aono, M., Kubo, A., Kamada, 

H., Azumi, Y., Saji, H. 2007. Glycosylation of bisphenol A by freshwater microalgae. 

Chemos. 69(6): 934-941. 

Nakamura, H., Kuruto-Niwa, R., Uchida, M., Terao, Y. 2007. Formation of chlorinated 

estrones via hypochlorous disinfection of wastewater effluent containing estrone. Chemos. 

66(8): 1441-1448.

Neale, P.A., Escher, B.I., Schäfer, A.I. 2009. pH dependence of steroid hormone—organic 

matter interactions at environmental concentrations. Sci.Total Env. 407(3): 1164-1173.

Nelson, J., Bishay, F., van Roodselaar, A., Ikonomou, M., Law, F.C.P. 2007. The use of in 

vitro bioassays to quantify endocrine disrupting chemicals in municipal wastewater treatment 

plant effluents. Sci. Total Env. 374(1): 80-90. 

Nendza, M., Mueller, M. 2007. Discriminating toxicant classes by mode of action: 3. 

Substructure indicators. SAR and QSAR in Env. Res. 18(1-2): 155-168. 

Ning, B., Graham, N., Zhang, Y., Nakonechny, M., El-Din, M.G. 2007. Degradation of 

endocrine disrupting chemicals by ozone/AOPs. Oz. Sci. Eng. 29(3): 153-176. 
U.S. Environmental Protection Agency December 2010

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Ning, B., Graham, N.J.D., Zhang, Y. 2007. Degradation of octylphenol and nonylphenol by 

ozone – Part I: Direct reaction. Chemos. 68(6): 1163-1172.

Nomiyama, K., Tanizaki, T., Koga, T., Arizono, K., Shinohara, R. 2007. Oxidative 

degradation of BPA using TiO2 in water, and transition of estrogenic activity in the degradation 

pathways. Arch. Env. Contam. Tox. 52(1): 8-15. 

Notch, E.G., Miniutti, D.M., Mayer, G.D. 2007. 17α-Ethinylestradiol decreases expression of 

multiple hepatic nucleotide excision repair genes in zebrafish (Danio rerio). Aqua. Tox. 84(3): 

301-309. 

Nowack, B., Bucheli, T.D. 2007. Occurrence, behavior and effects of nanoparticles in the 

environment. Env. Poll. 150(1): 5-22.

Oehlmann, J., Oetken, M., Schulte-Oehlmann, U. 2008. A critical evaluation of the 

environmental risk assessment for plasticizers in the freshwater environment in Europe, with 

special emphasis on bisphenol A and endocrine disruption. Env. Res. 108(2): 140-149. 

Oehlmann, J., Schulte-Oehlmann, U., Kloas, W., Jagnytsch, O., Lutz, I., Kusk, K.O., 

Wollenberger, L., Santos, E.M., Paull, G.C., Van Look, K.J., Tyler, C.R. 2009. A critical 

analysis of the biological impacts of plasticizers on wildlife. Philos. Trans. R. Soc. Lond. B 

Biol. Sci. 364(1526): 2047-62. 

Oehlmann, J., Schulte-Oehlmann, U., Oetken, M., Bachmann, J., Lutz, I., Kloas, W. 2008. 

Superferminization as an effect of bisphenol A in Marisa cornuarietis. Ecotox. Env. Safety

69(3): 577-579. 

Oehlmann, J., Schulte-Oehlmann, U., Oetken, M., Bachmann, J., Lutz, I., Kloas, W. 2008. 

Superfeminization as an effect of bisphenol A in Marisa cornuarietis. Ecotox. Env. Saf.

69(3):577-9, author reply 580-1. 

Oh, S.M., Kim, H.R., Park, H.K., Choi, K., Ryu, J., Shin, H.S., Park, J.-S., Lee, J.S., Chung, K. 

H. 2009. Identification of estrogen-like effects and biologically active compounds in river 

water using bioassays and chemical analysis. Sci. Total Env. 407(21): 5787-5794. 

Ohta, S., Tokusawa, H., Nakao, T., Aozasa, O., Miyata, H., Alaee, M. 2008. Global 

contamination of coplanar polybrominated/chlorinated biphenyls (Co-PXBs) in the market 

fishes from Japan. Chemo. 73(1): Pages S31-S38.

Oka, T., Tooi, O., Mitsui, N., Miyahara, M., Ohnishi, Y., Takase, M., Kashiwagi, A., Shinkai, 

T., Santo, N., Iguchi, T. 2008. Effect of atrazine on metamorphosis and sexual differentiation 

in Xenopus laevis. Aqua. Tox. 87(4): 215-226. 

Oliveira-Filho, E.C., Grisolia, C.K., Paumgartten, F.J.R. 2009. Trans-generation study of the 

effects of nonylphenol ethoxylate on the reproduction of the snail Biomphalaria tenagophila. 

Ecotox. Env. Saf. 72(2): 458-465.
U.S. Environmental Protection Agency December 2010

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Oliver, R., May, E., Williams, J. 2007. Microcosm investigations of phthalate behaviour in 

sewage treatment biofilms. Sci. Total Env. 372(2-3): 605-614.

Olivero-Verbel, J., Padilla-Bottet, C., De la Rosa, O. 2008. Relationships between 

physicochemical parameters and the toxicity of leachates from a municipal solid waste landfill. 

Ecotox. Env. Saf. 70(2): 294-299.

Olmstead, A.W., Kosian, P.A., Korte, J.J., Holcombe, G.W., Woodis, K.K., Degitz, S.J. 2009. 

Sex reversal of the amphibian, Xenopus tropicalis, following larval exposure to an aromatase 

inhibitor. Aqua. Tox. 91(2): 143-150.

Olsvik, P.A., Lie, K.K., Sturve, J., Hasselberg, L., Andersen, O.K. 2009. Transcriptional 

effects of nonylphenol, bisphenol A and PBDE-47 in liver of juvenile Atlantic cod (Gadus 

morhua). Chemos. 75(3): 360-367. 

Oropesa, A.-L., García-Cambero, J.P., Soler, F. 2009. Glutathione and malondialdehyde levels 

in common carp after exposure to simazine. Env. Tox. Pharm. 27(1): 30-38.

Osterauer, R., Haus, N., Sures, B., Köhler, H.-R. 2009. Uptake of platinum by zebrafish 

(Danio rerio) and ramshorn snail (Marisa cornuarietis) and resulting effects on early 

embryogenesis. Chemos. 77(7) 975-982. 

Ozlem, C.A., Hatice, P. 2008. Effects of bisphenol A on the embryonic development of sea 

urchin (Paracentrotus lividus). Env. Tox. 23(3): 387-392. 

