Registration Notice Conditional v.20150320 

U.S. ENVIRONMENTAL PROTECTION AGENCY 

Office of Pesticide Programs 

Registration Division (7505P) 

1200 Pennsylvania Ave., N.W. 

Washington, D.C. 20460

EPA Reg. Number:

71512-23 

Date of Issuance: 

7/21/15 

NOTICE OF PESTICIDE: 

 X Registration 

 Reregistration

Term of Issuance: 

Conditional 

 (under FIFRA, as amended)

Name of Pesticide Product:

Isofetamid Turf Fungicide 

Name and Address of Registrant (include ZIP Code): 

Michael Peplowski 

ISK Biosciences Corporation 

7470 Auburn Road, Suite A 

Concord, OH 44077 

Note: Changes in labeling differing in substance from that accepted in connection with this registration must be submitted to and accepted by the 

Registration Division prior to use of the label in commerce. In any correspondence on this product always refer to the above EPA registration number.

On the basis of information furnished by the registrant, the above named pesticide is hereby registered 

under the Federal Insecticide, Fungicide and Rodenticide Act. 

Registration is in no way to be construed as an endorsement or recommendation of this product by the 

Agency. In order to protect health and the environment, the Administrator, on his motion, may at any 

time suspend or cancel the registration of a pesticide in accordance with the Act. The acceptance of any 

name in connection with the registration of a product under this Act is not to be construed as giving the 

registrant a right to exclusive use of the name or to its use if it has been covered by others. 

This product is conditionally registered in accordance with FIFRA section 3(c)(7)(C). You must comply 

with the following conditions: 

1. Submit and/or cite all data required for registration/reregistration/registration review of your 

product under FIFRA when the Agency requires all registrants of similar products to submit such 

data. 

Signature of Approving Official:

Tony Kish, Product Manager 22 

Fungicide Branch, Registration Division (7505P) 

Date: 

 7/21/15

EPA Form 8570-6 
Page 2 of 2 

EPA Reg. No. 71512-23 

Decision No. 474287 

2. You are required to submit to the Agency the following three studies: acute oral toxicity to larval 

honey bees; chronic oral toxicity to larval honey bees; and chronic oral toxicity to adult honey 

bees. Protocols for each of the chronic studies are required prior to initiating the studies. The 

protocols are due 3 months from the date of this Registration Notice. The studies are due 12 

months from the date of this Registration Notice. Thus, the 12 months includes submission and 

review of both the protocols and data. Your failure to provide these data in a timely or adequate 

manner may result in initiation of a cancellation action against your registration. 

3. Make the following label change before you release the product for shipment: 

 

 Revise the EPA Registration Number to read, “EPA Reg. No. 71512-23.” 

4. Submit one copy of the final printed label for the record before you release the product for 

shipment. 

Should you wish to add/retain a reference to the company’s website on your label, then please be aware 

that the website becomes labeling under the Federal Insecticide Fungicide and Rodenticide Act and is 

subject to review by the Agency. If the website is false or misleading, the product would be misbranded 

and unlawful to sell or distribute under FIFRA section 12(a)(1)(E). 40 CFR 156.10(a)(5) list examples 

of statements EPA may consider false or misleading. In addition, regardless of whether a website is 

referenced on your product’s label, claims made on the website may not substantially differ from those 

claims approved through the registration process. Therefore, should the Agency find or if it is brought to 

our attention that a website contains false or misleading statements or claims substantially differing from 

the EPA approved registration, the website will be referred to the EPA’s Office of Enforcement and 

Compliance. 

If you fail to satisfy these data requirements, EPA will consider appropriate regulatory action including, 

among other things, cancellation under FIFRA section 6(e). Your release for shipment of the product 

constitutes acceptance of these conditions. A stamped copy of the label is enclosed for your records. 

Please also note that the record for this product currently contains the following CSF: 

 Basic CSF dated 01-04-2013 

If you have any questions, please contact Heather Garvie by phone at 703-308-0034, or via email at 

garvie.heather@epa.gov. 

Enclosure 
FIRST AID

a poison control center or doctor 

diately for treatment advice. 

 person sip a glass of water if able to 

ow.

ot induce vomiting unless told to do so by a

n control center or doctor. 

ot give anything to an unconscious person.

off contaminated clothing. 

 skin immediately with plenty of soap and 

 for 15-20 minutes. 

a poison control center or doctor for 

ment advice. 

er or label with you when calling a poison 

r doctor, or going for treatment.

