### Federal Register / Vol. 47, No. 233 /Friday, December 3, 1982 / Notices

ENVIRONMENTAL PROTECTION
AGENCY [OPTS-41010; TSH-FRL 2254-7]

Eleventh Report ofthe Interagency Testing Committee tothe Administrator; Receipt of Report and Request for Comments Regarding PriorityListof Chemicals

AGENCY: Environmental Protection Agency (EPA). ACTION: Notice.
SUM.MARY: The Interagency Testing Committee (ITC), established under section 4(e) ofthe Toxic Substances Control Act (TSCA), transmitted its Eleventh Report to the Administrator of EPA on November 3,1982. This report, which revises and updates the Committee's priority list ofchemicals, adds eleven designated chemicals and

one recommended group ofchemicals to the list forpriority consideration by EPA in the promulgation oftest rules under section 4(a) ofthe Act. The new chemicals are seven alkyltin compounds; bis(2- ethylhexyl)terephthalate; 1,3-dioxolane; 4-(1,1,3,3-tetramethylbutyl)phenol; tris(2- ethylhexyl) trimellitate; and agroup of three carbofuran intermediates. The Eleventh Report is included in this notice. The Agency invites interested persons to submitwritten comments on the Report, and to attend Focus Meetings to help narrow and focus the issues raised by the ITC's recommendations. Members of the public are also invited to inform EPA if they wish to be notified of subsequent public meeting on these chemicals. EPA also notes the removal ofthree chemicals from the priority list because EPA has responded to the ITC's prior recommendations for testing ofthe chemicals. DATES: Written comments should be submitted by January 3, 1983. Focus meetings will be held on January 11, 12, and 13, 1983. ADDRESSES: Send written submissions to; Document Control Officer (TS-793), Office ofPesticides and Toxic Substances, Environmental Protection Agency, Rm. E-409, 401 M St., SW., Washington, DC 20460.

Submissions should bear the Document Control Number OPTS-41010. The public record supporting this action, including comments, is available for public inspection in Rm. E-107 at the address noted above from 8:00 a.m. to 4:00 p.m. Monday through Friday, except legal holidays. Focus meetings will be held at Waterside Mall, in Rm. 3906,401 M St., SW., Washington, DC. Ifyou plan 

### to attend one ofthe Focus Meetings and/or wish to be informed of subsequent public meetings on these chemicals, please notify the Industry Assistance Office at the address listed below.

FOR FURTHER INFORMATION CONTACT: 

### Douglas G.Bannerman, Acting Director, Industry Assistance Office (TS-799), Office ofToxic Substances, Environmental Protection Agency, 401 M Street, SW., Washington,DC 20460, Toll Free: (800-424-9065), InWashington, DC: (554-1404), Outside theUSA: (Operator-202-554-1404).

SUPPLEMENTARY INFORMATION: 

### I.Background

Sec. 4(a) ofTSCA (Pub. L.94-469, 90 Stat.2003 etseq.;15 U.S.C. 2601 etseq.) authorizes theAdministrator ofEPA to promulgate regulations requiring testing ofchemical substances and mixtures in order to develop data relevant to determining the risk that such substances and mixtures may present to health and the environment.

Sec.4(e) ofTSCA established an Interagency Testing Committee to make recommendations to theAdministrator ofEPA ofchemical substances and mixtures to be given priority consideration for thepromulgation of test rules under sec; 4(a). Sec. 4(e) directs the Committee to revise its listof recommendations at least every six months as it determines to be necessary. The ITC may "designate" up to 50 substances and mixtures an any one time for special consideration by the Agency. For such designations, the Agency mustwithin 12 months either initiate rulemaking under sec. 4(a) or issue in the FederalRegister its reasons for not initiatingrulemaking. The ITC's Eleventh Report wasreceived by the Administrator on November 3,1982, and follows this Notice. The report designates 11 substances for consideration and response by EPA within 12 months and recommends one group ofsubstances for consideration which is not subject to the 12 month requirement.
II.WrittenandOral Comments and Public Meetings

EPA.invites interested persons to submit detailed comments on the ITC's

new recommendations. The Agency is interested in receiving information concerning additional or ongoing health and safety studies on the subject chemicals as well as information relating to the human and environmental exposure to these chemicals. Anotice is published elsewhere in today's Federal Register adding the 11 substances designated in the ITC's Eleventh Report to the TSCA section 8(d) rule. The section 8(d) rule requires thereporting of unpublished health and safety studies

on the listed chemicals. The nondesignated carbofuran intermediates will be separately proposed foraddition to the section 8(d)rule.

