Report 6010 National Toxicology Program 09/18/2015 10:46

Division of Toxicology Research and Testing

Management Status Report

Produced from NTP Chemtrack System

Public Distribution

Chemicals studied by the National Toxicology Program are selected mainly on the basis of

human exposure, production levels, chemical structure, and available toxicologic data. Selection

of a chemical for a study does not imply that the chemical is hazardous or a potential carcinogen

in laboratory animals; likewise, a chemical not selected for toxicologic study by the Program

should not be taken to mean that the chemical is not potentially hazardous or potentially

carcinogenic in laboratory rodents. Compounds are listed by a common or generic name; if this is

not available, the chemical name is used. For additional information, send requests to: Central

Data Management (CDM) (TELEPHONE: 919-541-3419; FAX: (301) 480-3210; Mail Drop K2-05, NIEHS, P.

O. BOX 12233, Research Triangle Park, NC USA 27709; EMAIL: CDM@NIEHS.NIH.GOV) .

The abstracts for all published long-term NTP technical reports are available in Volume

101, Supplement 1 of ENVIRONMENTAL HEALTH PERSPECTIVES (EHP) (1993). Abstracts as well as full

versions of NTP toxicology and carcinogenesis studies and short-term toxicity studies are

available in electronic format on the National Toxicology Program World Wide Web (WWW) site.

Viewing this information requires access to the Internet and a software client such as Netscape

or Internet Explorer. The World Wide Web server is located at NIEHS; the link to access the NTP

World Wide Web Homepage is http://ntp.niehs.nih.gov/. The link to NTP testing information and

study results, including abstracts, is /go/test

Printed copies of many Technical Reports on NTP toxicology and carcinogenesis studies

and short-term toxicity studies are available from Central Data Management (CDM) (TELEPHONE:

919-541-3419; FAX: (301) 480-3210; Mail Drop K2-05, NIEHS, P. O. BOX 12233, Research Triangle

Park, NC USA 27709; EMAIL: CDM@NIEHS.NIH.GOV) .

If you have further questions about electronic access or to request a copy of EHP, VOL. 101,

contact Central Data Management (CDM) (TELEPHONE: 919-541-3419; FAX: (301) 480-3210; Mail Drop

K2-05, NIEHS, P. O. BOX 12233, Research Triangle Park, NC USA 27709; EMAIL: CDM@NIEHS.NIH.GOV) .

Contents Number of Chemicals

Ref No. 1 Chemicals Selected for General Toxicology Study by the NTP............................................ 0

Ref No. 2 Chemicals with Project Leader Assigned/Study in Design............................................... 29

Ref No. 3 Chemicals Approved for Toxicology/Carcinogenesis Study................................................ 18

Ref No. 4 Chemicals Assigned to Laboratory for Toxicology/Carcinogenesis Study.................................. 29

Ref No. 5 Short-Term Exposure Studies in Progress...............................................................23

Ref No. 6 Short-Term Studies Completed: In Review for Further Evaluation....................................... 10

Ref No. 7 Long-Term Exposure Studies in Progress.................................................................3

Ref No. 8 Long-Term Exposure Studies: Laboratory Study Report in Preparation....................................20

Ref No. 9 (Note: Reference 9 Combined with Reference 10)........................................................ 0

Ref No. 10 Long-Term Exposure Studies: Pathology Quality Assessment in Progress..................................11

Ref No. 11 Long-Term Exposure Studies: Pathology Working Group Scheduled..........................................0

Ref No. 12 Short-Term Exposure Studies Scheduled for Peer Review................................................. 9

Ref No. 13 Long-Term Exposure Studies Scheduled for Peer Review.................................................. 4

Ref No. 14 Post Peer Review Technical Reports in Progress....................................................... 17

Ref No. 15 Galley or Camera Copy Technical Reports in Progress................................................... 0

Ref No. 16 Printed Long-Term and Short-Term Study Reports...................................................... 826

Ref No. 17 Long-Term Exposure Studies for Which Technical Reports Were Not Prepared..............................60

Appendix Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared............................334

Long-term studies = more than 1 year

Short-term studies = 1 year or less
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Abbreviations used in this report:

CODE Route of Administration CODE Route of Administration

AQUAT Aquatic IV Intravenous

CAPS Per Os (Capsule) IVAG Intravaginal

DERMAL Dermal IVOR IV Injection and Oral

FEED Dosed-Feed MICRO Microencapsulation in Feed

GAV Gavage MULTI Multiple Routes

GAV/

WATER

Gavage & Dosed-Water N/A Not Applicable

GV/WB Gavage, Whole Body Exposure OTHER Other

IC/IJ IC Injection SC&GV Subcutaneous Injection and Gavage

ID/CN Intraductal Cannulation SC/IJ Subcutaneous Injection

IM Intramuscular SP Topical Application

INHAL Inhalation UD Not Currently Entered

IP/IJ Intraperitoneal Injection UTERO In Utero

IP/OT IP Inj/Orotracheal WATER Dosed-Water

IT Intratracheal WB Whole Body Exposure

Note: Dermal, skin application and skin paint are synonymous. Different terms were used at different times.

CODE Primary Use Category CODE Primary Use Category

ADHS Adhesives, Glues, and Tape METL Metals or Metal Products

CMOT Chemotherapeutic Agents MINL Minerals and Natural Fibers

COMT Contaminates and/or Impurities MLTR Military or Policing Purposes

COSM Cosmetics, Perfumes, Fragrances, Hair Preparations,

Skin Lotions

N/S Naturally Occurring and Synthetic Substances

DIET Dietary/Herbal Supplement NANO Nanoscale materials (substances where at least one

critical dimension < 100 nm)

DTRG Detergents and Cleansers NATL Naturally Occurring Substances

DYE Dyes, Inks, and Pigments NSUL Insulation or Insulation Products

ELEC Electrical and/or Dielectric Systems or Products OCCH Occupational Hazards

ENVH Environmental (Air/Water) Pollutants PAPR Paper or Paper Products

FDPK Food-packaging Products PEST Pesticides

FEED Animal Feed or Feed Products PHAR Pharmaceuticals or Intermediates

FERT Fertilizers PHOT Photography or Related Purposes

FLAM Flame Retardants PLAS Plastics

FOOD Food, Beverages, or Additives PNT Paint Ingredient

FUEL Fuel or Oil Products REAG Laboratory Reagent

FUME Fumigants RUBR Rubber Chemical

FUNG Fungicides SOLV Vehicles and Solvents

GERM Germicides, Disinfectants, Antiseptics SYN Synthetic

GLAS Glass, Ceramic and/or Pottery Products TBCO Tobacco and Tobacco Products

HERB Herbicides TEXL Manufacture of Textiles

IND Industrial Uses WATR Water and/or Sewage Treatment

INTR Chemical Intermediate or Catalyst WOOD Wood Industry

LABC Unspecified Chemical Uses Not Fitting Into SOLV, INTR,

or REAG Categories

CODE Species: Strain CODE Species: Strain

C Chicks H Hamsters

D Dog M Mice

DL Drosophila MO Monkey

F Fish R Rats

FR Frog RA Rabbit

GP Guinea Pigs RM Rats/Mice

NA Chicks:Not Available * MK Mice:CB6F1-Tg(HRAS)2Jic [(BALB/cByJTac x C57BL/6JTac)-

Tg(HRAS)2Jic F1

NA Dog:Not Available * ML Mice:Tg.Lac1/C57BL/6 (Big Blue)

O3 Dog:Beagles MM Mice:BALB/cByJ

NA Drosophila:Not Available * MN Mice:Tg.AC (FVB/N) Homozygous
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CODE Species: Strain CODE Species: Strain

F1 Fish:Medaka (Oryzias Latipes) MO Mice:CB6F1

F2 Fish:Guppy (Poecilia Reticulata) * MP Mice:C57BL/6-APC+/APC-1638N (Tg:APC)

F3 Fish:Zebra (Danio rerio) * MQ Mice:P16(Ink4a)/(+/-) (C57BL/6)

NA Fish:Not Available MR Mice:129S1/SvImJ

NA Frog:Not Available * MS Mice:P53 +/- (FVB/N)

NA Guinea Pigs:Not Available MT Mice:SKH-1 Hairless

O6 Guinea Pigs:Hartley * MU Mice:TRAMP (C57BL/6 PB-TAG TRANSGENE)

H1 Hamsters:Syrian Golden MV Mice:B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)

NA Hamsters:Not Available MW Mice:BALB/c

129B6TRP53 Mice:Female 129S1.SvlmJ crossed to B6.129-

Trp53<tm1Brd> males homozygous for the Trp53 null

allele

* MX Mice:AM3 (C57BL/6)

60 Mice:NOD. B10Sn-H2(b)/J MY Mice:CD-1 Reg.[Crl:CD1(ICR)]

61 Mice:NZO/HiLtJ MZ Mice:C57BL/6J (Jackson)

62 Mice:PWK/PhJ NA Mice:Not Available

63 Mice:B6C3F1 (Jackson) RB6TRP53Mice:Female BTBR.Tj (R) crossed to B6.129-

Trp53<tm1Brd> males homozygous for the Trp53 null

allele

AB6TRP53Mice:Female A/J crossed to B6.129-Trp53<tm1Brd> males

homozygous for the Trp53 null allele

NA Monkey:Not Available

B6129 Mice:B6.129-Trp53<TM1BRD> RH Monkey:Rhesus

C3B6 Mice:C3B6.129F1-Trp53<TM1BRD> 44 Rats:Sprague Dawley (NCTR)

C3B6TRP53Mice:Female C3H/HeJ crossed to B6.129- Trp53<tm1Brd>

males homozygous for the Trp53 null allele

F344 Rats:Fischer 344

C6N Mice:C57BL/6N HSD Rats:Harlan Sprague-Dawley

CB6TRP53Mice:Female Balb/c (C) crossed to B6.129-

Trp53<tm1Brd> males homozygous for the Trp53 null

allele

HSDD Rats:Harlan Sprague Dawley (Dublin Facility)

D2B6TRP53Mice:Female DBA2/J (D2) crossed to B6.129-

Trp53<tm1Brd> males homozygous for the Trp53 null

allele

HSDI Rats:Harlan Sprague Dawley (Indianapolis Facility)

DOJ Mice:Diversity Outbred (Jackson) * ML Rats:Tg.Lac1/C57BL/6 (Big Blue)

M0 Mice:Skh-1 Hairless (NCTR) NA Rats:Not Available

M1 Mice:C57BL/6 R1 Rats:Osborne Mendel

M11 Mice:CAST/EiJ (M. m. castaneus) R10 Rats:F344/N Charles River

M14 Mice:WSB/EiJ (M. m. domesticus) R2 Rats:F344/N

M15 Mice:C3H/HeJ R3 Rats:ACI

M2 Mice:C3H R4 Rats:August

M3 Mice:B6C3F1 R5 Rats:Long-Evans

M4 Mice:Swiss R6 Rats:Marshall

M5 Mice:Swiss CD-1 R7 Rats:Sherman

M6 Mice:Swiss Webster R8 Rats:Sprague Dawley

M7 Mice:Sencar R9 Rats:Wistar

* M8 Mice:MMTV/RAS (Tg.SH) RA Rats:CD

* M9 Mice:MMTV/MYC (Tg.M) RB Rats:NCI Black Reiter (NBR)

* MA Mice:MMTV/NEU (Tg.Nk) RC Rats:F344 (NCTR)

MB Mice:NIH Swiss RD Rats:F344/NTac

* MC Mice:PIM RE Rats:Wistar Han

MCBA Mice:CBA/ Ca Jackson ZL Rats:Zucker - Lean (HsdHlr:ZUCKER-Lepr+)

* MD Mice:P53 +/- (C57BL/6) ZLC Rats:Zucker - Lean (Charles River)

* ME Mice:Tg.AC (FVB/N) Hemizygous ZO Rats:Zucker - Obese (HsdHlr:ZUCKER-Leprfa)

MF Mice:A/J ZOC Rats:Zucker - Obese (Charles River)

MG Mice:B6.SJL-Ptprc[a] Pepc[b]/BoyJ NA Rabbit:Not Available

* MH Mice:Tg/RASH2/CB6F1 NA Rats/Mice:Not Available

MI Mice:FVB/N R2 Rats/Mice:F344/N

* MJ Mice:C3B6F1-+/TRP53<TM1BRD> (NCTR)

* Transgenic Mouse Model
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CAR Carcinogenicity:

The National Toxicology Program describes the results of individual experiments on a chemical agent and notes the

strength of evidence for conclusions regarding each study. Negative results, in which the study animals do not have

a greater incidence of neoplasia than control animals, do not necessarily mean that a chemical is not a carcinogen,

inasmuch as the experiments are conducted under a limited set of conditions. Positive results demonstrate that a

chemical is carcinogenic for laboratory animals under the conditions of the study and indicate that exposure to the

chemical has the potential for hazard to humans. Five categories of evidence of carcinogenic activity are used in

the Technical Report series to summarize the strength of the evidence observed in each experiment: two categories for

positive results ("Clear Evidence" and "Some Evidence"); one category for uncertain findings ("Equivocal Evidence");

one category for no observable effects ("No Evidence"); and one category for experiments that because of major flaws

cannot be evaluated ("Inadequate Study"). These categories of interpretative conclusions were first adopted in June

1983 and then revised in March 1986 for use in the Technical Reports series to incorporate more specifically the

concept of actual weight of evidence of carcinogenic activity. For each separate experiment (male rats, female rats,

male mice, female mice), one of the following quintet is selected to describe the findings. The categories refer to

the strength of the experimental evidence and not to either potency or mechanism.

CE Clear Evidence of Carcinogenic Activity is demonstrated by studies that are interpreted as showing a

dose-related (i) increase of malignant neoplasms, (ii) increase of a combination of malignant and benign

neoplasms, or (iii) marked increase of benign neoplasms if there is an indication from this or other studies of

the ability of such tumors to progress to malignancy.

SE Some Evidence of Carcinogenic Activity is demonstrated by studies that are interpreted as showing a

chemicallyrelated increased incidence of neoplasms (malignant, benign, or combined) in which the strength of

the response is less than that required for clear evidence.

EE Equivocal Evidence of Carcinogenic Activity is demonstrated by studies that are interpreted as showing a

marginal increase of neoplasms that may be chemically related.

NE No Evidence of Carcinogenic Activity is demonstrated by studies that are interpreted as showing no chemically

related increases in malignant or benign neoplasms.

IS Inadequate Study of Carcinogenic Activity is demonstrated by studies that because of major qualitative

or quantitative limitations cannot be interpreted as valid for showing either the presence or absence of

carcinogenic activity.

When a conclusion statement for a particular experiment is selected, consideration must be given to key factors

that would extend the actual boundary of an individual category of evidence. This should allow for incorporation of

scientific experience and current understanding of long-term carcinogenesis studies in laboratory animals, especially

for those evaluations that may be on the borderline between two adjacent levels. These considerations should include:

- The adequacy of the experimental design and conduct;

- Occurrence of common versus uncommon neoplasia;

- Progression (or lack thereof) from benign to malignant neoplasia as well as from preneoplastic to neoplastic

lesions;

- Some benign neoplasms have the capacity to regress but others (of the same morphologic type) progress. At

present, it is impossible to identify the difference. Therefore, where progression is known to be a possibility,

the most prudent course is to assume that benign neoplasms of those types have the potential to become malignant;

- Combining benign and malignant tumor incidences known or thought to represent stages of progression in the same

organ or tissue;

- Latency in tumor induction;

- Multiplicity in site-specific neoplasia;

- Metastases;

- Supporting information from proliferative lesions (hyperplasia) in the same site of neoplasia or in other

experiments (same lesion in another sex or species);

- The presence or absence of dose relationships;

- The statistical significance of the observed tumor increase;

- The concurrent control tumor incidence as well as the historical control rate and variability for a specific

neoplasm;

- Survival-adjusted analyses and false positive or false negative concerns;

- Structure-activity correlations; and

- In some cases, genetic toxicology.

Earlier designations include:

P Positive E Equivocal N Negative I Inadequate
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@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Abrasive Blasting Agents:

Blasting Sand

BLASTINGSAND 34 14

Abrasive blasting agents (coal

slag)

COALSLAG 49 *

Abrasive blasting agents (crushed

glass)

CRUSHEDGLASS 49 *

Abrasive blasting agents (garnet) GARNET 49 *

Abrasive Blasting Agents:

Specular Hematite

HEMATITESPEC 34 14

@ Acesulfame Potassium Transgenic

Model Evaluation II

(Listed As: Transgenic Model

Evaluation II (Acesulfame

Potassium))

55589-62-3 35 16

Acetaminophen

(4-hydroxyacetanilide)

103-90-2 38 16

Acetaminophen

(4-hydroxyacetanilide)

103-90-2 49 *

Acetochlor 34256-82-1 49 *

Acetohexamide 968-81-0 38 16

Acetoin 513-86-0 34 14

Acetone 67-64-1 35 16

Acetonitrile 75-05-8 49 *

Acetonitrile 75-05-8 38 16

Acrolein 107-02-8 35 16

Acronycine 7008-42-6 38 16

Acrylamide 79-06-1 38 16

Acrylamide 79-06-1 50 *

@ Acryl Brilliant Green

(Listed As: Malachite green)

569-64-2 44 16

@ Acryl Brilliant Green

(Listed As: Malachite green)

569-64-2 37 16

Acrylonitrile 107-13-1 38 16

Actinomycin D 50-76-0 48 17

Adeno-associated viral vector

(hEPO)

AAVIRVECEPO 50 *

Adenoviral vector (hGH) ADNVIRVECHGH 50 *

Adenoviral Vector (AdhAQP1) ADNVIRVECAQP 50 *

Aflatoxin B1 (TGMX) 1162-65-8 32 5

Agar 9002-18-0 38 16

Agaritine 2757-90-6 48 17

Aging Cohort Study: 129/SvlmJ

mouse

MOUSEPHENO1 33 8

Aging Cohort Study: B6C3F1J mouse MOUSEPHENO6 33 8

Aging Cohort Study: C3H/HeJ mouse MOUSEPHENO3 33 8

Aging Cohort Study: C57/BL/6J

mouse

MOUSEPHENO4 33 8

Aging Cohort Study: CAST/EiJ

mouse

MOUSEPHENO5 33 8

Aging Cohort Study: NZO/HiLtJ

mouse

MOUSEPHENO10 33 8

Aging Cohort Study: PWK/PhJ mouse MOUSEPHENO8 33 8

Aging Cohort Study: WSB/EIJ mouse MOUSEPHENO9 33 8

Aging Cohort Study: A/J mouse MOUSEPHENO2 33 8

Aging Cohort Study: NOD.

B10Sn-H2(b)/J

MOUSEPHENO7 33 8

@ Aizen Malachite Green

(Listed As: Malachite green)

569-64-2 44 16

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ Aizen Malachite Green

(Listed As: Malachite green)

569-64-2 37 16

Aldicarb 116-06-3 38 16

Aldrin 309-00-2 38 16

Allyl acetate 591-87-7 35 16

Allyl alcohol 107-18-6 35 16

Allyl bromide 106-95-6 35 16

Allyl bromide 106-95-6 50 *

Allyl bromide 106-95-6 35 16

Allyl chloride 107-05-1 38 16

Allyl glycidyl ether 106-92-3 38 16

Allyl isothiocyanate 57-06-7 39 16

Allyl isovalerate 2835-39-4 39 16

Aloe-emodin 481-72-1 39 16

Aloe phototoxicity studies ALOEPHOTOTOX 39 16

Aloe vera charcoal filtered whole

leaf extract

ALOEVFILTER 39 16

Aloe vera gel 8001-97-6 39 16

Aloe vera whole leaf extract

(native)

ALOEVLEAFEXT 39 16

Aloe vera whole leaf extract

(native)

ALOEVLEAFEXT 39 16

alpha/beta Hydroxy acids

(glycolic acid, salicylic acid)

HYDROXGLYSAL 39 16

alpha-Pinene 80-56-8 34 12

alpha-Pinene 80-56-8 33 7

Ametryn 834-12-8 50 *

9-Aminoacridine hydrochloride 134-50-9 50 *

9-Aminoacridine hydrochloride 134-50-9 50 *

2-Aminoanthraquinone 117-79-3 39 16

5-Amino-o-cresol 2835-95-2 34 14

1-Amino-2,4-dibromoanthraquinone 81-49-2 39 16

3-Amino-4-ethoxyacetanilide 17026-81-2 39 16

3-Amino-9-ethylcarbazole 132-32-1 48 17

3-Amino-9-ethylcarbazole HCl 6109-97-3 39 16

1-Amino-2-methylanthraquinone 82-28-0 39 16

2-Amino-4-nitrophenol 99-57-0 39 16

2-Amino-5-nitrophenol 121-88-0 39 16

4-Amino-2-nitrophenol 119-34-6 39 16

2-Amino-5-nitrothiazole 121-66-4 39 16

2-(4-Aminophenyl)-6-methyl-7-

benzothiazole sulfonic acid

130-17-6 50 *

3-Aminopyridine 462-08-8 50 *

2-Aminopyridine 504-29-0 50 *

4-Aminopyridine 504-24-5 50 *

Comparison study of

Aminopyridines/Troponin levels

AMINOPYRCOMP 50 *

11-Aminoundecanoic acid 2432-99-7 39 16

DL-amphetamine sulfate 60-13-9 39 16

Ampicillin trihydrate 7177-48-2 39 16

Amsacrine 51264-14-3 48 17

@ AN

(Listed As: Acrylonitrile)

107-13-1 38 16

Androstenedione 63-05-8 50 *

Androstenedione 63-05-8 50 *

Androstenedione 63-05-8 39 16

Anilazine 101-05-3 39 16
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@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ Aniline Green

(Listed As: Malachite green)

569-64-2 44 16

@ Aniline Green

(Listed As: Malachite green)

569-64-2 37 16

Aniline hydrochloride 142-04-1 39 16

@ p-Anisidine hydrochloride

Transgenic model evaluation

(Listed As: Transgenic model

evaluation (p-Anisidine HCl))

20265-97-8 53 *

o-Anisidine hydrochloride 134-29-2 39 16

p-Anisidine hydrochloride 20265-97-8 39 16

o-Anthranilic acid 118-92-3 39 16

Anthraquinone 84-65-1 39 16

Antimony potassium tartrate 28300-74-5 16

Antimony Trioxide 1309-64-4 34 13

Arsenic antioxidant mixture ANTIOXCOMBO2 50 *

Arsenic antioxidant mixture ANTIOXCOMBO2 50 *

Antioxidant model (TRAMP) -

N-acetylcysteine

616-91-1 50 *

Antioxidant model (TRAMP) -

Epigallocatechin gallate

989-51-5 50 *

Antioxidant model (TRAMP) - NAO

(spinach extract)

NAOSPINEXTR 50 *

L-Arginine Glutamate 4320-30-3 48 17

Aroclor 1254 11097-69-1 39 16

@ Arotonoid (Retinoid project 6)

(Listed As: Retinoid project 6

(Arotinoid))

125533-88-2 53 *

Arsine 7784-42-1 50 *

Asbestos, amosite 12172-73-5 31 4

Asbestos, amosite 12172-73-5 39 16

Asbestos, amosite 12172-73-5 39 16

Asbestos, amosite + Dimethyl

hydrazine

12172-73-5 39 16

Asbestos, chrysotile(IR) 12001-29-5 39 16

Asbestos, chrysotile(IR) 12001-29-5 39 16

Asbestos, chrysotile(IR) 12001-29-5 39 16

Asbestos, chrysotile(IR) +

Dimethyl hydrazine

12001-29-5 39 16

Asbestos, chrysotile(IR) +

Dimethyl hydrazine

12001-29-5 39 16

Asbestos, chrysotile(SR) 12001-29-5 39 16

Asbestos, chrysotile(SR) 12001-29-5 39 16

Asbestos, crocidolite 12001-28-4 39 16

L-Ascorbic acid 50-81-7 39 16

@ Aspartame (transgenic model

evaluation II)

(Listed As: Transgenic model

evaluation II (Aspartame))

22839-47-0 35 16

@ Aspartame (transgenic model

evaluation II)

(Listed As: Transgenic model

evaluation II (Aspartame))

22839-47-0 35 16

Aspergillus versicolor mold ASPERGILLUSV 31 4

Aspergillus fumigatus mold ASPERGILLUS 31 3

Aspirin, phenacetin, and caffeine 8003-03-0 39 16

5-Azacytidine 320-67-2 39 16

Azathioprine 446-86-6 48 17

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 39 16

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 39 16

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 39 16

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 39 16

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 39 16

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 39 16

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 39 16

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 39 16

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 39 16

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 39 16

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 39 16

3'-Azido-3'-deoxythymidine and

2',3'-Dideoxycytidine

AZTDDCCOMB 50 *

@ 3'-Azido-3'-deoxythymidine/2',3'-

Dideoxycytidine (AIDS initiative)

(Listed As: 3'-Azido-3'-

deoxythymidine and 2',3'-

Dideoxycytidine)

AZTDDCCOMB 50 *

3'-Azido-3'-deoxythymidine

and 2',3'-Dideoxyinosine (AIDS

initiative)

AZTDDICOMB 50 *

Azinphosmethyl 86-50-0 39 16

Azobenzene 103-33-3 39 16

Azodicarbonamide 123-77-3 50 *

AZT+3TC+NVP combination AZT3TCCOMBO 39 16

@ AZT (AIDS initiative)

(Listed As: 3'-Azido-3'-

deoxythymidine (AIDS))

30516-87-1 39 16

@ AZT (AIDS initiative)

(Listed As: 3'-Azido-3'-

deoxythymidine (AIDS))

30516-87-1 39 16

@ AZT (AIDS initiative)

(Listed As: 3'-Azido-3'-

deoxythymidine (AIDS))

30516-87-1 39 16

@ AZT (AIDS initiative)

(Listed As: 3'-Azido-3'-

deoxythymidine (AIDS))

30516-87-1 39 16

@ AZT (AIDS initiative)

(Listed As: 3'-Azido-3'-

deoxythymidine (AIDS))

30516-87-1 39 16

@ AZT (AIDS initiative)

(Listed As: 3'-Azido-3'-

deoxythymidine (AIDS))

30516-87-1 39 16

@ AZT (AIDS initiative)

(Listed As: 3'-Azido-3'-

deoxythymidine (AIDS))

30516-87-1 39 16

@ AZT (AIDS initiative)

(Listed As: 3'-Azido-3'-

deoxythymidine (AIDS))

30516-87-1 39 16

@ AZT (AIDS initiative)

(Listed As: 3'-Azido-3'-

deoxythymidine (AIDS))

30516-87-1 39 16

@ AZT (AIDS initiative)

(Listed As: 3'-Azido-3'-

deoxythymidine (AIDS))

30516-87-1 39 16

@ AZT (AIDS initiative)

(Listed As: 3'-Azido-3'-

deoxythymidine (AIDS))

30516-87-1 39 16

@ AZT + DDI (AIDS initiative)

(Listed As: 3'-Azido-3'-

deoxythymidine and 2',3'-

Dideoxyinosine (AIDS

initiative))

AZTDDICOMB 50 *

AZT/Drug Combinations

Transplacental/Neonatal Study

AIDSDRUGSNEO 33 8
Last Update: 09/18/2015 10:46 Management Status Report Page 8

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

AZT/Drug Combinations

Transplacental Carcinogenesis

Study

AIDSTHERAPEU 39 16

AZT + Isoniazid (AIDS Initiative) AZTISONIAZID 35 16

AZT + Methadone HCl (AIDS) AZTMETHCOMB 50 *

AZT + Nitazoxanide (AIDS

Initiative)

AZT+NITAZOX 50 *

AZT + Pyrazinamide combination

(AIDS Initiative)

AZTZINAMIDE 35 16

AZT + Rifampin (AIDS Initiative) AZTRIFAMPIN 35 16

AZT + TMP/SMX (mixture)

combination

AZTTMPSMX 50 *

AZT + TMP/SMX (mixture)

combination

AZTTMPSMX 50 *

AZT transplacental carcinogenesis

study

30516-87-1 39 16

Barium chloride dihydrate 10326-27-9 38 16

Barium chloride dihydrate 10326-27-9 39 16

@ BCNU

(Listed As: 1,3-

bis(Chloroethyl)-1-

nitrosourea)

154-93-8 48 17

BDE Toxicogenomics Study (TGMX) TGMXBDECLASS 31 2

Benzaldehyde 100-52-7 39 16

@ Benzaldehyde Green

(Listed As: Malachite green)

569-64-2 44 16

@ Benzaldehyde Green

(Listed As: Malachite green)

569-64-2 37 16

Benzene 71-43-2 39 16

@ Benzene (Transgenic model

evaluation II)

(Listed As: Transgenic model

evaluation II (Benzene))

71-43-2 35 16

Benzethonium chloride 121-54-0 38 16

Benzethonium chloride 121-54-0 39 16

Benzidine dihydrochloride 531-85-1 50 *

Benzofuran 271-89-6 39 16

Benzoin 119-53-9 39 16

Benzonitrile 100-47-0 50 *

Benzophenone 119-61-9 35 16

Benzophenone 119-61-9 39 16

p-Benzoquinone dioxime 105-11-3 40 16

1,2,3-Benzotriazole 95-14-7 40 16

Phenolic Benzotriazoles (2-(2HBenzotriazol-2-yl)-4-tertbutylphenol)3147-76-0 31 4