Pait, A.S., Nelson, J.O. A survey of indicators for reproductive endocrine disruption in 

Fundulus heteroclitus (killifish) at selected sites in the Chesapeake Bay. Mar. Env.Res. 68(4): 

170-177.

Palma, P., Palma, V.L., Matos, C., Fernandes, R.M., Bohn, A., Soares, A.M.V.M., Barbosa, 

I.R. 2009. Assessment of the pesticides atrazine, endosulfan sulphate and chlorpyrifos for 

juvenoid-related endocrine activity using Daphnia magna. Chemos. 76(3): 335-340.

Panzica, G.C., Mura, E., Miceli, D., Martini, M.A., Gotti, S., Viglietti-Panzica, C. 2009. 

Effects of xenoestrogens on the differentiation of behaviorally relevant neural circuits in higher 

vertebrates. Ann. N. Y. Acad. Sci. 1163: 271-8. 

Paris, M., Pettersson, K., Schubert, M., Bertrand, S., Pongratz, I., Escriva, H., Laudet, V. 2008. 

An amphioxus orthologue of the estrogen receptor that does not bind estradiol: Insights into 

estrogen receptor evolution. BMC Evol. Biol. 8: 219. 

Park, C.-B., Aoki, J., Lee, J.-S., Nagae, M., Lee, Y.-D., Sakakura, Y., Hagiwara, A., Soyano, K. 

2010. The effects of 17β-estradiol on various reproductive parameters in the hermaphrodite 

fish Kryptolebias marmoratus. Aqua. Tox. 96(4): 273-279. 
U.S. Environmental Protection Agency December 2010

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Park, K., Bang, H.W., Park, J., Kwak, I.-S. 2009. Ecotoxicological multilevel-evaluation of 

the effects of fenbendazole exposure to Chironomus riparius larvae. Chemos. 77(3): 359-367.

Park, K., Kwak, I.S. 2008. Characterization of heat shock protein 40 and 90 in Chironomus 

riparius larvae: Effects of di(2-ethylhexyl) phthalate exposure on gene expressions and 

mouthpart deformities. Chemos. 74(1): 89-95. 

Park, K., Kwak, I.-S. 2010. Molecular effects of endocrine-disrupting chemicals on the 

Chironomus riparius estrogen-related receptor gene. Chemos. 79(9): 934-941.

Park, K.J., Müller, C.T., Markman, S., Swinscow-Hall, O., Pascoe, D., Buchanan, K.L. 2009. 

Detection of endocrine disrupting chemicals in aerial invertebrates at sewage treatment works. 

Chemos. 77(11): 1459-1464.

Park, S.Y., Choi, J. 2007. Cytotoxicity, genotoxicity and ecotoxicity assay using human cell 

and environmental species for the screening of the risk from pollutant exposure. Env. Int. 33(6): 

817-822. 

Park, S.-Y., Choi, J. 2009. Genotoxic Effects of Nonylphenol and Bisphenol A Exposure in 

Aquatic Biomonitoring Species: Freshwater Crustacean, Daphnia magna, and Aquatic Midge, 

Chironomus riparius. Bull. Env. Contam. Tox. 83(4): 463-468. 

Passos, A.L.S., Pinto, P.I.S., Power, D.M., Canario, A.V.M. 2009. A yeast assay based on the 

gilthead sea bream (teleost fish) estrogen receptor β for monitoring estrogen mimics. Eco. Env. 

Saf. 72(5): 1529-1537. 

Paulos, P., Runnalls, T.J., Nallani, G., La Point, T., Scott, A.P., Sumpter, J.P., Huggett, D.B. 

2010. Reproductive Responses in Fathead Minnow and Japanese Medaka Following Exposure 

to a synthetic progestin, Norethindrone. Aqua. Tox. 99(2): 256-262.

Paumen, M.L., Borgman, E., Kraak, M.H.S., van Gestel, C.A.M., Admiraal, W. 2008. Life 

cycle responses of the midge Chironomus riparius to polycyclic aromatic compound exposure. 

Env. Poll. 152 (1): 225-232.

Pavlikova, N., Kortner, T.M., Arukwe, A. 2010. Peroxisome proliferator-activated receptors, 

estrogenic responses and biotransformation system in the liver of salmon exposed to tributyltin 

and second messenger activator. Aqua. Tox. 99(2): 176-185.

Peck, M.R., Labadie, P., Minier, C., Hill, E.M. 2007. Profiles of environmental and 

endogenous estrogens in the zebra mussel Dreissena polymorpha. Chemos. 69(1): 1-8. 

Peng, X., Wang, Z., Mai, B., Chen, F., Chen, S., Tan, J., Yu, Y., Tang, C., Li, K., Zhang, G., 

Yang, C. 2007. Temporal trends of nonylphenol and bisphenol A contamination in the Pearl 

River Estuary and the adjacent South China Sea recorded by dated sedimentary cores. Sci. Total 

Env. 384(1-3): 393-400. 
U.S. Environmental Protection Agency December 2010

29

Peng, X., Yu, Y., Tang, C., Tan, J., Huang, Q., Wang, Z. 2008. Occurrence of steroid 

estrogens, endocrine-disrupting phenols, and acid pharmaceutical residues in urban riverine 

water of the Pearl River Delta, South China. Sci. Total Env. 397(1-3): 158-166.

Perez-Bendito, M.D., Soledad, R.B., , Lunar-Reyes, M.L., Garcia-Prieto, A. 2009. 

Determination of bisphenol A in canned fatty foods by coacervative microextraction, liquid 

chromatography and fluorimetry. Food Additives Contam. 26(2): 265-274. 

Pettersson, M., Hahlbeck, E., Katsiadaki, L., Asplund, L., Bengtsson, B.-E. 2007. Survey of 

estrogenic and androgenic disruption in Swedish coastal waters by the analysis of bile fluid 

from perch and biomarkers in the three-spined stickleback. Mar. Poll. Bull. 54(12): 1868-1880. 

Planelló, R., J.L. Martínez-Guitarte, J.L., G. Morcillo, G. 2010. Effect of acute exposure to 

cadmium on the expression of heat-shock and hormone-nuclear receptor genes in the aquatic 

midge Chironomus riparius. Sci. Total Env. 408(7): 1598-1603.

Planelló, R., Martinez, J.L., Morcillo, G. 2008. Effect of bisphenol-A in the expression of 

housekeeping, stress-induced and hormone-related genes in the aquatic larvae of the midge 

Chironomus. Toxic. Letters 180(Suppl. 1): S197. 

Planelló, R., Martinez-Guitarte, J. L., Morcillo, G. 2008. The endocrine disruptor bisphenol A 

increases the expression of HSP70 and ecdysone receptor genes in the aquatic larvae of 

Chironomus riparius. Chemos. 71(10) 1870-1876. 

