Federal Register / Vol. 47, No. 233 / Friday, December 3, 1982 / Notices

ENVIRONMENTAL PROTECTION

AGENCY

[OPTS-41010; TSH-FRL 2254-7]

Eleventh Report of the Interagency

Testing Committee to the

Administrator; Receipt of Report and

Request for Comments Regarding

Priority List of Chemicals

AGENCY: Environmental Protection

Agency (EPA).

ACTION: Notice.

SUM.MARY: The Interagency Testing

Committee (ITC), established under

section 4(e) of the Toxic Substances

Control Act (TSCA), transmitted its

Eleventh Report to the Administrator of

EPA on November 3, 1982. This report,

which revises and updates the

Committee's priority list of chemicals,

adds eleven designated chemicals and

one recommended group of chemicals to

the list for priority consideration by EPA

in the promulgation of test rules under

section 4(a) of the Act. The new

chemicals are seven alkyltin

compounds; bis(2-

ethylhexyl)terephthalate; 1,3-dioxolane;

4-(1,1,3,3-tetramethylbutyl)phenol; tris(2-

ethylhexyl) trimellitate; and a group of

three carbofuran intermediates. The

Eleventh Report is included in this

notice. The Agency invites interested

persons to submit written comments on

the Report, and to attend Focus

Meetings to help narrow and focus the

issues raised by the ITC's

recommendations. Members of the

public are also invited to inform EPA if

they wish to be notified of subsequent

public meeting on these chemicals. EPA

also notes the removal of three

chemicals from the priority list because

EPA has responded to the ITC's prior

recommendations for testing of the

chemicals.

DATES: Written comments should be

submitted by January 3, 1983. Focus

meetings will be held on January 11, 12,

and 13, 1983.

ADDRESSES: Send written submissions

to; Document Control Officer (TS-793),

Office of Pesticides and Toxic

Substances, Environmental Protection

Agency, Rm. E-409, 401 M St., SW.,

Washington, DC 20460.

Submissions should bear the

Document Control Number OPTS-41010.

The public record supporting this action,

including comments, is available for

public inspection in Rm. E-107 at the

address noted above from 8:00 a.m. to

4:00 p.m. Monday through Friday, except

legal holidays. Focus meetings will be

held at Waterside Mall, in Rm. 3906, 401

M St., SW., Washington, DC. If you plan

to attend one of the Focus Meetings

and/or wish to be informed of

subsequent public meetings on these

chemicals, please notify the Industry

Assistance Office at the address listed

below.

FOR FURTHER INFORMATION CONTACT:

Douglas G. Bannerman, Acting Director,

Industry Assistance Office (TS-799),

Office of Toxic Substances,

Environmental Protection Agency, 401 M

Street, SW., Washington, DC 20460, Toll

Free: (800-424-9065), In Washington,

DC: (554-1404), Outside the USA:

(Operator-202-554-1404).

SUPPLEMENTARY INFORMATION:

I. Background

Sec. 4(a) of TSCA (Pub. L. 94-469, 90

Stat. 2003 et seq.; 15 U.S.C. 2601 et seq.)

authorizes the Administrator of EPA to

promulgate regulations requiring testing

of chemical substances and mixtures in

order to develop data relevant to

determining the risk that such

substances and mixtures may present to

health and the environment.

Sec. 4(e) of TSCA established an

Interagency Testing Committee to make

recommendations to the Administrator

of EPA of chemical substances and

mixtures to be given priority

consideration for the promulgation of

test rules under sec; 4(a). Sec. 4(e)

directs the Committee to revise its list of

recommendations at least every six

months as it determines to be necessary.

The ITC may "designate" up to 50

substances and mixtures an any one

time for special consideration by the

Agency. For such designations, the

Agency must within 12 months either

initiate rulemaking under sec. 4(a) or

issue in the Federal Register its reasons

for not initiating rulemaking. The ITC's

Eleventh Report was received by the

Administrator on November 3, 1982, and

follows this Notice. The report

designates 11 substances for

consideration and response by EPA

within 12 months and recommends one

group of substances for consideration

which is not subject to the 12 month

requirement.