@ Benzoyl peroxide

(Listed As: Init/prom

comparative mouse study (DMBA/

TPA/BPO/MNNG))

INIT/PROM 43 16

@ Benzoyl peroxide

(Listed As: Init/prom

comparative mouse study (DMBA/

TPA/BPO/MNNG))

INIT/PROM 43 16

@ Benzoyl peroxide

(Listed As: Init/prom

comparative mouse study (DMBA/

TPA/BPO/MNNG))

INIT/PROM 43 16

Benzyl acetate 140-11-4 40 16

Benzyl acetate 140-11-4 40 16

Benzyl acetate + glycine

combination study

GLYCINEBENZA 50 *

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Benzyl alcohol 100-51-6 40 16

Benzyl chloride 100-44-7 48 17

o-Benzyl-p-chlorophenol 120-32-1 38 16

o-Benzyl-p-chlorophenol 120-32-1 40 16

o-Benzyl-p-chlorophenol 120-32-1 40 16

Benzyltrimethyl ammonium chloride 56-93-9 35 16

Benzyltrimethyl ammonium chloride 56-93-9 50 *

Benzyltrimethyl ammonium chloride 56-93-9 35 16

@ Binary mixture (Toxic equivalency

factor evaluation)

(Listed As: Toxic equivalency

factor evaluation (Binary

mixture; PCB 126/PCB 153))

TEFBINARYMIX 46 16

2-Biphenylamine hydrochloride 2185-92-4 40 16

2,2-bis(Bromomethyl)-1,3-

propanediol

3296-90-0 50 *

2,2-bis(Bromomethyl)-1,3-

propanediol

3296-90-0 38 16

2,2-bis(Bromomethyl)-1,3-

propanediol

3296-90-0 40 16

1,3-bis(Chloroethyl)-1-

nitrosourea

154-93-8 48 17

bis(Chloromethyl) ether 542-88-1 48 17

bis(2-Chloro-1-methylethyl) ether 108-60-1 40 16

bis(2-Chloro-1-methylethyl) ether 108-60-1 40 16

Bisphenol A 80-05-7 33 8

Bisphenol A 80-05-7 50 *

Bisphenol A 80-05-7 40 16

Bisphenol S 80-09-1 31 4

@ Black 38, C.I. Acid

(Listed As: C.I. Direct Black

38)

1937-37-7 36 16

@ Black Cloud Mine Ore (Colorado)

(Listed As: Lead ores)

LEADORES 51 *

Black Cohosh 84776-26-1 50 *

Black Cohosh 84776-26-1 33 8

Black Cohosh 84776-26-1 50 *

Black Cohosh 84776-26-1 50 *

Black newsprint ink EMTDP-75 35 16

@ Blue 15, C.I. Direct

(Listed As: C.I. Direct Blue

15)

2429-74-5 41 16

@ Blue 218, C.I. Direct

(Listed As: C.I. Direct Blue

218)

28407-37-6 38 16

@ Blue 218, C.I. Direct

(Listed As: C.I. Direct Blue

218)

28407-37-6 41 16

@ Blue 6, C.I. Direct

(Listed As: C.I. Direct Blue

6)

2602-46-2 36 16

@ Blue 6, C.I. Direct

(Listed As: C.I. Direct Blue

6)

2602-46-2 50 *

@ Blue 1, HC

(Listed As: HC Blue 1)

2784-94-3 43 16

@ Blue 2, HC

(Listed As: HC Blue 2)

33229-34-4 43 16

@ BMPC

(Listed As: Ionic Liquid: 1-

Butyl-1-methylpyrrolidinium

Chloride)

479500-35-1 32 5
Last Update: 09/18/2015 10:46 Management Status Report Page 9

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Boric acid 10043-35-3 40 16

@ BPDP

(Listed As: tert-Butylphenyl

Diphenyl Phosphate)

56803-37-3 50 *

@ BPDP

(Listed As: tert-Butylphenyl

Diphenyl Phosphate)

56803-37-3 31 2

Bromobenzene 108-86-1 50 *

Bromobenzene 108-86-1 50 *

@ Bromochloroacetic acid (Water

disinfection byproducts)

(Listed As: Water disinfection

byproducts (Bromochloroacetic

acid))

5589-96-8 47 16

Bromodichloromethane 75-27-4 40 16

@ BromodichloromethaneE (Transgenic

model evaluation)

(Listed As: Transgenic

model evaluation

(Bromodichloromethane))

75-27-4 54 *

@ BromodichloromethaneE (Transgenic

model evaluation)

(Listed As: Transgenic

model evaluation

(Bromodichloromethane))

75-27-4 54 *

@ Bromodichloromethane (Water

disinfection model)

(Listed As: Water disinfection

model (Bromodichloromethane))

75-27-4 35 16

@ Bromodichloromethane (Water

disinfection model)

(Listed As: Water disinfection

model (Bromodichloromethane))

75-27-4 35 16

@ Bromodichloromethane (Water

disinfection model)

(Listed As: Water disinfection

model (Bromodichloromethane))

75-27-4 35 16

@ Bromodichloromethane (Water

disinfection model)

(Listed As: Water disinfection

model (Bromodichloromethane))

75-27-4 35 16

@ Bromodichloromethane (Water

disinfection model)

(Listed As: Water disinfection

model (Bromodichloromethane))

75-27-4 35 16

Bromoethane (ethyl bromide) 74-96-4 40 16

@ Bromoform

(Listed As: Tribromomethane)

75-25-2 47 16

beta-Bromo-beta-nitrostyrene 7166-19-0 35 16

1-Bromopropane 106-94-5 40 16

@ Brown 95, C.I. Direct

(Listed As: C.I. Direct Brown

95)

16071-86-6 36 16

1,3-Butadiene 106-99-0 40 16

1,3-Butadiene 106-99-0 50 *

1,3-Butadiene 106-99-0 40 16

1,3-Butadiene 106-99-0 48 17

Butanal oxime 110-69-0 35 16

1,4-Butanediol 110-63-4 16

2,3-Butanedione 431-03-8 33 10

@ tert-Butanol

(Listed As: tert-Butyl

alcohol)

75-65-0 40 16

@ tert-Butanol

(Listed As: tert-Butyl

alcohol)

75-65-0 36 16

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ Butanone oxime

(Listed As: Methyl ethyl

ketoxime)

96-29-7 37 16

@ Butoxyethonol

(Listed As: 2-Butoxyethanol

(ethylene glycol monobutyl

ether))

111-76-2 36 16

@ Butoxyethonol

(Listed As: 2-Butoxyethanol

(ethylene glycol monobutyl

ether))

111-76-2 36 16

@ Butoxyethonol

(Listed As: 2-Butoxyethanol

(ethylene glycol monobutyl

ether))

111-76-2 40 16

@ Butoxyethanol

(Listed As: NTP-88 diet study

(EGMBE))

DIET88+EGMBE 52 *

2-Butoxyethanol (ethylene glycol

monobutyl ether)

111-76-2 36 16

2-Butoxyethanol (ethylene glycol

monobutyl ether)

111-76-2 36 16

2-Butoxyethanol (ethylene glycol

monobutyl ether)

111-76-2 40 16

tert-Butyl alcohol 75-65-0 40 16

tert-Butyl alcohol 75-65-0 36 16

Butylated hydroxytoluene 128-37-0 40 16

N-Butylbenzenesulfonamide 3622-84-2 32 5

Butyl benzyl phthalate 85-68-7 40 16

Butyl benzyl phthalate 85-68-7 38 16

Butyl benzyl phthalate 85-68-7 40 16

p-tert-Butylcatechol 98-29-3 36 16

p-tert-Butylcatechol 98-29-3 36 16

n-Butyl chloride 109-69-3 40 16

n-Butyl Glycidyl Ether 2426-08-6 50 *

tert-Butyl hydroperoxide 75-91-2 50 *

tert-Butyl hydroperoxide 75-91-2 50 *

t-Butylhydroquinone 1948-33-0 40 16

tert-Butyl perbenzoate 614-45-9 36 16

tert-Butylphenyl Diphenyl

Phosphate

56803-37-3 50 *

tert-Butylphenyl Diphenyl

Phosphate

56803-37-3 31 2

Butyraldehyde 123-72-8 50 *

gamma-Butyrolactone 96-48-0 40 16

@ C9 Alkylbenzenes

(Listed As: 1,2,4-

trimethylbenzene)

95-63-6 32 4

@ C9 Alkylbenzenes

(Listed As: Cumene)

98-82-8 31 2

@ C9 Alkylbenzenes

(Listed As: Cumene)

98-82-8 41 16

@ C9 Alkylbenzenes

(Listed As: 2-ethyltoluene)

611-14-3 31 2

@ C9 Alkylbenzenes

(Listed As: 3-ethyltoluene)

620-14-4 31 2

@ C9 Alkylbenzenes

(Listed As: 4-ethyltoluene)

622-96-8 31 2

Cadmium oxide 1306-19-0 36 16

Cadmium oxide 1306-19-0 36 16
Last Update: 09/18/2015 10:46 Management Status Report Page 10

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ Cadox TBH

(Listed As: tert-Butyl

hydroperoxide)

75-91-2 50 *

@ Cadox TBH

(Listed As: tert-Butyl

hydroperoxide)

75-91-2 50 *

Caffeine 58-08-2 50 *

Calcium chromate 13765-19-0 48 17

Calcium cyanamide 156-62-7 40 16

DL-Camphor 76-22-2 50 *

Caprolactam 105-60-2 40 16

Captan 133-06-2 40 16

Carbaryl 63-25-2 50 *

Carbon disulfide 75-15-0 50 *

Carbon disulfide 75-15-0 50 *

Carbon disulfide 75-15-0 50 *

Carbon tetrachloride 56-23-5 48 17

Carbromal 77-65-6 40 16

Cardio Transmitter Gene

Evaluation

CARDIOGENEVL 50 *

Carisoprodol 78-44-4 50 *

Carisoprodol 78-44-4 36 16

Carisoprodol 78-44-4 16

D-Carvone 2244-16-8 40 16

Castor oil 8001-79-4 36 16

Cedarwood oil 8000-27-9 34 14

Cell Phone Radiation: CDMA CELLPRADCDMA 33 8

Cell Phone Radiation: GSM CELLPRADGSM 33 8

Cellulose insulation CELLULOSEINS 36 16

@ CEM

(Listed As: bis(2-

Chloroethoxy)methane)

111-91-1 31 2

@ CEM

(Listed As: bis(2-

Chloroethoxy)methane)

111-91-1 40 16

@ CEM

(Listed As: bis(2-

Chloroethoxy)methane)

111-91-1 50 *

@ CEM

(Listed As: bis(2-

Chloroethoxy)methane)

111-91-1 50 *

Chemical mixture - drinking water

contaminants

CHEMMIXH2O 36 16

Chitosan 9012-76-4 50 *

Chloral hydrate 302-17-0 40 16

Chloral hydrate 302-17-0 36 16

Chloral hydrate 302-17-0 40 16

Chloramben 133-90-4 40 16

Chlorambucil 305-03-3 48 17

Chloraminated water CHLORAMINEMX 40 16

Chloramphenicol sodium succinate 982-57-0 50 *

Chlordane (analytical grade) 57-74-9 40 16

Chlordecone 143-50-0 40 16

Chlorendic acid 115-28-6 40 16

Chlorinated paraffins: C12, 60%

chlorine

108171-26-2 40 16

Chlorinated paraffins: C23, 43%

chlorine

108171-27-3 40 16

Chlorinated trisodium phosphate 56802-99-4 40 16

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Chlorinated water CHLORWATERMX 40 16

@ Chlorine/Sodium hypochlorite

(Listed As: Chlorinated water)

CHLORWATERMX 40 16

2-Chloroacetophenone (CN) 532-27-4 40 16

4-(Chloroacetyl)acetanilide 140-49-8 40 16

m-Chloroaniline 108-42-9 36 16

o-Chloroaniline 95-51-2 36 16

p-Chloroaniline 106-47-8 40 16

p-Chloroaniline hydrochloride 20265-96-7 40 16

o-Chlorobenzalmalononitrile (CS) 2698-41-1 40 16

Chlorobenzene 108-90-7 40 16

Chlorobenzilate 510-15-6 40 16

Chlorodibromomethane 124-48-1 40 16

3-Chloro-4-(dichloromethyl)-5-

hydroxy-2(5H)-furanone(MX)

77439-76-0 50 *

Chloroethane 75-00-3 40 16

2-Chloroethanol (ethylene

chlorohydrin)

107-07-3 40 16

bis(2-Chloroethoxy)methane 111-91-1 31 2

bis(2-Chloroethoxy)methane 111-91-1 40 16

bis(2-Chloroethoxy)methane 111-91-1 50 *

bis(2-Chloroethoxy)methane 111-91-1 50 *

2-Chloroethyltrimethylammonium

chloride

999-81-5 40 16

Chloroform 67-66-3 40 16

Chloromethyl methyl ether 107-30-2 48 17

3-Chloro-2-methylpropene 563-47-3 40 16

2-Chloromethylpyridine

hydrochloride

6959-47-3 40 16

3-Chloromethylpyridine

hydrochloride

6959-48-4 40 16

4-Chloro-2-nitroaniline 89-63-4 50 *

2-Chloronitrobenzene 88-73-3 36 16

4-Chloronitrobenzene 100-00-5 36 16

4-Chloro-m-phenylenediamine 5131-60-2 40 16

4-Chloro-o-phenylenediamine 95-83-0 40 16

2-Chloro-p-phenylenediamine

sulfate

61702-44-1 40 16

Chloropicrin 76-06-2 40 16

Chloroprene 126-99-8 38 16

Chloroprene 126-99-8 40 16

Chloroprene 126-99-8 50 *

Chloroprene 126-99-8 50 *

1-Chloro-2-propanol, technical 127-00-4 36 16

1-Chloro-2-propanol, technical 127-00-4 50 *

1-Chloro-2-propanol, technical 127-00-4 40 16

@ 1-Chloro-2-propanol, technical

(Transgenic LECM)

(Listed As: Transgenic

LECM (1-Chloro-2-propanol,

technical))

127-00-4 53 *

@ 1-Chloro-2-propanol, technical

(Transgenic LECM)

(Listed As: Transgenic

LECM (1-Chloro-2-propanol,

technical))

127-00-4 53 *

o-Chloropyridine 109-09-1 50 *

o-Chloropyridine 109-09-1 34 14

Chlorothalonil 1897-45-6 40 16
Last Update: 09/18/2015 10:46 Management Status Report Page 11

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

3-Chloro-p-toluidine 95-74-9 40 16

5-Chloro-o-toluidine 95-79-4 40 16

4-Chloro-o-toluidine

hydrochloride

3165-93-3 40 16

p-Chloro-a,a,a-trifluorotoluene 98-56-6 50 *

p-Chloro-a,a,a-trifluorotoluene 98-56-6 33 10

p-Chloro-a,a,a-trifluorotoluene 98-56-6 36 16

p-Chloro-a,a,a-trifluorotoluene 98-56-6 36 16

@ Chlorowax 40

(Listed As: Chlorinated

paraffins: C23, 43% chlorine)

108171-27-3 40 16

@ Chlorowax 500C

(Listed As: Chlorinated

paraffins: C12, 60% chlorine)

108171-26-2 40 16

Chlorpheniramine maleate 113-92-8 41 16

Chlorpropamide 94-20-2 41 16

Chromium 7440-47-3 48 17

Chromium picolinate monohydrate 27882-76-4 41 16

@ Chrysotile asbestos

(Listed As: Asbestos,

chrysotile(IR) + Dimethyl

hydrazine)

12001-29-5 39 16

@ Chrysotile asbestos

(Listed As: Asbestos,

chrysotile(IR) + Dimethyl

hydrazine)

12001-29-5 39 16

C.I. Phthalocyanine green 1328-53-6 50 *

C.I. Acid Orange 3 6373-74-6 41 16

C.I. Acid Orange 10 1936-15-8 41 16

C.I. Acid Red 14 3567-69-9 41 16

C.I. Acid Red 114 6459-94-5 41 16

@ C.I. Basic Green 4

(Listed As: Malachite green)

569-64-2 44 16

@ C.I. Basic Green 4

(Listed As: Malachite green)

569-64-2 37 16

@ C.I. Basic Red 1

(Listed As: Rhodamine 6G)

989-38-8 46 16

C.I. Basic Red 9

Monohydrochloride

569-61-9 41 16

C.I. Direct Black 38 1937-37-7 36 16

C.I. Direct Blue 6 2602-46-2 36 16

C.I. Direct Blue 6 2602-46-2 50 *

C.I. Direct Blue 15 2429-74-5 41 16

C.I. Direct Blue 218 28407-37-6 38 16

C.I. Direct Blue 218 28407-37-6 41 16

C.I. Direct Brown 95 16071-86-6 36 16

C.I. Disperse Blue 1 2475-45-8 41 16

C.I. Disperse Yellow 3 2832-40-8 41 16

1,8-Cineol 470-82-6 50 *

1,8-Cineol 470-82-6 51 *

Cinnamaldehyde 104-55-2 51 *

trans-Cinnamaldehyde 14371-10-9 41 16

trans-Cinnamaldehyde 14371-10-9 51 *

Cinnamyl anthranilate 87-29-6 41 16

C.I. Pigment Red 3 2425-85-6 41 16

C.I. Pigment Red 23 6471-49-4 41 16

C.I. Solvent Yellow 14 842-07-9 41 16

Citral 5392-40-5 41 16

Citral 5392-40-5 51 *

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Citral 5392-40-5 51 *

C.I. Vat Yellow 4 128-66-5 41 16

Clonitralid 1420-04-8 41 16

@ CN

(Listed As: 2-

Chloroacetophenone (CN))

532-27-4 40 16

Cobalt 7440-48-4 41 16

Cobalt sulfate heptahydrate 10026-24-1 16

Cobalt sulfate heptahydrate 10026-24-1 41 16

Coconut oil acid diethanolamine

condensate

68603-42-9 41 16

@ Coconut oil acid/diethanolamine

condensate

(Listed As: Coconut oil acid

diethanolamine condensate)

68603-42-9 41 16

@ Coconut oil acid diethanolamine

condensate (Transgenic LECM)

(Listed As: Transgenic

LECM (Coconut oil acid

diethanolamine condensate))

68603-42-9 53 *

@ Coconut oil acid diethanolamine

condensate (Transgenic LECM)

(Listed As: Transgenic

LECM (Coconut oil acid

diethanolamine condensate))

68603-42-9 53 *

Codeine 76-57-3 38 16

Codeine 76-57-3 41 16

@ Copper sulfate

(Listed As: Cupric sulfate)

7758-99-8 36 16

@ Copper sulfate

(Listed As: Cupric sulfate)

7758-99-8 36 16

Corn oil 8001-30-7 41 16

Coumaphos 56-72-4 41 16

Coumarin 91-64-5 38 16

Coumarin 91-64-5 41 16

m-Cresidine 102-50-1 41 16

p-Cresidine 120-71-8 41 16

p-Cresidine 120-71-8 51 *

m-Cresol 108-39-4 36 16

o-Cresol 95-48-7 36 16

p-Cresol 106-44-5 36 16

Cresols 1319-77-3 36 16

Cresols 1319-77-3 41 16

@ Crocidolite asbestos

(Listed As: Asbestos,

crocidolite)

12001-28-4 39 16

Crotonaldehyde 4170-30-3 51 *

Crude MCHM CRUDEMCHM 32 5

@ CS

(Listed As: oChlorobenzalmalononitrile

(CS))

2698-41-1 40 16

@ CTFT

(Listed As: p-Chloro-a,a,atrifluorotoluene)

98-56-6 50 *

@ CTFT

(Listed As: p-Chloro-a,a,atrifluorotoluene)

98-56-6 33 10

@ CTFT

(Listed As: p-Chloro-a,a,atrifluorotoluene)

98-56-6 36 16
Last Update: 09/18/2015 10:46 Management Status Report Page 12

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ CTFT

(Listed As: p-Chloro-a,a,atrifluorotoluene)

98-56-6 36 16

Cumene 98-82-8 31 2

Cumene 98-82-8 41 16

Cumene hydroperoxide 80-15-9 51 *

Cupferron 135-20-6 41 16

Cupric sulfate 7758-99-8 36 16

Cupric sulfate 7758-99-8 36 16

@ Curcumin (Prevention 4)

(Listed As: Prevention 4

(Curcumin))

458-37-7 52 *

Cyclanilide 113136-77-9 51 *

2-Cyclohexen-1-one 930-68-7 51 *

Cyclohexanone 108-94-1 48 17

Cyclohexanone oxime 100-64-1 36 16

Cyclohexene oxide 286-20-4 51 *

Cyclohexene oxide 286-20-4 51 *

Cyclohexene oxide 286-20-4 51 *

Cyclophosphamide 50-18-0 48 17

@ Cyclophosphamide monohydrate

(Transgenic model evaluation)

(Listed As: Transgenic model

evaluation (Cyclophosphamide

monohydrate))

6055-19-2 54 *

@ Cyclophosphamide monohydrate

(Transgenic model evaluation)

(Listed As: Transgenic model

evaluation (Cyclophosphamide

monohydrate))

6055-19-2 54 *

@ Cyclosporin A (Transgenic model

evaluation)

(Listed As: Transgenic model

evaluation (Cyclosporin A))

59865-13-3 54 *

@ Cyclosporin A (Transgenic model

evaluation)

(Listed As: Transgenic model

evaluation (Cyclosporin A))

59865-13-3 54 *

Cyfluthrin 68359-37-5 51 *

Cyprodinil 121552-61-2 51 *

Cytarabine 147-94-4 48 17

Cytembena 21739-91-3 41 16

Cytoxal alcohol 4465-94-5 48 17

@ 2,4-D (Peroxisome project)

(Listed As: Peroxisome project

(2,4-Dichlorophenoxyacetic

acid))

94-75-7 52 *

Dacarbazine 4342-03-4 48 17

Daminozide 1596-84-5 41 16

@ DAPSONE

(Listed As: 4,4'-

Sulfonyldianiline (Dapsone))

80-08-0 46 16

Daunomycin 20830-81-3 48 17

@ DBCP

(Listed As: 1,2-Dibromo-3-

chloropropane)

96-12-8 41 16

@ DBCP

(Listed As: 1,2-Dibromo-3-

chloropropane)

96-12-8 41 16

@ 1,3-DCP

(Listed As: 1,3-

Dichloropropene (Telone II))

542-75-6 41 16

D&C Red No. 9 5160-02-1 41 16

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

D&C Yellow No. 11 8003-22-3 36 16

D&C Yellow No. 11 8003-22-3 41 16

@ DDC (AIDS Initiative)

(Listed As: 2',3'-

Dideoxycytidine)

7481-89-2 51 *

@ DDC (AIDS Initiative)

(Listed As: 2',3'-

Dideoxycytidine)

7481-89-2 51 *

@ DDC (AIDS Initiative)

(Listed As: 2',3'-

Dideoxycytidine)

7481-89-2 51 *

o,p'-DDD 53-19-0 48 17

@ DDT

(Listed As: Dichlorodiphenyltrichloroethane

(DDT))

50-29-3 41 16

@ DDVP

(Listed As: Dichlorvos)

62-73-7 41 16

@ DDVP

(Listed As: Dichlorvos)

62-73-7 41 16

Decabromodiphenyl ether 1163-19-5 41 16

2,4-Decadienal 25152-84-5 51 *

2,4-Decadienal 25152-84-5 36 16

Decalin 91-17-8 41 16

@ DEHP

(Listed As: Di(2-ethylhexyl)

Phthalate)

117-81-7 33 10

@ DEHP

(Listed As: Di(2-ethylhexyl)

Phthalate)

117-81-7 33 10

@ DEHP

(Listed As: Di(2-ethylhexyl)

Phthalate)

117-81-7 51 *

@ DEHP

(Listed As: Di(2-ethylhexyl)

Phthalate)

117-81-7 51 *

@ DEHP

(Listed As: Di(2-ethylhexyl)

Phthalate)

117-81-7 42 16

Deoxynivalenol 51481-10-8 31 2

@ DEP

(Listed As: Diethyl phthalate)

84-66-2 42 16

@ DES (Transgenic model evaluation)

(Listed As: Transgenic model

evaluation (DES))

56-53-1 54 *

@ DES (Transgenic model evaluation)

(Listed As: Transgenic model

evaluation (DES))

56-53-1 54 *

@ DES (Transgenic model evaluation)

(Listed As: Transgenic model

evaluation (DES))

56-53-1 54 *

@ DES (Transgenic model evaluation)

(Listed As: Transgenic model

evaluation (DES))

56-53-1 54 *

@ DGRE

(Listed As: Diglycidyl

resorcinol ether (DGRE))

101-90-6 42 16

@ DHPT

(Listed As: 4-(6-Methyl-2-

benzothiazolyl)-benzenamine)

92-36-4 52 *

@ DIACETYL

(Listed As: 2,3-Butanedione)

431-03-8 33 10

Diallyl phthalate 131-17-9 41 16

Diallyl phthalate 131-17-9 41 16
Last Update: 09/18/2015 10:46 Management Status Report Page 13

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

4,4'-Diamino-2,2'-

stilbenedisulfonic acid, disodium

salt

7336-20-1 41 16

2,4-Diaminoanisole sulfate 39156-41-7 41 16

2,4-Diaminophenol dihydrochloride 137-09-7 41 16

2,4-Diaminotoluene (2,4-toluene

diamine)

95-80-7 41 16

@ 2,6-Diaminotoluene HCL

(Transgenic model evaluation)

(Listed As: Transgenic model

evaluation (2,6-Diaminotoluene

2HCl))

15481-70-6 54 *

@ 2,6-Diaminotoluene HCL

(Transgenic model evaluation)

(Listed As: Transgenic model

evaluation (2,6-Diaminotoluene

2HCl))

15481-70-6 54 *

@ 2,4-Diaminotoluene (Transgenic

model evaluation)

(Listed As: Transgenic

model evaluation (2,4-

Diaminotoluene))

95-80-7 54 *

@ 2,4-Diaminotoluene (Transgenic

model evaluation)

(Listed As: Transgenic

model evaluation (2,4-

Diaminotoluene))

95-80-7 54 *

Diarylanilide yellow 6358-85-6 41 16

Diazinon 333-41-5 41 16

Diazoaminobenzene 136-35-6 36 16

Dibenzo-p-dioxin 262-12-4 41 16

@ DIBP

(Listed As: Dibutyl Phthalate)

84-74-2 33 10

@ DIBP

(Listed As: Dibutyl Phthalate)

84-74-2 36 16

@ DIBP

(Listed As: Dibutyl Phthalate)

84-74-2 36 16

@ Dibromoacetic acid (Water

disinfection byproducts)

(Listed As: Water disinfection

byproducts (Dibromoacetic

acid))

631-64-1 55 *

@ Dibromoacetic acid (Water

disinfection byproducts)

(Listed As: Water disinfection

byproducts (Dibromoacetic

acid))

631-64-1 47 16

1,2-Dibromo-3-chloropropane 96-12-8 41 16

1,2-Dibromo-3-chloropropane 96-12-8 41 16

@ Dibromodicyanobutane

(Listed As: 1,2-Dibromo-2,4-

dicyanobutane)

35691-65-7 51 *

@ Dibromodicyanobutane

(Listed As: 1,2-Dibromo-2,4-

dicyanobutane)

35691-65-7 51 *

@ Dibromodicyanobutane

(Listed As: 1,2-Dibromo-2,4-

dicyanobutane)

35691-65-7 36 16

@ Dibromodicyanobutane

(Listed As: 1,2-Dibromo-2,4-

dicyanobutane)

35691-65-7 41 16

1,2-Dibromo-2,4-dicyanobutane 35691-65-7 51 *

1,2-Dibromo-2,4-dicyanobutane 35691-65-7 51 *

1,2-Dibromo-2,4-dicyanobutane 35691-65-7 36 16

1,2-Dibromo-2,4-dicyanobutane 35691-65-7 41 16

Dibromodulcitol 10318-26-0 48 17

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

1,2-Dibromoethane 106-93-4 41 16

1,2-Dibromoethane 106-93-4 41 16

Dibromomannitol 488-41-5 48 17

2,3-Dibromo-1-propanol 96-13-9 41 16

Dibutyl Phthalate 84-74-2 33 10

Dibutyl Phthalate 84-74-2 36 16

Dibutyl Phthalate 84-74-2 36 16

@ Dibutyl phthalate (Peroxisome

project)

(Listed As: Peroxisome project

(Dibutyl phthalate))

84-74-2 52 *

Dibutyltin diacetate 1067-33-0 41 16

@ DIC

(Listed As:

Diisopropylcarbodiimide)

693-13-0 38 16

@ DIC

(Listed As:

Diisopropylcarbodiimide)

693-13-0 35 16

@ DIC

(Listed As:

Diisopropylcarbodiimide)

693-13-0 35 16

@ DIC

(Listed As:

Diisopropylcarbodiimide)

693-13-0 42 16

@ Dichloroacetic acid (Water

disinfection byproducts)

