# United States Chemical Safety June 2011

Environmental Protection and Pollution Prevention

Agency (7510P)



# Bronopol

Summary Document:

Registration Review : Initial Docket

June 2011

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3 

# TABLE OF CONTENTS

Bronopol Registration Review Team

................................ ................................ ................... 4

I. Preliminary Work Plan

................................ ................................ ................................ ..... 5

II. Fact Sheet

................................ ................................ ................................ ...................... 12

III. Summary of Anticipated Data Requirements

................................ .............................. 20

IV. Appendix A

................................ ................................ ................................ .................. 22

________________________________________

Please Note

This Preliminary Work Plan and Fact Sheet summarize the Environmental Protection Agency's

current position based on the following documents:

1. Summary of Product Chemistry, Environmental Fate, and Ecotoxicity Data for the

Bronopol Registration Review Decision Document

. April 25, 2011

2. 2

- Bromo

- 2

- nitropropane

- 1 ,3

- diol. Human Health Effects Scoping Document for the

Registration Review Decision

. April 19, 2011

Additional supporting documents for the Bronopol Case may be found in the registration review

docket EPA

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- 0421 located on the internet at www.regulations.gov

.

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4 Bronopol Registration Review Team

William Hazel Human Health & Environmental Effects

Srinivas Gowda

Eliza Blair Risk Management

Lance Wormell

Philip Ross Office of General Counsel

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5 I. Preliminary Work Plan

-- Bronopol

The Food Quality Protection Act (FQPA) of 1996 mandated a registration review program. All

pesticides distributed or sold in the United States generally must be registered by the U.S.

Environmental Protec tion Agency (USEPA, EPA, or the Agency) based on scientific data

showing that they will not cause unreasonable risks to human health or the environment when

used as directed on product labeling. The registration review program is intended to make sure

tha t, as the ability to assess risk evolves and as policies and practices change, all registered

pesticides continue to meet the statutory standard of no unreasonable adverse effects to human

health or the environment. Changes in science, public policy, and pesticide use practices will

occur over time. Through the registration review program, the Agency periodically reevaluates

pesticides to make sure that as change occurs, products in the marketplace can be used safely.

Information on this program is provi ded at Introduction:

http://www.epa.gov/oppsrrd1/registration_review/

.

The Agency is implementing the registration review program pursuant to Section 3(g) of the

Federal Insecticide, Fungicide, and Rodentici de Act (FIFRA) and will review each registered

pesticide every 15 years to determine whether it continues to meet the FIFRA standard for

registration. The Agency will consider benefits information and data as required by FIFRA. The

public phase of regist ration review begins when the initial docket is opened for each case. The

docket is the Agency’s opportunity to state what it knows about the pesticide and what additional

risk analyses and data or information it believes are needed to make a registration review

decision. After reviewing and responding to comments and data received in the docket during

this initial comment period, the Agency will develop and commit to a final work plan and

schedule for the Bronopol C ase.

The Bronopol case (Case 2770) cont ains one active ingredient, 2

- Bromo

- 2

- nitro

- 1,3

- propanediol

( Bronopol ) (PC Code 216400). The first product containing Bronopol as an active ingredient

was registered in the United States in 198 7

. Currently

, there are 42 product s registered with EPA.

Bronopol is a bacteriostat, fungicide, microbicide, microbiostat, antimicrobial, and algaecide

. Products containing bronopol are registered for use as a materials preservative, in industrial

process water systems, and in HVAC systems. It is registered fo r use to preserve adhesives,

metalworking fluids, absorbent clay, starch slurries, pigment slurries, mineral slurries, paints,

emulsion systems, water

- based printing inks and fountain solutions, paper, and bulk pulp. The

following water systems uses are r egistered : paper mill process water systems, recirculating

water cooling towers, evaporative condensers, air scrubber systems, air conditioning systems,

humidifying systems, oil and gas drilling fluids, and oil and gas pipeline maintenance. For

HVAC syst ems the following uses are registered : furnaces, air handlers, coils, fans, fan housings,

sheet metal ducts, air supply and return ducts, humidifiers, dehumidifiers, and air intake and

discharge devices. Bronopol has been widely used for decades as a pres ervative in

pharmaceuticals, cosmetics, and other personal care products regulated by the Food & Drug

Administration (FDA). Bronopol is exempt from the requirement of a tolerance when used at

≤400 ppm as an inert ingredient in conventional pesticide produ cts used on crops ( 40 CFR

§180.910 ) and animals ( 40 CFR § 180.93 0 )

.

The Agency completed a Reregistration Eligibility Decision (RED) for Bronopol in 1995

.

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6 Documents associated with the registration review of Bronopol can be viewed at

www.regulations.gov in docket EPA

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relevant to this registration review case.

EPA believes that Bronopol release s formaldehyde (HCHO) under certain conditions ; t herefore,

this Registration Review also addresses potential risks associated with formaldehyde exposure

from Bronopol use. Products containing formaldehyde as an active ingredient will be evaluated

under registration review Case 0556. EPA ’s formaldehyde RED is available in the formaldehyde

public docket at http://www.regulations.gov in docket number EPA

- HQ

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- 2008

- 0121.

The Agency anticipates the need to conduct a comprehensive ecological risk assessment,

including an endangered species risk assessment, for all uses of Bronopol. The Agency

anticipates the need to conduct a human health risk assessment. The Agency antici pates needing

additional data for use in the registration review for Bronopol. Anticipated Risk Assessment and Data Needs:

Ecological Risk:

**•** No recent ecological risk assessment has been performed for Bronopol

.

**•** The Agency has not conducted a risk assessment that supports a complete endangered

species determination for Bronopol

. The ecological risk assessment planned during

registration review will allow the Agency to determine whether Bronopol ’s use has 'no

effe ct' or 'may affect' federally listed threatened or endangered species (listed species) or

their designated critical habitats. When an assessment concludes that a pesticide’s use

'may affect' a listed species or its designated critical habitat, the Agency will consult with

the U.S. Fish and Wildlife Service and/or National Marine Fisheries Services (the

Services), as appropriate.

**•** The Agency anticipates the need to require the following addit ional ecological data for

use in the registration review of Bronopo l.

850.1300

-- Daphnid chronic toxicity test

850.1400

-- Fish early

- life stage toxicity test (freshwater)

850.4225

-- Seedling emergence, Tier II

- dose response study on rice (Oryza sativa);

850.4250

-- Vegetative vigor, Tier II

- dose response study on r ice (Oryza sativa);

850.4400

-- Aquatic plant growth (aquatic vascular plant toxicity), Tier II

- using

Lemna gibba, Tier I

850.5400

-- Aquatic plant growth (algal toxicity), Tier II

- dose response studies on

four species

**•** The Agency anticipates the need to require the following additional environmental fate

data f o r use in the registration review of Bronopol.

850.6800

-- Modified activated sludge, respiration inhibition test

835.3110

-- Ready Biodegradability

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7 835.3280

-- Simulation Tests to Assess the Bio degradability of Chemicals Discharged

to Wastewater

**•** F or more information

, please refer to Summary of Product Chemistry, Environmental

Fate, and Ecotoxicity Data for the Bronopol Registration Review Decision Document

, located in the docket

.

Human Health Ri sk:

**•** No recent human health risk assessment has been performed for Bronopol

. The Agency

anticipates the need to require the following additional human health data for use in the

registration review of Bronopol.

870.3465

-- 90

- day inhalation toxicity (rat)

875.1700

-- Product use information (outdoor)

875.2700

-- Product use information (indoor)

875.2800

-- Description of human activity

875.1100

-- Dermal outdoor exposure

875.1200

-- Dermal indoor exposure

875.1300

-- Inhalation outdoor exposure

875.14 00

-- Inhalation indoor exposure

875.1600

-- Application exposure data reporting and calculations

875.2900

-- Data reporting and calculations

**•** F or more information

, please refer to 2

- Bromo

- 2

- nitropropane

- 1,3

- diol. Human Health

Effects Scoping Document for the Registration Review Decision

, located in the docket

.

Product Chemistry:

**•** The Agency does not anticipate the need to require additional product chemistry data for

use in the registration review at this time.

**•** F or more information

, please refer to Summary of Product Chemistry, Environmental

Fate, and Ecotoxicity Data for the Bronopol Registration Review Decision Document

, located in the docket

.

As required by FIFRA and FFDCA, EPA reviews numerous studies to assess potential adverse

outcomes from exposure to chemicals. Collectively, these studies include acute, subchronic and

chronic toxicity, including assessments of carcinogenicity, neurotoxici ty, developmental,

reproductive, and general or systemic toxicity. These studies include endpoints which may be

susceptible to endocrine influence, including effects on endocrine target organ histopathology,

organ weights, estrus cyclicity, sexual maturati on, fertility, pregnancy rates, reproductive loss,

and sex ratios in offspring. For ecological hazard assessments, EPA evaluates acute tests and

chronic studies that assess growth, developmental and reproductive effects in different

taxonomic groups. As part of its most recent registration decision , EPA reviewed these data and Endocrine Disruptor Screening Program

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8 selected the most sensitive endpoints for relevant risk assessment scenarios from the existing

hazard database. However, as required by FFDCA section 408(p), Bronopol is subject to the

endocrine screening part of the Endocrine Disruptor Screening Program (EDSP).

EPA has developed the EDSP to determine whether certain substances (including pesticide

active and other ingredients) may have an effect in humans or wildlife similar to an effect

produced by a “naturally occurring estrogen, or other such endocrine effects as the Administrator

may designate.” The EDSP employs a two

- tiered approach to making the statutorily required

determinations. Tier 1 consists of a battery of 11 screenin g assays to identify the potential of a

chemical substance to interact with the estrogen, androgen, or thyroid (E, A, or T) hormonal

systems. Chemicals that go through Tier 1 screening and are found to have the potential to

interact with E, A, or T hormon al systems will proceed to the next stage of the EDSP where EPA

will determine which, if any, of the Tier 2 tests are necessary based on the available data. Tier 2

testing is designed to identify any adverse endocrine

- related effects caused by the substanc e, and

establish a dose

- response relationship between the dose and the E, A, or T effect.

Under FFDCA section 408(p), the Agency must screen all pesticide chemicals. Between

October 2009 and February 2010, EPA issued test orders/data call

- ins for the firs t group of 67

chemicals, which contains 58 pesticide active ingredients and 9 inert ingredients. Bronopol is

not among the group of 58 pesticide active ingredients on the initial list to be screened under the

EDSP. Accordingly, as part of registration re view, EPA will issue future EDSP orders/data call

ins, requiring the submission of EDSP screening assays for Bronopol

. For further information on

the status of the EDSP, the policies and procedures, the list of 67 chemicals, future lists, the test

guideli nes and the Tier 1 screening battery, please visit our website: http://www.epa.gov/endo/

.

EPA has created the following estimated timeline for the completion of the Bronopol registration

review: Timeline

Anticipated Schedule

Activities Estimated Month/Year

Phase 1: Opening the docket

Open Public Comment Period for Docket June 2011

Close Public Comment Period for Docket August 2011

Phase 2: Case Development

Develop Final Work Plan (FWP) December 2011

Issue DCI December 2012

Data Submission December 2014

Open Public Comment Period for Preliminary Risk Assessments June 2016

Close Public Comment Period for Preliminary Risk Assessments August 2016

Phase 3: Registration Review Decision

Open Public Comment Period for Proposed Reg. Review Decision December 2016

Close Public Comment Period for Proposed Reg. Review Decision February 2017

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9 Final Decision and Begin Post

- Decision Follow

- up 2017

Total (years) 5.5

The public is invited to comment on EPA’s P reliminary W ork P lan and rationale. The Agency

will carefully consider all comments as well as any additional information or data provided in a

timely manner prior to issuing a final work plan for the Bronopol registration review case. Guidance for Commenters:

Through the registration review process, the Agency intends to solicit information on trade

irritants and, to the extent feasible, take steps toward facilitating irritant resolution. Growers and

other stakeholde rs are asked to comment on any trade irritant issues resulting from lack of

Maximum Residue Limits (MRLs) or disparities between U.S. tolerances and MRLs in key

export markets, providing as much specificity as possible regarding the nature of the concern. Trade Irritants:

Bronopol is not identified as a cause of impairment for any water bodies listed as impaired

under section 303(d) of the Clean Water Act, based on information provided at Water Quality:

http://iaspub.epa.gov/tmdl_waters10/attains_nation_cy.cause_detail_30 3d?p_cause_group_id=88

5 . In addition, no Total Maximum Daily Loads (TMDL) have been developed for Bronopol

, based on information provided at

http://iaspub.epa.gov/tmdl_waters10/attains_nation.tmdl_pollutant_detail?p_pollutant_group_id

=885&p_pollutant_grou p_name=PESTICIDES

More information on impaired water bodies and TMDLs can be found at .

http://www.epa.gov/owow/tmdl/ . The Agency invites submission of water quality data for this

pesticide. To the extent possib le, data should conform to the quality standards in Appendix A of

the OPP Standard Operating Procedure: Inclusion of Impaired Water Body and Other Water

Quality Data in OPP’s Registration Review Risk Assessment and Management Process (see:

http://www.epa.gov/oppsrrd1/registration_review/water_quality_sop.htm ), in order to ensure the

data can be used quantitatively or qualitatively in pesticide risk assessments.