II. Written and Oral Comments and

Public Meetings

EPA.invites interested persons to

submit detailed comments on the ITC's

new recommendations. The Agency is

interested in receiving information

concerning additional or ongoing health

and safety studies on the subject

chemicals as well as information

relating to the human and environmental

exposure to these chemicals. A notice is

published elsewhere in today's Federal

Register adding the 11 substances

designated in the ITC's Eleventh Report

to the TSCA section 8(d) rule. The

section 8(d) rule requires the reporting of

unpublished health and safety studies

on the listed chemicals. The

nondesignated carbofuran intermediates

will be separately proposed for addition

to the section 8(d) rule.

Focus Meetings will be held to discuss

relevant issues pertaining to the

chemicals and to narrow the range of

issues/effects which will be the focus of

the Agency's subsequent activities in

responding to the ITC recommendations.

The Focus Meetings will be held January

11, 12, and 13, 1983, at Waterside Mall,

401 M St., SW., Washington, DC, Room

3906. These meetings are intended to

supplement and expand upon written

comments submitted in response to this

notice. In addition to discussing

concerns and data, the Focus Meetings

will explore the issues of negotiated

testing versus issuance of a test rule.

The schedule for the Focus meetings is

the following: January 11, 9:00 a.m.-

alkyltin compounds, 1:00 p.m.-bis(2-

ethylhexyl) terephthalate and tris(2-

ethylhexyl) trimellitate; January 12, 9:00

a.m.-1,3-dioxolane, 1:00 p.m.-4-

(1,1,3,3,-tetramethylbutyl) phenol;

January 13, 9:00 a.m.-carbofuran

intermediates. Persons wishing to attend

one or more of these meetings should

call the Industry Assistance Office at

the toll free number listed above.

After consideration of the data

pertaining to each chemical, and any

additional information provided in the

written comments and the Focus

Meetings, EPA will hold public meetings

on each chemical after preliminary

decisions have been made on the types

of testing that are needed. These

meetings will be several months in the

future, but separate notices of these

meetings will not be published later.

Therefore, anyone wishing to attend

these later meetings should contact EPA

now at the address given for the

Industry Assistance Office in order to be

notified in advance of the public

meetings.

All written submissions should bear

the identifying Docket No. OPTS-41010.

III. Status of List

In addition to adding the 11

designations and one recommendation

to the priority list, the ITC's Eleventh

Report notes the removal of one

chemical, chlorendic acid, from the list

since the last ITC report because EPA

has responded to the Committee's prior

recommendation for testing of the

chemical. Subsequent to the ITC's

preparation of its Eleventh Report, EPA

responded to the ITC's

54626
Federal Register / Vol. 47, No. 233 / Friday, December 3, 1982 / Notices

recommendations for two additional

chemicals. The three chemicals removed

and the dates of publication of EPA's

responses in the Federal Register are:

chlorendic acid, October ;12, 1982 (47 FR

44878); 4-chlorobenzotrifluoride,

November 8, 1982 (47 FR 50555); and

tris(2-chloroethyl)phosphite, November

1, 1982 (47 FR 49466). The current list

contains 42 designated substances or categories of substances and two

recommended categories of substances.

Dated: November 15,1982.

Edwin L. Johnson.

Acting Assistant Administrator for Pesticides

and Toxic Substances.

Eleventh Report of the TSCA

Interagency Testing Committee to the

Administrator, Environmental Protection

Agency

Summary

Section 4 of the Toxic Substances

Control Act of 1976 (TSCA, Public Law

94-469) provides for the testing of

chemicals in commerce that may present an unreasonable risk of injury to health

or the environment. It also provides for

the establishment of a Committee,

composed of representatives from eight

designated Federal agencies, to

recommend chemical substances and

mixtures (chemicals) to which the

Administrator of the US. Environmental

Protection Agency (EPA) should give

priority consideration for the

promulgation of testing rules.

Section 4(e)[1)(A) of TSCA directs the

Committee to recommend to the EPA

Administrator chemicals to which the

Administrator should give priority

consideration for the promulgation of

testing rules pursuant to section 4(a).

The Committee is required to designate

.those chemicals, from among its

recommendations, to which the

Administrator should respond within 12

months by either initiating a rulemaking

proceeding under section 4(a) or publishing the Administrator's reason

for not initiating such a proceeding.

Every 6 months, the Committee makes

those revisions in the TSCA section 4(e)

Priority List that it determines to be

necessary and transmits them to the

EPA Administrator.

