Fluoxastrobin 

PC Code: 028869 Dietary Exposure and Risk Assessment DP Number: 409517 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

MEMORANDUM 

DATE: 03/21/2013 

OFFICE OF CHEMICAL SAFETY 

AND POLLUTION PREVENTION 

SUBJECT: Fluoxastrobin: Chronic Dietary (Food and Drinking Water) Exposure 

Assessments for the Section 3 Registration Action Uses on Melon 

Subgroup 9A, Sorghum, and Wheat. Amendments to Established 

Tolerances on Milk and Milk Fat. 

PC Code: 028869 

Decision Nos.: 465774, 473405 

Petition Nos.: 2F8047, 2F8 130 

Risk Assessment Type: Dietary 

TXRNo.: NA 

MRIDNo.: NA 

REVIEWER: Meheret Negussie, Chemist 

Risk Assessment Branch III 

Health Effects Division (7509P) 

DP Barcode: D409517 

Registration No.: 66330-64 

Regulatory Action: Section 3 

Registration 

Case No.: NA 

CAS No.: 361377-29-9 

40 CFR: §180.609 

THROUGH: Sheila Piper, Senior Chem~'s t ~ - ~.vJ Seyed Tadayon, Chemist 

Dietary Exposure Science A visory Council (DESAC) 

Health Effects Division (7509P) 

TO: Christine Olinger, Branch Chief 

Nancy Tsaur, Chemist/Risk Assessor 

Risk Assessment Branch III 

Health Effects Division (7509P) 

William Cutchin/Heather Garvie, RM Team #20 

Registration Division (7505P) 

Pagelofl3 
Fluoxastrobin 

PC Code: 028869 Dietary Exposure and Risk Assessment DP Number: 409517 

Executive Summary 

Chronic aggregate dietary (food and drinking water) exposure and risk assessment was 

conducted using the Dietary Exposure Evaluation Model software with the Food 

Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 

food consumption data from the U.S. Department of Agriculture,s (USDA's) National 

Health and Nutrition Examination Survey, What We Eat in America, 

(NHANES/WWEIA). The analyses were conducted in support of a human health risk 

assessment for the proposed Section 3 requests on melon subgroup 9A, sorghum, wheat 

and to amend the established tolerances of milk and milk fat. This memorandum was 

reviewed by two peer reviewers of the DESAC, per DESAC SOP 2012.1. 

Acute Dietary Exposure Results and Characterization: 

No toxic effects attributable to a single exposure to fluoxastrobin have been identified; 

therefore, an acute reference dose (aRID) has not been established and an acute dietary 

exposure assessment was not conducted. 

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization 

A partially refined dietary exposure assessment was performed for fluoxastrobin. The 

assumptions of this dietary assessment include tolerance level residues, average field trial 

residues and 100% crop treated (CT). DEEM version 7.81 default processing factors 

were assumed except for where tolerances were established for processed commodities or 

when processing studies showed no concentration. Estimated drinking water 

concentration (EDWC) values were also incorporated. The estimated ground water post 

breakthrough average concentration of 137 J..Lg/L was incorporated directly into the 

dietary assessment. The results of the chronic dietary analysis for food and drinking 

water are below the Agency's level of concern (LOC) for all population subgroups. The 

dietary exposure for food and water is estimated at 30% of the chronic Population 

Adjusted Dose (cPAD) for the general U.S. population and 66%, of the cPAD for all 

infants < 1 year old, the population subgroup with the highest estimated chronic dietary 

exposure to fluoxastrobin. 

Cancer Dietary Exposure Results and Characterization 

The Cancer Assessment Review Committee (CARC) recently concluded that 

fluoxastrobin is "not likely to be carcinogenic to humans;" therefore, cancer risk was not 

assessed. 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For 

acute and chronic assessments, the risk is expressed as a percentage of a maximum 

acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable 

adverse health effects). This dose is referred to as the population adjusted dose (PAD). 