EPA seeks to achieve environmental justice, the fair treatment and meaningful involvement of all

people, regardless of race, color, national origin, or income, in the development, implementation,

and enforcement of environmental laws, regulations , and policies. To help address potential

environmental justice issues, the Agency seeks information on any groups or segments of the

population who, as a result of their location, cultural practices, or other factors, may have

atypical, unusually high exp osure to Bronopol compare d to the general population. Please

comment if you are aware of any sub

- populations that may have atypical, unusually high

exposure compared to the general population. Environmental Justice:

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10 EPA must rely upon information of appropriate quality and reliability for each decision made by

the Agency. In the Office of Pesticide Programs (OPP), the evaluation process for a pesticide

chemical traditionally begins with the applicant’s submission of a set of studies conducted with

the specific pesticide chemical of interest. The use of the results of such testing (measured data)

is a logical, scientifically rigorous process that identifies the physical, chemical, and

environmental fate properties of the pesticide, as well as the dose and endpoints at which an

adverse effect can occur in various animal species. Structure Activity Relationships:

Today, there is significant interest in alternative techniques, i.e., techniques other than data

generation that could significantly inform th e Agency’s decision

- making process. Recently,

OPP has made increasing use of structure activity relationship (SAR) as part of its regulatory

decision

- making process. In the SAR process, a chemical's molecular structure is compared to

that of other chemic als for which data are available. These structural similarities are then used to

make predictive judgments about a chemical’s physical, chemical, and biological properties.

Thus, the chemical’s physical, chemical, and biological properties are a function of (or directly

related to) the chemical’s molecular structure. Quantitative SAR is referred to as QSAR. To

develop a QSAR, a selected set of measured data on a single physical, chemical, or biological

property is used to derive a model (an equation) to predict the value of that property.

Since SAR assessments and QSAR modeling are another set of tools that are available to Agency

scientists, OPP has begun a process shift that envisions shifting from the current study

- by

- study

approach to an approach i n which the use of predicted data, generated using validated models, is

considered along with information from open literature and studies specifically generated under

Part 161 requirements. All relevant information would be considered as part of a weight

- of

- the

evidence evaluation.

At this time, EPA believes that for certain endpoints, especially physical/chemical and fate

properties, that SAR and QSAR might be effectively utilized to fulfill these data requirements

for many antimicrobial pesticide chem icals. When considering biological properties, at this

time, EPA believes that SAR and QSAR can be most effectively utilized in the evaluation of

chemicals that exhibit lower toxicity for human health and/or ecotoxicity parameters. This is

appropriate be cause the risk assessment for lower toxicity chemicals can be stream

- lined, i.e., a

screening

- level assessment procedure rather than multiple tiers of assessments with progressively

more data requirements.

If stakeholders believe that submission of predict ed data can fulfill one of the data needs for the

Bronopol c ase, then the Agency invites submission of this information. The submitter would be

expected to supply a rationale describing the utility of the information and provide

documentation on the scien tific validity of the information. The determination that the predicted

data fulfills the data requirement would be at the sole discretion of the Agency. Pre

- submission

consultation with the Agency is encouraged.

Additional Information:

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11 Stakeholders are also specifically asked to provide available information and data that will assist

the Agency in refining its risk assessments , including any species

- specific ecological effects

determinations . The Agency is interested in receiving the following information:

1. Confirmation on the following label information:

a. Sites of application

b. Formulations

c. Application methods and equipment

d. Maximum application rates

e. Frequency of application, application intervals and maximum number of

applications

f. Geographic limita tions on use

2. Use or potential use distribution

3. Use history

4. Usage/use information for non

- agricultural uses (e.g., materials preservation)

5. Typical application interval

6. State or local use restrictions

7. Ecological incidents (non

- target plant damage and avian, fish, reptilian, amphibian

and mammalian mortalities) not already reported to the Agency

8. Monitoring data

Next Steps:

After the 60

- day comment period closes in August 2011 , the Agency will review and respond to

any comments received in a timely manner, and then issue a Final Work Plan for the Bronopol

C ase.

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12 II. Fact Sheet

**•** Active Ingredient: 2

- Bromo

- 2

- nitro

- 1,3

- propanediol ( Bronopol ) Background Information:

**•** C ase number: 2770

**•** PC Code: 216400

**•** CAS number : 52

- 51

- 7

**•** Technical registrants: Dow Chemical, BASF Corporation, Lanxess

**•** First approved for use in a registered product: 1984

**•** Bronopol is exempt from the requirement of a tolerance when used at ≤400 ppm as an

inert ingredient in conventional pesticide products used on crops ( 40 CFR §180.910 ) and

animals ( 40 CFR § 180.93 0 )

.

**•** Antimicrobials Division Chemical Review Manager (CRM): Eliza Blair

, blair.eliza@epa.gov

**•** Antimicrobials Division Product Manager (PM): Marshall Swindell

, swindell.marshall@epa.gov

**•** Chemical Structure:

**•** Bronopol is a bacteriostat, fungicide, microbicide, microbiostat, antimicrobial, and

algaecide . Bronopol is registered for use as a materials preservative, in industrial process

water systems, and in HVAC systems. It is registered for use to preserve adhesives,

metalworking fluids, absorbent clay, starch slurries, pigment slurries, mineral slurries,

paints, emulsion systems, wa ter

- based printing inks and fountain solutions, paper, and

bulk pulp. The following water systems uses are registered : paper mill process water

systems, recirculating water cooling towers, evaporative condensers, air scrubber

systems, air conditioning sy stems, humidifying systems, oil and gas drilling fluids, and

oil and gas pipeline maintenance. For HVAC systems the following uses are registered :

furnaces, air handlers, coils, fans, fan housings, sheet metal ducts, air supply and return

ducts, humidifie rs, dehumidifiers, and air intake and discharge devices. Bronopol has

been widely used for decades as a preservative in pharmaceuticals, cosmetics, and other

personal care products regulated by the Food & Drug Administration (FDA). Use & Usage Information:

**•** On November 9, 2005, the Agency issued a ruling exempting Bronopol from the

requirement of a tolerance when used as an inert ingredient in

- can preservative at ≤400

ppm when applied to growing crops or to raw agricultural commodities after harve st

under 40 CFR 180.910, and when applied to animals under 40 CFR 180.930. This ruling Recent/Pending Regulato ry Actions :

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13 was a response to a tolerance exemption petition filed by BASF Corporation and

announced in the Federal Register on December 24, 2002.

Please refer to Summary of Product Chemistry, Environmental Fate, and Ecotoxicity Data for

the Bronopol Registration Review Decision Document , located in the docket, for a detailed

discussion of the ecological risk assessments. Ecological Risk Assessment Status:

**•** No recent ecological risk assessment has been performed for Bronopol because minimial

environmental exposure was expected based on the uses registered at that time

.

**•** Bronopol uses registered after the RED that have potential for environmental exposure

are material s preservatives and industrial slimicides used in recirculating water cooling

towers and paper mills discharges.

**•** The Agency has not conducted a risk assessment for Bronopol that supports a complete

endangered species effects determination. The ecological risk assessment planned during

registration review will allow the Agency to determine whether Bronopol ’s use has “no

effect or “may affect” federally listed threatened or endangered species (listed species) or

their designed critical habitats. When an as sessment concludes that a pesticide’s use

“may affect” a listed species or its designated critical habitat, the Agency will consult

with the U.S. Fish and Wildlife Service and/or National Marine Fisheries Services (the

Services), as appropriate.

**•** No recent environmental fate assessment has been performed for Bronopol

.

The most recent human health risk assessment for Bronopol was conducted for the 1995

Reregistration Eligibility Decision (RED). Human Health Risk Assessment Status:

The following are key find ings of the recent human health risk assessments for Bronopol . Please

refer to 2

- Bromo

- 2

- nitropropane

- 1,3

- diol. Human Health Effects Scoping Document for the

Registration Review Decision

, located in the docket, for a detailed discussion of the human

healt h risk assessment.

Hazard Characterization:

**•** Formaldehyde may be released from Bronopol under certain conditions , though it does

not appear to be Bronopol’s main mechanism of antimicrobial action

. The Agency

anticipates the need for further data to determine the conditions and extent of this release.

The hazard database for formaldehyde is adequate as discussed in the 2008

Formaldehyde Reregistration Eligibility Decision document. However, the toxicity

endpoints for use in risk assessment remain the subject of much public discussion and

scientific evaluation by a number of EPA offices, industry groups, scholars, and other

government agencies. These official endpoints may be subject to change before, during or

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14 after the Registration Review risk as sessment for Bronopol; the Agency will assess

formaldehyde risks based on the most up

- to

- date official endpoints available at the time.

Dietary (Food and Water):

**•** A dietary risk assessment was conducted in 2005 to support the exemption from the

requirement of a tolerance when used at rates 

# ≤ 400 ppm on crops and animals. At that time

and using conservative assumptions, the Agency determined that this use would result in

dietary exposure below levels of concern.



# • Dietary (food) exposure could also potentially occur because Bronopol is used as an in

can preservative or preservative during storage or use of materials including the

following: bulk paper pulp, paper and paperboard water systems, water

- based coatings,

dishwashing liquids, and premoisten ed sponges and wipes. Residue transfer from these

preserved materials to food may occur. The labels do not preclude food contact use of

these materials; thus, a dietary assessment is now needed to characterize these exposures.

Residential:

**•** A residential risk assessment was not condu cted for the 1995 RED ; residential exposure to

products containing Br onopol was considered minimal due to standard exposure assumptions

at the time

.



# • Bronopol is intended for industrial materials preservative and water antifo ulant use only.

However, many of the materials preserved with Bronopol are intended for residential,

commercial, and institutional use and may result in exposure of the general public and

homeowners to the parent compound and formaldehyde . Such materials include latex

paints, resin/latex/polymer emulsions, or detergent and polish suspensions. However, to

determine whether residential or other nonoccupational exposure to the parent compound

or formaldehyde is likely to occur from its use as a preservative , data is needed, including

detailed information on physical and chemical properties and use information

, to

elucidate the conditions, rates, and magnitude of formaldehyde release from Bronopol

under various conditions and in various materials. To estimat e the extent that the parent

compound remains and the levels of formaldehyde released into the air from preserved

materials, small chamber studies are needed to better estimate potential residential

exposure. This will include a residential painter study.

Aggregate:

**•** The Agency has not conducted an aggregate risk assessment for Bronopol

.



# • In examining aggregate exposure, EPA takes into account the available and reliable

information concerning exposures to pesticide residues in food and drinking water, as

well as non

- occupational pesticide exposures. Dietary (food) exposure will potentially

occur from registered uses of Bronopol

. Bronopol residues may also reach drinking

water as a result of industrial discharges. However, the potential for contamination of

drinking water will be revisited upon receipt of biodegradability data as detailed below in

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15 “Summary of Anticipated Data Requirements”

. Residential painter and postapplication

exposure of adults and children to a large number of Bronopol

- preserved home owner

products are likely to occur. The specifics of necessary aggregate assessments will be

determined during the risk assessment stage of Registration Review.

Occupational:

**•** For the 1995 RED, an occupational assessment was conducted which examined handle rs’

mixing and loading exposure to Bronopol. At the time, risks were considered mitigated by

mandating the use of personal protective equipment (PPE) for some occupational uses and

closed loading such as by a metering pump for others. However, post

- applica tion exposures,

as to Bronopol

- containing paint, were not examined due to standard exposure assumptions at

the time. The Agency now needs to examine these exposures as part of a comprehensive risk

assessment for registration review

.



# • Bronopol products are a dded to preserve industrial materials during the manufacturing

process using open

- pour or metered pump application methods. During these processes,

dermal exposure to workers is expected, especially when open

- pour application is used.

Further, Bronopol h ydrolyzes to release formaldehyde which poses worker inhalation

exposure concerns. Use of a metered pump is expected to reduce both dermal and

inhalation exposures to formaldehyde . However, since the conditions under which

Bronopol releases formaldehyde and the rate of release are unknown, the Agency cannot

reliably estimate exposure to either the parent compound or formaldehyde . The major

occupational exposures are likely to be inhalation of Bronopol and formaldehyde and

dermal exposure to the parent co mpound, Bronopol. To determine exposure to

formaldehyde associated with each occupational scenario, detailed information are

needed on physical and chemical properties and use information to elucidate the

conditions (pH, temperature, etc.), rates, and mag nitude of formaldehyde release from

Bronopol under various conditions and in va rious materials (EPA Guidelines 875.1700

and 875.2700 , Indoor and Outdoor Product Use Information ). Small chamber studies are

anticipated to be needed to estimate the magnitude of occupational (mixer/loader)

formaldehyde inhalation exposure while preserving materials in the manufacturing

facility, using treated metalworking fluids, paper and paperboard mill water systems,

painting with preserved paint, an d applying preserved coatings. Additionally,

p ostapplication/bystander formaldehyde exposure data are needed to assess inhalation

risks posed to workers in pulp and paper mills, machine shops, and other industrial

facilities manufacturing preserved materials.