Plósz, B.G., Leknes, H., Liltved, H., Thomas, K.V. 2010. Diurnal variations in the occurrence 

and the fate of hormones and antibiotics in activated sludge wastewater treatment in Oslo, 

Norway. Sci. Total Env. 408(8): 1915-1924.

Podlipna, D., Cichna-Markl, M. 2007. Determination of bisphenol A in canned fish by sol-gel 

immunoaffinity chromatography, HPLC and fluorescence detection. Eur. Food Res. Tech.

224(5): 629-634. 

Pojana, G., Gomiero, A., Jonkers, N., Marcomini, A. 2007. Natural and synthetic endocrine 

disrupting compounds (EDCs) in water, sediment and biota of a coastal lagoon. Env. Int. 33(7): 

929-936. 

Press-Kristensen, K., Ledin, A., Schmidt, J.E., Henze, M. 2007. Identifying model pollutants 

to investigate biodegradation of hazardous XOCs in WWTPs. Sci. Total Env. 373(1): 122-130.

Qin, Z.-F., Qin, X.-F., Yang, L., Li, H.-T., Zhao, X.-R., Xu, X.-B. 2007. Feminizing/ 

demasculinizing effects of polychlorinated biphenyls on the secondary sexual development of 

Xenopus laevis. Aqua. Tox. 84(3): 321-327. 

Quednow, K., Püttmann, W. 2008. Endocrine disruptors in freshwater streams of Hesse, 

Germany: changes in concentration levels in the time span from 2003 to 2005. Env. Poll. 

152(2):476-83. 
U.S. Environmental Protection Agency December 2010

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Quick, E.L., Parry, E.M., Parry, J.M. 2008. Do oestrogens induce chromosome specific 

aneuploidy in vitro, similar to the pattern of aneuploidy seen in breast cancer? Mutat. Res.

651(1-2):46-55. 

Quinn, B., Gagné, F., Blaise, C. 2008. An investigation into the acute and chronic toxicity of 

eleven pharmaceuticals (and their solvents) found in wastewater effluent on the cnidarian, 

Hydra attenuata. Sci. Total Env. 389(2-3): 306-314. 

Quinn, B., Gagné, F., Blaise, C. 2008. The effects of pharmaceuticals on the regeneration of 

the cnidarian, Hydra attenuata. Sci. Total Env. 402(1): 62-69. 

Quinn, B., Gagné, F., Blaise, C. 2009. Evaluation of the acute, chronic and teratogenic effects 

of a mixture of eleven pharmaceuticals on the cnidarian, Hydra attenuata. Sci. Total Env. 

407(3): 1072-1079.

Raisuddin, S., Kwok, K.W.H., Leung, K.M.Y., Schlenk, D., Lee, J.S. 2007. The copepod 

Tigriopus: A promising marine model organism for ecotoxicology and environmental 

genomics. Aqua. Tox. 83(3): 161-173.

Ralph Urbatzka, R., Anne van Cauwenberge, A., Silvia Maggioni, S., Luigi Viganò, L., Alberta 

Mandich, A., Emilio Benfenati, E., Ilka Lutz, I., Werner Kloas, W. 2007. Androgenic and 

antiandrogenic activities in water and sediment samples from the river Lambro, Italy, detected 

by yeast androgen screen and chemical analyses. Chemos. 67 (6): 1080-1087. 

Ramakrishnan, S., Wayne, N.L. 2008. Impact of bisphenol A on early embryonic development 

and reproductive maturation. Repro. Tox. 25(2): 177-183. 

Reinstorf, F., Strauch, G., Schirmer, K., Gläser, H.-R., Möder, M., Wennrich, R., Osenbrück, 

K., Schirmer, M. 2008. Mass fluxes and spatial trends of xenobiotics in the waters of the city 

of Halle, Germany. Env. Poll. 152(2): 452-460.

Rhee, J.-S., Kang, H.S., Raisuddin, S., Hwang, D.-S., Han, J, Kim, R.-O., Seo, J.S., Lee, Y.-M., 

Park, G.S., Lee, S.-J., Lee, J.-S. 2009. Endocrine disruptors modulate expression of hepatic 

choriogenin genes in the hermaphroditic fish, Kryptolebias marmoratus. Compar. Biochem. 

Physiol. Part C Tox. Pharm. 150(2): 170-178. 

Rhee, J.-S., Lee, Y.-M., Raisuddin, S., Lee, J.-S. 2009. Expression of R-ras oncogenes in the 

hermaphroditic fish Kryptolebias marmoratus, exposed to endocrine disrupting chemicals. 

Compar. Biochem. Physiol. Part C: Tox. Pharm. 149C(3):433-439. 

Rhee, J.-S., Raisuddin, S., Hwang, D.-S., Lee, K.-W., Kim, I.-C., Lee, J.-S. 2009. Differential 

expression of metallothionein (MT) gene by trace metals and endocrine-disrupting chemicals in 

the hermaphroditic mangrove killifish, Kryptolebias marmoratus. Ecotox. Env. Saf. 72(1): 206-

212. 
U.S. Environmental Protection Agency December 2010

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Rhee, J.-S., Raisuddin, S., Lee, K.-W., Seo, J.S., Ki, J.-S., Kim, I.-C., Park, H.G., Lee, J.-S. 

2009. Heat shock protein (Hsp) gene responses of the intertidal copepod Tigriopus japonicus to 

environmental toxicants. Compar. Biochem. Physiol. Part C Tox. Pharm. 149(1): 104-112. 

Rhee, J.-S., Seo, J.S., Raisuddin, S., Ki, J.-S., Lee, K.-W., Kim, I.-C., Yoon, Y.-D., Lee, J.-S. 

2008. Gonadotropin-releasing hormone receptor (GnRHR) gene expression is differently 

modulated in gender types of the hermaphroditic fish Kryptolebias marmoratus by endocrine 

disrupting chemicals. Comp. Biochem. Physiol. Part C: Tox. Pharm. 147C(3): 357-365. 

Ribeiro, C., Pardal, M.A., Martinho, F., Margalho, R., Tiritan, M.E., Rocha, E., Rocha, M.J. 

2009. Distribution of endocrine disruptors in the Mondego River estuary, Portugal. Env. 

Monitor. Assess. 149(1-4): 183-193. 

Ribeiro, C., Tiritan, M.E., Rocha, E., Rocha, M.J. 2009. Seasonal and Spatial Distribution of 

Several Endocrine-Disrupting Compounds in the Douro River Estuary, Portugal. Arch. Env. 

Contam. Tox. 56(1): 1-11. 

Robinson, B.J., Hellou, J. 2009. Biodegradation of endocrine disrupting compounds in harbour 

seawater and sediments. Sci. Total Env. 407(21): 5713-5718.

Roh, H., Subramanya, N., Zhao, F., Yu, C.P., Sandt, J., Chu, K.H. 2009. Biodegradation 

potential of wastewater micropollutants by ammonia-oxidizing bacteria. Chemos. 77(8): 1084-

1089. 

