UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON , D.C. 20460 

Date: December 03, 2015 

OFFICE OF 

CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

SUBJECT: Hymexazol. Acute and Chronic Dietary Exposure and Risk Assessments of Drinking 

Water to Support Registration Review. 

PC Code: 129107 DP Barcode: 0429383 

Decision No.: 49934 I Registra tion No.: 482 I 0- I 

Petition No.: NA Regulatory Action: Registration Review 

Risk Assessme nt Type: Single Chemical, Dietary Case No.: 7016 

TXR No.: NA CAS No.: 10004-44-1 

MRID No.: None 40 CFR: NA 

FROM: P

Risk 

eter 

Assessment 

Savoia, Chemis

Branch 

t a...-fl 

V {__- h ~ 

THRU: 

Health Effects Division (7509P) 

Danette Drew, Chemist, and /, j Ju; j /) j Michael S. Metzger, Branch chi~ vvtftv--'l ' 

Risk Assessment Branch V 

Health Effects Division (7509P) 

And I i-rWilliam Cutchin, hemist,~/~ • vv&,, L- "\A..c ~ 

Kristin Rury, Biologist ~ 

Dietary Exposure Science Advis ouncil 

Health Effects Division (7509P) 

TO: Matthew Lloyd, Risk Assessor 

Risk Assessment Branch V /VII 

Health Effects Division (7509P) 

And 

Ricardo Jones, Chemical Review Manager 

Risk Management and Implementation Branch I 

Pesticide Re-Evaluation Division (7508P) 

Executive Summary 

Acute and chronic dietary exposure and risk assessments of drinking water only for the fungicide 

hymexazol were conducted using the Dietary Exposure Evaluation Model software with the Food 

Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food 

consumption data from the U.S. Department of Agriculture's (USDA's) National Health and 

Nutrition Examination Survey/What We Eat in America, (NHANES/WWEIA). These analyses 

reflect the latest consumption data for the evaluation of dietary exposure made to support the 

Page I of 11 
Hymexazol Dietary Exposure and Risk Assessment DP No. 0429383 

registration review risk assessment of hymexazol. This memorandum was reviewed by two peer 

reviewers of the DESAC (and the entire DESAC on 10/02/2014), per DESAC Standard Operating 

Procedures (SOP) 2012.J. 

Acute Dietary Exposure Assessment 

The acute dietary (drinking water only) exposure analysis and risk assessment is considered 

conservative and is based on model-derived estimated drinking water concentrations (EDWCs) for all 

direct and indirect water sources provided by the Environmental Fate and Effects Division (EFED). 

It was conducted for the general U.S. population and all population subgroups except females 13-49 

years old since no attributable effect was identified for this subgroup. The acute risk estimate for 

hymexazol was found to be well below the Agency's level of concern (LOC) for the general U.S. 

population and all population subgroup (i.e., < I 00% of the acute reference dose (aRID)). For the 

general U.S. population and all population subgroups exposure was < I% of the aRtD at the 95111 

percentile. 

Chronic Dietary Exposure Assessment 

The chronic dietary (drinking water only) exposure analysis and risk assessment is also considered 

conservative and is based on model-derived EDWCs for all direct and indirect water sources provided 

by EFED. It was conducted for the general U.S. population and all population subgroups since a 

chronic toxicological endpoint was identified for risk assessment. The chronic dietary risk estimates 

for hymexazol are below the Agency's level of concern for the general U.S. population and all 

population subgroups. For the general U.S. population and all population subgroups exposure was 

<1% of the chronic reference dose (cRtD). 

Cancer Dietary Exposure Assessment 

A cancer dietary exposure and risk assessment was not conducted since hymexazol is not likely to be 

carcinogenic to humans. 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and 

chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the 

dose that HED has concluded will result in no unreasonable adverse health effects). This dose is 

referred to as the reference dose (RID). The RID is equivalent to the point of departure (POD), no 

observed adverse effect level (NOAEL), and lowest observed adverse effect level (LOAEL) divided 

by the required uncertainty or safety factors. 