Focus Meetings will be held to discuss relevant issues pertaining to the chemicals and to narrow the range of issues/effects which will be the focus of the Agency's subsequent activities in responding to the ITC recommendations. The Focus Meetings willbe held January 11, 12, and 13, 1983, at Waterside Mall, 401 M St., SW., Washington, DC, Room 3906. These meetings are intended to supplement and expand upon written
comments submitted in response to this notice. In addition to discussing

concerns and data, the Focus Meetings will explore the issues ofnegotiated testing versus issuance ofa test rule. The schedule for the Focus meetings is the following: January 11, 9:00a.m.- alkyltin compounds, 1:00p.m.-bis(2- ethylhexyl) terephthalate and tris(2- ethylhexyl) trimellitate; January 12, 9:00 a.m.-1,3-dioxolane, 1:00p.m.-4- (1,1,3,3,-tetramethylbutyl) phenol; January 13, 9:00 a.m.-carbofuran intermediates. Persons wishing to attend

one ormore ofthese meetings should call the Industry Assistance Office at the toll free number listed above.

After consideration ofthe data pertaining to each chemical, and any additional information provided in the written comments and the Focus Meetings, EPAwill hold public meetings

on each chemical after preliminary decisions have been made on the types oftesting that are needed. These meetings will be several months in the future, but separate notices ofthese meetings will not be published later. Therefore, anyone wishing to attend these later meetings should contact EPA

now at the address given forthe Industry Assistance Office in orderto be notified in advance of the public meetings.

All written submissions should bear the identifying Docket No. OPTS-41010.

III. Status of List

In addition to adding the 11 designations and one recommendation to the priority list, the ITC's Eleventh Report notes the removal ofone chemical, chlorendic acid, from the list since the last ITC report because EPA has responded to the Committee's prior recommendation for testing ofthe chemical. Subsequent to the ITC's preparation of itsEleventh Report, EPA responded to the ITC's 

### 54626

### Federal Register / Vol. 47, No. 233 / Friday, December 3, 1982 / Notices

recommendations for two additional chemicals. The three chemicals removed and the dates ofpublication ofEPA's responses in the Federal Register are: chlorendic acid, October ;12, 1982 (47FR 44878); 4-chlorobenzotrifluoride, November 8, 1982 (47 FR 50555); and tris(2-chloroethyl)phosphite, November 1, 1982 (47 FR 49466). The current list contains 42 designated substances or categories of substances and two recommended categories of substances.

Dated: November 15,1982. Edwin L.Johnson. ActingAssistant Administrator forPesticides andToxicSubstances. 

### Eleventh Reportofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency Summary

Section 4 ofthe Toxic Substances Control Act of1976 (TSCA, Public Law 94-469) provides for the testing of chemicals in commerce that may present
an unreasonable risk ofinjury to health

or the environment. It also provides for the establishment ofa Committee, composed ofrepresentatives from eight designated Federal agencies, to recommend chemical substances and mixtures (chemicals)to which the Administrator ofthe US. Environmental Protection Agency (EPA) should give priority consideration for the promulgation oftesting rules.

Section 4(e)[1)(A) ofTSCA directs the Committee to recommend to the EPA Administrator chemicals to which the Administrator should give priority consideration for the promulgation of testing rulespursuant to section 4(a). The Committee is required to designate .thosechemicals, from among its recommendations, to which the Administrator should respond within 12 months by either initiating a rulemaking proceeding under section 4(a) or publishing the Administrator's reason for not initiating such a proceeding. Every 6 months, the Committee makes those revisions in the TSCA section 4(e) Priority List that itdetermines to be necessary and transmits them to the EPA Administrator.

