UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON , D .C. 20460

Dat e: Dec e mber 03 , 2015 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION

SUBJECT : Hymexazol. Acute and Chronic Di e tary Exposure and Risk Assessments of Drinking Water to Suppo rt Registration Review. P C Code: 129107 DP Barc o d e : 0429383 D ecis ion No.: 49934 I Reg i s tr a ti o n No.: 482 I 0- I Pet i tio n No.: NA Re gu latory Act ion: Regi s tration Review Risk Asse ss m e nt T y pe: Single Chemical , Dietary Case No.: 7016 TXR No.: NA CAS No.: 10004-44-1 MRID No.: None 40 C FR : NA
FR OM: P eter Savoia , Chemis t 

# a...-fl{__- h**~** Risk Assessment Branch 

### V
T HR U : Health Effects Di vision (7509 P ) Dan ette Drew , Chemist , and /, 

# j

# J u; j /) 

# j Michael S. Metzger , Bran ch

# chi~ 

# vvtftv--'l ' Risk Assessment Branch V Health Effects Divi sion (7509P) And I 

## i-rWilliam C utchin ,**hemist ,~** **/~** • vv&,, L- "\A..c**~** Kristin Rury , Biol ogist**~** Dietary Exposure Science Advis ouncil Health Effects Di v i sio n ( 7509P ) TO: Matthew Lloyd , Risk Assessor Ri sk Assessment B ranch V/ VII Hea lth Effect s Di vision (7509 P ) And Ricardo J ones , Chemical R eview Manager Ri sk Management and Impl e m e ntati o n Branch I Pe st icide Re- Eva luation Division (7508P)
Exec utive Summary Acute and chronic dietary exposure and ri s k assessments of drinking water only for the fungicide hymexazol were conducted using the Di e tary Ex po s ure Ev aluation M ode l software with the Food Commodi ty In take Dat abase ( DEEM-FCID) Version 3.16. This software uses 2003-2008 food consu mption data from the U
. S. Departm e nt of Agriculture ' s (US DA ' s) National H ea lth and Nutr ition Examination Survey/What We Eat in America , (NHANES / WWE IA)
. These analyses reflec t the late st consumption data for the evaluat ion of dietary expos ure made to su pport the P age I of 11Hymexazol Dietary Exposure and Risk Assessment DP No. 0429383
registration review risk assessment of hymexazol. This m emorandum was reviewed by two peer reviewers of the D ESAC (and the entire DE SAC on 10 / 02 / 2014), per DESAC Standard Operatin g Procedures (SO P ) 20 1 2.J. Acute Dietary Exposure Assessment The acute dietary (dr inkin g water only) exposure analys i s and risk assessmen t is considered conse r vat i ve and i s based o n m odel -d e rived est im a ted drinkin g wate r co nc e ntra ti ons (E DWC s) for all direct and indirect water sources provided by the E nvironmental Fate and Effects Division (EFE D ). It was conducted fo r the genera l U.S. popu la tion and all popu lation s ub groups except fema les 1 3 -49 years o ld s in ce no attributable effect was identified for this subgroup. Th e acute ri s k estimate for hymexazol was found to be well below the Agency ' s level of co nc ern (LOC) for the general U.S
. population a nd all p o pul at ion subgroup ( i .e., < I 00% of the acute reference dose (aRID)). For the general U.S. population a nd all population subgroups exposure was < I% of the aRtD at the 95 111 percentile. Chronic Dietary Ex posure Assessment The chronic dietary (drinking water only) exposure analy s is and risk assessment is a l so co n sidered co n servat i ve and is based on model-derived EDW Cs for a ll direct and indirect water so urc es provided by EFE D. It was co ndu cted for the genera l U.S
. population and all population s u bgroups since a chronic toxicological endpoint was identified for risk assessment. The chronic dietary risk estimates fo r h ymexazo l are below the Agency's le ve l of concern for the general U
. S. population and all population s ubgroups. For the general U.S. population and all population subgroups exposure was < 1% of the c hroni c reference dose (cRtD). Cancer Di eta r y Expos ur e Assess m e nt A cancer dietary exposure and risk assessment was not conducted since h ymexazol is not likel y to be carcinogenic to humans. 