(Listed As: Water disinfection

byproducts (Dichloroacetic

acid))

79-43-6 55 *

@ Dichloroacetic acid (Water

disinfection mode)

(Listed As: Water disinfection

model (Dichloroacetic acid))

79-43-6 35 16

@ Dichloroacetic acid (Water

disinfection mode)

(Listed As: Water disinfection

model (Dichloroacetic acid))

79-43-6 35 16

@ Dichloroacetic acid (Water

disinfection mode)

(Listed As: Water disinfection

model (Dichloroacetic acid))

79-43-6 35 16

1,2-Dichlorobenzene

(o-dichlorobenzene)

95-50-1 41 16

1,4-Dichlorobenzene

(p-dichlorobenzene)

106-46-7 41 16

5,6-Dichloro-2-benzothiazolamine 24072-75-1 51 *

2,7-Dichlorodibenzo-p-dioxin 33857-26-0 41 16

@ 1,2-Dichloro-1,1-difluoroethane

(Halogenated ethanes CS)

(Listed As: Halogenated

ethanes CS (1,2-Dichloro-1,1-

difluoroethane))

1649-08-7 36 16

p,p'-Dichlorodiphenyl

dichloroethylene

72-55-9 41 16

p,p'-Dichlorodiphenyl sulfone 80-07-9 38 16

p,p'-Dichlorodiphenyl sulfone 80-07-9 41 16

Dichlorodiphenyltrichloroethane

(DDT)

50-29-3 41 16

1,1-Dichloroethane 75-34-3 41 16

1,2-Dichloroethane 107-06-2 41 16

1,2-Dichloroethane 107-06-2 36 16

1,2-Dichloroethane 107-06-2 16

1,2-Dichloroethane 107-06-2 16
Last Update: 09/18/2015 10:46 Management Status Report Page 14

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ Dichloroethylene,1,1

(Listed As: Vinylidene

Chloride)

75-35-4 47 16

@ Dichloroethylene,1,1

(Listed As: Vinylidene

Chloride)

75-35-4 47 16

cis & trans 1,2-Dichloroethylene 540-59-0 51 *

cis-1,2-Dichloroethylene 156-59-2 51 *

trans-1,2-Dichloroethylene 156-60-5 51 *

trans-1,2-Dichloroethylene 156-60-5 51 *

trans-1,2-Dichloroethylene 156-60-5 36 16

@ Dichloromethane

(Listed As: Methylene

chloride)

75-09-2 44 16

Dichloromethotrexate 528-74-5 48 17

2,4-Dichlorophenol 120-83-2 41 16

2,6-Dichloro-p-phenylenediamine 609-20-1 41 16

1,2-Dichloropropane (propylene

dichloride)

78-87-5 41 16

1,3-Dichloropropene (Telone II) 542-75-6 41 16

2,3-Dichloropropylene 78-88-6 51 *

Dichlorvos 62-73-7 41 16

Dichlorvos 62-73-7 41 16

Dicofol 115-32-2 41 16

Dicyclohexylcarbodiimide 538-75-0 35 16

Dicyclohexylcarbodiimide 538-75-0 35 16

Dicyclohexylcarbodiimide 538-75-0 35 16

N,N'-Dicyclohexylthiourea 1212-29-9 41 16

2',3'-Dideoxycytidine 7481-89-2 51 *

2',3'-Dideoxycytidine 7481-89-2 51 *

2',3'-Dideoxycytidine 7481-89-2 51 *

@ 2',3'-Dideoxycytidine (AIDS

Initiative)

(Listed As: 2',3'-

Dideoxycytidine)

7481-89-2 51 *

@ 2',3'-Dideoxycytidine (AIDS

Initiative)

(Listed As: 2',3'-

Dideoxycytidine)

7481-89-2 51 *

@ 2',3'-Dideoxycytidine (AIDS

Initiative)

(Listed As: 2',3'-

Dideoxycytidine)

7481-89-2 51 *

Dieldrin 60-57-1 42 16

Dieldrin 60-57-1 42 16

Diesel fuel marine DIESELFUEL 42 16

Diet Evaluation Study DIETEVAL 51 *

Diethanolamine 111-42-2 36 16

Diethanolamine 111-42-2 36 16

Diethanolamine 111-42-2 42 16

@ Diethanolamine (Transgenic LECM)

(Listed As: Transgenic LECM

(diethanolamine))

111-42-2 54 *

Diethylamine 109-89-7 42 16

Di(2-ethylhexyl)adipate 103-23-1 42 16

Di(2-ethylhexyl) Phthalate 117-81-7 33 10

Di(2-ethylhexyl) Phthalate 117-81-7 33 10

Di(2-ethylhexyl) Phthalate 117-81-7 51 *

Di(2-ethylhexyl) Phthalate 117-81-7 51 *

Di(2-ethylhexyl) Phthalate 117-81-7 42 16

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ Di (2-ethylhexyl) phthalate

(Transgenic model evaluation)

(Listed As: Transgenic model

evaluation (Di(2-ethylhexyl)

phthalate))

117-81-7 54 *

@ Di (2-ethylhexyl) phthalate

(Transgenic model evaluation)

(Listed As: Transgenic model

evaluation (Di(2-ethylhexyl)

phthalate))

117-81-7 54 *

Di(p-ethylphenyl)dichloroethane 72-56-0 42 16

Diethyl phthalate 84-66-2 42 16

Diethyl phthalate/dimethyl

phthalate

DIETH/DIMETH 42 16

N,N'-Diethylthiourea 105-55-5 42 16

@ 1,2-Difluoro-1,1,2,2-

tetrachloroethane (Halogenated

ethanes CS)

(Listed As: Halogenated

ethanes CS (1,2-Difluoro1,1,2,2-tetrachloroethane))

76-12-0 36 16

Diglycidyl resorcinol ether

(DGRE)

101-90-6 42 16

3,4-Dihydrocoumarin 119-84-6 38 16

3,4-Dihydrocoumarin 119-84-6 42 16

1,2-Dihydro-2,2,4-

trimethylquinoline (monomer)

147-47-7 38 16

1,2-Dihydro-2,2,4-

trimethylquinoline (monomer)

147-47-7 42 16

1,2-Dihydro-2,2,4-

trimethylquinoline (monomer)

147-47-7 38 16

1,2-Dihydro-2,2,4-

trimethylquinoline (monomer)

147-47-7 42 16

1,2-Dihydro-2,2,4-

trimethylquinoline (polymer)

26780-96-1 51 *

Diisopropylcarbodiimide 693-13-0 38 16

Diisopropylcarbodiimide 693-13-0 35 16

Diisopropylcarbodiimide 693-13-0 35 16

Diisopropylcarbodiimide 693-13-0 42 16

Dimethoate 60-51-5 42 16

Dimethoxane 828-00-2 42 16

2,4-Dimethoxyaniline

hydrochloride

54150-69-5 42 16

3,3'-Dimethoxybenzidine

dihydrochloride

20325-40-0 42 16

3,3'-Dimethoxybenzidine-4,4'-

diisocyanate

91-93-0 42 16

Dimethylamine Borane 74-94-2 32 5

Dimethylaminopropyl chloride,

hydrochloride

5407-04-5 51 *

Dimethylaminopropyl chloride,

hydrochloride

5407-04-5 36 16

N,N-Dimethylaniline 121-69-7 42 16

@ 7,12-Dimethylbenz(A)anthracene

(DMBA)

(Listed As: Init/prom

comparative mouse study (DMBA/

TPA/BPO/MNNG))

INIT/PROM 43 16

@ 7,12-Dimethylbenz(A)anthracene

(DMBA)

(Listed As: Init/prom

comparative mouse study (DMBA/

TPA/BPO/MNNG))

INIT/PROM 43 16
Last Update: 09/18/2015 10:46 Management Status Report Page 15

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ 7,12-Dimethylbenz(A)anthracene

(DMBA)

(Listed As: Init/prom

comparative mouse study (DMBA/

TPA/BPO/MNNG))

INIT/PROM 43 16

3,3'-Dimethylbenzidine

dihydrochloride

612-82-8 42 16

Dimethylcarbamoyl chloride 79-44-7 48 17

Dimethylformamide 68-12-2 16

Dimethyl hydrazine (DMH) 57-14-7 48 17

1,2-Dimethylhydrazine 2HCl 306-37-6 48 17

Dimethyl hydrogen phosphite 868-85-9 42 16

Dimethyl methylphosphonate 756-79-6 42 16

Dimethyl

morpholinophosphoramidate

597-25-1 42 16

Dimethyl terephthalate 120-61-6 42 16

N,N-Dimethyl-p-toluidine 99-97-8 33 10

N,N-Dimethyl-p-toluidine 99-97-8 51 *

N,N-Dimethyl-p-toluidine 99-97-8 42 16

Dimethylvinyl chloride (DMVC) 513-37-1 42 16

2,2'-Dimorpholinodiethyl Ether 6425-39-4 31 3

2,4-Dinitrotoluene 121-14-2 42 16

1,4-Dioxane 123-91-1 42 16

Dioxathion 78-34-2 42 16

@ Dioxin mixture (Toxic equivalency

factor evaluation)

(Listed As: Toxic equivalency

factor evaluation (Dioxin

mixture))

TEFDIOXINMIX 47 16

Diphenhydramine hydrochloride 147-24-0 42 16

1,3-Diphenylguanidine 102-06-7 16

5,5-Diphenylhydantoin (phenytoin) 57-41-0 42 16

@ DIPHONE

(Listed As: Bisphenol S)

80-09-1 31 4

Dipropylene glycol 25265-71-8 38 16

Dipropylene glycol 25265-71-8 42 16

Dipropylene glycol phenyl ether 51730-94-0 32 4

2,5-Dithiobiurea 142-46-1 42 16

Divinylbenzene 1321-74-0 51 *

Divinylbenzene 1321-74-0 42 16

@ DMBA + EMF init prom

(Listed As: Magnetic fields +

DMBA initiation promotion)

EMF+DMBA 37 16

@ DMBA/TPA/BPO/MNNG

(Listed As: Init/prom

comparative mouse study (DMBA/

TPA/BPO/MNNG))

INIT/PROM 43 16

@ DMBA/TPA/BPO/MNNG

(Listed As: Init/prom

comparative mouse study (DMBA/

TPA/BPO/MNNG))

INIT/PROM 43 16

@ DMBA/TPA/BPO/MNNG

(Listed As: Init/prom

comparative mouse study (DMBA/

TPA/BPO/MNNG))

INIT/PROM 43 16

@ DMDEE

(Listed As: 2,2'-

Dimorpholinodiethyl Ether)

6425-39-4 31 3

@ DMVC

(Listed As: Dimethylvinyl

chloride (DMVC))

513-37-1 42 16

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ DON

(Listed As: Deoxynivalenol)

51481-10-8 31 2

Dong quai Angelica sinensis root

extract

299184-76-2 31 2

Doxylamine 469-21-6 42 16

Phenolic Benzotriazoles

(Drometrizole)

2440-22-4 32 4

@ EDTA

(Listed As: Trisodium

ethylenediaminetetraacetate

trihydrate (EDTA))

150-38-9 47 16

@ EGMBE

(Listed As: 2-Butoxyethanol

(ethylene glycol monobutyl

ether))

111-76-2 36 16

@ EGMBE

(Listed As: 2-Butoxyethanol

(ethylene glycol monobutyl

ether))

111-76-2 36 16

@ EGMBE

(Listed As: 2-Butoxyethanol

(ethylene glycol monobutyl

ether))

111-76-2 40 16

@ EGMEE

(Listed As: Ethylene glycol

monoethyl ether (EGMEE))

110-80-5 36 16

@ EGMEE

(Listed As: Ethylene glycol

monoethyl ether (EGMEE))

110-80-5 36 16

@ EGMME

(Listed As: Ethylene Glycol

Monomethyl Ether (EGMME))

109-86-4 36 16

@ EGMME

(Listed As: Ethylene Glycol

Monomethyl Ether (EGMME))

109-86-4 36 16

Elmiron (sodium

pentosanpolysulfate)

37319-17-8 42 16

Elmiron (sodium

pentosanpolysulfate)

37319-17-8 38 16

Emetine hydrochloride 316-42-7 42 16

@ EMF + DMBA init prom

(Listed As: Magnetic fields +

DMBA initiation promotion)

EMF+DMBA 37 16

Emodin 518-82-1 42 16

Endocrine disruptor (Ethinyl

estradiol)

57-63-6 42 16

Endocrine disruptor (Ethinyl

estradiol)

57-63-6 42 16

Endocrine disruptor (Ethinyl

estradiol)

57-63-6 42 16

Endocrine disruptor (Genistein) 446-72-0 42 16

Endosulfan 115-29-7 42 16

Endrin 72-20-8 42 16

Ephedrine + caffeine combination EPHEDCOMBO 51 *

Ephedrine + caffeine combination EPHEDCOMBO 51 *

Ephedrine sulfate 134-72-5 42 16

Epichlorhydrin 106-89-8 48 17

Epinephrine hydrochloride 55-31-2 42 16

1,2-Epoxybutane 106-88-7 42 16

Erythromycin stearate 643-22-1 42 16

Estradiol mustard 22966-79-6 42 16

Estragole 140-67-0 51 *

Estragole 140-67-0 36 16
Last Update: 09/18/2015 10:46 Management Status Report Page 16

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Ethanol 64-17-5 42 16

Ethanone, 1-(1,2,3,4,5,6,7,8-

Octahydro-2,3,8,8-Tetramethyl-2-

Naphthalenyl)- (Iso-E Super®;

OTNE)

54464-57-2 34 14

@ Ethinyl estradiol (Endocrine

disruptor)

(Listed As: Endocrine

disruptor (Ethinyl estradiol))

57-63-6 42 16

@ Ethinyl estradiol (Endocrine

disruptor)

(Listed As: Endocrine

disruptor (Ethinyl estradiol))

57-63-6 42 16

@ Ethinyl estradiol (Endocrine

disruptor)

(Listed As: Endocrine

disruptor (Ethinyl estradiol))

57-63-6 42 16

@ Ethinyl estradiol (Transgenic

model evaluation)

(Listed As: Transgenic

model evaluation (Ethinyl

estradiol))

57-63-6 54 *

@ Ethinyl estradiol (Transgenic

model evaluation)

(Listed As: Transgenic

model evaluation (Ethinyl

estradiol))

57-63-6 54 *

Ethionamide 536-33-4 42 16

@ Ethoxyethanol

(Listed As: NTP-88 diet study

(EGMEE))

DIET88+EGMEE 52 *

Ethoxyquin 91-53-2 51 *

Ethyl acrylate 140-88-5 42 16

Ethylbenzene 100-41-4 36 16

Ethylbenzene 100-41-4 42 16

@ Ethyl bromide

(Listed As: Bromoethane (ethyl

bromide))

74-96-4 40 16

@ Ethyl chloride

(Listed As: Chloroethane)

75-00-3 40 16

@ Ethylene chlorohydrin

(Listed As: 2-Chloroethanol

(ethylene chlorohydrin))

107-07-3 40 16

@ Ethylene dibromide

(Listed As: 1,2-Dibromoethane)

106-93-4 41 16

@ Ethylene dibromide

(Listed As: 1,2-Dibromoethane)

106-93-4 41 16

@ Ethylene dichloride

(Listed As: 1,2-

Dichloroethane)

107-06-2 41 16

@ Ethylene dichloride

(Listed As: 1,2-

Dichloroethane)

107-06-2 36 16

@ Ethylene dichloride

(Listed As: 1,2-

Dichloroethane)

107-06-2 16

@ Ethylene dichloride

(Listed As: 1,2-

Dichloroethane)

107-06-2 16

Ethylene glycol 107-21-1 42 16

Ethylene glycol monoethyl ether

(EGMEE)

110-80-5 36 16

Ethylene glycol monoethyl ether

(EGMEE)

110-80-5 36 16

Ethylene Glycol Monomethyl Ether

(EGMME)

109-86-4 36 16

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Ethylene Glycol Monomethyl Ether

(EGMME)

109-86-4 36 16

Ethylene oxide 75-21-8 42 16

Ethylene thiourea (ETU) 96-45-7 42 16

2-Ethylhexyl Diphenyl Phosphate 1241-94-7 51 *

@ 1-Ethyl-3-methylimidazolium

Chloride (Ionic Liquid)

(Listed As: Ionic Liquid: 1-

Ethyl-3-methylimidazolium

Chloride)

65039-09-0 32 5

Ethyl tellurac 20941-65-5 42 16

@ Ethyl tellurac

(Listed As: Ethyl tellurac)

20941-65-5 42 16

2-ethyltoluene 611-14-3 31 2

3-ethyltoluene 620-14-4 31 2

4-ethyltoluene 622-96-8 31 2

Ethyl vinyl ketone 1629-58-9 51 *

Eugenol 97-53-0 42 16

@ EVK

(Listed As: Ethyl vinyl

ketone)

1629-58-9 51 *

FD & C Yellow No. 6 2783-94-0 42 16

Feed restriction studies FEEDRESTRICT 42 16

Formulated fenaminosulf 140-56-7 42 16

Fenthion 55-38-9 42 16

Ferrocene 102-54-5 51 *

@ Firemaster FF-1

(Listed As: Polybrominated

biphenyl mixture (Firemaster

FF-1))

67774-32-7 45 16

@ Firemaster FF-1

(Listed As: Polybrominated

biphenyl mixture (Firemaster

FF-1))

67774-32-7 45 16

Fish project 1 (2,2-

bis(Bromomethyl)-1,3-propanediol)

3296-90-0 42 16

Fish project 1 (2,2-

bis(Bromomethyl)-1,3-propanediol)

3296-90-0 43 16

Fish Project 1 (Nitromethane) 75-52-5 43 16

Fish Project 1 (Nitromethane) 75-52-5 43 16

Fish project 1

(1,2,3-Trichloropropane)

96-18-4 43 16

Fish project 1

(1,2,3-Trichloropropane)

96-18-4 43 16

@ Flame Retardant 1

(Listed As: Triphenyl

Phosphate)

115-86-6 31 2

@ Flame Retardant 1

(Listed As: Triphenyl

Phosphate)

115-86-6 32 5

@ Flame Retardant 1

(Listed As: 2-Ethylhexyl

Diphenyl Phosphate)

1241-94-7 51 *

@ Flame Retardant 1

(Listed As: Tricresyl

Phosphate)

1330-78-5 54 *

@ Flame Retardant 1

(Listed As: Tricresyl

Phosphate)

1330-78-5 31 2

@ Flame Retardant 1

(Listed As: Tricresyl

Phosphate)

1330-78-5 54 *
Last Update: 09/18/2015 10:46 Management Status Report Page 17

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ Flame Retardant 1

(Listed As: Tricresyl

Phosphate)

1330-78-5 47 16

@ Flame Retardant 1

(Listed As: Isodecyl Diphenyl

Phosphate)

29761-21-5 51 *

@ Flame Retardant 1

(Listed As: tert-Butylphenyl

Diphenyl Phosphate)

56803-37-3 50 *

@ Flame Retardant 1

(Listed As: tert-Butylphenyl

Diphenyl Phosphate)

56803-37-3 31 2

@ Flame Retardant 1

(Listed As: Isopropylated

Phenol Phosphate)

68937-41-7 32 5

@ Flame Retardant 1

(Listed As: Isopropylated

Phenol Phosphate)

68937-41-7 51 *

@ Flame Retardant 2

(Listed As: Decabromodiphenyl

ether)

1163-19-5 41 16

@ Flame Retardant 2

(Listed As: 2,2',4,4'-

Tetrabromodiphenyl Ether (BDE47))

5436-43-1 53 *

@ Flame Retardant 2

(Listed As: 2,2',4,4'-

Tetrabromodiphenyl Ether (BDE47))

5436-43-1 31 2

@ Flame Retardant 2

(Listed As: 2,2',4,4'-

Tetrabromodiphenyl Ether (BDE47))

5436-43-1 32 4

@ Flame Retardant 2

(Listed As:

Tetrabromobisphenol A-bis(2,3-

dibromopropyl ether))

21850-44-2 34 12

@ Flaxseed oil + melatonin

(Prevention 1)

(Listed As: Prevention 1

(Flaxseed oil + melatonin))

FLAXSEED+MEL 52 *

@ Flaxseed oil (Prevention 1)

(Listed As: Prevention 1

(Flaxseed oil))

8001-26-1 52 *

Fluometuron 2164-17-2 43 16

Fluorotelomer Alcohol 8+2 678-39-7 31 3

Flusilazole 85509-19-9 51 *

Flutamide 13311-84-7 51 *

Formaldehyde 50-00-0 51 *

Formaldehyde 50-00-0 51 *

Formamide 75-12-7 36 16

Formamide 75-12-7 43 16

Formic acid 64-18-6 36 16

Fumonisin B1 116355-83-0 38 16

Fumonisin B1 116355-83-0 43 16

Furan 110-00-9 33 8

Furan 110-00-9 43 16

Furfural 98-01-1 43 16

Furfuryl alcohol 98-00-0 38 16

Furfuryl alcohol 98-00-0 43 16

@ Furfuryl alcohol (Transgenic

LECM)

(Listed As: Transgenic LECM

(Furfuryl alcohol))

98-00-0 53 *

Furosemide 54-31-9 43 16

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Gallium arsenide 1303-00-0 38 16

Gallium arsenide 1303-00-0 43 16

Gallium oxide 12024-21-4 51 *

Garcinia Cambogia Extract 90045-23-1 32 5

@ GCE

(Listed As: Garcinia Cambogia

Extract)

90045-23-1 32 5

@ Gemfibrozil (Peroxisome project)

(Listed As: Peroxisome project

(Gemfibrozil))

25812-30-0 52 *

@ Genistein (Endocrine disruptor)

(Listed As: Endocrine

disruptor (Genistein))

446-72-0 42 16

@ Gentian violet

(Listed As: Hexamethyl-prosaniline chloride)

548-62-9 43 16

@ Gentian violet

(Listed As: Hexamethyl-prosaniline chloride)

548-62-9 43 16

Geranyl acetate 105-87-3 43 16

Ginkgo biloba extract 90045-36-6 43 16

Ginkgo biloba extract 90045-36-6 31 2

Ginseng 50647-08-0 43 16

Glucosamine 3416-24-8 51 *

Glucosamine Hydrochloride +

Chondroitin Sulfate

GLUCOSCHONDN 51 *

Glutaraldehyde 111-30-8 36 16

Glutaraldehyde 111-30-8 43 16

Glycidamide 5694-00-8 43 16

Glycidol 556-52-5 43 16

@ Glycidol (Transgenic model

evaluation II)

(Listed As: Transgenic model

evaluation II (Glycidol))

556-52-5 35 16

@ Glycol

(Listed As: Polysorbate 80

(glycol))

9005-65-6 45 16

Glyoxal 107-22-2 51 *

Glyphosate 1071-83-6 36 16

Glyphosate 1071-83-6 36 16

Goldenseal root powder GOLDENSEALRT 36 16

Goldenseal root powder GOLDENSEALRT 43 16

@ Green, Phthalocyanine

(Listed As: C.I.

Phthalocyanine green)

1328-53-6 50 *

Green Tea Extract GREENTEAEXTR 34 14

Guanazole 1455-77-2 48 17

Guar gum 9000-30-0 43 16

Gum Arabic 9000-01-5 43 16

Gum Guggul Extract GUMGUGGULEXT 51 *

Halogenated ethanes CS

(1,2-Dichloro-1,1-difluoroethane)

1649-08-7 36 16

Halogenated ethanes CS (1,2-

Difluoro-1,1,2,2-

tetrachloroethane)

76-12-0 36 16

Halogenated ethanes CS

(Hexachloroethane)

67-72-1 36 16

Halogenated ethanes CS

(Pentabromoethane)

75-95-6 36 16

Halogenated ethanes CS

(Pentachloroethane)

76-01-7 36 16
Last Update: 09/18/2015 10:46 Management Status Report Page 18

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Halogenated ethanes CS

(1,1,1,2-Tetrabromoethane)

630-16-0 36 16

Halogenated ethanes CS

(1,1,2,2-Tetrabromoethane)

79-27-6 37 16

Halogenated ethanes CS

(1,1,1,2-Tetrachloroethane)

630-20-6 37 16

Halogenated ethanes CS

(1,1,2,2-Tetrachloroethane)

79-34-5 37 16

Halogenated ethanes CS

(1,1,1-Trichloroethane)

71-55-6 37 16

Halogenated ethanes CS (1,1,1-

Trichloro-2,2,2-trifluoroethane)

354-58-5 37 16

@ Harness (R)

(Listed As: Acetochlor)

34256-82-1 49 *

HC Blue 1 2784-94-3 43 16

HC Blue 2 33229-34-4 43 16

HC Red 3 2871-01-4 43 16

HC Yellow 4 59820-43-8 43 16

Heptachlor 76-44-8 43 16

2,2',4,4',5,5'-Hexabromodiphenyl

ether (PBDE 153)

68631-49-2 31 2

Hexachlorobenzene 118-74-1 34 14

@ 2,2'-4,4',5,5'-hexachlorobiphenyl

(PCB 153) (Toxic equivalency

factor evaluation)

(Listed As: Toxic equivalency

factor evaluation (PCB

153- 2,2'-4,4',5,5'-

hexachlorobiphenyl))

35065-27-1 47 16

Hexachloro-1,3-butadiene 87-68-3 37 16

Hexachlorocyclopentadiene 77-47-4 43 16

1,2,3,6,7,8-Hexachlorodibenzo-pdioxin57653-85-7 43 16

1,2,3,6,7,8-Hexachlorodibenzo-pdioxin57653-85-7 43 16

Hexachloroethane 67-72-1 43 16

Hexachloroethane 67-72-1 43 16

@ Hexachloroethane (Halogenated

ethanes CS)

(Listed As: Halogenated

ethanes CS (Hexachloroethane))

67-72-1 36 16

Hexachlorophene 70-30-4 43 16

2,4-Hexadienal 142-83-6 38 16

2,4-Hexadienal 142-83-6 43 16

Hexamethyl-p-rosaniline chloride 548-62-9 43 16

Hexamethyl-p-rosaniline chloride 548-62-9 43 16

Hexanamide 628-02-4 48 17

1,6-Hexanediamine dihydrochloride 6055-52-3 37 16

1,6-Hexanediamine dihydrochloride 6055-52-3 37 16

n-Hexane 110-54-3 37 16

4-Hexylresorcinol 136-77-6 43 16

@ HMB

(Listed As: 2-Hydroxy-4-

methoxybenzophenone)

131-57-7 33 10

@ HMB

(Listed As: 2-Hydroxy-4-

methoxybenzophenone)

131-57-7 37 16

@ HMB

(Listed As: 2-Hydroxy-4-

methoxybenzophenone)

131-57-7 37 16

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ HMB

(Listed As: 2-Hydroxy-4-

methoxybenzophenone)

131-57-7 37 16

@ 4-HPR (Retinoid project 6)

(Listed As: Retinoid project 6

(4-HPR))

65646-68-6 53 *

Hydrazobenzene 122-66-7 43 16

Hydrochlorothiazide 58-93-5 43 16

Hydroquinone 123-31-9 43 16

Phenolic Benzotriazoles (3-(2HBenzotriazol-2-yl)-5-(1,1-

dimethylethyl)-4-

hydroxybenzenepropanoic acid,

octyl ester)

84268-23-5 32 4

2-Hydroxy-4-methoxybenzophenone 131-57-7 33 10

2-Hydroxy-4-methoxybenzophenone 131-57-7 37 16

2-Hydroxy-4-methoxybenzophenone 131-57-7 37 16

2-Hydroxy-4-methoxybenzophenone 131-57-7 37 16

5-(Hydroxymethyl)-2-furfural 67-47-0 37 16

5-(Hydroxymethyl)-2-furfural 67-47-0 43 16

8-Hydroxyquinoline 148-24-3 43 16

@ 8-Hydroxyquinoline (Transgenic

model evaluation)

(Listed As: Transgenic

model evaluation (8-

Hydroxyquinoline))

148-24-3 54 *

@ 8-Hydroxyquinoline (Transgenic

model evaluation)

(Listed As: Transgenic

model evaluation (8-

Hydroxyquinoline))

148-24-3 54 *

Hydroxyurea 127-07-1 48 17

ICRF-159 21416-87-5 43 16

@ IDDP

(Listed As: Isodecyl Diphenyl

Phosphate)

29761-21-5 51 *

IPD (3,3'-iminobis-1-propanol

dimethanesulfonate (ester)

hydrochloride)

3458-22-8 43 16

Indium phosphide 22398-80-7 43 16

Indole-3-carbinol 700-06-1 34 12

Indole-3-carbinol 700-06-1 34 14

@ Indole-3-carbinol (Prevention 4)

(Listed As: Prevention 4

(Indole-3-carbinol))

700-06-1 52 *

Indoxacarb 173584-44-6 51 *

Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

INIT/PROM 43 16

Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

INIT/PROM 43 16

Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

INIT/PROM 43 16

Insertional mutagenesis

(Radiation Levels)

INSERTMUTRAD 51 *

Insertional mutagenesis II (SIN

vector)

INSERTMUT2 51 *

Insertional Mutagenesis -

Definitive Vector Study

INSERTMUT3 33 8

Insertional Mutagenesis -

Definitive Vector Study

INSERTMUT3 32 4

Insertional mutagenesis (LTR/SIN

vectors)