As a resultofits deliberations, the Committee is revising the TSCA section 4(e) Priority List by the addition of 11 chemicals and 1group, and the removal of1 chemical. In this report, forthe first time, the Priority List is being divided into two parts: part A contains those recommended chemicals and groups designated forresponse by the EPA Administrator within 12 months, and part B contains chemicals and groups that have been recommended to be considered by EPA for testing-rules promulgation, without being designated for response within 12 months. Although TSCA does not establish a deadline for EPA response to nondesignated chemicals and groups (partB ofthe Priority List), the Committee anticipates that the EPA Administrator will respond in a timely manner.

The entries being added to the Priority List are presented, together with the types oftesting recommended, in the following Table 1.

TABLE 1.-ADDImONS TO THE SECTION 4(E) PRIORITY LIST

Chemical/group Recommended studies

A. Designated for response

within 12 months: Monomethyltin trislisooctyl

mercaptoacetate). Oimethyltin bis-(isoocty

mercaptoacetete).

Monobutytlin trls-(eooctyl

mercaptoacetate). Dibutyltin bis-(isooctyl mercaptoacetate). Dibutyltin bis(atryt mrcaptide). Dibdtyltin dilarat_....._..... Dibutyitin bis-(isooctyl, maleate). Bis(2-ethyhexyl)terephthalate..

1,3-Oioxolane.

4-(1.1.3.3-

Tetramettiylibutyll)pheno.

Tris(2-ethylhexyl)urimellitate

.....

B. Recomnmded, but not

designated for response within 12 months: Carbofuran intermediates. Chemical Fate: Mobility of the compounds from manufacturing and disposal sites; hydrolysis and biodegradation; identification of persistent degradation products. Environmental Effects: Acute

and chronic tmocty to fish and aquatic invertebrates; toxicity to aquatic plants; bKosonosntrabw

Health Effects Mutagenicity;

chemicalt disposition and metabolism; subclvonic effects. En'wonmental Effects and

Chemical Fate: Acute and chronic toxicity to fish and aquatic invertebrates; toxicily to plants; bioconcen. tration, chemical fate. Health Effects: Mutagenicity;

chemical disposition and metabolism; 90-day inhatation toxity. Health Effects: Short-term

tests incliuing mutageni. city- Environmental Effects and

Chemical Fate Acute and droic tmoty to fish and aquatic invertebrates; toxicity to plants;, bioconcenbatior chenical fate. Health Effects: Chemical disposition and metabolism. Environmental Effects and

Chemical Fate: Acute and chronic toxicity to fish and qatic invertebrates; tox- icity to plants; bioconcentration, chemical fate.

Environmental Effects and

Chemical Fate: Acute toxicily to fish and aquatic invertebrates; chemical fate with particular emphasis on monitoring stds.

TSCA Interagency Testing Committee StatutoryMemberAgencies andTheir Representatives Council on Environmental Quality

Gordon F: Snow, Member Department ofCommerce Bernard Greifer, Member Environmental Protection Agency

Joseph Seifter, Member (Deceased) Carl R.Morris,Member' Arthur M. Stem, Alternate' National Cancer Institute

Elizabeth K.Weisburger. Member and

Chairperson Richard Adamson. Alternate Jerrold Ward, Alternate National Institute ofEnvironmental Health Sciences Dorothy Canter. Memnber National Institute for Occupatioral Safety and Health Vera W.Hudson,Member Herbert E.Christensen.Altem3te National Science Foundation

Winston C.Nottingham, Member Occupational Safety andHealth Administration Patricia Marlow. Member
LiaisonAgenciesandTheirRepresentatives Consumer Product Safety'Commission

Arthur Gregory Lakshrni Mishra Department ofAgriculture

Fred W.Clayton Homer E.Fairchild Department.ofDefense

Arthur H. McCreesh Department of the Interior

None Foodand Drug Administration

Winston deMonsabert, Vice Chairperson Allen H1 Heim National Toxcology Program

Dorothy Canter
CommitteeStaff Martin Greif,Executive Secretary. Norma Williams, ITC Coordinator SupportStaff Alan Carpien-Office ofthe General Counsel,

EPA Jon Cooper-Office ofToxic Substances, EPA Joan Lefler--Office ofToxic Substances.

