# Registration Notice Conditional v.20150320 

# U.S. ENVIRONMENTAL PROTECTION AGENCY

Office of Pesticide Programs

Registration Division (7505P)

1200 Pennsylvania Ave., N.W.

Washington, D.C. 20460 EPA Reg. Number:



# 71512-23 Date of Issuance:



# 7/21/15

NOTICE OF PESTICIDE:

X Registration

Reregistration Term of Issuance:



# Conditional

(under FIFRA, as amended)

Name of Pesticide Product:



# Isofetamid Turf Fungicide

Name and Address of Registrant (include ZIP Code):



# Michael Peplowski

ISK Biosciences Corporation

7470 Auburn Road, Suite A

Concord, OH 44077

Note: Changes in labeling differing in substance from that accepted in connection with this registration must be submitted to and ac cepted by the

Registration Division prior to use of the label in commerce. In any correspondence on this product always refer to the above E PA registration number.



# On the basis of information furnished by the registra nt, the above named pesticide is hereby registered

under the Federal Insecticide, Fungicide and Rodenticide Act.

Registration is in no way to be construed as an en dorsement or recommendation of this product by the

Agency. In order to protect health and the enviro nment, the Administrator, on his motion, may at any

time suspend or cancel the registration of a pesticid e in accordance with the Act. The acceptance of any

name in connection with the registration of a product under this Act is not to be construed as giving the

registrant a right to exclusive use of the name or to its use if it has been covered by others.

This product is conditionally registered in accordance with FIFRA section 3(c)(7)(C). You must comply

with the following conditions:

1. Submit and/or cite all data requ ired for registration/reregistra tion/registration review of your

product under FIFRA when the Agency requires all registrants of similar products to submit such

data.

Signature of Approving Official:



# Tony Kish, Product Manager 22

Fungicide Branch, Registration Division (7505P) Date:



# 7/21/15

EPA Form 8570-6

# Page 2 of 2

EPA Reg. No. 71512-23

Decision No. 474287

2. You are required to submit to the Agency the follo wing three studies: acute oral toxicity to larval

honey bees; chronic oral toxicity to larval honey bees; and chroni c oral toxicity to adult honey

bees. Protocols for each of the chronic studies are required prior to ini tiating the studies. The

protocols are due 3 months from the date of th is Registration Notice. The studies are due 12

months from the date of this Registration No tice. Thus, the 12 months includes submission and

review of both the protocols and data. Your failure to provide these data in a timely or adequate

manner may result in initiation of a cancel lation action against your registration.

3. Make the following label change before you release the product for shipment:

 Revise the EPA Registration Number to read, “EPA Reg. No. 71512-23.”

4. Submit one copy of the final printed label for the record before you release the product for

shipment.

Should you wish to add/retain a reference to the comp any’s website on your label, then please be aware

that the website becomes labeling under the Federal Insec ticide Fungicide and Rodenticide Act and is

subject to review by the Agency. If the website is false or mislead ing, the product would be misbranded

and unlawful to sell or distribu te under FIFRA section 12(a)(1)(E ). 40 CFR 156.10(a)(5) list examples

of statements EPA may consider false or misleading. In addition, re gardless of whether a website is

referenced on your product’s label, claims made on the website may not substantially differ from those

claims approved through the registration process. Ther efore, should the Agency fi nd or if it is brought to

our attention that a website contains false or mislea ding statements or claims substantially differing from

the EPA approved registration, the website will be re ferred to the EPA’s Office of Enforcement and

Compliance.

If you fail to satisfy these data requirements, EPA will consider appropriate regulatory action including,

among other things, cancellation under FIFRA section 6(e). Your release for shipment of the product

constitutes acceptance of these cond itions. A stamped copy of the label is enclosed for your records.

Please also note that the record for this product currently contai ns the following CSF:

 Basic CSF dated 01-04-2013

If you have any questions, please contact Heathe r Garvie by phone at 703-308-0034, or via email at

garvie.heather@epa.gov.