As a result of its deliberations, the

Committee is revising the TSCA section

4(e) Priority List by the addition of 11

chemicals and 1 group, and the removal

of 1 chemical. In this report, for the first

time, the Priority List is being divided

into two parts: part A contains those

recommended chemicals and groups

designated for response by the EPA

Administrator within 12 months, and

part B contains chemicals and groups

that have been recommended to be

considered by EPA for testing-rules

promulgation, without being designated

for response within 12 months. Although

TSCA does not establish a deadline for

EPA response to nondesignated

chemicals and groups (part B of the

Priority List), the Committee anticipates

that the EPA Administrator will respond

in a timely manner. The entries being added to the Priority

List are presented, together with the

types of testing recommended, in the

following Table 1.

TABLE 1.-ADDImONS TO THE SECTION 4(E)

PRIORITY LIST

Chemical/group Recommended studies

A. Designated for response

within 12 months :

Monomethyltin trislisooctyl

mercaptoacetate).

Oimethyltin bis-(isoocty

mercaptoacetete).

Monobutytlin trls-(eooctyl

mercaptoacetate).

Dibutyltin bis-(isooctyl mercaptoacetate).

Dibutyltin bis(atryt mrcaptide).

Dibdtyltin dilarat_....._.....

Dibutyitin bis-(isooctyl, maleate).

Bis(2-ethyhexyl)terephthalate..

1,3-Oioxolane.

4-(1.1.3.3-

Tetramettiylibutyll)pheno.

Tris(2-ethylhexyl)urimellitate .....

B. Recomnmded, but not

designated for response

within 12 months:

Carbofuran intermediates.

Chemical Fate: Mobility of

the compounds from manufacturing and disposal

sites; hydrolysis and biodegradation; identification of

persistent degradation

products.

Environmental Effects: Acute

and chronic tmocty to fish and aquatic invertebrates;

toxicity to aquatic plants;

bKosonosntrabw

Health Effects Mutagenicity;

chemicalt disposition and

metabolism; subclvonic effects.

En'wonmental Effects and

Chemical Fate: Acute and

chronic toxicity to fish and

aquatic invertebrates; toxicily to plants; bioconcen.

tration, chemical fate.

Health Effects: Mutagenicity;

chemical disposition and

metabolism; 90-day inhatation toxity. Health Effects: Short-term

tests incliuing mutageni.

city- Environmental Effects and

Chemical Fate Acute and

droic tmoty to fish and

aquatic invertebrates; toxicity to plants;, bioconcenbatior chenical fate.

Health Effects: Chemical disposition and metabolism.

Environmental Effects and

Chemical Fate: Acute and

chronic toxicity to fish and

qatic invertebrates; tox- icity to plants; bioconcentration, chemical fate.

Environmental Effects and

Chemical Fate: Acute toxicily to fish and aquatic invertebrates; chemical fate

with particular emphasis on

monitoring stds.

TSCA Interagency Testing Committee

Statutory Member Agencies and Their

Representatives

Council on Environmental Quality

Gordon F: Snow, Member

Department of Commerce

Bernard Greifer, Member

Environmental Protection Agency

Joseph Seifter, Member (Deceased)

Carl R. Morris, Member'

Arthur M. Stem, Alternate'

National Cancer Institute

Elizabeth K. Weisburger. Member and

Chairperson

Richard Adamson. Alternate

Jerrold Ward, Alternate

National Institute of Environmental Health

Sciences

Dorothy Canter. Memnber

National Institute for Occupatioral Safety

and Health

Vera W. Hudson, Member

Herbert E. Christensen. Altem3te

National Science Foundation

Winston C. Nottingham, Member

Occupational Safety and Health

Administration

Patricia Marlow. Member

Liaison Agencies and Their Representatives

Consumer Product Safety'Commission

Arthur Gregory

Lakshrni Mishra

Department of Agriculture

Fred W. Clayton

Homer E. Fairchild

Department.of Defense

Arthur H. McCreesh

Department of the Interior

None

Food and Drug Administration

Winston deMonsabert, Vice Chairperson

Allen H1 Heim

National Toxcology Program

Dorothy Canter

Committee Staff

Martin Greif, Executive Secretary.

Norma Williams, ITC Coordinator

Support Staff

Alan Carpien-Office of the General Counsel,

EPA

Jon Cooper-Office of Toxic Substances, EPA

Joan Lefler--Office of Toxic Substances.