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Fluoxastrobin

PC Code: 028869 Dietary Exposure and Risk Assessment DP Number: 409517

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The PAD is equivalent to the reference dose point of departure (POD, NOAEL, LOAEL) 

divided by the required uncertainty and safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary 

risk exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk 

exceeds one in one million. References which discuss the acute and chronic risk 

assessments in more detail are available on the EPA/pesticides web site: “Available 

Information on Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web 

link: http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 

99.6 (8/20/99).

This dietary assessment is an update to the fluoxastrobin dietary assessment (D402506, 

M. Negussie, 06/19/2012). 

II. Residue Information

Fluoxastrobin is a fungicide used for the control of fungal diseases in tuberous and corm 

vegetables, fruiting vegetables, the leaf petiole vegetables, low growing berries, squash 

and cucumbers, field and sweet corn, peanuts, soybeans, wheat, rice, and as a seed 

treatment for potato and peanut, and for soilborne/seedling disease control. Tolerances 

for combined residues of fluoxastrobin and its Z-isomer in/on primary crop commodities 

are established under 40 CFR §180.609(a)(1) at levels ranging from 0.010 ppm to 60 

ppm. Tolerances are established under 40 CFR §180.609(a)(2) for the combined residues 

of fluoxastrobin, its Z-isomer, and its phenoxy-hydroxypyrimidine metabolite, 6-(2-

chlorophenoxy)-5-fluoro-4-pyrimidinol, in cattle, goat, hog, horse, and sheep 

commodities and poultry liver at levels ranging from 0.02 ppm (milk) to 0.50 ppm (milk 

fat). 

The residues of concern in primary crops, rotational crops, and livestock, for tolerance 

enforcement and risk assessment are as follows: primary crops/rotational cropsfluoxastrobin and its Z-isomer; livestock- fluoxastrobin, its Z-isomer and 6-(2-

chlorophenoxy)-5-fluoro-4-pyrimidinol (DP289106, W. Wassell, 01/25/2005). 

Table 1 is a summary of the HED recommended food tolerances resulting from the 

proposed uses on melon subgroup 9A, sorghum, wheat and amend the established 

tolerances of milk and milk fat (DP403571, M. Negussie, 03/21/2013).

Table 1. Summary of Proposed Tolerances for Fluoxastrobin

Commodity Proposed

Tolerance 

(ppm)

Recommended Tolerance 

(ppm)

Comments [Correct Commodity 

Definition]

Melon, subgroup 9A 1.5 1.5 Melon subgroup 9A

Sorghum grain 1.5 1.5 Sorghum, grain

Wheat, grain 0.15 0.15

Wheat, bran 0.15

Established

None Revoke. The recommended 

tolerance on wheat, grain will cover 
Fluoxastrobin

PC Code: 028869 Dietary Exposure and Risk Assessment DP Number: 409517

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Table 1. Summary of Proposed Tolerances for Fluoxastrobin

Commodity Proposed

Tolerance 

(ppm)

Recommended Tolerance 

(ppm)

Comments [Correct Commodity 

Definition]

expected residues in wheat bran. 

Livestock Tolerances That Need to be Revised

Commodity Established

Tolerance 

(ppm)

Proposed 

Tolerance 

(ppm)

Recommended 

Tolerance 

(ppm)

Milk 0.02 0.03 0.03

Milk, fat 0.50 0.75 0.75

Residue Data used for Chronic Assessments:

Tolerance level residues, average field trial residues, and 100% CT were assumed. 