EPA

Notes

(1] Dr. Morris had previously se-ed as an Alternate andwas appointed to fuli-Member status on August 1, 1982, replacing Dr. Joseph Seifter.

(2)Dr. Stemwas appointed as an Alternate

on August 12, 1982.

(3)Ms.Lefler wasappointed on June 14, 1982.

The Committee acknowledges and is grateful for the assistance and support given to it by the staffofDynamac Corporation (technical support contractor) and numerous personnel of the EPA Office ofToxic Substances. Chapter 1-Introduction

1.1 Background. The TSCA Interagency Testing Committee (Committee) was established under section 4(e) ofthe Toxic Substances 54697 R4fi27

### 54628 : Federal Register / Vol. 47, No. 233 / Friday, December 3; 1982 / Notices

Control Act of1976 (TSCA, Public Law 94-469). The specific mandate ofthe Committee is to recommend to the Administrator ofthe U.S. Environmental Protection Agency (EPA) chemical substances and mixtures in commerce that should be given priority consideration forthe promulgation of testing rules to determine their potential hazard to human health and/or the environment. TSCA specifies that the. Committee's recommendations shall be in the form ofa Priority List, which is to be published in theFederal Register. The Committee is directed by section 4(e)(1)(A} ofTSCA to designate those Ichemicals 'onthePriority List to which the EPA Administrator should respond within 12 months by either initiating a rulemaking proceeding under section 4(a) orpublishing the Administrator's

reason for not initiating such a proceeding.

Every 6 months, the Committee makes those revisions in the section 4(e) Priority List that it determines to be necessary and transmits them to the EPA Administrator.

The Committee is comprised of representatives from eight statutory member agencies, five liaison agencies, and one national program. The specific representatives and their affiliajions are named in the front of thisreport. The Committees chemical review procedures and prior recommendations are described in previous reports (Refs. I through 11).

1.2 Committee's previousreports. Ten previous reports to the EPA Administrator have been issued by the Committee and published in the Federal Register (Refs. 2 through 11). Fifty-three entries (chemicals and groups of chemicals) were designated by the Committee forpriority consideration by the EPA Administrator. Eighteen entries

were removed afterEPA responded to the Committee's recommendations for testing, and one wasremoved by the Committee for further consideration (Ref. 10).

1.3 Committee'sactivitiesduring thisreporting period. Thisreport covers activities of the Committee between April 1, 1982, and September 30, 1982.

The Committee has continued to review chemicals from its third scoring exercise (see Ref. 2for methodology) and began reviewing chemicals selected in its fourth scoring exercise. The 

### alkyltin compoundsgroup, which was removed from the Priority List in its ninth report (Ref.10) foradditional consideration by the Committee, has been studied further. Recommendations for the testing ofseven designated alkyltin compounds are included in this report.

The Committee made direct contact with approximately 100 manufacturers ofthe chemicals being reviewed to request information that would be of value in its deliberations. Response by the industry continues to be excellent.

During this reporting period, the Committee has evaluated data on 50 chemicals for priority consideration. Eleven chemicals and one grouphave been added to the section 4(e) Priority List; 16 were deferred from further consideration at this time. The remaining chemicals are still under study.

1.4 The TSCA section4(e)Priority. List.Section 4(e)(j)[B) ofTSCA directs the Committee to:".

. .make such revisions in the [priority] listas it determines to be necessary and... transmit them to the Administrator together with the Committee's reasons for the revisions." Under this authority, the Committee is revising the Priority List by adding 11 chemicals and 1 group: monomethyltin tris(isooctyl mercaptoacetate), dimethyltin bis(isooctyl mercaptoacetate), monobutyltin tris(isooctyl mercaptoacetate), dibutyltin bis(isooctyl mercaptoacetate), dibutyltin bis(lauryl mercaptide), dibutyltin dilaurate, dibutyltin bis(isooctyl maleate), bis(2- ethylhexyl) terephthalate, 1,3-dioxolane, 4-(1,1,3,3-tetramethylbutyl)phenol, tris(2- ethylhexyl) trimellitate, and carbofuran intermediates. The testingrecommended for these chemicals and the rationales for therecommendations are presented in Chapter 2 ofthis report.