Cumulative:

**•** EPA d oes not have, at this time, available data to determine whether Bronopol has a

common mechanism of toxicity with other substances or how to include this pesticide in

a cumulative risk assessment. For the purposes of this Registration Review, EPA has

assume d that Bronopol does not have a common mechanism of toxicity with other

substances when used as an antimicrobial as registered.

Incidents:

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16 Ecological:

**•** No Bronopol ecological incidents have been reported in the OPP incident database.

Human Health:

**•** Four human poisoning incidents reported in the OPP incident database have been

confirmed as being due to Bronopol exposure. These are summarized as follows:

o A residential use of a Bronopol product to treat HVAC ducts resulted in the

homeowner becoming si ck. No more detailed information was provided.

o A worker was splashed on the upper arm with approximately 2 ml of a 25%

solution of Bronopol in water. The worker promptly washed the area with soap

and water. The worker experienced no immediate pain. The exposed area began

to itch later that evening and then blister. The worker went to a doctor who said it

was a second degree burn.

o A worker who uses a printing press claims development of a chemical allergy to

Bronopol

.

o A man reported that he was sick after the HVAC system in his house was treated

with a Bronopol product. The person began having some adverse reactions to the

chemical treatment immediately after re

- entering the house. The reactions

became more intense un til he finally had to leave the house.

Tolerances and International Harmonization:

**•** Bronopol is exempt from the requirement of a tolerance when used at ≤400 ppm as an

inert ingredient in conventional pesticide products used on crops ( 40 CFR §180.910 ) and

animals ( 40 CFR § 180.93 0 )

**•** No recent data call

- in has been issued for Bronopol. Since the Agency granted the

tolerance exemption in 2005 , several human health studies have been voluntarily

submitted; these will be fully evaluated for t he risk assessment portion of registration

review. Data Call

- In Status:

Labels:

Registered products, including EPA registration numbers are provided in Table 1 below. For

future reference, during registration review a list of product registration numbers will be included

in the docket. Product registration labels may be obtained from the Pesticide Product Label

System (PPLS) website at: http://oaspub.epa.gov/pestlabl/ppls.home

.

Table 1. Registered Products

– Bronopol

# Docket Number: EPA

- HQ

- OPP

- 2011

- 0421

www.regulations.gov

17 Registration # Registration Name Company Name Formulation

Type % of Active

Ingredient

464

- 675 BiobanTM BP

- Plus

Preservative The Dow Chemical Co. Ready

- to

- Use

Solution 99

464

- 676 Bioban BP

- 40

Preservative The Dow Chemical Co. Ready

- to

- Use

Solution 40.8

464

- 680 Bioban BP

- 10

Preservative The Dow Chemical Co. Ready

- to

- Use

Solution 10

464

- 685 Bioban BP 30

Preservative The Dow Chemical Co. Ready

- to

- Use

Solution 30

464

- 687 Bioban BP

- M

Preservative The Dow Chemical Co. Technical

Chemical 99

707

- 295 ROCIMATM 607 Rohm & Haas Co. Ready

- to

- Use

Solution 10

707

- 315 ROCIMATM 586 Rohm & Haas Co. Soluble

Concentrate 7.5

1258

- 1290 Proxel BN Preservative Arch Chemicals, Inc. Soluble

Concentrate 6.5

1529

- 58 Nuosept W International Specialty

Products Flowable

Concentrate 7

1529

- 59 Nuosept W Concentrate International Specialty

Products Soluble

Concentrate 14

3876

- 147 S3876 DE

- 1220 GE Betz, Inc. Ready

- to

- Use

Solution 5.3

3876

- 151 Betz ® 

# DE

- 5556 GE Betz, Inc. Ready

- to

- Use

Solution 5.3

5383

- 106 Mergal K12N Troy Chemical Corp Ready

- to

- Use

Solution 7.1

9386

- 45 AMA ®



# - 4900B Kemira Chemicals, Inc, Ready

- to

- Use

Solution 10

10707

- 53 X

- CIDE ® 

# 600 Industrial

Microbiocide Baker Petrolite Corporation Water Soluble

Packaging 98.45

33753

- 3 Myacide AS BASF Corporation Technical

Chemical 99

33753

- 5 Myacide AS Plus BASF Corporation Crystalline 99

33753

- 7 Myacide S2 BASF Corporation Ready

- to

- Use

Solution 40.8

33753

- 17 Myacide S15 BASF Corporation Ready

- to

- Use

Solution 10

# Docket Number: EPA

- HQ

- OPP

- 2011

- 0421

www.regulations.gov

18 Registration # Registration Name Company Name Formulation

Type % of Active

Ingredient

33753

- 18 2K7 Bugstick BASF Corporation Pelleted/Tableted 84.5

33753

- 20 Myacide S30 BASF Corporation Ready

- to

- Use

Solution 30

39967

- 28 Biochek 721M LANXESS Corporation Ready

- to

- Use

Solution 6

39967

- 59 Preventol P 100 LANXESS Corporation Technical

Chemical 99.74

39967

- 61 Preventol P 100

Preservative LANXESS Corporation Soluble

Concentrate 99.74

39967

- 64 Preventol P 30 LANXESS Corporation Soluble

Concentrate 30

39967

- 79 Preventol P 91 LANXESS Corporation Emulsifiable

Concentrate 9.97

49403

- 33 Nipacide GSF

- A Clariant Corporation Ready

- to

- Use

Solution 5.35

67071

- 16 Acticide LA Thor GmbH Ready

- to

- Use

Solution 8.8

67071

- 18 Acticide SR 2060 Thor GmbH Ready

- to

- Use

Solution 5.2

67071

- 45 Acticide MBL 5515 Thor GmbH Soluble

Concentrate 15

67071

- 46 Acticide MBL Thor GmbH Ready

- to

- Use

Solution 8

67071

- 50 Acticide LA 2605

- F Thor GmbH Soluble

Concentrate 5.3

67071

- 52 Acticide MBL 5505 Thor GmbH Soluble

Concentrate 5

67212

- 1 BBJ Microbiocide BBJ Environmental, LLC Ready

- to

- Use

Solution 95

67212

- 2 BBJ Maintain C

- 1 For

Floors And Walls BBJ Environmental, LLC Soluble

Concentrate 3.25

67212

- 3 BBJ Mold Control BBJ Environmental, LLC Ready

- to

- Use

Solution .05

67420

- 1 2K7 Bugstick OSP Microcheck Inc Water Soluble

Packaging 84.5

67420

- 2 2K7 Water Soluble Paks OSP Microcheck Inc Crystalline 99

67869

- 37 Vericide Bronopol Verichem, Inc. Crystalline 99

# Docket Number: EPA

- HQ

- OPP

- 2011

- 0421

www.regulations.gov

19 Registration # Registration Name Company Name Formulation

Type % of Active

Ingredient

67869

- 38 Vericide Bronopol

Solution Verichem, Inc. Soluble

Concentrate 10

68708

- 9 EC9086A Nalco Company Ready

- to

- Use

Solution 8.8

74655

- 14 Spectrum RX

- 96 Hercules Incorporated Ready

- to

- Use

Solution 5.3

# Docket Number: EPA

- HQ

- OPP

- 2011

- 0421

www.regulations.gov

20 III. Summary of Anticipated Data Requirements

– Bronopol

The table below summarizes anticipated data needs for the Bronopol c ase in Section I of this

document (Preliminary Work Plan), Summary of Product Chemistry, Environmental Fate, and

Ecotoxicity Data for the Bronopol Registration Rev iew Decision Document , and 2

- Bromo

- 2

- nitropropane

- 1,3

- diol. Human Health Effects Scoping Document for the Registration Review

Decision

.

Table 2. Summary of Anticipated Data Requirements

– Bronopol

Guideline

Number Anticipated Data Requirement Test Material Estimated Timeframe

(Measured in months from

DCI Receipt)

* 835.3110 Ready Biodegradability TGAI 24

* 835.3220 Porous Pot Test TGAI 24

*835.3280 Simulation Tests to Assess the

Biodegradability of Chemicals

Discharged to Wastewater TGAI 24

850.6800 Modified Activated Sludge Respiration

Inhibition TGAI 12

850.1300 Daphnid Acute Toxicity TGAI 24

850.1400 Fish Early

- Life Stage Toxicity TGAI 12

850.4225 Seedling Emergence, Tier II

– dose

response study on rice ( Oryza sativa ) TGAI 12

850.4250 Vegetative Vigor, Tier II

– dose response

study on rice ( Oryza sativa ) TGAI 12

850.4400 Aquatic Plant Growth (aquatic vascular

plant toxicity, Tier II

– dose response

study on floating macrophyte Lemna

gibba ) TGAI 12

850.5400 Aquatic Plant Growth (algal toxicity, Tier

II

– dose response studies on Selenastrum

capricornutum (green alga), Anabaena

flos

- aquae (blue

- green cyanobacteria),

Navicula pelliculosa (freshwater diatom),

and Skeletonema costatum (marine

diatom ). TGAI 12

870.3465 90

- Day Inhalation Toxicity (Rats) TGAI 24

875.1100 Dermal Exposure

– Outdoor TGAI 24

875.1200 Dermal Exposure

– Indoor TGAI 24

875.1300 Inhalation Exposure

– Outdoor TGAI 24

875.1400 Inhalation Exposure

– Indoor TGAI 24

# Docket Number: EPA

- HQ

- OPP

- 2011

- 0421

www.regulations.gov

21 875.1600 Application Exposure Monitoring Data

Reporting for Dermal and Inhalation Data TGAI 12

875.1700 Product Use Information

– Outdoor TGAI 12

875.2700 Product Use Information

– Indoor TGAI 12

875.2800 Description of Human Activity TGAI 12

875.2900 Data Reporting and Calculations TGAI 24

* 

# The results of the Activated Sludge Respiration Inhibition Test (ASRI) determine which of these biodegradation

tests would be expected to be required. If the ASRI test EC 50 

# is less than or equal to 20 mg/L, then either the

Biodegradation in Activated Sludge Study or the Porous Pot Test would be expected to be required. If the ASRI test

EC 50 

# is greater than 20 mg/L, then the applicant would choose either: (i) Ready Biodegrad ability or (ii)

Biodegradation in Activated Sludge or the Porous Pot Test. If the antimicrobial passes the ready biodegradability

study, then no further testing would be expected to be required. If, however, the antimicrobial fails the ready

biodegradabi lity study, then the Biodegradation in Activated Sludge or the Porous Pot study would be expected to