### I. Introduction Dietary risk assessment incorporates both exposure and toxicity of a give n pesticide. For acute and c hroni c assessments , the ri sk is expressed as a percentage of a maximum acceptable dose (i.e., the dose that HED has concluded wi ll re s ult in no unreasonable adverse health effec t s)
. Thi s dose i s referred to as the refe ren ce d ose (RID). Th e RID i s equivalent to the point of departure (POD) , no observed adverse effect level (N OAEL) , and lo wes t observed adverse e ffect level (LOAE L) divided by the re quired un certai nty or safe ty factors. For acute and non- canc er c hronic exposures , the H ea lth E ffects Divi sio n ( H E D) i s co ncerned when estimated dietary risk exceeds I 00% of the RID. Refe re nces that discuss the acute and chron ic risk assessme n ts in more detail are avai labl e on the EPA/pesticides web s ite : "Ava ilabl e Information o n Assessing Exposure from Pe sticides, A User 's Guide ," 2 l-J UN-2000 , web link: http: // www.epa.gov/ fedrgstr/EPA -P EST/2000/ July/ Day- I 2/ 606 J .pdf; or see SO P 99.6 (20

- AUG

1999 ). 

### This i s the fi rst di e tary exposur e analysis performed with the DEEM-FCID program to evaluate drinking water exposures for h ymexazo l.

P age 2of1 1Hymexazol Dietary Expos ure a nd Ri sk Asse ss ment DP No. D429383 

### II. R es idu e In fo rm a ti on Tolerances: Hymexazol is a fung icid e active ingredi e nt u sed as a seed treatment fo r s u gar beet seeds
. It was concluded to b e a non-food-use c hemi ca l ba sed upon plant m e t abo li s m d ata w hich s ho wed it to be metabolized to carbon dioxide and incorporated into sugars ( D200191 , J. Morales, 04 /04/ 1 994). As s uch , there are no food or feed u ses that require the establishment of tol e rance s . H y m exazo l i s not subject to the F ood Quality P ro tec tion Ac t (FQPA) and a food dietary assess ment i s n ot required. However, there i s potential fo r hymexazo l to r ea ch drinkin g wate r so urces throu g h i ts app li catio n to sugar beet see d s which do es req uire a drink i n g w ater assess m e nt to be p e rfo rm e d. 

### R es idues of Concern: T he re a r e no uses for hy me xazo l which require re s idu es of co ncern to be es t abli s hed for toleranc e e nfor ce men t a nd ri sk assess m e nt o n food/feed cro p s and/or li vestock
. Di e tary expos ure may occur through d rinkin g water. Becau se there are n o degradates of ex po sure co n ce rn a nd n o n ew fate data have b ee n rec e ived , th e R i sk Assessment Bran c h (RAB) V 

### N II ri s k assessment team has conclu d ed that parent h y mexazo l o nl y i s the re s idue in cluded in ri sk assessme nt fo r drinking wa te r ( D 42524 7 , 

### M. Ll oy d , 1 2/ 03 / 20 1 5). 

### Fish: To determ in e whether or not re s idues are present in fi s h , HED now rou tin e l y checks United S tates D e partm e nt of Agriculture (US DA ) Pes ti c id e Data P rogram ( PDP ) monitorin g data re ga rd less of the pesticide 's uses and ph ys icochemical p rop ertie s. For this assessment , a search of the US D A PDP database fo und that there we re no sa mpl es of catfish an a lyzed fo r th e residue s of h y m exazo l from 2008 throug h 2010. As a r es ult , residues in fi s h we re not in c lud e d in thi s dietary expos ure and ri s k assessment. 