EnclosurePage 1FIRST AIDIf swallowedxCall a poison control center or doctorimmediately for treatment advice.xHave person sip a glass of water if able toswallow.xDo not induce vomiting unless told to do so byapoison control center or doctor.xDo not give anything to an unconscious person.If on skin orclothingxTake off contaminated clothing.xRinse skin immediately with plenty of soap andwater for 15-20 minutes.xCall a poison control center or doctor fortreatment advice.Have the product container or label with you when calling a poisoncontrol center or doctor, or going for treatment.HOT LINE NUMBERFor24-Hour Medical Emergency Assistance(Human or Animal)Call1-888-484-7546.ForChemical Emergency, Spill, Leak, Fire or Accident, CallCHEMTREC 1-800-424-9300.ISOFETAMIDTURF FUNGICIDEACTIVE INGREDIENT: Isofetamid* ................................... 36.0%OTHER INGREDIENTS: ...................................................... 64.0%Total ...................................................................................... 100.0%*N-[1,1-dimethyl-2-[2-methyl-4-(1-methylethoxy)phenyl]-2-oxoethyl]-3-methyl-2-thiophenecarboxamideContains 3.33 pounds Isofetamid Per Gallon (400 grams per liter)KEEP OUT OF REACH OF CHILDRENCAUTIONSee side panel for additional precautionary statements.Read entire label carefully and use only as directed.ISK Biosciences Corporation7470 Auburn Road, Suite AConcord, Ohio 44077 U.S.A.EPA Reg. No. 71512-EG EPA Est. No.Active Ingredient Made in JapanFormulation Made inNet Contents:GROUP 7 FUNGICIDE07/21/201571512-23Page 2PRECAUTIONARY STATEMENTSHAZARDS TO HUMANS AND DOMESTIC ANIMALSCAUTIONHarmful if swallowed or absorbed through skin. Avoid contact withskin, eyes or clothing. Wash thoroughly with soap and water afterhandling and before eating, drinking, chewing gum, using tobacco orusing the toilet. Remove and wash contaminated clothing beforereuse.Personal Protective Equipment (PPE)Applicators and other handlers must wear long-sleeved shirt and longpants, socks, shoes, and chemical resistant gloves made of anywaterproof material.Follow manufacturer’s instructions for cleaning/ maintaining PPE. Ifno such instructions for washables, use detergent and hot water. Keepand wash PPE separately from other laundry.Engineering Control StatementsWhen handlers use closed systems, enclosed cabs, or aircraft in amanner that meets the requirements listed in the Worker ProtectionStandard (WPS) for agricultural pesticides [40 CFR 170.240(d)(4-6)],the handler PPE requirements may be reduced or modified asspecified in the WPS.User Safety RecommendationsUsers should:xWash hands before eating, drinking, chewing gum, using tobaccoor using the toilet.xRemove clothing/PPE immediately if pesticide gets inside. Thenwash thoroughly and put on clean clothing.xRemove PPE immediately after handling this product. Wash theoutside of gloves before removing. As soon as possible, washthoroughly and change into clean clothing.ENVIRONMENTAL HAZARDSThis pesticide is toxic to oysters. DO NOT apply directly to water, orto areas where surface water is present or to intertidal areas below themean high water mark. DO NOT contaminate waters when disposingof equipment washwaters or rinsate. Do not apply when weatherconditions favor drift from the treated areas. Drift and runoff may behazardous to aquatic organisms in water adjacent to treated areas.AVOIDING SPRAY DRIFT AT THE APPLICATION SITE ISTHE RESPONSIBILITY OF THE APPLICATOR. The interactionof many equipment-and-weather-related factors determine thepotential for spray drift. The applicator is responsible forconsidering all these factors when making decisions. Where stateshave more stringent regulations, they must be observed.STORAGE AND DISPOSALDO NOT contaminate water, food or feed by storage or disposal.PESTICIDE STORAGE:Store in original container, in a secured,dry, cool place separate from fertilizer, food, and feed. Avoidcross-contamination with other pesticides.PESTICIDE DISPOSAL:Pesticide wastes may be hazardous.Improper disposal of excess pesticide, spray mixture or rinsate is aviolation of Federal law. If these wastes cannot be disposed of byuse according to label instructions, contact your State Pesticide orEnvironmental Control Agency or the Hazardous Wasterepresentative at the nearest EPA Regional Office for guidance.CONTAINER HANDLING:Nonrefillable container (equal to orless than 5 gallons). DO NOT reuse or refill this container. Triplerinse container (or equivalent) promptly after emptying. Triplerinse as follows: Empty the remaining contents into applicationequipment or a mix tank and drain for 10 seconds after the flowbegins to drip. Fill the container 1⁄4 full with water and recap.Shake for 10 seconds. Pour rinsate into application equipment or amix tank or store rinsate for later use or disposal. Drain for 10seconds after the flow begins to drip. Repeat this procedure twomore times. Then offer for recycling if available, or puncture andPage 3dispose of in a sanitary landfill, or by incineration or, if allowed bystate and local authorities, by burning. If burned, stay out of smoke.Nonrefillable container (greater than 5 gallons). DO NOT reuse orrefill this container. Triple rinse container (or equivalent) promptlyafter emptying. Triple rinse as follows: Empty the remainingcontents into application equipment or a mix tank. Fill thecontainer 1⁄4 full with water. Recap and tighten closures. Tipcontainer on its side and roll it back and forth, ensuring at least onecomplete revolution, for 30 seconds. Stand thecontainer on its endand tip it back and forth several times. Turn thecontainer over onto itsother end and tip it back and forth several times. Empty rinsate intoapplication equipment or a mix tank or store rinsate for later use ordisposal. Repeat this procedure two more times. Then offer forrecycling if available, or puncture and dispose of in a sanitarylandfill, or by incineration or, if allowed by state and localauthorities, by burning. If burned, stay out of smoke.DIRECTIONS FOR USEIt is a violation of Federal law to use this product in a mannerinconsistent with its labeling.DO NOT apply this product in a way that will contact workers orother persons, either directly or through drift. Only protectedhandlers may be in the area during application. For any requirementsspecific to your State or Tribe, consult the agency responsible forpesticide regulation.FAILURE TO FOLLOW THE USE DIRECTIONS ANDPRECAUTIONS ON THIS LABEL MAY RESULT IN PLANTINJURY OR POOR DISEASE CONTROL.ISOFETAMID is a flowable suspension concentrate for control ofdiseases on turf areas associated with golf courses (greens, tees andfairways), sod farms, seed farms, college and professional sportsfields, residential and commercial lawns. Intended for use only byprofessional applicators.AGRICULTURAL USE REQUIREMENTSUse this product only in accordance with its labeling and with theWorker Protection Standard, 40 CFR Part 170. This Standardcontains requirements for the protection of agricultural workers onfarms, forests, nurseries, and greenhouses and handlers of agriculturalpesticides. It contains requirements for training, decontamination,notification, and emergency assistance. It also contains specificinstructions and exceptions pertaining to the statements on this labelabout personal protective equipment (PPE), and restricted-entryinterval. The requirements in this box only apply to uses of thisproduct that are covered by the Worker Protection Standard.DO NOT enter or allow worker entry into treated areas during therestricted entry interval (REI) of twelve (12) hours.PPE required for early entry into treated areas that is permitted underthe Worker Protection Standard and that involves contact withanything that has been treated, such as plants, soil, or water, is:coveralls, chemical resistant gloves made of any waterproof material,shoes plus socks.Sod and seed farms, commercial greenhouses and nurseries arewithin the scope of the Worker Protection Standard.NON-AGRICULTURAL USE REQUIREMENTSThe requirements in this box apply to uses of this product that are notwithin the scope of the Worker Protection Standard for agriculturalpesticides, 40 CFR Part 170. The WPS applies when this product isused to produce agricultural plants on farms, forests, nurseries, orgreenhouses. Turfgrasses on golf courses and other non-residentialturf areas such as industrial parks, tank farms, professionallymanaged college and professional sports fields, commercial lawnsand ornamental landscapes are not within the scope of the WorkerProtection Standard.Keep children, pets, and unprotected persons out of the treated areauntil sprays have dried.Page 4PRODUCT INFORMATIONISOFETAMID is a broad-spectrum fungicide with preventative,systemic and curative properties for the control of dollar spot onturfgrasses. ISOFETAMID should be used in a regularly scheduledpreventative spray program and used in