<PAGE>
                                                                    EXHIBIT 31.1



              CERTIFICATION OF CHIEF EXECUTIVE OFFICER PURSUANT TO
       EXCHANGE ACT RULES 13A-14(A) AND 15D-14(A), AS ADOPTED PURSUANT TO
                  SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, John G. Lettko, certify that:

   1.   I have reviewed this annual report on Form 10-K of ProxyMed, Inc.;

   2.   Based on my knowledge, this annual report does not contain any untrue
        statement of a material fact or omit to state a material fact necessary
        to make the statements made, in light of the circumstances under which
        the statements were made, not misleading with respect to the period
        covered by this report;

   3.   Based on my knowledge, the financial statements, and other financial
        information included in this report, fairly present in all material
        respects the financial condition, results of operations and cash flows
        of the registrant as of, and for, the periods presented in this report;

   4.   The registrant's other certifying officer and I are responsible for
        establishing and maintaining disclosure controls and procedures (as
        defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal
        control over financial reporting (as defined in Exchange Act Rules
        13a-15f and 15d-15(f)) for the registrant and have:

        a.    designed such disclosure controls and procedures or caused such
              disclosure controls and procedures to be designed under our
              supervision to ensure that material information relating to the
              registrant, including its consolidated subsidiaries, is made known
              to us by others within those entities, particularly during the
              period in which this annual report is being prepared;

        b.    designed such internal control over financial reporting, or caused
              such internal control over financial reporting to be designed
              under our supervision, to provide reasonable assurance regarding
              the reliability of financial reporting and the preparation of
              financial statements for external purposes in accordance with
              generally accepted accounting principles;

        c.    evaluated the effectiveness of the registrant's disclosure
              controls and procedures and presented in this report our
              conclusions about the effectiveness of the disclosure controls and
              procedures, as of the end of the period covered by this report
              based on such evaluation; and

        d.    disclosed in this report any change in the registrant's internal
              control over financial reporting that occurred during the
              registrant's most recent fiscal quarter (the registrant's fourth
              fiscal quarter in the case of the annual report) that has
              materially affected, or is reasonably likely to materially affect,
              the registrant's internal control over financial reporting.

   5.   The registrant's other certifying officer and I have disclosed, based on
        our most recent evaluation of internal control over financial reporting,
        to the registrant's auditors and the audit committee of the registrant's
        board of directors (or persons performing the equivalent function):

        a.    all significant deficiencies and material weaknesses in the design
              or operation of internal control which are reasonably likely to
              adversely affect the registrant's ability to record, process,
              summarize and report financial information; and

        b.    any fraud, whether or not material, that involves management or
              other employees who have a significant role in the registrant's
              internal controls over financial reporting.

Date: March 14, 2006

/s/ JOHN G. LETTKO



 John G. Lettko
Chief Executive Officer