INSERTMUT 51 *

Interferon AD (AIDS Initiative) INTERFERONAD 43 16
Last Update: 09/18/2015 10:46 Management Status Report Page 19

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Interferon AD +

3'-azido-3'-deoxythymidine (AIDS

Initiative)

INTAZTCOMB 43 16

Interferon AD + ddC (AIDS

Initiative)

INTDDCCOMB 51 *

Interferon A (AIDS Initiative) 76543-88-9 43 16

Iodinated glycerol 5634-39-9 43 16

Iodoform 75-47-8 43 16

Ionic Liquid:

1-Butyl-3-methylimidazolium

Chloride

79917-90-1 32 5

Ionic Liquid:

1-Butyl-1-methylpyrrolidinium

Chloride

479500-35-1 32 5

Ionic Liquid: N-Butylpyridinium

Chloride

1124-64-7 32 5

Ionic Liquid:

1-Ethyl-3-methylimidazolium

Chloride

65039-09-0 32 5

Ionic liquid Toxicity IONICLIQUIDS 51 *

Isobutene 115-11-7 43 16

Isobutyl nitrite 542-56-3 43 16

Isobutyraldehyde 78-84-2 38 16

Isobutyraldehyde 78-84-2 43 16

Isodecyl Diphenyl Phosphate 29761-21-5 51 *

Isoeugenol 97-54-1 43 16

Isophorone 78-59-1 43 16

Isophosphamide 3778-73-2 43 16

Isoprene 78-79-5 37 16

Isoprene 78-79-5 43 16

Isoprene 78-79-5 16

Isopropylated Phenol Phosphate 68937-41-7 32 5

Isopropylated Phenol Phosphate 68937-41-7 51 *

Kava kava extract 9000-38-8 43 16

@ Kelthane

(Listed As: Dicofol)

115-32-2 41 16

@ Kepone

(Listed As: Chlordecone)

143-50-0 40 16

Lasiocarpine 303-34-4 43 16

Lauric acid diethanolamine

condensate

120-40-1 43 16

@ Lauric acid diethanolamine

condensate (Transgenic LECM)

(Listed As: Transgenic LECM

(Lauric acid diethanolamine

condensate))

120-40-1 53 *

@ Lauric acid diethanolamine

condensate (Transgenic LECM)

(Listed As: Transgenic LECM

(Lauric acid diethanolamine

condensate))

120-40-1 53 *

Lead(2+) acetate 301-04-2 51 *

Lead contaminated soil PBCONTAMSOIL 51 *

Lead dimethyldithiocarbamate 19010-66-3 43 16

Lead ores LEADORES 51 *

Lead oxide 1317-36-8 51 *

Lead sulfide 1314-87-0 51 *

Lead sulfide 1314-87-0 51 *

Leucomalachite green 129-73-7 43 16

Leucomalachite green 129-73-7 37 16

Libby Amphibole 1318-09-8 32 4

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

D-Limonene 5989-27-5 44 16

Lindane 58-89-9 44 16

Lipopolysaccharides from

Escherichia coli

ECOLI_LPS 51 *

Lithocholic acid 434-13-9 44 16

Locust bean gum 9000-40-2 44 16

Lomustine 13010-47-4 48 17

1020 Long Multiwalled Carbon

Nanotube

L-MWNT-1020 34 13

1020 Long Multiwalled Carbon

Nanotube

L-MWNT-1020 32 4

@ Low isoflavone soy protein powder

(Prevention 6)

(Listed As: Prevention 6

(low isoflavone soy protein

powder))

ISOFLAVSOYPT 52 *

@ Luperox TBH70

(Listed As: tert-Butyl

hydroperoxide)

75-91-2 50 *

@ Luperox TBH70

(Listed As: tert-Butyl

hydroperoxide)

75-91-2 50 *

Magnetic fields (EMF) ELECTROMAG 44 16

Magnetic fields (EMF) ELECTROMAG 51 *

Magnetic fields (EMF) ELECTROMAG 37 16

Magnetic fields + DMBA initiation

promotion

EMF+DMBA 37 16

Malachite green 569-64-2 44 16

Malachite green 569-64-2 37 16

Malaoxon 1634-78-2 44 16

Malathion 121-75-5 44 16

Malathion 121-75-5 44 16

@ Melatonin + silymarin (Prevention

2)

(Listed As: Prevention 2

(Silymarin + melatonin))

SILYMARN+MEL 52 *

Malonaldehyde, sodium salt 24382-04-5 44 16

@ MAN

(Listed As: Methacrylonitrile)

126-98-7 16

@ MAN

(Listed As: Methacrylonitrile)

126-98-7 44 16

Manganese sulfate monohydrate 10034-96-5 38 16

Manganese sulfate monohydrate 10034-96-5 44 16

D-Mannitol 69-65-8 44 16

@ Marijuana component

(Listed As: 1-trans-delta-9-

Tetrahydrocannabinol)

1972-08-3 38 16

@ Marijuana component

(Listed As: 1-trans-delta-9-

Tetrahydrocannabinol)

1972-08-3 46 16

Melamine 108-78-1 44 16

Melamine + Cyanuric Acid

combination

MELCYANCOMB 32 5

Melamine + Cyanuric Acid

combination

MELCYANCOMB 51 *

Melatonin 73-31-4 51 *

Melatonin 73-31-4 51 *

@ Melatonin + curcumin (Prevention

4)

(Listed As: Prevention 4

(Melatonin + curcumin))

MEL+CURCUMIN 52 *
Last Update: 09/18/2015 10:46 Management Status Report Page 20

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ Melatonin + indole-3-carbinol

(Prevention 4)

(Listed As: Prevention

4 (Melatonin + indole-3-

carbinol))

MEL+INDOLCAR 52 *

@ Melatonin (Prevention 2)

(Listed As: Prevention 2

(Melatonin))

73-31-4 52 *

@ Melatonin (Prevention 3)

(Listed As: Prevention 3

(Melatonin))

73-31-4 52 *

Melphalan 148-82-3 48 17

@ Melphalan (Transgenic model

evaluation)

(Listed As: Transgenic model

evaluation (Melphalan))

148-82-3 54 *

@ Melphalan (Transgenic model

evaluation)

(Listed As: Transgenic model

evaluation (Melphalan))

148-82-3 54 *

@ Melphalan (Transgenic model

evaluation)

(Listed As: Transgenic model

evaluation (Melphalan))

148-82-3 54 *

@ Melphalan (Transgenic model

evaluation)

(Listed As: Transgenic model

evaluation (Melphalan))

148-82-3 54 *

@ Melphalan (Transgenic model

evaluation)

(Listed As: Transgenic model

evaluation (Melphalan))

148-82-3 54 *

DL-menthol 15356-70-4 44 16

2-Mercaptobenzimidazole 583-39-1 51 *

2-Mercaptobenzimidazole 583-39-1 51 *

2-Mercaptobenzothiazole 149-30-4 44 16

6-Mercaptopurine 50-44-2 48 17

Mercuric chloride 7487-94-7 44 16

Merphalan 531-76-0 48 17

Metal working fluids (Syntilo

1023)

SYNTILO1023 51 *

Metal Working Fluids: CIMSTAR

3800

CIMSTAR3800 34 14

Metal working fluids (Trim SC210) TRIMSC210 52 *

Metal Working Fluids: Trim VX TRIMVX 34 13

Methacrylonitrile 126-98-7 16

Methacrylonitrile 126-98-7 44 16

Methapyrilene hydrochloride 135-23-9 48 17

Methapyrilene hydrochloride 135-23-9 52 *

Methapyrilene hydrochloride 135-23-9 37 16

Methdilazine 1982-37-2 52 *

@ N-methololacrylamide (Transgenic

model evaluation)

(Listed As: Transgenic

model evaluation (NMethylolacrylamide))

924-42-5 54 *

@ N-methololacrylamide (Transgenic

model evaluation)

(Listed As: Transgenic

model evaluation (NMethylolacrylamide))

924-42-5 54 *

Methotrexate 59-05-2 48 17

6-Methoxy-2-benzothiazolamine 1747-60-0 52 *

Methoxychlor 72-43-5 44 16

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ Methoxyethanol

(Listed As: NTP-88 diet study

(EGMME))

DIET88+EGMME 52 *

2-Methoxy-4-nitroaniline 97-52-9 52 *

8-Methoxypsoralen 298-81-7 44 16

4-(6-Methyl-2-benzothiazolyl)-

benzenamine

92-36-4 52 *

alpha-Methylbenzyl alcohol 98-85-1 44 16

Methyl bromide 74-83-9 38 16

Methyl bromide 74-83-9 44 16

Methyl bromide 74-83-9 38 16

Methyl carbamate 598-55-0 44 16

Methyl CCNU 13909-09-6 48 17

@ Methyl chloroform

(Listed As: 1,1,1-

Trichloroethane)

71-55-6 47 16

@ Methyl chloroform

(Listed As: 1,1,1-

Trichloroethane)

71-55-6 37 16

Methyl coumarin 92-48-8 52 *

4-Methylcyclohexanemethanol 34885-03-5 32 5

Methyldopa sesquihydrate 41372-08-1 44 16

4,4'-Methylenebis(N,Ndimethyl)benzenamine101-61-1 44 16

Methylene bis(thiocyanate) 6317-18-6 37 16

Methylene blue trihydrate 7220-79-3 52 *

Methylene blue trihydrate 7220-79-3 52 *

Methylene blue trihydrate 7220-79-3 44 16

Methylene chloride 75-09-2 44 16

4,4'-Methylenedianiline

dihydrochloride

13552-44-8 44 16

Methyl ethyl ketone peroxide 1338-23-4 37 16

Methyl ethyl ketoxime 96-29-7 37 16

Methyleugenol 93-15-2 38 16

Methyleugenol 93-15-2 44 16

Methyleugenol (TGMX rat liver

evaluation)

93-15-2 52 *

2-Methylimidazole 693-98-1 37 16

2-Methylimidazole 693-98-1 44 16

4-Methylimidazole 822-36-6 37 16

4-Methylimidazole 822-36-6 44 16

Methyl isobutyl ketone 108-10-1 44 16

Methyl isocyanate 624-83-9 48 17

6-Methylmercaptopurine

ribonucleoside

342-69-8 48 17

Methyl methacrylate 80-62-6 44 16

3-Methyl-6-methoxy-2-aminobenzothiazolium chlorideEMTDP-76 52 *

3-Methyl-6-methoxy-2-aminobenzothiazolium chlorideEMTDP-76 52 *

2-Methyl-1-nitroanthraquinone 129-15-7 44 16

2-Methyl-1-nitroanthraquinone 129-15-7 48 17

@ 1-BUTANONE, 4-

(METHYLNITROSOAMINO)-1-3-

PYRIDINYL)- (9CI)

(Listed As: Ozone/NNK)

OZONNNKCOMB 45 16

N-Methylolacrylamide 924-42-5 44 16

Methyl parathion 298-00-0 44 16

Methylphenidate hydrochloride 298-59-9 38 16
Last Update: 09/18/2015 10:46 Management Status Report Page 21

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Methylphenidate hydrochloride 298-59-9 44 16

@ Methylphenidate hydrochloride

(Transgenic model evaluation)

(Listed As: Transgenic model

evaluation (Methylphenidate

hydrochloride))

298-59-9 54 *

alpha-Methylstyrene 98-83-9 52 *

alpha-Methylstyrene 98-83-9 44 16

Methyl trans-styryl ketone 1896-62-4 52 *

Methyl trans-styryl ketone 1896-62-4 52 *

Methyl trans-styryl ketone 1896-62-4 44 16

Methyl vinyl ketone 78-94-4 52 *

@ N-Methyl-N'-nitro-Nnitrosoguanidine (MNNG)

(Listed As: Init/prom

comparative mouse study (DMBA/

TPA/BPO/MNNG))

INIT/PROM 43 16

@ N-Methyl-N'-nitro-Nnitrosoguanidine (MNNG)

(Listed As: Init/prom

comparative mouse study (DMBA/

TPA/BPO/MNNG))

INIT/PROM 43 16

@ N-Methyl-N'-nitro-Nnitrosoguanidine (MNNG)

(Listed As: Init/prom

comparative mouse study (DMBA/

TPA/BPO/MNNG))

INIT/PROM 43 16

Mexacarbate 315-18-4 44 16

Michler's ketone 90-94-8 44 16

Microcystin-LA (TGMX) 96180-79-9 52 *

Microcystin-LR (TGMX) 101043-37-2 52 *

Microcystin mixture (TGMX) MICROCYSTNMX 52 *

Milk thistle extract 84604-20-6 44 16

Mirex 2385-85-5 44 16

Mitomycin C 50-07-7 48 17

Molybdenum trioxide 1313-27-5 38 16

Molybdenum trioxide 1313-27-5 44 16

Monochloroacetic acid 79-11-8 44 16

Monuron 150-68-5 44 16

@ 8-MOP

(Listed As: 8-Methoxypsoralen)

298-81-7 44 16

Mouse ageing study MOUSEAGE 48 17

@ MVK

(Listed As: Methyl vinyl

ketone)

78-94-4 52 *

@ MX

(Listed As: 3-Chloro-4-

(dichloromethyl)-5-hydroxy2(5H)-furanone(MX))

77439-76-0 50 *

beta-Myrcene 123-35-3 44 16

Myristicin 607-91-0 52 *

Nalidixic acid 389-08-2 44 16

Nanoscale Material (Fullerene C60

18 microns)

99685-96-8 31 3

Nanoscale material (Fullerene-C60

1 micron)

99685-96-8 34 12

Nanoscale Material (Fullerene C60

200 nanometers)

99685-96-8 31 3

Nanoscale material (Fullerene-C60

50 nanometers)

99685-96-8 34 12

Nanoscale material (Quantum dots) QUANTUMDOTS 52 *

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Nanoscale material (Rutile

titanium dioxide)

1317-80-2 52 *

Nanoscale Silver 7440-22-4 32 5

Naphthalene 91-20-3 44 16

Naphthalene 91-20-3 44 16

1,5-Naphthalenediamine 2243-62-1 44 16

N-(1-Naphthyl)ethylenediamine

dihydrochloride

1465-25-4 44 16

Navy fuels JP-5 8008-20-6 44 16

@ NBBS

(Listed As: NButylbenzenesulfonamide)

3622-84-2 32 5

@ NBPC

(Listed As: Ionic Liquid: NButylpyridinium Chloride)

1124-64-7 32 5

NCT/DERT standardization

experiment (APAP & AMAP)

NCTSTANDARD 52 *

@ Nevirex (R)

(Listed As: Acetochlor)

34256-82-1 49 *

Nickel (II) oxide 1313-99-1 44 16

Nickel sulfate hexahydrate 10101-97-0 44 16

Nickel subsulfide 12035-72-2 44 16

Nithiazide 139-94-6 44 16

Nitrilotriacetic acid (NTA) 139-13-9 44 16

Nitrilotriacetic acid trisodium

monohydrate

18662-53-8 44 16

Nitrilotriacetic acid trisodium

monohydrate

18662-53-8 44 16

5-Nitroacenaphthene 602-87-9 44 16

3-Nitro-p-acetophenetide 1777-84-0 44 16

p-Nitroaniline 100-01-6 38 16

p-Nitroaniline 100-01-6 44 16

5-Nitro-o-anisidine 99-59-2 44 16

o-Nitroanisole 91-23-6 38 16

o-Nitroanisole 91-23-6 44 16

4-Nitroanthranilic acid 619-17-0 44 16

Nitrobenzene 98-95-3 52 *

6-Nitrobenzimidazole 94-52-0 44 16

m-Nitrobenzoic acid 121-92-6 52 *

p-Nitrobenzoic acid 62-23-7 38 16

p-Nitrobenzoic acid 62-23-7 44 16

Nitrofen 1836-75-5 44 16

Nitrofen 1836-75-5 44 16

Nitrofurantoin 67-20-9 44 16

Nitrofurazone 59-87-0 45 16

Nitrofurazone 59-87-0 49 17

Nitromethane 75-52-5 45 16

1-Nitronaphthalene 86-57-7 45 16

p-Nitrophenol 100-02-7 45 16

2-Nitro-p-phenylenediamine 5307-14-2 45 16

4-Nitro-o-phenylenediamine 99-56-9 45 16

5-(4-Nitrophenyl)-2,4-pentadien1-al (NPPD)2608-48-2 52 *

5-(4-Nitrophenyl)-2,4-pentadien1-al (NPPD)2608-48-2 52 *

3-Nitropropionic acid 504-88-1 45 16

1-Nitropyrene 5522-43-0 37 16

N-Nitrosodiethanolamine 1116-54-7 49 17
Last Update: 09/18/2015 10:46 Management Status Report Page 22

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

N-Nitrosodimethylamine (TGMX rat

liver evaluation)

62-75-9 52 *

N-Nitrosodiphenylamine 86-30-6 45 16

p-Nitrosodiphenylamine 156-10-5 45 16

beta-Nitrostyrene 102-96-5 45 16

m-Nitrotoluene 99-08-1 37 16

o-Nitrotoluene 88-72-2 37 16

o-Nitrotoluene 88-72-2 37 16

o-Nitrotoluene 88-72-2 45 16

p-Nitrotoluene 99-99-0 52 *

p-Nitrotoluene 99-99-0 37 16

p-Nitrotoluene 99-99-0 45 16

5-Nitro-o-toluidine 99-55-8 45 16

@ NNK

(Listed As: Ozone/NNK)

OZONNNKCOMB 45 16

@ NTA

(Listed As: Nitrilotriacetic

acid (NTA))

139-13-9 44 16

NTP-2000 diet DIET2000 52 *

NTP 90 diet study DIET90 49 17

NTP 91/92 diet study DIET9192 49 17

NTP-88 diet study (EGMBE) DIET88+EGMBE 52 *

NTP-88 diet study (EGMEE) DIET88+EGMEE 52 *

NTP-88 diet study (EGMME) DIET88+EGMME 52 *

NTP-88 diet study

(m-Nitrotoluene)

DIET88+MNITR 52 *

NTP-88 diet study

(o-Nitrotoluene)

DIET88+ONITR 52 *

NTP-88 diet study

(p-Nitrotoluene)

DIET88+PNITR 52 *

Ochratoxin A 303-47-9 45 16

Phenolic Benzotriazoles

(Octrizole)

3147-75-9 32 4

Oleic acid diethanolamine

condensate

93-83-4 45 16

@ Oleic acid diethanolamine

condensate (transgenic LECM)

(Listed As: Transgenic LECM

(Oleic acid diethanolamine

condensate))

93-83-4 53 *

@ Oleic acid diethanolamine

condensate (transgenic LECM)

(Listed As: Transgenic LECM

(Oleic acid diethanolamine

condensate))

93-83-4 53 *

@ Orange 10, C.I.Acid

(Listed As: C.I. Acid Orange

10)

1936-15-8 41 16

@ Orange 3, C.I. Acid

(Listed As: C.I. Acid Orange

3)

6373-74-6 41 16

Oxazepam 604-75-1 45 16

Oxazepam 604-75-1 45 16

4,4'-Oxydianiline 101-80-4 45 16

Oxymetholone 434-07-1 52 *

Oxymetholone 434-07-1 45 16

Oxytetracycline hydrochloride 2058-46-0 45 16

Ozone 10028-15-6 45 16

Ozone 10028-15-6 45 16

Ozone/NNK OZONNNKCOMB 45 16

Parathion 56-38-2 45 16

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ 2,5-PCADPE

(Listed As: 2,5-

Pyridinedicarboxylic Acid,

Dipropyl Ester)

136-45-8 52 *

@ PCB 126/PECDF mixture (TEF

transgenics)

(Listed As: TEF transgenics

(PCB 126 / PECDF mixture))

TEFTGMIXTURE 53 *

@ PCB 126 (TEF transgenics)

(Listed As: TEF transgenics

(PCB 126))

57465-28-8 53 *

@ PCB 126 (Toxic equivalency factor

evaluation)

(Listed As: Toxic equivalency

factor evaluation

((PCB 126) 3,3',4,4',5-

pentachlorobiphenyl))

57465-28-8 47 16

@ PCB 153 (Toxic equivalency factor

evaluation)

(Listed As: Toxic equivalency

factor evaluation (PCB

153- 2,2'-4,4',5,5'-

hexachlorobiphenyl))

35065-27-1 47 16

@ PCBTF

(Listed As: p-Chloro-a,a,atrifluorotoluene)

98-56-6 50 *

@ PCBTF

(Listed As: p-Chloro-a,a,atrifluorotoluene)

98-56-6 33 10

@ PCBTF

(Listed As: p-Chloro-a,a,atrifluorotoluene)

98-56-6 36 16

@ PCBTF

(Listed As: p-Chloro-a,a,atrifluorotoluene)

98-56-6 36 16

@ PCB-118 (Toxic equivalency factor

evaluation)

(Listed As: Toxic equivalency

factor evaluation (PCB 118))

31508-00-6 46 16

PCN 66/67 comparison study PCNCOMPARISN 34 14

@ PCTFT

(Listed As: p-Chloro-a,a,atrifluorotoluene)

98-56-6 50 *

@ PCTFT

(Listed As: p-Chloro-a,a,atrifluorotoluene)

98-56-6 33 10

@ PCTFT

(Listed As: p-Chloro-a,a,atrifluorotoluene)

98-56-6 36 16

@ PCTFT

(Listed As: p-Chloro-a,a,atrifluorotoluene)

98-56-6 36 16

@ PECDF (TEF transgenics)

(Listed As: TEF transgenics

(PECDF))

57117-31-4 53 *

Penicillin VK 132-98-9 45 16

2,2',4,4',5-Pentabromodiphenyl

Ether

60348-60-9 31 2

Pentabromodiphenyl Oxide

(Technical) (DE 71)

32534-81-9 34 13

Pentabromodiphenyl Oxide

(Technical) (DE 71)

32534-81-9 31 3

Pentabromodiphenyl Oxide

(Technical) (DE 71)

32534-81-9 31 2

Pentabromodiphenyl Oxide

(Technical) (DE 71)

32534-81-9 32 5

Pentabromodiphenyl Oxide

(Technical) (DE 71)

32534-81-9 32 4
Last Update: 09/18/2015 10:46 Management Status Report Page 23

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ Pentabromoethane (Halogenated

ethanes CS)

(Listed As: Halogenated

ethanes CS (Pentabromoethane))

75-95-6 36 16

Pentachloroanisole 1825-21-4 45 16

Pentachlorobenzene 608-93-5 37 16

3,3,4,4,5-Pentachlorobiphenyl

(PCB 126)

57465-28-8 32 4

@ Pentachlorodibenzofuran (Toxic

equivalency factor evaluation)

(Listed As: Toxic equivalency

factor evaluation (PECDF

(Pentachlorodibenzofuran)))

57117-31-4 46 16

Pentachloroethane 76-01-7 45 16

@ Pentachloroethane (Halogenated

ethanes CS)

(Listed As:

Halogenated ethanes CS

(Pentachloroethane))

76-01-7 36 16

Pentachloronitrobenzene 82-68-8 45 16

Pentachloronitrobenzene 82-68-8 45 16

Pentachlorophenol, Dowicide EC-7 87-86-5 45 16

Pentachlorophenol, DP-2 87-86-5 38 16

Pentachlorophenol, purified 87-86-5 38 16

Pentachlorophenol, purified 87-86-5 45 16

Pentachlorophenol, technical 87-86-5 45 16

@ Pentachlorophenol (Transgenic

LECM)

(Listed As: Transgenic LECM

(Pentachlorophenol))

87-86-5 53 *

@ Pentachlorophenol (Transgenic

LECM)

(Listed As: Transgenic LECM

(Pentachlorophenol))

87-86-5 53 *

Pentaerythritol tetranitrate 78-11-5 45 16

Pentaerythritol triacrylate 3524-68-3 35 16

Pentaerythritol triacrylate 3524-68-3 35 16

2,3-Pentanedione 600-14-6 34 12

@ Perchloroethylene

(Listed As:

Tetrachloroethylene)

127-18-4 46 16

@ Perchloroethylene

(Listed As:

Tetrachloroethylene)

127-18-4 46 16

Perfluorobutane sulfonate (PFBS) 375-73-5 33 6

Perfluorodecanoic Acid 335-76-2 33 6

Perfluorohexane sulfonate

potassium salt (PFHSKslt)

3871-99-6 32 5

Perfluorohexanoic acid (PFHXA) 307-24-4 33 6

Perfluorononanoic Acid 375-95-1 33 6

Perfluorooctane Sulfonate 1763-23-1 33 6

Perfluorooctanoic Acid 335-67-1 33 10

Perfluorooctanoic Acid 335-67-1 33 10

Perfluorooctanoic Acid 335-67-1 52 *

Perfluorooctanoic Acid 335-67-1 33 6

Peroxisome project (Dibutyl

phthalate)

84-74-2 52 *

Peroxisome project

(2,4-Dichlorophenoxyacetic acid)

94-75-7 52 *

Peroxisome project (Gemfibrozil) 25812-30-0 52 *

Peroxisome project (WY-14643) 50892-23-4 37 16

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Pesticide/fertilizer

contamination--mixture 2

PESTFERTMIX2 37 16

Pesticide/fertilizer

contamination--mixture 3

PESTFERTMIX3 37 16

@ PETA

(Listed As: Pentaerythritol

triacrylate)

3524-68-3 35 16

@ PETA

(Listed As: Pentaerythritol

triacrylate)

3524-68-3 35 16

@ PFDA

(Listed As: Perfluorodecanoic

Acid)

335-76-2 33 6

@ PFNA

(Listed As: Perfluorononanoic

Acid)

375-95-1 33 6

@ PGTBE

(Listed As: Propylene glycol

mono-t-butyl ether)

57018-52-7 45 16

Phenazopyridine hydrochloride 136-40-3 45 16

Phenesterin 3546-10-9 45 16

Phenformin hydrochloride 834-28-6 45 16

Phenobarbital 50-06-6 32 5

Phenol 108-95-2 45 16

Phenolic Benzotriazoles

(2-(2H-Benzotriazol-2-yl)phenol)

10096-91-0 32 4

Phenolic Benzotriazoles (Phenol,

2-(2H-benzotriazol-2-yl)-4,6-

bis(1,1-dimethylpropyl)-)

25973-55-1 32 4

Phenolic Benzotriazoles (Phenol,

2-(2H-benzotriazol-2-yl)-4,6-

bis(1-methyl-1-phenylethyl)-)

70321-86-7 32 4

Phenolic Benzotriazoles (2-(5-

Chloro-2Hbenzotriazol-2-yl)-

4,6bis(1,1 dimethylethyl)phenol)

3864-99-1 32 4

Phenolic Benzotriazoles

(Bumetrizole)

3896-11-5 32 4

Phenolphthalein 77-09-8 38 16

Phenolphthalein 77-09-8 45 16

@ Phenolphthalein (Transgenic model

evaluation)

(Listed As: Transgenic model

evaluation (Phenolphthalein))

77-09-8 54 *

@ Phenolphthalein (Transgenic model

evaluation II)

(Listed As: Transgenic

model evaluation II

(Phenolphthalein))

77-09-8 35 16

Phenoxybenzamine hydrochloride 63-92-3 45 16

Phenylbutazone 50-33-9 45 16

p-Phenylenediamine

dihydrochloride

624-18-0 45 16

Phenylephrine hydrochloride 61-76-7 45 16

1-Phenyl-3-methyl-5-pyrazolone 89-25-8 45 16

N-Phenyl-2-naphthylamine 135-88-6 45 16

o-Phenylphenol 90-43-7 45 16

N-Phenyl-p-phenylenediamine 101-54-2 45 16

1-Phenyl-2-thiourea 103-85-5 45 16

@ Phenytoin

(Listed As: 5,5-

Diphenylhydantoin (phenytoin))

57-41-0 42 16

@ Phorbol myristate acetate

(Listed As: Tetradecanoyl

phorbol acetate (TPA))

16561-29-8 53 *
Last Update: 09/18/2015 10:46 Management Status Report Page 24

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Phosphamidon 13171-21-6 45 16

Phosphine 7803-51-2 52 *

Photodieldrin 13366-73-9 45 16

ortho-Phthalaldehyde 643-79-8 34 12

Phthalamide 88-96-0 45 16

Phthalic anhydride 85-44-9 45 16

Picloram 1918-02-1 45 16

beta-Picoline 108-99-6 45 16

Piperonyl butoxide 51-03-6 45 16

Piperonyl sulfoxide 120-62-7 45 16

Pivalolactone 1955-45-9 45 16

Polybrominated biphenyl mixture

(Firemaster FF-1)

67774-32-7 45 16

Polybrominated biphenyl mixture

(Firemaster FF-1)

67774-32-7 45 16

Polysorbate 80 (glycol) 9005-65-6 45 16

Polyurethane 9009-54-5 49 17

Polyvinyl alcohol 9002-89-5 45 16

Prednisone 53-03-2 49 17

Pregnancy Rate Comparison Study PREGRATECOMP 52 *

Prevention 1 (Melatonin) 73-31-4 52 *

Prevention 2 (Melatonin) 73-31-4 52 *

Prevention 2 (Silymarin) 65666-07-1 52 *

Prevention 2 (Silymarin +

melatonin)