One chemical, chlorendic acid, has been removed from the Priority List because the EPA Administrator has responded to the Committee's prior recommendation for testing ofthe chemical.

With the 12 recommendations and 1 removal noted in this report,46 entries

now appear on the section 4(e) Priority List (Table 2). *TABLE 2.-THE TSCA-SECTION 4(E) PRIORITY LIST OCTOBER 1982
IA. Chemicals and Groups Designated for Response Within 12 Months

Date of Entry designation

1.Acetonitrile

.................... Apr. 1979. 2.Acryl anid e ................................................. Apr.-1978. 3. Alkylepoxides

.......................................... Oct 1977. 4. Aniline end bromo-, chioro- and/or Apr. 1979.

nitroanllines.

- 6..Antimony (metal)

................... Do......

........... DO. 6. Antimony (sulfide)....

.............. Do: 7.Antimony tioxide

.......................... ............ Do. 8. Ariy phosphates

.................................... :.

Apr.-1978. 9. Blphenyl

........................................................ Apr. 1982. 10. Bis(2-ethylhexyl) terephthalate

................ Oct. 1982. 11. Chlorinated benzenes, mono- and di-.... Oct. 1977. 12: Chlornated benzenes, tri,tetra-. and Oct. 1978.

penta-. 13. 4-Chlorobenzotrifluorlde

.......................... Oct. 1981. 14. Cresols

. ...... Oct. 1977. 15. Cyc.o.e.....e.................Apr. 1979. 16. Dibutyrn blis(Iooc maleate)

............... Oct. .1982. 17. Dibutyltin bis(isooctyl mercaptoace- Do.

-

tate). 18. Dibutyftinbis(lauryl mercaptilde)

............ Do. 19. Dibutyttindilaurate

............................... : ', Do: 20. 1,2-Dichloropropane

................................. Do. 21. DImethyltin bls(isooctyl mercaptoace- Do.

tate). 22 1.3:Dioxolane

............................................. Do. 23..Ethytoldene

...................... Apr. 1982. 24. Formamide

................................................. DO. 25. Glycidol a itsderivatives

................. Oct. 1978. 26.Halogenated atyl epoxides

.................... Apr. 1978. 27. Hexa;6io-l..3-u a
................... Oct. 1977.. 28. Hexachlorocyclopentadiene.................. Apr. 1979. 29 HydrolUrirne

............................................. Nov..1979. 30. Isophorone

................... Apr. 1979. 31. Mesltyl oxide

........... ................. Do.. 32. 4,4'-Methylenedianiline

.............. . ............. . Do. 33. Methl ethi ketone

......... ........ Do. 34. Methytsbbutyl ketone

............................ Do 35. Monobulyttin tis(isooctyl mercaptoa. Oct. 1982.

cetate). 36. Monomethyltin tris(Isoocty! mercaptoa- Do.

cetate). 37. Pyridine

....................................................... Apr. 1978. 38. Ouligne

...................................................... Nov. 1979. 39. 4-(1.1,3,3-Tetramethylbutyl)phenol

.......... Oct 1982.. 40. Toluene

...................................................... Oct. 1977. 41. 1,2.4-Trtmethylbenzene

............................ Apr. 1982. 42. Tns(2-chtoroethyl) phosphite

.................. Oct. 1981. 43. Tris(2-ethythexyl) trimellitate

.................... Oct. 1982. 44. Xylenes

................ Oct. 1977.

I B.Other Recommended Chemicals and Groups

Er Date of Entry recommendatiqn

1.Carbofuran Intermediates

.......................... Oct. 1982. 2.Tnmethylbenzenes

...................................... Apr. 1982.

The Committee has divided its section 4(e) Priority List into two parts; namely, Table 1A, Chemicals and Groups Designated forResponse Within 12 Months, and Table 1B, Other Recommended Chemicals and Groups. The cumulative list ofentries removed from the Priority List is presented in Table 3.