Roh, J.Y., Choi, J. 2008. Ecotoxicological evaluation of chlorpyrifos exposure on the 

nematode Caenorhabditis elegans. Ecotox. Env. Saf. 71(2): 483-489.

Roh, J.Y., Park, Y.-K., Park, K., Choi, J. 2010. Ecotoxicological investigation of CeO2 and 

TiO2 nanoparticles on the soil nematode Caenorhabditis elegans using gene expression, growth, 

fertility, and survival as endpoints. Env. Tox. Pharm. 29(2): 167-172. 

Roncaglioni, A., Piclin, N., Pintore, M., Benfenati, E. 2008. Binary classification models for 

endocrine disrupter effects mediated through the estrogen receptor. SAR and QSAR in Env. 

Res. 19(7-8): 697-733. 

Rouleau, C., Kohli, J. 2008. Distribution of 14C-labelled atrazine, methoxychlor, glyphosate, 

and bisphenol-A in goldfish studied by whole-body autoradiography (WBARG) Water Qual. 

Res. J. Canada 43(4): 265-274. 

Rüdel, H., Müller, J., Steinhanses, J., Schröter-Kermani, C. 2007. Retrospective monitoring of 

organotin compounds in freshwater fish from 1988 to 2003: Results from the German 

environmental specimen bank. Chemos. 66(10): 1884-1894. 

Ryan, B.C., Hotchkiss, A.K., Crofton, K.M., Gray, L.E. Jr. 2010. In Utero and Lactational 

Exposure to Bisphenol A, In Contrast to Ethinyl Estradiol, Does Not Alter Sexually Dimorphic 

Behavior, Puberty, Fertility, and Anatomy of Female LE Rats. Tox. Sci. 114(1): 133-148. 
U.S. Environmental Protection Agency December 2010

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Rybakovas, A., Baršienė, J., Lang, T. 2009. Environmental genotoxicity and cytotoxicity in 

the offshore zones of the Baltic and the North Seas. Mar. Env. Res. 68(5): 246-256.

Sakamoto, H., Shoji, S., Kaneko, H. 2007. Leaching characteristics of bisphenol A from 

epoxy-resin pavement materials. Tox. Env. Chem. 89(1-4): 191-203. 

Salinas, Kim, A., Hemmer, M.J., Harris, P.S., Walker, C.C. 2008. A simple and rapid matrixassisted laser desorption/ionization time of flight mass spectrometry method to screen fish 

plasma samples for estrogen-responsive biomarkers. Env. Tox. Chem. 27(5): 1175-1183. 

Sánchez-Argüello, P., Fernández, C., Tarazona, J.V. 2009. Assessing the effects of fluoxetine 

on Physa acuta (Gastropoda, Pulmonata) and Chironomus riparius (Insecta, Diptera) using a 

two-species water–sediment test. Sci. Total Env. 407(6): 1937-1946. 

Sánchez-Avila, J., Bonet, J., Velasco, G., Lacorte, S. 2009. Determination and occurrence of 

phthalates, alkylphenols, bisphenol A, PBDEs, PCBs and PAHs in an industrial sewage grid 

discharging to a Municipal Wastewater Treatment Plant. Sci. Total Env. 407(13): 4157-4167. 

Sánchez-Avila, J., Quintana, J., Ventura, F., Tauler, R., Duarte, C.M., Lacorte, S. 2010. Stir 

bar sorptive extraction-thermal desorption-gas chromatography–mass spectrometry: An 

effective tool for determining persistent organic pollutants and nonylphenol in coastal waters in 

compliance with existing Directives. Mar. Poll. Bull. 60(1): 103-112. 

Sarmah, A.K., Northcott, G.L. 2008. Laboratory degradation studies of four endocrine 

disruptors in two environmental media. Environ. Toxicol. Chem. 27(4):819-27. 

 

Sawasdee, B., Köhler, H.-R. 2009. Embryo toxicity of pesticides and heavy metals to the 

ramshorn snail, Marisa cornuarietis (Prosobranchia). Chemos. 75(11): 1539-1547.

Schaefer, S., Bickmeyer, U., Koehler, A. 2009. Measuring Ca2+-signalling at fertilization in 

the sea urchin Psammechinus miliaris: Alterations of this Ca2+-signal by copper and 2,4,6-

tribromophenol. Compar. Biochem. Physiol. Part C Tox. Pharm. 150(2): 261-269. 

Schilirò, T., Pignata, C., Rovere, R., Fea, E., Gilli, G. 2009. The endocrine disrupting activity 

of surface waters and of wastewater treatment plant effluents in relation to chlorination. 

Chemos. 75(3): 335-340. 

Schlenk, D. 2008. Are steroids really the cause for fish feminization? A mini-review of in 

vitro and in vivo guided TIEs. Mar. Poll. Bull. 57(6-12): 250-254. 

Schmitt, C., Balaam, J., Leonards, P., Brix, R., Streck, G., Tuikka, A., Bervoets, L., Brack, W., 

van Hattum, B., Meire, P., de Deckere, E. 2010. Characterizing field sediments from three 

European river basins with special emphasis on endocrine effects – A recommendation for 

Potamopyrgus antipodarum as test organism. Chemos. 80(1): 13-19. 
U.S. Environmental Protection Agency December 2010

33

Schmitt, C., Oetken, M., Dittberner, O., Wagner, M., Oehlmann, J. 2008. Endocrine 

modulation and toxic effects of two commonly used UV screens on the aquatic invertebrates 

Potamopyrgus antipodarum and Lumbriculus variegatus. Env. Poll. 152(2): 322-329. 

Schoenfuss, H.L., Bartell, S.E., Bistodeau, T.B., Cediel, R.A., Grove, K.J., Zintek, L., Lee, 

K.E., Barber, L.B. 2008. Impairment of the reproductive potential of male fathead minnows by 

environmentally relevant exposures to 4-nonylphenolf. Aqua. Tox. 86(1): 91-98. 

Schramm, K.-W., Jaser, W., Welzl, G., Pfister, G., Wöhler-Moorhoff, G.F., Hense, B.A. 2008. 

Impact of 17α-ethinylestradiol on the plankton in freshwater microcosms—I: Response of 

zooplankton and abiotic variables. Ecotox. Env. Saf. 69(3): 437-452. 

Schubert, S., Peter, A., Burki, R., Schönenberger, R., Suter, M.J.-F., Segner, H., BurkhardtHolm, P. 2008. Sensitivity of brown trout reproduction to long-term estrogenic exposure. 

Aqua. Tox. 90(1): 65-72. 

Serafimova, R., Todorov, M., Pavlov, T., Kotov, S., Jacob, E., Aptula, A., Mekenyan, O. 2007. 

