United States Chemical Safety June 2011

Environmental Protection and Pollution Prevention

Agency (7510P)

Bronopol

Summary Document:

Registration Review: Initial Docket

June 2011

Docket Number: EPA-HQ-OPP-2011-0421

www.regulations.gov

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TABLE OF CONTENTS

Bronopol Registration Review Team...................................................................................4

I. Preliminary Work Plan .....................................................................................................5

II. Fact Sheet ......................................................................................................................12

III. Summary of Anticipated Data Requirements..............................................................20

IV. Appendix A..................................................................................................................22

________________________________________

Please Note

This Preliminary Work Plan and Fact Sheet summarize the Environmental Protection Agency's 

current position based on the following documents:

1. Summary of Product Chemistry, Environmental Fate, and Ecotoxicity Data for the 

Bronopol Registration Review Decision Document. April 25, 2011

2. 2-Bromo-2-nitropropane-1,3-diol. Human Health Effects Scoping Document for the 

Registration Review Decision. April 19, 2011

Additional supporting documents for the Bronopol Case may be found in the registration review 

docket EPA-HQ-OPP-2011-0421 located on the internet at www.regulations.gov.
Docket Number: EPA-HQ-OPP-2011-0421

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Bronopol Registration Review Team

William Hazel

Human Health & Environmental Effects

Srinivas Gowda

Eliza Blair

Risk Management

Lance Wormell

Philip Ross

Office of General Counsel
Docket Number: EPA-HQ-OPP-2011-0421

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I. Preliminary Work Plan -- Bronopol

The Food Quality Protection Act (FQPA) of 1996 mandated a registration review program. All 

pesticides distributed or sold in the United States generally must be registered by the U.S. 

Environmental Protection Agency (USEPA, EPA, or the Agency) based on scientific data 

showing that they will not cause unreasonable risks to human health or the environment when 

used as directed on product labeling. The registration review program is intended to make sure 

that, as the ability to assess risk evolves and as policies and practices change, all registered 

pesticides continue to meet the statutory standard of no unreasonable adverse effects to human 

health or the environment. Changes in science, public policy, and pesticide use practices will 

occur over time. Through the registration review program, the Agency periodically reevaluates 

pesticides to make sure that as change occurs, products in the marketplace can be used safely. 

Information on this program is provided at 

Introduction:

http://www.epa.gov/oppsrrd1/registration_review/.

The Agency is implementing the registration review program pursuant to Section 3(g) of the 

Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and will review each registered 

pesticide every 15 years to determine whether it continues to meet the FIFRA standard for 

registration. The Agency will consider benefits information and data as required by FIFRA. The 

public phase of registration review begins when the initial docket is opened for each case. The 

docket is the Agency’s opportunity to state what it knows about the pesticide and what additional 

risk analyses and data or information it believes are needed to make a registration review 

decision. After reviewing and responding to comments and data received in the docket during 

this initial comment period, the Agency will develop and commit to a final work plan and 

schedule for the Bronopol Case.

The Bronopol case (Case 2770) contains one active ingredient, 2-Bromo-2-nitro-1,3-propanediol 

(Bronopol) (PC Code 216400). The first product containing Bronopol as an active ingredient 

was registered in the United States in 1987. Currently, there are 42 products registered with EPA. 

Bronopol is a bacteriostat, fungicide, microbicide, microbiostat, antimicrobial, and algaecide. 

Products containing bronopol are registered for use as a materials preservative, in industrial 

process water systems, and in HVAC systems. It is registered for use to preserve adhesives, 

metalworking fluids, absorbent clay, starch slurries, pigment slurries, mineral slurries, paints, 

emulsion systems, water-based printing inks and fountain solutions, paper, and bulk pulp. The 

following water systems uses are registered: paper mill process water systems, recirculating 

water cooling towers, evaporative condensers, air scrubber systems, air conditioning systems, 

humidifying systems, oil and gas drilling fluids, and oil and gas pipeline maintenance. For

HVAC systems the following uses are registered: furnaces, air handlers, coils, fans, fan housings, 

sheet metal ducts, air supply and return ducts, humidifiers, dehumidifiers, and air intake and 

discharge devices. Bronopol has been widely used for decades as a preservative in 

pharmaceuticals, cosmetics, and other personal care products regulated by the Food & Drug 

Administration (FDA). Bronopol is exempt from the requirement of a tolerance when used at 

≤400 ppm as an inert ingredient in conventional pesticide products used on crops (40 CFR 

§180.910) and animals (40 CFR §180.930). 

The Agency completed a Reregistration Eligibility Decision (RED) for Bronopol in 1995. 
Docket Number: EPA-HQ-OPP-2011-0421

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Documents associated with the registration review of Bronopol can be viewed at 

www.regulations.gov in docket EPA-HQ-OPP-2011-0421. Below is a summary of the issues 

relevant to this registration review case.

EPA believes that Bronopol releases formaldehyde (HCHO) under certain conditions; therefore, 

this Registration Review also addresses potential risks associated with formaldehyde exposure 

from Bronopol use. Products containing formaldehyde as an active ingredient will be evaluated 

under registration review Case 0556. EPA’s formaldehyde RED is available in the formaldehyde 

public docket at http://www.regulations.gov in docket number EPA-HQ-OPP-2008-0121.

The Agency anticipates the need to conduct a comprehensive ecological risk assessment, 

including an endangered species risk assessment, for all uses of Bronopol. The Agency 

anticipates the need to conduct a human health risk assessment. The Agency anticipates needing 

additional data for use in the registration review for Bronopol.

Anticipated Risk Assessment and Data Needs:

Ecological Risk:

• No recent ecological risk assessment has been performed for Bronopol. 

• The Agency has not conducted a risk assessment that supports a complete endangered 

species determination for Bronopol. The ecological risk assessment planned during 

registration review will allow the Agency to determine whether Bronopol’s use has 'no 

effect' or 'may affect' federally listed threatened or endangered species (listed species) or 

their designated critical habitats. When an assessment concludes that a pesticide’s use 

'may affect' a listed species or its designated critical habitat, the Agency will consult with 

the U.S. Fish and Wildlife Service and/or National Marine Fisheries Services (the 

Services), as appropriate.

• The Agency anticipates the need to require the following additional ecological data for 

use in the registration review of Bronopol.

850.1300 -- Daphnid chronic toxicity test

850.1400 -- Fish early-life stage toxicity test (freshwater)

850.4225 -- Seedling emergence, Tier II - dose response study on rice (Oryza sativa);

850.4250 -- Vegetative vigor, Tier II - dose response study on rice (Oryza sativa);

850.4400 -- Aquatic plant growth (aquatic vascular plant toxicity), Tier II - using 

Lemna gibba, Tier I

850.5400 -- Aquatic plant growth (algal toxicity), Tier II - dose response studies on 

four species

• The Agency anticipates the need to require the following additional environmental fate 

data for use in the registration review of Bronopol.

850.6800 -- Modified activated sludge, respiration inhibition test

835.3110 -- Ready Biodegradability
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835.3280 -- Simulation Tests to Assess the Biodegradability of Chemicals Discharged 

to Wastewater

• For more information, please refer to Summary of Product Chemistry, Environmental 

Fate, and Ecotoxicity Data for the Bronopol Registration Review Decision Document, 

located in the docket.

Human Health Risk: 

• No recent human health risk assessment has been performed for Bronopol. The Agency 

anticipates the need to require the following additional human health data for use in the 

registration review of Bronopol.

870.3465 -- 90-day inhalation toxicity (rat)

875.1700 -- Product use information (outdoor)

875.2700 -- Product use information (indoor)

875.2800 -- Description of human activity

875.1100 -- Dermal outdoor exposure

875.1200 -- Dermal indoor exposure

875.1300 -- Inhalation outdoor exposure

875.1400 -- Inhalation indoor exposure

875.1600 -- Application exposure data reporting and calculations

875.2900 -- Data reporting and calculations

• For more information, please refer to 2-Bromo-2-nitropropane-1,3-diol. Human Health 

Effects Scoping Document for the Registration Review Decision, located in the docket.

Product Chemistry:

• The Agency does not anticipate the need to require additional product chemistry data for 

use in the registration review at this time.

• For more information, please refer to Summary of Product Chemistry, Environmental 

Fate, and Ecotoxicity Data for the Bronopol Registration Review Decision Document, 

located in the docket.

As required by FIFRA and FFDCA, EPA reviews numerous studies to assess potential adverse 

outcomes from exposure to chemicals. Collectively, these studies include acute, subchronic and 

chronic toxicity, including assessments of carcinogenicity, neurotoxicity, developmental, 

reproductive, and general or systemic toxicity. These studies include endpoints which may be 

susceptible to endocrine influence, including effects on endocrine target organ histopathology, 

organ weights, estrus cyclicity, sexual maturation, fertility, pregnancy rates, reproductive loss, 

and sex ratios in offspring. For ecological hazard assessments, EPA evaluates acute tests and 

chronic studies that assess growth, developmental and reproductive effects in different 

taxonomic groups. As part of its most recent registration decision, EPA reviewed these data and 

Endocrine Disruptor Screening Program
Docket Number: EPA-HQ-OPP-2011-0421

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selected the most sensitive endpoints for relevant risk assessment scenarios from the existing 

hazard database. However, as required by FFDCA section 408(p), Bronopol is subject to the 

endocrine screening part of the Endocrine Disruptor Screening Program (EDSP). 

EPA has developed the EDSP to determine whether certain substances (including pesticide 

active and other ingredients) may have an effect in humans or wildlife similar to an effect 

produced by a “naturally occurring estrogen, or other such endocrine effects as the Administrator 

may designate.” The EDSP employs a two-tiered approach to making the statutorily required 

determinations. Tier 1 consists of a battery of 11 screening assays to identify the potential of a 

chemical substance to interact with the estrogen, androgen, or thyroid (E, A, or T) hormonal 

systems. Chemicals that go through Tier 1 screening and are found to have the potential to 

interact with E, A, or T hormonal systems will proceed to the next stage of the EDSP where EPA 

will determine which, if any, of the Tier 2 tests are necessary based on the available data. Tier 2 

testing is designed to identify any adverse endocrine-related effects caused by the substance, and 

establish a dose-response relationship between the dose and the E, A, or T effect.

Under FFDCA section 408(p), the Agency must screen all pesticide chemicals. Between 

October 2009 and February 2010, EPA issued test orders/data call-ins for the first group of 67 

chemicals, which contains 58 pesticide active ingredients and 9 inert ingredients. Bronopol is 

not among the group of 58 pesticide active ingredients on the initial list to be screened under the 

EDSP. Accordingly, as part of registration review, EPA will issue future EDSP orders/data callins, requiring the submission of EDSP screening assays for Bronopol. For further information on 

the status of the EDSP, the policies and procedures, the list of 67 chemicals, future lists, the test 

guidelines and the Tier 1 screening battery, please visit our website: http://www.epa.gov/endo/.

EPA has created the following estimated timeline for the completion of the Bronopol registration 

review:

Timeline

Anticipated Schedule

Activities Estimated Month/Year

Phase 1: Opening the docket

Open Public Comment Period for Docket June 2011

Close Public Comment Period for Docket August 2011

Phase 2: Case Development

Develop Final Work Plan (FWP) December 2011

Issue DCI December 2012

Data Submission December 2014

Open Public Comment Period for Preliminary Risk Assessments June 2016

Close Public Comment Period for Preliminary Risk Assessments August 2016

Phase 3: Registration Review Decision

Open Public Comment Period for Proposed Reg. Review Decision December 2016

Close Public Comment Period for Proposed Reg. Review Decision February 2017
Docket Number: EPA-HQ-OPP-2011-0421

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Final Decision and Begin Post-Decision Follow-up 2017

Total (years) 5.5

The public is invited to comment on EPA’s Preliminary Work Plan and rationale. The Agency 

will carefully consider all comments as well as any additional information or data provided in a 

timely manner prior to issuing a final work plan for the Bronopol registration review case.

Guidance for Commenters:

Through the registration review process, the Agency intends to solicit information on trade 

irritants and, to the extent feasible, take steps toward facilitating irritant resolution. Growers and 

other stakeholders are asked to comment on any trade irritant issues resulting from lack of 

Maximum Residue Limits (MRLs) or disparities between U.S. tolerances and MRLs in key 

export markets, providing as much specificity as possible regarding the nature of the concern. 

Trade Irritants:

Bronopol is not identified as a cause of impairment for any water bodies listed as impaired 

under section 303(d) of the Clean Water Act, based on information provided at 

Water Quality:

http://iaspub.epa.gov/tmdl_waters10/attains_nation_cy.cause_detail_303d?p_cause_group_id=88

5. In addition, no Total Maximum Daily Loads (TMDL) have been developed for Bronopol, 

based on information provided at 

http://iaspub.epa.gov/tmdl_waters10/attains_nation.tmdl_pollutant_detail?p_pollutant_group_id

=885&p_pollutant_group_name=PESTICIDES

More information on impaired water bodies and TMDLs can be found at 

.

http://www.epa.gov/owow/tmdl/. The Agency invites submission of water quality data for this 

pesticide. To the extent possible, data should conform to the quality standards in Appendix A of 

the OPP Standard Operating Procedure: Inclusion of Impaired Water Body and Other Water 

Quality Data in OPP’s Registration Review Risk Assessment and Management Process (see: 

http://www.epa.gov/oppsrrd1/registration_review/water_quality_sop.htm), in order to ensure the 

data can be used quantitatively or qualitatively in pesticide risk assessments.