### I ll
. P erce nt Cro p Treate d In fo r m a tio n P e rcent cro p treated in fo rmati o n are n o t rel evant for analysi s becau se a food dietary assessment i s not requi red fo r h ymexazo l. 

### I V. Drinkin g W a t er Data For ri sk assess m e nt , drinking wate r expos ur e i s con s id e re d s in ce hymexazol is used outdoors as a see d trea tm ent fo r sugar beets. The EDWCs u sed for dietary analyses were provid e d by E F ED in the m e morandum " H y me xazo l: Drinkin g Water Assessment for Reg i strat ion R ev i ew " ( D4 28 894 , J. Wo lf , 09 / 02 /2015). Thi s dr inkin g water asse ss ment made b y E FED was conducted for parent hy mexazol o nl y s ince th e re are no d eg rada t es of expos ure co n ce rn. The resu ltin g E DW Cs d ete rmine d for hy m exazo l were su b seq u e ntl y inc o rp orated into th e D EEM-FC ID program for analysis in the food categories " water , direct , a ll sources " and ' ·wate r , indirect , all so urce s.' ' To estimate EDWCs , models includin g the Su rface Water Concen tration Calcu lator (S W CC) for s urface wate r and P RZM-GW fo r gro undw ater were used. T he assessment was based o n the m ax imum see din g rate fo r s u gar be e t s which res ult s in a ppli cation rates of 0. 12 6 to 1 .25 lb ai/ A. T h e m ethod of hymexazol chemi cal app li cation i s by seeding wi th incorporation or drillin g wh ich i s ass um ed to b e 7-days b efo re crop emergence with zero s pray drift s ince th e pesticide is app l ied directly to the seed. B ecau se th e re i s no lee ching study avai lable , th e EFED ana l yses assume that 100% of the hy mexazol produ c t app li ed to th e seed w ill be ava ilab le fo r leec hin g and runoff. For hymexazol , EFED modelin g found g roundwater ex posure concentrat ions to be higher than P age 

### 3 of 11Hymexazol Dietary Exposu re and Risk Assessment DP No. 0429383
su rfa ce water estimates. Based upon groundwater modeling analysis u s ing the Wisconsin ce ntral sands scenario, the reco mm ended EDWCs for risk assessment were calculated to be 66.6 ppb for the peak, and 54.5 ppb for the chron ic exposure. These models and thei r desc riptions are available at the EPA internet s ite: http: //www.epa.gov / oppefed I/ models/ water /
. The recommended E DWCs for hym exazo l calcu lated by EFED for risk assessment are summar i zed below in Table 1 .

Tab le 1. Estimated Drink.inf W a ter Co n centrations (E DWC s) for H y me xazo l
. Drinking Water So u rce Sce na ri o Acute Chro n ic Ca n cer 

### IModel 

### I lann li cation r a te( Surface Water (SWCC)" MN Sugar B eets I-in-I 0 yr 30-yr [ 1.25 lb a. i. / A] Avg. μ g/L 32.80 7.69 2.67 Groundwater ( PRZM-GW) WI Central Sands Highest daily Cone. Post breakthrough Avg 

### f 1.25 lb a. i./ A] 66.6 54.S • PCA was not applied s ince groundwater 1 s gr eater than surface water . 

### V. DEEM-FCID Program and Consumption Inform a tion The hymexazol acute and chronic dietary exposure and risk assessments were conducted u si ng the DEEM-FC ID TM , Version 3.16. This software uses 2003-2008 food consumption data from the US DA ' s N H ANES / WWE I A. These d ata are based o n the reported consumption of more than 20,000 individuals over two non-consecutive survey day s. F oods " as consumed" (e.g. , app le pie) are linked to EPA -defin ed food commodities (e.g. apples, peeled fruit