Average field trial residues were used for melon subgroup 9A, berry low growing 

subgroup 13-07G, leaf petioles subgroup 4B, rice, squash/cucumber subgroup 9B, and 

vegetable fruiting group 8. Based on processing studies, the processing factors for 

tomato puree, potato chips, dried potato (granules/flakes), and potato flour were reduced 

to 1. Separate tolerances were set for peanut oil and tomato paste; therefore, the 

processing factors for these commodities were set at 1 (DP289106, W.D. Wassell, 

01/25/2005). DEEMTM version 7.81 default processing factors were assumed for all 

other processed commodities for which they were available. Field trial data were 

translated from the representative commodities to the non-representative commodities 

according to HED SOP 2000.1:”Guidance for Translation of Field Trial Data from 

Representative Commodities in the Crop Group Regulation to other Commodities in 

Each Crop Group/Subgroup.” Table 2 is a summary of the average residues and Table 3

is a summary of the processing factors used in the dietary assessment.

Table 2. Summary of Average Residues Used for Fluoxastrobin.

Commodity Established

Tolerance (ppm)

Average Residues

(ppm)

Melon, subgroup 9A 1.5 0.282

Berry, low, growing, subgroup 13-

07G

1.9 0.56

Leaf petioles subgroup 4B 4.0 2.09

Rice, grain 4.0 1.177

Squash/cucumber 9B 0.50 Cucumber-0.09

Summer Squash-0.08

Vegetable, fruiting, group 8 1.0 Tomato-0.203

Pepper-0.214
Fluoxastrobin

PC Code: 028869 Dietary Exposure and Risk Assessment DP Number: 409517

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Table 3. Processing Factors (PF) for Fluoxastrobin Dietary Risk Assessment.

Processed Commodity PF Source

Beef, meat, dried 1.92 DEEM Default

Corn grain, sugar/hfcs 1.5 DEEM Default

Cranberry, juice 1.1 DEEM Default

Peanut, butter 1.89 DEEM Default

Peanut, oil 1.0 Tolerance for peanut, oil 

accounts for processing.

Potato, dried and flour 1.0 Processing Study

Tomato, dried 14.3 DEEM Default

Tomato, juice 1.5 DEEM Default

Tomato, paste 1.0 Tolerance for tomato, paste 

accounts for processing.

Tomato, puree 1.0 Processing Study

III. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED); (DP403757, R. Bohaty, 02/05/2013)

and incorporated directly into this dietary assessment. Water residues were incorporated 

in the DEEM-FCID into the food categories “water, direct, all sources” and “water, 

indirect, all sources.”

EDWCs for surface water are based on the Tier II model. Based on this model estimate, 

the proposed uses of fluoxastrobin on melon and sorghum may result in a peak 

concentration of 48.7 μg/L and 1 in 10 year annual average concentration of 7.9 ug/L in 

surface water. The previous EDWC of 93 μg/L estimated for rice is higher than the 

EDWC resulting from the proposed uses.

Reevaluation of the turf use using the Wisconsin scenario (the use with the highest single 

maximum application rate, as well as the highest yearly application rate) using PRZMGW1

indicates that continued use of fluoxastrobin over many years (based on a 100 year 

simulation with 100 years of repeated applications) at the maximum label rates for turf 

may result in groundwater concentrations that are greater than EDWCs previously 

reported for surface water as shown in Table 5.

Table 4. Tier II Surface Water Estimated Drinking Water Concentrations Resulting From the 

Proposed Use of Fluoxastrobin on Melon and Sorghum.

Parameter Tier II Surface Water (μg/L)

Melons Sorghum Turf

Acute

1-in-10 Year Peak Concentration

μg/L 

48.7 7.0 24.8

Chronic

1-in-10 Year Annual Average Concentration 7.9 4.6 18.6

 

1 PRZM-GW was recently (12/2012) approved for standard use in drinking water assessments are a Tier I 

and Tier II exposure tool. 
Fluoxastrobin

PC Code: 028869 Dietary Exposure and Risk Assessment DP Number: 409517

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μg/L 

Cancer

30 Year Annual Average Concentration

μg/L 

5.0 3.5 12.2

Table 5. Tier I Groundwater Estimated Drinking Water Concentrations 

Resulting From the Proposed Use of Fluoxastrobin on Melon and Sorghum.

