**Exhibit      12.1**

**CERTIFICATION**

|   | 1. | I                  have reviewed this annual report on Form 20-F of Grupo Casa Saba,                  S.A.B.                  de C.V. (the “Registrant”); |
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|   | 2. | Based                  on my knowledge, this annual report does not contain any untrue                  statement                  of a material fact or omit to state a material fact necessary to                  make the                  statements made, in light of the circumstances under which such                  statements                  were made, not misleading with respect to the period covered by                  this                  annual report; |
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|   | 3. | Based                  on my knowledge, the financial statements, and other financial                  information                  included in this annual report, fairly present in all material                  respects                  the financial condition, results of operations and cash flows of                  the                  Registrant as of, and for, the periods presented in this annual                  report; |
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|   | 4. | The                  Registrant’s other certifying officers and I are responsible for                  establishing and maintaining disclosure controls and procedures                  (as                  defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal                  control over financial reporting (as defined in Exchange Act Rules                  13a-15(f) and 15d-15(f)) for the Registrant and we                  have: |
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|   | (a) | designed                  such disclosure controls and procedures, or caused such disclosure                  controls and procedures to be designed under our supervision, to                  ensure                  that material information relating to the Registrant, including                  its                  consolidated subsidiaries, is made known to us by others within                  those                  entities, particularly during the period in which this annual report                  is                  being prepared; |
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|   | (b) | designed                  such internal control over financial reporting, or caused such                  internal                  control over financial reporting to be designed under our supervision,                  to                  provide reasonable assurance regarding the reliability of financial                  reporting and the preparation of financial statements for external                  purposes in accordance with generally accepted accounting                  principles; |
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|   | (c) | evaluated                  the effectiveness of the Registrant’s disclosure controls and procedures                  and presented in this annual report our conclusions about the                  effectiveness of the disclosure controls and procedures based on                  our                  evaluation, as of a date within 90 days prior to the filing date                  of this                  annual report (the “Evaluation Date”);                  and |
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|   | (d) | disclosed                  in this report any change in the Registrant's internal control                  over                  financial reporting that occurred during the period covered by                  this annual                  report that has materially affected, or is reasonably likely to                  materially                  affect, the Registrant's internal control over financial reporting;                  and |
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|   | 5. | The                  Registrant’s other certifying officers and I have disclosed, based on our                  most recent evaluation of internal control over financial reporting,                  to                  the Registrant’s auditors and the audit committee of Registrant’s board of                  directors (or persons performing the equivalent                  function): |
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|   | (a) | all                  significant deficiencies or material weaknesses in the design or                  operation                  of internal control over financial reporting which are reasonably                  likely                  to adversely affect the Registrant’s ability to record, process, summarize                  and report financial information; and |
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|   | (b) | any                  fraud, whether or not material, that involves management or other                  employees who have a significant role in the Registrant’s internal control                  over financial reporting. |
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| Dated:  June                  29, 2007 | By:                   /s/ Manuel Saba Ades Name:  Manuel                  Saba AdesTitle:  Chief                  Executive Officer |
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