- cooked; fresh or N / S; baked; or wheat flour

- cooked; fresh or N / S , baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment , consumption data are averaged for the entire U.S. population and with in population subgroups, but for ac ute exposure assessment are retained as individual consumption events. Based on analysis of the 2003

- 2008 WWEIA co n sumption data , which took into account dietary patterns and survey respondents, HED concluded that it is mo s t appropriate to report ri sk for the fo ll owi ng population s ub g roup s: the general U.S. populat ion, all infant s ( < I year old) , c h ildren 1-2, chi ldre n 3-5, chi l dren 6 -1 2, youth 13-19 , ad ul ts 20

- 49 , females 13-49 , and ad ult s 50-99 years old
. For a chro n ic dietary exposure assessment, an estimate of the residue le ve l in each food or food-form (e.g. , orange or orange juice) on the food commodity r es idu e li s t is multipli e d by th e average daily consu mption esti mat e for that food/food form to produce a residue intake estimate
. Th e re su lting residue intake estimate for each food/food form is summed with the residue intake estimates for all othe r food/food forms on the commodity re sid ue li st to arrive at the total average estimated expos ure . Exposure is expressed in mg/kg body weight/day and as a perce nt of the cRfD
. Thi s procedure is pe rformed for each population subgroup. for acute exposure assess m e nts , ind iv i d u al one-day water consumption data are us ed on an individual

- by-individual basis. The reported consumption amounts of eac h food i tem can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deter mini st ic expos ure assessment, or "ma tched " in multiple random pairings with residue va lu es and then summed in a probabili s t ic assessment. The re s ulting d i stribution of exposures is ex pre ssed as a percentage of the aRfD o n both a use r (i.e., only those who r eported eating relevant commodit ies/ food forms) and a per-capita (i.e
. , those who reported eating the relevant commodities Pa ge 4of 11Hymcxazol Dietary Exposu re and Risk Assessment DP No. D429383


### as we ll as those w h o did not ) ba s is. In acco rd ance wit h HED policy , p e r capita expos ure and ri sk are r e port e d for a ll tiers of analysis. Ho weve r , fo r tiers l and 2, any s ign ificant differences in user vs . per capita exposure and ri sk are spec ific a ll y identifi e d and noted in the risk assessment. 

### VI. Toxico l og i ca l I n fo r m at i o n Th e RAB VN II toxicologists have reevaluat e d the hy m exazo l database and updated th e endpoints as necessary. Following H E D ToxSAC review , the acute and chro ni c to xico log i cal e ndp o int s se l ec ted fo r the human h ealth risk assessment of hymexa zo l are summ arized below in Tabl e 2. Table2. S u m m ary o f Tox i co logica l D o se s a nd E n d p o in ts fo r H y mexazo l fo r Use in Di eta r y Ex p os ur e Ri s k Assess m e n t. Ex p os ure/ P o int o f Un certa in ty/ FQP RID , PAD , Leve l Sce n a ri o De p art ur e A Sa f ety Fact o r s of Co n ce rn St ud y a nd Tox ico l oe.ica l E ff ects Acute Di etary NOAEL = UFA = I Ox aRID = 1.5 D eve l opmenta l Stud y - Rabbit (General Population) IS O UFll = IOx mg/kg/day mg/k g/ da y Maternal LOAEL = 450 mg/kg/day based o n mortality. abnorma l clinical signs (un s teadines s . slumped posture. increased re spiration. and salivation) within an hour of dosing, and decreased food consumption and body weight lo ss within 2 days of initi al exposure. Acute Dietar y An acute RID spec ific to Female s 13-49 was not calculated because no effect attributable to a (Females 13-49) s ingl e day oral expos ure that would be s p ecific to thi s population s ubgro up was observed in the toxicity database including the developmental and reproduction studies. Chronic Dietary (a ll NOAEL = UFA = IOx cRID = 0
. 31 2-Gen c r atio n Reproduction Study