Identification of the Structural Requirements for Mutagenicity, by Incorporating Molecular 

Flexibility and Metabolic Activation of Chemicals. II. General Ames Mutagenicity Model. 

[Erratum to document cited below] Chem. Res. in Tox. 20(8): 1225. 

Serafimova, R., Todorov, M., Pavlov, T., Kotov, S., Jacob, E., Aptula, A., Mekenyan, O. 2007. 

Identification of the Structural Requirements for Mutagenicity, by Incorporating Molecular 

Flexibility and Metabolic Activation of Chemicals. II. General Ames Mutagenicity Model. 

Chem. Res. in Tox. 20(4): 662-676. 

Shareef, A., Egerer, S., Kookana, R. 2009. Effect of triclosan and triclocarban biocides on 

biodegradation of estrogens in soils. Chemos. 77(10): 1381-1386.

Sharma, B., Patiño, R. 2009. Effects of cadmium on growth, metamorphosis and gonadal sex 

differentiation in tadpoles of the African clawed frog, Xenopus laevis. Chemos. 76(8): 1048-

1055. 

Sharma, V.K., Anquandah, G.A., Yngard, R.A., Kim, H., Fekete, J., Bouzek, K., Ray, A.K., 

Golovko, D. 2009. Nonylphenol, octylphenol, and bisphenol-A in the aquatic environment: a 

review on occurrence, fate, and treatment. J. Env. Sci. Health A Tox. Hazard Subst. Env. Eng. 

44(5): 423-42. 

Sheikh, M.A., Fujimura, H., Miyagi, T., Uechi, Y., Yokota, T., Yasumura, S., Oomori, T. 

2009. Detection and ecological threats of PSII herbicide diuron on coral reefs around the 

Ryukyu Archipelago, Japan. Mar. Poll. Bull. 58(12): 1922-1926. 

Singh, P.B., Singh, V. 2008. Cypermethrin induced histological changes in gonadotrophic 

cells, liver, gonads, plasma levels of estradiol-17β and 11-ketotestosterone, and sperm motility 

in Heteropneustes fossilis (Bloch). Chemos. 72(3): 422-431. 
U.S. Environmental Protection Agency December 2010

34

Smital, T. 2008. Acute and Chronic Effects of Emerging Contaminants. Handbook of 

Environmental Chemistry, Berlin, Germany, 105-142. 

Sowers, A.D., Gaworecki, K.M., Mills, M.A., Roberts, A.P., Klaine, S.J. 2009. Developmental 

effects of a municipal wastewater effluent on two generations of the fathead minnow, 

Pimephales promelas. Aqua. Tox. 95(3): 173-181. 

Sowers, A.D., Mills, M.A., Klaine, S.J. 2009. The developmental effects of a municipal 

wastewater effluent on the northern leopard frog, Rana pipiens. Aqua. Tox. 94(2): 145-152. 

Staples, C., Friederich, U., Hall, T., Klecka, G., Mihaich, E., Ortego, L., Caspers, N., Hentges, 

S. 2010. Estimating potential risks to terrestrial invertebrates and plants exposed to bisphenol 

A in soil amended with activated sludge biosolids. Env. Tox. Chem. 29(2): 467-475. 

Stoichev, T., Baptista, M.S., Basto, M.C.P., Carvalho, P.N., Vasconcelos, M.T.S.D. 2008. 

Application of SPME to the determination of alkylphenols and bisphenol A in cyanobacteria 

culture media. Anal. Bioanal. Chem. 391(1): 425-432. 

Strömqvist, M., Tooke, N., Brunström, B. 2010. DNA methylation levels in the 5′ flanking 

region of the vitellogenin I gene in liver and brain of adult zebrafish (Danio rerio)—Sex and 

tissue differences and effects of 17α-ethinylestradiol exposure. Aqua. Tox. 98(3): 275-281. 

Stumpe, B., Marschner, B. 2007. Long-term sewage sludge application and wastewater 

irrigation on the mineralization and sorption of 17β-estradiol and testosterone in soils. Sci.Total 

Env. 374(2-3): 282-291. 

Sugiyama, D., Okano, D., Fukushima, M., Ohmori, S., Niinuma, K., Yoshida, W., Ishida, S. 

2008. Effects of bisphenol A on the freshwater planarians. Hirosaki Daigaku Nogaku Seimei 

Kagakubu Gakujutsu Hokoku 11: 1-19. 

Sui, Q., Huang, J., Yu, G. 2009. Priority analysis for controlling endocrine disrupting 

chemicals in municipal wastewater treatment plants of China. Huan Jing Ke Xue 30(2): 384-90. 

Sullivan, C., Mitchelmore, C.L., Hale, R.C., Van Veld, P.A. 2007. Induction of CYP1A and 

DNA damage in the fathead minnow (Pimephales promelas) following exposure to biosolids. 

Sci. Total Env. 384(1-3): 221-228. 

Sumi, M., Kawashima, Y., Fukumaki, T., Ishibashi, H., Arizono, K., Iguchi, T., Shimizu, M. 

2007. Comparison of serum vitellogenin, steroid hormone, gonad histopathology and 

bioaccumulation in common carp (Cyprinus carpio) of two rivers and a lake in Japan: Potential 

for endocrine disruption. Env. Sci. 14(1): 41-54. 

Sun, H., Xu, X.L., Qu, J.H., Hong, X., Wang, Y.B., Xu, L.C., Wang, X.R. 2008. 4-

Alkylphenols and related chemicals show similar effect on the function of human and rat 

estrogen receptor α in reporter gene assay. Chemos. 71(3): 582-588. 
U.S. Environmental Protection Agency December 2010

35

Sun, L., Zha, J., Spear, P.A., Wang, Z. 2007. Tamoxifen effects on the early life stages and 

reproduction of Japanese medaka (Oryzias latipes). Env. Tox. Pharm. 24(1): 23-29. 

Sun, L., Zha, J., Wang, Z. 2009. Interactions between estrogenic chemicals in binary mixtures 

investigated using vitellogenin induction and factorial analysis. Chemos. 75(3): 410-415. 

Sun, Q., Deng, S., Huang, J., Shen, G., Yu, G. 2009. Contributors to estrogenic activity in 

wastewater from a large wastewater treatment plant in Beijing, China. Env. Tox. Pharm. (25): 

20-26. 

Sun, W.L., Ni, J.R., Xu, N., Sun, L.Y. 2007. Fluorescence of sediment humic substance and its 

effect on the sorption of selected endocrine disruptors. Chemos. 66(4):700-7. 

Sun, Y., Guo, H., Yu, H., Wang, X., Wu, J., Xue, Y. 2008. Bioaccumulation and physiological 

effects of tetrabromobisphenol A in coontail Ceratophyllum demersum L. Chemos. 70(10): 

1787-1795. 