EPA

Notes

(1] Dr. Morris had previously se-ed as an

Alternate and was appointed to fuli-Member

status on August 1, 1982, replacing Dr.

Joseph Seifter.

(2) Dr. Stem was appointed as an Alternate on August 12, 1982.

(3) Ms. Lefler was appointed on June 14,

1982.

The Committee acknowledges and is

grateful for the assistance and support

given to it by the staff of Dynamac

Corporation (technical support

contractor) and numerous personnel of

the EPA Office of Toxic Substances.

Chapter 1-Introduction

1.1 Background. The TSCA

Interagency Testing Committee

(Committee) was established under

section 4(e) of the Toxic Substances

54697

R4fi27
54628 : Federal Register / Vol. 47, No. 233 / Friday, December 3; 1982 / Notices

Control Act of 1976 (TSCA, Public Law

94-469). The specific mandate of the

Committee Administrator is to recommend to the of the U.S. Environmental

Protection Agency (EPA) chemical

substances and mixtures in commerce

that should be given priority

consideration for the promulgation of

testing rules to determine their potential

hazard to human health and/or the

environment. TSCA specifies that the.

Committee's recommendations shall be

in the form of a Priority List, which is to

be published in the Federal Register.

The Committee is directed by section

4(e)(1)(A} of TSCA to designate those

Ichemicals 'on the Priority List to which

the EPA Administrator should respond

within 12 months by either initiating a

rulemaking proceeding under section

4(a) or publishing the Administrator's

reason for not initiating such a

proceeding.

Every 6 months, the Committee makes

those revisions in the section 4(e)

Priority List that it determines to be

necessary and transmits them to the

EPA Administrator.

The Committee is comprised of

representatives from eight statutory

member agencies, five liaison agencies,

and one national program. The specific

representatives and their affiliajions are

named in the front of this report. The

Committees chemical review procedures

and prior recommendations are

described in previous reports (Refs. I

through 11).

1.2 Committee's previous reports.

Ten previous reports to the EPA

Administrator have been issued by the

Committee and published in the Federal

Register (Refs. 2 through 11). Fifty-three

entries (chemicals and groups of

chemicals) were designated by the

Committee for priority consideration by

the EPA Administrator. Eighteen entries

were removed after EPA responded to

the Committee's recommendations for

testing, and one was removed by the

Committee for further consideration

(Ref. 10).

1.3 Committee's activities during

this reporting period. This report covers

activities of the Committee between

April 1, 1982, and September 30, 1982.

The Committee has continued to

review chemicals from its third scoring

exercise (see Ref. 2 for methodology)

and began reviewing chemicals selected

in its fourth scoring exercise. The

alkyltin compoundsgroup, which was

removed from the Priority List in its

ninth report (Ref. 10) for additional

consideration by the Committee, has

been studied further. Recommendations

for the testing of seven designated

alkyltin compounds are included in this

report.

The Committee made direct contact

with approximately 100 manufacturers

of the chemicals being reviewed to

request information that would be of

value in its deliberations. Response by

the industry continues to be excellent.

During this reporting period, the

Committee has evaluated data on 50

chemicals for priority consideration.

Eleven chemicals and one group have

been added to the section 4(e) Priority

List; 16 were deferred from further

consideration at this time. The

remaining chemicals are still under

study.

1.4 The TSCA section 4(e) Priority.

List. Section 4(e)(j)[B) of TSCA directs

the Committee to:". . . make such

revisions in the [priority] list as it

determines to be necessary and...

transmit them to the Administrator

together with the Committee's reasons

for the revisions." Under this authority,

the Committee is revising the Priority

List by adding 11 chemicals and 1 group:

monomethyltin tris(isooctyl

mercaptoacetate), dimethyltin

bis(isooctyl mercaptoacetate),

monobutyltin tris(isooctyl

mercaptoacetate), dibutyltin bis(isooctyl

mercaptoacetate), dibutyltin bis(lauryl

mercaptide), dibutyltin dilaurate,

dibutyltin bis(isooctyl maleate), bis(2-

ethylhexyl) terephthalate, 1,3-dioxolane,

4-(1,1,3,3-tetramethylbutyl)phenol, tris(2-

ethylhexyl) trimellitate, and carbofuran

intermediates. The testing recommended

for these chemicals and the rationales

for the recommendations are presented

in Chapter 2 of this report.