SILYMARN+MEL 52 *

Prevention 3 (Melatonin) 73-31-4 52 *

Prevention 6 (low isoflavone soy

protein powder)

ISOFLAVSOYPT 52 *

Prevention 4 (Curcumin) 458-37-7 52 *

Prevention 7 (feed controls) PREVENTION7 52 *

Prevention 1 (Flaxseed oil) 8001-26-1 52 *

Prevention 1 (Flaxseed oil +

melatonin)

FLAXSEED+MEL 52 *

Prevention 4 (Indole-3-carbinol) 700-06-1 52 *

Prevention 6 (isoflavone

concentrate)

ISOFLAVCONCN 52 *

Prevention 4 (Melatonin) 73-31-4 52 *

Prevention 5 (Melatonin) 73-31-4 52 *

Prevention 4 (Melatonin +

curcumin)

MEL+CURCUMIN 52 *

Prevention 4 (Melatonin +

indole-3-carbinol)

MEL+INDOLCAR 52 *

Prevention 10 (Soy isoflavone

concentrate)

PREVENTION10 52 *

Primidone (primaclone) 125-33-7 45 16

Probenecid 57-66-9 45 16

Procarbazine hydrochloride 366-70-1 49 17

Procarbazine hydrochloride 366-70-1 45 16

Proflavin hydrochloride 952-23-8 45 16

Promethazine hydrochloride 58-33-3 38 16

Promethazine hydrochloride 58-33-3 45 16

Propantheline bromide 50-34-0 52 *

Propargyl alcohol 107-19-7 45 16

Propylene 115-07-1 45 16

@ Propylene dichloride

(Listed As: 1,2-

Dichloropropane (propylene

dichloride))

78-87-5 41 16

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Propylene glycol mono-t-butyl

ether

57018-52-7 45 16

Propylene glycol phenyl ether 770-35-4 32 5

1,2-Propylene oxide 75-56-9 45 16

Propyl gallate 121-79-9 46 16

Propyl-4-hydroxybenzoate 94-13-3 31 2

Pulegone 89-82-7 46 16

Pyrazinamide 98-96-4 46 16

Pyridine 110-86-1 32 5

Pyridine 110-86-1 46 16

Pyridine 110-86-1 46 16

2,5-Pyridinedicarboxylic Acid,

Dipropyl Ester

136-45-8 52 *

@ Pyridine (Transgenic LECM)

(Listed As: Transgenic LECM

(Pyridine))

110-86-1 53 *

@ Pyridine (Transgenic LECM)

(Listed As: Transgenic LECM

(Pyridine))

110-86-1 53 *

Pyrilamine 91-84-9 46 16

Pyrimethamine 58-14-0 46 16

Pyrogallol 87-66-1 46 16

QT drugs (bepridil hydrochloride) 74764-40-2 52 *

QT drugs (diltiazem

hydrochloride)

33286-22-5 52 *

QT drugs (Loratadine) 79794-75-5 53 *

QT drugs (Lovastatin) 75330-75-5 53 *

QT drugs (sotalol hydrochloride) 959-24-0 53 *

QT drugs (terfenadine) 50679-08-8 53 *

Quercetin 117-39-5 46 16

Rat feed study (TGMX rat liver

evaluation)

TGMXRALVFEED 53 *

@ Red 114, C.I. Acid

(Listed As: C.I. Acid Red 114)

6459-94-5 41 16

@ Red 14, C.I. Acid

(Listed As: C.I. Acid Red 14)

3567-69-9 41 16

@ Red 9, C.I. Acid

(Listed As: C.I. Basic Red 9

Monohydrochloride)

569-61-9 41 16

@ Red 23, C.I. Pigment

(Listed As: C.I. Pigment Red

23)

6471-49-4 41 16

@ Red 3, C.I. Pigment

(Listed As: C.I. Pigment Red

3)

2425-85-6 41 16

@ Red Dog Mine Ore (Alaska)

(Listed As: Lead ores)

LEADORES 51 *

@ Red 3, HC

(Listed As: HC Red 3)

2871-01-4 43 16

@ Red No. 9, D&C

(Listed As: D&C Red No. 9)

5160-02-1 41 16

Reserpine 50-55-5 46 16

Reserpine 50-55-5 53 *

Resorcinol 108-46-3 46 16

@ Resorcinol (Transgenic model

evaluation)

(Listed As: Transgenic model

evaluation (Resorcinol))

108-46-3 54 *

@ Resorcinol (Transgenic model

evaluation)

(Listed As: Transgenic model

evaluation (Resorcinol))

108-46-3 54 *
Last Update: 09/18/2015 10:46 Management Status Report Page 25

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Resveratrol 501-36-0 33 8

Retinoid project 2

(4-(Hydroxyphenyl)retinamide)

65646-68-6 53 *

Retinoid project 1 RETINOID1 53 *

Retinoid project 3 (Retinol

acetate)

127-47-9 53 *

Retinoid project 4

(4-(Hydroxyphenyl)retinamide)

65646-68-6 53 *

Retinoid project 5

(4-(Hydroxyphenyl)retinamide)

65646-68-6 53 *

Retinoid project 6 (Arotinoid) 125533-88-2 53 *

Retinoid project 3 (Arotinoid) 125533-88-2 53 *

Retinoid project 5 (Arotinoid) 125533-88-2 53 *

Retinoid project 6 (4-HPR) 65646-68-6 53 *

All-trans-retinyl palmitate 79-81-2 46 16

Retroviral vectors RETROVIRVECT 53 *

Retroviral vectors RETROVIRVECT 53 *

Retroviral vectors RETROVIRVECT 53 *

Retroviral vectors RETROVIRVECT 53 *

Rhodamine 6G 989-38-8 46 16

@ Rhothane (TDE)

(Listed As:

Tetrachlorodiphenylethane)

72-54-8 46 16

Riddelliine 23246-96-0 37 16

Riddelliine 23246-96-0 46 16

@ Ritalin hydrochloride

(Listed As: Methylphenidate

hydrochloride)

298-59-9 38 16

@ Ritalin hydrochloride

(Listed As: Methylphenidate

hydrochloride)

298-59-9 44 16

Rotenone 83-79-4 49 17

Rotenone 83-79-4 46 16

@ Rotenone (Transgenic model

evaluation)

(Listed As: Transgenic model

evaluation (Rotenone))

83-79-4 54 *

@ Rotenone (Transgenic model

evaluation)

(Listed As: Transgenic model

evaluation (Rotenone))

83-79-4 54 *

@ Roundup®

(Listed As: Glyphosate)

1071-83-6 36 16

@ Roundup®

(Listed As: Glyphosate)

1071-83-6 36 16

Roxarsone 121-19-7 46 16

Safflower oil 8001-23-8 46 16

Salicylazosulfapyridine 599-79-1 38 16

Salicylazosulfapyridine 599-79-1 46 16

@ Salicylic acid (alpha/beta

Hydroxy acids)

(Listed As: alpha/beta

Hydroxy acids (glycolic acid,

salicylic acid))

HYDROXGLYSAL 39 16

Scopolamine hydrobromide

trihydrate

6533-68-2 38 16

Scopolamine hydrobromide

trihydrate

6533-68-2 53 *

Scopolamine hydrobromide

trihydrate

6533-68-2 46 16

@ Selenate, Sodium

(Listed As: Sodium selenate)

13410-01-0 37 16

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ Selenite, Sodium

(Listed As: Sodium selenite)

10102-18-8 37 16

Selenium sulfide 7446-34-6 46 16

Selenium sulfide 7446-34-6 46 16

Selsun EMTDP-74 46 16

Senna (powdered) 8013-11-4 37 16

Senna (powdered) 8013-11-4 37 16

Serotype 5 Adeno-associated Viral

Vector (rAAV5SCTLA4:Ig)

RAV5SCTLA4IG 34 14

Serotype 2 Adeno-associated Viral

Vector rAAV2rapahEpo

AAVIRAAVHEPO 34 14

Serotype 2 Adeno-associated Viral

Vector hAQP1 (rAAV2hAQP1)

AAV2HAQP1 34 12

Silica, crystalline - quartz 14808-60-7 53 *

Silica, crystalline - quartz 14808-60-7 53 *

Silica, crystalline - quartz 14808-60-7 53 *

@ Silymarin + melatonin (Prevention

2)

(Listed As: Prevention 2

(Silymarin + melatonin))

SILYMARN+MEL 52 *

@ SILYMARIN (PREVENTION 2)

(Listed As: Prevention 2

(Silymarin))

65666-07-1 52 *

Simazine 122-34-9 53 *

Sodium azide 26628-22-8 46 16

@ Sodium bromate (Water

disinfection mode)

(Listed As: Water disinfection

model (Sodium bromate))

7789-38-0 35 16

@ Sodium bromate (Water

disinfection mode)

(Listed As: Water disinfection

model (Sodium bromate))

7789-38-0 35 16

@ Sodium bromate (Water

disinfection mode)

(Listed As: Water disinfection

model (Sodium bromate))

7789-38-0 35 16

@ Sodium chlorate (Water

disinfection byproducts)

(Listed As: Water disinfection

byproducts (Sodium chlorate))

7775-09-9 47 16

Sodium cyanide 143-33-9 16

Sodium dichromate dihydrate (VI) 7789-12-0 46 16

Sodium dichromate dihydrate (VI) 7789-12-0 37 16

Sodium diethyldithiocarbamate 148-18-5 46 16

Sodium Fluoride 7681-49-4 46 16

Sodium Fluoride 7681-49-4 49 17

Sodium Metavanadate 13718-26-8 32 5

Sodium Metavanadate 13718-26-8 31 2

Sodium nitrite 7632-00-0 38 16

Sodium nitrite 7632-00-0 46 16

Sodium selenate 13410-01-0 37 16

Sodium selenite 10102-18-8 37 16

Sodium thioglycolate 367-51-1 34 14

Sodium Tungstate Dihydrate 10213-10-2 33 8

Sodium xylenesulfonate 1300-72-7 38 16

Sodium xylenesulfonate 1300-72-7 46 16

@ Spy Dust

(Listed As: 5-(4-Nitrophenyl)-

2,4-pentadien-1-al (NPPD))

2608-48-2 52 *
Last Update: 09/18/2015 10:46 Management Status Report Page 26

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ Spy Dust

(Listed As: 5-(4-Nitrophenyl)-

2,4-pentadien-1-al (NPPD))

2608-48-2 52 *

Stannous chloride 7772-99-8 46 16

Stoddard solvent (type lIC) 64742-88-7 46 16

Streptozotocin 18883-66-4 49 17

Styrene 100-42-5 46 16

Styrene 100-42-5 53 *

Styrene-acrylonitrile trimer SANTRIMER2 46 16

Styrene oxide 96-09-3 49 17

Succinic anhydride 108-30-5 46 16

Sulfallate 95-06-7 46 16

Sulfamethazine 57-68-1 46 16

Sulfamethazine 57-68-1 46 16

Sulfisoxazole 127-69-5 46 16

Sulfolane 126-33-0 33 6

Sulfolane 126-33-0 33 7

3-Sulfolene 77-79-2 46 16

4,4'-Sulfonyldianiline (Dapsone) 80-08-0 46 16

@ Sunett

(Listed As: Transgenic Model

Evaluation II (Acesulfame

Potassium))

55589-62-3 35 16

Talc 14807-96-6 46 16

Tara gum 39300-88-4 46 16

@ TBA

(Listed As: tert-Butyl

alcohol)

75-65-0 40 16

@ TBA

(Listed As: tert-Butyl

alcohol)

75-65-0 36 16

@ TBBC

(Listed As: 4,4-Thiobis(6-

tert-butyl-m-cresol))

96-69-5 53 *

@ TBBC

(Listed As: 4,4-Thiobis(6-

tert-butyl-m-cresol))

96-69-5 47 16

@ TBDP

(Listed As: tert-Butylphenyl

Diphenyl Phosphate)

56803-37-3 50 *

@ TBDP

(Listed As: tert-Butylphenyl

Diphenyl Phosphate)

56803-37-3 31 2

@ TBE

(Listed As: Halogenated

ethanes CS (1,1,2,2-

Tetrabromoethane))

79-27-6 37 16

@ TCAB

(Listed As: 3,3',4,4'-

Tetrachloroazobenzene)

14047-09-7 53 *

@ TCAB

(Listed As: 3,3',4,4'-

Tetrachloroazobenzene)

14047-09-7 37 16

@ TCAB

(Listed As: 3,3',4,4'-

Tetrachloroazobenzene)

14047-09-7 37 16

@ TCAB

(Listed As: 3,3',4,4'-

Tetrachloroazobenzene)

14047-09-7 46 16

@ TCAOB

(Listed As: 3,3',4,4'-

Tetrachloroazoxybenzene)

21232-47-3 37 16

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ TCDD

(Listed As: Transgenic

Model Evaluation (2,3,7,8-

Tetrachlorodibenzodioxin))

1746-01-6 54 *

@ TCDD

(Listed As: Transgenic

Model Evaluation (2,3,7,8-

Tetrachlorodibenzodioxin))

1746-01-6 54 *

@ TCDD

(Listed As: Transgenic

Model Evaluation (2,3,7,8-

Tetrachlorodibenzodioxin))

1746-01-6 54 *

@ TCDD

(Listed As: Transgenic

Model Evaluation (2,3,7,8-

Tetrachlorodibenzodioxin))

1746-01-6 54 *

@ TCDD (TEF transgenics)

(Listed As: TEF transgenics

(TCDD))

1746-01-6 53 *

@ TCDD (Toxic equivalency factor

evaluation)

(Listed As: Toxic equivalency

factor evaluation (TCDD))

1746-01-6 46 16

@ TCP

(Listed As: Tricresyl

Phosphate)

1330-78-5 54 *

@ TCP

(Listed As: Tricresyl

Phosphate)

1330-78-5 31 2

@ TCP

(Listed As: Tricresyl

Phosphate)

1330-78-5 54 *

@ TCP

(Listed As: Tricresyl

Phosphate)

1330-78-5 47 16

@ TCPP

(Listed As:

Tris(Chloropropyl)phosphate)

13674-84-5 33 8

Tebufenpyrad 119168-77-3 53 *

Toxic equivalency factor

evaluation (Binary mixture; PCB

126/PCB 153)

TEFBINARYMIX 46 16

Toxic equivalency

factor evaluation (PECDF

(Pentachlorodibenzofuran))

57117-31-4 46 16

Toxic equivalency factor

evaluation (PCB 118)

31508-00-6 46 16

Toxic equivalency factor

evaluation (PCB Mixture; PCB

126/PCB 118)

TEFPCBMIX 46 16

Toxic equivalency factor

evaluation (TCDD)

1746-01-6 46 16

TEF transgenics (PCB 126) 57465-28-8 53 *

TEF transgenics (PCB 126 / PECDF

mixture)

TEFTGMIXTURE 53 *

TEF transgenics (PECDF) 57117-31-4 53 *

TEF transgenics (TCDD) 1746-01-6 53 *

@ TELONE II

(Listed As: 1,3-

Dichloropropene (Telone II))

542-75-6 41 16

@ TEMIK

(Listed As: Aldicarb)

116-06-3 38 16

Tetrabromobisphenol A 79-94-7 53 *

Tetrabromobisphenol A 79-94-7 46 16

Tetrabromobisphenol

A-bis(2,3-dibromopropyl ether)

21850-44-2 34 12
Last Update: 09/18/2015 10:46 Management Status Report Page 27

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

2,2',4,4'-Tetrabromodiphenyl

Ether (BDE-47)

5436-43-1 53 *

2,2',4,4'-Tetrabromodiphenyl

Ether (BDE-47)

5436-43-1 31 2

2,2',4,4'-Tetrabromodiphenyl

Ether (BDE-47)

5436-43-1 32 4

@ 1,1,1,2-Tetrabromoethane

(Halogenated ethanes CS)

(Listed As: Halogenated

ethanes CS (1,1,1,2-

Tetrabromoethane))

630-16-0 36 16

@ 1,1,1,2-Tetrachloroethane

(Halogenated ethanes CS)

(Listed As: Halogenated

ethanes CS (1,1,1,2-

Tetrachloroethane))

630-20-6 37 16

3,3',4,4'-Tetrachloroazobenzene 14047-09-7 53 *

3,3',4,4'-Tetrachloroazobenzene 14047-09-7 37 16

3,3',4,4'-Tetrachloroazobenzene 14047-09-7 37 16

3,3',4,4'-Tetrachloroazobenzene 14047-09-7 46 16

3,3',4,4'-Tetrachloroazoxybenzene 21232-47-3 37 16

1,2,4,5-Tetrachlorobenzene 95-94-3 37 16

2,3,7,8-Tetrachlorodibenzo-pdioxin1746-01-6 46 16

2,3,7,8-Tetrachlorodibenzo-pdioxin1746-01-6 46 16

Tetrachlorodiphenylethane 72-54-8 46 16

1,1,1,2-Tetrachloroethane 630-20-6 46 16

1,1,2,2-Tetrachloroethane 79-34-5 46 16

1,1,2,2-Tetrachloroethane 79-34-5 37 16

1,1,2,2-Tetrachloroethane 79-34-5 53 *

1,1,2,2-Tetrachloroethane 79-34-5 37 16

@ 1,1,2,2-Tetrachloroethane

(Halogenated ethanes CS)

(Listed As: Halogenated

ethanes CS (1,1,2,2-

Tetrachloroethane))

79-34-5 37 16

Tetrachloroethylene 127-18-4 46 16

Tetrachloroethylene 127-18-4 46 16

2,3,5,6-Tetrachloro-4-

nitroanisole

2438-88-2 46 16

Tetrachlorophthalic anhydride 117-08-8 37 16

Tetrachlorvinphos 961-11-5 46 16

Tetracycline hydrochloride 64-75-5 46 16

Tetradecanoyl phorbol acetate

(TPA)

16561-29-8 53 *

@ Tetradecanoylphorbol acetate

(TPA)

(Listed As: Init/prom

comparative mouse study (DMBA/

TPA/BPO/MNNG))

INIT/PROM 43 16

@ Tetradecanoylphorbol acetate

(TPA)

(Listed As: Init/prom

comparative mouse study (DMBA/

TPA/BPO/MNNG))

INIT/PROM 43 16

@ Tetradecanoylphorbol acetate

(TPA)

(Listed As: Init/prom

comparative mouse study (DMBA/

TPA/BPO/MNNG))

INIT/PROM 43 16

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ Tetradecanoyl phorbol acetate

(TPA) (Transgenic LECM)

(Listed As: Transgenic LECM

(Tetradecanoyl phorbol acetate

(TPA)))

16561-29-8 53 *

Tetraethylthiuram disulfide 97-77-8 46 16

Tetrafluoroethylene 116-14-3 38 16

Tetrafluoroethylene 116-14-3 46 16

1-trans-delta-9-

Tetrahydrocannabinol

1972-08-3 38 16

1-trans-delta-9-

Tetrahydrocannabinol

1972-08-3 46 16

Tetrahydrofuran 109-99-9 53 *

Tetrahydrofuran 109-99-9 38 16

Tetrahydrofuran 109-99-9 46 16

Tetrakis(hydroxymethyl)phosphonium

chloride

124-64-1 46 16

Tetrakis(hydroxymethyl)phosphonium

sulfate

55566-30-8 46 16

Tetralin 119-64-2 46 16

Tetranitromethane 509-14-8 46 16

@ TGMX rat liver evaluation)

(Methyleugenol)

(Listed As: Methyleugenol

(TGMX rat liver evaluation))

93-15-2 52 *

@ TGMX rat liver evaluation (NNitrosodimethylamine)

(Listed As: NNitrosodimethylamine (TGMX rat

liver evaluation))

62-75-9 52 *

Theophylline 58-55-9 38 16

Theophylline 58-55-9 38 16

Theophylline 58-55-9 46 16

4,4-Thiobis(6-tert-butyl-mcresol)96-69-5 53 *

4,4-Thiobis(6-tert-butyl-mcresol)96-69-5 47 16

4,4'-Thiodianiline 139-65-1 47 16

beta-Thioguanidine deoxyriboside 789-61-7 47 16

Thiophene 110-02-1 53 *

@ thio-TEPA

(Listed As: tris(Aziridinyl)-

phosphine sulfide (Thio-TEPA))

52-24-4 47 16

@ THPC

(Listed As: Tetrakis(hydroxymethyl)phosphonium

chloride)

124-64-1 46 16

@ THPS

(Listed As: Tetrakis(hydroxymethyl)phosphonium

sulfate)

55566-30-8 46 16

alpha-Thujone 546-80-5 37 16

alpha/beta Thujone mixture 76231-76-0 37 16

alpha/beta Thujone mixture 76231-76-0 47 16

Titanium dioxide 13463-67-7 47 16

Titanocene dichloride 1271-19-8 47 16

@ TMPTA

(Listed As: Trimethylolpropane

triacrylate)

15625-89-5 35 16

@ TMPTA

(Listed As: Trimethylolpropane

triacrylate)

15625-89-5 35 16

@ TMPTA

(Listed As: Trimethylolpropane

triacrylate)

15625-89-5 47 16
Last Update: 09/18/2015 10:46 Management Status Report Page 28

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

D-alpha-Tocopheryl acetate 58-95-7 53 *

Tolazamide 1156-19-0 47 16

Tolbutamide 64-77-7 47 16

Toluene 108-88-3 47 16

Toluene 108-88-3 38 16

2,6-Toluenediamine

dihydrochloride

(2,6-diaminotoluene

dihydrochloride)

15481-70-6 47 16

2,5-Toluenediamine sulfate 6369-59-1 47 16

2,4- & 2,6-Toluene diisocyanate 26471-62-5 47 16

p-Toluenesulfonamide 70-55-3 34 14

o-Toluidine hydrochloride 636-21-5 47 16

o-Toluidine hydrochloride 636-21-5 37 16

p-Toluidine 106-49-0 33 10

p-Tolylurea 622-51-5 49 17

Toxaphene 8001-35-2 47 16

Toxic equivalency factor

evaluation (Dioxin mixture)

TEFDIOXINMIX 47 16

Toxic equivalency factor

evaluation (PCB 153- 2,2'-

4,4',5,5'-hexachlorobiphenyl)

35065-27-1 47 16

Toxic equivalency factor

evaluation ((PCB 126)

3,3',4,4',5-pentachlorobiphenyl)

57465-28-8 47 16

Toxicogenomics study of

allylbenzene & propenylbenzene

class flavor constituents (TGMX)

TGMXFLAVCLAS 53 *

Transgenic LECM

(1-Chloro-2-propanol, technical)

127-00-4 53 *

Transgenic LECM

(1-Chloro-2-propanol, technical)

127-00-4 53 *

Transgenic LECM (Coconut oil acid

diethanolamine condensate)

68603-42-9 53 *

Transgenic LECM (Coconut oil acid

diethanolamine condensate)

68603-42-9 53 *

Transgenic LECM (Furfuryl

alcohol)

98-00-0 53 *

Transgenic LECM (Lauric acid

diethanolamine condensate)

120-40-1 53 *

Transgenic LECM (Lauric acid

diethanolamine condensate)

120-40-1 53 *

Transgenic LECM (Oleic acid

diethanolamine condensate)

93-83-4 53 *

Transgenic LECM (Oleic acid

diethanolamine condensate)

93-83-4 53 *

Transgenic LECM

(Pentachlorophenol)

87-86-5 53 *

Transgenic LECM

(Pentachlorophenol)

87-86-5 53 *

Transgenic LECM (Pyridine) 110-86-1 53 *

Transgenic LECM (Pyridine) 110-86-1 53 *

Transgenic LECM (Tetradecanoyl

phorbol acetate (TPA))

16561-29-8 53 *

Transgenic LEP (p-Anisidine

hydrochloride)

20265-97-8 53 *

Transgenic LEP (Cyclosporin A) 59865-13-3 53 *

Transgenic LEP (Melphalan) 148-82-3 53 *

Transgenic LEP (p-Cresidine) 120-71-8 53 *

Transgenic LEP (Resorcinol) 108-46-3 53 *

Transgenic LEP (Vinyl carbamate) 15805-73-9 53 *

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Transgenic model evaluation

(p-Anisidine HCl)

20265-97-8 53 *

Transgenic model evaluation

(Bromodichloromethane)

75-27-4 54 *

Transgenic model evaluation

(Bromodichloromethane)

75-27-4 54 *

Transgenic model evaluation

(Cyclophosphamide monohydrate)

6055-19-2 54 *

Transgenic model evaluation

(Cyclophosphamide monohydrate)

6055-19-2 54 *

Transgenic model evaluation

(Cyclosporin A)

59865-13-3 54 *

Transgenic model evaluation

(Cyclosporin A)

59865-13-3 54 *

Transgenic model evaluation (DES) 56-53-1 54 *

Transgenic model evaluation (DES) 56-53-1 54 *

Transgenic model evaluation (DES) 56-53-1 54 *

Transgenic model evaluation (DES) 56-53-1 54 *

Transgenic model evaluation

(2,4-Diaminotoluene)

95-80-7 54 *

Transgenic model evaluation

(2,4-Diaminotoluene)

95-80-7 54 *

Transgenic model evaluation

(2,6-Diaminotoluene 2HCl)

15481-70-6 54 *

Transgenic model evaluation

(2,6-Diaminotoluene 2HCl)

15481-70-6 54 *

Transgenic model evaluation

(Di(2-ethylhexyl) phthalate)

117-81-7 54 *

Transgenic model evaluation

(Di(2-ethylhexyl) phthalate)

117-81-7 54 *

Transgenic model evaluation

(Ethinyl estradiol)

57-63-6 54 *

Transgenic model evaluation

(Ethinyl estradiol)

57-63-6 54 *

Transgenic model evaluation

(8-Hydroxyquinoline)

148-24-3 54 *

Transgenic model evaluation

(8-Hydroxyquinoline)

148-24-3 54 *

Transgenic Model Evaluation II

(Acesulfame Potassium)

55589-62-3 35 16

Transgenic model evaluation II

(Aspartame)

22839-47-0 35 16

Transgenic model evaluation II

(Aspartame)

22839-47-0 35 16

Transgenic model evaluation II

(Benzene)

71-43-2 35 16

Transgenic model evaluation II

(Glycidol)

556-52-5 35 16

Transgenic model evaluation II

(Phenolphthalein)

77-09-8 35 16

Transgenic model evaluation

(Melphalan)

148-82-3 54 *

Transgenic model evaluation

(Melphalan)

148-82-3 54 *

Transgenic model evaluation

(Melphalan)

148-82-3 54 *

Transgenic model evaluation

(Melphalan)

148-82-3 54 *

Transgenic model evaluation

(Melphalan)

148-82-3 54 *

Transgenic model evaluation

(N-Methylolacrylamide)

924-42-5 54 *
Last Update: 09/18/2015 10:46 Management Status Report Page 29

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Transgenic model evaluation

(N-Methylolacrylamide)

924-42-5 54 *

Transgenic model evaluation

(Methylphenidate hydrochloride)

298-59-9 54 *

Transgenic model evaluation

(Phenolphthalein)

77-09-8 54 *

Transgenic model evaluation

(Resorcinol)

108-46-3 54 *

Transgenic model evaluation

(Resorcinol)

108-46-3 54 *

Transgenic model evaluation

(Rotenone)

83-79-4 54 *

Transgenic model evaluation

(Rotenone)

83-79-4 54 *

Transgenic Model Evaluation

(2,3,7,8-

Tetrachlorodibenzodioxin)

1746-01-6 54 *

Transgenic Model Evaluation

(2,3,7,8-

Tetrachlorodibenzodioxin)

1746-01-6 54 *

Transgenic Model Evaluation

(2,3,7,8-

Tetrachlorodibenzodioxin)

1746-01-6 54 *

Transgenic Model Evaluation

(2,3,7,8-

Tetrachlorodibenzodioxin)

1746-01-6 54 *

Transgenic model evaluation

(WY-14643)

50892-23-4 54 *

Transgenic model evaluation

(WY-14643)

50892-23-4 54 *

Transgenic LECM (diethanolamine) 111-42-2 54 *

Tremolite 14567-73-8 47 16

Triamterene 396-01-0 54 *

Triamterene 396-01-0 47 16

Tribromomethane 75-25-2 47 16

Tricaprylin 538-23-8 47 16

Trichlorfon 52-68-6 54 *

1,1,1-Trichloroethane 71-55-6 47 16

1,1,1-Trichloroethane 71-55-6 37 16

1,1,2-Trichloroethane 79-00-5 47 16

@ 1,1,1-Trichloroethane

(Halogenated ethanes CS)

(Listed As: Halogenated

ethanes CS (1,1,1-

Trichloroethane))

71-55-6 37 16

Trichloroethylene 79-01-6 47 16

Trichloroethylene 79-01-6 47 16

Trichloroethylene 79-01-6 47 16

Trichloroethylene 79-01-6 47 16

Trichloroethylene 79-01-6 54 *

Trichloroethylene 79-01-6 54 *

Trichlorofluoromethane 75-69-4 47 16

2,4,6-Trichlorophenol 88-06-2 47 16

1,2,3-Trichloropropane 96-18-4 54 *

1,2,3-Trichloropropane 96-18-4 47 16

@ 1,1,1-Trichloro-2,2,2-

trifluoroethane(Halogenated

ethanes CS)

(Listed As: Halogenated

ethanes CS (1,1,1-Trichloro2,2,2-trifluoroethane))

354-58-5 37 16

Triclocarban 101-20-2 31 3

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Triclosan 3380-34-5 54 *

Triclosan 3380-34-5 33 7

Tricresyl Phosphate 1330-78-5 54 *

Tricresyl Phosphate 1330-78-5 31 2

Tricresyl Phosphate 1330-78-5 54 *

Tricresyl Phosphate 1330-78-5 47 16

Triethanolamine 102-71-6 54 *

Triethanolamine 102-71-6 54 *

Triethanolamine 102-71-6 54 *

Triethanolamine 102-71-6 47 16

Triethanolamine 102-71-6 47 16

Triethylamine 121-44-8 12

Trifluralin 1582-09-8 47 16

Trimellitic anhydride 552-30-7 54 *

Trimellitic anhydride 552-30-7 54 *

2,4,5-Trimethylaniline 137-17-7 47 16

1,2,4-trimethylbenzene 95-63-6 32 4

Trimethylolpropane triacrylate 15625-89-5 35 16

Trimethylolpropane triacrylate 15625-89-5 35 16

Trimethylolpropane triacrylate 15625-89-5 47 16

Trimethylphosphate 512-56-1 47 16

Trimethylsilyldiazomethane (TMSD) 18107-18-1 32 4

Trimethylthiourea 2489-77-2 47 16

2,4,7-Trinitro-fluoren-9-one 129-79-3 37 16

2,4,7-Trinitro-fluoren-9-one 129-79-3 37 16

Tripelennamine hydrochloride 154-69-8 54 *

Triphenyl Phosphate 115-86-6 31 2

Triphenyl Phosphate 115-86-6 32 5

Triphenyltin hydroxide 76-87-9 47 16

Triprolidine 486-12-4 47 16

tris(Aziridinyl)-phosphine

sulfide (Thio-TEPA)

52-24-4 47 16

Tris(2-Chloroethyl) Phosphate 115-96-8 47 16

Tris(Chloropropyl)phosphate 13674-84-5 33 8

tris(2,3-Dibromopropyl) phosphate 126-72-7 47 16

tris(2-Ethylhexyl)phosphate 78-42-2 47 16

Trisodium

ethylenediaminetetraacetate

trihydrate (EDTA)

150-38-9 47 16

L-Tryptophan 73-22-3 47 16

Tungsten 7440-33-7 32 5

Tungsten Suboxide Fibers TUNGSTENFIB 32 5

Tungsten trioxide 1314-35-8 32 4

Turmeric, oleoresin (curcumin) 8024-37-1 47 16

Uracil mustard 66-75-1 49 17

Urethane 51-79-6 37 16

Urethane 51-79-6 47 16

Urethane + ethanol (combination) URETHCOMB 37 16

Urethane + ethanol (combination) URETHCOMB 47 16

Usnea Lichen USNEALICHEN 33 6

(+)-Usnic Acid 7562-61-0 33 6

Valerian (Valeriana officinalis

L.) root extract

8057-49-6 31 3

Vanadium pentoxide 1314-62-1 38 16

Vanadium pentoxide 1314-62-1 47 16

Vanadyl sulfate 27774-13-6 32 5
Last Update: 09/18/2015 10:46 Management Status Report Page 30

@ Denotes common names--see following line for correct name.

