AGREEMENT



         AGREEMENT  made and entered  into as of the 15th day of March,  1999 by
and  between  East  Coast  Angels,  L.L.C.  ("East  Coast"),  a Florida  Limited
Liability  Company,  and  IXION  BIOTECHNOLOGY,  INC.,  a  Delaware  corporation
("Company").

         WHEREAS,  Company intends to (a) obtain additional  financing by making
an offering  ("Offering")  consisting  of a private  placement of the  Company's
stock or other  securities  with investors  introduced to Company solely by East
Coast (each an "Investor");  (b) enter into a strategic  alliance with an entity
introduced  to Company  solely by East Coast  ("Strategic  Alliance")  which may
include,  but is not limited to, a  relationship  with a  corporate  partner,  a
commitment to provide funding,  or the sale of equity or other  securities;  and
(c) enter into a merger,  consolidation or sale of all or  substantially  all of
the Company's  assets with an entity  introduced to Company solely by East Coast
("Business Combination"); and

         WHEREAS, East Coast is willing to assist Company with Transactions;

         NOW  THEREFORE,  in  consideration  of  the  premises  and  the  mutual
covenants contained herein, the undersigned agree as follows:

1. TERM OF AGREEMENT. This Agreement shall have a term ("Agreement Term") of six
months,  beginning on the date first above written, 1999, unless extended by the
mutual written agreement of both parties.

2. DUTIES OF EAST COAST. East Coast's sole function shall be to:

         a.  Act as a  nonexclusive  finder,  that  is to  identify  prospective
Resources  and  make   introductions   of  such   Resources  to  Company.   Such
introductions shall be in writing. However, in performing such duties East Coast
shall not evaluate or endorse the merits of any investment,  Strategic  Alliance
or  Business  Combination   opportunity   presented  to  Company  and  makes  no
recommendations  or  endorsements  regarding the  appropriateness  of particular
investment,   Strategic  Alliance  or  Business  Combination  opportunities  for
particular  Resources.  Potential  Resources  must  rely on their  own  judgment
regarding  the merits of a particular  opportunity.  Potential  resources  shall
conduct  their  own  independent  investigation  of the  Company  and the  facts
submitted  by the  Company to make an  informed  decision.  East Coast shall not
become  involved  with any  negotiations  between  Company and Resources or with
structuring any transaction.  Additionally, East Coast will not handle any funds
or securities involved in completing the transaction.

3.  RIGHTS OF EAST  COAST.  If at any time during a period of one year after the
expiration  of the  Agreement  Term,  including  extensions,  Company  closes  a
Transaction  with any Resource or any "Affiliate" (as defined below) of any such
Resource that was introduced solely (or if not solely, then introduced first) by
East Coast,  East Coast shall be  entitled to  remuneration  as provided in this
Agreement  with respect to such  Transaction  with such  Resource or  Affiliate.
"Affiliate"  for  purposes of this  Agreement  shall mean a person or entity who
controls, is controlled by, or is under common control with a Resource.



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4. EXPENSES.  You agree to pay us an initial  retainer  deposit of  One-thousand
dollars ($1,000) upon execution of this Agreement. You authorize us to use those
funds to pay costs and  expenses in  connection  with  performing  our  services
including,  but not limited to:  outside  consulting  fees,  messenger and other
delivery fees, overnight delivery fees, and travel expenses.  Such expenses will
be  itemized.   Un-expended   funds  shall  be  returned  to  the  Company  upon
termination.  Any other  charges above this amount shall be subject to Company's
approval.

5.       REMUNERATION.

         a. Upon closing of a  transaction  consistent  with the time and rights
pursuant to paragraph 3 of this Agreement, with a Resource or an Affiliate, East
Coast shall be entitled to receive at closing  from funds  provided  through the
transaction  a  finder's  fee  equal to Ten (10)  percent  of the  funds  raised
("Fee").  If there is more than one closing,  East Coast shall  receive a Fee at
each closing. The Fee shall be in the same form as the funds raised.

         b. If a Transaction is not consummated with a Resource,  or with any of
their  Affiliates,  East  Coast  shall  not  be  entitled  to a Fee  under  this
Agreement.

         c. In the event that the Company consummates a Strategic Alliance,  the
total consideration upon which the Fee is based shall include,  but shall not be
limited to: (a) payments made for assets,  (b) payments made for equity or other
securities,  (c)  future  payments  for which the  partner is  obligated  either
absolutely or upon the attainment of expressly specified milestones, (d) funding
by the partner  (through  reimbursement or otherwise) of any expenditures of the
Company and (e) all future profits for any services  provided by the Company for
the  Strategic  Alliance  which are  purchased  over a period of time.  Each Fee
received shall be aggregated  with previous Fees received under this  Agreement.
The Fee shall be calculated using the sum of the above  categories,  (a) through
(e),  commencing on the first day of the Strategic  Alliance using the following
percentages over the specified time periods:

         1.       5% for the first twelve months (1st day through 12th month);
         2.       4% for the next twelve months (12th month plus one day 
                     through 24th month);and
         3.       3% for the next twelve months (24th month plus one day 
                     through the 36th month).