One chemical, chlorendic acid, has

been removed from the Priority List

because the EPA Administrator has

responded to the Committee's prior

recommendation for testing of the

chemical.

With the 12 recommendations and 1

removal noted in this report, 46 entries

now appear on the section 4(e) Priority

List (Table 2).

* TABLE 2.-THE TSCA-SECTION 4(E) PRIORITY

LIST OCTOBER 1982

IA. Chemicals and Groups Designated for

Response Within 12 Months

Date of Entry designation

1. Acetonitrile .................... Apr. 1979.

2. Acryl anid e ................................................. Apr.- 1978. 3. Alkyl epoxides .......................................... Oct 1977.

4. Aniline end bromo-, chioro- and/or Apr. 1979.

nitroanllines. -

6..Antimony (metal) ................... ........... Do...... DO.

6. Antimony (sulfide).... .............. Do:

7. Antimony tioxide .......................... ............ Do.

8. Ariy phosphates .................................... :. Apr.-1978.

9. Blphenyl ........................................................ Apr. 1982.

10. Bis(2-ethylhexyl) terephthalate ................ Oct. 1982.

11. Chlorinated benzenes, mono- and di-.... Oct. 1977.

12: Chlornated benzenes, tri, tetra-. and Oct. 1978.

penta-.

13. 4-Chlorobenzotrifluorlde .......................... Oct. 1981.

14. Cresols . ...... Oct. 1977.

15. Cyc.o.e.....e.................Apr. 1979.

16. Dibutyrn blis(Iooc maleate) ............... Oct. .1982.

17. Dibutyltin bis(isooctyl mercaptoace- Do. -

tate).

18. Dibutyftin bis(lauryl mercaptilde) ............ Do.

19. Dibutyttin dilaurate ............................... : ', Do:

20. 1,2-Dichloropropane ................................. Do.

21. DImethyltin bls(isooctyl mercaptoace- Do.

tate).

22 1.3:Dioxolane ............................................. Do.

23..Ethytoldene ...................... Apr. 1982.

24. Formamide ................................................. DO.

25. Glycidol a its derivatives ................. Oct. 1978.

26. Halogenated atyl epoxides .................... Apr. 1978.

27. Hexa;6io-l..3-u a ................... Oct. 1977..

28. Hexachlorocyclopentadiene.................. Apr. 1979.

29 HydrolUrirne ............................................. Nov..1979.

30. Isophorone ................... Apr. 1979.

31. Mesltyl oxide ........... ................. Do..

32. 4,4'-Methylenedianiline .............. . ............. . Do.

33. Methl ethi ketone ......... ........ Do.

34. Methytsbbutyl ketone ............................ Do

35. Monobulyttin tis(isooctyl mercaptoa. Oct. 1982.

cetate).

36. Monomethyltin tris(Isoocty! mercaptoa- Do.

cetate).

37. Pyridine ....................................................... Apr. 1978.

38. Ouligne ...................................................... Nov. 1979.

39. 4-(1.1,3,3-Tetramethylbutyl)phenol .......... Oct 1982..

40. Toluene ...................................................... Oct. 1977.

41. 1,2.4-Trtmethylbenzene ............................ Apr. 1982.

42. Tns(2-chtoroethyl) phosphite .................. Oct. 1981.

43. Tris(2-ethythexyl) trimellitate .................... Oct. 1982.

44. Xylenes ................ Oct. 1977.

I B. Other Recommended Chemicals and

Groups

Er Date of Entry recommendatiqn

1. Carbofuran Intermediates .......................... Oct. 1982.

2. Tnmethylbenzenes ...................................... Apr. 1982.

The Committee has divided its section

4(e) Priority List into two parts; namely,

Table 1A, Chemicals and Groups

Designated for Response Within 12

Months, and Table 1B, Other

Recommended Chemicals and Groups.

The cumulative list of entries removed

from the Priority List is presented in

Table 3.
Federal Register / Vol. 47, No. 233 / Friday, December 3- 1982 / Notices

Table 3.-Cumulative Removals From the TSCA Section 4 (e) Priority-List October 1982

EPA responses to committee recommendations

Federal Register citation Publicatin date

1. AWl/ iplthalate.s .o ... .- - - .--. . .. ........................................ .... 48 R 53775.-M3777 ... .. .. ..................................................... ........... .......................... Oct. 30, 1981.