For acute and non-cancer chronic exposures, the Health Effects Division (HED) is concerned when 

estimated dietary risk exceeds I 00% of the RID. References that discuss the acute and chronic risk 

assessments in more detail are available on the EPA/pesticides web site: "Available Information on 

Assessing Exposure from Pesticides, A User's Guide," 2 l-JUN-2000, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-I 2/606 J .pdf; or see SOP 99.6 (20-AUG1999). 

This is the first dietary exposure analysis performed with the DEEM-FCID program to evaluate 

drinking water exposures for hymexazol. 

Page 2of1 1 
Hymexazol Dietary Exposure and Risk Assessment DP No. D429383 

II. Residue Information 

Tolerances: Hymexazol is a fungicide active ingredient used as a seed treatment for sugar beet seeds. 

It was concluded to be a non-food-use chemical based upon plant metabolism data which showed it to 

be metabolized to carbon dioxide and incorporated into sugars (D200191 , J. Morales, 04/04/1994). 

As such, there are no food or feed uses that require the establishment of tolerances. Hymexazol is not 

subject to the Food Quality Protection Act (FQPA) and a food dietary assessment is not required. 

However, there is potential for hymexazol to reach drinking water sources through its application to 

sugar beet seeds which does require a drinking water assessment to be performed. 

Residues of Concern: There are no uses for hymexazol which require residues of concern to be 

established for tolerance enforcement and risk assessment on food/feed crops and/or livestock. 

Dietary exposure may occur through drinking water. Because there are no degradates of exposure 

concern and no new fate data have been received, the Risk Assessment Branch (RAB) V N II risk 

assessment team has concluded that parent hymexazol only is the residue included in risk assessment 

for drinking water (D425247, M. Lloyd, 12/03/2015). 

Fish: To determine whether or not residues are present in fish, HED now routine ly checks United 

States Department of Agriculture (USDA) Pesticide Data Program (PDP) monitoring data regardless 

of the pesticide's uses and physicochemical properties. For this assessment, a search of the USDA 

PDP database found that there were no samples of catfish analyzed for the residues of hymexazol 

from 2008 through 2010. As a result, residues in fish were not included in this dietary exposure and 

risk assessment. 

Ill. Percent Crop Treated Information 

Percent crop treated information are not relevant for analysis because a food dietary assessment is not 

required for hymexazol. 

IV. Drinking Water Data 

For risk assessment, drinking water exposure is considered since hymexazol is used outdoors as a 

seed treatment for sugar beets. The EDWCs used for dietary analyses were provided by EFED in the 

memorandum "Hymexazol: Drinking Water Assessment for Registration Review" (D428894, J. 

Wolf, 09/02/2015). This drinking water assessment made by EFED was conducted for parent 

hymexazol only since there are no degradates of exposure concern. The resulting EDWCs 

determined for hymexazol were subsequently incorporated into the DEEM-FCID program for 

analysis in the food categories "water, direct, all sources" and '·water, indirect, all sources.'' 

To estimate EDWCs, models including the Surface Water Concentration Calculator (SWCC) for 

surface water and PRZM-GW for groundwater were used. The assessment was based on the 

maximum seeding rate for sugar beets which results in application rates of 0. 126 to 1.25 lb ai/ A. The 

method of hymexazol chemical application is by seeding with incorporation or drilling which is 

assumed to be 7-days before crop emergence with zero spray drift since the pesticide is applied 

directly to the seed. Because there is no leeching study available, the EFED analyses assume that 

100% of the hymexazol product applied to the seed will be available for leeching and runoff. 

For hymexazol, EFED modeling found groundwater exposure concentrations to be higher than 

Page 3 of 11 
Hymexazol Dietary Exposure and Risk Assessment DP No. 0429383 

surface water estimates. Based upon groundwater modeling analysis using the Wisconsin central 

sands scenario, the recommended EDWCs for risk assessment were calculated to be 66.6 ppb for the 

peak, and 54.5 ppb for the chronic exposure. These models and their descriptions are available at the 

EPA internet site: http://www.epa.gov/oppefed I /models/water/. 

The recommended EDWCs for hymexazol calculated by EFED for risk assessment are summarized 

below in Table 1 . 

Table 1. Estimated Drink.inf Water Concentrations (EDWCs) for Hymexazol. 