be required.2770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 464-675SolubleConcentrate 6.65Medical Premisesand EquipmentMedical Institutions,premises and equipmentHard, inanimate, nonporous surfacessuch as walls, floors, door handles,medical bed surfaces, bed frames,mattress springs, wheelchairs, lightswitches, linen carts, stretcherwheels, hampers, telephones,cleanup carts, bassinets, dressingSpray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-675SolubleConcentrate 6.65Medical Premisesand EquipmentDental Premises andequipmentdental mixing spatulas, equipmenttrays, dental operating light fixturesand handles, instrument controlpanels, extra oral orthodonticheadgears, orthodontic plasticbrackets, and other non-critical, hard,nonporous, inanimate surfacesSpray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-675SolubleConcentrate 6.65Medical Premisesand EquipmentDental Premises andequipmentUltrasonic cleaner concentrate Immersion 1/8 oz. per quart ofwater216400 464-675SolubleConcentrate 6.65Medical Premisesand EquipmentHair Salons Nippers, brushes, combs, rollers,tweezers, razors, clipper blades,manicure, pedicure, and otherimplements commonly found insalons, including most plastics.Immersion 1/8 oz. per quart ofwater. 10 minutecontact time.Agriculturalpremises andequipmentPoultry Premises andEquipmentFloors, walls, and equipment,including incubators, hatchers,setters, trays, racks, carts, sexingtables, delivery trucks, troughs, rack,feeding and watering bins, bucketsand fountains incubators VehiclesSpray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-675SolubleConcentrate 6.65andfountains. ,incubators.Vehiclesincluding mats, crates, cabs andwheels.216400 464-675SolubleConcentrate 6.65Agriculturalpremises andequipmentPoultry Premises andEquipmentHatchery rooms Fog 1/2 gallon per 2.5gallons of water. Fogone minute for every4000 cu. Ft.Preclean premises and close off area to be treated.Do not allow people to contact or breathe fog. Donot enter until product has settled. Ventilate areasthoroughly.216400 464-675SolubleConcentrate 6.65Agriculturalpremises andequipmentPoultry Premises andEquipmentIncubators and hatchers Fog 6 oz per 122 oz ofwater, fog 3-8 oz intosetters and hatchers.Repeat daily in settersand every 12 hours inhatchers. Do not usefor at least 24 hours1/2 oz per gallon of water of water maybe usedhourly or every other hour. Fog for 30-90 seconds.Do not allow people to contact or breathe fog. Donot enter until product has settled (30-60 minutes ).Ventilate areas thoroughly.216400 464-675SolubleConcentrate 6.65Agriculturalpremises andequipmentShoe Baths Entrances to buildings and livestockhousing areas.Spray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-675SolubleConcentrate 6.65Residential andpublic accesspremisesday care facilities, schools,hotels, motels, restaurants,Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.12770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 464-675SolubleConcentrate 6.65Residential andpublic accesspremisesDog and Cat Kennels Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-675SolubleConcentrate 6.65Medical Premisesand EquipmentVeterinary hospitals,clinics, premises andequipmentInstrument trays, operating tables,and other hard, nonporous premisesand surfaces, including, walls andfloors.Spray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-675SolubleConcentrate 6.65Agriculturalpremises andequipmentCattle farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates, cabs and wheels. Halters,ropes and other types of equipmentSpray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-675SolubleConcentrate 6.65Agriculturalpremises andequipmentSwine farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates cabs and wheels HaltersSpray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-675SolubleConcentrate 6.65Agriculturalpremises andequipmentHorse Stables Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-675SolubleConcentrate 6.65Agriculturalpremises andequipmentFarm premises andequipmentHard non porous areas, including,walls, floors and premisesFog 1 part to two partswater. Use onegallon per 6000-8000cu. Ft.Preclean premises and close off area to be treated.Do not allow people to contact or breathe fog. Donot enter until product has settled. Ventilate areasthoroughly.216400 464-675SolubleConcentrate 6.65Agriculturalpremises andequipmentGreenhouses, aquacultureareasTools, equipment, potting areas,headhouses, dry storage areas,automated potting machinery andhard non porous areas, including,walls floors and premisesSpray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.Agriculturalpremises andMushroom Houses Tools, equipment, breezeways, trackalleys before spawning inside andSpray, mop, wipe 1/2-1 oz. per gallon ofwater wet surface 10216400 464-675SolubleConcentrate 6.65premisesandequipmentalleysbeforespawning,insideandoutside walls of mushroom houses,lofts, floors, storage sheds, spawningmachines tampers and casing ringswater,wetsurface.10minute contact time.216400 464-476SolubleConcentrate 5.32Medical Premisesand EquipmentMedical Institutions,premises and equipmentHard, inanimate, nonporous surfacessuch as walls, floors, door handles,medical bed surfaces, bed frames,mattress springs, wheelchairs, lightswitches, linen carts, stretcherwheels, hampers, telephones,cleanup carts, bassinets, dressingSpray, mop, wipe 1-2 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-476SolubleConcentrate 5.32Medical Premisesand EquipmentDental Premises andequipmentdental mixing spatulas, equipmenttrays, dental operating light fixturesand handles, instrument controlpanels, extra oral orthodonticheadgears, orthodontic plasticbrackets, and other non-critical, hard,nonporous, inanimate surfacesSpray, mop, wipe 1-2 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-476SolubleConcentrate 5.32Medical Premisesand EquipmentHair Salons Nippers, brushes, combs, rollers,tweezers, razors, clipper blades,manicure, pedicure, and otherimplements commonly found insalons, including most plastics.Immersion 1/4 oz. per quart ofwater. 10 minutecontact time.22770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 464-476SolubleConcentrate 5.32Agriculturalpremises andequipmentPoultry Premises andEquipmentFloors, walls, and equipment,including incubators, hatchers,setters, trays, racks, carts, sexingtables, delivery trucks, troughs, rack,feeding and watering bins, bucketsand fountains. , incubators. Vehiclesincluding mats, crates, cabs andwheels.Spray, mop, wipe 1-2 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-476SolubleConcentrate 5.32Residential andpublic accesspremisesday care facilities, schools,hotels, motels, restaurantsHard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1-2 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-476SolubleConcentrate 5.32Residential andpublic accesspremisesDog and Cat Kennels Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1-2 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-476SolubleConcentrate 5.32Medical Premisesand EquipmentVeterinary hospitals, zoos,clinics, premises andequipmentInstrument trays, operating tables,and other hard, nonporous premisesand surfaces, including, walls andfloors.Spray, mop, wipe 1-2 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-476SolubleConcentrate 5.32Agriculturalpremises andequipmentCattle farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates cabs and wheels HaltersSpray, mop, wipe 1-2 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-476SolubleConcentrate 5.32Agriculturalpremises andequipmentSwine farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates cabs and wheels HaltersSpray, mop, wipe 1-2 oz. per gallon ofwater, wet surface. 10minute contact time.Medical Premisesand EquipmentMedical Institutions,premises and equipmentHard, inanimate, nonporous surfacessuch as walls, floors, door handles,medical bed surfaces, bed frames,mattress springs, wheelchairs, lightSpray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-680SolubleConcentrate 10.60switches, linen carts, stretcherwheels, hampers, telephones,cleanup carts, bassinets, dressing216400 464-680SolubleConcentrate 10.60Medical Premisesand EquipmentDental Premises andequipmentdental mixing spatulas, equipmenttrays, dental operating light fixturesand handles, instrument controlpanels, extra oral orthodonticheadgears, orthodontic plasticbrackets, and other non-critical, hard,nonporous, inanimate surfacesSpray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-680SolubleConcentrate 10.60Agriculturalpremises andequipmentPoultry Premises andEquipmentFloors, walls, and equipment,including incubators, hatchers,setters, trays, racks, carts, sexingtables, delivery trucks, troughs, rack,feeding and watering bins, bucketsand fountains. , incubators. Vehiclesincluding mats, crates, cabs andwheels.Spray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-680SolubleConcentrate 10.60Residential andpublic accesspremisesday care facilities, schools, ,hotels, motels, restaurantsHard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.32770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 464-680SolubleConcentrate 10.60Residential andpublic accesspremisesDog and Cat Kennels Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-680SolubleConcentrate 10.60Medical Premisesand EquipmentVeterinary hospitals,clinics, premises andequipmentInstrument trays, operating tables,and other hard, nonporous premisesand surfaces, including, walls andfloors.Spray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-680SolubleConcentrate 10.60Agriculturalpremises andequipmentCattle farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates cabs and wheels HaltersSpray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 464-680SolubleConcentrate 10.60Agriculturalpremises andequipmentSwine farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates cabs and wheels HaltersSpray, mop, wipe 1/2-1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 675-19SolubleConcentrate 2.70Medical Premisesand EquipmentMedical Institutions,premises and equipmentHard, inanimate, nonporous surfacessuch as walls, floors, door handles,medical bed surfaces, bed frames,mattress springs, wheelchairs, lightswitches, linen carts, stretcherwheels, hampers, telephones,cleanup carts, bassinets, dressingSpray, mop, wipe 1/4-4 oz. per gallon ofwater, wet surface. 10minute contact time.216400 675-19SolubleConcentrate 2.70Medical Premisesand EquipmentDental Premises andequipmentdental mixing spatulas, equipmenttrays, dental operating light fixturesand handles, instrument controlpanels, extra oral orthodonticheadgears, orthodontic plasticbrackets, and other non-critical, hard,nonporous, inanimate surfacesSpray, mop, wipe 1/4-4 oz. per gallon ofwater, wet surface. 10minute contact time.Medical Premisesand EquipmentMedical and DentalinstrumentsSurgical and dental instruments Immersion 1/4-4 oz. per gallon ofwater wet surface 15216400 675-19SolubleConcentrate 2.70andEquipmentinstrumentswater,wetsurface.15minute contact time.216400 675-19SolubleConcentrate 2.70Medical Premisesand EquipmentHuman waste Urine, feces Pour 4 oz per gallon ofwater. One hourcontact time.216400 675-19SolubleConcentrate 2.70Medical Premisesand EquipmentHospital Laundry Laundry, linens, blankets and diapers Pour 8 oz per 17 gallons ofwater and 10 poundsof laundry. Agitate forthree minutes , soakfor 10 minutes .Pre-wash treatment.216400 675-43SolubleConcentrate 5.11Medical Premisesand EquipmentMedical Institutions,premises and equipmentHard, inanimate, nonporous surfacessuch as walls, floors, door handles,medical bed surfaces, bed frames,mattress springs, wheelchairs, lightswitches, linen carts, stretcherwheels, hampers, telephones,cleanup carts, bassinets, dressingSpray, mop, wipe 4 tsp- 1 1/3 oz pergallon of water, wetsurface. 10 minutecontact time.42770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 675-43SolubleConcentrate 5.11Medical Premisesand EquipmentDental Premises andequipmentdental mixing spatulas, equipmenttrays, dental operating light fixturesand handles, instrument controlpanels, extra oral orthodonticheadgears, orthodontic plasticbrackets, and other non-critical, hard,nonporous, inanimate surfacesSpray, mop, wipe 4 tsp- 1 1/3 oz pergallon of water, wetsurface. 10 minutecontact time.216400 675-43SolubleConcentrate 5.11Medical Premisesand EquipmentMedical and DentalinstrumentsSurgical and dental instruments Immersion 4 tsp to 1-1/3 oz pergallon of water, wetsurface. 10 minutecontact time.216400 777-94SolubleConcentrate 5.50Residential andpublic accesspremisesHousehold/domesticdwellings indoor premisesHard, inanimate, nonporous surfacessuch as Appliance Exteriors,Bathroom Surfaces, Bathtubs (Tub),Changing Tables (non-wood),Countertops, Cribs (non-wood),Diaper Pails (non-wood), Door Knobs(Handle), Enamel tile, Faucets,Spray, mop, wipe 1-1/4 oz. per gallon ofwater, wet surface. 10minute contact time.Rinse all food contact areas with potable water.216400 777-94SolubleConcentrate 5.50Residential andpublic accesspremisesHousehold/domesticdwellings indoor premisesToilet Bowl interiors pour 1/2 oz into toilet bowlwater. 10 Minutecontact time.216400 777-94SolubleConcentrate 5.50Medical Premisesand EquipmentHospital Laundry Laundry, linens, blankets and diapers Pour 8 oz per washload Pre-wash treatment.Medical Premisesand EquipmentMedical Institutions,premises and equipmentHard, inanimate, nonporous surfacessuch as walls, floors, door handles,medical bed surfaces, bed frames,mattress springs, wheelchairs, lightit h li t t t hSpray, mop, wipe 1-1/4 oz. per gallon ofwater, wet surface. 10minute contact time.216400 777-94SolubleConcentrate 5.50switches,linen carts, stretcherwheels, hampers, telephones,cleanup carts, bassinets, dressing216400 954-13SolubleConcentrate 4.75Medical Premisesand EquipmentMedical Institutions,premises and equipmentHard, inanimate, nonporous surfacessuch as walls, floors, door handles,medical bed surfaces, bed frames,mattress springs, wheelchairs, lightswitches, linen carts, stretcherwheels, hampers, telephones,cleanup carts, bassinets, dressingSpray, mop, wipe 1 oz. per 32 oz. ofwater, wet surface. 