2. Allcylin compouds ........................ ..... ....... .. 46 FR 5456-5463 ............... ....................................................................... ; ......... Feb. 5, 1982. 3. Benzdtne-based dyes ................... . .......... . . .. ....... . .............................................. 46 FR 55005-55006 .............. ............................................................................ ....................... Nov. 5, 1981. 4. Beni butyl pl- akste y.e........... . .. ... . ..... ......................... . ... 46 FR 55t5-5 ............ . ... ...... N 30. 1981.

5. Butyl glycolyl butyl phtha late . ........................................ 46 FR 54487 .. . . ........................................................................... Nov. 2 1981.

6. Chlorendc acd ......................................... ................... 47 FR 44878-44879 ............................................................................................... Oct 12, 1982. 7. chTlorinted naphthalenes ...................... ....... ........................................ ....... . 46 FRI 54491 ....-. . .. . . ..... .................................................... .... ........................- Nov. 2, 1981. 8. hl ted p s ............... ............................... 47 FR 1017-1019.... ...................................................... Jan. 8, 1982.

9. Chloromethane ..o. ... . ..... .... ............................................ 45 FR 48524-48564 ............................... ........................................................................... .... July 18. 1980.

10. 2-ChlorotoDluene ................................................................................ 47 FR 18172-18175 . Apr. 28, 1982.

11. od.anisidbie.... dyes ........................... ..... ......................... ... 46 FR 55005-55006 .. .............................................. ... . . Nov. 5. 1981.

12. Di:)chtor d .... ................................................................. 48 FR 30300-30320 ................................................................................................... June 5, 1981. 13. Diethylenetriarnine .......................................... . ............................... ... ... 47 FR 18,38.1 839t .. . .. ................................................. ........... .. ........ . .......... Apr. 29, 1982.

14, Fluoroalkenes ............................................................................................... 46 FR 53704-53708 .. . .. ..................... Oct 30. 1981.

15. Hexac hloroethan ... e ..... ......... . ............... .......................................... 47 FR 18175-18176 8 .... .... ............................................................................. .................. Apr. 28, 1982.

16, Ntee zn ..... . . .............................................. 46 FR 3 300-3032D .. . . .... ................................................... ................... ........ June 5, 1981.

17. Phenylenediamtnes .......... ................................ 47 FR 973-083..... ..... .................... Jan. 8, 1982.

18. Polyc t pheny .............. ... ........................ .................... . ......................... 46 FR 54482-54483........................................................................................................... Nov. 2, 1981. 19. o-Toliirob sed s . . ....... . .. ...... .y ............................. 46 FR V3005..550 . .. .. .. ..... .............................................................................................. Nov. 5, 1981.

20. .1.1-Trilchroethane . .. ......................................... . 46 FR 30300-30320 ......................................................................... ................ June 5, 1981.

'Removed by the committee for reconsideration.

References

(1) Preliminary List of Chemical Substances

forFurther Evaluation. Toxic Substances

Control Act Interagency Testing Committee,

July 1977.

(2) Initial Report to the Administrator,

Environmental Protection Agency, TSCA

Interagency Testing Committee. October 1,

1977. Published in the Federal Register of

Wednesday, October 12, 1977, 42 FR 55026-

55080. Corrections published in the Federal'

Register of November 11, 1977, 42 FR 58777-

58778. The report and supporting dossiers

were also published by the Environmental

Protection Agency, EPA 560-10-78/001,

January 1978.

(3) Second Report of the TSCA Interagency

Testing Committee to the Administrator,

Environmental Protection Agency. TSCA

Interagency Testing Committee, April 1978.

Published in the Federal Register of

Wednesday, April 19, 1978,43 FR 16684-

16688. The report and supporting dossiers

were also published by the Environmental

Protection Agency, EPA 560-10-78/002, July

1978.

(4) Third Report of the TSCA Interagency

Testing Committee to the Administrator,

Environmental Protection Agency. TSCA

Interagency Testing Committee, October

1978. Published in the Federal Register of

Monday, October 10, 1978, 43 FR 50630-50635.

The report and supporting dossiers were also

published by the Environmental Protection

Agency, EPA 560-10-79/001, January 1979.

(5) Fourth Report of the TSCA Interagency

Testing Committee to the Administrator,

Environmental Protection Agency. TSCA

Interagency Testing Committee, April 1979.