Drinking Water Source Scenario Acute Chronic Cancer 

I Model I lannlication r ate( 

Surface Water (SWCC)" MN Sugar Beets I-in-I 0 yr 30-yr 

[ 1.25 lb a. i./ A] Avg. 

μg/L 

32.80 7.69 2.67 

Groundwater (PRZM-GW) WI Central Sands Highest daily Cone. Post breakthrough Avg 

f 1.25 lb a.i./A] 66.6 54.S 

• PCA was not applied since groundwater 1s greater than surface water. 

V. DEEM-FCID Program and Consumption Information 

The hymexazol acute and chronic dietary exposure and risk assessments were conducted using the 

DEEM-FCIDTM, Version 3.16. This software uses 2003-2008 food consumption data from the 

USDA's NHANES/WWEIA. These data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods "as consumed" (e.g., apple pie) are linked 

to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat 

flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly 

by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the 

entire U.S. population and within population subgroups, but for acute exposure assessment are 

retained as individual consumption events. Based on analysis of the 2003-2008 WWEIA 

consumption data, which took into account dietary patterns and survey respondents, HED concluded 

that it is most appropriate to report risk for the fo llowing population subgroups: the general U.S. 

population, all infants (< I year old), children 1-2, children 3-5, children 6-1 2, youth 13-19, adults 20-

49, females 13-49, and adults 50-99 years old. 

For a chronic dietary exposure assessment, an estimate of the residue level in each food or food-form 

(e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily 

consumption estimate for that food/food form to produce a residue intake estimate. The resulting 

residue intake estimate for each food/food form is summed with the residue intake estimates for all 

other food/food forms on the commodity residue list to arrive at the total average estimated exposure. 

Exposure is expressed in mg/kg body weight/day and as a percent of the cRfD. This procedure is 

performed for each population subgroup. 

for acute exposure assessments, individual one-day water consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or "matched" in multiple random pairings with residue values and 

then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a 

percentage of the aRfD on both a user (i.e., only those who reported eating relevant 

commodities/food forms) and a per-capita (i.e., those who reported eating the relevant commodities 

Page 4of 11 
Hymcxazol Dietary Exposure and Risk Assessment DP No. D429383 

as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are 

reported for all tiers of analysis. However, for tiers l and 2, any significant differences in user vs. per 

capita exposure and risk are specifically identified and noted in the risk assessment. 

VI. Toxicological Information 

The RAB V N II toxicologists have reevaluated the hymexazol database and updated the endpoints as 

necessary. Following HED ToxSAC review, the acute and chronic toxicological endpoints selected 

for the human health risk assessment of hymexazol are summarized below in Table 2. 

Table2. Summary of Toxicological Doses a nd Endpoints fo r Hymexazol for Use in Dietary Exposure Risk 

Assessment. 

Exposure/ Point of Uncertainty/FQP RID, PAD, Level 

Scena rio Departure A Safety Factors of Concern Study and Toxicoloe.ical Effects 

Acute Dietary NOAEL = UFA = I Ox aRID = 1.5 Developmental Study - Rabbit 

(General Population) ISO UFll = I Ox mg/kg/day 

mg/kg/day Maternal LOAEL = 450 mg/kg/day based 

on mortality. abnormal clinical signs 

(unsteadiness. slumped posture. increased 

respiration. and salivation) within an hour 

of dosing, and decreased food 

consumption and body weight loss within 

2 days of initial exposure. 

Acute Dietary An acute RID specific to Females 13-49 was not calculated because no effect attributable to a 

(Females 13-49) single day oral exposure that would be specific to this population subgroup was observed in the 

toxicity database including the developmental and reproduction studies. 

Chronic Dietary (all NOAEL = UFA = I Ox cRID = 0.31 2-Gencration Reproduction Study -

populations) 31 UFH = I Ox mg/kg/day Rat 

mg/kg/day 

Offspring LOA EL = I 59 mg/kg based on 

increase in post-implantation loss. 

decrease in li1ter size. 

