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                                                                   EXHIBIT 10.12

       **CERTAIN CONFIDENTIAL MATERIAL CONTAINED IN THIS DOCUMENT HAS BEEN
    OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION
     PURSUANT TO 17 C.F.R. SUBSECTION 200.80(B)(4), 200.83 AND 230.406.**

               AMENDMENT TO EXCLUSIVE LICENSE AND SUPPLY AGREEMENT
                                     BETWEEN
                            ICN PHARMACEUTICALS, INC.
                                       AND
                              SCHERING-PLOUGH LTD.
                               DATED JULY 28, 1995

         This Amendment, effective as of the last date below (the "Effective
Date"), to the Exclusive License and Supply Agreement between ICN
Pharmaceuticals, Inc. ("ICN") and Schering-Plough Ltd. ("Schering") dated July
28, 1995 (the "Agreement") is entered into by and between the parties hereto
with reference to the facts below. Terms with initial capitals which are not
specifically defined in this Amendment shall have the defined meaning set forth
in the Agreement.

         WHEREAS, Section 7.1 of the Agreement grants the right to ICN,
following receipt of Regulatory Approval in the EU, to distribute, market, use,
make, have made and sell the Product for the treatment of chronic hepatitis C,
at ICN's expense, in the EU; and

         WHEREAS, the Parties wish to amend the Agreement to increase certain
royalty payments to ICN in exchange for ICN relinquishing its rights and
granting to Schering exclusive rights to develop, distribute, market, use, make,
have made and sell the Product alone or as part of a combination therapy for the
treatment of chronic hepatitis C in the EU; and

         WHEREAS, the Parties also wish to modify certain other provisions of
the Agreement in order to achieve consistency with the objective of this
amendment granting Schering exclusive rights to the Product in the Territory;
and

         WHEREAS, pursuant to Section 3.2(e) of the Agreement, ICN is required
to reimburse Schering for [REDACTED], up to a maximum amount of $5 million, of
the reasonable costs and expenses incurred by Schering in pursuing Regulatory
Approval in the EU and whereas ICN has to date made no such reimbursement; and
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         WHEREAS, ICN has incurred certain costs in anticipation of co-promoting
the Product in the EU and Schering has agreed to reimburse ICN for such amounts
expended by ICN; and

         WHEREAS, the Parties wish to resolve certain additional matters between
them and provide for additional value to ICN of $16.5 million.

         NOW, THEREFORE, in consideration of the foregoing premises and the
mutual covenants and obligations below, the Parties agree as follows:

          1. ICN acknowledges that in exchange for the receipt of additional
value to ICN of $16.5 million the matters set forth below are resolved between
the parties. From the $16.5 million in additional value to ICN, Schering shall
deduct $5 million and Schering acknowledges that ICN shall not be required to
reimburse Schering for [REDACTED], up to a maximum amount of $5 million, of the
reasonable costs and expenses incurred by Schering in pursuing Regulatory
Approval in the EU, as provided in Section 3.2(e) of the Agreement, and such
debt of ICN is forgiven by Schering.

          2. Within ten (10) business days after the Effective Date, Schering
shall pay to ICN the balance of $11.5 million, by wire transfer of immediately
available funds to an account designated by ICN.

          3. ICN acknowledges and agrees that payment by Schering shall be in
full and complete satisfaction of any and all rights and/or claims that ICN has
or may have relating to:

          (a)      royalties due ICN under the Agreement, as amended by this
                   Amendment Agreement, for any and all [REDACTED] (but not
                   [REDACTED]), including, as described in Section 6.2(b)
                   of the Agreement, which [REDACTED] are in existence at the
                   Effective Date and continue past the Effective Date; and

          (b)      [REDACTED]; and

          (c)      reimbursement for the amounts that ICN has expended in
                   anticipation of co-promoting the Product in the EU. In
                   addition, ICN transfers to Schering ownership of certain
                   pre-marketing activities in exchange for the consideration
                   provided to ICN under this Agreement.