### Federal Register / Vol. 47, No. 233 / Friday, December 3- 1982 / Notices

Table 3.-Cumulative Removals From the TSCA Section4 (e) Priority-List October 1982

EPA responses to committee recommendations

Federal Register citation Publicatin date

1. AWl/iplthalate.s .o ... .- - - .--. . .. ........................................ .... 48 R 53775.-M3777

... .. .. ..................................................... ........... .......................... Oct. 30, 1981. 2.Allcylincompouds

........................ ..... ....... .. 46 FR 5456-5463

............... ....................................................................... ;......... Feb. 5, 1982. 3. Benzdtne-based dyes

................... . .......... . . ......... . .............................................. 46 FR 55005-55006

.......................................................................................... ....................... Nov. 5, 1981. 4. Beni butyl pl- akste

. ..

y.e...........

... . .............................. . ... 46 FR 55t5-5

............ . ... ...... N 30. 1981.

5. Butyl glycolyl butyl phtha late

. ........................................ 46 FR 54487

.. . . ........................................................................... Nov. 2 1981. 6. Chlorendc acd

......................................... ................... 47 FR 44878-44879

............................................................................................... Oct 12, 1982. 7. chTlorintednaphthalenes

...................... ....... ........................................ ....... . 46 FRI 54491 ....-. . .. . . ..... .................................................... .... ........................- Nov. 2, 1981. 8. hl ted p s ............... ............................... 47 FR 1017-1019....

...................................................... Jan. 8,1982.

9. Chloromethane

.. o.

... . ..... .... ............................................ 45 FR 48524-48564

............................... ........................................................................... . ... July 18. 1980. 10. 2-ChlorotoDluene

................................................................................ 47 FR 18172-18175

. Apr. 28, 1982. 11.od.anisidbie.... dyes

........................... ..... ......................... ... 46 FR 55005-55006

.. .............................................. ... . . Nov. 5. 1981. 12.Di:)chtor d

.... ................................................................. 48 FR 30300-30320

................................................................................................... June 5, 1981. 13. Diethylenetriarnine

.......................................... . ................. .............. ... ... 47FR 18,38.1839t

.. . ................................................... ........... .. ........ . .......... Apr. 29, 1982. 14, Fluoroalkenes

............................................................................................... 46 FR 53704-53708

.. . . . ..................... Oct 30. 1981. 15. Hexac hloroethan e
... ..... ......... . ............... .......................................... 47 FR 18175-18176 8

.... .... ............................................................................. .................. Apr.28, 1982. 16,Ntee zn

..... . . .............................................. 46FR 3 300-3032D

.. . . .... ................................................... ................... ........ June 5, 1981.
17. Phenylenediamtnes

.......... ................................ 47 FR 973-083.....

......................... Jan. 8, 1982. 18. Polyc t pheny

.............. ... ........................ .................... . ......................... 46FR 54482-54483........................................................................................................... Nov. 2, 1981. 19.o-Toliirob sed .y s

. . ....... . .. ...... ............................. 46FR V3005..550

. .. .. .. ................................................................................................... Nov. 5, 1981.
20. .1.1-Trilchroethane

. .. ......................................... . 46FR 30300-30320

......................................................................... ................ June 5, 1981.

'Removed by the committee for reconsideration.

References

(1) Preliminary List ofChemical Substances forFurther Evaluation. Toxic Substances Control ActInteragency Testing Committee, July 1977.

(2) Initial Report to the Administrator, Environmental Protection Agency, TSCA Interagency Testing Committee. October 1, 1977. Publishedin the Federal Register of Wednesday, October 12, 1977, 42 FR 55026- 55080. Corrections published in the Federal' Register ofNovember 11, 1977, 42 FR 58777- 58778.The report and supporting dossiers

were also published by the Environmental Protection Agency, EPA 560-10-78/001, January 1978.

(3) Second Report of the TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, April 1978. Published in the Federal Register of Wednesday, April 19, 1978,43 FR 16684- 16688. Thereport and supporting dossiers

were also published by the Environmental Protection Agency, EPA 560-10-78/002, July 1978.