EPA seeks to achieve environmental justice, the fair treatment and meaningful involvement of all 

people, regardless of race, color, national origin, or income, in the development, implementation, 

and enforcement of environmental laws, regulations, and policies. To help address potential 

environmental justice issues, the Agency seeks information on any groups or segments of the 

population who, as a result of their location, cultural practices, or other factors, may have 

atypical, unusually high exposure to Bronopol compared to the general population. Please 

comment if you are aware of any sub-populations that may have atypical, unusually high 

exposure compared to the general population.

Environmental Justice:
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EPA must rely upon information of appropriate quality and reliability for each decision made by 

the Agency. In the Office of Pesticide Programs (OPP), the evaluation process for a pesticide 

chemical traditionally begins with the applicant’s submission of a set of studies conducted with 

the specific pesticide chemical of interest. The use of the results of such testing (measured data) 

is a logical, scientifically rigorous process that identifies the physical, chemical, and 

environmental fate properties of the pesticide, as well as the dose and endpoints at which an 

adverse effect can occur in various animal species. 

Structure Activity Relationships: 

Today, there is significant interest in alternative techniques, i.e., techniques other than data 

generation that could significantly inform the Agency’s decision-making process. Recently, 

OPP has made increasing use of structure activity relationship (SAR) as part of its regulatory 

decision-making process. In the SAR process, a chemical's molecular structure is compared to 

that of other chemicals for which data are available. These structural similarities are then used to 

make predictive judgments about a chemical’s physical, chemical, and biological properties. 

Thus, the chemical’s physical, chemical, and biological properties are a function of (or directly 

related to) the chemical’s molecular structure. Quantitative SAR is referred to as QSAR. To 

develop a QSAR, a selected set of measured data on a single physical, chemical, or biological 

property is used to derive a model (an equation) to predict the value of that property. 

Since SAR assessments and QSAR modeling are another set of tools that are available to Agency 

scientists, OPP has begun a process shift that envisions shifting from the current study-by-study 

approach to an approach in which the use of predicted data, generated using validated models, is 

considered along with information from open literature and studies specifically generated under 

Part 161 requirements. All relevant information would be considered as part of a weight-of-theevidence evaluation. 

At this time, EPA believes that for certain endpoints, especially physical/chemical and fate 

properties, that SAR and QSAR might be effectively utilized to fulfill these data requirements 

for many antimicrobial pesticide chemicals. When considering biological properties, at this 

time, EPA believes that SAR and QSAR can be most effectively utilized in the evaluation of 

chemicals that exhibit lower toxicity for human health and/or ecotoxicity parameters. This is 

appropriate because the risk assessment for lower toxicity chemicals can be stream-lined, i.e., a 

screening-level assessment procedure rather than multiple tiers of assessments with progressively 

more data requirements.

If stakeholders believe that submission of predicted data can fulfill one of the data needs for the 

Bronopol case, then the Agency invites submission of this information. The submitter would be 

expected to supply a rationale describing the utility of the information and provide 

documentation on the scientific validity of the information. The determination that the predicted 

data fulfills the data requirement would be at the sole discretion of the Agency. Pre-submission 

consultation with the Agency is encouraged.

Additional Information:
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Stakeholders are also specifically asked to provide available information and data that will assist 

the Agency in refining its risk assessments, including any species-specific ecological effects 

determinations. The Agency is interested in receiving the following information:

1. Confirmation on the following label information:

a. Sites of application

b. Formulations

c. Application methods and equipment

d. Maximum application rates

e. Frequency of application, application intervals and maximum number of 

applications

f. Geographic limitations on use

2. Use or potential use distribution

3. Use history

4. Usage/use information for non-agricultural uses (e.g., materials preservation)

5. Typical application interval

6. State or local use restrictions

7. Ecological incidents (non-target plant damage and avian, fish, reptilian, amphibian 

and mammalian mortalities) not already reported to the Agency

8. Monitoring data

Next Steps:

After the 60-day comment period closes in August 2011, the Agency will review and respond to 

any comments received in a timely manner, and then issue a Final Work Plan for the Bronopol

Case. 
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II. Fact Sheet

• Active Ingredient: 2-Bromo-2-nitro-1,3-propanediol (Bronopol)

Background Information:

• Case number: 2770

• PC Code: 216400

• CAS number: 52-51-7

• Technical registrants: Dow Chemical, BASF Corporation, Lanxess

• First approved for use in a registered product: 1984

• Bronopol is exempt from the requirement of a tolerance when used at ≤400 ppm as an 

inert ingredient in conventional pesticide products used on crops (40 CFR §180.910) and 

animals (40 CFR §180.930).

• Antimicrobials Division Chemical Review Manager (CRM): Eliza Blair, 

blair.eliza@epa.gov

• Antimicrobials Division Product Manager (PM): Marshall Swindell, 

swindell.marshall@epa.gov

• Chemical Structure: 

• Bronopol is a bacteriostat, fungicide, microbicide, microbiostat, antimicrobial, and 

algaecide. Bronopol is registered for use as a materials preservative, in industrial process 

water systems, and in HVAC systems. It is registered for use to preserve adhesives, 

metalworking fluids, absorbent clay, starch slurries, pigment slurries, mineral slurries, 

paints, emulsion systems, water-based printing inks and fountain solutions, paper, and 

bulk pulp. The following water systems uses are registered: paper mill process water 

systems, recirculating water cooling towers, evaporative condensers, air scrubber 

systems, air conditioning systems, humidifying systems, oil and gas drilling fluids, and 

oil and gas pipeline maintenance. For HVAC systems the following uses are registered: 

furnaces, air handlers, coils, fans, fan housings, sheet metal ducts, air supply and return 

ducts, humidifiers, dehumidifiers, and air intake and discharge devices. Bronopol has 

been widely used for decades as a preservative in pharmaceuticals, cosmetics, and other 

personal care products regulated by the Food & Drug Administration (FDA).

Use & Usage Information:

• On November 9, 2005, the Agency issued a ruling exempting Bronopol from the 

requirement of a tolerance when used as an inert ingredient in-can preservative at ≤400 

ppm when applied to growing crops or to raw agricultural commodities after harvest 

under 40 CFR 180.910, and when applied to animals under 40 CFR 180.930. This ruling 

Recent/Pending Regulatory Actions:
Docket Number: EPA-HQ-OPP-2011-0421

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was a response to a tolerance exemption petition filed by BASF Corporation and 

announced in the Federal Register on December 24, 2002.

Please refer to Summary of Product Chemistry, Environmental Fate, and Ecotoxicity Data for 

the Bronopol Registration Review Decision Document, located in the docket, for a detailed 

discussion of the ecological risk assessments.

Ecological Risk Assessment Status:

• No recent ecological risk assessment has been performed for Bronopol because minimial 

environmental exposure was expected based on the uses registered at that time. 

• Bronopol uses registered after the RED that have potential for environmental exposure 

are materials preservatives and industrial slimicides used in recirculating water cooling 

towers and paper mills discharges. 

• The Agency has not conducted a risk assessment for Bronopol that supports a complete 

endangered species effects determination. The ecological risk assessment planned during 

registration review will allow the Agency to determine whether Bronopol’s use has “no 

effect or “may affect” federally listed threatened or endangered species (listed species) or 

their designed critical habitats. When an assessment concludes that a pesticide’s use 

“may affect” a listed species or its designated critical habitat, the Agency will consult 

with the U.S. Fish and Wildlife Service and/or National Marine Fisheries Services (the 

Services), as appropriate.

• No recent environmental fate assessment has been performed for Bronopol. 

The most recent human health risk assessment for Bronopol was conducted for the 1995 

Reregistration Eligibility Decision (RED). 

Human Health Risk Assessment Status:

The following are key findings of the recent human health risk assessments for Bronopol. Please 

refer to 2-Bromo-2-nitropropane-1,3-diol. Human Health Effects Scoping Document for the 

Registration Review Decision, located in the docket, for a detailed discussion of the human 

health risk assessment.

Hazard Characterization:

• Formaldehyde may be released from Bronopol under certain conditions, though it does 

not appear to be Bronopol’s main mechanism of antimicrobial action. The Agency

anticipates the need for further data to determine the conditions and extent of this release. 

The hazard database for formaldehyde is adequate as discussed in the 2008 

Formaldehyde Reregistration Eligibility Decision document. However, the toxicity 

endpoints for use in risk assessment remain the subject of much public discussion and 

scientific evaluation by a number of EPA offices, industry groups, scholars, and other 

government agencies. These official endpoints may be subject to change before, during or 
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after the Registration Review risk assessment for Bronopol; the Agency will assess 

formaldehyde risks based on the most up-to-date official endpoints available at the time.

Dietary (Food and Water):

• A dietary risk assessment was conducted in 2005 to support the exemption from the 

requirement of a tolerance when used at rates ≤ 400 ppm on crops and animals. At that time 

and using conservative assumptions, the Agency determined that this use would result in 

dietary exposure below levels of concern.

• Dietary (food) exposure could also potentially occur because Bronopol is used as an incan preservative or preservative during storage or use of materials including the 

following: bulk paper pulp, paper and paperboard water systems, water-based coatings, 

dishwashing liquids, and premoistened sponges and wipes. Residue transfer from these 

preserved materials to food may occur. The labels do not preclude food contact use of 

these materials; thus, a dietary assessment is now needed to characterize these exposures.

Residential:

• A residential risk assessment was not conducted for the 1995 RED; residential exposure to 

products containing Bronopol was considered minimal due to standard exposure assumptions 

at the time.

• Bronopol is intended for industrial materials preservative and water antifoulant use only. 

However, many of the materials preserved with Bronopol are intended for residential, 

commercial, and institutional use and may result in exposure of the general public and 

homeowners to the parent compound and formaldehyde. Such materials include latex 

paints, resin/latex/polymer emulsions, or detergent and polish suspensions. However, to 

determine whether residential or other nonoccupational exposure to the parent compound 

or formaldehyde is likely to occur from its use as a preservative, data is needed, including 

detailed information on physical and chemical properties and use information, to 

elucidate the conditions, rates, and magnitude of formaldehyde release from Bronopol 

under various conditions and in various materials. To estimate the extent that the parent 

compound remains and the levels of formaldehyde released into the air from preserved 

materials, small chamber studies are needed to better estimate potential residential 

exposure. This will include a residential painter study.

Aggregate:

• The Agency has not conducted an aggregate risk assessment for Bronopol.

• In examining aggregate exposure, EPA takes into account the available and reliable 

information concerning exposures to pesticide residues in food and drinking water, as 

well as non-occupational pesticide exposures. Dietary (food) exposure will potentially 

occur from registered uses of Bronopol. Bronopol residues may also reach drinking 

water as a result of industrial discharges. However, the potential for contamination of 

drinking water will be revisited upon receipt of biodegradability data as detailed below in 
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“Summary of Anticipated Data Requirements”. Residential painter and postapplication 

exposure of adults and children to a large number of Bronopol-preserved homeowner 

products are likely to occur. The specifics of necessary aggregate assessments will be 

determined during the risk assessment stage of Registration Review.

Occupational:

• For the 1995 RED, an occupational assessment was conducted which examined handlers’ 

mixing and loading exposure to Bronopol. At the time, risks were considered mitigated by 

mandating the use of personal protective equipment (PPE) for some occupational uses and 

closed loading such as by a metering pump for others. However, post-application exposures, 

as to Bronopol-containing paint, were not examined due to standard exposure assumptions at 

the time. The Agency now needs to examine these exposures as part of a comprehensive risk 

assessment for registration review.

• Bronopol products are added to preserve industrial materials during the manufacturing 

process using open-pour or metered pump application methods. During these processes, 

dermal exposure to workers is expected, especially when open-pour application is used. 

Further, Bronopol hydrolyzes to release formaldehyde which poses worker inhalation 

exposure concerns. Use of a metered pump is expected to reduce both dermal and 

inhalation exposures to formaldehyde. However, since the conditions under which 

Bronopol releases formaldehyde and the rate of release are unknown, the Agency cannot 

reliably estimate exposure to either the parent compound or formaldehyde. The major 

occupational exposures are likely to be inhalation of Bronopol and formaldehyde and 

dermal exposure to the parent compound, Bronopol. To determine exposure to 

formaldehyde associated with each occupational scenario, detailed information are 

needed on physical and chemical properties and use information to elucidate the 

conditions (pH, temperature, etc.), rates, and magnitude of formaldehyde release from 

Bronopol under various conditions and in various materials (EPA Guidelines 875.1700 

and 875.2700, Indoor and Outdoor Product Use Information). Small chamber studies are 

anticipated to be needed to estimate the magnitude of occupational (mixer/loader) 

formaldehyde inhalation exposure while preserving materials in the manufacturing 

facility, using treated metalworking fluids, paper and paperboard mill water systems, 

painting with preserved paint, and applying preserved coatings. Additionally, 

postapplication/bystander formaldehyde exposure data are needed to assess inhalation 

risks posed to workers in pulp and paper mills, machine shops, and other industrial 

facilities manufacturing preserved materials.