Cancer (oral, dermal. Classification: "'Not Likely to be Carcinogenic to Humans·· inhalation) 

Pomt of Departure (POD) = A data pomt or an estimated pomt that 1s derived from observed dose-response data and used to mark the 

beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. OAEL = no observed 

adverse effect level. LOA EL= lowest observed adverse effect level. UF = uncertainty factor. UFA = extrapolation from animal to 

human (interspecies). UFu = potential variation in sensitivity among members of the human population (intraspecies). SF = Safety 

Factor. (c = chronic). RID = reference dose. 

VII. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when the dietary risk estimate 

exceeds I 00% of the RID. Acute and chronic analyses were perfonned for hymexazol using DEEMFCID (ver. 3. 16) estimating the dietary (drinking water only) exposure of the U.S. population and 

various population subgroups. The results are summarized in Table 3. The resulting acute drinking 

water exposure estimates were less than HED's level of concern (<I 00% aRfD) for the general U.S. 

population and all population sub-groups at the 95th percentile. The resulting chronic drinking water 

exposure estimates were less than HED's level of concern (<100% cRfD) for the general U.S. 

population and all population sub-groups. 

Page 5of 11 
Hymexazol Dietary Exposure and Risk Assessment DP No. D429383 

Table 3. Summa ry of Dietary ffirinkine Wa ter) Exposur e a nd Risk for the H vmexazol. 

Acute Dietary1 

Chronic Dietary2 

(95lh Percentile) 

Population Subgroup 

Dietary Exposure %aRfD Dietary Exposure 

(mg/kg/day) (mg/kg/day) 

.General U.S. Population 0.00363 1 < l 0.001141 

All Infants(< I year old) 0.01 1374 <I 0.002943 

Children 1-2 years old 0.005600 < l 0.001646 

Children 3-5 years old 0.004544 < l 0.001387 

Children 6- 12 years old 0.003472 < I 0.00 1000 

Youth 13- 19 years old 0.003024 < I 0.000832 

Adults 20-49 years old 0.003574 < I 0.001 139 

Adults 50-99 years old 0.003183 < l 0.001126 

Females 13-49 years old NA4 NA 0.001134 

1 Acuie dietary analysis derived from a 1.5 mg/kg/day aRfD for lhe general population. 2 Chronic dietary analysis derived from a 0.31 mg/kg/day cRfD for 1he general populaiion. 3 1-l ighesl exposures found for each assessment arc noted in bold. 4 A - ·· 01 assessed .. because no attributable efTect was identified 

VJII. Cha racterization of Inputs/Outputs 

%cRfD 

< l 

< l 

< l 

< ) 

< I 

< I 

< I 

< I 

< l 

The acute and chronic di etary assessments of drinking water made with DEEM-FCID for hymexazol 

are unrefined analyses. They utilize conservative EDWCs derived using the new or updated EFED 

SWCC and PRZM-GW models which estimate the concentration of hymexazol in drinking water 

based upon sugar beet seed treatment application at the maximum seeding rate. It uses no 

refinements assuming it is present in drinking water at these anticipated concentrations. The resulting 

dietary exposure estimates determined with DEEM-FCID assumes that all drinking water will contain 

hymexazol at the EDWCs modeled by EFED. For these reasons, it can be concluded that the DEEMFCID analyses do not underestimate risk from exposure to hymexazol for the general U.S. population 

and all population subgroups. 

IX. Conclusions 

Acute and chronic dietary assessments of drinking water were conducted for the fungicide hymexazol 

which is used for treating sugar beet seeds. All dietary analyses were performed using EDWCs 

calculated by EFED using current SWCC and PRZM-GW models. Groundwater exposure 

concentrations were found to be higher than surface water estimates and thus were recommended 

used for risk assessment. The estimated acute exposure to hymexazol in drinking water resulted in an 

estimated risk which was< 1 % of the aRtD for the general U.S. population and all population 

subgroups at the 95111 percentile which is well below the Agency's level of concern. The estimated 

chronic exposure to hymexazol in dri nking water are also not of concern with all results being <1 % of 

the cRID for the general U.S. population and all population subgroups. Because this dietary 

assessment is made using conservative assumptions such as model-derived EDWCs it is not likely to 

underestimate risk. 

Page 6 of 11 
Hymexazol Dietary Exposure and Risk Assessment DP No. 0429383 

References 

DP No.: D200191 

Subject: 048210-R. Hymexazol in/on Sugar Beet Seeds. Determination of Food/Non-Food 

Use. CBTS# 13,341. DP Barcode D200191. MRlD# 428263-14. 

