51674 Federal Register / Vol. 62, No. 191 / Thursday, October 2, 1997 / Notices

DEPARTMENT OF HEALTH AND

HUMAN SERVICES

Public Health Service

National Toxicology Program

National Toxicology Program (NTP)

Board of Scientific Counselors’ Meeting;

Review of Substances for Listing in or

Delisting from the 9th Report on

Carcinogens.

Pursuant to Pub. L. 92–463, notice is

hereby given of the next meeting of the

NTP Board of Scientific Counselors’

Report on Carcinogens Subcommittee to

be held on October 30 & 31, 1997, in the

Conference Center, Building 101, South

Campus, National Institute of

Environmental Health Sciences

(NIEHS), 111 Alexander Drive, Research

Triangle Park, North Carolina. The

meeting will begin at 8:30 a.m. both

days and is open to the public. The

agenda are the peer review of substances

nominated for listing in or delisting

from the 9th Report on Carcinogens

(formerly the Biennial Report on

Carcinogens), and provision of an

opportunity for public input.

Background

Over the past three years, there was

an extensive public and Federal

interagency review of the process for the

preparation of the Report on

Carcinogens (RC) to broaden input to its

preparation, broaden the scope of

scientific review, and provide review of

the criteria used for inclusion in or

removal of substances from the Report.

As a result, the criteria were revised and

approved in September 1996 by the

Secretary, Department of Health and

Human Services. The major change in

the RC which occurred as a result of the

criteria revision was to include

consideration of all relevant

information, including mechanistic

data, in the decision to list substances

in or delist substances from future

volumes. To broaden the scope of

scientific review, a new standing

subcommittee of the NTP Board of

Scientific Counselors was established. A

November 1996 meeting of the Report

on Carcinogens (RC) Subcommittee was

the first where public review of

nominations took place, and using the

revised criteria. Thus, the current

review process for review of petitions

considered by the NTP for listing in or

delisting from the Report begins with

initial scientific review by the NIEHS/

NTP Report on Carcinogens Review

Committee (RG1). The RG1 makes a

formal recommendation for those

petitions determined to contain

sufficient information for listing or

delisting in the Report. The second

scientific review is done by the NTP

Executive Committee’s Working Group

for the Report on Carcinogens (RG2).

RG2 is comprised of representatives of

the Federal health research and

regulatory agencies on the NTP

Executive Committee. Following

external scientific peer review by the RC

Subcommittee in public session and

solicitation of public comments through

announcements in the Federal Register

and other media, the independent

recommendations of the three review

groups and all public comments are

presented to the NTP Executive

Committee for review and comment.

The Director, NTP, receives the four

independent recommendations and

makes the final decision to submit the

Report to the Secretary for review and

approval.

Agenda

Tentatively scheduled to be peer

reviewed on October 30 & 31, are 14

agents, substances, mixtures or exposure

circumstances listed alphabetically,

along with supporting information in

the attached table. The table lists the

nominations in the tentative order of

their presentation and review, and gives

their primary uses or exposures and the

category for which they were originally

nominated. Background summary

documents on each of the substances

will be provided to reviewers around

October 1, and will be available to the

public at that time as well. Background

documents include (1) a summary of the

background data and information used

to evaluate the nomination, and (2) the

recommendation for: listing as ‘‘known

to be a human carcinogen’’ or as

‘‘reasonably anticipated to be a human

carcinogen’’; the upgrading of a current

listing; or the removal from the Report.

Copies of draft background documents

can be obtained, as available, from: the

Executive Secretary, Dr. Larry G. Hart,

P.O. Box 12233, Research Triangle Park,

NC 27709 (telephone 919/541–3971;

FAX 919/541–0295; email hart@

niehs.nih.gov.

Public Input Encouraged

The entire meeting is open to the

public and time will be provided for

public comment on each of the

substances being reviewed. In order to

facilitate planning for the meeting,

persons wanting to make a formal

presentation regarding a particular

nominated substance must notify the

Executive Secretary by telephone, by

FAX, by mail, or by email no later than

October 23, 1997, and provide a written

copy in advance of the meeting. Written

statements should supplement and may

expand on the oral presentation, or may

be submitted in lieu of an oral

presentation, and should be received by

October 27 so copies can be made for

distribution to Subcommittee members

and staff and made available for the

public. Oral presentation should be

limited to no more than five minutes.

Should the requests for time exceed the

likely available time, the time may have

to be limited to three minutes and

presenters will be contacted.

The program would welcome

receiving carcinogenesis information

from completed, ongoing, or planned

studies by others, as well as current

production data, human exposure

information, and use patterns for any of

the substances listed in this

announcement. Please contact Dr. C.W.

Jameson, Report on Carcinogens, MD

EC–14, P.O. Box 12233, Research

Triangle Park, NC 27709 (919/541–4096;

FAX 919/541–2242).

The Executive Secretary, Dr. Larry G.

Hart, at the address given above, will

furnish agenda and a roster of

Subcommittee members prior to the

meeting. Summary minutes subsequent

to the meeting will be available upon

request.

Dated: September 23, 1997.