Cumulative:

• EPA does not have, at this time, available data to determine whether Bronopol has a 

common mechanism of toxicity with other substances or how to include this pesticide in 

a cumulative risk assessment. For the purposes of this Registration Review, EPA has 

assumed that Bronopol does not have a common mechanism of toxicity with other 

substances when used as an antimicrobial as registered.

Incidents:
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Ecological:

• No Bronopol ecological incidents have been reported in the OPP incident database.

Human Health:

• Four human poisoning incidents reported in the OPP incident database have been 

confirmed as being due to Bronopol exposure. These are summarized as follows:

o A residential use of a Bronopol product to treat HVAC ducts resulted in the 

homeowner becoming sick. No more detailed information was provided.

o A worker was splashed on the upper arm with approximately 2 ml of a 25% 

solution of Bronopol in water. The worker promptly washed the area with soap 

and water. The worker experienced no immediate pain. The exposed area began 

to itch later that evening and then blister. The worker went to a doctor who said it 

was a second degree burn.

o A worker who uses a printing press claims development of a chemical allergy to 

Bronopol.

o A man reported that he was sick after the HVAC system in his house was treated 

with a Bronopol product. The person began having some adverse reactions to the 

chemical treatment immediately after re-entering the house. The reactions 

became more intense until he finally had to leave the house.

Tolerances and International Harmonization:

• Bronopol is exempt from the requirement of a tolerance when used at ≤400 ppm as an 

inert ingredient in conventional pesticide products used on crops (40 CFR §180.910) and

animals (40 CFR §180.930)

• No recent data call-in has been issued for Bronopol. Since the Agency granted the 

tolerance exemption in 2005, several human health studies have been voluntarily 

submitted; these will be fully evaluated for the risk assessment portion of registration 

review.

Data Call-In Status:

Labels:

Registered products, including EPA registration numbers are provided in Table 1 below. For 

future reference, during registration review a list of product registration numbers will be included 

in the docket. Product registration labels may be obtained from the Pesticide Product Label 

System (PPLS) website at: http://oaspub.epa.gov/pestlabl/ppls.home.

Table 1. Registered Products – Bronopol
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Registration # Registration Name Company Name Formulation 

Type

% of Active 

Ingredient

464-675 BiobanTM BP-Plus 

Preservative The Dow Chemical Co. Ready-to-Use Solution 99

464-676 Bioban BP-40 

Preservative The Dow Chemical Co. Ready-to-Use Solution 40.8

464-680 Bioban BP-10 

Preservative The Dow Chemical Co. Ready-to-Use Solution 10

464-685 Bioban BP 30 

Preservative The Dow Chemical Co. Ready-to-Use Solution 30

464-687 Bioban BP-M 

Preservative The Dow Chemical Co. Technical Chemical 99

707-295 ROCIMATM 607 Rohm & Haas Co. Ready-to-Use 

Solution 10

707-315 ROCIMATM 586 Rohm & Haas Co. Soluble 

Concentrate 7.5

1258-1290 Proxel BN Preservative Arch Chemicals, Inc. Soluble 

Concentrate 6.5

1529-58 Nuosept W International Specialty 

Products 

Flowable 

Concentrate 7

1529-59 Nuosept W Concentrate International Specialty 

Products 

Soluble 

Concentrate 14

3876-147 S3876 DE-1220 GE Betz, Inc. Ready-to-Use 

Solution 5.3

3876-151 Betz® DE-5556 GE Betz, Inc. Ready-to-Use 

Solution 5.3

5383-106 Mergal K12N Troy Chemical Corp Ready-to-Use 

Solution 7.1

9386-45 AMA®-4900B Kemira Chemicals, Inc, Ready-to-Use 

Solution 10

10707-53 X-CIDE® 600 Industrial 

Microbiocide Baker Petrolite Corporation Water Soluble Packaging 98.45

33753-3 Myacide AS BASF Corporation Technical 

Chemical 99

33753-5 Myacide AS Plus BASF Corporation Crystalline 99

33753-7 Myacide S2 BASF Corporation Ready-to-Use 

Solution 40.8

33753-17 Myacide S15 BASF Corporation Ready-to-Use 

Solution 10
Docket Number: EPA-HQ-OPP-2011-0421

www.regulations.gov

18

Registration # Registration Name Company Name Formulation 

Type

% of Active 

Ingredient

33753-18 2K7 Bugstick BASF Corporation Pelleted/Tableted 84.5

33753-20 Myacide S30 BASF Corporation Ready-to-Use 

Solution 30

39967-28 Biochek 721M LANXESS Corporation Ready-to-Use 

Solution 6

39967-59 Preventol P 100 LANXESS Corporation Technical 

Chemical 99.74

39967-61 Preventol P 100 

Preservative LANXESS Corporation Soluble Concentrate 99.74

39967-64 Preventol P 30 LANXESS Corporation Soluble 

Concentrate 30

39967-79 Preventol P 91 LANXESS Corporation Emulsifiable 

Concentrate 9.97

49403-33 Nipacide GSF-A Clariant Corporation Ready-to-Use 

Solution 5.35

67071-16 Acticide LA Thor GmbH Ready-to-Use 

Solution 8.8

67071-18 Acticide SR 2060 Thor GmbH Ready-to-Use 

Solution 5.2

67071-45 Acticide MBL 5515 Thor GmbH Soluble 

Concentrate 15

67071-46 Acticide MBL Thor GmbH Ready-to-Use 

Solution 8

67071-50 Acticide LA 2605-F Thor GmbH Soluble 

Concentrate 5.3

67071-52 Acticide MBL 5505 Thor GmbH Soluble 

Concentrate 5

67212-1 BBJ Microbiocide BBJ Environmental, LLC Ready-to-Use 

Solution 95

67212-2 BBJ Maintain C-1 For 

Floors And Walls BBJ Environmental, LLC Soluble Concentrate 3.25

67212-3 BBJ Mold Control BBJ Environmental, LLC Ready-to-Use 

Solution .05

67420-1 2K7 Bugstick OSP Microcheck Inc Water Soluble 

Packaging 84.5

67420-2 2K7 Water Soluble Paks OSP Microcheck Inc Crystalline 99

67869-37 Vericide Bronopol Verichem, Inc. Crystalline 99
Docket Number: EPA-HQ-OPP-2011-0421

www.regulations.gov

19

Registration # Registration Name Company Name Formulation 

Type

% of Active 

Ingredient

67869-38 Vericide Bronopol 

Solution Verichem, Inc. Soluble Concentrate 10

68708-9 EC9086A Nalco Company Ready-to-Use 

Solution 8.8

74655-14 Spectrum RX-96 Hercules Incorporated Ready-to-Use 

Solution 5.3
Docket Number: EPA-HQ-OPP-2011-0421

www.regulations.gov

20

III. Summary of Anticipated Data Requirements – Bronopol

The table below summarizes anticipated data needs for the Bronopol case in Section I of this 

document (Preliminary Work Plan), Summary of Product Chemistry, Environmental Fate, and 

Ecotoxicity Data for the Bronopol Registration Review Decision Document, and 2-Bromo-2-

nitropropane-1,3-diol. Human Health Effects Scoping Document for the Registration Review 

Decision.

Table 2. Summary of Anticipated Data Requirements – Bronopol

Guideline

Number Anticipated Data Requirement Test Material

Estimated Timeframe 

(Measured in months from 

DCI Receipt)

*835.3110 Ready Biodegradability TGAI 24

*835.3220 Porous Pot Test TGAI 24

*835.3280

Simulation Tests to Assess the 

Biodegradability of Chemicals 

Discharged to Wastewater

TGAI 24

850.6800 Modified Activated Sludge Respiration 

Inhibition TGAI 12

850.1300 Daphnid Acute Toxicity TGAI 24

850.1400 Fish Early-Life Stage Toxicity TGAI 12

850.4225 Seedling Emergence, Tier II – dose 

response study on rice (Oryza sativa) TGAI 12

850.4250 Vegetative Vigor, Tier II – dose response 

study on rice (Oryza sativa) TGAI 12

850.4400

Aquatic Plant Growth (aquatic vascular 

plant toxicity, Tier II – dose response 

study on floating macrophyte Lemna 

gibba)

TGAI 12

850.5400

Aquatic Plant Growth (algal toxicity, Tier 

II – dose response studies on Selenastrum 

capricornutum (green alga), Anabaena 

flos- aquae (blue-green cyanobacteria), 

Navicula pelliculosa (freshwater diatom), 

and Skeletonema costatum (marine 

diatom).

TGAI 12

870.3465 90-Day Inhalation Toxicity (Rats) TGAI 24

875.1100 Dermal Exposure – Outdoor TGAI 24

875.1200 Dermal Exposure – Indoor TGAI 24

875.1300 Inhalation Exposure – Outdoor TGAI 24

875.1400 Inhalation Exposure – Indoor TGAI 24
Docket Number: EPA-HQ-OPP-2011-0421

www.regulations.gov

21

875.1600 Application Exposure Monitoring Data 

Reporting for Dermal and Inhalation Data TGAI 12

875.1700 Product Use Information – Outdoor TGAI 12

875.2700 Product Use Information – Indoor TGAI 12

875.2800 Description of Human Activity TGAI 12 

875.2900 Data Reporting and Calculations TGAI 24

* The results of the Activated Sludge Respiration Inhibition Test (ASRI) determine which of these biodegradation 

tests would be expected to be required. If the ASRI test EC50 is less than or equal to 20 mg/L, then either the 

Biodegradation in Activated Sludge Study or the Porous Pot Test would be expected to be required. If the ASRI test 

EC50 is greater than 20 mg/L, then the applicant would choose either: (i) Ready Biodegradability or (ii) 

Biodegradation in Activated Sludge or the Porous Pot Test. If the antimicrobial passes the ready biodegradability 

study, then no further testing would be expected to be required. If, however, the antimicrobial fails the ready 

biodegradability study, then the Biodegradation in Activated Sludge or the Porous Pot study would be expected to 

be required.
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 464-675

Soluble Concentrate 6.65

Medical Premises and Equipment

Medical Institutions, premises and equipment

Hard, inanimate, nonporous surfaces such as walls, floors, door handles, medical bed surfaces, bed frames, mattress springs, wheelchairs, light switches, linen carts, stretcher wheels, hampers, telephones, cleanup carts, bassinets, dressing 

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-675

Soluble Concentrate 6.65

Medical Premises and Equipment

Dental Premises and equipment

dental mixing spatulas, equipment trays, dental operating light fixtures and handles, instrument control panels, extra oral orthodontic headgears, orthodontic plastic brackets, and other non-critical, hard, nonporous, inanimate surfaces

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-675

Soluble Concentrate 6.65

Medical Premises and Equipment

Dental Premises and equipment

Ultrasonic cleaner concentrate Immersion 1/8 oz. per quart of 

water

216400 464-675

Soluble Concentrate 6.65

Medical Premises and Equipment

Hair Salons Nippers, brushes, combs, rollers, 

tweezers, razors, clipper blades, manicure, pedicure, and other implements commonly found in salons, including most plastics. 

Immersion 1/8 oz. per quart of 

water. 10 minute contact time.

Agricultural premises and equipment

Poultry Premises and Equipment

Floors, walls, and equipment, including incubators, hatchers, setters, trays, racks, carts, sexing tables, delivery trucks, troughs, rack, feeding and watering bins, buckets 

and fountains incubators Vehicles

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-675

Soluble Concentrate 6.65

and fountains. , incubators. Vehicles

including mats, crates, cabs and wheels.

216400 464-675

Soluble Concentrate 6.65

Agricultural premises and equipment

Poultry Premises and Equipment

Hatchery rooms Fog 1/2 gallon per 2.5 

gallons of water. Fog one minute for every 4000 cu. Ft.

Preclean premisDo not allow penot enter until pthoroughly.

216400 464-675

Soluble Concentrate 6.65

Agricultural premises and equipment

Poultry Premises and Equipment

Incubators and hatchers Fog 6 oz per 122 oz of 

water, fog 3-8 oz into setters and hatchers. Repeat daily in setters and every 12 hours in hatchers. Do not use for at least 24 hours 

1/2 oz per gallohourly or every Do not allow penot enter until pVentilate areas 

216400 464-675

Soluble Concentrate 6.65

Agricultural premises and equipment

Shoe Baths Entrances to buildings and livestock 

housing areas.