Parameter Tier I Groundwater (μg/L)

Melons Sorghum Turf

Peak Concentration

μg/L 47.1a

15.3 a146 a

Post Breakthrough Average 

Concentration

μg/L 

44.2 a14.3 a

137 a

Average Breakthrough Time

(days) 14529 b

14529 b14529 b

a.extended weather file used; 100 year simulation with100 years of repeated applications

b.Reported for the scenario with the shortest average breakthrough time. The reported values are not 

from the scenario for which the EDWCs are reported.

Bold font indicates most conservative values for all fluoxastrobin uses.

IV. DEEM-FCID Program and Consumption Information

Fluoxastrobin chronic dietary exposure assessment was conducted using the DEEMFCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA’s 

NHANES/WWEIA. The data are based on the reported consumption of more than 

20,000 individuals over two non-consecutive survey days. Foods “as consumed” (e.g., 

apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit -

cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly 

available recipe translation files developed jointly by USDA/ARS and EPA. For chronic 

exposure assessment, consumption data are averaged for the entire U.S. population and 

within population subgroups. However, for acute exposure assessment, consumption 

data are retained as individual consumption events. Based on analysis of the 2003-2008 

WWEIA consumption data, which took into account dietary patterns and survey 

respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, 

children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 

years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or 

food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied 

by the average daily consumption estimate for that food/food form to produce a residue 

intake estimate. The resulting residue intake estimate for each food/food form is summed 

with the residue intake estimates for all other food/food forms on the commodity residue 

list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg 

body weight/day and as a percent of the cPAD. This procedure is performed for each 

population subgroup.
Fluoxastrobin

PC Code: 028869 Dietary Exposure and Risk Assessment DP Number: 409517

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V. Toxicological Information

The toxicity endpoints pertinent for human dietary risk assessment are summarized in 

Table 6. 

Table 6. Summary of Toxicological Doses and Endpoints for Fluoxastrobin for Use in Dietary 

Exposure Risk Assessments.

Exposure/

Scenario

Dose Used in Risk 

Assessment, UF

FQPA SF and 

Endpoint for Risk 

Assessment

Study and Toxicological 

Effects

Acute Dietary 

(General Population) No acute endpoint was identified for the general population.

Acute Dietary

(Females 13-49 

years of age)

Chronic Dietary all 

Populations

NOAEL = 1.5 

mg/kg/day

UF = 100

Chronic RfD = 

0.015 mg/kg/day

FQPA SF = 1X

cPAD = chronic RfD

 FQPA SF

= 0.015 mg/kg/day

Chronic toxicity study with 

dogs.

LOAEL = M/F:8.1/7.7 

mg/kg/day based on body 

weight reductions and 

hepatocytomegaly and 

cytoplasmic changes associated 

with increased serum liver 

alkaline phosphatase indicative 

of cholestasis. 

Cancer (oral, 

dermal, inhalation) 

Classification: Not likely to be carcinogenic to humans.

NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF =

uncertainity factor. FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = 

chronic). RfD = reference dose. 

VI. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk 

exceeds 100% of the PAD. The DEEM-FCID analyses estimate the dietary exposure of 

the U.S. population and various population subgroups. The results reported in Table 7

are for the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, 

children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years. 

Results of Chronic Dietary Exposure Analysis

The results of the aggregate chronic dietary analysis for food and drinking water are 

below the Agency’s level of concern (<100% cPAD) for the general U.S. population 

(30% cPAD) and all population subgroups. The most highly exposed population 

subgroup is all infants < 1 year old at 66% of the cPAD. The results of the chronic 

dietary exposure analyses are reported in Table 7 below.
Fluoxastrobin

PC Code: 028869 Dietary Exposure and Risk Assessment DP Number: 409517

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Table 7. Result of Chronic Dietary Exposure and Risk Estimates for Fluoxastrobin.