- populations) 31 UF H = IOx m g/kg/day Rat m

g/

k

g/

da y Off s pring LOA EL = I 59 mg/kg based on increase in post
- implantation loss. decrease in li1ter s ize . Cancer ( oral, dermal. Cla s sificat ion : "' Not L i ke l y to be C arc in ogenic to Human s·· inhal ation) Pomt of Departure (POD) = A data pomt or an estimated pomt that 1s derived from observed do se -respon se dat a and used to mark the beginning of extrapolation to determine ri s k associated with lower environmentally relevant human expo s ures . OAEL = no observed adverse effect level. LOA EL = lowe st ob served adverse effec t l evel. UF = uncertaint y factor. UFA= extrapo lat ion from animal to human ( interspecies ). UFu = potential variation in sensitivit y among members of the human population (intraspecie s). SF = Safety Factor
. (c = chronic). RID = ref eren ce dose. 

### VI I. Res ul ts/D isc u ss i o n As stated above , for acute and c hronic assess me nt s, HE D is conce rn e d w he n th e di etary ri sk est im ate ex ceeds I 00 % of the RID. Acute and chronic analy ses were perfonn ed for hy mexazo l using DEEMFC ID (ver. 3. 1 6) estimat ing the dietary ( drinkin g wate r on ly) ex p osure of t he U .S. popu lati o n and variou s population su b g roup s . T he res ult s are su mmari ze d in T a bl e 3. T he resultin g acu te drinking water exposure estim ates we re less than HED 's lev e l of co n ce rn (<I 00 % aRfD) for the ge ne ra l U
. S. populati o n and all popu lation s ub- gro up s at the 95th percentile. The re su lt in g c hroni c drinking wa t er ex p os ure estimates we re less than H E D 's l eve l of concern ( < 100 % cRfD) for th e ge neral U.S
. population a nd a ll popul ation s ub- gro up s.

Pa ge 5of 11H ymexazo l Di e t ary Ex p os ure a nd Ri s k Assess m e nt DP No. D 429383 Tab le 3
. S umm a ry o f D ie ta ry ffirinkin e W a t e r) Ex p os u r e a nd Ri s k fo r t h e H v m exazo l
. A c ute Di e tary 1 C hr o ni c D iet ary 2 (95lh Pe rc e ntil e) Popu lati o n S ubgro up Di e t ary Ex p os ure %a RfD Di e t ary Ex p os ur e ( m g/ kg/ d ay) ( mg/kg/d ay)

. G e nera l U.S. Po pul at io n 0.00363 1 < l 0.001141 A ll I nfa nt s(< I ye ar o ld ) 0
. 01 1374 < I 0. 0029 4 3 C hil d re n 1 -2 yea r s o ld 0.005600 < l 0.001646 C hil dre n 3-5 years o ld 0.004544 < l 0.001387 C hil dre n 6- 1 2 yea r s o ld 0.003472 < I 0.00 1000 You th 1 3- 1 9 years o ld 0.003024 < I 0.000832 Ad u lts 20-49 yea r s old 0.003574 < I 0.001 1 39 Adu lt s 50-99 yea r s old 0.003183 < l 0.001126 Fe m a les 13-49 years old NA 4 NA 0.001134 1 Acu ie dietary analys i s d erived fro m a 1 .5 mg/kg/day a RfD fo r lhe genera l population. 2 Chronic dietary analysis derived from a 0.31 m g/kg/day cRfD for 1he general populaiion. 3 1-l ighes l expo s ures fou n d for eac h assessmen t arc noted in bold
. 4 A