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          4. The Parties agree that clinical trials where patients are
administered [REDACTED] (those with protocols and case report forms) were not
and are not subject to any royalty obligations under the Agreement. Clinical
trials utilizing ribavirin monotherapy up to [REDACTED] of Schering's Net Sales
of ribavirin on a country-by-country basis (measured in units for this purpose)
are not subject to any royalty obligations under the Agreement. However,
clinical trials utilizing ribavirin monotherapy in excess of [REDACTED] of
Schering's Net Sales of ribavirin on a country-by-country basis (measured in
units for this purpose) shall be subject to royalty obligations under the
Agreement. Examples of clinical trials, include but are not limited to,
[REDACTED].

                  Notwithstanding anything set forth in this Section 4, during
the first [REDACTED] period following Regulatory Approval of the Product in any
country of the Territory on a country-by-country basis, except for specific
investigator initiated studies to which the Parties mutually agree, no
investigator initiated studies shall be subject to the minimum royalty payment
to ICN, as such minimum royalty is set forth in Section 6.2. If after the
[REDACTED] period set forth above, except for specific investigator initiated
studies to which the Parties mutually agree, there are investigator initiated
studies continuing in the relevant country, then ICN shall be entitled and
Schering shall pay to ICN, [REDACTED] of the minimum royalty on such use of
ribavirin. Beginning one year after such [REDACTED] period (i.e., [REDACTED]
after Regulatory Approval of the Product in the relevant country), except for
specific investigator initiated studies to which the Parties mutually agree, if
the investigator initiated studies are still continuing in the relevant country,
then ICN shall be entitled and Schering shall pay to ICN, [REDACTED] of the
minimum royalty on such use of ribavirin.

          5. ICN further acknowledges and agrees that all minimum royalties due
ICN through the Effective Date shall be satisfied upon payment to ICN of the
amounts set forth in this agreement. In addition, the audit of Schering's books
and records as requested by ICN by notice dated June 9, 1998, shall cease and
ICN hereby waives and relinquishes its right under the Agreement to examine the
books and records of Schering for minimum royalty purposes from the period of
the inception of the Agreement through the Effective Date.

          6. The Parties further agree that royalties in the EU shall be
calculated as Net Sales of ribavirin multiplied by the applicable royalty rate
set forth in subsection 6.2(a), provided, however, that from such calculation,
Schering shall deduct its [REDACTED]. When ribavirin is sold in a [REDACTED],
ribavirin net sales are calculated by determining [REDACTED].

                                      -3-
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                  With regard to discounts, rebates and charge back payments
(collectively, "Discount"), when applied to [REDACTED], the Discount applied to
the [REDACTED] shall be the average discount applied to [REDACTED] in the
country, on a country-by-country basis. The remainder of the Discount will be
applied to [REDACTED]. Following [REDACTED] of sales of the [REDACTED] in a
Major Market, and thereafter on an annual basis, in the event ICN reasonably
believes that there has been an inequitable apportionment of the Discount
relating to [REDACTED], then ICN may request a meeting with Schering to resolve
in good faith the issue of the equitable apportionment of the Discount of
[REDACTED].

          7. ICM further acknowledges and agrees that Schering has paid in full
and completely satisfied its obligations with regard to the Portugal "Virazide
Transfer" and ICN acknowledges that such amounts were correctly deducted from
applicable royalties due ICN.

          8. Sections of the Agreement relating to or implementing ICN's right
to distribute, market and sell the Product in the EU shall be deleted in order
to give effect to the intent of the Parties to amend the Agreement to grant
Schering exclusive rights to the Product in the Territory with no retained
marketing rights by ICN in the EU, except as provided in Section 12.6 ("Effects
of Termination by ICN"). Such amendments to the Agreement are as follows:

-    Section 2.4 ("Prices") shall be amended to delete the second sentence in
     its entirety. The remainder of Section 2.4 shall remain the same.

-    Sections 3.1 (d) ("Research and Development Activities") shall be amended
     to delete the first two sentences and the Section shall read in its
     entirety as follows:

                  "(d) ICN will use it reasonable efforts to apply the
         publication procedures set forth in Exhibit F to any studies that
         commenced prior to and are planned as of the Effective Date."

-    Section 3.2(b) ("Product Registrations"). The first sentence shall be
     amended to delete the first five words ("Except as to the EU") in their
     entirety. The remainder of Section 3.2(b) shall remain the same.