1

Population Subgroup PAD, 

mg/kg/day

DEEM-FCID (food and water)

Exposure, mg/kg/day %PAD

Chronic Dietary Estimates

U.S. Population

0.015

0.004529 30

All infants (< 1 yr) 0.009886 66

Children 1-2 yrs 0.009516 63

Children 3-5 yrs 0.007496 50

Children 6-12 yrs 0.005052 34

Youth 13-19 yrs 0.003514 23

Adults 20-49 yrs 0.004226 28

Adults 50+ yrs 0.003999 27

Females 13-49 yrs 0.004118 28

1 The population subgroup with the greatest exposure is in bold

Cancer Dietary Exposure Results and Characterization

As noted above, the HED CARC has recently revisited the cancer classification for 

fluoxastrobin. HED has reclassified fluoxastrobin as “not likely to be carcinogenic to 

humans;” therefore cancer risk is not of concern. 

VIII. Characterization of Inputs/Outputs

The dietary exposure and risk estimates are partially refined since they assume average 

residues for most crops and include empirical processing factors. Additional refinements 

may be implemented such as the incorporation of %CT data, monitoring data, and 

inclusion of additional empirical processing factors. HED concludes that the chronic 

dietary exposure and risk estimates are not underestimated.

IX. Conclusions

Dietary risks for fluoxastrobin are below HED’s level of concern for dietary exposure 

and risk. All infants < 1 year old are the most highly exposed population subgroup for 

chronic exposure, with risks estimates at 66% of the cPAD. Risks were lower for all 

other population subgroups, including the general U.S. population which utilized 30% of 

the cPAD. The chronic dietary exposure assessment is not likely to underestimate 

exposure.

 X. List of Attachments

Attachment 1. Fluoxastrobin Chronic Dietary Analysis Input File - Food & Water

Attachment 2. Fluoxastrobin Chronic Dietary Analysis Results - Food & Water
Fluoxastrobin

PC Code: 028869 Dietary Exposure and Risk Assessment DP Number: 409517

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Attachment 1. Fluoxastrobin Chronic Dietary Analysis Input File - Food & Water

Filename: C:\Documents and Settings\MNEGUSSI\My Documents\DEEM Version 

3.16\Fluoxastrobin\MelonSorghum\FLUOXASTROBIN_TOL+WATER_Jan2013.R08

Chemical: Fluoxastrobin

RfD(Chronic): .015 mg/kg bw/day NOEL(Chronic): 1.5 mg/kg bw/day

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 02-27-2013/12:01:16 Program ver. 3.16, 03-08-d

Comment: New Use Melon and Sorghum; new EDWC 137 ppb Refinement-Rice, subgroup 4B, 

9A, 9B, 13-07G, group 8, 

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0103015000 1CD Arrowroot, flour 0.010000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.010000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.010000 1.000 1.000 

0103082000 1CD Cassava 0.010000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.010000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.010000 1.000 1.000 

0103166000 1CD Ginger 0.010000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.010000 1.000 1.000 

0103167000 1CD Ginger, dried 0.010000 1.000 1.000 

0103296000 1C Potato, chips 0.010000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 0.010000 1.000 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 0.010000 1.000 1.000 

0103298000 1C Potato, flour 0.010000 1.000 1.000 

0103298001 1C Potato, flour-babyfood 0.010000 1.000 1.000 

0103299000 1C Potato, tuber, w/peel 0.010000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.010000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.010000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.010000 1.000 1.000 

0103366000 1CD Sweet potato 0.010000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.010000 1.000 1.000 