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-675

Soluble Concentrate 6.65

Residential and public access premises

day care facilities, schools, hotels, motels, restaurants,

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

1
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 464-675

Soluble Concentrate 6.65

Residential and public access premises

Dog and Cat Kennels Hard non porous areas, including, 

walls, floors and premises

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-675

Soluble Concentrate 6.65

Medical Premises and Equipment

Veterinary hospitals, clinics, premises and equipment

Instrument trays, operating tables, and other hard, nonporous premises and surfaces, including, walls and floors.

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-675

Soluble Concentrate 6.65

Agricultural premises and equipment

Cattle farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, crates, cabs and wheels. Halters, 

ropes and other types of equipment

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-675

Soluble Concentrate 6.65

Agricultural premises and equipment

Swine farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, 

crates cabs and wheels Halters

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-675

Soluble Concentrate 6.65

Agricultural premises and equipment

Horse Stables Hard non porous areas, including, 

walls, floors and premises

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-675

Soluble Concentrate 6.65

Agricultural premises and equipment

Farm premises and equipment

Hard non porous areas, including, walls, floors and premises

Fog 1 part to two parts 

water. Use one gallon per 6000-8000 cu. Ft.

Preclean premisDo not allow penot enter until pthoroughly.

216400 464-675

Soluble Concentrate 6.65

Agricultural premises and equipment

Greenhouses, aquaculture areas

Tools, equipment, potting areas, headhouses, dry storage areas, automated potting machinery and hard non porous areas, including, 

walls floors and premises

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

Agricultural 

premises and

Mushroom Houses Tools, equipment, breezeways, track 

alleys before spawning inside and

Spray, mop, wipe 1/2-1 oz. per gallon of 

water wet surface 10

216400 464-675

Soluble Concentrate 6.65

premises and

equipment

alleys before spawning, inside and

outside walls of mushroom houses, lofts, floors, storage sheds, spawning 

machines tampers and casing rings

water, wet surface. 10

minute contact time.

216400 464-476

Soluble Concentrate 5.32

Medical Premises and Equipment

Medical Institutions, premises and equipment

Hard, inanimate, nonporous surfaces such as walls, floors, door handles, medical bed surfaces, bed frames, mattress springs, wheelchairs, light switches, linen carts, stretcher wheels, hampers, telephones, cleanup carts, bassinets, dressing 

Spray, mop, wipe 1-2 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-476

Soluble Concentrate 5.32

Medical Premises and Equipment

Dental Premises and equipment

dental mixing spatulas, equipment trays, dental operating light fixtures and handles, instrument control panels, extra oral orthodontic headgears, orthodontic plastic brackets, and other non-critical, hard, nonporous, inanimate surfaces

Spray, mop, wipe 1-2 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-476

Soluble Concentrate 5.32

Medical Premises and Equipment

Hair Salons Nippers, brushes, combs, rollers, 

tweezers, razors, clipper blades, manicure, pedicure, and other implements commonly found in salons, including most plastics. 

Immersion 1/4 oz. per quart of 

water. 10 minute contact time.

2
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 464-476

Soluble Concentrate 5.32

Agricultural premises and equipment

Poultry Premises and Equipment

Floors, walls, and equipment, including incubators, hatchers, setters, trays, racks, carts, sexing tables, delivery trucks, troughs, rack, feeding and watering bins, buckets and fountains. , incubators. Vehicles including mats, crates, cabs and wheels.

Spray, mop, wipe 1-2 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-476

Soluble Concentrate 5.32

Residential and public access premises

day care facilities, schools, hotels, motels, restaurants

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1-2 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-476

Soluble Concentrate 5.32

Residential and public access premises

Dog and Cat Kennels Hard non porous areas, including, 

walls, floors and premises

Spray, mop, wipe 1-2 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-476

Soluble Concentrate 5.32

Medical Premises and Equipment

Veterinary hospitals, zoos, clinics, premises and equipment

Instrument trays, operating tables, and other hard, nonporous premises and surfaces, including, walls and floors.

Spray, mop, wipe 1-2 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-476

Soluble Concentrate 5.32

Agricultural premises and equipment

Cattle farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, 

crates cabs and wheels Halters

Spray, mop, wipe 1-2 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-476

Soluble Concentrate 5.32

Agricultural premises and equipment

Swine farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, 

crates cabs and wheels Halters

Spray, mop, wipe 1-2 oz. per gallon of 

water, wet surface. 10 minute contact time.

Medical Premises and Equipment

Medical Institutions, premises and equipment

Hard, inanimate, nonporous surfaces such as walls, floors, door handles, medical bed surfaces, bed frames, mattress springs, wheelchairs, light 

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-680

Soluble Concentrate 10.60

switches, linen carts, stretcher wheels, hampers, telephones, cleanup carts, bassinets, dressing 

216400 464-680

Soluble Concentrate 10.60

Medical Premises and Equipment

Dental Premises and equipment

dental mixing spatulas, equipment trays, dental operating light fixtures and handles, instrument control panels, extra oral orthodontic headgears, orthodontic plastic brackets, and other non-critical, hard, nonporous, inanimate surfaces

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-680

Soluble Concentrate 10.60

Agricultural premises and equipment

Poultry Premises and Equipment

Floors, walls, and equipment, including incubators, hatchers, setters, trays, racks, carts, sexing tables, delivery trucks, troughs, rack, feeding and watering bins, buckets and fountains. , incubators. Vehicles including mats, crates, cabs and wheels.

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-680

Soluble Concentrate 10.60

Residential and public access premises

day care facilities, schools, , hotels, motels, restaurants

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

3
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 464-680

Soluble Concentrate 10.60

Residential and public access premises

Dog and Cat Kennels Hard non porous areas, including, 

walls, floors and premises

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-680

Soluble Concentrate 10.60

Medical Premises and Equipment

Veterinary hospitals, clinics, premises and equipment

Instrument trays, operating tables, and other hard, nonporous premises and surfaces, including, walls and floors.

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-680

Soluble Concentrate 10.60

Agricultural premises and equipment

Cattle farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, 

crates cabs and wheels Halters

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 464-680

Soluble Concentrate 10.60

Agricultural premises and equipment

Swine farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, 

crates cabs and wheels Halters

Spray, mop, wipe 1/2-1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 675-19 

Soluble Concentrate 2.70

Medical Premises and Equipment

Medical Institutions, premises and equipment

Hard, inanimate, nonporous surfaces such as walls, floors, door handles, medical bed surfaces, bed frames, mattress springs, wheelchairs, light switches, linen carts, stretcher wheels, hampers, telephones, cleanup carts, bassinets, dressing 

Spray, mop, wipe 1/4-4 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 675-19 

Soluble Concentrate 2.70

Medical Premises and Equipment

Dental Premises and equipment

dental mixing spatulas, equipment trays, dental operating light fixtures and handles, instrument control panels, extra oral orthodontic headgears, orthodontic plastic brackets, and other non-critical, hard, nonporous, inanimate surfaces

Spray, mop, wipe 1/4-4 oz. per gallon of 

water, wet surface. 10 minute contact time.

Medical Premises 

and Equipment

Medical and Dental instruments

Surgical and dental instruments Immersion 1/4-4 oz. per gallon of 

water wet surface 15

216400 675-19 

Soluble Concentrate 2.70

and Equipment instruments water, wet surface. 15

minute contact time.

216400 675-19 

Soluble Concentrate 2.70

Medical Premises and Equipment

Human waste Urine, feces Pour 4 oz per gallon of 

water. One hour contact time.

216400 675-19 

Soluble Concentrate 2.70

Medical Premises and Equipment

Hospital Laundry Laundry, linens, blankets and diapers Pour 8 oz per 17 gallons of 

water and 10 pounds of laundry. Agitate for three minutes , soak for 10 minutes .

Pre-wash treatm

216400 675-43 

Soluble Concentrate 5.11

Medical Premises and Equipment

Medical Institutions, premises and equipment

Hard, inanimate, nonporous surfaces such as walls, floors, door handles, medical bed surfaces, bed frames, mattress springs, wheelchairs, light switches, linen carts, stretcher wheels, hampers, telephones, cleanup carts, bassinets, dressing 

Spray, mop, wipe 4 tsp- 1 1/3 oz per 

gallon of water, wet surface. 10 minute contact time.

4
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 675-43 

Soluble Concentrate 5.11

Medical Premises and Equipment

Dental Premises and equipment

dental mixing spatulas, equipment trays, dental operating light fixtures and handles, instrument control panels, extra oral orthodontic headgears, orthodontic plastic brackets, and other non-critical, hard, nonporous, inanimate surfaces

Spray, mop, wipe 4 tsp- 1 1/3 oz per 

gallon of water, wet surface. 10 minute contact time.

216400 675-43 

Soluble Concentrate 5.11

Medical Premises and Equipment

Medical and Dental instruments

Surgical and dental instruments Immersion 4 tsp to 1-1/3 oz per 

gallon of water, wet surface. 10 minute contact time.

216400 777-94 

Soluble Concentrate 5.50

Residential and public access premises

Household/domestic dwellings indoor premises

Hard, inanimate, nonporous surfaces such as Appliance Exteriors, Bathroom Surfaces, Bathtubs (Tub), Changing Tables (non-wood), Countertops, Cribs (non-wood), Diaper Pails (non-wood), Door Knobs 

(Handle), Enamel tile, Faucets,

Spray, mop, wipe 1-1/4 oz. per gallon of 

water, wet surface. 10 minute contact time.

Rinse all food c

216400 777-94 

Soluble Concentrate 5.50

Residential and public access premises

Household/domestic dwellings indoor premises

Toilet Bowl interiors pour 1/2 oz into toilet bowl 

water. 10 Minute contact time.

216400 777-94 

Soluble Concentrate 5.50

Medical Premises and Equipment

Hospital Laundry Laundry, linens, blankets and diapers Pour 8 oz per washload Pre-wash treatm

Medical Premises and Equipment

Medical Institutions, premises and equipment

Hard, inanimate, nonporous surfaces such as walls, floors, door handles, medical bed surfaces, bed frames, mattress springs, wheelchairs, light 

it h li t t t h

Spray, mop, wipe 1-1/4 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 777-94 

Soluble Concentrate 5.50

switches, linen carts, stretcher 

wheels, hampers, telephones, cleanup carts, bassinets, dressing 

216400 954-13 

Soluble Concentrate 4.75

Medical Premises and Equipment

Medical Institutions, premises and equipment

Hard, inanimate, nonporous surfaces such as walls, floors, door handles, medical bed surfaces, bed frames, mattress springs, wheelchairs, light switches, linen carts, stretcher wheels, hampers, telephones, cleanup carts, bassinets, dressing 

Spray, mop, wipe 1 oz. per 32 oz. of 

water, wet surface. 10 minute contact time. Allow to air dry.

216400 954-13 

Soluble Concentrate 4.75

Medical Premises and Equipment

Hair Salons Nippers, brushes, combs, rollers, 

tweezers, razors, clipper blades, manicure, pedicure, and other implements commonly found in salons, including most plastics. 

Immersion 1 oz. per 32 oz. of 

water, wet surface. 10 minute contact time. Allow to air dry.

216400 954-13 

Soluble Concentrate 4.75

Medical Premises and Equipment

Medical and Dental instruments

Surgical and dental instruments Immersion 1 oz. per 32 oz. of 

water, wet surface. 10 minute contact time. Allow to air dry.

5
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 1043-19 

Ready to use spray 0.077

Residential and public access premises

Air Treatments Schools, medical, dental and 

business offices, homes, sick rooms, nursing homes and general hospital areas.

Spray Spray upward to 

center of room for 3-5 seconds.

216400 1043-19 

Ready to use spray 0.077

Residential and public access premises

Day care facilities, schools, hotels, motels and business offices

Hard non porous areas, including, walls, floors and premises

Spray Hold 6-9 inches from 

surface and spray until wet, 2-3 seconds. 10 minutes 

contact time Allow to

216400 1043-19 

Ready to use spray 0.077

Medical Premises and Equipment

Medical Institutions, premises and equipment

Hard, inanimate, nonporous surfaces such as walls, floors, door handles, medical bed surfaces, bed frames, mattress springs, wheelchairs, light 

switches linen carts stretcher

Spray Hold 6-9 inches from 

surface and spray until wet, 2-3 seconds. 10 minutes 

contact time Allow to

216400 1043-26 

Soluble Concentrate 8.5

Agricultural premises and equipment

Cattle farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, 

crates cabs and wheels Halters

Spray, mop, wipe 1/2 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 1043-26 

Soluble Concentrate 8.5

Agricultural premises and equipment

Swine farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, 

crates cabs and wheels Halters

Spray, mop, wipe 1/2 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 1043-26 

Soluble Concentrate 8.5

Agricultural premises and equipment

Poultry Premises and Equipment

Floors, walls, and equipment, including incubators, hatchers, setters, trays, racks, carts, sexing tables, delivery trucks, troughs, rack, feeding and watering bins, buckets and fountains. , incubators. Vehicles including mats, crates, cabs and wheels.