Samuel H. Wilson,

Deputy Director, National Toxicology

Program.
Federal Register / Vol. 62, No. 191 / Thursday, October 2, 1997 / Notices 51675

SUMMARY DATA FOR AGENTS, SUBSTANCES, MIXTURES OR EXPOSURE CIRCUMSTANCES TENTATIVELY SCHEDULED FOR

REVIEW AT THE MEETING OF THE NTP BOARD OF SCIENTIFIC COUNSELORS’ REPORT ON CARCINOGENS SUBCOMMITTEE OCTOBER 30, AND 31, 1997

Substance or exposure circumstance/CAS No. Primary uses or exposures Nominated for 1 Tenative review order

Dyes metabolized to benzidine

(Benzidine dyes as a class).

Benzidine-based dyes are used primarily for dyeing

textiles, paper and leather products. More than 250

benzidine-based dyes have been reported by the

Society of Dyers and Colorists.

Listing as Known to be a Human

Carcinogen in the 9th Report.

14

1,3-Butadiene/106–99–0 .................. Used primarily as a chemical intermediate and polymer component in the manufacture of synthetic

rubber.

Upgrading current listing to Known

to be a Human Carcinogen in the

9th Report.

4

Cadmium and cadmium compounds/

7440–43–9.

Used in batteries, coating and plating, plastic and

synthetic products and in alloys.

Upgrading current listing to Known

to be a Human Carcinogen in the

9th Report.

2

Chloroprene/126–99–8 ..................... Used as a monomer for neoprene elastomers, industrial rubber products, and as a component of adhesives in food packaging.Listing as Reasonably Anticipated

to be a Human Carcinogen in the

9th Report.

3

Phenolphthalein/77–09–8 ................. Used as a laboratory reagent and acid-base indicator

and as a cathartic drug in over-the-counter laxative

preparations.

Listing as Reasonably Anticipated

to be a Human Carcinogen in the

9th Report.

10

Saccharin/281–44–9 ......................... Used primarily as a nonnutritive sweetening agent .... Removal from the Report on

Charcinogens.

11

Smokeless tobacco .......................... Oral use of smokeless tobacco products .................... Listing as Known to be a Human

Carcinogen in the 9th Report.

7

Strong inorganic acid mists containing sulfuric acid.Used in the manufacture of fertilizers, rayon, and

other fibers, pigments and colors, explosives, plastics, coal-tar products such as dyes and drugs,

storage batteries, synthetic detergents, natural and

synthetic rubber, pulp and paper, cellophone and

catalysts. It is also used in petroleum refining, pickling iron, steel and other metals and in ore concentration.

Listing as Known to be a Human

Carcinogen in the 9th Report.

8

Tamoxifen/10540–29–1 .................... Used as an anti-estrogen drug and in the palliative

treatment of breast cancer.

Listing as Known to be a Human

Carcinogen in the 9th Report.

9

2,3,7,8-Tetrachorodibenzo-P-Dioxin

(TCDD)/1746–01–6.

Not used commercially, used only as a research

chemical. Potential exposure from municipal incinerators, dump sites and contaminated soil.

Upgrading current listing to Known

to be a Human Carcinogen in the

9th Report.

12

Tetrafluoroethylene/116–14–3 .......... Used in the production of polytetrafluoroethylene

(Teflon) and other polymers. Has also been used

as a propellant for food product aerosols.

Listing as Reasonably Anticipated

to be a Human Carcinogen in the

9th Report.

1

Tobacco smoking ............................. Inhalation of tobacco smoke ....................................... Listing as Known to be a Human

Carcinogen in the 9th Report.

6

Tricholoroethylene/79–01–6 ............. Used as an industrial solvent for vapor degreasing

and cold cleaning of fabricated metal parts. Has

also been used as a carrier solvent for the active

ingredients of insecticides and fungicides, as a solvent for waxes, fats, resins, and oils, as an anesthetic for medical and dental use, and as an extractant for spice oleoresins and for caffeine from

coffee.

Listing as Reasonably Anticipated

to be a Human Carcinogen in the

9th Report.

13

UV radiation ...................................... Solar and artificial sources of ultraviolent radiation .... Listing as Known to be a Human

Carcinogen in the 9th Report.

5

1 Nomination does not necessarily reflect the final recommendaiton of the two NTP Scientific Review Committees for the Report on Carcinogens.

[FR Doc. 97–26169 Filed 10–1–97; 8:45 am]

BILLING CODE 4140–01–M

DEPARTMENT OF THE INTERIOR

Fish and Wildlife Service

Notice of Receipt of Applications for

Permit

The following applicants have

applied for a permit to conduct certain

activities with endangered species. This

notice is provided pursuant to Section

10(c) of the Endangered Species Act of

1973, as amended (16 U.S.C. 1531, et

seq.):

PRT–834504

Applicant: Zoological Society of San Diego,

San Diego, CA

The applicant requests a permit to

import one captive-born Black-footed

cat (Felis nigripes nigripes) from the

Frankfurt Zoo, Frankfurt, Germany, for

the purpose of enhancement of the

species through captive propagation.

PRT–831854

Applicant: Thure Cerling, University of Utah,

Salt Lake City, UT

The applicant requests a permit to

import molar fragments from Black

rhinoceros (Diceros bicornis) collected

in the wild in Kenya, from skeletal

remains found in the National Parks of

Kenya, or from existing material

archived in the National Museums of

Kenya, for scientific research.

Written data or comments should be

submitted to the Director, U.S. Fish and

Wildlife Service, Office of Management