T LINE NUMBER 

mergency Assistance (Human or Animal) 

ll 1-888-484-7546.

ncy, Spill, Leak, Fire or Accident, Call 

TREC 1-800-424-9300.

ISOFETAMID

TURF FUNGICIDE 

ACTIVE INGREDIENT: Isofetamid* ................................... 36.0% OTHER INGREDIENTS: ...................................................... 64.0% Total ...................................................................................... 100.0% *N-[1,1-dimethyl-2-[2-methyl-4-(1-methylethoxy)phenyl]-2-oxoethyl]-3-methyl-2-thiophenecarboxamide Contains 3.33 pounds Isofetamid Per Gallon (400 grams per liter) KEEP OUT OF REACH OF CHILDREN CAUTIONSee side panel for additional precautionary statements. Read entire label carefully and use only as directed. ISK Biosciences Corporation 7470 Auburn Road, Suite A Concord, Ohio 44077 U.S.A. EPA Reg. No. 71512-EG EPA Est. No. Active Ingredient Made in Japan Formulation Made in Net Contents:

GROUP 7 FUNGICIDE 

07/21/2015

71512-23
 STATEMENTS 

S AND DOMESTIC ANIMALS 

CAUTION

bsorbed through skin. Avoid contact with 

Wash thoroughly with soap and water after 

, drinking, chewing gum, using tobacco or 

 and wash contaminated clothing before 

pment (PPE) 

dlers must wear long-sleeved shirt and long 

chemical resistant gloves made of any 

tructions for cleaning/ maintaining PPE. If 

ashables, use detergent and hot water. Keep 

rom other laundry. 

ements 

d systems, enclosed cabs, or aircraft in a 

quirements listed in the Worker Protection 

ltural pesticides [40 CFR 170.240(d)(4-6)], 

ments may be reduced or modified as 

ations 

ing, drinking, chewing gum, using tobacco 

immediately if pesticide gets inside. Then 

ut on clean clothing. 

tely after handling this product. Wash the 

e removing. As soon as possible, wash 

 into clean clothing.

ENVIRONMENTAL HAZARDS 

This pesticide is toxic to oysters. DO NOT apply directly to water, or to areas where surface water is present or to intertidal areas below the mean high water mark. DO NOT contaminate waters when disposing of equipment washwaters or rinsate. Do not apply when weather conditions favor drift from the treated areas. Drift and runoff may be hazardous to aquatic organisms in water adjacent to treated areas. AVOIDING SPRAY DRIFT AT THE APPLICATION SITE IS THE RESPONSIBILITY OF THE APPLICATOR. The interaction of many equipment-and-weather-related factors determine the potential for spray drift. The applicator is responsible for considering all these factors when making decisions. Where states have more stringent regulations, they must be observed. 

STORAGE AND DISPOSAL 

DO NOT contaminate water, food or feed by storage or disposal.PESTICIDE STORAGE: Store in original container, in a secured, dry, cool place separate from fertilizer, food, and feed. Avoid cross-contamination with other pesticides. PESTICIDE DISPOSAL: Pesticide wastes may be hazardous. Improper disposal of excess pesticide, spray mixture or rinsate is a violation of Federal law. If these wastes cannot be disposed of by use according to label instructions, contact your State Pesticide or Environmental Control Agency or the Hazardous Waste representative at the nearest EPA Regional Office for guidance. CONTAINER HANDLING: Nonrefillable container (equal to or less than 5 gallons). DO NOT reuse or refill this container. Triple rinse container (or equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents into application equipment or a mix tank and drain for 10 seconds after the flow begins to drip. Fill the container 1⁄4 full with water and recap. Shake for 10 seconds. Pour rinsate into application equipment or a mix tank or store rinsate for later use or disposal. Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more times. Then offer for recycling if available, or puncture and 
ndfill, or by incineration or, if allowed by 

by burning. If burned, stay out of smoke. 

reater than 5 gallons). DO NOT reuse or 

e rinse container (or equivalent) promptly 

nse as follows: Empty the remaining 

equipment or a mix tank. Fill the 

ter. Recap and tighten closures. Tip 

oll it back and forth, ensuring at least one 

0 seconds. Stand the container on its end 

ral times. Turn the container over onto its 

nd forth several times. Empty rinsate into 

 mix tank or store rinsate for later use or 

cedure two more times. Then offer for 

puncture and dispose of in a sanitary 

on or, if allowed by state and local 

burned, stay out of smoke. 