0103371000 1CD Tanier, corm 0.010000 1.000 1.000 

0103387000 1CD Turmeric 0.010000 1.000 1.000 

0103406000 1CD Yam, true 0.010000 1.000 1.000 

0103407000 1CD Yam bean 0.010000 1.000 1.000 

0402076000 4B Cardoon 2.090000 1.000 1.000 

0402085000 4B Celery 2.090000 1.000 1.000 

0402085001 4B Celery-babyfood 2.090000 1.000 1.000 

0402086000 4B Celery, juice 2.090000 1.000 1.000 

0402087000 4B Celtuce 2.090000 1.000 1.000 

0402152000 4B Fennel, Florence 2.090000 1.000 1.000 

0402322000 4B Rhubarb 2.090000 1.000 1.000 

0402367000 4B Swiss chard 2.090000 1.000 1.000 

0600347000 6 Soybean, seed 0.050000 1.000 1.000 

0600349000 6 Soybean, soy milk 0.050000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 0.050000 1.000 1.000 

0600350000 6 Soybean, oil 0.050000 1.000 1.000 

0600350001 6 Soybean, oil-babyfood 0.050000 1.000 1.000 

0603348000 6C Soybean, flour 0.050000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 0.050000 1.000 1.000 

0801374000 8A Tomatillo 0.203000 1.000 1.000 

0801375000 8A Tomato 0.203000 1.000 1.000 

0801375001 8A Tomato-babyfood 0.203000 1.000 1.000 

0801376000 8A Tomato, paste 1.500000 1.000 1.000 

0801376001 8A Tomato, paste-babyfood 1.500000 1.000 1.000 

0801377000 8A Tomato, puree 0.203000 1.000 1.000 

0801377001 8A Tomato, puree-babyfood 0.203000 1.000 1.000 

0801378000 8A Tomato, dried 0.203000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 0.203000 14.300 1.000 

0801379000 8A Tomato, juice 0.203000 1.500 1.000 

0801380000 8A Tomato, Tree 0.203000 1.000 1.000 

0802148000 8BC Eggplant 0.214000 1.000 1.000 
Fluoxastrobin

PC Code: 028869 Dietary Exposure and Risk Assessment DP Number: 409517

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0802234000 8BC Okra 0.214000 1.000 1.000 

0802270000 8B Pepper, bell 0.214000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 0.214000 1.000 1.000 

0802271000 8B Pepper, bell, dried 0.214000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 0.214000 1.000 1.000 

0802272000 8BC Pepper, nonbell 0.214000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 0.214000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 0.214000 1.000 1.000 

0901075000 9A Cantaloupe 0.282000 1.000 1.000 

0901187000 9A Honeydew melon 0.282000 1.000 1.000 

0901399000 9A Watermelon 0.282000 1.000 1.000 

0901400000 9A Watermelon, juice 0.282000 1.000 1.000 

0902021000 9B Balsam pear 0.090000 1.000 1.000 

0902088000 9B Chayote, fruit 0.080000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.090000 1.000 1.000 

0902135000 9B Cucumber 0.090000 1.000 1.000 

0902308000 9B Pumpkin 0.080000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.080000 1.000 1.000 

0902356000 9B Squash, summer 0.080000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.080000 1.000 1.000 

0902357000 9B Squash, winter 0.080000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.080000 1.000 1.000 

1100173500 11 Goji berry 0.203000 1.000 1.000 

1302057000 13B Blueberry 0.560000 1.000 1.000 

1302057001 13B Blueberry-babyfood 0.560000 1.000 1.000 

1307130000 13G Cranberry 0.560000 1.000 1.000 

1307130001 13G Cranberry-babyfood 0.560000 1.000 1.000 

1307131000 13G Cranberry, dried 0.560000 1.000 1.000 

1307132000 13G Cranberry, juice 0.560000 1.100 1.000 

1307132001 13G Cranberry, juice-babyfood 0.560000 1.100 1.000 

1307359000 13G Strawberry 0.560000 1.000 1.000 

1307359001 13G Strawberry-babyfood 0.560000 1.000 1.000 

1307360000 13G Strawberry, juice 0.560000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 0.560000 1.000 1.000 

1500120000 15 Corn, field, flour 0.020000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.020000 1.000 1.000 

1500121000 15 Corn, field, meal 0.020000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.020000 1.000 1.000 