10minute contact time.Allow to air dry.216400 954-13SolubleConcentrate 4.75Medical Premisesand EquipmentHair Salons Nippers, brushes, combs, rollers,tweezers, razors, clipper blades,manicure, pedicure, and otherimplements commonly found insalons, including most plastics.Immersion 1 oz. per 32 oz. ofwater, wet surface. 10minute contact time.Allow to air dry.216400 954-13SolubleConcentrate 4.75Medical Premisesand EquipmentMedical and DentalinstrumentsSurgical and dental instruments Immersion 1 oz. per 32 oz. ofwater, wet surface. 10minute contact time.Allow to air dry.52770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 1043-19Ready to usespray 0.077Residential andpublic accesspremisesAir Treatments Schools, medical, dental andbusiness offices, homes, sick rooms,nursing homes and general hospitalareas.Spray Spray upward tocenter of room for 3-5seconds.216400 1043-19Ready to usespray 0.077Residential andpublic accesspremisesDay care facilities, schools,hotels, motels and businessofficesHard non porous areas, including,walls, floors and premisesSpray Hold 6-9 inches fromsurface and sprayuntil wet, 2-3seconds. 10 minutescontact time Allow to216400 1043-19Ready to usespray 0.077Medical Premisesand EquipmentMedical Institutions,premises and equipmentHard, inanimate, nonporous surfacessuch as walls, floors, door handles,medical bed surfaces, bed frames,mattress springs, wheelchairs, lightswitches linen carts stretcherSpray Hold 6-9 inches fromsurface and sprayuntil wet, 2-3seconds. 10 minutescontact time Allow to216400 1043-26SolubleConcentrate 8.5Agriculturalpremises andequipmentCattle farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates cabs and wheels HaltersSpray, mop, wipe 1/2 oz. per gallon ofwater, wet surface. 10minute contact time.216400 1043-26SolubleConcentrate 8.5Agriculturalpremises andequipmentSwine farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates cabs and wheels HaltersSpray, mop, wipe 1/2 oz. per gallon ofwater, wet surface. 10minute contact time.216400 1043-26SolubleConcentrate 8.5Agriculturalpremises andequipmentPoultry Premises andEquipmentFloors, walls, and equipment,including incubators, hatchers,setters, trays, racks, carts, sexingtables, delivery trucks, troughs, rack,feeding and watering bins, bucketsand fountains. , incubators. Vehiclesincluding mats, crates, cabs andwheels.Spray, mop, wipe 1/2 oz. per gallon ofwater, wet surface. 10minute contact time.2164001043 26SolubleConcentrate8 5Agriculturalpremises andequipmentMushroom Houses Tools, equipment, breezeways, trackalleys before spawning, inside andoutside walls of mushroom houses,lofts, floors, storage sheds, spawningSpray, mop, wipe 1/2 oz. per gallon ofwater, wet surface. 10minute contact time.2164001043-26Concentrate8.5g pgmachines tampers and casing rings216400 1043-26SolubleConcentrate 8.5Agriculturalpremises andequipmentAgricultural premises Food contact surfaces, tools, andequipmentSpray, mop, wipe 1/2 oz. per gallon ofwater, wet surface. 10minute contact time.Rinse all food contact areas with potable water.216400 1043-26SolubleConcentrate 8.5Agriculturalpremises andequipmentPoultry Premises andEquipmentHatchery rooms Fog 1/2 gallon per gallonof water. Use 32-64oz of preparedsolution per 1000 cuftPreclean premises and close off area to be treated.Do not allow people to contact or breathe fog. Donot enter until product has settled. Ventilate areasthoroughly.216400 303-223SolubleConcentrate 5.32Medical Premisesand EquipmentVeterinary hospitals, zoos,clinics, premises andequipmentInstrument trays, operating tables,and other hard, nonporous premisesand surfaces, including, walls andfloors.Fog 1/2 gallon per gallonof water. Use 32-64oz of preparedsolution per 1000 cuftPreclean premises and close off area to be treated.Do not allow people to contact or breathe fog. Donot enter until product has settled. Ventilate areasthoroughly.216400 1043-26SolubleConcentrate 8.5Agriculturalpremises andequipmentFarm premises andequipmentHard non porous areas, including,walls, floors and premisesFog 1/2 gallon per gallonof water. Use 32-64oz of preparedsolution per 1000 cuftPreclean premises and close off area to be treated.Do not allow people to contact or breathe fog. Donot enter until product has settled. Ventilate areasthoroughly.216400 1043-118SolubleConcentrate 6.4Commercial,institutional andindustrial premisesCommercial and institutionalfloors and premisesHard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.62770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 1043-118SolubleConcentrate 6.4Medical Premisesand EquipmentVeterinary hospitals,clinics, premises andequipmentInstrument trays, operating tables,and other hard, nonporous premisesand surfaces, including, walls andfloors.Spray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 1043-118SolubleConcentrate 6.4Residential andpublic accesspremisesDay care facilities, schools,hotels, motels and businessofficesHard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 1677-128SolubleConcentrate 1.4Food handlingprocessingequipment andpremisesBeverage, food and dairyprocessing equipmentConveyor belts Metered spray 1 1/4 oz per gallon ofwater (1% by volume)5 minute contact time216400 2212-17SolubleConcentrate 3.8Medical Premisesand EquipmentUltrasonic cleaners Non-porous instruments or appliances Immersion Prepare a solution of1 oz per gallon ofwater. Addrecommendedamount to cleaner.10 minute run cycle.216400 2212-17SolubleConcentrate 3.8Medical Premisesand EquipmentHospital semi-critical items Precleaning of Non-porousinstruments or appliances prior toterminal sterilizationImmersion 1 oz per gallon ofwater, 10 minutescontact time.Thoroughly rinseitems beforesterilization.216400 2212-17SolubleConcentrate 3.8Commercial,institutional andindustrial premisesand equipmentwalls, floors and otherinanimate hard, nonporoussurfaceswalls, floors, furniture, shower/bathingareas, lavatories and other hard nonporous inanimate surfacesSpray, mop, wipe 1 oz per gallon ofwater, 10 minutescontact time.SolubleMedical Premisesand EquipmentHospital and medicalinstitutions non-criticalpremises and equipment`walls, floors, furniture, shower/bathingareas, lavatories and other hard nonporous inanimate surfacesSpray, mop, wipe 1 oz per gallon ofwater, 10 minutescontact time.216400 2212-17SolubleConcentrate 3.8216400 2296-102SolubleConcentrate 3.6Medical Premisesand EquipmentHospital and medicalinstitutions non-criticalpremises and equipment`walls, floors, furniture, shower/bathingareas, lavatories and other hard nonporous inanimate surfacesSpray, mop, wipe 3.5 Tbs per gallon ofwater, 10 minutecontact time.216400 2296-102SolubleConcentrate 3.6Residential andpublic accesspremisesToilet Bowls Hard, nonporous toilet bowl interiors Spray, wipe 3.5 Tbs per gallon ofwater, 10 minutecontact time.216400 2296-102SolubleConcentrate 3.6Residential andpublic accesspremisesGarbage receptacles Garbage pails and receptacles Spray 4 Tbs per gallon ofwater. Rinse emptycan with solution.216400 2296-102SolubleConcentrate 3.6Agriculturalpremises andequipmentFarm premises andequipmentHard non porous areas, including,walls, floors and premisesSpray, mop, wipe 3.5 Tbs per gallon ofwater, 10 minutecontact time.72770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 2296-102SolubleConcentrate 3.6Agriculturalpremises andequipmentPoultry Premises andEquipmentFloors, walls, and equipment,including incubators, hatchers,setters, trays, racks, carts, sexingtables, delivery trucks, troughs, rack,feeding and watering bins, bucketsand fountains. , incubators. Vehiclesincluding mats, crates, cabs andwheels.Spray, mop, wipe 3.5 Tbs per gallon ofwater, 10 minutecontact time.216400 2296-105SolubleConcentrate 2.0Residential andpublic accesspremisesHotels, apartment buildings,households, motels,schools and office buildingsToilets, urinals, lavatories, showerstalls, floors, walls,Spray, mop, wipe 2-8 oz. per gallon ofwater, 10 minutecontact time.216400 2296-105SolubleConcentrate 2.0Commercial ,institutional, andindustrial premisesIndustrial plants Toilets, urinals, lavatories, showerstalls, floors, walls,Spray, mop, wipe 2 oz. per gallon ofwater, 10 minutecontact time.216400 2296-105SolubleConcentrate 2.0Residential andpublic accesspremisesToilet Bowls Hard, nonporous toilet bowl interiors Spray, wipe 2 oz. per gallon ofwater, 10 minutecontact time.216400 3862-177SolubleConcentrate 10.0Medical Premisesand EquipmentHospital and medicalinstitutions non-criticalpremises and equipment`walls, floors, furniture, shower/bathingareas, lavatories and other hard nonporous inanimate surfacesSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.Agriculturalpremises andequipmentPoultry Premises andEquipmentFloors, walls, and equipment,including incubators, hatchers,setters, trays, racks, carts, sexingt bl d li t k t h kSpray, mop, wipe, fog 1/2 oz. per gallon ofwater, 10 minutecontact time.For fog applications allow 10 minutes to two hoursventilation before reentry216400 3862-177SolubleConcentrate 10.0tables,deliverytrucks,troughs, rack,feeding and watering bins, bucketsand fountains. , incubators. Vehiclesincluding mats, crates, cabs andwheels.216400 3862-177SolubleConcentrate 10.0Agriculturalpremises andequipmentCattle farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates, cabs and wheels. Halters,ropes, and other types of equipmentused in handling and restraininganimalsSpray, mop, wipe, fog 1/2 oz. per gallon ofwater, 10 minutecontact time.Do not use in milking stalls or areas. For fogapplications allow 10 minutes to two hoursventilation before reentry216400 3862-177SolubleConcentrate 10.0Agriculturalpremises andequipmentSwine farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates, cabs and wheels. Halters,ropes, and other types of equipmentused in handling and restraininganimalsSpray, mop, wipe, fog 1/2 oz. per gallon ofwater, 10 minutecontact time.Do not use in milking stalls or areas. For fogapplications allow 10 minutes to two hoursventilation before reentry216400 3862-177SolubleConcentrate 10.0Agriculturalpremises andequipmentHorse Stables Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe, fog 1/2 oz. per gallon ofwater, 10 minutecontact time.For fog applications allow 10 minutes to two hoursventilation before reentry82770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 3862-177SolubleConcentrate 10.0Agriculturalpremises andequipmentPoultry Premises andEquipmentHatchery rooms, hatching eggsanitizer.Automatic washingsystems, immersiontanks, foamingapparatus, LPsprayers and fogging1/2 oz. per gallon ofwater.216400 3862-177SolubleConcentrate 10.0Agriculturalpremises andequipmentPoultry Premises andEquipmentBird cages Spray, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 3862-178SolubleConcentrate 6.5Medical Premisesand EquipmentHospital and medicalinstitutions non-criticalpremises and equipment`walls, floors, furniture, shower/bathingareas, lavatories and other hard nonporous inanimate surfacesSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 3862-178SolubleConcentrate 6.5Agriculturalpremises andequipmentPoultry Premises andEquipmentFloors, walls, and equipment,including incubators, hatchers,setters, trays, racks, carts, sexingtables, delivery trucks, troughs, rack,feeding and watering bins bucketsSpray, mop, wipe, fog 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 3862-178SolubleConcentrate 6.5Agriculturalpremises andequipmentFarm premises andequipmentHard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 3862-179SolubleConcentrate 3.0Medical Premisesand EquipmentHospital and medicalinstitutions non-criticalpremises and equipment`walls, floors, furniture, shower/bathingareas, lavatories and other hard nonporous inanimate surfacesSpray, mop, wipe, fog 1 oz. per gallon ofwater, 10 minutecontact time.216400 3862-179SolubleConcentrate 3.0Agriculturalpremises andequipmentPoultry Premises andEquipmentFloors, walls, and equipment,including incubators, hatchers,setters, trays, racks, carts, sexingtables, delivery trucks, troughs, rack,feeding and watering bins, bucketsand fountains incubators VehiclesSpray, mop, wipe, fog 1 oz. per gallon ofwater, 10 minutecontact time. For foguses, add solution toapproved timedfogger 6 min perFor fog applications allow two hours ventilationbefore reentryand fountains incubators Vehicles216400 3862-179SolubleConcentrate 3.0Agriculturalpremises andequipmentFarm premises andequipmentHard non porous areas, including,walls, floors and premisesSpray, mop, wipe, fog 1 oz. per gallon ofwater, 10 minutecontact time. For foguses, add solution toapproved timedfogger,6 minperFor fog applications allow two hours ventilationbefore reentry216400 3862-180SolubleConcentrate 5.06Residential andpublic accesspremisesHotels, apartment buildings,households, motels,schools and office buildingswalls, floors, furniture, shower/bathingfixtures, drinking fountains, sinks,refrigerators, stoves, and other hardnon-porous inanimate surfacesSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 3862-180SolubleConcentrate 5.06Commercial ,institutional, andindustrial premisesIndustrial plants walls, floors, furniture, shower/bathingfixtures, drinking fountains, sinks,refrigerators, stoves, and other hardnon-porous inanimate surfacesSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 3862-180SolubleConcentrate 5.06Residential andpublic accesspremisesGarbage receptacles Garbage pails and receptacles Spray 1/2 oz. per gallon ofwater, 10 minutecontact time.92770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 3862-180SolubleConcentrate 5.06Agriculturalpremises andequipmentSwine farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates, cabs and wheels. Halters,ropes, and other types of equipmentused in handling and restrainingSpray, mop, wipe, fog 1/2 oz. per gallon ofwater, 10 minutecontact time. For foguses, add solution toapproved timedfogger, 3 min per2000 cu. Ft.For fog applications allow two hours ventilationbefore reentry216400 3862-180SolubleConcentrate 5.06Agriculturalpremises andequipmentPoultry Premises andEquipmentFloors, walls, and equipment,including incubators, hatchers,setters, trays, racks, carts, sexingtables, delivery trucks, troughs, rack,feeding and watering bins, bucketsand fountains. , incubators. Vehiclesincluding mats, crates, cabs andwheelsSpray, mop, wipe, fog 1/2 oz. per gallon ofwater, 10 minutecontact time. For foguses, add solution toapproved timedfogger, 3 min per2000 cu. Ft.For fog applications allow two hours ventilationbefore reentry216400 3862-180SolubleConcentrate 5.06Agriculturalpremises andequipmentFarm premises andequipmentHard non porous areas, including,walls, floors and premisesSpray, mop, wipe, fog 1/2 oz. per gallon ofwater, 10 minutecontact time. For foguses, add solution toapproved timedfogger, 3 min per2000 cu. Ft.For fog applications allow two hours ventilationbefore reentry216400 3862-180SolubleConcentrate 5.06Medical Premisesand EquipmentBarber/beauty shopinstruments.Combs, brushes, razors, scissors Wipe, immersion 1/2 oz. per gallon ofwater, 10 minutecontact time.PressurizedResidential andpublic accesspremisesHotels, apartment buildings,households, motels,schools and office buildingswalls, floors, furniture, shower/bathingfixtures, drinking fountains, sinks,refrigerators, stoves, and other hardnon-porous inanimate surfacesSpray Hold 6-8 inches fromsurface and sprayuntil wet, 2-3seconds. 