                                      -4-
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     Section 3.2(c) ("Product Registrations"). This Section 3.2(c) shall be
     deleted in its entirety. Section 3.2(d) shall be renumbered as Section
     3.2(c) but shall otherwise remain the same.

-    Section 3.2(e) ("Product Registrations"). This Section 3.2(e) shall be
     deleted in its entirety.

-    Section 3.3(a) ("Pricing and Reimbursement Approvals"). The second sentence
     ("In the EU, ICN shall be responsible for ICN's pricing and reimbursement
     approvals and structure.") shall be deleted in its entirety. The remainder
     of Section 3.3(a) shall remain the same.

-    Section 3.3(b) ("Pricing and Reimbursement Approvals"). The first sentence
     shall be amended to delete the first five words in their entirety and the
     last sentence of Section 3.3(b) shall be deleted in its entirety. Amended
     Section 3.3(b) shall thereupon read in its entirety as follows:

         "(b) Each pricing and reimbursement approval shall be placed in
     Schering's name or the name of a designated Schering Affiliate unless local
     law requires, or ICN and Schering otherwise agree, that such approval be in
     the name of ICN or a designated ICN Affiliate."

-    Section 4.1 ("Diligence in Marketing the Product"). The last sentence shall
     be deleted in its entirety. The remainder of Section 4.1 shall remain the
     same.

-    Section 4.3(a) ("Trademark Registrations and Infringements"). The last
     sentence shall be deleted in its entirety. The remainder of Section 4.3(a)
     shall remain the same.

-    Section 4.3(e) ("Trademark Registrations and Infringements"). The
     parenthetical on lines two through four of the Section ("(including without
     limitation, the rights to manufacture the Product and to distribute, market
     and sell the Product in the EU under the ICN Trademark)") shall be deleted
     in its entirety. The remainder of Section 4.3(e) shall remain the same.

-    Section 5.3(b) ("Product Sampling"). This subsection shall be deleted in
     its entirety. Section 5.3(c) shall be renumbered 5.3(b).


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-    Current Section 5.3(c) ("Product Sampling"). The last sentence of the
     section shall be deleted in its entirety. This section has been renumbered
     5.3(b) and the remaining sentence of new Section 5.3(b) shall remain the
     same.

-    Section 12.5(b)(ii) ("Effects of Termination by Schering"). This subsection
     shall be amended to delete the phrase "outside of the EU" from the eighth
     line of the subsection and subsection 12.5(b)(ii) shall thereupon read in
     its entirety as follows:

         "(ii) Schering shall grant ICN reference to any Regulatory Approvals
 and pricing or reimbursement approvals relating to the Product in the
 Territory;"

-    Section 12.5(d)(i) ("Effects of Termination by Schering"). This subsection
     shall be amended to delete the phrase "including in the EU" from the fifth
     line of the subsection and subsection 12.5(d)(i) shall thereupon read in
     its entirety as follows:

         "(i) Schering shall retain a worldwide, perpetual, fully-paid up,
exclusive license (exclusive even as to ICN) in and to the Know-How to enable
Schering to develop, make, have made, use, sell and distribute Product in the
Territory;"

         9. Section 6.2 of the Agreement shall be amended to read in its
entirety as follows:

                  "6.2 Royalty Payment. In partial consideration of the grant of
rights to Schering by ICN under this Agreement, Schering shall pay ICN a royalty
in the following amounts:

                  (a) with respect to sales of Product, alone or as part of a
[REDACTED], in the EU, the following royalty, [REDACTED], but in no event less
than [REDACTED] of Net Sales:

                     (i) [REDACTED];

                     (ii) [REDACTED]; and

                    (iii) [REDACTED];


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                  (b) With respect to sales of Product, alone or as part of a
combination therapy, in the Territory other than the EU:

                     (i) [REDACTED];