rotation with products witha different mode of action, such as triazoles, ergosterol biosynthesisinhibitors (QoI) or benzimidazoles. For control of other diseasesnot listed on this label, ISOFETAMID may be tank mixed withother fungicides. Tank mixes should follow the use instructions onboth labels for application rate and application timings. Failure tofollow these instructions may results in inferior disease controland/or phytotoxicity.Although ISOFETAMID has been evaluated on several turfgrasscultivars, varieties and hybrids with no indication of phytotoxicity,neither the manufacturer nor seller have determined adequatetolerance on all turfgrass under all conditions. The user shoulddetermine if ISOFETAMID can be used safely for commercial useby applying the labeled rate to a small test area under conditions tobe expected and monitor for adverse effects before applyingISOFETAMID to the targeted area.USE RESTRICTIONSxDo not apply more than 3.2 fl oz/1000 sq ft per year or 140 floz per acre. This is equal to 8 applications at the low rate (0.452lb a.i./A/application) or 6 applications at the high rate (0.567 lba.i./A/application).xDo not applyISOFETAMIDthrough any type of irrigationsystemxDo not applyISOFETAMIDby aerial applicationxIntended for use only by professional applicators.INTEGRATED PEST MANAGEMENTISOFETAMID is an excellent disease control agent when usedaccording to label directions for control of dollar spot on turfgrass.Although ISOFETAMID has preventative, systemic and curativeactivity, it should be applied as a protectant fungicide before visiblesymptoms of the disease occur.Depending upon the level of disease pressure, good protection of theturfgrass can be expected over a period of 14 days.ISOFETAMID is recommended for use as part of an Integrated PestManagement (IPM) program, which may include the use of diseaseresistant crop varieties, cultural practices, biological disease controlagents, pest scouting and disease forecasting systems aimed atpreventing economic pest damage. Practices known to reduce diseasedevelopment should be followed. Consult your state cooperativeextension service or local agricultural authorities for additional IPMstrategies established in your area. ISOFETAMID may be used inState Agricultural Extension advisory (disease forecasting) programsthat recommend application timing based upon environmental factorsthat favor disease development.RESISTANCE MANAGEMENTSome plant pathogens are known to develop resistance to productsused repeatedly for disease control. ISOFETAMID’s mode/targetsite of action is complex II; succinate-dehydrogenase, FRAC Group7. A disease management program that includes alternation or tankmixes between ISOFETAMID and other labeled fungicides thathave a different mode of action and/or control pathogens notcontrolled with ISOFETAMID is essential to prevent diseaseresistant pathogens populations from developing. ISOFETAMIDshould not be utilized continuously nor tank mixed with fungicidesthat have shown to have developed fungal resistance to the targetdisease.Since pathogens differ in their potential to develop resistance tofungicides, follow the directions outlined in the “Directions ForUse” section of this label for specific resistance managementstrategies. Consult with your Federal or State CooperativeExtension Service representatives for guidance on the proper useof ISOFETAMID in programs that seek to minimize theoccurrence of disease resistance. ISOFETAMID is not cross-Page 5resistant with other classes of fungicides that have different modesof action.MIXING AND SPRAYINGFor maximum efficacy ISOFETAMID should be applied prior to orin the very early stages of disease development. ISOFETAMIDmust be applied at the label rates and timings listed in theDirections for Use section in 2 to 4 gallons of water per 1000square feet (87 to 174 gallons per acre).Slowly invert container several times to assure uniform mixture offormulation before adding this product to the spray tank. Therequired amount of ISOFETAMID 400SC should be added slowlyinto the spray tank during filling. With concentrate sprays, pre-mixthe required amount of ISOFETAMID 400SC in a clean containerand add to the spray tank as it is being filled. Keep agitator runningwhen filling spray tank and during spray operations. DO NOTallow spray mixture to stand overnight or for prolonged periods.Prepare only the amount of spray required for immediate use.Spraying equipment should be