Published in the Federal Register of Friday,

June 1, 1979, 44 FR 31866-31889.

(6) Fifth Report of the TSCA Interagency

Testing Committee to the Administrator,

Environmental Protection Agency. TSCA

Interagency Testing Committee, November

1979. Published in the Federal Register of

Friday, December 7, 1979, 43 FR 70664-70674.

(7) Sixth Report of the TSCA Interagency

Testing Committee to the Administrator,

Environmental Protection Agency. TSCA

Interagency Testing Committee, April 1980.

Published in the Federal Register of

Wednesday, May 28, 1980, 45 FR 35897-35910.

(8) Seventh Report of the TSCA

Interagency Testing Committee to the

Administrator, Environmental Protection

Agency. TSCA Interagency Testing

Committee, October1980. Published in the

Federal Register of Tuesday, November 25,

1980, 45 FR 78432-78446.

(9) Eighth Report of the TSCA Interagency

Testing Committee to the Administrator,

Environmental Protection Agency. TSCA

Interagency Testing Committee, April 1981.

Published in the. Federal Register of Friday,

May 22, 1981, 46 FR 28138-28144.

(10] Ninth Report of the TSCA Interagency

Testing Committee to the Administrator,

Environmental Protection Agency. TSCA

Interagency Testing Committee, October

1981. Published in the Federal Register of

Friday, February 5, 1947, FR 5456-5463.

(11l Tenth Report of the TSCA Interagency

Testing Committee to the Administrator,

Environmental Protection Agency. TSCA

Interagency Testing Committee, April 1982.

Published in the Federal Register of Tuesday,

May 25, 1982, 47 FR 22585-22596.

Chapter 2-Recommendations of the

Committee

2.1 Chemicals recommended for

priority consideration by the EPA

Administrator. As provided by section

4(e)(1)(B) of TSCA, the Committee is

adding the following 11 chemicals and 1

group of chemicals to the section 4(e)

Priority List: monomethyltin tris

(isooctyl mercaptoacetate), dimethyltin

bis(isooctyl mercaptoacetate),

monobutyltin tris(isooctyl

mercaptoacetate) dibutyltin bis(isooctyl

mercaptoacetate), dibutyltin bis(lauryl

mercaptide), dibutyltin dilaurate,

dibutyltin bis(isooctyl maleate, bis(2-

ethylhexyl) terephthalate, 1,3-dioxolane,

4-(1,1,3,3,-tetramethylbutyl)phenol,

tris(2-ethylhexyl) trimellitate, and

carbofuran intermediates. The

recommendation of these chemicals is

being made after considering the factors

identified in section 4(e)(1A) and other

available relevant information, as well

as the professional judgment of

Committee members.

The 11 recommendations designated

for response within 12 months are

presented in section 2.2 of this report.

Section 2.3 contains one

recommendation with no designated

time limit for response by the EPA

Administrator.

2.2 Chemicals designated for

response within 12 months with

supporting retaionales.

2.2.a Alkyltin Compounds.

Summary of recommended studies. It

is recommended that seven specific

alkyltin compounds,

Monomethyltin tris(isooctyl

mercaptoacetate),

dimethyltin bis(isooctyl mercaptoacetate),

monobutyltin tris(isooctyl inercaptoacetate),

dibutyltin bis(isooctyl mercaptoacetate),

dibutyltin bislauryl mercaptide),

dibutyltin dilautate, and

dibutyltin bis(isooctyl maleate),

be tested for the following:

A. Chemical Fate:

Mobility of the compounds from

manufacturing and disposal sites.

Hydrolysis and biodegradation.

Identification of persistent

degradation products.

B. Environmental Effects:

Acute and chronic toxicity to fish and

aquatic invertebrates.

Toxicity to aquatic plants.

Bioconcentration

Background

In the Seventh ITC Report (EPA, 1980),

it was recommended to the EPA

Administrator that the alkyltin

compounds category be given priority

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Federal Register / Vol. 47, No. 233 / Friday, December 3, 1982 / Notices

consideration for the promulgation of

testing rules.

The category was defined in terms of

the following generic formula: .

R5SnY4-

where:

R represents an alkyl group containing one to

eight carbon atoms covalently bonded to

the tin atom.

n represents the number of alkyl groups

covalently bonded to the tin atom; n can

have a value between I and 4.

Y represents a singly charged anion or

anionic organic group bonded to the tin

atom,

Sn is the chemical sysmbol for the element

tin.