1500122000 15 Corn, field, bran 0.020000 1.000 1.000 

1500123000 15 Corn, field, starch 0.020000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.020000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.020000 1.500 1.000 

1500124001 15 Corn, field, syrup-babyfood 0.020000 1.500 1.000 

1500125000 15 Corn, field, oil 0.020000 1.000 1.000 

1500125001 15 Corn, field, oil-babyfood 0.020000 1.000 1.000 

1500127000 15 Corn, sweet 0.010000 1.000 1.000 DP#364

 Full comment: DP#364445

1500127001 15 Corn, sweet-babyfood 0.010000 1.000 1.000 

1500323000 15 Rice, white 1.177000 1.000 1.000 DP# 39

 Full comment: DP# 392986

1500323001 15 Rice, white-babyfood 1.177000 1.000 1.000 DP# 39

 Full comment: DP# 392986

1500324000 15 Rice, brown 1.177000 1.000 1.000 DP# 39

 Full comment: DP# 392986

1500324001 15 Rice, brown-babyfood 1.177000 1.000 1.000 DP# 39

 Full comment: DP# 392986

1500325000 15 Rice, flour 1.177000 1.000 1.000 DP# 39

 Full comment: DP# 392986

1500325001 15 Rice, flour-babyfood 1.177000 1.000 1.000 DP# 39

 Full comment: DP# 392986

1500326000 15 Rice, bran 1.177000 1.000 1.000 DP# 39

 Full comment: DP# 392986

1500326001 15 Rice, bran-babyfood 1.177000 1.000 1.000 DP# 39

 Full comment: DP# 392986

1500344000 15 Sorghum, grain 1.500000 1.000 1.000 

1500345000 15 Sorghum, syrup 1.500000 1.000 1.000 
Fluoxastrobin

PC Code: 028869 Dietary Exposure and Risk Assessment DP Number: 409517

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1500401000 15 Wheat, grain 0.150000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.150000 1.000 1.000 

1500402000 15 Wheat, flour 0.150000 1.000 1.000 

1500402001 15 Wheat, flour-babyfood 0.150000 1.000 1.000 

1500403000 15 Wheat, germ 0.150000 1.000 1.000 

1500404000 15 Wheat, bran 0.150000 1.000 1.000 

1500405000 15 Wild rice 1.177000 1.000 1.000 

3100044000 31 Beef, meat 0.050000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.050000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.050000 1.920 1.000 

3100046000 31 Beef, meat byproducts 0.200000 1.000 1.000 DP#364

 Full comment: DP#364445

3100046001 31 Beef, meat byproducts-babyfood 0.200000 1.000 1.000 

3100047000 31 Beef, fat 0.100000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.100000 1.000 1.000 

3100048000 31 Beef, kidney 0.200000 1.000 1.000 DP#364

 Full comment: DP#364445

3100049000 31 Beef, liver 0.200000 1.000 1.000 DP#364

 Full comment: DP#364445

3100049001 31 Beef, liver-babyfood 0.200000 1.000 1.000 

3200169000 32 Goat, meat 0.050000 1.000 1.000 

3200170000 32 Goat, meat byproducts 0.200000 1.000 1.000 DP#364

 Full comment: DP#364445

3200171000 32 Goat, fat 0.100000 1.000 1.000 

3200172000 32 Goat, kidney 0.200000 1.000 1.000 DP#364

 Full comment: DP#364445

3200173000 32 Goat, liver 0.200000 1.000 1.000 DP#364

 Full comment: DP#364445

3300189000 33 Horse, meat 0.050000 1.000 1.000 

3400291000 34 Pork, skin 0.060000 1.000 1.000 DP#392

 Full comment: DP#392986

3400292000 34 Pork, meat byproducts 0.060000 1.000 1.000 DP#392

 Full comment: DP#392986

3400292001 34 Pork, meat byproducts-babyfood 0.060000 1.000 1.000 DP#392

 Full comment: DP#392986

3400293000 34 Pork, fat 0.030000 1.000 1.000 DP#392

 Full comment: DP#392986

3400293001 34 Pork, fat-babyfood 0.030000 1.000 1.000 DP#392

 Full comment: DP#392986

3400294000 34 Pork, kidney 0.060000 1.000 1.000 DP#392

 Full comment: DP#392986

3400295000 34 Pork, liver 0.060000 1.000 1.000 DP#392

 Full comment: DP#392986

3500339000 35 Sheep, meat 0.050000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.050000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 0.200000 1.000 1.000 DP#364