Spray, mop, wipe 1/2 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 1043 26

Soluble Concentrate 8 5

Agricultural premises and equipment

Mushroom Houses Tools, equipment, breezeways, track 

alleys before spawning, inside and outside walls of mushroom houses, lofts, floors, storage sheds, spawning

Spray, mop, wipe 1/2 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 1043-26 Concentrate 8.5 g pg machines tampers and casing rings216400 1043-26 

Soluble Concentrate 8.5

Agricultural premises and equipment

Agricultural premises Food contact surfaces, tools, and 

equipment

Spray, mop, wipe 1/2 oz. per gallon of 

water, wet surface. 10 minute contact time.

Rinse all food c

216400 1043-26 

Soluble Concentrate 8.5

Agricultural premises and equipment

Poultry Premises and Equipment

Hatchery rooms Fog 1/2 gallon per gallon 

of water. Use 32-64 oz of prepared solution per 1000 cu 

ft

Preclean premisDo not allow penot enter until pthoroughly.

216400 303-223 

Soluble Concentrate 5.32

Medical Premises and Equipment

Veterinary hospitals, zoos, clinics, premises and equipment

Instrument trays, operating tables, and other hard, nonporous premises and surfaces, including, walls and floors.

Fog 1/2 gallon per gallon 

of water. Use 32-64 oz of prepared solution per 1000 cu 

ft

Preclean premisDo not allow penot enter until pthoroughly.

216400 1043-26 

Soluble Concentrate 8.5

Agricultural premises and equipment

Farm premises and equipment

Hard non porous areas, including, walls, floors and premises

Fog 1/2 gallon per gallon 

of water. Use 32-64 oz of prepared solution per 1000 cu 

ft

Preclean premisDo not allow penot enter until pthoroughly.

216400 1043-118 

Soluble Concentrate 6.4

Commercial, institutional and industrial premises

Commercial and institutional floors and premises

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

6
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 1043-118 

Soluble Concentrate 6.4

Medical Premises and Equipment

Veterinary hospitals, clinics, premises and equipment

Instrument trays, operating tables, and other hard, nonporous premises and surfaces, including, walls and floors.

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 1043-118 

Soluble Concentrate 6.4

Residential and public access premises

Day care facilities, schools, hotels, motels and business offices

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 1677-128 

Soluble Concentrate 1.4

Food handling processing equipment and premises

Beverage, food and dairy processing equipment 

Conveyor belts Metered spray 1 1/4 oz per gallon of 

water (1% by volume) 5 minute contact time

216400 2212-17 

Soluble Concentrate 3.8

Medical Premises and Equipment

Ultrasonic cleaners Non-porous instruments or appliances Immersion Prepare a solution of 

1 oz per gallon of water. Add recommended amount to cleaner. 10 minute run cycle. 

216400 2212-17 

Soluble Concentrate 3.8

Medical Premises and Equipment

Hospital semi-critical items Precleaning of Non-porous 

instruments or appliances prior to terminal sterilization

Immersion 1 oz per gallon of 

water, 10 minutes contact time. Thoroughly rinse items before sterilization.

216400 2212-17 

Soluble Concentrate 3.8

Commercial, institutional and industrial premises and equipment

walls, floors and other inanimate hard, nonporous surfaces

walls, floors, furniture, shower/bathing areas, lavatories and other hard nonporous inanimate surfaces

Spray, mop, wipe 1 oz per gallon of 

water, 10 minutes contact time.

Soluble

Medical Premises and Equipment

Hospital and medical institutions non-critical premises and equipment`

walls, floors, furniture, shower/bathing areas, lavatories and other hard nonporous inanimate surfaces

Spray, mop, wipe 1 oz per gallon of 

water, 10 minutes contact time.

216400 2212-17 

Soluble

Concentrate 3.8

216400 2296-102 

Soluble Concentrate 3.6

Medical Premises and Equipment

Hospital and medical institutions non-critical premises and equipment`

walls, floors, furniture, shower/bathing areas, lavatories and other hard nonporous inanimate surfaces

Spray, mop, wipe 3.5 Tbs per gallon of 

water, 10 minute contact time.

216400 2296-102 

Soluble Concentrate 3.6

Residential and public access premises

Toilet Bowls Hard, nonporous toilet bowl interiors Spray, wipe 3.5 Tbs per gallon of 

water, 10 minute contact time.

216400 2296-102 

Soluble Concentrate 3.6

Residential and public access premises

Garbage receptacles Garbage pails and receptacles Spray 4 Tbs per gallon of 

water. Rinse empty can with solution.

216400 2296-102 

Soluble Concentrate 3.6

Agricultural premises and equipment

Farm premises and equipment

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 3.5 Tbs per gallon of 

water, 10 minute contact time.

7
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 2296-102 

Soluble Concentrate 3.6

Agricultural premises and equipment

Poultry Premises and Equipment

Floors, walls, and equipment, including incubators, hatchers, setters, trays, racks, carts, sexing tables, delivery trucks, troughs, rack, feeding and watering bins, buckets and fountains. , incubators. Vehicles including mats, crates, cabs and wheels.

Spray, mop, wipe 3.5 Tbs per gallon of 

water, 10 minute contact time.

216400 2296-105 

Soluble Concentrate 2.0

Residential and public access premises

Hotels, apartment buildings, households, motels, schools and office buildings

Toilets, urinals, lavatories, shower stalls, floors, walls,

Spray, mop, wipe 2-8 oz. per gallon of 

water, 10 minute contact time.

216400 2296-105 

Soluble Concentrate 2.0

Commercial , institutional, and industrial premises

Industrial plants Toilets, urinals, lavatories, shower 

stalls, floors, walls, 

Spray, mop, wipe 2 oz. per gallon of 

water, 10 minute contact time.

216400 2296-105 

Soluble Concentrate 2.0

Residential and public access premises

Toilet Bowls Hard, nonporous toilet bowl interiors Spray, wipe 2 oz. per gallon of 

water, 10 minute contact time.

216400 3862-177 

Soluble Concentrate 10.0

Medical Premises and Equipment

Hospital and medical institutions non-critical premises and equipment`

walls, floors, furniture, shower/bathing areas, lavatories and other hard nonporous inanimate surfaces

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time.

Agricultural premises and equipment

Poultry Premises and Equipment

Floors, walls, and equipment, including incubators, hatchers, setters, trays, racks, carts, sexing 

t bl d li t k t h k

Spray, mop, wipe, fog 1/2 oz. per gallon of 

water, 10 minute contact time. 

For fog applicatventilation befor

216400 3862-177 

Soluble Concentrate 10.0

tables, delivery trucks, troughs, rack, 

feeding and watering bins, buckets and fountains. , incubators. Vehicles including mats, crates, cabs and wheels.

216400 3862-177 

Soluble Concentrate 10.0

Agricultural premises and equipment

Cattle farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, crates, cabs and wheels. Halters, ropes, and other types of equipment used in handling and restraining animals

Spray, mop, wipe, fog 1/2 oz. per gallon of 

water, 10 minute contact time.

Do not use in mapplications alloventilation befor

216400 3862-177 

Soluble Concentrate 10.0

Agricultural premises and equipment

Swine farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, crates, cabs and wheels. Halters, ropes, and other types of equipment used in handling and restraining 

animals

Spray, mop, wipe, fog 1/2 oz. per gallon of 

water, 10 minute contact time.

Do not use in mapplications alloventilation befor

216400 3862-177 

Soluble Concentrate 10.0

Agricultural premises and equipment

Horse Stables Hard non porous areas, including, 

walls, floors and premises

Spray, mop, wipe, fog 1/2 oz. per gallon of 

water, 10 minute contact time.

For fog applicatventilation befor

8
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 3862-177 

Soluble Concentrate 10.0

Agricultural premises and equipment

Poultry Premises and Equipment

Hatchery rooms, hatching egg sanitizer.

Automatic washing systems, immersion tanks, foaming apparatus, LP sprayers and fogging

1/2 oz. per gallon of water.

216400 3862-177 

Soluble Concentrate 10.0

Agricultural premises and equipment

Poultry Premises and Equipment

Bird cages Spray, wipe 1/2 oz. per gallon of 

water, 10 minute contact time.

216400 3862-178 

Soluble Concentrate 6.5

Medical Premises and Equipment

Hospital and medical institutions non-critical premises and equipment`

walls, floors, furniture, shower/bathing areas, lavatories and other hard nonporous inanimate surfaces

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time.

216400 3862-178 

Soluble Concentrate 6.5

Agricultural premises and equipment

Poultry Premises and Equipment

Floors, walls, and equipment, including incubators, hatchers, setters, trays, racks, carts, sexing tables, delivery trucks, troughs, rack, 

feeding and watering bins buckets

Spray, mop, wipe, fog 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 3862-178 

Soluble Concentrate 6.5

Agricultural premises and equipment

Farm premises and equipment

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 3862-179 

Soluble Concentrate 3.0

Medical Premises and Equipment

Hospital and medical institutions non-critical premises and equipment`

walls, floors, furniture, shower/bathing areas, lavatories and other hard nonporous inanimate surfaces

Spray, mop, wipe, fog 1 oz. per gallon of 

water, 10 minute contact time. 

216400 3862-179 

Soluble Concentrate 3.0

Agricultural premises and equipment

Poultry Premises and Equipment

Floors, walls, and equipment, including incubators, hatchers, setters, trays, racks, carts, sexing tables, delivery trucks, troughs, rack, feeding and watering bins, buckets 

and fountains incubators Vehicles

Spray, mop, wipe, fog 1 oz. per gallon of 

water, 10 minute contact time. For fog uses, add solution to approved timed 

fogger 6 min per

For fog applicatbefore reentry

and fountains incubators Vehicles

216400 3862-179 

Soluble Concentrate 3.0

Agricultural premises and equipment

Farm premises and equipment

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe, fog 1 oz. per gallon of 

water, 10 minute contact time. For fog uses, add solution to approved timed fogger, 6 min per 

For fog applicatbefore reentry

216400 3862-180 

Soluble Concentrate 5.06

Residential and public access premises

Hotels, apartment buildings, households, motels, schools and office buildings

walls, floors, furniture, shower/bathing fixtures, drinking fountains, sinks, refrigerators, stoves, and other hard non-porous inanimate surfaces

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 3862-180 

Soluble Concentrate 5.06

Commercial , institutional, and industrial premises

Industrial plants walls, floors, furniture, shower/bathing 

fixtures, drinking fountains, sinks, refrigerators, stoves, and other hard non-porous inanimate surfaces

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 3862-180 

Soluble Concentrate 5.06

Residential and public access premises

Garbage receptacles Garbage pails and receptacles Spray 1/2 oz. per gallon of 

water, 10 minute contact time. 

9
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 3862-180 

Soluble Concentrate 5.06

Agricultural premises and equipment

Swine farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, crates, cabs and wheels. Halters, ropes, and other types of equipment used in handling and restraining 

Spray, mop, wipe, fog 1/2 oz. per gallon of 

water, 10 minute contact time. For fog uses, add solution to approved timed fogger, 3 min per 2000 cu. Ft.

For fog applicatbefore reentry

216400 3862-180 

Soluble Concentrate 5.06

Agricultural premises and equipment

Poultry Premises and Equipment

Floors, walls, and equipment, including incubators, hatchers, setters, trays, racks, carts, sexing tables, delivery trucks, troughs, rack, feeding and watering bins, buckets and fountains. , incubators. Vehicles including mats, crates, cabs and 

wheels

Spray, mop, wipe, fog 1/2 oz. per gallon of 

water, 10 minute contact time. For fog uses, add solution to approved timed fogger, 3 min per 2000 cu. Ft.

For fog applicatbefore reentry

216400 3862-180 

Soluble Concentrate 5.06

Agricultural premises and equipment

Farm premises and equipment

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe, fog 1/2 oz. per gallon of 

water, 10 minute contact time. For fog uses, add solution to approved timed fogger, 3 min per 2000 cu. Ft.

For fog applicatbefore reentry

216400 3862-180 

Soluble Concentrate 5.06

Medical Premises and Equipment

Barber/beauty shop instruments.

Combs, brushes, razors, scissors Wipe, immersion 1/2 oz. per gallon of 

water, 10 minute contact time. 

Pressurized

Residential and public access premises

Hotels, apartment buildings, households, motels, schools and office buildings

walls, floors, furniture, shower/bathing fixtures, drinking fountains, sinks, refrigerators, stoves, and other hard non-porous inanimate surfaces

Spray Hold 6-8 inches from 

surface and spray until wet, 2-3 seconds. 10 minutes contact time. Allow to 

air dry

216400 5741-22 

PressurizedLiquid 0.071

air dry.

216400 5741-22 

Pressurized Liquid 0.071

Commercial , institutional, and industrial premises

Industrial plants walls, floors, furniture, shower/bathing 

fixtures, drinking fountains, sinks, refrigerators, stoves, and other hard non-porous inanimate surfaces

Spray Hold 6-8 inches from 

surface and spray until wet, 2-3 seconds. 10 minutes contact time. Allow to air dry.