- ·· 01 assessed
.. because no att ributable efTec t was iden tified 

### V JII. C h a r a cte riz a tion of Input s/ Outp u t s %c RfD
< l < l < l < )
< I < I < I < I < l



### T h e ac ute a nd c hr o nic di etary assess ment s of drinkin g w ater mad e with D E EM

- FC ID fo r hy mexazo l are unr e fin ed ana l yses. T hey util ize c on serv ati ve E DW Cs de rived u s in g th e new or upd ate d EF ED S W CC a n d PRZ M -GW mo de l s whi c h es tim a te th e co nc entrati o n of h ymexazo l in drinking wate r ba se d upon s u ga r beet see d treatment appl i cation at th e m ax imum se e d in g rate . It 

### uses no r e fin e ment s ass umin g it is prese nt in dr inki ng wat er at these a nticipate d con c en trati o n s . Th e re s ultin g di etary ex p os ur e e st im a t es determin e d w ith D EEM

- F CID ass um es th at a ll drinkin g wa ter will c o ntain hy mexaz ol at th e E DW Cs mod e le d by E FED
. For th ese reaso ns, i t can be co nclud ed t hat th e DEEM

FC ID a na l yses do n ot und eres timate ri s k from ex po s ure to hymex az o l for the ge ne ra l U.S
. po pul ati o n and a ll po p ul ati o n s ub g ro u ps. I X. Co nclusi o n s 

### Ac ut e a nd c hron i c die tary assess ment s of drinkin g wa t er were co ndu c t e d fo r th e fu ng ic i de hy mexazo l whi c h is u se d fo r tr eatin g s ug ar be et see d s . A ll di etary an a ly ses we re perfo rm e d us ing EDW Cs ca lc ul ate d by E F ED us in g c urr ent SW C C an d P RZM-GW mod e l s. Gro un dwa ter ex po s ure concentra tion s we re found t o be hi g her th an surface wa t e r es tim ates and thu s were r eco mme nd e d use d fo r ri s k a ssess ment. T he es tim ate d acut e expo s ure to hy me xaz ol in drinkin g w ater res ult e d in a n e s tim ate d r isk w hi c h was< 1 % 

### of th e a RtD fo r the ge neral U.S
. po pul a tion and a ll p op u lati o n s ub g roup s at th e 95 1 11 

### p erce ntil e whi c h i s we ll be low th e Age ncy's leve l of co nce rn. Th e es t i mate d c hro ni c e xp os ure to h yme xaz ol in dri nkin g wa ter are a ls o not o f c onc ern w ith a ll res ult s bein g < 1 % 

### of the c RID fo r t he ge nera l U.S
. po pulatio n and all po p ula ti o n s ubgro up s . Beca u se thi s d ie tary assess ment i s mad e u s in g co n se r va ti ve ass umpt io n s s uc h as m o de l-d e rive d ED WCs it is not li ke ly to un de r es tim ate ri s k. Page 6 

### of 11Hymexazol Dietary E xposure and Ri sk Assessment DP No. 0429383 

### R

ef

erenc es DP No.: D200191 Subject: 048210-R. Hymexazol in/on Sugar Beet Seed s. Det e rminati on of Food/No n-F ood Use. CBTS # 13 , 3 41. DP Barcode D200191. MRlD # 42826 3 -14. 

### From: To: Dated : MRIDNo.: DP No .: Subject: 

### F

rom: To: Dated : MRlD No.: DP No.: S ubj ect: From: T o: Dated: MRlD No. : J. Morales B . C hambliss and A
. Kocial s ki 04 1 04 1 1994 428263-14 D4 25247 H y mexazol. Human Hea lth Risk Assess ment of the Fungicide Hym exazo l for R egistrati o n R ev i ew. 

### M. Lloyd R. J o ne s 12/03 / 2015 None D4 2 8894 H y m exazo l: Drinkin g Water Assessment fo r R eg i s tration Review. J. W o lf R
. J o ne s, P. Savoia, M. Llo yd, and M. Metzger 09/ 02 / 201 5 None X. List of Attac hm ents 1. Attachment 1: Acute Dietary Input File ( Drinking Water o nl y)
. 2. Attac hment 2: Chronic Di e tary Input File ( Drinking Water only). 3. A ttachment 3 : Acute Di e ta r y R es ult s ( Drinkin g Water o nl y) File. 4. Attac hm e nt 4 : Chronic Di e tary R es ult s ( Drinking Water only) Fil e.