10 minutescontact time. Allow toair dry216400 5741-22PressurizedLiquid 0.071airdry.216400 5741-22PressurizedLiquid 0.071Commercial ,institutional, andindustrial premisesIndustrial plants walls, floors, furniture, shower/bathingfixtures, drinking fountains, sinks,refrigerators, stoves, and other hardnon-porous inanimate surfacesSpray Hold 6-8 inches fromsurface and sprayuntil wet, 2-3seconds. 10 minutescontact time. Allow toair dry.216400 6836-252SolubleConcentrate 9.5Medical Premisesand EquipmentMedical Institutions,premises and equipmentUse on hard, nonporous surfacessuch as floors, walls, metal surfaces,painted surfaces, exterior bowlsurfaces, empty basins, showers,conductive flooring and lavatoryfixtures.Spray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 6836-252SolubleConcentrate 9.5Medical Premisesand EquipmentDental Premises andequipmentUse on hard, nonporous surfacessuch as floors, walls, metal surfaces,painted surfaces, exterior bowlsurfaces, empty basins, showers,conductive flooring and lavatoryfixtures.Spray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.102770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 6836-252SolubleConcentrate 9.5Agriculturalpremises andequipmentPoultry Premises andEquipmentFloors, walls, and equipment,including incubators, hatchers,setters, trays, racks, carts, sexingtables, delivery trucks, troughs, rack,feeding and watering bins, bucketsand fountains. , incubators. Vehiclesincluding mats, crates, cabs andwheels.Spray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 6836-252SolubleConcentrate 9.5Agriculturalpremises andequipmentPoultry Premises andEquipmentHatchery rooms, Incubators andhatchersSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 6836-252SolubleConcentrate 9.5Food handlingprocessingequipment andpremisesMeat and poultryprocessing plantsHard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.Food products and packaging materials must beremoved from the room or carefully protected. Useproduct in accordance with its label. All surfacesmust be thoroughly rinsed with potable water.216400 6836-252SolubleConcentrate 9.5Agriculturalpremises andequipmentShoe Baths Entrances to buildings and livestockhousing areas.Spray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 6836-252SolubleConcentrate 9.5Residential andpublic accesspremisesDay care facilities, schools,hotels, motels, restaurantsHard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 6836-252SolubleConcentrate 9.5Residential andpublic accesspremisesDog and Cat Kennels Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 6836-252SolubleConcentrate 9.5Medical Premisesand EquipmentVeterinary hospitals,clinics, premises andequipmentInstrument trays, operating tables,and other hard, nonporous premisesand surfaces, including, walls andfloors.Spray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.Agriculturalpremises andequipmentCattle farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates,cabs and wheels. Halters,Spray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 6836-252SolubleConcentrate 9.5, ,ropes, and other types of equipmentused in handling and restraininganimals216400 6836-252SolubleConcentrate 9.5Agriculturalpremises andequipmentSwine farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates, cabs and wheels. Halters,ropes, and other types of equipmentused in handling and restraininganimalsSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 6836-252SolubleConcentrate 9.5Agriculturalpremises andequipmentHorse Stables Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 6836-253SolubleConcentrate 4.75Medical Premisesand EquipmentMedical Institutions,premises and equipmentUse on hard, nonporous surfacessuch as floors, walls, metal surfaces,painted surfaces, exterior bowlsurfaces, empty basins, showers,conductive flooring and lavatoryfixtures.Spray, mop, wipe 1 oz. per gallon ofwater, 10 minutecontact time.112770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 6836-253SolubleConcentrate 4.75Medical Premisesand EquipmentDental Premises andequipmentUse on hard, nonporous surfacessuch as floors, walls, metal surfaces,painted surfaces, exterior bowlsurfaces, empty basins, showers,conductive flooring and lavatoryfixtures.Spray, mop, wipe 1 oz. per gallon ofwater, 10 minutecontact time.216400 6836-253SolubleConcentrate 4.75Agriculturalpremises andequipmentPoultry Premises andEquipmentFloors, walls, and equipment,including incubators, hatchers,setters, trays, racks, carts, sexingtables, delivery trucks, troughs, rack,feeding and watering bins, bucketsand fountains. , incubators. Vehiclesincluding mats, crates, cabs andwheels.Spray, mop, wipe 1 oz. per gallon ofwater, 10 minutecontact time.216400 6836-253SolubleConcentrate 4.75Food handlingprocessingequipment andpremisesMeat and poultryprocessing plantsHard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1 oz. per gallon ofwater, 10 minutecontact time.Food products and packaging materials must beremoved from the room or carefully protected. Useproduct in accordance with its label. All surfacesmust be thoroughly rinsed with potable water.216400 6836-253SolubleConcentrate 4.75Residential andpublic accesspremisesToilet Bowls Hard, nonporous toilet bowl interiors Spray, wipe 1 oz. per gallon ofwater, 10 minutecontact time.216400 6836-253SolubleConcentrate 4.75Agriculturalpremises andequipmentPoultry Premises andEquipmentHatchery rooms, Incubators andhatchersSpray, mop, wipe 1 oz. per gallon ofwater, 10 minutecontact time.216400 6836-253SolubleConcentrate 4.75Agriculturalpremises andequipmentShoe Baths Entrances to buildings and livestockhousing areas.Spray, mop, wipe 1 oz. per gallon ofwater, 10 minutecontact time.216400 6836-253SolubleConcentrate 4.75Residential andpublic accesspremisesDay care facilities, schools,hotels, motels, restaurantsHard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1 oz. per gallon ofwater, 10 minutecontact time.Residential and Dog and Cat Kennels Hard non porous areas, including, Spray, mop, wipe 1 oz. per gallon of216400 6836-253SolubleConcentrate 4.75public accesspremiseswalls, floors and premises water, 10 minutecontact time.216400 6836-253SolubleConcentrate 4.75Medical Premisesand EquipmentVeterinary hospitals,clinics, pet shops, premisesand equipmentInstrument trays, operating tables,and other hard, nonporous premisesand surfaces, including, walls andfloors.Spray, mop, wipe 1 oz. per gallon ofwater, 10 minutecontact time.216400 6836-253SolubleConcentrate 4.75Agriculturalpremises andequipmentCattle farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates, cabs and wheels. Halters,ropes, and other types of equipmentused in handling and restraininganimalsSpray, mop, wipe 1 oz. per gallon ofwater, 10 minutecontact time.216400 6836-253SolubleConcentrate 4.75Agriculturalpremises andequipmentSwine farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates, cabs and wheels. Halters,ropes, and other types of equipmentused in handling and restraininganimalsSpray, mop, wipe 1 oz. per gallon ofwater, 10 minutecontact time.122770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 6836-253SolubleConcentrate 4.75Agriculturalpremises andequipmentHorse Stables Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1 oz. per gallon ofwater, 10 minutecontact time.216400 33176-6PressurizedLiquid 0.08Medical Premisesand EquipmentHospital semi-critical items Precleaning of Non-porousinstruments or appliances prior toterminal sterilizationSpray Spray until surface iswet, allow to air dry/10minute contact time.216400 33176-6PressurizedLiquid 0.08Residential andpublic accesspremisesHotels, apartment buildings,households, motels,schools and office buildingswalls, woodwork, cabinets, floors,files, wash basins, bathtubs, toiletseats, venetian blinds, chrome andstainless steel, stoves, canopies,exterior of refrigerators and freezers,sinks, appliances, porcelain, ceramic,counter and table tops.Spray Spray until surface iswet, allow to air dry/10minute contact time.216400 33176-6PressurizedLiquid 0.08Medical Premisesand EquipmentHospital and medicalinstitutions non-criticalpremises and equipment`walls, woodwork, cabinets, floors,files, wash basins, bathtubs, toiletseats, venetian blinds, chrome andstainless steel, stoves, canopies,exterior of refrigerators and freezers,sinks, appliances, porcelain, ceramic,counter and table tops.Spray Spray until surface iswet, allow to air dry/10minute contact time.216400 34810-8SolubleConcentrate 5.76Residential andpublic accesspremisesSchools and office buildings Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.Medical Premisesand EquipmentHospital and medicalinstitutions non criticalHard non porous areas, including,walls floors and premisesSpray, mop, wipe 1/2 oz. per gallon ofwater 10 minute216400 34810-8SolubleConcentrate 5.76andEquipmentinstitutions non-criticalpremises and equipment`walls,floors andpremises water,10minutecontact time.216400 34810-8SolubleConcentrate 5.76Food handlingprocessingequipment andpremisesMeat and poultryprocessing plantsHard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.Food products and packaging materials must beremoved from the room or carefully protected. Useproduct in accordance with its label. All surfacesmust be thoroughly rinsed with potable water.216400 34810-21Ready to usesolution 0.023Residential andpublic accesspremisesAthletic Facilities, PolicefacilitiesHard, nonporous inanimate surfaces:floors, walls, metal surfaces, stainlesssteel surfaces, glazed porcelain,plastic surfaces.Spray, mop, wipe Wet surfacesthoroughly, 10 minutecontact time216400 34810-21Ready to usesolution 0.023Medical Premisesand EquipmentOperating Rooms, IntensiveCare, Nurseries,Emergency Areas, DentalOperatories.Hard, nonporous inanimate surfaces:floors, walls, metal surfaces, stainlesssteel surfaces, glazed porcelain,plastic surfaces.Spray, mop, wipe Wet surfacesthoroughly, 10 minutecontact time132770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 34810-21Ready to usesolution 0.023Medical Premisesand EquipmentHospital semi-critical items Precleaning of Non-porousinstruments or appliances prior toterminal sterilizationImmersion Wet surfacesthoroughly, 10 minutecontact time216400 34810-31SolubleConcentrate 3.03Medical Premisesand EquipmentMedical Institutions,premises and equipmentHard non porous areas, including,walls, bathroom fixtures, stainlesssteel, chrome, glass and vinyl.Spray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 34810-31SolubleConcentrate 3.03Medical Premisesand EquipmentDental Premises andequipmentHard non porous areas, including,walls, bathroom fixtures, stainlesssteel, chrome, glass and vinyl.Spray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 34810-31SolubleConcentrate 3.03Medical Premisesand EquipmentWhirlpool baths and footspasHard non porous surfaces in whirlpoolbath and foot spa unitscirculation, mop, wipe 1 oz. per gallon ofwater. Drain unit andfill with preparedsolution, run pump for10 minutes. Drain,rinse and allow to airdry.216400 34810-31SolubleConcentrate 3.03Medical Premisesand EquipmentHair Salons Nippers, brushes, combs, rollers,tweezers, razors, clipper blades,manicure, pedicure, and otherimplements commonly found insalons, including most plastics.Immersion 1 oz. per gallon ofwater, wet surface. 