6. REPRESENTATIONS.  The acts, statements and representations made by Company to
Resources  and East Coast are the sole  responsibility  of Company,  and Company
agrees to indemnify East Coast for any liability,  claims,  losses and expenses,
including  legal  expenses,  incurred by East Coast that  result from  Company's
representations which are materially incomplete,  false, or misleading.  Company
represents  that all materials  provided to East Coast regarding the Transaction
are truthful and accurate in all material respects.  East Coast warrants that it
will be the only finder  entitled  to a fee in  connection  with a  Transaction,
unless other finders are disclosed in advance and accepted by Company.

7.  AUTHORITY.  Company  represents that it has the authority to enter into this
Agreement, and all parties executing this Agreement have been duly authorized by
the Company.

8. ADR; WAIVER OF JURY TRIAL.  Neither party shall institute a proceeding in any
court or  administrative  agency to resolve a dispute between the parties before
that party has sought to resolve the dispute  through direct  negotiations  with
the other  party.  If the  dispute is not  resolved  within  three weeks after a
demand for direct negotiation,  the parties shall attempt to resolve the dispute
through  mediation under the Center for Public Resources ("CPR") Model Procedure
for Mediation of Business Disputes in effect on the date of this agreement.  The
parties will select a mediator with the assistance of the CPR. Unless  otherwise
agreed,  the parties will select a mediator from the CPR Panels of Distinguished
Neutrals. Any controversy or claim arising out of or relating to this agreement,
or the breach, termination, or validity thereof, shall be settled by arbitration
by a sole  arbitrator  in  accordance  with the CPR Rules  for  Non-Administered
Arbitration,  and judgement  upon the award  rendered by the  arbitrator  may be
entered by any court having jurisdiction  thereof. All parties to this Agreement
agree to waive the right  either may have to a trial by jury with respect to any
litigation in any way related to this Agreement.


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9. ENTIRE  AGREEMENT.  This Agreement  constitutes the entire  Agreement of, and
supersedes  any prior  agreements or  understandings  between,  the parties.  No
amendment,  alteration or withdrawal of this Agreement shall be valid or binding
unless  made in writing  and signed by the  parties.  Any  purported  amendment,
modification  or  withdrawal  which  is  oral  shall  be void  and of no  effect
whatsoever.

10. CHOICE OF LAWS;  VENUE. This Agreement shall be governed by and construed in
accordance with the laws of the State of Florida, exclusive of its choice-of-law
principles;  and any suit,  action or  proceeding  arising out of or relating to
this  Agreement  may be  commenced  and  maintained  in any  court of  competent
jurisdiction in Palm Beach County, Florida, and each party waives all objections
to such jurisdiction and venue.

11.      CONTINUING EFFECT.   Sections 6 and 10 shall survive the expiration or
termination of this Agreement.

12. ENFORCEABILITY AND SEVERABILITY.  In the event that any term or provision of
this  Agreement  is found to be invalid,  illegal or  unenforceable,  such event
shall in way impair the other terms and provisions of this Agreement.

13.  NOTICES.  All legal notices  required under this Agreement  shall be deemed
sufficient  if forwarded to the parties by certified  mail,  and shall be deemed
received upon the third business day after mailing. Such notices shall be mailed
as follows:

                               If to East Coast:

                              Edwards & Angell, LLP
                            Attention: Michael Heller
                          250 Royal Palm Way, Suite 300
                            Palm Beach, Florida 33480

                               If to Company:

                            Ixion Biotechnology, Inc.
                          13709 Progress Blvd., Box 13
                             Alachua, Florida 32615


14. EXECUTION OF AGREEMENT. This Agreement may be executed in counterparts.


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        IN WITNESS  WHEREOF,  the  parties  have caused  this  Agreement  to be
executed as of the date first above written.

                                           EAST COAST ANGELS, L.L.C.


                                           By:                        
                                           Lanny K. Marks, Secretary




                                           By: 
                                           Weaver H. Gaines
                                           Chairman and Chief Executive Officer