216400 6836-252 

Soluble Concentrate 9.5

Medical Premises and Equipment

Medical Institutions, premises and equipment

Use on hard, nonporous surfaces such as floors, walls, metal surfaces, painted surfaces, exterior bowl surfaces, empty basins, showers, conductive flooring and lavatory fixtures.

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 6836-252 

Soluble Concentrate 9.5

Medical Premises and Equipment

Dental Premises and equipment

Use on hard, nonporous surfaces such as floors, walls, metal surfaces, painted surfaces, exterior bowl surfaces, empty basins, showers, conductive flooring and lavatory fixtures.

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

10
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 6836-252 

Soluble Concentrate 9.5

Agricultural premises and equipment

Poultry Premises and Equipment

Floors, walls, and equipment, including incubators, hatchers, setters, trays, racks, carts, sexing tables, delivery trucks, troughs, rack, feeding and watering bins, buckets and fountains. , incubators. Vehicles including mats, crates, cabs and wheels.

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 6836-252 

Soluble Concentrate 9.5

Agricultural premises and equipment

Poultry Premises and Equipment

Hatchery rooms, Incubators and hatchers

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 6836-252 

Soluble Concentrate 9.5

Food handling processing equipment and premises

Meat and poultry processing plants

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

Food products aremoved from thproduct in accomust be thoroug

216400 6836-252 

Soluble Concentrate 9.5

Agricultural premises and equipment

Shoe Baths Entrances to buildings and livestock 

housing areas.

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 6836-252 

Soluble Concentrate 9.5

Residential and public access 

premises

Day care facilities, schools, hotels, motels, restaurants

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 6836-252 

Soluble Concentrate 9.5

Residential and public access premises

Dog and Cat Kennels Hard non porous areas, including, 

walls, floors and premises

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 6836-252 

Soluble Concentrate 9.5

Medical Premises and Equipment

Veterinary hospitals, clinics, premises and equipment

Instrument trays, operating tables, and other hard, nonporous premises and surfaces, including, walls and floors.

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

Agricultural premises and equipment

Cattle farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, crates, cabs and wheels. Halters,

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 6836-252 

Soluble Concentrate 9.5

, ,

ropes, and other types of equipment used in handling and restraining animals

216400 6836-252 

Soluble Concentrate 9.5

Agricultural premises and equipment

Swine farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, crates, cabs and wheels. Halters, ropes, and other types of equipment used in handling and restraining animals

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 6836-252 

Soluble Concentrate 9.5

Agricultural premises and equipment

Horse Stables Hard non porous areas, including, 

walls, floors and premises

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 6836-253 

Soluble Concentrate 4.75

Medical Premises and Equipment

Medical Institutions, premises and equipment

Use on hard, nonporous surfaces such as floors, walls, metal surfaces, painted surfaces, exterior bowl surfaces, empty basins, showers, conductive flooring and lavatory fixtures.

Spray, mop, wipe 1 oz. per gallon of 

water, 10 minute contact time. 

11
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 6836-253 

Soluble Concentrate 4.75

Medical Premises and Equipment

Dental Premises and equipment

Use on hard, nonporous surfaces such as floors, walls, metal surfaces, painted surfaces, exterior bowl surfaces, empty basins, showers, conductive flooring and lavatory fixtures.

Spray, mop, wipe 1 oz. per gallon of 

water, 10 minute contact time. 

216400 6836-253 

Soluble Concentrate 4.75

Agricultural premises and equipment

Poultry Premises and Equipment

Floors, walls, and equipment, including incubators, hatchers, setters, trays, racks, carts, sexing tables, delivery trucks, troughs, rack, feeding and watering bins, buckets and fountains. , incubators. Vehicles including mats, crates, cabs and wheels.

Spray, mop, wipe 1 oz. per gallon of 

water, 10 minute contact time. 

216400 6836-253 

Soluble Concentrate 4.75

Food handling processing equipment and premises

Meat and poultry processing plants

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1 oz. per gallon of 

water, 10 minute contact time. 

Food products aremoved from thproduct in accomust be thoroug

216400 6836-253 

Soluble Concentrate 4.75

Residential and public access premises

Toilet Bowls Hard, nonporous toilet bowl interiors Spray, wipe 1 oz. per gallon of 

water, 10 minute contact time. 

216400 6836-253 

Soluble Concentrate 4.75

Agricultural premises and equipment

Poultry Premises and Equipment

Hatchery rooms, Incubators and hatchers

Spray, mop, wipe 1 oz. per gallon of 

water, 10 minute contact time. 

216400 6836-253 

Soluble Concentrate 4.75

Agricultural premises and equipment

Shoe Baths Entrances to buildings and livestock 

housing areas.

Spray, mop, wipe 1 oz. per gallon of 

water, 10 minute contact time. 

216400 6836-253 

Soluble Concentrate 4.75

Residential and public access 

premises

Day care facilities, schools, hotels, motels, restaurants

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1 oz. per gallon of 

water, 10 minute contact time. 

Residential and Dog and Cat Kennels Hard non porous areas, including, Spray, mop, wipe 1 oz. per gallon of 

216400 6836-253 

Soluble Concentrate 4.75

public access premises

walls, floors and premises water, 10 minute 

contact time. 

216400 6836-253 

Soluble Concentrate 4.75

Medical Premises and Equipment

Veterinary hospitals, clinics, pet shops, premises and equipment

Instrument trays, operating tables, and other hard, nonporous premises and surfaces, including, walls and floors.

Spray, mop, wipe 1 oz. per gallon of 

water, 10 minute contact time. 

216400 6836-253 

Soluble Concentrate 4.75

Agricultural premises and equipment

Cattle farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, crates, cabs and wheels. Halters, ropes, and other types of equipment used in handling and restraining animals

Spray, mop, wipe 1 oz. per gallon of 

water, 10 minute contact time. 

216400 6836-253 

Soluble Concentrate 4.75

Agricultural premises and equipment

Swine farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, crates, cabs and wheels. Halters, ropes, and other types of equipment used in handling and restraining animals

Spray, mop, wipe 1 oz. per gallon of 

water, 10 minute contact time. 

12
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 6836-253 

Soluble Concentrate 4.75

Agricultural premises and equipment

Horse Stables Hard non porous areas, including, 

walls, floors and premises

Spray, mop, wipe 1 oz. per gallon of 

water, 10 minute contact time. 

216400 33176-6 

Pressurized Liquid 0.08

Medical Premises and Equipment

Hospital semi-critical items Precleaning of Non-porous 

instruments or appliances prior to terminal sterilization

Spray Spray until surface is 

wet, allow to air dry/10 minute contact time.

216400 33176-6 

Pressurized Liquid 0.08

Residential and public access premises

Hotels, apartment buildings, households, motels, schools and office buildings

walls, woodwork, cabinets, floors, files, wash basins, bathtubs, toilet seats, venetian blinds, chrome and stainless steel, stoves, canopies, exterior of refrigerators and freezers, sinks, appliances, porcelain, ceramic, counter and table tops.

Spray Spray until surface is 

wet, allow to air dry/10 minute contact time.

216400 33176-6 

Pressurized Liquid 0.08

Medical Premises and Equipment

Hospital and medical institutions non-critical premises and equipment`

walls, woodwork, cabinets, floors, files, wash basins, bathtubs, toilet seats, venetian blinds, chrome and stainless steel, stoves, canopies, exterior of refrigerators and freezers, sinks, appliances, porcelain, ceramic, counter and table tops.

Spray Spray until surface is 

wet, allow to air dry/10 minute contact time.

216400 34810-8 

Soluble Concentrate 5.76

Residential and public access premises

Schools and office buildings Hard non porous areas, including, 

walls, floors and premises

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

Medical Premises 

and Equipment

Hospital and medical institutions non critical

Hard non porous areas, including, walls floors and premises

Spray, mop, wipe 1/2 oz. per gallon of 

water 10 minute

216400 34810-8 

Soluble Concentrate 5.76

and Equipment institutions non-critical

premises and equipment`

walls, floors and premises water, 10 minute 

contact time. 

216400 34810-8 

Soluble Concentrate 5.76

Food handling processing equipment and premises

Meat and poultry processing plants

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

Food products aremoved from thproduct in accomust be thoroug

216400 34810-21 

Ready to use solution 0.023

Residential and public access premises

Athletic Facilities, Police facilities

Hard, nonporous inanimate surfaces: floors, walls, metal surfaces, stainless steel surfaces, glazed porcelain, plastic surfaces.

Spray, mop, wipe Wet surfaces 

thoroughly, 10 minute contact time

216400 34810-21 

Ready to use solution 0.023

Medical Premises and Equipment

Operating Rooms, Intensive Care, Nurseries, Emergency Areas, Dental Operatories.

Hard, nonporous inanimate surfaces: floors, walls, metal surfaces, stainless steel surfaces, glazed porcelain, plastic surfaces.

Spray, mop, wipe Wet surfaces 

thoroughly, 10 minute contact time

13
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 34810-21 

Ready to use solution 0.023

Medical Premises and Equipment

Hospital semi-critical items Precleaning of Non-porous 

instruments or appliances prior to terminal sterilization

Immersion Wet surfaces 

thoroughly, 10 minute contact time

216400 34810-31 

Soluble Concentrate 3.03

Medical Premises and Equipment

Medical Institutions, premises and equipment

Hard non porous areas, including, walls, bathroom fixtures, stainless steel, chrome, glass and vinyl.

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 34810-31 

Soluble Concentrate 3.03

Medical Premises and Equipment

Dental Premises and equipment

Hard non porous areas, including, walls, bathroom fixtures, stainless steel, chrome, glass and vinyl.

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 34810-31 

Soluble Concentrate 3.03

Medical Premises and Equipment

Whirlpool baths and foot spas

Hard non porous surfaces in whirlpool bath and foot spa units

circulation, mop, wipe 1 oz. per gallon of 

water. Drain unit and fill with prepared solution, run pump for 10 minutes. Drain, rinse and allow to air dry.

216400 34810-31 

Soluble Concentrate 3.03

Medical Premises and Equipment

Hair Salons Nippers, brushes, combs, rollers, 

tweezers, razors, clipper blades, manicure, pedicure, and other implements commonly found in salons, including most plastics. 

Immersion 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 34810 31

Soluble Concentrate 3 03

Agricultural premises and equipment

Farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, crates, cabs and wheels. Halters, 

ropes and other types of equipment

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 34810-31 Concentrate 3.03 ropes, and other types of equipment

216400 34810-31 

Soluble Concentrate 3.03

Agricultural premises and equipment

Poultry Premises and Equipment

Floors, walls, and equipment, including incubators, hatchers, setters, trays, racks, carts, sexing tables, delivery trucks, troughs, rack, feeding and watering bins, buckets and fountains. , incubators. Vehicles including mats, crates, cabs and wheels.

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 34810-31 

Soluble Concentrate 3.03

Residential and public access premises

day care facilities, schools, hotels, motels, restaurants,

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 34810-31 

Soluble Concentrate 3.03

Medical Premises and Equipment

Veterinary hospitals, clinics, premises and equipment

Instrument trays, operating tables, and other hard, nonporous premises and surfaces, including, walls and floors.

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 39967-5 

Technical Chemical 98.6

For manufacturing use only

14
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 39967-6 

Formulation Intermediate 75.0

For manufacturing use only

216400 39967-81 

Soluble Concentrate 5.0

Commercial , institutional, and industrial premises

Commercial transportation facilities

Transportation equipment Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 39967-81 

Soluble Concentrate 5.0

Residential and public access premises

Animal kennels Animal cages and holding areas Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 39967-81 

Soluble Concentrate 5.0

Medical Premises and Equipment

Veterinary hospitals, clinics, premises and equipment

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 39967-81 

Soluble Concentrate 5.0

Medical Premises and Equipment

Medical Institutions, premises and equipment

walls, woodwork, cabinets, floors, files, wash basins, bathtubs, toilet seats, venetian blinds, chrome and stainless steel, stoves, canopies, exterior of refrigerators and freezers, sinks, appliances, porcelain, ceramic, 

counter and table tops

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 39967-81 

Soluble Concentrate 5.0

Agricultural premises and equipment

Farm premises and equipment

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 39967-81 

Soluble Concentrate 5.0

Medical Premises and Equipment

Hospital and medical institutions non-critical premises and equipment`

Conductive flooring in operating rooms.

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

Medical Premises Medical Institutions, walls, woodwork, cabinets, floors, Spray, mop, wipe 1/2 oz. per gallon of 

216400 39967-83 

Soluble Concentrate 10.0

Medical Premises

and Equipment

Medical Institutions,

premises and equipment

walls, woodwork, cabinets, floors,

files, wash basins, bathtubs, toilet seats, venetian blinds, chrome and stainless steel, stoves, canopies, exterior of refrigerators and freezers, sinks, appliances, porcelain, ceramic, 

Spray, mop, wipe 1/2 oz. per gallon of

water, 10 minute contact time. 