10minute contact time.21640034810 31SolubleConcentrate3 03Agriculturalpremises andequipmentFarm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates, cabs and wheels. Halters,ropes and other types of equipmentSpray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.21640034810-31Concentrate3.03ropes,andothertypesofequipment216400 34810-31SolubleConcentrate 3.03Agriculturalpremises andequipmentPoultry Premises andEquipmentFloors, walls, and equipment,including incubators, hatchers,setters, trays, racks, carts, sexingtables, delivery trucks, troughs, rack,feeding and watering bins, bucketsand fountains. , incubators. Vehiclesincluding mats, crates, cabs andwheels.Spray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 34810-31SolubleConcentrate 3.03Residential andpublic accesspremisesday care facilities, schools,hotels, motels, restaurants,Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 34810-31SolubleConcentrate 3.03Medical Premisesand EquipmentVeterinary hospitals,clinics, premises andequipmentInstrument trays, operating tables,and other hard, nonporous premisesand surfaces, including, walls andfloors.Spray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 39967-5TechnicalChemical 98.6For manufacturing use only142770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 39967-6FormulationIntermediate 75.0For manufacturing use only216400 39967-81SolubleConcentrate 5.0Commercial ,institutional, andindustrial premisesCommercial transportationfacilitiesTransportation equipment Spray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 39967-81SolubleConcentrate 5.0Residential andpublic accesspremisesAnimal kennels Animal cages and holding areas Spray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 39967-81SolubleConcentrate 5.0Medical Premisesand EquipmentVeterinary hospitals,clinics, premises andequipmentHard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 39967-81SolubleConcentrate 5.0Medical Premisesand EquipmentMedical Institutions,premises and equipmentwalls, woodwork, cabinets, floors,files, wash basins, bathtubs, toiletseats, venetian blinds, chrome andstainless steel, stoves, canopies,exterior of refrigerators and freezers,sinks, appliances, porcelain, ceramic,counter and table topsSpray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 39967-81SolubleConcentrate 5.0Agriculturalpremises andequipmentFarm premises andequipmentHard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 39967-81SolubleConcentrate 5.0Medical Premisesand EquipmentHospital and medicalinstitutions non-criticalpremises and equipment`Conductive flooring in operatingrooms.Spray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.Medical PremisesMedical Institutions,walls,woodwork,cabinets,floors,Spray,mop,wipe1/2oz.pergallonof216400 39967-83SolubleConcentrate 10.0MedicalPremisesand EquipmentMedicalInstitutions,premises and equipmentwalls,woodwork,cabinets,floors,files, wash basins, bathtubs, toiletseats, venetian blinds, chrome andstainless steel, stoves, canopies,exterior of refrigerators and freezers,sinks, appliances, porcelain, ceramic,Spray,mop,wipe1/2oz.pergallonofwater, 10 minutecontact time.216400 39967-83SolubleConcentrate 10.0Medical Premisesand EquipmentHospital semi-critical items Precleaning of Non-porousinstruments or appliances prior toterminal sterilizationSpray, immersion 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 39967-83SolubleConcentrate 10.0Agriculturalpremises andequipmentFarm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates, cabs and wheels. Halters,ropes, and other types of equipmentused in handling and restraininganimalsSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.152770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 39967-83SolubleConcentrate 10.0Agriculturalpremises andequipmentPoultry Premises andEquipmentFloors, walls, and equipment,including incubators, hatchers,setters, trays, racks, carts, sexingtables, delivery trucks, troughs, rack,feeding and watering bins, bucketsand fountains. , incubators. Vehiclesincluding mats, crates, cabs andwheels.Spray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 46851-1SolubleConcentrate 1.0Medical Premisesand EquipmentHospital semi-critical items Precleaning of Non-porousinstruments or appliances prior toterminal sterilizationSpray, immersion Add 4 oz to 124 oz ofwater, 10 minutecontact time216400 46851-1SolubleConcentrate 1.0Medical Premisesand EquipmentUltrasonic cleaners Non-porous instruments or appliances Immersion add 4 oz to 124 oz ofwater. Addrecommendedamount of made upsolution to device216400 46851-1SolubleConcentrate 1.0Medical Premisesand EquipmentMedical Institutions,premises and equipmentUse on hard, nonporous surfacessuch as floors, walls, metal surfaces,painted surfaces, exterior bowlsurfaces, empty basins, showers,and lavatory fixturesSpray, mop, wipe Add 4 oz to 124 oz ofwater, 10 minutecontact time216400 46851-1SolubleConcentrate 1.0Medical Premisesand EquipmentVeterinary hospitals,clinics, premises andequipmentUse on hard, nonporous surfacessuch as floors, walls, metal surfaces,painted surfaces, exterior bowlsurfaces, empty basins, showers,and lavatory fixturesSpray, mop, wipe Add 4 oz to 124 oz ofwater, 10 minutecontact time216400 46851-1SolubleConcentrate 1.0Medical Premisesand EquipmentDental Premises andequipmentUse on hard, nonporous surfacessuch as floors, walls, metal surfaces,painted surfaces, exterior bowlsurfaces, empty basins, showers,and lavatory fixtures.Spray, mop, wipe Add 4 oz to 124 oz ofwater, 10 minutecontact timeMedical PremisesMedical InstitutionsHard non porous areas includingSpray mop wipeThoroughly wet216400 46851-5Ready to usesolution 0.03MedicalPremisesand EquipmentMedicalInstitutions,premises and equipmentHardnonporousareas,including,walls, floors and premisesSpray,mop,wipeThoroughlywetsurface, 10 minutecontact time.216400 46851-5Ready to usesolution 0.03Medical Premisesand EquipmentVeterinary hospitals,clinics, premises andequipmentHard non porous areas, including,walls, floors and premisesSpray, mop, wipe Thoroughly wetsurface, 10 minutecontact time.216400 46851-5Ready to usesolution 0.03Medical Premisesand EquipmentDental Premises andequipmentUse on hard, nonporous surfacessuch as floors, walls, metal surfaces,painted surfaces, exterior bowlsurfaces, empty basins, showers,and lavatory fixturesSpray, mop, wipe Thoroughly wetsurface, 10 minutecontact time.216400 46851-10ImpregnatedMaterials 0.03Medical Premisesand EquipmentMedical Institutions,premises and equipmentUse on hard, nonporous surfacessuch as floors, walls, metal surfaces,painted surfaces, exterior bowlsurfaces, empty basins, showers,and lavatory fixturesWipe Thoroughly wetsurface, 10 minutecontact time.216400 46851-10ImpregnatedMaterials 0.03Medical Premisesand EquipmentVeterinary hospitals,clinics, premises andequipmentUse on hard, nonporous surfacessuch as floors, walls, metal surfaces,painted surfaces, exterior bowlsurfaces, empty basins, showers,and lavatory fixturesWipe Thoroughly wetsurface, 10 minutecontact time.162770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 46851-10ImpregnatedMaterials 0.03Medical Premisesand EquipmentDental Premises andequipmentUse on hard, nonporous surfacessuch as floors, walls, metal surfaces,painted surfaces, exterior bowlsurfaces, empty basins, showers,and lavatory fixturesWipe Thoroughly wetsurface, 10 minutecontact time.216400 46851-10ImpregnatedMaterials 0.03Commercial ,institutional, andindustrial premisesCommercial transportationvehiclesAmbulances, boats, autos, policevehiclesWipe Thoroughly wetsurface, 10 minutecontact time.216400 46851-10ImpregnatedMaterials 0.03Residential andpublic accesspremisesBathrooms Hard non porous areas, including,walls, floors and premisesWipe Thoroughly wetsurface, 10 minutecontact time.216400 46851-10ImpregnatedMaterials 0.03Residential andpublic accesspremisesHousehold and domesticdwellingsHard non porous areas, including,walls, floors and premisesWipe Thoroughly wetsurface, 10 minutecontact time.216400 46851-10ImpregnatedMaterials 0.03Residential andpublic accesspremisesSchools, grocery stores,shopping centers, hotelsHard non porous areas, including,walls, floors and premisesWipe Thoroughly wetsurface, 10 minutecontact time.216400 61282-53SolubleConcentrate 9.97Medical Premisesand EquipmentMedical Institutions,premises and equipmentHard, inanimate, nonporous surfacessuch as walls, floors, door handles,medical bed surfaces, bed frames,mattress springs, wheelchairs, lightswitches, linen carts, stretcherwheels, hampers, telephones,cleanup carts, bassinets, dressingSpray, mop, wipe 1/2-1 1/2 oz. pergallon of water, wetsurface. 10 minutecontact time.Agriculturalpremises andequipmentPoultry Premises andEquipmentFloors, walls, and equipment,including incubators, hatchers,setters, trays, racks, carts, sexingtables, delivery trucks, troughs, rack,Spray, mop, wipe 1/2-1 1/2 oz. pergallon of water, wetsurface. 10 minutecontact time.216400 61282-53SolubleConcentrate 9.97feeding and watering bins, bucketsand fountains. , incubators. Vehiclesincluding mats, crates, cabs andwheels.216400 61282-53SolubleConcentrate 9.97Agriculturalpremises andequipmentPoultry Premises andEquipmentHatchery rooms Fog 1/2 gallon to 2.5gallons water inapproved foggerappliance. Oneminute per 4 000 cuPreclean premises and close off area to be treated.Do not allow people to contact or breathe fog. Donot enter until product has settled. Ventilate areasthoroughly.216400 61282-53SolubleConcentrate 9.97Agriculturalpremises andequipmentPoultry Premises andEquipmentIncubators and hatchers Fog 6 oz per 122 oz ofwater, fog 3-8 oz intosetters and hatchers.Repeat daily in settersand every 12 hours inhatchers. Do not usefor at least 24 hours1/2 oz per gallon of water of water maybe usedhourly or every other hour. Fog for 30-90 seconds.Do not allow people to contact or breathe fog. Donot enter until product has settled (30-60 minutes ).Ventilate areas thoroughly.216400 61282-53SolubleConcentrate 9.97Agriculturalpremises andequipmentShoe Baths Entrances to buildings and livestockhousing areas.Spray, mop, wipe 1/2-1 1/2 oz. pergallon of water, wetsurface. 10 minutecontact time.172770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 61282-53SolubleConcentrate 9.97Residential andpublic accesspremisesday care facilities, schools,hotels, motels, restaurants,Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2-1 1/2 oz. pergallon of water, wetsurface. 10 minutecontact time.216400 61282-53SolubleConcentrate 9.97Medical Premisesand EquipmentVeterinary hospitals,clinics, premises andequipmentInstrument trays, operating tables,and other hard, nonporous premisesand surfaces, including, walls andfloors.Spray, mop, wipe 1/2-1 1/2 oz. pergallon of water, wetsurface. 10 minutecontact time.216400 61282-53SolubleConcentrate 9.97Agriculturalpremises andequipmentCattle farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates, cabs and wheels. Halters,ropes and other types of equipmentSpray, mop, wipe 1/2-1 1/2 oz. pergallon of water, wetsurface. 10 minutecontact time.216400 61282-53SolubleConcentrate 9.97Agriculturalpremises andequipmentSwine farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates cabs and wheels HaltersSpray, mop, wipe 1/2-1 1/2 oz. pergallon of water, wetsurface. 10 minutecontact time.216400 61282-53SolubleConcentrate 9.97Agriculturalpremises andequipmentHorse Stables Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2-1 1/2 oz. pergallon of water, wetsurface. 10 minutecontact time.216400 61282-53SolubleConcentrate 9.97Agriculturalpremises andequipmentFarm premises andequipmentHard non porous areas, including,walls, floors and premisesFog 1/2-1 1/2 oz. pergallon of water, wetsurface. 10 minutecontact time.Preclean premises and close off area to be treated.Do not allow people to contact or breathe fog. Donot enter until product has settled. Ventilate areasthoroughly.216400 62296-1SolubleConcentrate 5.25Medical Premisesand EquipmentMedical Institutions,premises and equipmentUse on hard, nonporous surfacessuch as floors, walls, metal surfaces,painted surfaces, exterior bowlsurfaces, empty basins, showers,and lavatory fixturesSpray, mop, wipe 1 oz per 32 oz ofwater, 10 minutecontact time.Medical Premisesand EquipmentHospital semi-critical items Precleaning of Non-porousinstruments or appliancesprior toSpray, immersion 1 oz per 32 oz ofwater,10 minute216400 62296-1SolubleConcentrate 5.25q ppp pterminal sterilization,contact time.216400 62296-1SolubleConcentrate 5.25Medical Premisesand EquipmentBarber/beauty shopinstruments.Combs, brushes, razors, scissors Spray, immersion 1 oz per 32 oz ofwater, 10 minutecontact time.216400 62296-1SolubleConcentrate 5.25Medical Premisesand EquipmentDental Premises andequipmentUse on hard, nonporous surfacessuch as floors, walls, metal surfaces,painted surfaces, exterior bowlsurfaces, empty basins, showers,and lavatory fixturesSpray, mop, wipe 1 oz per 32 oz ofwater, 10 minutecontact time.216400 66171-1SolubleConcentrate 6.0Medical Premisesand EquipmentMedical Institutions,premises and equipmentHard, inanimate, nonporous surfacessuch as walls, floors, door handles,medical bed surfaces, bed frames,mattress springs, wheelchairs, lightswitches, linen carts, stretcherwheels, hampers, telephones,cleanup carts, bassinets, dressingSpray, mop, wipe 1/2 oz. per gallon ofwater, wet surface. 10minute contact time.182770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 66171-1SolubleConcentrate 6.0Agriculturalpremises andequipmentPoultry Premises andEquipmentFloors, walls, and equipment,including incubators, hatchers,setters, trays, racks, carts, sexingtables, delivery trucks, troughs, rack,feeding and watering bins, bucketsand fountains. , incubators. Vehiclesincluding mats, crates, cabs andwheels.Spray, mop, wipe 1/2 oz. per gallon ofwater, wet surface. 10minute contact time.216400 66171-1SolubleConcentrate 6.0Agriculturalpremises andequipmentPoultry Premises andEquipmentHatchery rooms Fog 1/2 gallon to 2.5gallons water inapproved foggerappliance. Oneminute per 4 000 cuPreclean premises and close off area to be treated.Do not allow people to contact or breathe fog. Donot enter until product has settled. Ventilate areasthoroughly.216400 66171-1SolubleConcentrate 6.0Agriculturalpremises andequipmentShoe Baths Entrances to buildings and livestockhousing areas.Spray, mop, wipe 1/2 oz. per gallon ofwater, wet surface. 10minute contact time.216400 66171-1SolubleConcentrate 6.0Residential andpublic accesspremisesDog and Cat Kennels Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2 oz. per gallon ofwater, wet surface. 10minute contact time.216400 66171-1SolubleConcentrate 6.0Residential andpublic accesspremisesday care facilities, schools,hotels, motels, restaurants,Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2 oz. per gallon ofwater, wet surface. 10minute contact time.216400 66171-1SolubleConcentrate 6.0Medical Premisesand EquipmentVeterinary hospitals,clinics, premises andequipmentInstrument trays, operating tables,and other hard, nonporous premisesand surfaces, including, walls andfloors.Spray, mop, wipe 1/2 oz. per gallon ofwater, wet surface. 