Pag e 7of 11H y m exazo l Dietary Ex pos u re a nd Ri sk Assess m ent D P No. 04 293 8 3 A tt ac hm e nt 1 Ac u te Di e tary Inpu t F il e (D rinkin g W ater o nly)
Filename: E : \Hymexazol\ 1 29107 Hymexazol

_ Acute_Input F ile

_ R eg Rev Sept 2015_Water only
. r08 Chemical: 129107 Hymexazol RfD (Ch ron ic) : .31 mg /k g bw /d ay NOEL (Chronic) : 31 mg/kg bw / day RfD(Acute): 1.5 mg/kg b w /day NOEL(Acute) : 150 mg/kg bw/day Dat e created /last modified: 10 -01- 2015 /1 4:39:06 Program ver. 3.16, 03-08- d Comment: 129107 Hymexazol Reg Rev Aug 2015 Drinking Water only



### - -- - -- - -------------------------------------------------------- - - -- ---- --------- - -- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) Ill #2



### -- ---··--- 

### - - - ---------- - - -- - - - ----------- 

### -- -- - -- -- - 

### ------- 8601000000 86A Water, direct, all sources 0.066600 1.000 1.000 86 02000000 86B Water, indirect, all sources 0
. 066600 1
. 000 1.000

Page 8 of 11H ymex azo l Dieta ry E xposure and Ri sk Asse ss m e nt D P No. D 4

2938 3 

### Attachment 2 Chronic Dietary Input File (Drinking Water only )

Filename : E : \Hymexazol\129107 Hymexazol

_ Chronic

_ Input File_Reg Rev Sept 2015 Water only.roa Chemical: 129107 Hyme.xazol RfD(ChronicJ: .31 mg/kg b w /day NO EL(Chronic) : 31 mg/kg b w /day RfD(AcuteJ: 1.5 mg / kg bw / day NOEL(Acute ) : 150 mg/kg bw / day Date created/last modified : 10

- 01-2015/14:38:47 Program ver. 3.16, 03-08-d Comment : 129107 Hymexazol Reg Rev A ug 2015 D r ink i ng W a ter only EPA Crop Def Res A dj.Facto r s Comment Code Grp Commodity Name ( ppm ) Ill 112


## --·------- -- -- --- - --- - -- - ---------------- -------·-- - ------ 8601000000 86A water, direct, all sources 0
. 054500 1.000 1.000 8602000000 868 Water, indirect, all sources 0
. 054500 l.000 1.000



### P age 9of11Hym exazo l Diet ary Exposure and Risk Assessment 

### Attachment 3 Ac ut e Di e ta ry R es ult s (Drinkin g Water onl y)

US EPA DEEM-FCID ACUTE Analysis for 129107 HYMEXAZOL Residue file: 129107 Hymexazol _Ac ute

_ I npu t File

_ Reg Adjustment factor #2 N OT used. Ver. 3.18, 03-08-d NHANES 2003-2008 2-Day Rev Sept 2015

_ Wa ter only
. r08 Analysis Date: 10-01

- 2015/14:48:00 Residue file dated: 10 -0 1-201 5 /14 :3 9:06 NOEL (Acute) 

### = 150.000000 mg/kg body

- wt/day RAC/FF intake summed over 24 hours Run Comment: " 129107 Hymexazol Reg Rev Aug 2015 Drinking Wa ter only"
== == == == === = === == 2a = = === == === = ========================================== = === = == S umm ary calculations--per capita: 95th Percentile-

- - - 99th Percentile-

--- - -- 99.9th Percentile---- Exposure t aRfD MOE Exposure t aRfD MOE Exposure t aRfD MOE