 Full comment: DP#364445

3500341000 35 Sheep, fat 0.100000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.100000 1.000 1.000 

3500342000 35 Sheep, kidney 0.200000 1.000 1.000 DP#364

 Full comment: DP#364445

3500343000 35 Sheep, liver 0.200000 1.000 1.000 DP#364

 Full comment: DP#364445

3600222000 36 Milk, fat 0.750000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.750000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.030000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.030000 1.000 1.000 

3600224000 36 Milk, water 0.030000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.030000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.030000 1.000 1.000 

4000094000 40 Chicken, liver 0.060000 1.000 1.000 DP#392

 Full comment: DP#392986

5000383000 50 Turkey, liver 0.060000 1.000 1.000 

5000383001 50 Turkey, liver-babyfood 0.060000 1.000 1.000 

6000302000 60 Poultry, other, liver 0.060000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.137000 1.000 1.000 
Fluoxastrobin

PC Code: 028869 Dietary Exposure and Risk Assessment DP Number: 409517

___________________________________________________________________________________ 

 Page 12 of 13

8602000000 86B Water, indirect, all sources 0.137000 1.000 1.000 

9500263000 O Peanut 0.020000 1.000 1.000 DP#364

 Full comment: DP#364445

9500264000 O Peanut, butter 0.020000 1.890 1.000 DP#364

 Full comment: DP#364445

9500265000 O Peanut, oil 0.060000 1.000 1.000 DP#364

 Full comment: DP#364445
Fluoxastrobin

PC Code: 028869 Dietary Exposure and Risk Assessment DP Number: 409517

___________________________________________________________________________________ 

 Page 13 of 13

Attachment 2. Fluoxastrobin Chronic Dietary Analysis Results - Food & Water

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for FLUOXASTROBIN NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\MNEGUSSI\My Documents\DEEM Version 

3.16\Fluoxastrobin\MelonSorghum\FLUOXASTROBIN_TOL+WATER_Jan2013.R08

 Adjustment factor #2 NOT used.

Analysis Date 02-27-2013/12:02:10 Residue file dated: 02-27-2013/12:01:16

Reference dose (RfD, Chronic) = .015 mg/kg bw/day

COMMENT 1: New Use Melon and Sorghum; new EDWC 137 ppb Refinement-Rice, subgroup 4B, 

9A, 9B, 13-07G, group 8,

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.004529 30.2%

Hispanic 0.004667 31.1%

Non-Hisp-White 0.004547 30.3%

Non-Hisp-Black 0.003794 25.3%

Non-Hisp-Other 0.005687 37.9%

Nursing Infants 0.003969 26.5%

Non-Nursing Infants 0.012528 83.5%

Female 13+ PREG 0.004122 27.5%

Children 1-6 0.008050 53.7%

Children 7-12 0.004796 32.0%

Male 13-19 0.003476 23.2%

Female 13-19/NP 0.003554 23.7%

Male 20+ 0.004039 26.9%

Female 20+/NP 0.004214 28.1%

Seniors 55+ 0.003920 26.1%

All Infants 0.009886 65.9%

Female 13-50 0.004116 27.4%

Children 1-2 0.009516 63.4%

Children 3-5 0.007496 50.0%

Children 6-12 0.005052 33.7%

Youth 13-19 0.003514 23.4%

Adults 20-49 0.004226 28.2%

Adults 50-99 0.003999 26.7%

Female 13-49 0.004118 27.5%