                     (ii) [REDACTED]; and

                     (iii) [REDACTED];

provided, however, that in no event shall the royalty on sales of the Product,
alone or as part of a combination therapy, in any country in the Territory be
less that [REDACTED] per capsule sold based on a [REDACTED], [REDACTED] per
capsule sold based on a [REDACTED], and [REDACTED] per capsule sold based on a
[REDACTED], such amounts to be proportionately adjusted based on a scale of
[REDACTED] for other capsule sizes less than [REDACTED] and based on a scale of
[REDACTED] for other capsule sizes in excess of [REDACTED]. In the event oral
ribavirin from any third party becomes commercially available in any country in
the Territory, then Schering shall not be obligated to pay the minimum royalty
provided for in this Section 6.2 for that country, provided, however, that
notwithstanding the foregoing, (A) Schering shall be obligated to pay the
minimum royalty provided for in this Section 6.2 with respect to sales of the
Product in any of [REDACTED] for a maximum of [REDACTED] from first introduction
of oral ribavirin, at a [REDACTED], into any of [REDACTED]; (B) Schering shall
be obligated to pay the minimum royalty provided for in this Section 6.2 with
respect to sales of the Product in the [REDACTED] for a maximum of [REDACTED]
years from first introduction of oral ribavirin, at a [REDACTED], in [REDACTED]
and (C) Schering shall be obligated to pay the minimum royalty provided for in
this Section 6.2 with respect to sales of the Product in [REDACTED] for a
maximum of [REDACTED] from first introduction of oral ribavirin, at a
[REDACTED], [REDACTED]. The phrase [REDACTED] as used in this Section 6.2 shall
mean [REDACTED].


                                      -7-
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[REDACTED] For purposes of this Section 6.2, the current actual net selling
price shall be determined on a country-by-country basis, for each calendar
quarter, by dividing the Net Sales of capsules of a particular capsule strength
by the total number of capsules of the same strength that were sold and sampled
in such country during such period. Each Party shall have the right to audit the
books and records of the other Party for the purpose of verifying the current
actual net selling price, in accordance with the procedures set forth in Section
6.10."

          10. The last sentence of Section 6.12 shall be amended to read in its
entirety as follows:

          "Notwithstanding the foregoing, (i) in no event shall ICN be liable
for any deficiency, fine, assessment or penalty resulting from Schering's
failure to withhold the proper amount in accordance with the written
instructions of ICN to Schering given in accordance with Section 15.7 hereof,
and (ii) in no event shall ICN be liable for any deficiency, fine, assessment or
penalty resulting from Schering's failure to withhold the proper amount as a
result of Schering's negligence in calculating or paying such withholding tax.
In the event ICN is required to pay any such deficiency, or any fine, assessment
or penalty for any such deficiency, Schering shall promptly reimburse ICN for
such payments". The remainder of Section 6.12 shall remain the same.

          11. Section 7.1 of the Agreement entitled "ICN's Marketing Rights"
shall be deleted in its entirety except that the last sentence shall remain and
have the following added at the end of the existing sentence "or is known to
have sold the Product outside of Egypt." Section 7.1 shall be re-titled "ICN's
Marketing Rights in Egypt." and shall read in its entirety as follows:

         7.1 ICN's Marketing Rights in Egypt. In recognition of ICN's current
sales of the Product for the treatment of chronic hepatitis C pursuant to a
Regulatory Approval in

                                      -8-
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Egypt, ICN shall have the right under its existing contractual obligations (on a
semi-exclusive basis with Schering) at any time to distribute, market, use and
sell the Product for the treatment of chronic hepatitis C, at ICN's expense in
Egypt; provided, however, that ICN shall not sell the Product to any entity in
Egypt that could reasonably be expected to resell the Product outside Egypt or
is known to have sold the Product outside of Egypt."

         12. In order for Schering to derive the full benefits of the Agreement
with ICN, it is important that Schering be allowed to fully exploit the
exclusive rights granted to it under the Agreement. Without restricting ICN from
being able to fully exploit its rights to further develop ribavirin in
accordance with the terms of the Agreement for use in therapeutic areas other
than hepatitis C, ICN agrees not to enter into any agreements, understandings or
arrangements of any kind with any third or affiliated parties that directly or
indirectly interferes with the exclusive rights of Schering to make, have made,
develop, use, sell and distribute the Product in the Territory for the treatment
of hepatitis C. In addition, ICN agrees not to provide Product, Know-How, data
or any other such information or in any way facilitate the provision of Product,
Know-How, data or other such information with or without compensation for any
purpose that would allow, or might allow, a third or affiliated party to obtain
a health registration for the Product or enable the third or affiliated party to
compete against Schering by using the Product, alone or as part of a combination
therapy, for the treatment of hepatitis C. In the event, Schering is able to
provide ICN with information reasonably demonstrating that a third or affiliated
party is using Product, Know-How, data or any other such information provided or
facilitated by ICN to attempt to obtain a health registration for the Product or
enabling it to compete against Schering by using the Product, ICN will
immediately discontinue providing or facilitating the provision of such Product,
Know-How, data or other such information to the third or affiliated party and
take all reasonable steps to recover or withdraw permission to use such Product,
Know-How, date or other such information.

