### 8859 Federal Register / Vol. 77, No. 31 / Wednesday, February 15, 2012 / Notices

mother-infant pairs that have reported associations with birth outcomes, childhood neurobehavioral and neurodevelopment outcomes in the offspring when evaluated in neonates, infants, and young children.

In 2008, the FIFRA Scientific Advisory Panel (SAP) reviewed a draft science issue paper on the human health effects of chlorpyrifos which provided a preliminary review of the scientific literature on experimental toxicology and epidemiology studies available at that time. In 2010, the Agency developed a draft ‘‘Framework for Incorporating Human Epidemiologic & Incident Data in Health Risk Assessment’’ which provides the conceptual foundation for evaluating multiple lines of scientific evidence in the context of the understanding of the adverse outcome pathway (or mode of action). This draft framework uses modified Bradford Hill Criteria to evaluate the sufficiency of evidence to establish key events within a mode of action(s) and explicitly considers such concepts as strength, consistency, dose response, temporal concordance and biological plausibility. Since the 2008 SAP on chlorpyrifos, the Agency has performed further analyses on the existing and new epidemiology results in mothers and children, available biomonitoring data, and experimental toxicology studies evaluating proposed adverse outcome pathways in the context of human health risk assessment. Specifically, the Agency is evaluating available literature on the potential for chlorpyrifos to cause long term adverse effects from early life

exposure, in vivo and in vitro studies evaluating mechanistic aspects of chlorpyrifos, and the potential for adverse effects below doses established from ChE inhibition that are used for regulatory purposes. At this time, the Agency is working towards a weight of evidence evaluation integrating the epidemiology studies with the experimental toxicology studies for the neurodevelopmental outcomes. This analysis is complex and multifaceted as it involves different lines of scientific evidence (i.e., in vivo and in vitro experimental toxicology studies, explicit consideration of adverse outcome pathways, exposure, epidemiology, and biomonitoring data). As such, the Agency believes that peer review on the status of the current analysis is important.

C. FIFRA SAP Documents and Meeting

Minutes

EPA’s background paper, related supporting materials, charge/questions to FIFRA SAP, FIFRA SAP composition (i.e., members and ad hoc members for this meeting), and the meeting agendawill be available by approximately midMarch. In addition, the Agency may provide additional background documents as the materials become available. You may obtain electronic copies of these documents, and certain other related documents that might be available electronically, at http:// www.regulations.gov and the FIFRA SAP homepage at http://www.epa.gov/ scipoly/sap.

FIFRA SAP will prepare meeting minutes summarizing its recommendations to the Agency approximately 90 days after the meeting. The meeting minutes will be posted on the FIFRA SAP Web site or may be obtained from the OPP Regulatory Public Docket at http:// www.regulations.gov.

List of Subjects

Environmental protection, Pesticides and pests.

Dated: February 2, 2012.
Frank Sanders, Director, Office of Science Coordination and Policy.

[FR Doc. 2012–3280 Filed 2–14–12; 8:45 am]

**BILLING CODE 6560–50–P**

**ENVIRONMENTAL PROTECTION AGENCY** 

**[FRL–9632–4]**

**National Advisory Council for Environmental Policy and Technology** 

**AGENCY :**  Environmental Protection Agency (EPA).

**ACTION :**  Cancellation and Rescheduling of National Advisory Council for Environmental Policy and Technology (NACEPT) Committee Meeting.

**SUMMARY :**  EPA announced in the Federal Register on January 12, 2012 [FRL–9617–7] a National Advisory Council for Environmental Policy and Technology (NACEPT) Meeting to be held at the EPA Potomac Yard Conference Center, One Potomac Yard, 2777 S. Crystal Drive, Arlington, VA 22202. Under the Federal Advisory Committee Act, Public Law 92463, EPA gives notice of cancellation and rescheduling of that public meeting for the National Advisory Council for Environmental Policy and Technology (NACEPT). NACEPT provides advice to the EPA Administrator on a broad range of environmental policy, technology, and management issues. NACEPT members represent academia, industry, non-governmental organizations, and local, state, and tribal governments. The purpose of this meeting is to begin developing recommendations to the Administrator regarding actions that EPA can take in response to the National Academy of Sciences Report on ‘‘Incorporating Sustainability in the U.S. Environmental Protection Agency.’’ A copy of the agenda for the meeting will be posted at http://www.epa.govofacmo/nacept/calnacept.htm.

**DATES :**  NACEPT has cancelled the twoday public meeting scheduled for February 13, 2012, from February 14,
2012. NACEPT will now hold the twoday public meeting on Monday, March 26, 2012, from 9 a.m. to 5:30 p.m. (EST) and Tuesday, March 27, 2012 from 8:30 a.m. to 2 p.m. (EST).

**ADDRESSES :**  The meeting will be held at the EPA East Building Room 1153, 1201 Constitution Avenue NW., Washington,

DC 20004.

**FOR FURTHER INFORMATION CONTACT :**  Mark Joyce, Acting Designated Federal Officer, joyce.mark@epa.gov, (202) 564– 2130, U.S. EPA, Office of Federal Advisory Committee Management and Outreach (1601M), 1200 Pennsylvania Avenue NW., Washington, DC 20460.

**SUPPLEMENTARY INFORMATION :**  Requests to make oral comments or to provide written comments for the March 26–27, 2012, NACEPT meeting should be sent to Eugene Green at green.eugene@epa.gov by Monday, March 19, 2012. The meeting is open to the public, with limited seating available on a first-come, first-served basis. Members of the public wishing to attend should contact Eugene Green at green.eugene@epa.gov or (202) 564– 2432 by March 19, 2012.

Meeting Access: Information regarding accessibility and/or accommodations for
individuals with disabilities should be directed to Eugene Green at the email address or phone number listed above. To ensure adequate time for processing, please make requests for accommodations at least 10 days prior to the meeting.

Dated: February 7, 2012.
Mark Joyce, Acting Designated Federal Officer.

[FR Doc. 2012–3533 Filed 2–14–12; 8:45 am]

**BILLING CODE 6560–50–P**