Federal Register / Vol. 77, No. 31 / Wednesday, February 15, 2012 / Notices 8859 

mother-infant pairs that have reported 

associations with birth outcomes, 

childhood neurobehavioral and 

neurodevelopment outcomes in the 

offspring when evaluated in neonates, 

infants, and young children. 

In 2008, the FIFRA Scientific 

Advisory Panel (SAP) reviewed a draft 

science issue paper on the human 

health effects of chlorpyrifos which 

provided a preliminary review of the 

scientific literature on experimental 

toxicology and epidemiology studies 

available at that time. In 2010, the 

Agency developed a draft ‘‘Framework 

for Incorporating Human Epidemiologic 

& Incident Data in Health Risk 

Assessment’’ which provides the 

conceptual foundation for evaluating 

multiple lines of scientific evidence in 

the context of the understanding of the 

adverse outcome pathway (or mode of 

action). This draft framework uses 

modified Bradford Hill Criteria to 

evaluate the sufficiency of evidence to 

establish key events within a mode of 

action(s) and explicitly considers such 

concepts as strength, consistency, dose 

response, temporal concordance and 

biological plausibility. Since the 2008 

SAP on chlorpyrifos, the Agency has 

performed further analyses on the 

existing and new epidemiology results 

in mothers and children, available 

biomonitoring data, and experimental 

toxicology studies evaluating proposed 

adverse outcome pathways in the 

context of human health risk 

assessment. Specifically, the Agency is 

evaluating available literature on the 

potential for chlorpyrifos to cause long 

term adverse effects from early life 

exposure, in vivo and in vitro studies 

evaluating mechanistic aspects of 

chlorpyrifos, and the potential for 

adverse effects below doses established 

from ChE inhibition that are used for 

regulatory purposes. At this time, the 

Agency is working towards a weight of 

evidence evaluation integrating the 

epidemiology studies with the 

experimental toxicology studies for the 

neurodevelopmental outcomes. This 

analysis is complex and multifaceted as 

it involves different lines of scientific 

evidence (i.e., in vivo and in vitro 

experimental toxicology studies, 

explicit consideration of adverse 

outcome pathways, exposure, 

epidemiology, and biomonitoring data). 

As such, the Agency believes that peer 

review on the status of the current 

analysis is important. 

C. FIFRA SAP Documents and Meeting 

Minutes 

EPA’s background paper, related 

supporting materials, charge/questions 

to FIFRA SAP, FIFRA SAP composition 

(i.e., members and ad hoc members for 

this meeting), and the meeting agenda 

will be available by approximately midMarch. In addition, the Agency may 

provide additional background 

documents as the materials become 

available. You may obtain electronic 

copies of these documents, and certain 

other related documents that might be 

available electronically, at http:// 

www.regulations.gov and the FIFRA 

SAP homepage at http://www.epa.gov/ 

scipoly/sap. 

FIFRA SAP will prepare meeting 

minutes summarizing its 

recommendations to the Agency 

approximately 90 days after the 

meeting. The meeting minutes will be 

posted on the FIFRA SAP Web site or 

may be obtained from the OPP 

Regulatory Public Docket at http:// 

www.regulations.gov. 

List of Subjects 

Environmental protection, Pesticides 

and pests. 

Dated: February 2, 2012. 

Frank Sanders, 

Director, Office of Science Coordination and 

Policy. 

[FR Doc. 2012–3280 Filed 2–14–12; 8:45 am] 

BILLING CODE 6560–50–P 

ENVIRONMENTAL PROTECTION 

AGENCY 

[FRL–9632–4] 

National Advisory Council for 

Environmental Policy and Technology 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Cancellation and Rescheduling 

of National Advisory Council for 

Environmental Policy and Technology 

(NACEPT) Committee Meeting. 

SUMMARY: EPA announced in the 

Federal Register on January 12, 2012 

[FRL–9617–7] a National Advisory 

Council for Environmental Policy and 

Technology (NACEPT) Meeting to be 

held at the EPA Potomac Yard 

Conference Center, One Potomac Yard, 

2777 S. Crystal Drive, Arlington, VA 

22202. Under the Federal Advisory 

Committee Act, Public Law 92463, EPA 

gives notice of cancellation and 

rescheduling of that public meeting for 

the National Advisory Council for 

Environmental Policy and Technology 

(NACEPT). NACEPT provides advice to 

the EPA Administrator on a broad range 

of environmental policy, technology, 

and management issues. NACEPT 

members represent academia, industry, 

non-governmental organizations, and 

local, state, and tribal governments. The 

purpose of this meeting is to begin 

developing recommendations to the 

Administrator regarding actions that 

EPA can take in response to the 

National Academy of Sciences Report 

on ‘‘Incorporating Sustainability in the 

U.S. Environmental Protection Agency.’’ 

A copy of the agenda for the meeting 

will be posted at http:// 

www.epa.govofacmo/nacept/calnacept.htm. 

DATES: NACEPT has cancelled the twoday public meeting scheduled for 

February 13, 2012, from February 14, 

2012. NACEPT will now hold the twoday public meeting on Monday, March 

26, 2012, from 9 a.m. to 5:30 p.m. (EST) 

and Tuesday, March 27, 2012 from 8:30 

a.m. to 2 p.m. (EST). 

ADDRESSES: The meeting will be held at 

the EPA East Building Room 1153, 1201 

Constitution Avenue NW., Washington, 

DC 20004. 

FOR FURTHER INFORMATION CONTACT: 

Mark Joyce, Acting Designated Federal 

Officer, joyce.mark@epa.gov, (202) 564– 

2130, U.S. EPA, Office of Federal 

Advisory Committee Management and 

Outreach (1601M), 1200 Pennsylvania 

Avenue NW., Washington, DC 20460. 

SUPPLEMENTARY INFORMATION: Requests 

to make oral comments or to provide 

written comments for the March 26–27, 

2012, NACEPT meeting should be sent 

to Eugene Green at 

green.eugene@epa.gov by Monday, 

March 19, 2012. The meeting is open to 

the public, with limited seating 

available on a first-come, first-served 

basis. Members of the public wishing to 

attend should contact Eugene Green at 

green.eugene@epa.gov or (202) 564– 

2432 by March 19, 2012. 

Meeting Access: Information regarding 

accessibility and/or accommodations for 

individuals with disabilities should be 

directed to Eugene Green at the email 

address or phone number listed above. 

To ensure adequate time for processing, 

please make requests for 

accommodations at least 10 days prior 

to the meeting. 

Dated: February 7, 2012. 

Mark Joyce, 

Acting Designated Federal Officer. 

[FR Doc. 2012–3533 Filed 2–14–12; 8:45 am] 

BILLING CODE 6560–50–P 


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