Sung, H.H., Ye, Y.-Z. 2009. Effect of nonylphenol on giant freshwater prawn 

(Macrobrachium rosenbergii) via oral treatment: Toxicity and messenger RNA expression of 

hemocyte genes. Aqua. Tox. 91(3): 270-277. 

Taban, I. C., Bechmann, R.K., Torgrimsen, S., Sundt, R., Bjornstad, A., Larsen, B.K., 

Andersen, O.K. 2008. DNA damage in mussels following exposure to three potential 

endocrine disruptors using the comet assay and the a alkaline unwinding assay. Mar.Env. Res.

66(1): 65. 

Takao, Y., Oishi, M., Nagae, M., Kohra, S., Arizono, K. 2008. Bisphenol a incorporated into 

eggs from parent fish persists for several days. J. Health Sci. 54(2): 235-239. 

Takeda, Y., Liu, X., Maisushima, A., Shimohigashi, M., Shimohigashi, Y. 2007. Distribution 

of estrogen-related receptors (ERR), human ERR gamma and Drosophila ERR, as bisphenol A 

receptors. Compar. Biochem. Physiol Part B Biochem. Mol. Biol. 148(3): 353. 

Tan, F., Zhao, H., Li, X., Quan, X., Chen, J., Xiang, X., Zhang, X. 2009. Preparation and 

evaluation of molecularly imprinted solid-phase microextraction fibers for selective extraction 

of bisphenol A in complex samples. J. Chromat. A. 1216(30): 5647-54. 

Tanaka, T., Tamura, T., Ishizaki, Y., Kawasaki, A., Kawase, T., Teraguchi, M., Taniguchi, M. 

2009. Enzymatic treatment of estrogens and estrogen glucuronide. J. Env. Sci. 21(6): 731-735.

Taowu Ma, Shuangjiao Gong, Ke Zhou, Cheng Zhu, Kaidong Deng, Qinghua Luo, Zijian 

Wang. 2010. Laboratory culture of the freshwater benthic gastropod Bellamya aeruginosa

(Reeve) and its utility as a test species for sediment toxicity. J. Env. Sci. 22(2): 304-313. 

Tarja Nakari, T., Sami Huhtala, S. 2008. Comparison of toxicity of congener-153 of PCB, 

PBB, and PBDE to Daphnia magna. Ecotox. Env. Saf. 71(2): 514-518. 
U.S. Environmental Protection Agency December 2010

36

Tatarazako, N., Oda, S. 2007. The water flea Daphnia magna (Crustacea, Cladocera) as a test 

species for screening and evaluation of chemicals with endocrine disrupting effects on 

crustaceans. Eco. 16(1): 197-203. 

Tayama, S., Nakagawa, Y., Tayama, K. 2008. Genotoxic effects of environmental estrogenlike compounds in CHO-K1 cells. Mut. Res. Gen. Tox. Env. Muta. 649(1-2): 114-125. 

Terasaki, M., Shiraishi, F., Fukazawa, H.-I., Makino, M. 2007. Occurrence and estrogenicity 

of phenolics in paper-recycling process water: Pollutants originating from thermal paper in 

waste paper. Env. Tox. Chem. 26(11): 2356-2366. 

Teuten, E.L., Saquing, J.M., Knappe, D.R., Barlaz, M.A., Jonsson, S., Björn, A., Rowland, S.J., 

Thompson, R.C., Galloway, T.S., Yamashita, R., Ochi, D., Watanuki, Y., Moore, C., Viet, P.H., 

Tana, T.S., Prudente, M., Boonyatumanond, R., Zakaria, M.P., Akkhavong, K., Ogata, Y., 

Hirai, H., Iwasa, S., Mizukawa, K., Hagino, Y., Imamura, A., Saha, M., Takada, H. 2009. 

Transport and release of chemicals from plastics to the environment and to wildlife. Philos. 

Trans. R. Soc. Lond. B Biol. Sci. 364(1526): 2027-45. 

Thomas, P., Sweatman, J. 2008. Interference by Atrazine and Bisphenol-A with Progestin 

Binding to the Ovarian Progestin Membrane Receptor and Induction of Oocyte Maturation in 

Atlantic Croaker. Mar. Env. Res. 66(1):1-2. 

Tian, H., Ru, S., Bing, X., Wang, W. 2010. Effects of monocrotophos on the reproductive axis 

in the male goldfish (Carassius auratus): Potential mechanisms underlying vitellogenin 

induction. Aqua. Tox. 98(1): 67-73. 

Tillitt, D.E., Papoulias, D.M., Whyte, J.J., Richter, C.A. 2010. Atrazine reduces reproduction 

in fathead minnow (Pimephales promelas). Aqua. Tox. 99(2): 149-159.

Tölgyesi, Á., Verebey, Z., Sharma, V.K., Kovacsics, L., Fekete, J. 2010. Simultaneous 

determination of corticosteroids, androgens, and progesterone in river water by liquid 

chromatography–tandem mass spectrometry. Chemos. 78(8): 972-979.

Tollefsen, K.-E. 2007. Binding of alkylphenols and alkylated non-phenolics to the rainbow 

trout (Oncorhynchus mykiss) plasma sex steroid-binding protein. Ecotox. Env. Saf. 68(1): 40-

48.

Tollefsen, K.-E., Eikvar, S., Farmen Finne, E., Fogelberg, O., Gregersen, I. K. 2008. 

Estrogenicity of alkylphenols and alkylated non-phenolics in a rainbow trout (Oncorhynchus 

mykiss) primary hepatocyte culture. Ecotox. Env. Saf. 71(2): 370-383. 

Tollefsen, K.-E., Harma, C., Smith, A., Thomas, K.V. 2007. Estrogen receptor (ER) agonists 

and androgen receptor (AR) antagonists in effluents from Norwegian North Sea oil production 

platforms. Mar. Poll. Bull. 54(3): 277-283. 
U.S. Environmental Protection Agency December 2010

37

Toyoizumi, T., Deguch, Y., Masuda, S., Kinae, N. 2008. Genotoxicity and estrogenic activity 

of 3,3 '-dinitrobisphenol A in goldfish. Biosci. Biotech. Biochem. 72(8): 2118-2123. 

Vajda, A.M., Barber, L.B., Gray, J.L., Lopez, E.M., Woodling, J.D., Norris, D.O. 2008. 

Reproductive disruption in fish downstream from an Estrogenic wastewater effluent. Env. Sci. 

Tech. 42(9): 3407-3414. 

Van den Steen, E., Covaci, A., Jaspers, V.L.B., Dauwe, T., Voorspoels, S., Eens, M., Pinxten, 

R. 2007. Accumulation, tissue-specific distribution and debromination of decabromodiphenyl 

ether (BDE 209) in European starlings (Sturnus vulgaris). Env. Poll. 148(2): 648-653.