 USE 

al law to use this product in a manner 

ng. 

uct in a way that will contact workers or 

ectly or through drift. Only protected 

a during application. For any requirements 

Tribe, consult the agency responsible for 

W THE USE DIRECTIONS AND 

IS LABEL MAY RESULT IN PLANT 

ASE CONTROL. 

ble suspension concentrate for control of 

ociated with golf courses (greens, tees and 

d farms, college and professional sports 

mmercial lawns. Intended for use only by 

AGRICULTURAL USE REQUIREMENTS Use this product only in accordance with its labeling and with the 

Worker Protection Standard, 40 CFR Part 170. This Standard contains requirements for the protection of agricultural workers on farms, forests, nurseries, and greenhouses and handlers of agricultural pesticides. It contains requirements for training, decontamination, notification, and emergency assistance. It also contains specific instructions and exceptions pertaining to the statements on this label about personal protective equipment (PPE), and restricted-entry interval. The requirements in this box only apply to uses of this product that are covered by the Worker Protection Standard. DO NOT enter or allow worker entry into treated areas during the restricted entry interval (REI) of twelve (12) hours.PPE required for early entry into treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated, such as plants, soil, or water, is: coveralls, chemical resistant gloves made of any waterproof material, shoes plus socks. Sod and seed farms, commercial greenhouses and nurseries are within the scope of the Worker Protection Standard. NON-AGRICULTURAL USE REQUIREMENTS The requirements in this box apply to uses of this product that are not within the scope of the Worker Protection Standard for agricultural pesticides, 40 CFR Part 170. The WPS applies when this product is used to produce agricultural plants on farms, forests, nurseries, or greenhouses. Turfgrasses on golf courses and other non-residential turf areas such as industrial parks, tank farms, professionally managed college and professional sports fields, commercial lawns and ornamental landscapes are not within the scope of the Worker Protection Standard. Keep children, pets, and unprotected persons out of the treated area until sprays have dried. 
ION 

spectrum fungicide with preventative, 

erties for the control of dollar spot on 

D should be used in a regularly scheduled 

m and used in rotation with products with 

 such as triazoles, ergosterol biosynthesis 

dazoles. For control of other diseases 

OFETAMID may be tank mixed with 

xes should follow the use instructions on 

rate and application timings. Failure to 

ay results in inferior disease control 

as been evaluated on several turfgrass 

rids with no indication of phytotoxicity, 

or seller have determined adequate 

nder all conditions. The user should 

D can be used safely for commercial use 

e to a small test area under conditions to 

or adverse effects before applying 

ted area.

n 3.2 fl oz/1000 sq ft per year or 140 fl 

al to 8 applications at the low rate (0.452 

r 6 applications at the high rate (0.567 lb 

MID through any type of irrigation MID by aerial application 

y professional applicators. 

ANAGEMENT 

cellent disease control agent when used 

ons for control of dollar spot on turfgrass. 

has preventative, systemic and curative 

activity, it should be applied as a protectant fungicide before visible symptoms of the disease occur. Depending upon the level of disease pressure, good protection of the turfgrass can be expected over a period of 14 days. ISOFETAMID is recommended for use as part of an Integrated Pest Management (IPM) program, which may include the use of diseaseresistant crop varieties, cultural practices, biological disease control agents, pest scouting and disease forecasting systems aimed at preventing economic pest damage. Practices known to reduce disease development should be followed. Consult your state cooperative extension service or local agricultural authorities for additional IPM strategies established in your area. ISOFETAMID may be used in State Agricultural Extension advisory (disease forecasting) programs that recommend application timing based upon environmental factors that favor disease development.RESISTANCE MANAGEMENT Some plant pathogens are known to develop resistance to products used repeatedly for disease control. ISOFETAMID’s mode/target site of action is complex II; succinate-dehydrogenase, FRAC Group 7. A disease management program that includes alternation or tank mixes between ISOFETAMID and other labeled fungicides that have a different mode of action and/or control pathogens not controlled with ISOFETAMID is essential to prevent disease resistant pathogens populations from developing. ISOFETAMID should not be utilized continuously nor tank mixed with fungicides that have shown to have developed fungal resistance to the target disease. Since pathogens differ in their potential to develop resistance to fungicides, follow the directions outlined in the “Directions For Use” section of this label for specific resistance management strategies. Consult with your Federal or State Cooperative Extension Service representatives for guidance on the proper use of ISOFETAMID in programs that seek to minimize the occurrence of disease resistance. ISOFETAMID is not cross-
 of fungicides that have different modes 