From: 

To: 

Dated: 

MRIDNo.: 

DP No.: 

Subject: 

From: 

To: 

Dated : 

MRlD No.: 

DP No.: 

Subject: 

From: 

To: 

Dated: 

MRlD No.: 

J. Morales 

B. Chambliss and A. Kocialski 

0410411994 

428263-14 

D425247 

Hymexazol. Human Health Risk Assessment of the Fungicide Hymexazol for 

Registration Review. 

M. Lloyd 

R. Jones 

12/03/2015 

None 

D428894 

Hymexazol: Drinking Water Assessment for Registration Review. 

J. Wolf 

R. Jones, P. Savoia, M. Lloyd, and M. Metzger 

09/02/201 5 

None 

X. List of Attachments 

1. Attachment 1: Acute Dietary Input File (Drinking Water only). 

2. Attachment 2: Chronic Dietary Input File (Drinking Water only). 

3. Attachment 3: Acute Dietary Results (Drinking Water only) File. 

4. Attachment 4: Chronic Dietary Results (Drinking Water only) File. 

Page 7of 11 
Hymexazol Dietary Exposure and Risk Assessment DP No. 0429383 

Attachment 1 

Acute Dietary Input File (Drinking Water only) 

Filename: E : \Hymexazol\1 29107 Hymexazol_Acute_Input File_Reg Rev Sept 2015_Water only . r08 

Chemical: 129107 Hymexazol 

RfD (Chronic) : .31 mg /kg bw/day NOEL (Chronic) : 31 mg/kg bw/ day 

RfD(Acute): 1.5 mg/kg bw/day NOEL(Acute) : 150 mg/kg bw/day 

Date created/last modified: 10-01- 2015 /14:39:06 Program ver. 3.16, 03-08-d 

Comment: 129107 Hymexazol Reg Rev Aug 2015 Drinking Water only 

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment 

Code Grp Commodity Name (ppm) Ill #2 

-----··--- ------------- ---- -------------- ---------- ------- 8601000000 86A Water, direct, all sources 0.066600 1.000 1.000 

8602000000 86B Water, indirect, all sources 0 . 066600 1 . 000 1.000 

Page 8 of 11 
Hymexazol Dietary Exposure and Risk Assessment DP No. D429383 

Attachment 2 

Chronic Dietary Input File (Drinking Water only) 

Filename : E : \Hymexazol\129107 Hymexazol_Chronic_ Input File_Reg Rev Sept 2015 Water only.roa 

Chemical: 129107 Hyme.xazol 

RfD(ChronicJ: .31 mg/kg bw/day NOEL(Chronic) : 31 mg/kg bw/day 

RfD(AcuteJ: 1.5 mg / kg bw/ day NOEL(Acute ) : 150 mg/kg bw/ day 

Date created/last modified : 10 - 01-2015/14:38:47 Program ver. 3.16, 03-08-d 

Comment : 129107 Hymexazol Reg Rev Aug 2015 Dr inki ng Wa ter only 

EPA Crop Def Res Adj.Factor s Comment 

Code Grp Commodity Name (ppm) Ill 112 

--·------- ------------------------------- -------·-- ------- 8601000000 86A water, direct, all sources 0 . 054500 1.000 1.000 

8602000000 868 Water, indirect, all sources 0 . 054500 l.000 1.000 

Page 9of11 
Hymexazol Dietary Exposure and Risk Assessment 

Attachment 3 

Acute Dietary Results (Drinking Water only) 

US EPA 

DEEM-FCID ACUTE Analysis for 129107 HYMEXAZOL 

Residue file: 129107 Hymexazol_Acute_ I nput File_ Reg 

Adjustment factor #2 NOT used. 