thoroughly cleaned immediatelyafter the application.Under conditions favorable for disease development, the highestrate specified and shortest application interval should be used.ISOFETAMID may be applied with all types of spray equipmentnormally used for ground applications on turfgrasses.TANK MIX COMPATIBILITYISOFETAMID is physically compatible (no nozzle or screenblockage) with many products labeled for control of diseases andinsects on turfgrasses. Read and follow all manufacturers labelprecautions and restrictions for the tank mix companion product. Itis the applicator’s responsibility to ensure that the companionproduct is EPA approved for use on the intended site.ISOFETAMID is generally compatible with other insecticides,fungicides, adjuvants, fertilizers and micronutrient productsprovided sufficient free water is available for dispersion of all thetank mix products. Under some conditions, the use of adjuvantsand/or surfactants at the rate of 0.025% to 0.1% of the spray tankvolume may improve the performance of ISOFETAMID.However, the physical compatibility of ISOFETMAID with tankmix partners must be evaluated before use. Conduct a jar test withintended tank-mix pesticides prior to preparation of large volumes.Use the following procedure: 1) Pour the recommended proportionsof the products into a suitable container of water; 2) Mix thoroughlyand; 3) Allow to stand for 5 minutes. If the combination remainsmixed or can be re-mixed readily, it is considered physicallycompatible. Any physical incompatibility in the jar test indicatesthat ISOFETAMID should not be used in the tank-mix.User should note that not all turf varieties have been tested with allpossible tank mix combinations. Thus the combination should betested for turf safety on a small portion of the turf to ensure that aphytotoxic response will not occur.Page 6Table 1. Application Rates and IntervalsDisease Rate(fl oz/1000 sq ft)Rate(fl oz / acre)ApplicationInterval(days)CommentsDollar spot(Sclerotinia homoeocarpa)0.4 to 0.5 17.4 to 21.8(0.452 to0.567 lb.a.i./A14 Apply as a preventative treatment prior to or in the very earlystage of development. Use the highest rate during periods ofprolonged favorable disease conditions. Do not apply morethan two consecutive applications of ISOFETAMID or otherGroup 7 containing fungicides before rotating to a registeredfungicide with a different mode of action. Do not apply thenext application of ISOFETAMID within 28 days of theprevious two consecutive ISOFETAMID applications.Table 2. Dilution Table for Applicationsfl oz of ISOFETAMID per 100 gallons of spray solutionsUse Rate(fl oz per 1000 sq ft)Spray Volume2 gallons per 1000 sq ftSpray Volume3 gallons per 1000 sq ftSpray Volume4 gallons per 1000 sq ft0.420 fl oz/ 100 gal 13.3 fl oz/ 100 gal 10 fl oz/ 100 gal0.5 25 fl oz/ 100 gal 16.7 fl oz/ 100 gal 12.5 fl oz/ 100 galWARRANTY AND LIMITATION OF DAMAGESSeller warrants to those persons lawfully acquiring title to this productthat at the time of first sale of this product by Seller that this productconformed to its chemical description and was reasonably fit for thepurposes stated on the label when used in accordance with Seller’sdirections under normal conditions of use. To the extent consistent withapplicable law, Buyers and users of this product assume the risk of anyuse contrary to such directions.EXCEPT AS PROVIDEDELSEWHERE IN WRITING CONTAINING AN EXPRESSREFERENCE TO THIS WARRANTY AND LIMITATION OFDAMAGES, SELLER MAKES NO OTHER EXPRESS ORISK Biosciences Corporation7470 Auburn Road, Suite AConcord, Ohio 44077 U.S.A.IMPLIED WARRANTY OR GUARANTY, INCLUDING ANYOTHER EXPRESS OR IMPLIED WARRANTY OF FITNESS OROF MERCHANTABILITY, AND NO AGENT OF SELLER ISAUTHORIZED TO DO SO.In no event shall Seller’s liability for anybreach of warranty or guaranty exceed the purchase price of the productas to which a claim is made. To the extent consistent with applicable law,Buyers and users of this product are responsible for all loss or damagefrom use or handling of this product which results from conditions beyondthe control of Seller, including, but not limited to, incompatibility withother products unless otherwise expressly provided in Directions for Useof this product, weather conditions, cultural practices, moisture conditionsor other environmental conditions outside of the ranges that are generallyrecognized as being conducive to good agricultural and/or horticulturalpractices.ISOFETAMID - 03202015