**Exhibit 12.1**

 

CERTIFICATION

 

I, Manuel Saba Ades, certifythat:

 

1.          I have reviewed thisannual report on Form 20-F/A (Amendment 2) of Grupo Casa Saba, S.A.B. de C.V. (the “Registrant”);

 

2.          Based on my knowledge,this annual report does not contain any untrue statement of a material fact or omit to state a material fact necessary to makethe statements made, in light of the circumstances under which such statements were made, not misleading with respect to the periodcovered by this annual report;

 

3.          Based on my knowledge,the financial statements, and other financial information included in this annual report, fairly present in all material respectsthe financial condition, results of operations and cash flows of the Registrant as of, and for, the periods presented in this annualreport;

 

4.          The Registrant’sother certifying officers and I are responsible for establishing and maintaining disclosure controls and procedures (as definedin Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules13a-15(f) and 15d-15(f)) for the Registrant and have:

 

(a)          designed such disclosurecontrols and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure thatmaterial information relating to the Registrant, including its consolidated subsidiaries, is made known to us by others withinthose entities, particularly during the period in which this annual report is being prepared;

 

(b)          designed such internalcontrol over financial reporting, or caused such internal control over financial reporting to be designed under our supervision,to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements forexternal purposes in accordance with generally accepted accounting principles;

 

(c)          evaluated the effectivenessof the Registrant’s disclosure controls and procedures and presented in this annual report our conclusions about the effectivenessof the disclosure controls and procedures based on our evaluation, as of the end of the period covered by this annual report; and

 

(d)          disclosed in thisreport any change in the Registrant’s internal control over financial reporting that occurred during the period covered bythis annual report that has materially affected, or is reasonably likely to materially affect, the Registrant’s internalcontrol over financial reporting; and

 

5.          The Registrant’sother certifying officers and I have disclosed, based on our most recent evaluation of internal control over financial reporting,to the Registrant’s auditors and the audit committee of Registrant’s board of directors (or persons performing theequivalent function):

 

(a)          all significant deficienciesor material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adverselyaffect the Registrant’s ability to record, process, summarize and report financial information; and

 

(b)          any fraud, whetheror not material, that involves management or other employees who have a significant role in the Registrant’s internal controlover financial reporting.