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

Vanadyl sulfate 27774-13-6 31 3

Vinblastine 865-21-4 49 17

Vincamine 1617-90-9 55 *

Vinclozolin 50471-44-8 55 *

Vincristine 57-22-7 49 17

4-Vinylcyclohexene 100-40-3 47 16

4-Vinyl-1-cyclohexene diepoxide 106-87-6 47 16

Vinylidene Chloride 75-35-4 47 16

Vinylidene Chloride 75-35-4 47 16

Vinylidene fluoride 75-38-7 55 *

Vinyl toluene 25013-15-4 47 16

@ Vitamin C

(Listed As: L-Ascorbic acid)

50-81-7 39 16

@ Vitamin E Acetate

(Listed As: D-alpha-Tocopheryl

acetate)

58-95-7 53 *

Water disinfection byproducts

(Bromochloroacetic acid)

5589-96-8 47 16

Water disinfection byproducts

(Bromodichloroacetic Acid)

71133-14-7 55 *

Water disinfection byproducts

(Bromodichloroacetic Acid)

71133-14-7 34 14

Water disinfection byproducts

(Bromodichloromethane)

75-27-4 55 *

Water disinfection byproducts

(Bromodichloromethane)

75-27-4 55 *

Water disinfection byproducts

(Bromodichloromethane)

75-27-4 47 16

Water disinfection byproducts

(Dibromoacetic acid)

631-64-1 55 *

Water disinfection byproducts

(Dibromoacetic acid)

631-64-1 47 16

Water disinfection byproducts

(Dibromoacetonitrile)

3252-43-5 47 16

Water disinfection byproducts

(Dichloroacetic acid)

79-43-6 55 *

Water disinfection byproducts

(Sodium chlorate)

7775-09-9 47 16

Water disinfection model

(Bromodichloromethane)

75-27-4 35 16

Water disinfection model

(Bromodichloromethane)

75-27-4 35 16

Water disinfection model

(Bromodichloromethane)

75-27-4 35 16

Water disinfection model

(Bromodichloromethane)

75-27-4 35 16

Water disinfection model

(Bromodichloromethane)

75-27-4 35 16

Water disinfection model

(Dichloroacetic acid)

79-43-6 35 16

Water disinfection model

(Dichloroacetic acid)

79-43-6 35 16

Water disinfection model

(Dichloroacetic acid)

79-43-6 35 16

Water disinfection model (Sodium

bromate)

7789-38-0 35 16

Water disinfection model (Sodium

bromate)

7789-38-0 35 16

Water disinfection model (Sodium

bromate)

7789-38-0 35 16

Welding fumes STEELWELDFUM 55 *

Alphabetical Index of Chemicals with Reference Location

CHEMICAL NAME CASRN PAGE REF

@ West Fork Mine Ore (Missouri)

(Listed As: Lead ores)

LEADORES 51 *

Wollastonite calcium silicates 13983-17-0 49 17

@ WY-14643 (Peroxisome project)

(Listed As: Peroxisome project

(WY-14643))

50892-23-4 37 16

@ WY-14643 (Transgenic model

evaluation)

(Listed As: Transgenic model

evaluation (WY-14643))

50892-23-4 54 *

@ WY-14643 (Transgenic model

evaluation)

(Listed As: Transgenic model

evaluation (WY-14643))

50892-23-4 54 *

Wyeth 14,643 (WY) 50892-23-4 33 6

Wyeth 14,643 (WY) 50892-23-4 55 *

Xylenes (mixed) 1330-20-7 48 16

2,6-Xylidine 87-62-7 48 16

@ Yellow 12, C.I. Pigment

(Listed As: Diarylanilide

yellow)

6358-85-6 41 16

@ Yellow 3, C.I. Disperse

(Listed As: C.I. Disperse

Yellow 3)

2832-40-8 41 16

@ Yellow 14, C.I. Solvent

(Listed As: C.I. Solvent

Yellow 14)

842-07-9 41 16

@ Yellow 4, C.I. Vat

(Listed As: C.I. Vat Yellow 4)

128-66-5 41 16

@ Yellow 4, HC

(Listed As: HC Yellow 4)

59820-43-8 43 16

@ Yellow No. 11, D & C

(Listed As: D&C Yellow No. 11)

8003-22-3 36 16

@ Yellow No. 11, D & C

(Listed As: D&C Yellow No. 11)

8003-22-3 41 16

@ Yellow No. 6, FD & C

(Listed As: FD & C Yellow No.

6)

2783-94-0 42 16

Zearalenone 17924-92-4 48 16

Zinc Carbonate, Basic 5263-02-5 33 10

Ziram 137-30-4 48 16
Last Update: 09/18/2015 10:46 Management Status Report Page 31

Ref No. 2

Chemicals with Project Leader Assigned/Study in Design

CHEMICAL NAME PRIMARY CAS

NUMBER

USE

Aluminum fluoride 7784-18-1 ENVH/SYN

Annatto 1393-63-1 COSM/NATL

Artificial Butter Flavoring Mixture BUTTERFLAVMX SYN

BDE Toxicogenomics Study (TGMX) TGMXBDECLASS

tert-Butylphenyl Diphenyl Phosphate 56803-37-3

bis(2-Chloroethoxy)methane 111-91-1 SOLV/SYN

Cumene 98-82-8 ENVH/N/S

Deoxynivalenol 51481-10-8 COMT/NATL

2,6-Diaminopyridine 141-86-6 INTR/SYN

3-(Dimethylamino)propylamine 109-55-7 DTRG/SYN

Dong quai Angelica sinensis root extract 299184-76-2 DIET

2-Ethylhexyl Diphenyl Phosphate 1241-94-7

2-ethyltoluene 611-14-3 LABC

3-ethyltoluene 620-14-4 LABC

4-ethyltoluene 622-96-8 FUEL

Ginkgo biloba extract 90045-36-6 DIET/NATL

Goldenseal extract 84603-60-1 NATL/N/S

Green Tea Extract GREENTEAEXTR DIET/NATL

2,2',4,4',5,5'-Hexabromodiphenyl ether

(PBDE 153)

68631-49-2 FLAM/SYN

Isodecyl Diphenyl Phosphate 29761-21-5 PLAS

Microcystin LR 101043-37-2 ENVH/NATL

Naturally occurring asbestos and related

mineral fibers

ASBESTOSFIB ELEC/N/S

2,2',4,4',5-Pentabromodiphenyl Ether 60348-60-9 ENVH/SYN

Pentabromodiphenyl Oxide (Technical) (DE

71)

32534-81-9 FLAM/SYN

Propyl-4-hydroxybenzoate 94-13-3 FOOD/SYN

Sodium Metavanadate 13718-26-8 COMT/SYN

2,2',4,4'-Tetrabromodiphenyl Ether (BDE-47) 5436-43-1 ENVH/SYN

Tricresyl Phosphate 1330-78-5 FLAM/SYN

Triphenyl Phosphate 115-86-6 FLAM/SYN

Ref No. 3

Chemicals Approved for Toxicology/Carcinogenesis Study

CHEMICAL NAME PRIMARY CAS

NUMBER

USE

Alternaria alternata mold ALTERNARIA NATL/NATL

Aspergillus fumigatus mold ASPERGILLUS NATL/NATL

N-Butylbenzenesulfonamide 3622-84-2 PLAS/SYN

Cylindrospermopsin 143545-90-8 ENVH/NATL

Damp Building Mold Mixture DAMPBLDGMOLD NATL/NATL

2,2'-Dimorpholinodiethyl Ether 6425-39-4 IND/SYN

Fluorotelomer Alcohol 8+2 678-39-7 SYN

Nanoscale Material (Fullerene C60 18

microns)

99685-96-8 NANO/N/S

Nanoscale Material (Fullerene C60 200

nanometers)

99685-96-8 NANO

Pentabromodiphenyl Oxide (Technical) (DE

71)

32534-81-9 FLAM/SYN

Stachybotrys chartarum 67892-26-6 NATL

Stachybotrys chartarum strain 1 mold

(macrocyclic trichothecene chemotype)

STACHYSTRN1 NATL/NATL

Stachybotrys chartarum strain 2 mold

(atranone chemotype)

STACHYSTRN2 NATL/NATL

Tetrabromobisphenol A-bis(2,3-dibromopropyl

ether)

21850-44-2 FLAM/SYN

Triclocarban 101-20-2 PEST/SYN

Valerian (Valeriana officinalis L.) root

extract

8057-49-6 DIET/NATL

Vanadyl sulfate 27774-13-6 DYE

Water Damaged Building Mold Mixture H2ODAMAGEMLD NATL/NATL

Ref No. 4

Chemicals Assigned to Laboratory for Toxicology/Carcinogenesis Study

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES

Asbestos, amosite 12172-73-5 NSUL/NATL INHAL

Aspergillus versicolor mold ASPERGILLUSV NATL/NATL INHAL M3

Phenolic Benzotriazoles (2-(2HBenzotriazol-2-yl)-4-tert-butylphenol)3147-76-0 ADHS GAV HSD

Bisphenol S 80-09-1 ADHS FEED M3

Decabromodiphenyl ether 1163-19-5 FLAM
Last Update: 09/18/2015 10:46 Management Status Report Page 32

Ref No. 4

Chemicals Assigned to Laboratory for Toxicology/Carcinogenesis Study

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES

Dipropylene glycol phenyl ether 51730-94-0 IND/SYN GAV HSD

Phenolic Benzotriazoles (Drometrizole) 2440-22-4 IND GAV HSD

1,2-bis(pentabromophenyl)ethane 84852-53-9 FLAM/SYN

Firemaster 680 37853-59-1 FLAM

1,3,5,7,9,11-Hexabromocyclododecane 25637-99-4 FLAM

Hexachlorocyclopentadienyldibromocyclooctane51936-55-1 FLAM/SYN

Phenolic Benzotriazoles (3-(2HBenzotriazol-2-yl)-5-(1,1-dimethylethyl)-4-

hydroxybenzenepropanoic acid, octyl ester)

84268-23-5 ADHS GAV HSD

Insertional Mutagenesis - Definitive Vector

Study

INSERTMUT3 N/A IV M1

Libby Amphibole 1318-09-8 MINL/NATL INHAL

1020 Long Multiwalled Carbon Nanotube L-MWNT-1020 INHAL M3 HSD

Phenolic Benzotriazoles (Octrizole) 3147-75-9 IND GAV HSD

Pentabromodiphenyl Oxide (Technical) (DE

71)

32534-81-9 FLAM/SYN GAV RE

3,3,4,4,5-Pentachlorobiphenyl (PCB 126) 57465-28-8 ELEC/SYN GAV RE

Phenolic Benzotriazoles

(2-(2H-Benzotriazol-2-yl)phenol)

10096-91-0 ADHS GAV HSD

Phenolic Benzotriazoles (Phenol, 2-(2Hbenzotriazol-2-yl)-4,6-bis(1,1-

dimethylpropyl)-)

25973-55-1 PEST GAV HSD

Phenolic Benzotriazoles (Phenol, 2-(2Hbenzotriazol-2-yl)-4,6-bis(1-methyl-1-

phenylethyl)-)

70321-86-7 IND GAV HSD

Phenolic Benzotriazoles (2-(5-Chloro2Hbenzotriazol-2-yl)-4,6bis(1,1

dimethylethyl)phenol)

3864-99-1 IND GAV HSD

Phenolic Benzotriazoles (Bumetrizole) 3896-11-5 IND GAV HSD

2-ethylhexyl-2,3,4,5-tetrabromobenzoate 183658-27-7 ENVH/SYN

2,2',4,4'-Tetrabromodiphenyl Ether (BDE-47) 5436-43-1 ENVH/SYN GAV RE

2,2',4,4'-Tetrabromodiphenyl Ether (BDE-47) 5436-43-1 ENVH/SYN

Bis(2-ethylhexyl) tetrabromophthalate 26040-51-7 PLAS/SYN

1,2,4-trimethylbenzene 95-63-6 DYE INHAL M3 HSD

Trimethylsilyldiazomethane (TMSD) 18107-18-1 REAG/SYN INHAL M3 HSD

Tungsten trioxide 1314-35-8 SYN IT HSD

Ref No. 5

Short-Term Exposure Studies in Progress

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPD D*

START

DATE

SUBCHR

START

DATE

Aflatoxin B1 (TGMX) 1162-65-8 LABC/NATL R2

N-Butylbenzenesulfonamide 3622-84-2 PLAS/SYN FEED M3 02/14A

Crude MCHM CRUDEMCHM IND/SYN GAV HSD 09/14A

Dimethylamine Borane 74-94-2 DERMAL M3 HSD 01/14A

Garcinia Cambogia Extract 90045-23-1 DIET/NATL FEED M3 HSD 04/14A

Ionic Liquid: 1-Butyl-3-methylimidazolium

Chloride

79917-90-1 COSM/SYN WATER M3 HSD 04/13A

Ionic Liquid: 1-Butyl-1-methylpyrrolidinium

Chloride

479500-35-1 LABC/SYN WATER M3 HSD 08/13A

Ionic Liquid: N-Butylpyridinium Chloride 1124-64-7 ELEC/SYN WATER M3 HSD 09/13A

Ionic Liquid: 1-Ethyl-3-methylimidazolium

Chloride

65039-09-0 IND/SYN WATER M3 HSD 05/13A

Isopropylated Phenol Phosphate 68937-41-7 FLAM/SYN FEED M3 12/14A

Melamine + Cyanuric Acid combination MELCYANCOMB ADHS/SYN GAV RC 07/11A

4-Methylcyclohexanemethanol 34885-03-5 IND/SYN GAV HSD 09/14A

Nanoscale Silver 7440-22-4 TBCO/NATL GAV 44 09/11A

Pentabromodiphenyl Oxide (Technical) (DE

71)

32534-81-9 FLAM/SYN GAV RE

Perfluorohexane sulfonate potassium salt

(PFHSKslt)

3871-99-6 PLAS/SYN GAV HSD 02/12A

Phenobarbital 50-06-6 PHAR/SYN GAV RE

Propylene glycol phenyl ether 770-35-4 SOLV/SYN GAV HSD 09/14A

Pyridine 110-86-1 SOLV/SYN GAV M3 10/10A

Sodium Metavanadate 13718-26-8 COMT/SYN WATER M3 HSD 10/14A

Triphenyl Phosphate 115-86-6 FLAM/SYN FEED M3 02/15A

Tungsten 7440-33-7 NATL IT HSD 07/14A

Tungsten Suboxide Fibers TUNGSTENFIB ELEC/NATL IT HSD 07/14A

Vanadyl sulfate 27774-13-6 DYE WATER M3 HSD 09/14A

* RPD D = REPEATED DOSE; SUBCHR = SUBCHRONIC; (A)CTUAL OR (E)STIMATED DATES
Last Update: 09/18/2015 10:46 Management Status Report Page 33

Ref No. 6

Short-Term Studies Completed: In Review for Further Evaluation

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPD D*

START

DATE

SUBCHR

START

DATE

Perfluorobutane sulfonate (PFBS) 375-73-5 IND/SYN GAV HSD 01/12A

Perfluorodecanoic Acid 335-76-2 IND/SYN GAV HSD 02/12A

Perfluorohexanoic acid (PFHXA) 307-24-4 FDPK/SYN GAV HSD 01/12A

Perfluorononanoic Acid 375-95-1 FDPK/SYN GAV HSD 02/12A

Perfluorooctane Sulfonate 1763-23-1 SYN GAV HSD 01/12A

Perfluorooctanoic Acid 335-67-1 ELEC/SYN GAV HSD 01/12A

Sulfolane 126-33-0 ADHS GAV M3 HSD

O6

01/14A

Usnea Lichen USNEALICHEN DIET/NATL FEED RC MV 01/07A 02/09A

(+)-Usnic Acid 7562-61-0 NATL/NATL FEED RC MV 12/06A 08/08A

Wyeth 14,643 (WY) 50892-23-4 PHAR/SYN GAV HSD 01/12A

* RPD D = REPEATED DOSE; SUBCHR = SUBCHRONIC; (A)CTUAL OR (E)STIMATED DATES

Ref No. 7

Long-Term Exposure Studies in Progress

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES CHRONIC

START

DATE

alpha-Pinene 80-56-8 SOLV/SYN INHAL M3 HSD 02/15A

Sulfolane 126-33-0 ADHS WATER M3 HSD 05/15A

Triclosan 3380-34-5 COSM/SYN DERMAL M3 09/13A

Ref No. 8

Long-Term Exposure Studies: Laboratory Study Report in Preparation

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES

Aging Cohort Study: 129/SvlmJ mouse MOUSEPHENO1 N/A N/A MR

Aging Cohort Study: B6C3F1J mouse MOUSEPHENO6 N/A N/A 63

Aging Cohort Study: C3H/HeJ mouse MOUSEPHENO3 N/A N/A M15

Aging Cohort Study: C57/BL/6J mouse MOUSEPHENO4 N/A N/A MZ

Aging Cohort Study: CAST/EiJ mouse MOUSEPHENO5 N/A N/A M11

Aging Cohort Study: NZO/HiLtJ mouse MOUSEPHENO10 N/A N/A 61

Aging Cohort Study: PWK/PhJ mouse MOUSEPHENO8 N/A N/A 62

Aging Cohort Study: WSB/EIJ mouse MOUSEPHENO9 N/A N/A M14

Aging Cohort Study: A/J mouse MOUSEPHENO2 N/A N/A MF

Aging Cohort Study: NOD. B10Sn-H2(b)/J MOUSEPHENO7 N/A N/A 60

AZT/Drug Combinations

Transplacental/Neonatal Study

AIDSDRUGSNEO PHAR/SYN GAV M3 MV

Bisphenol A 80-05-7 INTR/SYN GAV 44

Black Cohosh 84776-26-1 DIET/NATL GAV M3 HSD

Cell Phone Radiation: CDMA CELLPRADCDMA N/A WB M3 HSD

Cell Phone Radiation: GSM CELLPRADGSM N/A WB M3 HSD

Furan 110-00-9 DTRG/N/S GAV RC

Insertional Mutagenesis - Definitive Vector

Study

INSERTMUT3 N/A IV M1

Resveratrol 501-36-0 CMOT/NATL GAV RE RD M3

HSD

Sodium Tungstate Dihydrate 10213-10-2 FLAM/NATL WATER M3 HSD

Tris(Chloropropyl)phosphate 13674-84-5 PEST FEED M3 HSD

Ref No. 10

Long-Term Exposure Studies: Pathology Quality Assessment in Progress

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES

2,3-Butanedione 431-03-8 FOOD/N/S INHAL RE M3

p-Chloro-a,a,a-trifluorotoluene 98-56-6 SYN INHAL M3 HSD

Dibutyl Phthalate 84-74-2 FUNG/SYN FEED M3 HSD

Di(2-ethylhexyl) Phthalate 117-81-7 PLAS/SYN FEED HSD

Di(2-ethylhexyl) Phthalate 117-81-7 PLAS/SYN FEED HSD

N,N-Dimethyl-p-toluidine 99-97-8 INTR/SYN GAV RD M3

2-Hydroxy-4-methoxybenzophenone 131-57-7 COSM/SYN FEED M3 HSD

Perfluorooctanoic Acid 335-67-1 ELEC/SYN FEED HSD

Perfluorooctanoic Acid 335-67-1 ELEC/SYN FEED HSD

p-Toluidine 106-49-0 INTR/SYN GAV RD

Zinc Carbonate, Basic 5263-02-5 NATL/NATL FEED HSD
Last Update: 09/18/2015 10:46 Management Status Report Page 34

Ref No. 12

Short-Term Exposure Studies Scheduled for Peer Review

Short-Term Studies

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No.

alpha-Pinene 80-56-8 SOLV/SYN INHAL R2 M3

Indole-3-carbinol 700-06-1 DIET/N/S GAV R2 M3

Nanoscale material (Fullerene-C60 1 micron) 99685-96-8 SYN INHAL RE M3

Nanoscale material (Fullerene-C60 50

nanometers)

99685-96-8 SYN INHAL RE M3

2,3-Pentanedione 600-14-6 FOOD/SYN INHAL RE M3

ortho-Phthalaldehyde 643-79-8 GERM INHAL M3 HSD

Serotype 2 Adeno-associated Viral Vector

hAQP1 (rAAV2hAQP1)

AAV2HAQP1 ID/CN MW

Tetrabromobisphenol A-bis(2,3-dibromopropyl

ether)

21850-44-2 FLAM/SYN GAV RD M3

Triethylamine 121-44-8 INTR/SYN INHAL R2 M3

Ref No. 13

Long-Term Exposure Studies Scheduled for Peer Review

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No.

Antimony Trioxide 1309-64-4 DYE/N/S INHAL RE M3

1020 Long Multiwalled Carbon Nanotube L-MWNT-1020 INHAL M3 HSD

Metal Working Fluids: Trim VX TRIMVX METL/SYN INHAL RE M3

Pentabromodiphenyl Oxide (Technical) (DE

71)

32534-81-9 FLAM/SYN GAV R2 RE M3

Ref No. 14

Post Peer Review Technical Reports in Progress

Short-Term Studies

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No.

Abrasive Blasting Agents: Blasting Sand BLASTINGSAND IND/NATL INHAL RD HSD

Abrasive Blasting Agents: Specular Hematite HEMATITESPEC IND/NATL INHAL RD HSD

Acetoin 513-86-0 FOOD/N/S INHAL RE M3

5-Amino-o-cresol 2835-95-2 COSM/SYN SP RD M3

Cedarwood oil 8000-27-9 COSM/NATL SP R2 M3

o-Chloropyridine 109-09-1 COSM/SYN WATER R2 M3

Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E

Super®; OTNE)

54464-57-2 COSM/SYN SP RD M3

Hexachlorobenzene 118-74-1 FUNG/SYN GAV HSD

PCN 66/67 comparison study PCNCOMPARISN SYN GAV R8 R2

HSD

Serotype 5 Adeno-associated Viral Vector

(rAAV5SCTLA4:Ig)

RAV5SCTLA4IG N/A ID/CN MW

Serotype 2 Adeno-associated Viral Vector

rAAV2rapahEpo

AAVIRAAVHEPO NATL ID/CN MW

Sodium thioglycolate 367-51-1 COSM/SYN SP R2 M3

p-Toluenesulfonamide 70-55-3 PEST/SYN FEED RD M3

Ref No. 14

Post Peer Review Technical Reports in Progress

Long-Term Studies

CARCINOGEN

CODES

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No. MR FR MM FM*+

Green Tea Extract GREENTEAEXTR DIET/NATL GAV RD RE M3 NE NE NE NE

Indole-3-carbinol 700-06-1 DIET/N/S GAV M3 HSD NE SE CE CE

Metal Working Fluids: CIMSTAR 3800 CIMSTAR3800 METL/SYN INHAL RE RD M3 TR-586 EE EE NE NE

Water disinfection byproducts

(Bromodichloroacetic Acid)

71133-14-7 ENVH/NATL WATER RD M3 CE CE CE CE

*+ MR = Male Rat, FR = Female Rat, MM = Male Mice, FM = Female Mice.

See Page 4 for explanation of Carcnogen Codes

** The NCI and the NTP Technical Reports for the following chemicals are available from the National Technical

Information Service (NTIS), Department of Commerce, 5285 Port Royal Road, Springfield, Virginia 22161, Phone: (703)

605-6000 or 1-800-553-6847 (rush orders only). Technical reports numbered 220 or higher may also be available from

Central Data Management (CDM) (TELEPHONE: 919-541-3419; FAX: (301) 480-3210; Mail Drop K2-05, NIEHS, P. O. BOX 12233,

Research Triangle Park, NC USA 27709; EMAIL: CDM@NIEHS.NIH.GOV) . All requests containing checks, money orders, or

purchase orders should be sent to NTIS.
Last Update: 09/18/2015 10:46 Management Status Report Page 35

Ref No. 16

Printed Long-Term and Short-Term Study Reports

Genetically Modified Model Studies

CARCINOGEN

CODES

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No. NTIS **

NUMBER

MR FR MM FM*+

Allyl bromide 106-95-6 COSM/SYN GAV M1 MD GMM-07 PB2008-109736

Allyl bromide 106-95-6 COSM/SYN GAV ME MI GMM-07 PB2008-109736

Dicyclohexylcarbodiimide 538-75-0 IND/SYN SP R2 M3 GMM-09 PB2008-109738

Dicyclohexylcarbodiimide 538-75-0 IND/SYN SP ME GMM-09 PB2008-109738

Dicyclohexylcarbodiimide 538-75-0 IND/SYN SP MD GMM-09 PB2008-109738

Diisopropylcarbodiimide 693-13-0 INTR/SYN SP ME GMM-10 PB2008-109739

Diisopropylcarbodiimide 693-13-0 INTR/SYN SP MD GMM-10 PB2008-109739

Pentaerythritol triacrylate 3524-68-3 PLAS SP R2 M3 GMM-04 PB2006-105551

Pentaerythritol triacrylate 3524-68-3 PLAS SP ME GMM-04 PB2006-105551

Transgenic Model Evaluation II (Acesulfame

Potassium)

55589-62-3 FOOD FEED MD ME GMM-02 PB2006-103440

Transgenic model evaluation II (Aspartame) 22839-47-0 FOOD/SYN FEED ME MD GMM-01 PB2006-103430

Transgenic model evaluation II (Aspartame) 22839-47-0 FOOD/SYN FEED MQ GMM-01 PB2006-103430

Transgenic model evaluation II (Benzene) 71-43-2 DYE/N/S GAV MQ GMM-08 PB2008-109737

Transgenic model evaluation II (Glycidol) 556-52-5 COSM/SYN GAV MQ GMM-13 PB2008-109742

Transgenic model evaluation II

(Phenolphthalein)

77-09-8 DYE/SYN FEED MQ GMM-12 PB2008-109741

Trimethylolpropane triacrylate 15625-89-5 ADHS SP R2 M3 GMM-03 PB2006-105550

Trimethylolpropane triacrylate 15625-89-5 ADHS SP ME GMM-03 PB2006-105550

Water disinfection model

(Bromodichloromethane)

75-27-4 FLAM/SYN WATER MD GMM-05 PB2008-109734

Water disinfection model

(Bromodichloromethane)

75-27-4 FLAM/SYN SP ME MI GMM-05 PB2008-109734

Water disinfection model

(Bromodichloromethane)

75-27-4 FLAM/SYN GAV MD GMM-05 PB2008-109734

Water disinfection model

(Bromodichloromethane)

75-27-4 FLAM/SYN WATER ME GMM-05 PB2008-109734

Water disinfection model

(Bromodichloromethane)

75-27-4 FLAM/SYN GAV ME GMM-05 PB2008-109734

Water disinfection model (Dichloroacetic

acid)

79-43-6 GERM/SYN WATER MD GMM-11 PB2008-109740

Water disinfection model (Dichloroacetic

acid)

79-43-6 GERM/SYN SP ME MI GMM-11 PB2008-109740

Water disinfection model (Dichloroacetic

acid)

79-43-6 GERM/SYN WATER ME GMM-11 PB2008-109740

Water disinfection model (Sodium bromate) 7789-38-0 COSM/SYN WATER MD GMM-06 PB2008-109735

Water disinfection model (Sodium bromate) 7789-38-0 COSM/SYN SP ME MI GMM-06 PB2008-109735

Water disinfection model (Sodium bromate) 7789-38-0 COSM/SYN WATER ME GMM-06 PB2008-109735

*+ MR = Male Rat, FR = Female Rat, MM = Male Mice, FM = Female Mice.