Vedani, A., Spreafico, M., Peristera, O., Dobler, M., Smiesko, M. 2008. VirtualToxLab - in 

silico prediction of the endocrine-disrupting potential of drugs and chemicals. Chimia 62(5): 

322-328. 

Veldhoen, N., Lowe, C.J., Davis, C., Mazumder, A., Helbing, C.C. 2009. Gene expression 

profiling in the deep water horse mussel Modiolus modiolus (L.) located near a marine 

municipal wastewater outfall. Aqua. Tox. 93(2-3): 116-124.

Verliefde, A., Cornelissen, E., Amy, G., Van der Bruggen, B., van Dijk, H. 2007. Priority 

organic micropollutants in water sources in Flanders and the Netherlands and assessment of 

removal possibilities with nanofiltration. Env. Poll. 146(1): 281-289.

Viganò, L., Benfenati, E., van Cauwenberge, A., Eidem, J.K., Erratico, C., Goksøyr, A., Kloas, 

W., Maggioni, S., Mandich, A., Urbatzka, R. 2008. Estrogenicity profile and estrogenic 

compounds determined in river sediments by chemical analysis, ELISA and yeast assays. 

Chemos. 73(7): 1078-1089.

Vinggaard, A.M., Niemelae, J., Bay Wedebye, E., Jensen, G.E. 2008. Screening of 397 

Chemicals and Development of a Quantitative Structure-Activity Relationship Model for 

Androgen Receptor Antagonism. Chem. Res. Tox. 21(4): 813-823. 

Walker, C.C., Salinas, K.A., Harris, P.S., Wilkinson, S.S., Watts, J.D., Hemmer, M.J. 2007. A 

Proteomic (SELDI-TOF-MS) Approach to Estrogen Agonist Screening. Tox. Sci. 95(1): 74-81. 

Walker, D.B., Paretti, N.V., Cordy, G., Gross, T.S., Zaugg, S.D., Furlong, E.T., Kolpin, D.W., 

Matter, W.J., Gwinn, J., McIntosh, D. 2009. Changes in reproductive biomarkers in an 

endangered fish species (bonytail chub, Gila elegans) exposed to low levels of organic 

wastewater compounds in a controlled experiment. Aqua. Tox. 95(2): 133-143. 

Wang, L.-Q., James, M.O. 2007. Sulfonation of 17β-estradiol and inhibition of 

sulfotransferase activity by polychlorobiphenylols and celecoxib in channel catfish, Ictalurus 

punctatus. Aqua. Tox. 81(3): 286-292. 
U.S. Environmental Protection Agency December 2010

38

Wang, Y., Ed., Li, S.C., Ed., Huang, P., Ed., Yang, Y.H., Ed., An, Y., Ed., Sun, X.Y., Ed. 

2007. Progress in Environmental Science and Technology, Vol I. Science Press Beijing, 

Beijing, People’s Republic of China. 

Warner, K.E., Jenkins, J.J. 2007. Effects of 17α-ethinylestradiol and bisphenol A on vertebral 

development in the fathead minnow (Pimephales promelas). Env. Tox. Chem. 26(4): 732-737. 

Wauhob, T.J., Nipper, M., Billiot, E. 2007. Seasonal variation in the toxicity of sedimentassociated contaminants in Corpus Christi Bay, TX. Mar. Poll. Bull. 54(8): 1116-1126.

Wetherill, Y.B., Akingbemi, B.T., Kanno, J., McLachlan, J.A., Nadal, A., Sonnenschein, C., 

Watson, C.S., Zoeller, R.T., Belcher, S.M. 2007. In vitro molecular mechanisms of bisphenol 

A action. Repro. Tox. 24(2):178-98. 

Wu, Y., Zhou, Q., Li, H., Liu, W., Wang, T., Jiang, G. 2009. Effects of silver nanoparticles on 

the development and histopathology biomarkers of Japanese medaka (Oryzias latipes) using the 

partial-life test. Aqua. Tox. 100(2): 160-167.

Xiao, J., Shao, B., Wu, Y.-N., Wang, Z.-T., Hou, W. 2007. Determination of bisphenol A and 

alkyl phenols in canned food with high performance liquid chromatography-fluorescence. 

Zhonghua Yufang Yixue Zazhi 41(6): 449-452. 

Xu J, Wu L, Chang AC. 2009. Degradation and adsorption of selected pharmaceuticals and 

personal care products (PPCPs) in agricultural soils. Chemos. 77(10): 1299-305. 

Yamauchi, R., Ishibashi, H., Hirano, M., Mori, T., Kim, J.-W., Arizono, K. 2008. Effects of 

synthetic polycyclic musks on estrogen receptor, vitellogenin, pregnane X receptor, and 

cytochrome P450 3A gene expression in the livers of male medaka (Oryzias latipes). Aqua. 

Tox. 90(4): 261-268.

Yan, H., Takamoto, M., Sugane, K. 2008. Exposure to bisphenol a prenatally or in adulthood 

promotes T(H)2 cytokine production associated with reduction of CD4(+)CD25(+) regulatory T 

cells. Env. Health Persp. 116(4): 514-519. 

Yan, W., Li, Y., Zhao, L., Lin, J.M. 2009. Determination of estrogens and bisphenol A in 

bovine milk by automated on-line C30 solid-phase extraction coupled with high-performance 

liquid chromatography-mass spectrometry. J. Chromat. A 1216(44): 7539-45. 

Yang, G., Kille, P., Ford, A.T. 2008. Infertility in a marine crustacean: Have we been ignoring 

pollution impacts on male invertebrates? Aqua. Tox. 88(1): 81-87. 

Yang, Y., Liu, Z., Zheng, M., Zhao, Y., Wang, L., Sun, W., Xiao, F. 2008. The acute lethality 

and endocrine effect of 1,2,3,7,8-PeCDD in juvenile goldfish (Carassius auratus) in vivo. J. 

Env. Sci. 20(2): 240-245. 
U.S. Environmental Protection Agency December 2010

39

Ye, X., Pierik, F.H., Angerer, J., Meltzer, H.M., Jaddoe, V.W., Tiemeier, H., Hoppin, J.A., 

Longnecker, M.P. 2009. Levels of metabolites of organophosphate pesticides, phthalates, 

andbisphenol A in pooled urine specimens from pregnant women participating in the 

Norwegian Mother and Child Cohort Study (MoBa). Int. J. Hyg. Env. Health 212(5): 481-91. 

 

Ye, X., Pierik, F.H., Hauser, R., Duty, S., Angerer, J., Park, M.M., Burdorf, A., Hofman, A., 

Jaddoe, V.W., Mackenbach, J.P., Steegers, E.A., Tiemeier, H., Longnecker, M.P. 2008. 

Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and 

phthalates among pregnant women in Rotterdam, the Netherlands: the Generation R study. Env. 

Res. 108(2):260-7. 

Yin, D.-Q., Hu, S.-Q., Gu, Y., Wei, L., Liu, S.-S., Zhang, A.-Q. 2007. Immunotoxicity of 

bisphenol A to Carassicus auratus lymphocytes and macrophages following in vitro exposure. 

J. Env. Sci. 19(2): 232-237. 

Ying, G.-G., Kookana, R.S., Kumar, A., Mortimer, M. 2009. Occurrence and implications of 

estrogens and xenoestrogens in sewage effluents and receiving waters from South East 

Queensland. Sci Total Env. 407(18): 5147-5155. 

Ying, G.-G., Kookana, R.S., Kumar, A., Mortimer, M. 2009. Occurrence and implications of 

estrogens and xenoestrogens in sewage effluents and receiving waters from South East 

Queensland. Sci. Total Env. 407(18): 5147-5155. 

Yordy, J.E., Wells, R.S., Balmer, B.C., Schwacke, L.H., Rowles, T.K., Kucklick, J.R. 2010. 

Life history as a source of variation for persistent organic pollutant (POP) patterns in a 

community of common bottlenose dolphins (Tursiops truncatus) resident to Sarasota Bay, FL. 

Sci. Total Env. 408(9): 2163-2172. 

Yu, I.T., Rhee, J.-S., Raisuddin, S., Lee, J.-S. 2008. Characterization of the glutathione Stransferase-Mu (GSTM) gene sequence and its expression in the hermaphroditic fish, 

Kryptolebias marmoratus as a function of development, gender type and chemical exposure. 

Chemico-Biol. Inter. 174(2): 118-125. 

Yu, Y., Zhai, H., Hou, S., Sun, H. 2009. Nonylphenol ethoxylates and their metabolites in 

sewage treatment plants and rivers of Tianjin, China. Chemos. 77(1): 1-7.

Zaccaroni, A., Gamberoni, M., Mandrioli, L., Sirri, R., Mordenti, O., Scaravelli, D., Sarli, G., 

Parmeggiani, A. 2009. Thyroid hormones as a potential early biomarker of exposure to 4-

nonylphenol in adult male shubunkins (Carassius auratus). Sci. Total Env. 407(10): 3301-3306. 

Zhang, C., Zeng, G., Yuan, L., Yu, J., Li, J., Huang, G., Xi, B., Liu, H. Aerobic degradation of 

bisphenol A by Achromobacter xylosoxidans strain B-16 isolated from compost leachate of 

municipal solid waste. Chemos. 68(1): 181-190. 

Zhang, H., Chang, C.-H., Lü, F., Lee, D.-J., He, P.-J., Shao, L.-M., Su, A. 2009. Estrogenic 

activity of fractionate landfill leachate. Sci. Total Env. 407(2): 879-886. 
U.S. Environmental Protection Agency December 2010

40

Zhang, H., Kong F.-X, Wang S.-H., Yu, Y., Zhang, M., Chen, M.-J., Tan X., Qian, S.-Q. 2008. 

Mixture effects to vitellogenin induction by four environmental estrogens in freshwater fish. 

Huanjing Kexue 29(7): 2005-2011. 

Zhang, H., Kong, F., Wang, S., Yu, Y., Zhang, M., Chen, M., Tan, X. 2008. Prediction and 

assessment of the combination effects to a mixture of estrogenic chemicals on freshwater fish. 

Huanjing Kexue Xuebao 28(6): 1178-1185. 

Zhang, X., Hecker, M., Park, J.-W., Tompsett, A.R., Newsted, J., Nakayama, K., Jones, P.D., 

Au, D., Kong, R., Wu, R.S.S., Giesy, J.P. 2008. Real-time PCR array to study effects of 

chemicals on the Hypothalamic–Pituitary–Gonadal axis of the Japanese medaka. Aqua. Tox. 

88(3): 173-182. 

Zhang, X., Li, Q., Li, G., Wang, Z., Yan, C. 2009. Levels of estrogenic compounds in Xiamen 

Bay sediment, China. Mar. Poll. Bull. 58(8): 1210-1216. 

Zhang, X., Oakes, K.D., Cui, S., Bragg, L., Servos, M.R., Pawliszyn, J. 2010. Tissue-Specific 

In Vivo Bioconcentration of Pharmaceuticals in Rainbow Trout (Oncorhynchus mykiss) Using 

Space-Resolved Solid-Phase Microextraction. Env. Sci. Tech. 44(9): 3417-3422. 

Zhang, Y.-Z., Tang, C.-Y., Song, X.-F., Li ,F.-D. 2009. Behavior and fate of alkylphenols in 

surface water of the Jialu River, Henan Province, China. Chemos. 77(4): 559-565.

Zhang, Z., Wu, Z., He, L. 2008. The accumulation of alkylphenols in submersed plants in 

spring in urban lake, China. Chemos. 73(5): 859-863.

Zhao, J.-L., Ying, G.-G., Wang, L., Yang, J.-F., Yang, X.-B., Yang, L.-H., Li, X. 2009. 

Determination of phenolic endocrine disrupting chemicals and acidic pharmaceuticals in 

surface water of the Pearl Rivers in South China by gas chromatography–negative chemical 

ionization–mass spectrometry. Sci. Total Env. 407(2): 962-974.

Zhao, R.B., Sun, D.Y., Fu, S., Wang, X.F., Zhao, R.S. 2007. Bioconcentration kinetics of 

PCBs in various parts of the lifecycle of the tadpoles Xenopus laevis. J. Env. Sci. 19(3): 374-

384. 

Zhou, J., Cai, Z.-H., Li, L., Gao, Y.-F., Hutchinson, T.H. 2010. A proteomics based approach 

to assessing the toxicity of bisphenol A and diallyl phthalate to the abalone (Haliotis 

diversicolor supertexta). Chemos. 79(5): 595-604. 

Zhou, X., Okamura, H., Nagata, S. 2007. Abiotic degradation of triphenylborane pyridine 

(TPBP) antifouling agent in water. Chemos. 67(10): 1904-1910. 

Zhu, H., Rusyn, I., Richard, A., Tropsha, A. 2008. Use of cell viability assay data improves 

the prediction accuracy of conventional quantitative structure-activity relationship models of 

animal carcinogenicity. Env. Health Persp. 116(4): 506-513. 
U.S. Environmental Protection Agency December 2010

41

Zhu, L., Duan Z., Zhu L., Zhang B., Yao, K. 2007. Bioaccumulation and toxicity of bisphenol 

A in zebrafish (Danio rerio) embryo. Progress in Environmental Science and Technology Vol. 

I, Science Press Beijing, Beijing, People’s Republic of China: 115-120.