Thirty-three category members were

identified in the ITC report as being

either commercially important or of

possible commercial significance.

Based on information that EPA

gathered, analyzed, and presented to the

Committee subsequent to the ITC

recommendation, the Committee

concluded that the alkyltin compounds

category, as defined in the Seventh ITC

Report, was too broad to be considered

as a single category from the standpoint

of chemistry, exposure, or effects. As a

result, in the Ninth ITC Report (EPA,

1982a), the Committee removed the

alkyltin compounds category from the

Priority List and committed itself to *

submitting a revised recommendation

within 12 months.

The Committee has reexamined the 33

alkyltin compounds identified in the

Seventh ITC Report plus additional

alkyltins in commerce identified by EPA

(EPA, 1981) and industry (ORTEP, 1982).

Based on a review of all available

information on these compounds,

particularly the level of production and

type of use, the Committee is

designating seven alkyltin compounds

for priority consideration and deferring

the remainder.

Physical and Chemical Information

Available physical and chemical

information on the seven designated

alkyltin compounds is given in Table 4.

TABLE 4-PHYSICAL AND CHEMICAL PROPERTIES OF SEVEN ALKYLTIN COMPOUNDS

Chemical CAS No. Structural formula Solubility Vapor pressure Description

Monomethyltin tds(isooctyl) mercapto- 54849-38-6 CH3Sn(SCH-C(O)OC,H,,) ............................................................................................................. 1.0 x 10- 4 mmHg .......... Liquid.

acetate).

Dimethytin bls(isooctyl mercaptoacetate).. 126636-01-1 (CH,),Sn(SCH.C(O)OC.H,,). .............................. Insoluble in water, soluble In organic . 2.3 x 10- mmHg ......... Clear liquid.

Monobutyltn tris(isoocytyl mercaptoace- 25852-70-4 C H.Sn(SCHC(O)OC.H,n) ...................................................................................................................................................... Liquid.

late).

Dibutyltin bis(osooctyl mercaptacetat) 225168-24-5 (C.H.),Sn(SCHC(O)OCH,,)............ Insoluble in water, soluble in organic .................... Yellow liquid.

Dibutyttin bis(lauryl mercaptide)................... 1185- 81-5 (C H.).Sn(SC,,I H ) . ....................................................................................................................................................... Clear, pale liquid. Dlbytyltin~ ~ ~ ~ ~ ~ ~ ~ 7-8- ~ ~ (H)SOCOCH)................... ~ disuat ~ ......... ~~~~~~~~~~~~' noulinwtr.......... e in water............. .. ............................. Melting solid t ............... Liquid or low. Dibytyfln dilaurate.............. ............... '177-68-7 (C.),Sn(OC(OIC.M.,) ........................ Inoul.nwte.........Mhn.oidLqi rlw

Dibutyhin bis(isooctyl maleate) ........ 25168-21-2 (CHI,)Sn(OC(O)CHCHC(O)OC.H,,)2 ................ Insoluble in water, soluble in polar ..................................................... White powder.

,Carstab Corp. (1982). 'Solvents. 'Soluble In benzene and acetone. 'Melting point at 27° C. 5Organic solvents.

NOTE.-The log P octanol/water partition coefficient Is > 6 for all of the above chemicals (estimated by the method of Leo et al., 1971).

Rationale for Recommendations

I. Exposure information-A.

Production/use/disposal information.

The designated. alkyltin compounds are

each produced in excess of 500,000

pounds per year. Table 5 presents the

production data on the recommended

compounds assembled from three

separate sources:

* Public portion of.TSCA Inventory, reporting

1977 production levels (EPA, 1982b).

" Midwest Research Institute report on

organotins (MRI, 1979).

" Recent Organotin Environmental Program

(ORTEP) submissions, reporting current

production levels (ORTEP, 1982).

The seven compounds are among the

principal alkyltins used as stabilizers in

polyvinyl chloride (PVC) and

chlorinated polyvinyl chloride (CPVC),

and together they constitute 59 percent

of the total alkyltin stabilizer production

in the United States (ORTEP, 1982)..

Some of the compounds are also used as

catalysts and sitelimited intermediates.

A major use of the PVC and CPVC that

is stabilized by these alkyltins is for

water pipe, including pipe used to

transport potable water (ORTEP, 1982).

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