See Page 4 for explanation of Carcnogen Codes

** The NCI and the NTP Technical Reports for the following chemicals are available from the National Technical

Information Service (NTIS), Department of Commerce, 5285 Port Royal Road, Springfield, Virginia 22161, Phone: (703)

605-6000 or 1-800-553-6847 (rush orders only). Technical reports numbered 220 or higher may also be available from

Central Data Management (CDM) (TELEPHONE: 919-541-3419; FAX: (301) 480-3210; Mail Drop K2-05, NIEHS, P. O. BOX 12233,

Research Triangle Park, NC USA 27709; EMAIL: CDM@NIEHS.NIH.GOV) . All requests containing checks, money orders, or

purchase orders should be sent to NTIS.

Ref No. 16

Printed Long-Term and Short-Term Study Reports

Short-Term Studies

CARCINOGEN

CODES

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No. NTIS **

NUMBER

MR FR MM FM*+

Acetone 67-64-1 COSM/SYN WATER R2 M3 TOX-03 PB91-185975

Acrolein 107-02-8 PLAS/SYN GAV R2 M3 TOX-48 PB2008-109744

Allyl acetate 591-87-7 INTR/SYN GAV R2 M3 TOX-48 PB2008-109744

Allyl alcohol 107-18-6 INTR/SYN GAV R2 M3 TOX-48 PB2008-109744

Antimony potassium tartrate 28300-74-5 PEST/SYN IP/IJ R2 M3 TOX-11 PB93-149714

AZT + Isoniazid (AIDS Initiative) AZTISONIAZID PHAR/SYN GAV M3 AIDS-08 PB2012-102038

AZT + Pyrazinamide combination (AIDS

Initiative)

AZTZINAMIDE PHAR/SYN GAV M3 AIDS-05 PB2000-103878

AZT + Rifampin (AIDS Initiative) AZTRIFAMPIN PHAR GAV M3 AIDS-06 PB2001-104503

Benzophenone 119-61-9 PHAR/SYN FEED R2 M3 TOX-61 PB2000-106659

Benzyltrimethyl ammonium chloride 56-93-9 DYE GAV R2 M3 TOX-57 PB2000-104839

Benzyltrimethyl ammonium chloride 56-93-9 DYE GAV R2 M3 TOX-57 PB2000-104839

Black newsprint ink EMTDP-75 DYE/SYN SP R2 M2 TOX-17 PB93-131910

beta-Bromo-beta-nitrostyrene 7166-19-0 PEST/SYN GAV R2 M3 TOX-40 PB95-144531

Butanal oxime 110-69-0 PNT/SYN WATER R2 M3 TOX-69 PB2004-104001

1,4-Butanediol 110-63-4 INTR/SYN FEED TOX-54 PB97-108161

*+ MR = Male Rat, FR = Female Rat, MM = Male Mice, FM = Female Mice.

See Page 4 for explanation of Carcnogen Codes
Last Update: 09/18/2015 10:46 Management Status Report Page 36

Ref No. 16

Printed Long-Term and Short-Term Study Reports

Short-Term Studies

CARCINOGEN

CODES

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No. NTIS **

NUMBER

MR FR MM FM*+

2-Butoxyethanol (ethylene glycol monobutyl

ether)

111-76-2 INTR/SYN WATER R2 M3 TOX-26 PB94-118106

2-Butoxyethanol (ethylene glycol monobutyl

ether)

111-76-2 INTR/SYN WATER R2 TOX-26 PB94-118106

tert-Butyl alcohol 75-65-0 IND/SYN INHAL R2 M3 TOX-53 PB98-108905

p-tert-Butylcatechol 98-29-3 RUBR/SYN FEED R2 M3 TOX-70 PB2003-102289

p-tert-Butylcatechol 98-29-3 RUBR/SYN FEED R2 M3 TOX-70 PB2003-102289

tert-Butyl perbenzoate 614-45-9 ADHS/SYN GAV R2 M3 TOX-15 PB93-105690/AS

Cadmium oxide 1306-19-0 DYE/N/S INHAL R2 M3 TOX-39 PB95-263356

Cadmium oxide 1306-19-0 DYE/N/S INHAL R8 M5 TOX-39 PB95-263356

Carisoprodol 78-44-4 PHAR/SYN GAV R2 M3 TOX-56 PB2001-100477

Carisoprodol 78-44-4 PHAR/SYN GAV R2 M3 TOX-56 PB2001-100477

Castor oil 8001-79-4 COSM/NATL FEED R2 M3 TOX-12 PB93-151439

Cellulose insulation CELLULOSEINS PAPR/SYN IT R2 TOX-74 PB2009-115653

Chemical mixture - drinking water

contaminants

CHEMMIXH2O COMT/NATL WATER R2 M3 TOX-35 PB94-121498

Chloral hydrate 302-17-0 PHAR/SYN GAV R2 MV C92010B

m-Chloroaniline 108-42-9 INTR/SYN GAV R2 M3 TOX-43 PB98-135932

o-Chloroaniline 95-51-2 DYE/SYN GAV R2 M3 TOX-43 PB98-135932

2-Chloronitrobenzene 88-73-3 DYE/SYN INHAL R2 M3 TOX-33 PB94-118262

4-Chloronitrobenzene 100-00-5 DYE/SYN INHAL R2 M3 TOX-33 PB94-118262

1-Chloro-2-propanol, technical 127-00-4 INTR/SYN WATER R2 M3 TR-477 PB99-119240

p-Chloro-a,a,a-trifluorotoluene 98-56-6 SYN GAV R2 M3 TOX-14 PB93-105682/AS

p-Chloro-a,a,a-trifluorotoluene 98-56-6 SYN GAV R2 M3 TOX-14 PB93-105682/AS

C.I. Direct Black 38 1937-37-7 DYE FEED R2 M3 TR-108 PB280204 P P

C.I. Direct Blue 6 2602-46-2 COSM FEED R2 M3 TR-108 PB280204 P P

C.I. Direct Brown 95 16071-86-6 DYE FEED R2 M3 TR-108 PB280204 N P

Cobalt sulfate heptahydrate 10026-24-1 DYE/NATL INHAL R2 M3 TOX-05 PB91-185348

m-Cresol 108-39-4 FUME/NATL FEED R2 M3 TOX-09 PB92-174242

o-Cresol 95-48-7 DYE/NATL FEED R2 M3 TOX-09 PB92-174242

p-Cresol 106-44-5 PEST/NATL FEED R2 M3 TOX-09 PB92-174242

Cresols 1319-77-3 DYE/N/S FEED R2 M3 TOX-09 PB92-174242

Cupric sulfate 7758-99-8 FOOD/NATL WATER R2 M3 TOX-29 PB94-120870

Cupric sulfate 7758-99-8 FOOD/NATL FEED R2 M3 TOX-29 PB94-120870

Cyclohexanone oxime 100-64-1 PLAS/SYN WATER M3 TOX-50 PB96-175559

D&C Yellow No. 11 8003-22-3 COSM/SYN FEED R2 M3 TOX-08 PB91-185355

2,4-Decadienal 25152-84-5 FOOD/N/S GAV R2 M3 TOX-76 PB2011-105285

Diazoaminobenzene 136-35-6 DYE/SYN SP R2 M3 TOX-73 PB2003-103038

1,2-Dibromo-2,4-dicyanobutane 35691-65-7 FUNG/SYN SP R2 M3 TR-555 PB2010-113180

Dibutyl Phthalate 84-74-2 FUNG/SYN FEED R2 M3 TOX-30 PB95-232427

Dibutyl Phthalate 84-74-2 FUNG/SYN FEED R2 M3 TOX-30 PB95-232427

1,2-Dichloroethane 107-06-2 FUME/SYN GAV R2 TOX-04 PB91-185363

1,2-Dichloroethane 107-06-2 FUME/SYN WATER R2 M3 TOX-04 PB91-185363

1,2-Dichloroethane 107-06-2 FUME/SYN WATER R1 R8 TOX-04 PB91-185363

trans-1,2-Dichloroethylene 156-60-5 SOLV MICRO R2 M3 TOX-55 PB2002-108967

Diethanolamine 111-42-2 TEXL/SYN SP R2 M3 TOX-20 PB93-133999

Diethanolamine 111-42-2 TEXL/SYN WATER R2 M3 TOX-20 PB93-133999

Dimethylaminopropyl chloride, hydrochloride 5407-04-5 INTR/SYN GAV R2 M3 TOX-75 PB2009-114738

Dimethylformamide 68-12-2 SOLV/SYN INHAL R2 M3 TOX-22 PB93-131936

1,3-Diphenylguanidine 102-06-7 RUBR/SYN FEED R2 M3 TOX-42 PB96-115639

Estragole 140-67-0 FOOD/NATL GAV R2 M3 TOX-82 PB2011-105234

Ethylbenzene 100-41-4 FUEL/SYN INHAL R2 M3 TOX-10 PB93-149722

Ethylene glycol monoethyl ether (EGMEE) 110-80-5 COSM/SYN WATER R2 M3 TOX-26 PB94-118106

Ethylene glycol monoethyl ether (EGMEE) 110-80-5 COSM/SYN WATER R2 TOX-26 PB94-118106

Ethylene Glycol Monomethyl Ether (EGMME) 109-86-4 COSM/SYN WATER R2 M3 TOX-26 PB94-118106

Ethylene Glycol Monomethyl Ether (EGMME) 109-86-4 COSM/SYN WATER R2 TOX-26 PB94-118106

Formamide 75-12-7 SOLV/SYN GAV R2 M3 TR-541 PB2009-115393

Formic acid 64-18-6 FUME/N/S INHAL R2 M3 TOX-19 PB93-149730

Glutaraldehyde 111-30-8 ADHS/SYN INHAL R2 M3 TOX-25 PB94-119252

Glyphosate 1071-83-6 HERB/SYN FEED R2 M3 TOX-16 PB95-109898

Glyphosate 1071-83-6 HERB/SYN FEED R2 TOX-16 PB95-109898

Goldenseal root powder GOLDENSEALRT DIET/NATL FEED R2 M3 TR-562 PB2011-101388

Halogenated ethanes CS

(1,2-Dichloro-1,1-difluoroethane)

1649-08-7 IND/SYN GAV R2 TOX-45 PB96-202718

Halogenated ethanes CS

(1,2-Difluoro-1,1,2,2-tetrachloroethane)

76-12-0 SOLV/SYN GAV R2 TOX-45 PB96-202718

Halogenated ethanes CS (Hexachloroethane) 67-72-1 SOLV/SYN GAV R2 TOX-45 PB96-202718

Halogenated ethanes CS (Pentabromoethane) 75-95-6 IND/SYN GAV R2 TOX-45 PB96-202718

Halogenated ethanes CS (Pentachloroethane) 76-01-7 SOLV/SYN GAV R2 TOX-45 PB96-202718

Halogenated ethanes CS

(1,1,1,2-Tetrabromoethane)

630-16-0 IND/SYN GAV R2 TOX-45 PB96-202718

*+ MR = Male Rat, FR = Female Rat, MM = Male Mice, FM = Female Mice.

See Page 4 for explanation of Carcnogen Codes
Last Update: 09/18/2015 10:46 Management Status Report Page 37

Ref No. 16

Printed Long-Term and Short-Term Study Reports

Short-Term Studies

CARCINOGEN

CODES

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No. NTIS **

NUMBER

MR FR MM FM*+

Halogenated ethanes CS

(1,1,2,2-Tetrabromoethane)

79-27-6 FLAM/SYN GAV R2 TOX-45 PB96-202718

Halogenated ethanes CS

(1,1,1,2-Tetrachloroethane)

630-20-6 INTR GAV R2 TOX-45 PB96-202718

Halogenated ethanes CS

(1,1,2,2-Tetrachloroethane)

79-34-5 SOLV/SYN GAV R2 TOX-45 PB96-202718

Halogenated ethanes CS

(1,1,1-Trichloroethane)

71-55-6 SOLV/SYN GAV R2 TOX-45 PB96-202718

Halogenated ethanes CS

(1,1,1-Trichloro-2,2,2-trifluoroethane)

354-58-5 IND/SYN GAV R2 TOX-45 PB96-202718

Hexachloro-1,3-butadiene 87-68-3 FUME FEED M3 TOX-01 PB91-185884

1,6-Hexanediamine dihydrochloride 6055-52-3 INTR/SYN INHAL R2 M3 TOX-24 PB94-119260

1,6-Hexanediamine dihydrochloride 6055-52-3 INTR/SYN WATER R2 M3 TOX-24 PB94-119260

n-Hexane 110-54-3 NATL/NATL INHAL M3 TOX-02 PB91-185322

2-Hydroxy-4-methoxybenzophenone 131-57-7 COSM/SYN FEED R2 M3 TOX-21 PB93-126498

2-Hydroxy-4-methoxybenzophenone 131-57-7 COSM/SYN SP R2 M3 TOX-21 PB93-126498

2-Hydroxy-4-methoxybenzophenone 131-57-7 COSM/SYN SP R2 M3 TOX-21 PB93-126498

5-(Hydroxymethyl)-2-furfural 67-47-0 NATL/N/S GAV R2 M3 TR-554 PB2010-113179

Isoprene 78-79-5 RUBR/N/S INHAL R2 M3 TOX-31 PB95-226486

Isoprene 78-79-5 RUBR/N/S INHAL R2 M3 TOX-31 PB95-226486

Leucomalachite green 129-73-7 FUNG/SYN FEED R2 MV TOX-71 PB2004-106614

Magnetic fields (EMF) ELECTROMAG ELEC WB R2 M3 TOX-58 PB97-115463

Magnetic fields + DMBA initiation promotion EMF+DMBA ELEC/SYN GV/WB R8 TR-489 PB2000-101313

Malachite green 569-64-2 GERM/SYN FEED R2 MV TOX-71 PB2004-106614

Methacrylonitrile 126-98-7 INTR/SYN GAV R2 M3 TOX-47 PB2000-106-406

Methapyrilene hydrochloride 135-23-9 PHAR/SYN FEED R2 TOX-46 PB2000-107871

Methylene bis(thiocyanate) 6317-18-6 FUNG/SYN GAV R2 M3 TOX-32 PB94-194164

Methyl ethyl ketone peroxide 1338-23-4 PLAS/SYN SP R2 M3 TOX-18 PB94-119278

Methyl ethyl ketoxime 96-29-7 PNT WATER R2 M3 TOX-51 PB99-176828

2-Methylimidazole 693-98-1 INTR/N/S FEED R2 M3 TOX-67 PB2004-105393

4-Methylimidazole 822-36-6 FOOD/N/S FEED R2 M3 TOX-67 PB2004-105393

1-Nitropyrene 5522-43-0 ENVH/SYN INHAL R2 TOX-34 PB96-176342

m-Nitrotoluene 99-08-1 DYE/SYN FEED R2 M3 TOX-23 PB93-150092

o-Nitrotoluene 88-72-2 RUBR/SYN FEED R2 M3 TOX-23 PB93-150092

o-Nitrotoluene 88-72-2 RUBR/SYN FEED R2 TOX-44 PB96-188321

p-Nitrotoluene 99-99-0 DYE/SYN FEED R2 M3 TOX-23 PB93-150092

Pentachlorobenzene 608-93-5 FLAM FEED R2 M3 TOX-06 PB91-185983

Peroxisome project (WY-14643) 50892-23-4 PHAR/SYN FEED M3 H1

HSD

TOX-62 PB2000-106659

Pesticide/fertilizer contamination--mixture

2

PESTFERTMIX2 COMT/SYN WATER R2 M3 TOX-36 PB94-121035

Pesticide/fertilizer contamination--mixture

3

PESTFERTMIX3 COMT/SYN WATER R2 M3 TOX-36 PB94-121035

Riddelliine 23246-96-0 PHAR/NATL GAV R2 M3 TOX-27 PB94-194685

Senna (powdered) 8013-11-4 DIET/NATL FEED M1 GMM-15 PB2012111383

Senna (powdered) 8013-11-4 DIET/NATL FEED MD GMM-15 PB2012111383

Sodium cyanide 143-33-9 FUME/SYN WATER R2 M3 TOX-37 PB94-194693

Sodium dichromate dihydrate (VI) 7789-12-0 ENVH/SYN WATER M3 MW MX TOX-72 PB2007-107225

Sodium selenate 13410-01-0 FEED/SYN WATER R2 M3 TOX-38 PB94-215753

Sodium selenite 10102-18-8 FEED/SYN WATER R2 M3 TOX-38 PB94-215753

3,3',4,4'-Tetrachloroazobenzene 14047-09-7 PEST/SYN GAV R2 M3 TOX-65 PB99-123465

3,3',4,4'-Tetrachloroazobenzene 14047-09-7 PEST/SYN GAV HSD TR-558 PB2011-104500

3,3',4,4'-Tetrachloroazoxybenzene 21232-47-3 COMT/SYN GAV R2 M3 TOX-66 PB99-123663

1,2,4,5-Tetrachlorobenzene 95-94-3 DYE FEED R2 M3 TOX-07 PB91-185330

1,1,2,2-Tetrachloroethane 79-34-5 SOLV/SYN MICRO R2 M3 TOX-49 PB2004-105706

1,1,2,2-Tetrachloroethane 79-34-5 SOLV/SYN MICRO R2 M3 TOX-49 PB2004-105706

Tetrachlorophthalic anhydride 117-08-8 FLAM/SYN GAV R2 M3 TOX-28 PB94-119245

alpha-Thujone 546-80-5 DIET/NATL GAV R2 M3 TR-570 PB2012-102007

alpha/beta Thujone mixture 76231-76-0 COSM/NATL GAV R2 M3 TR-570 PB2012-102007

o-Toluidine hydrochloride 636-21-5 DYE FEED R2 TOX-44 PB96-188321

1,1,1-Trichloroethane 71-55-6 SOLV/SYN MICRO R2 M3 TOX-41 PB2001-100476

2,4,7-Trinitro-fluoren-9-one 129-79-3 PHOT/SYN SP R2 M3 TOX-13 PB92-238864/AS

2,4,7-Trinitro-fluoren-9-one 129-79-3 PHOT/SYN FEED R2 M3 TOX-13 PB92-238864/AS

Urethane 51-79-6 PNT/SYN WATER R2 M3 TOX-52 PB96-175575

Urethane + ethanol (combination) URETHCOMB PNT/N/S WATER R2 M3 TOX-52 PB96-175575

*+ MR = Male Rat, FR = Female Rat, MM = Male Mice, FM = Female Mice.

See Page 4 for explanation of Carcnogen Codes
Last Update: 09/18/2015 10:46 Management Status Report Page 38

Ref No. 16

Printed Long-Term and Short-Term Study Reports

Short-Term Studies in Support of Long-Term Studies

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES COMMENTS

Barium chloride dihydrate 10326-27-9 DYE/NATL WATER R2 M3 REPORTED IN TR-432

Benzethonium chloride 121-54-0 COSM/SYN SP R2 M3 REPORTED IN TR-438

o-Benzyl-p-chlorophenol 120-32-1 GERM/SYN GAV R2 M3 REPORTED IN TR-424

2,2-bis(Bromomethyl)-1,3-propanediol 3296-90-0 FLAM/SYN FEED R2 M3 REPORTED IN TR-452

Butyl benzyl phthalate 85-68-7 PLAS/SYN FEED R2 REPORTED IN TR-458

Chloroprene 126-99-8 PLAS/SYN INHAL R2 M3 REPORTED IN TR-467

C.I. Direct Blue 218 28407-37-6 DYE FEED R2 M3 REPORTED IN TR-430

Codeine 76-57-3 INTR/N/S FEED R2 M3 REPORTED IN TR-455

Coumarin 91-64-5 PHAR/NATL GAV R2 M3 REPORTED IN TR-422

p,p'-Dichlorodiphenyl sulfone 80-07-9 PLAS FEED R2 M3 REPORTED IN TR-501

3,4-Dihydrocoumarin 119-84-6 FOOD/NATL GAV R2 M3 REPORTED IN TR-423

1,2-Dihydro-2,2,4-trimethylquinoline

(monomer)

147-47-7 IND/SYN SP R2 M3 REPORTED IN TR-456

1,2-Dihydro-2,2,4-trimethylquinoline

(monomer)

147-47-7 IND/SYN SP R2 M7 REPORTED IN TR-456

Diisopropylcarbodiimide 693-13-0 INTR/SYN SP R2 M3 REPORTED IN TR-523

Dipropylene glycol 25265-71-8 INTR WATER R2 M3 REPORTED IN TR-511

Elmiron (sodium pentosanpolysulfate) 37319-17-8 PHAR/SYN GAV R2 M3 REPORTED IN TR-512

Fumonisin B1 116355-83-0 FEED/NATL FEED R2 M3 REPORTED IN TR-496

Furfuryl alcohol 98-00-0 FOOD/N/S INHAL R2 M3 REPORTED IN TR-482

Gallium arsenide 1303-00-0 ELEC/SYN INHAL R2 M3 REPORTED IN TR-492

2,4-Hexadienal 142-83-6 FOOD/N/S GAV R2 M3 REPORTED IN TR-509

Isobutyraldehyde 78-84-2 INTR/N/S INHAL R2 M3 REPORTED IN TR-472

Manganese sulfate monohydrate 10034-96-5 DYE/NATL FEED R2 M3 REPORTED IN TR-428

Methyl bromide 74-83-9 FUME/SYN INHAL R2 M3 REPORTED IN TR-385

Methyl bromide 74-83-9 FUME/SYN INHAL R2 M3 REPORTED IN TR-385

Methyleugenol 93-15-2 FOOD/NATL GAV R2 M3 REPORTED IN TR-491

Methylphenidate hydrochloride 298-59-9 PHAR/SYN FEED R2 M3 REPORTED IN TR-439

Molybdenum trioxide 1313-27-5 DYE/SYN INHAL R2 M3 REPORTED IN TR-462

p-Nitroaniline 100-01-6 DYE/SYN GAV M3 REPORTED IN TR-418

o-Nitroanisole 91-23-6 DYE/SYN FEED R2 M3 REPORTED IN TR-416

p-Nitrobenzoic acid 62-23-7 DYE FEED R2 M3 REPORTED IN TR-442

Pentachlorophenol, DP-2 87-86-5 PEST/SYN FEED M3 REPORTED IN TR-349

Pentachlorophenol, purified 87-86-5 PEST/SYN FEED M3 REPORTED IN TR-349

Phenolphthalein 77-09-8 PHAR/SYN FEED R2 M3 REPORTED IN TR-465

Promethazine hydrochloride 58-33-3 PHAR/SYN GAV R2 M3 REPORTED IN TR-425

Salicylazosulfapyridine 599-79-1 PHAR/SYN GAV R2 M3 REPORTED IN TR-457

Scopolamine hydrobromide trihydrate 6533-68-2 PHAR/SYN GAV R2 M3 REPORTED IN TR-445

Sodium nitrite 7632-00-0 INTR/SYN WATER R2 M3 REPORTED IN TR-495

Sodium xylenesulfonate 1300-72-7 DTRG/SYN SP R2 M3 REPORTED IN TR-464

Tetrafluoroethylene 116-14-3 FOOD/SYN INHAL R2 M3 REPORTED IN TR-450

1-trans-delta-9-Tetrahydrocannabinol 1972-08-3 PHAR/NATL GAV R2 M3 REPORTED IN TR-446

Tetrahydrofuran 109-99-9 FDPK/SYN INHAL R2 M3 REPORTED IN TR-475

Theophylline 58-55-9 PHAR/NATL GAV R2 M3 REPORTED IN TR-473

Theophylline 58-55-9 PHAR/NATL FEED R2 M3 REPORTED IN TR-473

Toluene 108-88-3 FUEL/N/S GAV R2 M3 REPORTED IN TR-371

Vanadium pentoxide 1314-62-1 INTR/NATL INHAL R2 M3 REPORTED IN TR-507

** The NCI and the NTP Technical Reports for the following chemicals are available from the National Technical

Information Service (NTIS), Department of Commerce, 5285 Port Royal Road, Springfield, Virginia 22161, Phone: (703)

605-6000 or 1-800-553-6847 (rush orders only). Technical reports numbered 220 or higher may also be available from

Central Data Management (CDM) (TELEPHONE: 919-541-3419; FAX: (301) 480-3210; Mail Drop K2-05, NIEHS, P. O. BOX 12233,

Research Triangle Park, NC USA 27709; EMAIL: CDM@NIEHS.NIH.GOV) . All requests containing checks, money orders, or

purchase orders should be sent to NTIS.

Ref No. 16

Printed Long-Term and Short-Term Study Reports

Long-Term Studies

CARCINOGEN

CODES

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No. NTIS **

NUMBER

MR FR MM FM*+

Acetaminophen (4-hydroxyacetanilide) 103-90-2 PHAR/SYN FEED R2 M3 TR-394 PB93-227478 NE EE NE NE

Acetohexamide 968-81-0 PHAR/SYN FEED R2 M3 TR-050 PB284673 N N N N

Acetonitrile 75-05-8 SOLV/SYN INHAL R2 M3 TR-447 PB96-214937 EE NE NE NE

Acronycine 7008-42-6 CMOT/NATL IP/IJ R8 M3 TR-049 PB283347 P P IS IS

Acrylamide 79-06-1 COMT/SYN WATER RC MV TR-575 PB2013102800 CE CE CE CE

Acrylonitrile 107-13-1 INTR/SYN GAV M3 TR-506 PB2002-102198 CE CE

Agar 9002-18-0 FOOD/NATL FEED R2 M3 TR-230 PB82-227588 N N N N

Aldicarb 116-06-3 PEST/SYN FEED R2 M3 TR-136 PB298511 N N N N

Aldrin 309-00-2 PEST/SYN FEED R1 M3 TR-021 PB275666 E E P P

Allyl chloride 107-05-1 INTR/SYN GAV R1 M3 TR-073 PB287516 N N E E

Allyl glycidyl ether 106-92-3 SOLV/SYN INHAL R1 M3 TR-376 PB90-260027 EE NE SE SE

*+ MR = Male Rat, FR = Female Rat, MM = Male Mice, FM = Female Mice.