NG 

OFETAMID should be applied prior to or 

disease development. ISOFETAMID 

l rates and timings listed in the 

in 2 to 4 gallons of water per 1000 

ons per acre). 

veral times to assure uniform mixture of 

g this product to the spray tank. The 

ETAMID 400SC should be added slowly 

filling. With concentrate sprays, pre-mix 

OFETAMID 400SC in a clean container 

s it is being filled. Keep agitator running 

nd during spray operations. DO NOT 

and overnight or for prolonged periods. 

 of spray required for immediate use. 

ld be thoroughly cleaned immediately 

le for disease development, the highest 

application interval should be used.

plied with all types of spray equipment 

applications on turfgrasses.

TANK MIX COMPATIBILITY ISOFETAMID is physically compatible (no nozzle or screen blockage) with many products labeled for control of diseases and insects on turfgrasses. Read and follow all manufacturers label precautions and restrictions for the tank mix companion product. It is the applicator’s responsibility to ensure that the companion product is EPA approved for use on the intended site. ISOFETAMID is generally compatible with other insecticides, fungicides, adjuvants, fertilizers and micronutrient products provided sufficient free water is available for dispersion of all the tank mix products. Under some conditions, the use of adjuvants and/or surfactants at the rate of 0.025% to 0.1% of the spray tank volume may improve the performance of ISOFETAMID. However, the physical compatibility of ISOFETMAID with tank mix partners must be evaluated before use. Conduct a jar test with intended tank-mix pesticides prior to preparation of large volumes. Use the following procedure: 1) Pour the recommended proportions of the products into a suitable container of water; 2) Mix thoroughly and; 3) Allow to stand for 5 minutes. If the combination remains mixed or can be re-mixed readily, it is considered physically compatible. Any physical incompatibility in the jar test indicates that ISOFETAMID should not be used in the tank-mix. User should note that not all turf varieties have been tested with all possible tank mix combinations. Thus the combination should be tested for turf safety on a small portion of the turf to ensure that a phytotoxic response will not occur. 
s and Intervals 

Rate 

(fl oz/1000 sq ft)

Rate

(fl oz / acre) 

Application 

Interval

(days)

Comments

)

0.4 to 0.5 17.4 to 21.8 

(0.452 to 

0.567 lb. 

a.i./A 

14 Apply as a preventative treatment prior to or in the very early 

stage of development. Use the highest rate during periods of prolonged favorable disease conditions. Do not apply more than two consecutive applications of ISOFETAMID or other Group 7 containing fungicides before rotating to a registered fungicide with a different mode of action. Do not apply the next application of ISOFETAMID within 28 days of the previous two consecutive ISOFETAMID applications. 

r Applications 

fl oz of ISOFETAMID per 100 gallons of spray solutions

Spray Volume 

2 gallons per 1000 sq ft 

Spray Volume 

3 gallons per 1000 sq ft 

Spray Volume 

4 gallons per 1000 sq ft 

20 fl oz/ 100 gal 13.3 fl oz/ 100 gal 10 fl oz/ 100 gal 25 fl oz/ 100 gal 16.7 fl oz/ 100 gal 12.5 fl oz/ 100 gal 

MITATION OF DAMAGES 

sons lawfully acquiring title to this product 

 of this product by Seller that this product 

description and was reasonably fit for the 

el when used in accordance with Seller’s 

ditions of use. To the extent consistent with 

users of this product assume the risk of any 

irections. EXCEPT AS PROVIDED 

TING CONTAINING AN EXPRESS 

WARRANTY AND LIMITATION OF 

KES NO OTHER EXPRESS OR 

IMPLIED WARRANTY OR GUARANTY, INCLUDING ANY OTHER EXPRESS OR IMPLIED WARRANTY OF FITNESS OR OF MERCHANTABILITY, AND NO AGENT OF SELLER IS AUTHORIZED TO DO SO. In no event shall Seller’s liability for any breach of warranty or guaranty exceed the purchase price of the product as to which a claim is made. To the extent consistent with applicable law, Buyers and users of this product are responsible for all loss or damage from use or handling of this product which results from conditions beyond the control of Seller, including, but not limited to, incompatibility with other products unless otherwise expressly provided in Directions for Use of this product, weather conditions, cultural practices, moisture conditions or other environmental conditions outside of the ranges that are generally recognized as being conducive to good agricultural and/or horticultural practices. 

ISOFETAMID - 03202015