Exhibit
12.1





Computation
of


Ratio of
Earnings to Fixed Charges





Year
      Ended December 31,(amounts in thousands)
                      
                      2008
                      
                      
                      2007
                      
                      
                      2006
                      
                      
                      2005
                      
                      
                      2004Loss
      before income taxes and cumulative effectof
      adoption of and change in accounting principles
                      
                      $
                      (16,556
                      )
                      
                      $
                      (19,429
                      )
                      
                      $
                      (10,742
                      )
                      
                      $
                      (23,445
                      )
                      
                      $
                      (44,158
                      )Plus
      fixed charges:Interest
      expense
                      
                      
                      1,374
                      
                      
                      
                      2,070
                      
                      
                      
                      2,047
                      
                      
                      
                      4,623
                      
                      
                      
                      6,103Amortization
      of costs related to indebtedness
                      
                      
                      567
                      
                      
                      
                      1,536
                      
                      
                      
                      2,308
                      
                      
                      
                      5,521
                      
                      
                      
                      6,792Estimated
      interest factor in rent expense (1)
                      
                      
                      660
                      
                      
                      
                      512
                      
                      
                      
                      482
                      
                      
                      
                      391
                      
                      
                      
                      455Total
      Fixed Charges
                      
                      
                      2,601
                      
                      
                      
                      4,118
                      
                      
                      
                      4,837
                      
                      
                      
                      10,535
                      
                      
                      
                      13,350Adjusted
      loss
                      
                      
                      (13,955
                      )
                      
                      
                      (15,311
                      )
                      
                      
                      (5,905
                      )
                      
                      
                      (12,910
                      )
                      
                      
                      (30,808
                      )Fixed
      charges
                      
                      
                      2,601
                      
                      
                      
                      4,118
                      
                      
                      
                      4,837
                      
                      
                      
                      10,535
                      
                      
                      
                      13,350Deficiency
      in earnings to cover fixed charges
                      
                      $
                      (16,556
                      )
                      
                      $
                      (19,429
                      )
                      
                      $
                      (10,742
                      )
                      
                      $
                      (23,445
                      )
                      
                      $
                      (44,158
                      )Ratio
      of earnings to fixed charges
                      
                      
                      *
                      
                      
                      
                      *
                      
                      
                      
                      *
                      
                      
                      
                      *
                      
                      
                      
                      *





*
Calculation not meaningful as ratio is less than 1.


(1) The
interest factor in rent expense is estimated as one-third of rental
expense.