216400 39967-83 

Soluble Concentrate 10.0

Medical Premises and Equipment

Hospital semi-critical items Precleaning of Non-porous 

instruments or appliances prior to terminal sterilization

Spray, immersion 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 39967-83 

Soluble Concentrate 10.0

Agricultural premises and equipment

Farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, crates, cabs and wheels. Halters, ropes, and other types of equipment used in handling and restraining animals

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

15
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 39967-83 

Soluble Concentrate 10.0

Agricultural premises and equipment

Poultry Premises and Equipment

Floors, walls, and equipment, including incubators, hatchers, setters, trays, racks, carts, sexing tables, delivery trucks, troughs, rack, feeding and watering bins, buckets and fountains. , incubators. Vehicles including mats, crates, cabs and wheels.

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 46851-1 

Soluble Concentrate 1.0

Medical Premises and Equipment

Hospital semi-critical items Precleaning of Non-porous 

instruments or appliances prior to terminal sterilization

Spray, immersion Add 4 oz to 124 oz of 

water, 10 minute contact time

216400 46851-1 

Soluble Concentrate 1.0

Medical Premises and Equipment

Ultrasonic cleaners Non-porous instruments or appliances Immersion add 4 oz to 124 oz of 

water. Add recommended amount of made up 

solution to device

216400 46851-1 

Soluble Concentrate 1.0

Medical Premises and Equipment

Medical Institutions, premises and equipment

Use on hard, nonporous surfaces such as floors, walls, metal surfaces, painted surfaces, exterior bowl surfaces, empty basins, showers, 

and lavatory fixtures

Spray, mop, wipe Add 4 oz to 124 oz of 

water, 10 minute contact time

216400 46851-1 

Soluble Concentrate 1.0

Medical Premises and Equipment

Veterinary hospitals, clinics, premises and equipment

Use on hard, nonporous surfaces such as floors, walls, metal surfaces, painted surfaces, exterior bowl surfaces, empty basins, showers, 

and lavatory fixtures

Spray, mop, wipe Add 4 oz to 124 oz of 

water, 10 minute contact time

216400 46851-1 

Soluble Concentrate 1.0

Medical Premises and Equipment

Dental Premises and equipment

Use on hard, nonporous surfaces such as floors, walls, metal surfaces, painted surfaces, exterior bowl surfaces, empty basins, showers, and lavatory fixtures.

Spray, mop, wipe Add 4 oz to 124 oz of 

water, 10 minute contact time

Medical Premises Medical Institutions Hard non porous areas including Spray mop wipe Thoroughly wet

216400 46851-5 

Ready to use solution 0.03

Medical Premises

and Equipment

Medical Institutions, 

premises and equipment

Hard non porous areas, including, 

walls, floors and premises

Spray, mop, wipe Thoroughly wet

surface, 10 minute contact time.

216400 46851-5 

Ready to use solution 0.03

Medical Premises and Equipment

Veterinary hospitals, clinics, premises and equipment

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe Thoroughly wet 

surface, 10 minute contact time.

216400 46851-5 

Ready to use solution 0.03

Medical Premises and Equipment

Dental Premises and equipment

Use on hard, nonporous surfaces such as floors, walls, metal surfaces, painted surfaces, exterior bowl surfaces, empty basins, showers, 

and lavatory fixtures

Spray, mop, wipe Thoroughly wet 

surface, 10 minute contact time.

216400 46851-10 

Impregnated Materials 0.03

Medical Premises and Equipment

Medical Institutions, premises and equipment

Use on hard, nonporous surfaces such as floors, walls, metal surfaces, painted surfaces, exterior bowl surfaces, empty basins, showers, 

and lavatory fixtures

Wipe Thoroughly wet 

surface, 10 minute contact time.

216400 46851-10 

Impregnated Materials 0.03

Medical Premises and Equipment

Veterinary hospitals, clinics, premises and equipment

Use on hard, nonporous surfaces such as floors, walls, metal surfaces, painted surfaces, exterior bowl surfaces, empty basins, showers, 

and lavatory fixtures

Wipe Thoroughly wet 

surface, 10 minute contact time.

16
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 46851-10 

Impregnated Materials 0.03

Medical Premises and Equipment

Dental Premises and equipment

Use on hard, nonporous surfaces such as floors, walls, metal surfaces, painted surfaces, exterior bowl surfaces, empty basins, showers, 

and lavatory fixtures

Wipe Thoroughly wet 

surface, 10 minute contact time.

216400 46851-10 

Impregnated Materials 0.03

Commercial , institutional, and industrial premises

Commercial transportation vehicles

Ambulances, boats, autos, police vehicles

Wipe Thoroughly wet 

surface, 10 minute contact time.

216400 46851-10 

Impregnated Materials 0.03

Residential and public access premises

Bathrooms Hard non porous areas, including, 

walls, floors and premises

Wipe Thoroughly wet 

surface, 10 minute contact time.

216400 46851-10 

Impregnated Materials 0.03

Residential and public access premises

Household and domestic dwellings

Hard non porous areas, including, walls, floors and premises

Wipe Thoroughly wet 

surface, 10 minute contact time.

216400 46851-10 

Impregnated Materials 0.03

Residential and public access premises

Schools, grocery stores, shopping centers, hotels

Hard non porous areas, including, walls, floors and premises

Wipe Thoroughly wet 

surface, 10 minute contact time.

216400 61282-53 

Soluble Concentrate 9.97

Medical Premises and Equipment

Medical Institutions, premises and equipment

Hard, inanimate, nonporous surfaces such as walls, floors, door handles, medical bed surfaces, bed frames, mattress springs, wheelchairs, light switches, linen carts, stretcher wheels, hampers, telephones, cleanup carts, bassinets, dressing 

Spray, mop, wipe 1/2-1 1/2 oz. per 

gallon of water, wet surface. 10 minute contact time.

Agricultural premises and equipment

Poultry Premises and Equipment

Floors, walls, and equipment, including incubators, hatchers, setters, trays, racks, carts, sexing tables, delivery trucks, troughs, rack, 

Spray, mop, wipe 1/2-1 1/2 oz. per 

gallon of water, wet surface. 10 minute contact time.

216400 61282-53 

Soluble Concentrate 9.97

feeding and watering bins, buckets and fountains. , incubators. Vehicles including mats, crates, cabs and wheels.

216400 61282-53 

Soluble Concentrate 9.97

Agricultural premises and equipment

Poultry Premises and Equipment

Hatchery rooms Fog 1/2 gallon to 2.5 

gallons water in approved fogger appliance. One 

minute per 4 000 cu

Preclean premisDo not allow penot enter until pthoroughly.

216400 61282-53 

Soluble Concentrate 9.97

Agricultural premises and equipment

Poultry Premises and Equipment

Incubators and hatchers Fog 6 oz per 122 oz of 

water, fog 3-8 oz into setters and hatchers. Repeat daily in setters and every 12 hours in hatchers. Do not use for at least 24 hours 

1/2 oz per gallohourly or every Do not allow penot enter until pVentilate areas 

216400 61282-53 

Soluble Concentrate 9.97

Agricultural premises and equipment

Shoe Baths Entrances to buildings and livestock 

housing areas.

Spray, mop, wipe 1/2-1 1/2 oz. per 

gallon of water, wet surface. 10 minute contact time.

17
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 61282-53 

Soluble Concentrate 9.97

Residential and public access premises

day care facilities, schools, hotels, motels, restaurants,

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1/2-1 1/2 oz. per 

gallon of water, wet surface. 10 minute contact time.

216400 61282-53 

Soluble Concentrate 9.97

Medical Premises and Equipment

Veterinary hospitals, clinics, premises and equipment

Instrument trays, operating tables, and other hard, nonporous premises and surfaces, including, walls and floors.

Spray, mop, wipe 1/2-1 1/2 oz. per 

gallon of water, wet surface. 10 minute contact time.

216400 61282-53 

Soluble Concentrate 9.97

Agricultural premises and equipment

Cattle farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, crates, cabs and wheels. Halters, 

ropes and other types of equipment

Spray, mop, wipe 1/2-1 1/2 oz. per 

gallon of water, wet surface. 10 minute contact time.

216400 61282-53 

Soluble Concentrate 9.97

Agricultural premises and equipment

Swine farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, 

crates cabs and wheels Halters

Spray, mop, wipe 1/2-1 1/2 oz. per 

gallon of water, wet surface. 10 minute contact time.

216400 61282-53 

Soluble Concentrate 9.97

Agricultural premises and equipment

Horse Stables Hard non porous areas, including, 

walls, floors and premises

Spray, mop, wipe 1/2-1 1/2 oz. per 

gallon of water, wet surface. 10 minute contact time.

216400 61282-53 

Soluble Concentrate 9.97

Agricultural premises and equipment

Farm premises and equipment

Hard non porous areas, including, walls, floors and premises

Fog 1/2-1 1/2 oz. per 

gallon of water, wet surface. 10 minute contact time.

Preclean premisDo not allow penot enter until pthoroughly.

216400 62296-1 

Soluble Concentrate 5.25

Medical Premises and Equipment

Medical Institutions, premises and equipment

Use on hard, nonporous surfaces such as floors, walls, metal surfaces, painted surfaces, exterior bowl surfaces, empty basins, showers, 

and lavatory fixtures

Spray, mop, wipe 1 oz per 32 oz of 

water, 10 minute contact time.

Medical Premises and Equipment

Hospital semi-critical items Precleaning of Non-porous 

instruments or appliances prior to 

Spray, immersion 1 oz per 32 oz of 

water, 10 minute 

216400 62296-1 

Soluble Concentrate 5.25

q p pp p

terminal sterilization

,

contact time.

216400 62296-1 

Soluble Concentrate 5.25

Medical Premises and Equipment

Barber/beauty shop instruments.

Combs, brushes, razors, scissors Spray, immersion 1 oz per 32 oz of 

water, 10 minute contact time.

216400 62296-1 

Soluble Concentrate 5.25

Medical Premises and Equipment

Dental Premises and equipment

Use on hard, nonporous surfaces such as floors, walls, metal surfaces, painted surfaces, exterior bowl surfaces, empty basins, showers, 

and lavatory fixtures

Spray, mop, wipe 1 oz per 32 oz of 

water, 10 minute contact time.

216400 66171-1 

Soluble Concentrate 6.0

Medical Premises and Equipment

Medical Institutions, premises and equipment

Hard, inanimate, nonporous surfaces such as walls, floors, door handles, medical bed surfaces, bed frames, mattress springs, wheelchairs, light switches, linen carts, stretcher wheels, hampers, telephones, cleanup carts, bassinets, dressing 

Spray, mop, wipe 1/2 oz. per gallon of 

water, wet surface. 10 minute contact time.

18
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 66171-1 

Soluble Concentrate 6.0

Agricultural premises and equipment

Poultry Premises and Equipment

Floors, walls, and equipment, including incubators, hatchers, setters, trays, racks, carts, sexing tables, delivery trucks, troughs, rack, feeding and watering bins, buckets and fountains. , incubators. Vehicles including mats, crates, cabs and wheels.

Spray, mop, wipe 1/2 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 66171-1 

Soluble Concentrate 6.0

Agricultural premises and equipment

Poultry Premises and Equipment

Hatchery rooms Fog 1/2 gallon to 2.5 

gallons water in approved fogger appliance. One 

minute per 4 000 cu

Preclean premisDo not allow penot enter until pthoroughly.

216400 66171-1 

Soluble Concentrate 6.0

Agricultural premises and equipment

Shoe Baths Entrances to buildings and livestock 

housing areas.

Spray, mop, wipe 1/2 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 66171-1 

Soluble Concentrate 6.0

Residential and public access premises

Dog and Cat Kennels Hard non porous areas, including, 

walls, floors and premises

Spray, mop, wipe 1/2 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 66171-1 

Soluble Concentrate 6.0

Residential and public access premises

day care facilities, schools, hotels, motels, restaurants,

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1/2 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 66171-1 

Soluble Concentrate 6.0

Medical Premises and Equipment

Veterinary hospitals, clinics, premises and equipment

Instrument trays, operating tables, and other hard, nonporous premises and surfaces, including, walls and floors.

Spray, mop, wipe 1/2 oz. per gallon of 

water, wet surface. 10 minute contact time.

Agricultural premises and equipment

Cattle farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering 

li V hi l i l di t

Spray, mop, wipe 1/2 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 66171-1 

Soluble Concentrate 6.0

appliances. Vehicles including mats, 

crates, cabs and wheels. Halters, 

ropes and other types of equipment

216400 66171-1 

Soluble Concentrate 6.0

Agricultural premises and equipment

Swine farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, 

crates cabs and wheels Halters

Spray, mop, wipe 1/2 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 66171-1 

Soluble Concentrate 6.0

Agricultural premises and equipment

Horse Stables Hard non porous areas, including, 

walls, floors and premises

Spray, mop, wipe 1/2 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 66171-1 

Soluble Concentrate 6.0

Agricultural premises and equipment

Farm premises and equipment

Hard non porous areas, including, walls, floors and premises

Fog 1/2 oz. per gallon of 

water, wet surface. 10 minute contact time.