(4) Third Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, October 1978. Published in the Federal Register of Monday, October 10, 1978,43 FR 50630-50635. The report and supporting dossiers were also published by the Environmental Protection Agency, EPA 560-10-79/001, January 1979.

(5) Fourth Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, April 1979. Published in the Federal Register ofFriday, June 1, 1979, 44 FR 31866-31889.

(6) Fifth Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency.TSCA Interagency Testing Committee, November 1979.Published in the Federal Register of Friday,December 7, 1979, 43 FR 70664-70674.

(7) Sixth Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency.TSCA Interagency Testing Committee, April 1980. Published in the Federal Register of Wednesday, May 28, 1980, 45 FR 35897-35910.

(8) Seventh Report of the TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, October1980. Published in the Federal Register ofTuesday, November 25, 1980, 45 FR 78432-78446.

(9) Eighth Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, April 1981. Published in the.Federal Register ofFriday, May 22, 1981, 46 FR 28138-28144.

(10] Ninth Report ofthe TSCA Interagency Testing Committee to theAdministrator, Environmental Protection Agency. TSCA Interagency Testing Committee, October 1981. Published in the Federal Register of Friday, February 5, 1947, FR 5456-5463.

(11lTenth Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, April 1982. Published in the Federal Register ofTuesday, May 25, 1982, 47 FR 22585-22596.
Chapter 2-Recommendations ofthe 

### Committee

2.1 Chemicalsrecommended for priorityconsideration by theEPA 

### Administrator. As

### provided by section 4(e)(1)(B) ofTSCA, the Committee is adding the following 11 chemicals and 1 group ofchemicals to the section 4(e) Priority List: monomethyltin tris (isooctyl mercaptoacetate), dimethyltin bis(isooctyl mercaptoacetate), monobutyltin tris(isooctyl mercaptoacetate) dibutyltin bis(isooctyl mercaptoacetate), dibutyltin bis(lauryl mercaptide), dibutyltin dilaurate, dibutyltin bis(isooctyl maleate, bis(2- ethylhexyl) terephthalate, 1,3-dioxolane, 4-(1,1,3,3,-tetramethylbutyl)phenol, tris(2-ethylhexyl) trimellitate, and carbofuran intermediates. The recommendation ofthese chemicals is being made after considering the factors identified in section 4(e)(1A) and other available relevant information, as well

as theprofessionaljudgment of Committee members.

The 11recommendations designated for response within 12months are presented in section 2.2 ofthis report. Section 2.3 contains one recommendation with no designated time limit forresponse by the EPA Administrator.

2.2 Chemicalsdesignated for
responsewithin12monthswith supportingretaionales.

2.2.a Alkyltin Compounds. Summaryofrecommended studies.It is recommended that seven specific alkyltin compounds, Monomethyltin tris(isooctyl

mercaptoacetate), dimethyltinbis(isooctyl mercaptoacetate), monobutyltin tris(isooctyl inercaptoacetate), dibutyltin bis(isooctyl mercaptoacetate), dibutyltin bislauryl mercaptide), dibutyltin dilautate, and dibutyltin bis(isooctyl maleate),
be tested for the following:

A. Chemical Fate: Mobility ofthe compounds from manufacturing and disposal sites.

Hydrolysis and biodegradation. Identification ofpersistent degradation products.

B. Environmental Effects: Acute and chronic toxicity to fish and aquatic invertebrates.

Toxicity to aquatic plants. Bioconcentration Background

In the Seventh ITCReport (EPA, 1980), it was recommended to the EPA Administrator that the alkyltin compounds category be given priority 

### 562K9

### Federal Register / Vol. 47, No. 233 / Friday, December 3, 1982 / Notices

consideration forthe promulgation of testing rules.

The category was defined in terms of the following generic formula:

. R

5SnY 4- where: Rrepresents an alkyl group containing one to eight carbon atoms covalently bonded to the tin atom.

n represents the number ofalkylgroups covalently bonded to the tin atom; ncan have a value between I and4. Yrepresents a singly charged anion or anionic organic group bonded tothe tin atom, Sn is the chemical sysmbol forthe element tin. 

### Thirty-three category members were identified in the ITCreport as being either commercially important or of possible commercial significance.