          13. Without limiting the foregoing, ICN further acknowledges that it
is hereby releasing and forever discharging Schering, and any affiliated
entities, and their officers, directors, shareholders, employees and
representatives, of and from any and all actions, claims, liabilities and
demands now existing or which may hereafter arise including all claims for
damages, costs and fees, including attorneys' fees, of any description
whatsoever, arising out of or relating to any claim for (a) royalties due ICN
under the Agreement, as amended by this Amendment Agreement, for any and all

                                      -9-
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[REDACTED] (but not [REDACTED]) including, as described in
Section 6.2(b) of the Agreement, both prior to and until Regulatory Approval of
the Product in each country where such [REDACTED] have been or
are [REDACTED], (b) royalties due ICN for any and all [REDACTED] and
any [REDACTED] of Product through the Effective Date, (c) the calculation of
Schering's [REDACTED] through the Effective Date, (d) any alleged breach of
Section 3.2(c) of the Agreement through the Effective Date, or (e) reimbursement
of any funds expended by ICN in anticipation of co-promotion of Product in the
EU, (f) any of the matters that are the subject of this Agreement.

          14. In addition and in further consideration of the foregoing, ICN
hereby expressly waives any and all rights and benefits conferred upon it by the
provisions of Section 1542 of the Civil Code of the State of California, which
reads as follows:

          "A general release does not extend to claims which the creditor does
          not know or suspect to exist in his favor at the time of executing the
          release, which if known by him must have materially affected his
          settlement with the debtor."

          15. It is understood that neither the execution of this Agreement nor
any other action taken by Schering in connection with this Agreement constitutes
an admission by Schering or any affiliated entity of any violation of any law,
duty or obligation, and this Agreement is entered into without admission of
liability of any kind and is made in discharge, compromise, settlement and
satisfaction of all actions, claims and demands of any kind whatsoever by ICN
against Schering and any affiliated entities.

          16. The terms, conditions and existence of this Agreement shall be
treated by the Parties on a confidential basis, subject to Section 9.2 of the
Agreement ("No Publicity") and subject further to appropriate disclosure to
employees and shareholders of Schering-Plough Corporation (the corporate parent
of Schering) and its affiliates and/or ICN, or as otherwise required by law.
Each of Schering and ICN agrees to coordinate both the timing and content of any
public announcements relating to this Amendment Agreement and any such public
announcements shall be subject to the review and approval of the Parties prior
to public disclosure.

          17. This Agreement shall bind the Parties and their successors or
assigns.

          18. The Parties agree that the laws of the state of New Jersey,
exclusive of its conflicts of laws rules, shall be controlling with respect to
the validity, performance and interpretations of the terms of this Agreement.


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          19. This Amendment to the Agreement is incorporated therein and
expressly made a part thereof.

          20. This Amendment to the extent set forth herein, amends, modifies
and supplements the Agreement. This Agreement contains the entire agreement
between the Parties hereto, and the terms of this Agreement are contractual and
not a mere recital. Except as expressly. modified herein, all of the terms and
provisions of the Agreement remain in full force and effect and cannot be
amended, modified or changed in any way whatsoever except by a written
instrument duly executed by the Parties hereto.

          IN WITNESS WHEREOF, the Parties have executed this Amendment effective
as of the last date below.

SCHERING-PLOUGH LTD.                           ICN PHARMACEUTICALS, INC.

By:        /s/ David Poorvin                  By:      /s/ David C. Watt
     ----------------------------------             ---------------------------
           David Poorvin                               David C. Watt

Title:   Prokurist                            Title:   Executive Vice President
                                                       General Counsel &
                                                       Corporate Secretary

Date:         16 July 1988                    Date:
      ---------------------------------            ----------------------------




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