10minute contact time.Agriculturalpremises andequipmentCattle farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringli V hi l i l di tSpray, mop, wipe 1/2 oz. per gallon ofwater, wet surface. 10minute contact time.216400 66171-1SolubleConcentrate 6.0appliances.Vehiclesincluding mats,crates, cabs and wheels. Halters,ropes and other types of equipment216400 66171-1SolubleConcentrate 6.0Agriculturalpremises andequipmentSwine farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates cabs and wheels HaltersSpray, mop, wipe 1/2 oz. per gallon ofwater, wet surface. 10minute contact time.216400 66171-1SolubleConcentrate 6.0Agriculturalpremises andequipmentHorse Stables Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2 oz. per gallon ofwater, wet surface. 10minute contact time.216400 66171-1SolubleConcentrate 6.0Agriculturalpremises andequipmentFarm premises andequipmentHard non porous areas, including,walls, floors and premisesFog 1/2 oz. per gallon ofwater, wet surface. 10minute contact time.Preclean premises and close off area to be treated.Do not allow people to contact or breathe fog. Donot enter until product has settled. Ventilate areasthoroughly.216400 66171-1SolubleConcentrate 6.0Medical Premisesand EquipmentHospital semi-critical items Precleaning of Non-porousinstruments or appliances prior toterminal sterilizationSpray, immersion 1/2 oz. per gallon ofwater, wet surface. 10minute contact time.192770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 66171-1SolubleConcentrate 6.0Medical Premisesand EquipmentHospital Laundry Laundry, linens, blankets and diapers Pour 1 oz. per gallon ofwater, soak laundry.10 minute contacttime.Pre-wash treatment.216400 66171-2SolubleConcentrate 3.0Medical Premisesand EquipmentMedical Institutions,premises and equipmentHard, inanimate, nonporous surfacessuch as walls, floors, door handles,medical bed surfaces, bed frames,mattress springs, wheelchairs, lightswitches, linen carts, stretcherwheels, hampers, telephones,cleanup carts, bassinets, dressingSpray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 66171-2SolubleConcentrate 3.0Agriculturalpremises andequipmentPoultry Premises andEquipmentFloors, walls, and equipment,including incubators, hatchers,setters, trays, racks, carts, sexingtables, delivery trucks, troughs, rack,feeding and watering bins, bucketsand fountains. , incubators. Vehiclesincluding mats, crates, cabs andwheels.Spray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 66171-2SolubleConcentrate 3.0Agriculturalpremises andequipmentPoultry Premises andEquipmentHatchery rooms Fog 1 gallon to 2.5 gallonswater in approvedfogger appliance. Oneminute per 4,000 cu.FtPreclean premises and close off area to be treated.Do not allow people to contact or breathe fog. Donot enter until product has settled. Ventilate areasthoroughly.216400 66171-2SolubleConcentrate 3.0Agriculturalpremises andequipmentShoe Baths Entrances to buildings and livestockhousing areas.Spray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.S l blResidential andpublic accesspremisesDog and Cat Kennels Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time216400 66171-2SolubleConcentrate 3.0premisesminutecontacttime.216400 66171-2SolubleConcentrate 3.0Residential andpublic accesspremisesday care facilities, schools,hotels, motels, restaurants,Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 66171-2SolubleConcentrate 3.0Medical Premisesand EquipmentVeterinary hospitals,clinics, premises andequipmentInstrument trays, operating tables,and other hard, nonporous premisesand surfaces, including, walls andfloors.Spray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 66171-2SolubleConcentrate 3.0Agriculturalpremises andequipmentCattle farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates, cabs and wheels. Halters,ropes and other types of equipmentSpray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 66171-2SolubleConcentrate 3.0Agriculturalpremises andequipmentSwine farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates cabs and wheels HaltersSpray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.202770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 66171-2SolubleConcentrate 3.0Agriculturalpremises andequipmentHorse Stables Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 66171-2SolubleConcentrate 3.0Agriculturalpremises andequipmentFarm premises andequipmentHard non porous areas, including,walls, floors and premisesFog 1 oz. per gallon ofwater, wet surface. 10minute contact time.Preclean premises and close off area to be treated.Do not allow people to contact or breathe fog. Donot enter until product has settled. Ventilate areasthoroughly.216400 66171-2SolubleConcentrate 3.0Medical Premisesand EquipmentHospital semi-critical items Precleaning of Non-porousinstruments or appliances prior toterminal sterilizationSpray, immersion 1 oz. per gallon ofwater, wet surface. 10minute contact time.216400 66171-2SolubleConcentrate 3.0Medical Premisesand EquipmentHospital Laundry Laundry, linens, blankets and diapers Pour 1 oz. per gallon ofwater, soak laundry.10 minute contacttime.Pre-wash treatment.216400 70385-7SolubleConcentrate 4.9Medical Premisesand EquipmentMedical premises, floors Carpets Hot water extraction,spin bonnet,immersion2-4 oz per gallon ofwater216400 70385-7SolubleConcentrate 4.9Residential andpublic accesspremisesResidential and publicaccess premises, floorsCarpets Hot water extraction,spin bonnet,immersion2-4 oz per gallon ofwaterCommercial , Commercial , institutional, Carpets Hot water extraction, 2-4 ozpergallon of216400 70385-7SolubleConcentrate 4.9institutional, andindustrial premisesand industrial premises,floorspspin bonnet,immersionp gwater216400 70627-6SolubleConcentrate 10.5Medical Premisesand EquipmentMedical Institutions,premises and equipmentUse on hard, nonporous surfacessuch as floors, walls, metal surfaces,painted surfaces, exterior bowlsurfaces, empty basins, showers,conductive flooring and lavatoryfixtures.Spray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 70627-6SolubleConcentrate 10.5Medical Premisesand EquipmentDental Premises andequipmentUse on hard, nonporous surfacessuch as floors, walls, metal surfaces,painted surfaces, exterior bowlsurfaces, empty basins, showers,conductive flooring and lavatoryfixtures.Spray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 70627-6SolubleConcentrate 10.5Agriculturalpremises andequipmentPoultry Premises andEquipmentFloors, walls, and equipment,including incubators, hatchers,setters, trays, racks, carts, sexingtables, delivery trucks, troughs, rack,feeding and watering bins, bucketsand fountains. , incubators. Vehiclesincluding mats, crates, cabs andwheels.Spray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.212770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 70627-6SolubleConcentrate 10.5Food handlingprocessingequipment andpremisesMeat and poultryprocessing plantsHard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.Food products and packaging materials must beremoved from the room or carefully protected. Useproduct in accordance with its label. All surfacesmust be thoroughly rinsed with potable water.216400 70627-6SolubleConcentrate 10.5Agriculturalpremises andequipmentShoe Baths Entrances to buildings and livestockhousing areas.Spray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 70627-6SolubleConcentrate 10.5Residential andpublic accesspremisesDay care facilities, schools,hotels, motels, restaurantsHard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 70627-6SolubleConcentrate 10.5Residential andpublic accesspremisesDog and Cat Kennels Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 70627-6SolubleConcentrate 10.5Medical Premisesand EquipmentVeterinary hospitals,clinics, premises andequipmentInstrument trays, operating tables,and other hard, nonporous premisesand surfaces, including, walls andfloors.Spray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 70627-6SolubleConcentrate 10.5Agriculturalpremises andequipmentCattle farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates, cabs and wheels. Halters,ropes, and other types of equipmentused in handling and restraininganimalsSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 70627-6SolubleConcentrate 10.5Agriculturalpremises andequipmentSwine farm premises andequipmentFloors, walls, and equipment, pens,stalls, chutes, troughs, racks, andother feeding and wateringappliances. Vehicles including mats,crates, cabs and wheels. Halters,ropes, and other types of equipmentused in handling and restraininganimalsSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.a as216400 70627-6SolubleConcentrate 10.5Agriculturalpremises andequipmentHorse Stables Hard non porous areas, including,walls, floors and premisesSpray, mop, wipe 1/2 oz. per gallon ofwater, 10 minutecontact time.216400 67869-38SolubleConcentrate 10IndustrialProcesses andWater SystemsIndustrial recirculating watercooling towers andevaporative condenserCooling tower and evaporativecondenser sump or basinsMetered pump 2-8 pt. per 1000gallons (250-1000ppm)216400 67869-38SolubleConcentrate 10IndustrialProcesses andWater SystemsIndustrial process water Pipework, heat exchangers, andcondenser tube sumps and tanksOpen pour, meteredpump0.8-8.0 pt. per 1000gallons (100-1000ppm) up to onceweekly216400 67869-38SolubleConcentrate 10IndustrialProcesses andWater SystemsPaper mill process water Paper and paperboard process water Open pour, meteredpump0.2 to 3.0 pt per ton(10-250ppm) offinished paper up tothree time per day216400 67869-38SolubleConcentrate 10IndustrialProcesses andWater SystemsIndustrial and/or commercialair commercial airconditioning and humidifyingsystemsA/C and humidifying systems Open pour, meteredpump3.8-7.6 pts. Per 1000gallons (50-100ppm)222770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 67869-38SolubleConcentrate 10IndustrialProcesses andWater SystemsOil and gas fluids terrestrial and offshore drilling muds,fluids and gelsOpen pour, meteredpump4-8 pt. per 1000gallons (500-1000ppm)216400 67869-38SolubleConcentrate 10IndustrialProcesses andWater SystemsOil process water Oil and gas well injection andformation watersOpen pour, meteredpump2-8 pt. per 1000gallons (250-1000ppm) up to onceper week216400 67869-38SolubleConcentrate 10IndustrialProcesses andWater SystemsOil and gas pipeline andtank maintenanceWater bottoms an crude and refinedhydrocarbon storage tanks, pipingand transportations systemsMetered pump 2-16 pt. per 1000gallons (250-2000ppm) up to onceper day216400 67869-38SolubleConcentrate 10MaterialpreservativesMetalworking fluids Soluble oils, semi-synthetic andsynthetic fluidsOpen pour, meteredpump2.5-10 gallons per1000 gallons (2500-10000ppm) up toonce per day216400 67869-38SolubleConcentrate 10MaterialpreservativesPaper Mills Bulk Pulp Open pour, meteredpump4-16pt. per 1000gallons (500-2000ppm) up to onceper week216400 67869-38SolubleConcentrate 10MaterialpreservativesAdhesives Non-food contact adhesives Open pour, meteredpump1-5 pt per 100lb byweight216400 67869-38SolubleConcentrate 10MaterialpreservativesAbsorbent Clays Absorbent Clays Open pour, meteredpump0.4-0.2 oz per 100 lbsby weightMaterialpreservativesWater based suspensionconcentrates, Paints andother emulsionsStarch, pigment and mineral slurries,acrylic, slyrene acrylic, polyvinylacetate and other latex emulsion,Open pour, meteredpump8-40 pt. per 1000gallons (1000-5000ppm)upto once216400 67869-38SolubleConcentrate 10latex emulsion based paints,photographic emulsion, silicone andother antifoam emulsion systemspp ) pper week216400 67869-38SolubleConcentrate 10MaterialpreservativesWater based printing inksand fount solutionsFountain solutions Open pour, meteredpump8-40 pt. per 1000gallons (1000-5000ppm) up to onceper week216400 67869-38SolubleConcentrate 10MaterialpreservativesIn can preservation. Water based printing inks and fountsolutionsOpen pour, meteredpump4-8pt. per 1000gallons (500-1000ppm) up to onceper week216400 68708-9Ready-to-UseSolution 8.8MaterialpreservativesWater based suspensionconcentratesStarch, pigment and extender slurries Open pour, meteredpump8-40 pint per 1000gallons (1000-5000ppm)216400 68708-9Ready-to-UseSolution 8.8MaterialpreservativesLatex emulsionconcentrates and emulsionbased paintsPaints and latex emulsion systems Open pour, meteredpump8-40 pint per 1000gallons (1000-5000ppm)232770,BronopolAppendix APC Code EPA RegNumberused forMax. Appl.RateFormulation % ActiveIngredient inEnd UseFormulationUse Category Use Site TreatmentSite/Surfaces Method ofApplicationMax Application/UseRateUse Limitations216400 68708-9Ready-to-UseSolution 8.8MaterialpreservativesAntifoam emulsions Defoamers Open pour, meteredpump8-40 pint per 1000gallons (1000-5000ppm)216400 68708-9Ready-to-UseSolution 8.8Materialpreservativeswater based coatings Paper coatings Open pour, meteredpumpNone listed.216400 74655-14Ready-to-UseSolution 5.3IndustrialProcesses andWater SystemsPulp and paper watersystemsPulp and paper milland additivesystemsOpen pour, meteredpump3.0-20.8 lbs per 1000gallons (360-2500ppm), maximum5.0 lbs. per ton of pulpor paper produced.Non-food contact216400 74655-14Ready-to-UseSolution 5.3MaterialpreservativesPapermaking Defoamers Open pour, meteredpump2500-3000ppm Non-food contact216400 74655-14Ready-to-UseSolution 5.3MaterialpreservativesPapermaking Clay Open pour, meteredpump2500-3000ppm Non-food contact216400 74655-14Ready-to-UseSolution 5.3MaterialpreservativesPapermaking Starch, broke and calcium carbonate Open pour, meteredpump650-750ppm Non-food contact216400 74655-14Ready-to-UseSolution 5.3MaterialpreservativesPapermaking Alum Open pour, meteredpump350-450ppm Non-food contactMaterialtiPapermaking Dyes and titanium oxide Open pour, metered 40-80ppm Non-food contact216400 74655-14Ready-to-UseSolution 5.3preservativespump216400 74655-14Ready-to-UseSolution 5.3MaterialpreservativesPapermaking Emulsions, adhesives and polymers Open pour, meteredpump200-300ppm Non-food contact24