### - --- -- - -- - - --- -- - 

### - - --- - -- -------- .. 

### - 

## -·-·--- ... 

## - .. 

### - ........ 

### - 

## ------- --- -- -- --- 

### - - --- - -- Total us Po pu lation: 0.003631 0 .24 41305 0.005988 0
. 40 25048 0.011376 0
. 76 13185 All Infants : 0.011374 0.76 13187 0.015407 1.03 9736 0.022580 1. 5 1 6642 Children 1-2:

0.005600 0.37 26786 0.008432 0
. 56 17788 0.020766 1.38 7223 Children 3-5: 0
. 004544 0 .30 33011 0.006959 0 .4 6 2 1554 0 .011170 0.7 4 13428 Children 6-12: 0.003472 0 .2 3 43204 0.005698 0
. 38 26325 0.008782 0.59 17080 Youth 13-19:

0.00302 4 0
. 20 49597 0.004981 0
. 33 30113 0
. 007521 0.50 19944 Adults 20- 49: 0.003574 0 .24 41974 0.005318 0
. 35 2820 5 0.007737 0
. 52 19387 Adults 50-99 : 0
. 003183 0
. 21 47120 0.00 4 827 0.32 31076 0.007608 0 .51 19714 Female 13-49:

0.003625 0.2 4 41384 0.005330 0
. 36 28143 0.007475 0.50 20067

Page 10 of 11 DP No. D429383H ymexazo l Dietary Ex pos ure a nd R isk Assess m e n

t D P No
. D4 293 8 3 Attachment 4 C hronic Dietary Re s ults (Drinking Wat e r only)

US EPA Ver. 3.16, 03-08-d DEEM-FCID Chronic analysis for 129107 HYMEXAZOL NHANES 2003-2008 2-day Residue file name : E:\Hymexazol\129 1 07 Hymexazol _C hronic_Input File

_ Reg Rev Sept 2015_Water only.r08 Adjustment factor tt2 used. Analysis Date 10-01-2015/14:50:17 Residue file dated: 10-01-2015/14:38 : 47 Reference dose (RfD, Chronic) = .31 m g/k g bw/ da y COMMENT l: 129107 Hymexazol Reg Rev Aug 2015 Drinking Water only**=== ·==** **== ===============** **== ~=** **=== =========** **====== ================** **===============** Tot a l exposure by population sub g roup



### ------ - ------- ----- ---- - ------- ---- - - -- - - ----------- - - -- - - ----------- - -- -- - -- -- Population

Subgroup Total us Population Hispanic Non-Hisp

- White Non -Hi sp -Bl ack Non

- Hisp-Other Nursing Infants Non -Nu rsing Infants Female 13+ PREG Children 1-6 Children 7-1 2 Male 13-19 Female 13-19/NP Male 20+ Female 20+/NP Seniors 55+ All Infants Female 13

- SO Children 1-2 Children 3-5 Children 6-12 Youth 13-19 Adults 20-49 Adults 50-99 Female 13-49 Total Exposure mg/kg body wt/day

0.001141 0
. 001090 0
. 001174 0.000942 0
. 001315 0.001032 0.003796 0
. 001075 0.001462 0.000951 0
. 000784 0.000879 0.001063 0
. 001199 0 .001103 0.002943 0
. 001136 0.001646 0.001387 0
. 001000 0.000832 0. 001139 0.001126 0
. 001134 Percent of Rfd 0.4\ 0 .4\ 0.4\ 0. 3t 0 .4\ 0 .3\ l. 2t 0. 3t 0.5t 0.3t 0 .3\ 0.3\ 0. 3t 0 .4\ 0.4\- 0.9\- 0.4t 0.St 0.4\- 0 .)t 0.3\- 0.4\- 0 .4\- 0.4t



### - -- --- -- ---------- - - -- ---- --- - -- - ---- ---- -- --- -- --------- --- --------- --- -- --- --

P

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