Ver. 3.18, 03-08-d 

NHANES 2003-2008 2-Day 

Rev Sept 2015_Wa ter only . r08 

Analysis Date: 10-01- 2015/14:48:00 Residue file dated: 10-01-2015 /14 :39:06 

NOEL (Acute) = 150.000000 mg/kg body- wt/day 

RAC/FF intake summed over 24 hours 

Run Comment: "129107 Hymexazol Reg Rev Aug 2015 Drinking Wa ter only" 

=================2a===== == ===================================================== 

Summary calculations--per capita: 

95th Percentile-- - - 99th Percentile---- - -- 99.9th Percentile----

Exposure t aRfD MOE Exposure t aRfD MOE Exposure t aRfD MOE 

---------- - ------ -------- --------.. - -·-·--- ... -.. -........ - ---------- ---- --- -------- Total us Population: 

0.003631 0 .24 41305 0.005988 0 . 40 25048 0.011376 0 . 76 13185 

All Infants: 

0.011374 0.76 13187 0.015407 1.03 9736 0.022580 1. 51 6642 

Children 1-2: 

0.005600 0.37 26786 0.008432 0 . 56 17788 0.020766 1.38 7223 

Children 3-5: 

0 . 004544 0 .30 33011 0.006959 0 .4 6 21554 0 .011170 0.74 13428 

Children 6-12: 

0.003472 0 .23 43204 0.005698 0 . 38 26325 0.008782 0.59 17080 

Youth 13-19: 

0.003024 0 . 20 49597 0.004981 0 . 33 30113 0 . 007521 0.50 19944 

Adults 20- 49: 

0.003574 0 .24 41974 0.005318 0 . 35 28205 0.007737 0 . 52 19387 

Adults 50-99 : 

0 . 003183 0 . 21 47120 0.004 827 0.32 31076 0.007608 0 .51 19714 

Female 13-49: 

0.003625 0.24 41384 0.005330 0 . 36 28143 0.007475 0.50 20067 

Page 10 of 11 

DP No. D429383 
Hymexazol Dietary Exposure and Risk Assessment DP No. D429383 

Attachment 4 

Chronic Dietary Results (Drinking Water only) 

US EPA Ver. 3.16, 03-08-d 

DEEM-FCID Chronic analysis for 129107 HYMEXAZOL NHANES 2003-2008 2-day 

Residue file name : E:\Hymexazol\1291 07 Hymexazol_Chronic_Input File_Reg Rev Sept 2015_Water only.r08 

Adjustment factor tt2 used. 

Analysis Date 10-01-2015/14:50:17 Residue file dated: 10-01-2015/14:38 : 47 

Reference dose (RfD, Chronic) = .31 mg/kg bw/day 

COMMENT l: 129107 Hymexazol Reg Rev Aug 2015 Drinking Water only 

=== ·==== =============== == ~= === ========= ====== ================ =============== 

Tota l exposure by population subg roup 

-------------- --------------------- ------------------------------------------ --

Population 

Subgroup 

Total us Population 

Hispanic 

Non-Hisp-White 

Non-Hisp-Black 

Non- Hisp-Other 

Nursing Infants 

Non-Nursing Infants 

Female 13+ PREG 

Children 1-6 

Children 7-12 

Male 13-19 

Female 13-19/NP 

Male 20+ 

Female 20+/NP 

Seniors 55+ 

All Infants 

Female 13 - SO 

Children 1-2 

Children 3-5 

Children 6-12 

Youth 13-19 

Adults 20-49 

Adults 50-99 

Female 13-49 

Total Exposure 

mg/kg 

body wt/day 

0.001141 

0 . 001090 

0 . 001174 

0.000942 

0 . 001315 

0.001032 

0.003796 

0 . 001075 

0.001462 

0.000951 

0 . 000784 

0.000879 

0.001063 

0 . 001199 

0 .001103 

0.002943 

0 . 001136 

0.001646 

0.001387 

0 . 001000 

0.000832 

0. 001139 

0.001126 

0 . 001134 

Percent of 

Rf d 

0.4\ 

0 .4\ 

0.4\ 

0. 3t 

0 .4\ 

0 .3\ 

l. 2t 

0. 3t 

0.5t 

0.3t 

0 .3\ 

0.3\ 

0. 3t 

0 .4\ 

0.4\-

0.9\-

0.4t 

0.St 

0.4\-

0 .)t 

0.3\-

0.4\-

0 .4\-

0.4t 

-------- ------------------ ---------------------- --------------------- --- -------

Page 11 of 11