Based oninformation that EPA gathered, analyzed, andpresented tothe Committee subsequent to the ITC recommendation, the Committee concluded that the alkyltin compounds category, as defined in the Seventh ITC Report, was too broad to be considered

as a single category from the standpoint ofchemistry, exposure, oreffects. As a result,inthe NinthITC Report (EPA, 1982a), the Committee removed the alkyltin compounds category from the Priority List and committed itselfto * submitting a revisedrecommendation within 12months.

The Committee has reexamined the 33 alkyltin compounds identified in the Seventh ITCReport plus additional alkyltins in commerce identified by EPA (EPA, 1981) and industry (ORTEP, 1982). Basedon a review of all available information onthese compounds, particularly thelevel ofproduction and type ofuse,the Committee is designating seven alkyltin compounds for priority consideration and deferring the remainder. Physical andChemical Information

Available physical and chemical information on the seven designated alkyltin compounds is given in Table 4.

TABLE4-PHYSICAL AND CHEMICAL PROPERTIES OF SEVEN ALKYLTIN COMPOUNDS

Chemical CAS No. Structuralformula Solubility Vapor pressure Description

Monomethyltin tds(isooctyl) mercapto- 54849-38-6 CH3Sn(SCH-C(O)OC,H,,)

............................................................................................................. 1.0 x10- 4 mmHg

.......... Liquid. acetate). Dimethytin bls(isooctylmercaptoacetate).. 126636-01-1 (CH,),Sn(SCH.C(O)OC.H,,).

.............................. Insoluble inwater,soluble Inorganic

. 2.3 x10- mmHg

......... Clear liquid. Monobutyltn tris(isoocytyl mercaptoace- 25852-70-4 C H.Sn(SCHC(O)OC.H,n)

...................................................................................................................................................... Liquid.

late). Dibutyltin bis(osooctyl mercaptacetat) 225168-24-5 (C.H.),Sn(SCHC(O)OCH,,)............ Insoluble inwater,soluble inorganic

.................... Yellow liquid. Dibutyttin bis(lauryl mercaptide)................... 1185- 81-5 (C H.).Sn(SC,,I H )

. ....................................................................................................................................................... Clear, pale liquid. Dlbytyltin~ 

## ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~~~~~~~~~~~~' disuat

......... e in water............. 7-8- (H)SOCOCH)................... noulinwtr..........

............................... Melting solid t

............... Liquid orlow. Dibytyfln dilaurate..............

............... '177-68-7 (C.),Sn(OC(OIC.M.,)

........................ Inoul.nwte.........Mhn.oidLqi rlw Dibutyhin bis(isooctyl maleate)

........ 25168-21-2 (CHI,)Sn(OC(O)CHCHC(O)OC.H,,)2

................ Insoluble inwater,soluble inpolar

..................................................... White powder.

,Carstab Corp. (1982). 'Solvents. 'Soluble Inbenzene and acetone. 'Melting point at 27 ° C. 5Organic solvents. NOTE.-The log Poctanol/water partition coefficient Is> 6 for all of the above chemicals (estimated by the method of Leo et al., 1971).

Rationale forRecommendations
I.Exposureinformation-A. Production/use/disposal information. The designated.alkyltin compounds are each produced in excess of500,000 pounds per year. Table 5 presents the production data on the recommended compounds assembled from three separate sources: *Public portion of.TSCA Inventory, reporting 1977production levels (EPA, 1982b). "Midwest Research Institute report on organotins (MRI, 1979). "Recent Organotin Environmental Program (ORTEP) submissions, reporting current production levels (ORTEP, 1982).

The seven compounds are among the principal alkyltins used as stabilizers in polyvinyl chloride (PVC) and chlorinated polyvinyl chloride (CPVC), and together they constitute 59 percent of the total alkyltin stabilizer production in the United States (ORTEP, 1982).. Some ofthe compounds are also used as catalysts and sitelimited intermediates. A major use of the PVC and CPVC that is stabilized by these alkyltins is for water pipe, including pipe used to transport potable water (ORTEP, 1982).

BILLING CODE 6560-50-M 

### 54630