Preclean premisDo not allow penot enter until pthoroughly.

216400 66171-1 

Soluble Concentrate 6.0

Medical Premises and Equipment

Hospital semi-critical items Precleaning of Non-porous 

instruments or appliances prior to terminal sterilization

Spray, immersion 1/2 oz. per gallon of 

water, wet surface. 10 minute contact time.

19
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 66171-1 

Soluble Concentrate 6.0

Medical Premises and Equipment

Hospital Laundry Laundry, linens, blankets and diapers Pour 1 oz. per gallon of 

water, soak laundry. 10 minute contact time.

Pre-wash treatm

216400 66171-2 

Soluble Concentrate 3.0

Medical Premises and Equipment

Medical Institutions, premises and equipment

Hard, inanimate, nonporous surfaces such as walls, floors, door handles, medical bed surfaces, bed frames, mattress springs, wheelchairs, light switches, linen carts, stretcher wheels, hampers, telephones, cleanup carts, bassinets, dressing 

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 66171-2 

Soluble Concentrate 3.0

Agricultural premises and equipment

Poultry Premises and Equipment

Floors, walls, and equipment, including incubators, hatchers, setters, trays, racks, carts, sexing tables, delivery trucks, troughs, rack, feeding and watering bins, buckets and fountains. , incubators. Vehicles including mats, crates, cabs and wheels.

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 66171-2 

Soluble Concentrate 3.0

Agricultural premises and equipment

Poultry Premises and Equipment

Hatchery rooms Fog 1 gallon to 2.5 gallons 

water in approved fogger appliance. One minute per 4,000 cu. 

Ft

Preclean premisDo not allow penot enter until pthoroughly.

216400 66171-2 

Soluble Concentrate 3.0

Agricultural premises and equipment

Shoe Baths Entrances to buildings and livestock 

housing areas.

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

S l bl

Residential and public access premises

Dog and Cat Kennels Hard non porous areas, including, 

walls, floors and premises

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 

minute contact time

216400 66171-2 

Soluble 

Concentrate 3.0

premises minute contact time.

216400 66171-2 

Soluble Concentrate 3.0

Residential and public access premises

day care facilities, schools, hotels, motels, restaurants,

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 66171-2 

Soluble Concentrate 3.0

Medical Premises and Equipment

Veterinary hospitals, clinics, premises and equipment

Instrument trays, operating tables, and other hard, nonporous premises and surfaces, including, walls and floors.

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 66171-2 

Soluble Concentrate 3.0

Agricultural premises and equipment

Cattle farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, crates, cabs and wheels. Halters, 

ropes and other types of equipment

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 66171-2 

Soluble Concentrate 3.0

Agricultural premises and equipment

Swine farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, 

crates cabs and wheels Halters

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

20
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 66171-2 

Soluble Concentrate 3.0

Agricultural premises and equipment

Horse Stables Hard non porous areas, including, 

walls, floors and premises

Spray, mop, wipe 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 66171-2 

Soluble Concentrate 3.0

Agricultural premises and equipment

Farm premises and equipment

Hard non porous areas, including, walls, floors and premises

Fog 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

Preclean premisDo not allow penot enter until pthoroughly.

216400 66171-2 

Soluble Concentrate 3.0

Medical Premises and Equipment

Hospital semi-critical items Precleaning of Non-porous 

instruments or appliances prior to terminal sterilization

Spray, immersion 1 oz. per gallon of 

water, wet surface. 10 minute contact time.

216400 66171-2 

Soluble Concentrate 3.0

Medical Premises and Equipment

Hospital Laundry Laundry, linens, blankets and diapers Pour 1 oz. per gallon of 

water, soak laundry. 10 minute contact time.

Pre-wash treatm

216400 70385-7 

Soluble Concentrate 4.9

Medical Premises and Equipment

Medical premises, floors Carpets Hot water extraction, 

spin bonnet, immersion

2-4 oz per gallon of water

216400 70385-7 

Soluble Concentrate 4.9

Residential and public access premises

Residential and public access premises, floors

Carpets Hot water extraction, 

spin bonnet, immersion

2-4 oz per gallon of water

Commercial , Commercial , institutional, Carpets Hot water extraction, 2-4 oz per gallon of 

216400 70385-7 

Soluble Concentrate 4.9

institutional, and industrial premises

and industrial premises, floors

p

spin bonnet, immersion

p g

water

216400 70627-6 

Soluble Concentrate 10.5

Medical Premises and Equipment

Medical Institutions, premises and equipment

Use on hard, nonporous surfaces such as floors, walls, metal surfaces, painted surfaces, exterior bowl surfaces, empty basins, showers, conductive flooring and lavatory fixtures.

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 70627-6 

Soluble Concentrate 10.5

Medical Premises and Equipment

Dental Premises and equipment

Use on hard, nonporous surfaces such as floors, walls, metal surfaces, painted surfaces, exterior bowl surfaces, empty basins, showers, conductive flooring and lavatory fixtures.

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 70627-6 

Soluble Concentrate 10.5

Agricultural premises and equipment

Poultry Premises and Equipment

Floors, walls, and equipment, including incubators, hatchers, setters, trays, racks, carts, sexing tables, delivery trucks, troughs, rack, feeding and watering bins, buckets and fountains. , incubators. Vehicles including mats, crates, cabs and wheels.

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

21
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 70627-6 

Soluble Concentrate 10.5

Food handling processing equipment and premises

Meat and poultry processing plants

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

Food products aremoved from thproduct in accomust be thoroug

216400 70627-6 

Soluble Concentrate 10.5

Agricultural premises and equipment

Shoe Baths Entrances to buildings and livestock 

housing areas.

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 70627-6 

Soluble Concentrate 10.5

Residential and public access 

premises

Day care facilities, schools, hotels, motels, restaurants

Hard non porous areas, including, walls, floors and premises

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 70627-6 

Soluble Concentrate 10.5

Residential and public access premises

Dog and Cat Kennels Hard non porous areas, including, 

walls, floors and premises

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 70627-6 

Soluble Concentrate 10.5

Medical Premises and Equipment

Veterinary hospitals, clinics, premises and equipment

Instrument trays, operating tables, and other hard, nonporous premises and surfaces, including, walls and floors.

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 70627-6 

Soluble Concentrate 10.5

Agricultural premises and equipment

Cattle farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, crates, cabs and wheels. Halters, ropes, and other types of equipment used in handling and restraining animals

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 70627-6 

Soluble Concentrate 10.5

Agricultural premises and equipment

Swine farm premises and equipment

Floors, walls, and equipment, pens, stalls, chutes, troughs, racks, and other feeding and watering appliances. Vehicles including mats, crates, cabs and wheels. Halters, ropes, and other types of equipment used in handling and restraining animals

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

a as

216400 70627-6 

Soluble Concentrate 10.5

Agricultural premises and equipment

Horse Stables Hard non porous areas, including, 

walls, floors and premises

Spray, mop, wipe 1/2 oz. per gallon of 

water, 10 minute contact time. 

216400 67869-38

Soluble Concentrate 10

Industrial Processes and Water Systems

Industrial recirculating water cooling towers and evaporative condenser

Cooling tower and evaporative condenser sump or basins

Metered pump 2-8 pt. per 1000 

gallons (250-1000ppm)

216400 67869-38

Soluble Concentrate 10

Industrial Processes and Water Systems

Industrial process water Pipework, heat exchangers, and 

condenser tube sumps and tanks

Open pour, metered pump

0.8-8.0 pt. per 1000 gallons (100-1000ppm) up to once weekly

216400 67869-38

Soluble Concentrate 10

Industrial Processes and Water Systems

Paper mill process water Paper and paperboard process water Open pour, metered 

pump

0.2 to 3.0 pt per ton (10-250ppm) of finished paper up to three time per day

216400 67869-38

Soluble Concentrate 10

Industrial Processes and Water Systems

Industrial and/or commercial air commercial air conditioning and humidifying systems

A/C and humidifying systems Open pour, metered 

pump

3.8-7.6 pts. Per 1000 gallons (50-100ppm)

22
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 67869-38

Soluble Concentrate 10

Industrial Processes and Water Systems

Oil and gas fluids terrestrial and offshore drilling muds, 

fluids and gels

Open pour, metered pump

4-8 pt. per 1000 gallons (500-1000ppm)

216400 67869-38

Soluble Concentrate 10

Industrial Processes and Water Systems

Oil process water Oil and gas well injection and 

formation waters

Open pour, metered pump

2-8 pt. per 1000 gallons (250-1000ppm) up to once per week

216400 67869-38

Soluble Concentrate 10

Industrial Processes and Water Systems

Oil and gas pipeline and tank maintenance

Water bottoms an crude and refined hydrocarbon storage tanks, piping and transportations systems

Metered pump 2-16 pt. per 1000 

gallons (250-2000ppm) up to once per day

216400 67869-38

Soluble Concentrate 10

Material preservatives

Metalworking fluids Soluble oils, semi-synthetic and 

synthetic fluids

Open pour, metered pump

2.5-10 gallons per 1000 gallons (2500-10000ppm) up to once per day

216400 67869-38

Soluble Concentrate 10

Material preservatives

Paper Mills Bulk Pulp Open pour, metered 

pump

4-16pt. per 1000 gallons (500-2000ppm) up to once per week

216400 67869-38

Soluble Concentrate 10

Material preservatives

Adhesives Non-food contact adhesives Open pour, metered 

pump

1-5 pt per 100lb by weight

216400 67869-38

Soluble Concentrate 10

Material preservatives

Absorbent Clays Absorbent Clays Open pour, metered 

pump

0.4-0.2 oz per 100 lbs by weight

Material preservatives

Water based suspension concentrates, Paints and other emulsions

Starch, pigment and mineral slurries, acrylic, slyrene acrylic, polyvinyl acetate and other latex emulsion, 

Open pour, metered pump

8-40 pt. per 1000 gallons (1000-5000ppm) up to once 

216400 67869-38

Soluble Concentrate 10

latex emulsion based paints, photographic emulsion, silicone and other antifoam emulsion systems

pp ) p

per week

216400 67869-38

Soluble Concentrate 10

Material preservatives

Water based printing inks and fount solutions

Fountain solutions Open pour, metered 

pump

8-40 pt. per 1000 gallons (1000-5000ppm) up to once per week

216400 67869-38

Soluble Concentrate 10

Material preservatives

In can preservation. Water based printing inks and fount 

solutions

Open pour, metered pump

4-8pt. per 1000 gallons (500-1000ppm) up to once per week

216400 68708-9

Ready-to-Use Solution 8.8

Material preservatives

Water based suspension concentrates

Starch, pigment and extender slurries Open pour, metered 

pump

8-40 pint per 1000 gallons (1000-5000ppm)

216400 68708-9

Ready-to-Use Solution 8.8

Material preservatives

Latex emulsion concentrates and emulsion based paints

Paints and latex emulsion systems Open pour, metered 

pump

8-40 pint per 1000 gallons (1000-5000ppm)

23
 2770, Bronopol 

Appendix A

PC Code EPA Reg 

Number used for Max. Appl. 

Rate

Formulation % Active 

Ingredient in End Use Formulation

Use Category Use Site Treatment Site/Surfaces Method of 

Application

Max Application/Use Rate

Use Limitation

216400 68708-9

Ready-to-Use Solution 8.8

Material preservatives

Antifoam emulsions Defoamers Open pour, metered 

pump

8-40 pint per 1000 gallons (1000-5000ppm)

216400 68708-9

Ready-to-Use Solution 8.8

Material preservatives

water based coatings Paper coatings Open pour, metered 

pump

None listed.

216400 74655-14

Ready-to-Use Solution 5.3

Industrial Processes and Water Systems

Pulp and paper water systems

Pulp and paper mill and additive systems

Open pour, metered pump

3.0-20.8 lbs per 1000 gallons (360-2500ppm), maximum 5.0 lbs. per ton of pulp or paper produced.

Non-food conta

216400 74655-14

Ready-to-Use Solution 5.3

Material preservatives

Papermaking Defoamers Open pour, metered 

pump

2500-3000ppm Non-food conta

216400 74655-14

Ready-to-Use Solution 5.3

Material preservatives

Papermaking Clay Open pour, metered 

pump

2500-3000ppm Non-food conta

216400 74655-14

Ready-to-Use Solution 5.3

Material preservatives

Papermaking Starch, broke and calcium carbonate Open pour, metered 

pump

650-750ppm Non-food conta

216400 74655-14

Ready-to-Use Solution 5.3

Material preservatives

Papermaking Alum Open pour, metered 

pump

350-450ppm Non-food conta

Material 

ti

Papermaking Dyes and titanium oxide Open pour, metered 40-80ppm Non-food conta

216400 74655-14

Ready-to-Use Solution 5.3

preservatives pump

216400 74655-14

Ready-to-Use Solution 5.3

Material preservatives

Papermaking Emulsions, adhesives and polymers Open pour, metered 

pump

200-300ppm Non-food conta

24