See Page 4 for explanation of Carcnogen Codes
Last Update: 09/18/2015 10:46 Management Status Report Page 39

Ref No. 16

Printed Long-Term and Short-Term Study Reports

Long-Term Studies

CARCINOGEN

CODES

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No. NTIS **

NUMBER

MR FR MM FM*+

Allyl isothiocyanate 57-06-7 FOOD/NATL GAV R2 M3 TR-234 PB83-144238 P E N N

Allyl isovalerate 2835-39-4 FOOD/SYN GAV R2 M3 TR-253 PB83-218214 P N N N

Aloe-emodin 481-72-1 DIET/NATL SP MT TR-553 PB2011-101386

Aloe phototoxicity studies ALOEPHOTOTOX DIET/NATL SP MT TR-553 PB2011-101386

Aloe vera charcoal filtered whole leaf

extract

ALOEVFILTER DIET/NATL SP MT TR-553 PB2011-101386

Aloe vera gel 8001-97-6 DIET/NATL SP MT TR-553 PB2011-101386

Aloe vera whole leaf extract (native) ALOEVLEAFEXT DIET/NATL WATER RC MV TR-577 PB2014-100511 CE CE NE NE

Aloe vera whole leaf extract (native) ALOEVLEAFEXT DIET/NATL SP MT TR-553 PB2011-101386

alpha/beta Hydroxy acids (glycolic acid,

salicylic acid)

HYDROXGLYSAL COSM/N/S SP MT TR-524 PB2008109732 NE NE

2-Aminoanthraquinone 117-79-3 DYE/SYN FEED R2 M3 TR-144 PB287739 P IS P P

1-Amino-2,4-dibromoanthraquinone 81-49-2 DYE/SYN FEED R2 M3 TR-383 PB97-116636 CE CE CE CE

3-Amino-4-ethoxyacetanilide 17026-81-2 DYE FEED R2 M3 TR-112 PB285194 N N P P

3-Amino-9-ethylcarbazole HCl 6109-97-3 DYE FEED R2 M3 TR-093 PB287126 P P P P

1-Amino-2-methylanthraquinone 82-28-0 DYE/SYN FEED R2 M3 TR-111 PB286852 P P N N

2-Amino-4-nitrophenol 99-57-0 DYE/SYN GAV R2 M3 TR-339 PB89-128623 SE NE NE NE

2-Amino-5-nitrophenol 121-88-0 DYE/SYN GAV R2 M3 TR-334 PB88-184809 SE NE NE NE

4-Amino-2-nitrophenol 119-34-6 DYE/SYN FEED R2 M3 TR-094 PB286189 P E N N

2-Amino-5-nitrothiazole 121-66-4 PHAR/SYN FEED R2 M3 TR-053 PB283346 P N N N

11-Aminoundecanoic acid 2432-99-7 INTR/SYN FEED R2 M3 TR-216 PB82-225640 P N E E

DL-amphetamine sulfate 60-13-9 PHAR/SYN FEED R2 M3 TR-387 PB92-107978 NE NE NE NE

Ampicillin trihydrate 7177-48-2 PHAR/N/S GAV R2 M3 TR-318 PB87-204160 EE NE NE NE

Androstenedione 63-05-8 DIET/SYN GAV R2 M3 TR-560 PB2011-100790 EE EE CE CE

Anilazine 101-05-3 FUNG/SYN FEED R2 M3 TR-104 PB287141 N N N N

Aniline hydrochloride 142-04-1 DYE/NATL FEED R2 M3 TR-130 PB287539 P P N N

o-Anisidine hydrochloride 134-29-2 DYE FEED R2 M3 TR-089 PB285879 P P P P

p-Anisidine hydrochloride 20265-97-8 DYE FEED R2 M3 TR-116 PB286951 E N N N

o-Anthranilic acid 118-92-3 DYE/NATL FEED R2 M3 TR-036 PB278883 N N N N

Anthraquinone 84-65-1 DYE/SYN FEED R2 M3 TR-494 PB2006-101509 SE CE CE CE

Aroclor 1254 11097-69-1 ELEC FEED R2 TR-038 PB279624 E E

Asbestos, amosite 12172-73-5 NSUL/NATL FEED R2 TR-279 PB91-172312 N N

Asbestos, amosite 12172-73-5 NSUL/NATL FEED H1 TR-249 PB87-133278

Asbestos, amosite + Dimethyl hydrazine 12172-73-5 FLAM/NATL FEED R2 TR-279 PB91-172312 IS IS

Asbestos, chrysotile(IR) 12001-29-5 TEXL/NATL FEED R2 TR-295 PB86-167103 SE NE

Asbestos, chrysotile(IR) 12001-29-5 TEXL/NATL FEED H1 TR-246 PB91-142380

Asbestos, chrysotile(IR) 12001-29-5 TEXL/NATL FEED R2 TR-295 PB86-167103

Asbestos, chrysotile(IR) + Dimethyl

hydrazine

12001-29-5 TEXL/NATL FEED H1 TR-246 PB91-142380

Asbestos, chrysotile(IR) + Dimethyl

hydrazine

12001-29-5 TEXL/NATL FEED R2 TR-295 PB86-167103 IS IS

Asbestos, chrysotile(SR) 12001-29-5 TEXL/NATL FEED R2 TR-295 PB86-167103 NE NE

Asbestos, chrysotile(SR) 12001-29-5 TEXL/NATL FEED H1 TR-246 PB91-142380

Asbestos, crocidolite 12001-28-4 NSUL/NATL FEED R2 TR-280 PB89-178529 N N

L-Ascorbic acid 50-81-7 COSM/NATL FEED R2 M3 TR-247 PB83-201194 N N N N

Aspirin, phenacetin, and caffeine 8003-03-0 PHAR/N/S FEED R2 M3 TR-067 PB284684 N E N N

5-Azacytidine 320-67-2 CMOT/SYN IP/IJ R8 M3 TR-042 PB279526 IS IS IS IS

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 CMOT/SYN GAV M3 MV TR-569 PB2013-104938 NE NE

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 CMOT/SYN GAV MV TR-569 PB2013-104938 NE NE

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 CMOT/SYN GAV MV TR-569 PB2013-104938 SE SE

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 CMOT/SYN GAV MV TR-569 PB2013-104938 NE NE

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 CMOT/SYN GAV MJ GMM-14 PB2014-103470 CE CE

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 CMOT/SYN GAV MS GMM-16 PB2014-103469 CE CE

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 CMOT/SYN GAV MS GMM-16 PB2014-103469 NE NE

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 CMOT/SYN GAV MS GMM-16 PB2014-103469 NE NE

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 CMOT/SYN GAV MS GMM-16 PB2014-103469 CE CE

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 CMOT/SYN GAV MS GMM-16 PB2014-103469 CE CE

3'-Azido-3'-deoxythymidine (AIDS) 30516-87-1 CMOT/SYN GAV R2 M3 TR-469 PB99-145807 EE EE

Azinphosmethyl 86-50-0 PEST/SYN FEED R1 M3 TR-069 PB286371 E N N N

Azobenzene 103-33-3 DYE/SYN FEED R2 M3 TR-154 PB293835 P P N N

AZT+3TC+NVP combination AZT3TCCOMBO PHAR/SYN GAV MJ GMM-16 PB2014-103469

AZT/Drug Combinations Transplacental

Carcinogenesis Study

AIDSTHERAPEU PHAR/SYN UTERO MV

AZT transplacental carcinogenesis study 30516-87-1 CMOT/SYN UTERO M5 TR-522 PB2006-115448 CE CE

Barium chloride dihydrate 10326-27-9 DYE/NATL WATER R2 M3 TR-432 PB94-214178 NE NE NE NE

Benzaldehyde 100-52-7 INTR/N/S GAV R2 M3 TR-378 PB90-253782 NE NE SE SE

Benzene 71-43-2 COMT/N/S GAV R2 M3 TR-289 PB86-216967 CE CE CE CE

Benzethonium chloride 121-54-0 COSM/SYN SP R2 M3 TR-438 PB96-162300 NE NE NE NE

Benzofuran 271-89-6 INTR/SYN GAV R2 M3 TR-370 PB90-231127 NE SE CE CE

Benzoin 119-53-9 FOOD/SYN FEED R2 M3 TR-204 PB80-217953 N N N N

Benzophenone 119-61-9 PHAR/SYN FEED R2 M3 TR-533 PB2006-111481 SE EE SE SE

*+ MR = Male Rat, FR = Female Rat, MM = Male Mice, FM = Female Mice.

See Page 4 for explanation of Carcnogen Codes
Last Update: 09/18/2015 10:46 Management Status Report Page 40

Ref No. 16

Printed Long-Term and Short-Term Study Reports

Long-Term Studies

CARCINOGEN

CODES

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No. NTIS **

NUMBER

MR FR MM FM*+

p-Benzoquinone dioxime 105-11-3 RUBR/SYN FEED R2 M3 TR-179 PB291501 N P N N

1,2,3-Benzotriazole 95-14-7 INTR/SYN FEED R2 M3 TR-088 PB285202 E E N N

Benzyl acetate 140-11-4 COSM/N/S GAV R2 M3 TR-250 PB87-115044 EE NE SE SE

Benzyl acetate 140-11-4 COSM/N/S FEED R2 M3 TR-431 PB94-184033 NE NE NE NE

Benzyl alcohol 100-51-6 COSM/NATL GAV R2 M3 TR-343 PB90-110206 NE NE NE NE

o-Benzyl-p-chlorophenol 120-32-1 GERM/SYN SP M5 TR-444 PB96-162342

o-Benzyl-p-chlorophenol 120-32-1 GERM/SYN GAV R2 M3 TR-424 PB94-214202 NE EE SE SE

2-Biphenylamine hydrochloride 2185-92-4 DYE/SYN FEED R2 M3 TR-233 PB83-138842 N N E E

2,2-bis(Bromomethyl)-1,3-propanediol 3296-90-0 FLAM/SYN FEED R2 M3 TR-452 PB97-120224 CE CE CE CE

bis(2-Chloro-1-methylethyl) ether 108-60-1 SOLV/SYN GAV R2 TR-191 PB299741 N N

bis(2-Chloro-1-methylethyl) ether 108-60-1 SOLV/SYN GAV M3 TR-239 PB83-169615 P P

Bisphenol A 80-05-7 INTR/SYN FEED R2 M3 TR-215 PB82-184060 E E E E

Boric acid 10043-35-3 COSM/NATL FEED M3 TR-324 PB88-213475 NE NE

Bromodichloromethane 75-27-4 INTR/SYN GAV R2 M3 TR-321 PB88-168687 CE CE CE CE

Bromoethane (ethyl bromide) 74-96-4 INTR/SYN INHAL R2 M3 TR-363 PB90-219445 SE EE EE EE

1-Bromopropane 106-94-5 ADHS/SYN INHAL R2 M3 TR-564 PB2011-114187 SE CE NE NE

1,3-Butadiene 106-99-0 INTR/N/S INHAL M3 TR-288 PB85-179646 CE CE

1,3-Butadiene 106-99-0 INTR/N/S INHAL M3 TR-434 PB94-101631 CE CE

2-Butoxyethanol (ethylene glycol monobutyl

ether)

111-76-2 INTR/SYN INHAL R2 M3 TR-484 PB2000-105865 NE EE SE SE

tert-Butyl alcohol 75-65-0 IND/SYN WATER R2 M3 TR-436 PB96-162748 SE NE EE EE

Butylated hydroxytoluene 128-37-0 FOOD/SYN FEED R2 M3 TR-150 PB298539 N N N N

Butyl benzyl phthalate 85-68-7 PLAS/SYN FEED R2 M3 TR-213 PB83-118398 IS P N N

Butyl benzyl phthalate 85-68-7 PLAS/SYN FEED R2 TR-458 PB98-131089 SE EE

n-Butyl chloride 109-69-3 INTR/SYN GAV R2 M3 TR-312 PB86-218526 NE NE NE NE

t-Butylhydroquinone 1948-33-0 COSM FEED R2 M3 TR-459 PB98-107170 NE NE NE NE

gamma-Butyrolactone 96-48-0 INTR/SYN GAV R2 M3 TR-406 PB92-189323 NE NE EE EE

Calcium cyanamide 156-62-7 PEST/SYN FEED R2 M3 TR-163 PB293625 N N N N

Caprolactam 105-60-2 TEXL/SYN FEED R2 M3 TR-214 PB82-190182 N N N N

Captan 133-06-2 FUNG/SYN FEED R1 M3 TR-015 PB273475 N N P P

Carbromal 77-65-6 PHAR/SYN FEED R2 M3 TR-173 PB290130 N N N N

D-Carvone 2244-16-8 COSM/NATL GAV R2 M3 TR-381 PB90-241100 NE NE

Chloral hydrate 302-17-0 PHAR/SYN GAV R2 MV TR-502 PB2002-105712

Chloral hydrate 302-17-0 PHAR/SYN GAV MV TR-503 PB2003-103039 SE SE

Chloramben 133-90-4 HERB/SYN FEED R1 M3 TR-025 PB273065 N N E E

Chloraminated water CHLORAMINEMX WATR/SYN WATER R2 M3 TR-392 PB92-191659 NE EE NE NE

Chlordane (analytical grade) 57-74-9 PEST/SYN FEED R1 M3 TR-008 PB271977 N N P P

Chlordecone 143-50-0 FUNG/SYN FEED R1 M3 TR-000

(143-50-0)

PB264041 P P P P

Chlorendic acid 115-28-6 FLAM/SYN FEED R2 M3 TR-304 PB87-206835 CE CE CE CE

Chlorinated paraffins: C12, 60% chlorine 108171-26-2 FLAM/SYN GAV R2 M3 TR-308 PB86-248101 CE CE CE CE

Chlorinated paraffins: C23, 43% chlorine 108171-27-3 FLAM/SYN GAV R2 M3 TR-305 PB86-248093 NE EE CE CE

Chlorinated trisodium phosphate 56802-99-4 DTRG GAV R2 M3 TR-294 PB87-189718 IS IS NE NE

Chlorinated water CHLORWATERMX WATR/SYN WATER R2 M3 TR-392 PB92-191659 NE EE NE NE

2-Chloroacetophenone (CN) 532-27-4 MLTR/SYN INHAL R2 M3 TR-379 PB90-256066 NE EE NE NE

4-(Chloroacetyl)acetanilide 140-49-8 DYE/SYN FEED R2 M3 TR-177 PB288754 N N N N

p-Chloroaniline 106-47-8 DYE/SYN FEED R2 M3 TR-189 PB295896 E N E E

p-Chloroaniline hydrochloride 20265-96-7 DYE GAV R2 M3 TR-351 PB90-222563 CE EE SE SE

o-Chlorobenzalmalononitrile (CS) 2698-41-1 MLTR/SYN INHAL R2 M3 TR-377 PB90-256280 NE NE NE NE

Chlorobenzene 108-90-7 COSM GAV R2 M3 TR-261 PB86-144714 E N N N

Chlorobenzilate 510-15-6 PEST/SYN FEED R1 M3 TR-075 PB287123 E E P P

Chlorodibromomethane 124-48-1 LABC/NATL GAV R2 M3 TR-282 PB86-166675 NE NE EE EE

Chloroethane 75-00-3 INTR/SYN INHAL R2 M3 TR-346 PB90-225053 EE EE IS IS

2-Chloroethanol (ethylene chlorohydrin) 107-07-3 SOLV/SYN SP R2 M4 TR-275 PB86-145513 NE NE NE NE

bis(2-Chloroethoxy)methane 111-91-1 SOLV/SYN SP R2 M3 TR-536 PB2011-113465 NE NE NE NE

2-Chloroethyltrimethylammonium chloride 999-81-5 FOOD/SYN FEED R2 M3 TR-158 PB293627 N N N N

Chloroform 67-66-3 SOLV/SYN GAV R1 M3 TR-000

(67-66-3)

PB264018 P N P P

3-Chloro-2-methylpropene 563-47-3 FUME/SYN GAV R2 M3 TR-300 PB86-247293 CE CE CE CE

2-Chloromethylpyridine hydrochloride 6959-47-3 INTR/SYN GAV R2 M3 TR-178 PB295895 N N N N

3-Chloromethylpyridine hydrochloride 6959-48-4 INTR GAV R2 M3 TR-095 PB287125 P E P P

4-Chloro-m-phenylenediamine 5131-60-2 COSM/SYN FEED R2 M3 TR-085 PB285201 P N N N

4-Chloro-o-phenylenediamine 95-83-0 DYE/SYN FEED R2 M3 TR-063 PB283362 P P P P

2-Chloro-p-phenylenediamine sulfate 61702-44-1 DYE/SYN FEED R2 M3 TR-113 PB286370 N N N N

Chloropicrin 76-06-2 PEST/SYN GAV R1 M3 TR-065 PB282311 I I N N

Chloroprene 126-99-8 PLAS/SYN INHAL R2 M3 TR-467 PB99-123671 CE CE CE CE

1-Chloro-2-propanol, technical 127-00-4 INTR/SYN WATER R2 M3 TR-477 PB99-119240 NE NE NE NE

Chlorothalonil 1897-45-6 PEST/SYN FEED R1 M3 TR-041 PB286369 P P N N

3-Chloro-p-toluidine 95-74-9 DYE/SYN FEED R2 M3 TR-145 PB287401 N N N N

5-Chloro-o-toluidine 95-79-4 INTR/SYN FEED R2 M3 TR-187 PB291468 N N P P

4-Chloro-o-toluidine hydrochloride 3165-93-3 INTR/SYN FEED R2 M3 TR-165 PB295864 N N P P

*+ MR = Male Rat, FR = Female Rat, MM = Male Mice, FM = Female Mice.

See Page 4 for explanation of Carcnogen Codes
Last Update: 09/18/2015 10:46 Management Status Report Page 41

Ref No. 16

Printed Long-Term and Short-Term Study Reports

Long-Term Studies

CARCINOGEN

CODES

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No. NTIS **

NUMBER

MR FR MM FM*+

Chlorpheniramine maleate 113-92-8 PHAR/SYN GAV R2 M3 TR-317 PB87-146759 NE NE NE NE

Chlorpropamide 94-20-2 PHAR/SYN FEED R2 M3 TR-045 PB275178 N N N N

Chromium picolinate monohydrate 27882-76-4 DIET/SYN FEED R2 M3 TR-556 PB2010-115374 EE NE NE NE

C.I. Acid Orange 3 6373-74-6 DYE/SYN GAV R2 M3 TR-335 PB89-216550 NE CE NE NE

C.I. Acid Orange 10 1936-15-8 DYE/SYN FEED R2 M3 TR-211 PB88-169347 N N N N

C.I. Acid Red 14 3567-69-9 DYE/SYN FEED R2 M3 TR-220 PB82-201468 N N N N

C.I. Acid Red 114 6459-94-5 DYE WATER R2 TR-405 PB92-189380 CE CE

C.I. Basic Red 9 Monohydrochloride 569-61-9 DYE/SYN FEED R2 M3 TR-285 PB86-186509 CE CE CE CE

C.I. Direct Blue 15 2429-74-5 DYE WATER R2 TR-397 PB93-126373 CE CE

C.I. Direct Blue 218 28407-37-6 DYE FEED R2 M3 TR-430 PB94-215993 SE NE CE CE

C.I. Disperse Blue 1 2475-45-8 DYE/SYN FEED R2 M3 TR-299 PB86-248051 CE CE EE EE

C.I. Disperse Yellow 3 2832-40-8 DYE FEED R2 M3 TR-222 PB82-230061 P N N N

trans-Cinnamaldehyde 14371-10-9 FOOD/NATL MICRO R2 M3 TR-514 PB2004-104394 NE NE NE NE

Cinnamyl anthranilate 87-29-6 FOOD/SYN FEED R2 M3 TR-196 PB81-143141 P N P P

C.I. Pigment Red 3 2425-85-6 DYE FEED R2 M3 TR-407 PB92-191634 SE SE SE SE

C.I. Pigment Red 23 6471-49-4 DYE FEED R2 M3 TR-411 PB93-228435 EE NE NE NE

C.I. Solvent Yellow 14 842-07-9 DYE/SYN FEED R2 M3 TR-226 PB83-126474 P P N N

Citral 5392-40-5 FOOD/NATL MICRO R2 M3 TR-505 PB2003-103040 NE NE NE NE

C.I. Vat Yellow 4 128-66-5 DYE FEED R2 M3 TR-134 PB288821 N N P P

Clonitralid 1420-04-8 PEST FEED R1 M3 TR-091 PB287124 N E IS IS

Cobalt 7440-48-4 IND/NATL INHAL R2 RD M3 TR-581 PB2015-101829 CE CE CE CE

Cobalt sulfate heptahydrate 10026-24-1 DYE/NATL INHAL R2 M3 TR-471 PB99-106627 SE CE CE CE

Coconut oil acid diethanolamine condensate 68603-42-9 TEXL/N/S SP R2 M3 TR-479 PB2001-103205 NE EE CE CE

Codeine 76-57-3 INTR/N/S FEED R2 M3 TR-455 PB97-116743 NE NE NE NE

Corn oil 8001-30-7 FOOD/NATL GAV R2 TR-426 PB95-103958

Coumaphos 56-72-4 PEST/SYN FEED R2 M3 TR-096 PB290305 N N N N

Coumarin 91-64-5 PHAR/NATL GAV R2 M3 TR-422 PB94-215761 SE EE SE SE

m-Cresidine 102-50-1 DYE GAV R2 M3 TR-105 PB286188 P P IS IS

p-Cresidine 120-71-8 DYE FEED R2 M3 TR-142 PB295835 P P P P

Cresols 1319-77-3 DYE/N/S FEED R2 M3 TR-550 PB2008-114135 EE

Cumene 98-82-8 ENVH/N/S INHAL R2 M3 TR-542 PB2009-115394 CE SE CE CE

Cupferron 135-20-6 REAG/SYN FEED R2 M3 TR-100 PB287409 P P P P

Cytembena 21739-91-3 CMOT/SYN IP/IJ R2 M3 TR-207 PB82-163312 P P N N

Daminozide 1596-84-5 HERB/SYN FEED R2 M3 TR-083 PB285073 N P E E

D&C Red No. 9 5160-02-1 DYE/SYN FEED R2 M3 TR-225 PB82-229592 P E N N

D&C Yellow No. 11 8003-22-3 COSM/SYN FEED R2 TR-463 PB97-107154 SE SE

Decabromodiphenyl ether 1163-19-5 FLAM FEED R2 M3 TR-309 PB86-247780 SE SE EE EE

Decalin 91-17-8 LABC/SYN INHAL RB R2 M3 TR-513 PB2005-107379 CE NE NE NE

Diallyl phthalate 131-17-9 PLAS GAV M3 TR-242 PB83-200824 E E

Diallyl phthalate 131-17-9 PLAS GAV R2 TR-284 PB86-203742 NE EE

4,4'-Diamino-2,2'-stilbenedisulfonic acid,

disodium salt

7336-20-1 DYE/SYN FEED R2 M3 TR-412 PB93-132504 NE NE NE NE

2,4-Diaminoanisole sulfate 39156-41-7 DYE/SYN FEED R2 M3 TR-084 PB279940 P P P P

2,4-Diaminophenol dihydrochloride 137-09-7 PHOT/SYN GAV R2 M3 TR-401 PB93-117919 NE NE SE SE

2,4-Diaminotoluene (2,4-toluene diamine) 95-80-7 DYE/SYN FEED R2 M3 TR-162 PB293593 P P N N

Diarylanilide yellow 6358-85-6 DYE FEED R2 M3 TR-030 PB278272 N N N N

Diazinon 333-41-5 PEST/SYN FEED R2 M3 TR-137 PB293889 N N N N

Dibenzo-p-dioxin 262-12-4 COMT/SYN FEED R1 M3 TR-122 PB288475 N N N N

1,2-Dibromo-3-chloropropane 96-12-8 FUME/SYN GAV R1 M3 TR-028 PB277472 P P P P

1,2-Dibromo-3-chloropropane 96-12-8 FUME/SYN INHAL R2 M3 TR-206 PB82-225632 P P P P

1,2-Dibromo-2,4-dicyanobutane 35691-65-7 FUNG/SYN SP R2 M3 TR-555 PB2010-113180 NE NE NE NE

1,2-Dibromoethane 106-93-4 PEST/SYN GAV R1 M3 TR-086 PB288428 P P P P

1,2-Dibromoethane 106-93-4 PEST/SYN INHAL R2 M3 TR-210 PB82-181710 P P P P

2,3-Dibromo-1-propanol 96-13-9 FLAM/SYN SP R2 M3 TR-400 PB94-206687 CE CE CE CE

Dibutyltin diacetate 1067-33-0 INTR/SYN FEED R2 M3 TR-183 PB291567 N IS N N

1,2-Dichlorobenzene (o-dichlorobenzene) 95-50-1 PEST/SYN GAV R2 M3 TR-255 PB86-144888 N N N N

1,4-Dichlorobenzene (p-dichlorobenzene) 106-46-7 PEST/SYN GAV R2 M3 TR-319 PB87-208617 CE NE CE CE

2,7-Dichlorodibenzo-p-dioxin 33857-26-0 GERM/SYN FEED R1 M3 TR-123 PB290570 N N E E

p,p'-Dichlorodiphenyl dichloroethylene 72-55-9 ENVH/SYN FEED R1 M3 TR-131 PB286367 N N P P

p,p'-Dichlorodiphenyl sulfone 80-07-9 PLAS FEED R2 M3 TR-501 PB2002-100580 NE NE NE NE

Dichlorodiphenyltrichloroethane (DDT) 50-29-3 ENVH/SYN FEED R1 M3 TR-131 PB286367 N N N N

1,1-Dichloroethane 75-34-3 SOLV/SYN GAV R1 M3 TR-066 PB283345 N E N N

1,2-Dichloroethane 107-06-2 FUME/SYN GAV R1 M3 TR-055 PB285968 P P P P

2,4-Dichlorophenol 120-83-2 ENVH/SYN FEED R2 M3 TR-353 PB90-106170 NE NE NE NE

2,6-Dichloro-p-phenylenediamine 609-20-1 INTR FEED R2 M3 TR-219 PB82-184052 N N P P

1,2-Dichloropropane (propylene dichloride) 78-87-5 FUEL/SYN GAV R2 M3 TR-263 PB87-114443 NE EE SE SE

1,3-Dichloropropene (Telone II) 542-75-6 PEST/SYN GAV R2 M3 TR-269 PB85-230449 CE SE IS IS

Dichlorvos 62-73-7 PEST/SYN FEED R1 M3 TR-010 PB270937 N N N N

Dichlorvos 62-73-7 PEST/SYN GAV R2 M3 TR-342 PB90-198508 SE EE SE SE

Dicofol 115-32-2 PEST/SYN FEED R1 M3 TR-090 PB286206 N N P P

N,N'-Dicyclohexylthiourea 1212-29-9 REAG FEED R2 M3 TR-056 PB281539 N N N N

*+ MR = Male Rat, FR = Female Rat, MM = Male Mice, FM = Female Mice.

See Page 4 for explanation of Carcnogen Codes
Last Update: 09/18/2015 10:46 Management Status Report Page 42

Ref No. 16

Printed Long-Term and Short-Term Study Reports

Long-Term Studies

CARCINOGEN

CODES

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No. NTIS **

NUMBER

MR FR MM FM*+

Dieldrin 60-57-1 PEST/SYN FEED R1 M3 TR-021 PB275666 N N E E

Dieldrin 60-57-1 PEST/SYN FEED R2 TR-022 PB275676 N N

Diesel fuel marine DIESELFUEL FUEL/N/S SP M3 TR-310 PB87-131678 EE EE

Diethanolamine 111-42-2 TEXL/SYN SP R2 M3 TR-478 PB99-167553 NE NE CE CE

Diethylamine 109-89-7 INTR/N/S INHAL R2 M3 TR-566 PB2012-101985 NE NE NE NE

Di(2-ethylhexyl)adipate 103-23-1 PLAS/SYN FEED R2 M3 TR-212 PB82-185927 N N P P

Di(2-ethylhexyl) Phthalate 117-81-7 PLAS/SYN FEED R2 M3 TR-217 PB82-184011 P P P P

Di(p-ethylphenyl)dichloroethane 72-56-0 PEST/SYN FEED R2 M3 TR-156 PB290582 N N N N

Diethyl phthalate 84-66-2 COSM SP R2 M3 TR-429 PB96-162276 NE NE EE EE

Diethyl phthalate/dimethyl phthalate DIETH/

DIMETH

COSM SP M5 TR-429 PB96-162276

N,N'-Diethylthiourea 105-55-5 METL/SYN FEED R2 M3 TR-149 PB288626 P P N N

Diglycidyl resorcinol ether (DGRE) 101-90-6 ADHS/NATL GAV R2 M3 TR-257 PB87-146734 P P P P

3,4-Dihydrocoumarin 119-84-6 FOOD/NATL GAV R2 M3 TR-423 PB95-103925 SE NE NE NE

1,2-Dihydro-2,2,4-trimethylquinoline

(monomer)

147-47-7 IND/SYN SP R2 M3 M7 TR-456 PB98-101009 SE NE NE NE

1,2-Dihydro-2,2,4-trimethylquinoline

(monomer)

147-47-7 IND/SYN SP R2 M3 TR-456 PB98-101009

Diisopropylcarbodiimide 693-13-0 INTR/SYN SP R2 M3 TR-523 PB2007107705 NE NE NE NE

Dimethoate 60-51-5 PEST/SYN FEED R1 M3 TR-004 PB264367 N N N N

Dimethoxane 828-00-2 PNT/SYN GAV R2 M3 TR-354 PB90-220096 NE NE EE EE

2,4-Dimethoxyaniline hydrochloride 54150-69-5 DYE FEED R2 M3 TR-171 PB288625 N N N N

3,3'-Dimethoxybenzidine dihydrochloride 20325-40-0 DYE WATER R2 TR-372 PB90-241076 CE CE

3,3'-Dimethoxybenzidine-4,4'-diisocyanate 91-93-0 INTR/SYN FEED R2 M3 TR-128 PB290154 P P N N

N,N-Dimethylaniline 121-69-7 DYE/SYN GAV R2 M3 TR-360 PB90-227240 SE NE NE NE

3,3'-Dimethylbenzidine dihydrochloride 612-82-8 DYE WATER R2 TR-390 PB92-103779 CE CE

Dimethyl hydrogen phosphite 868-85-9 FLAM/SYN GAV R2 M3 TR-287 PB86-144805 CE EE NE NE

Dimethyl methylphosphonate 756-79-6 FLAM/SYN GAV R2 M3 TR-323 PB88-168695 SE NE IS IS

Dimethyl morpholinophosphoramidate 597-25-1 MLTR GAV R2 M3 TR-298 PB86-186491 SE SE NE NE

Dimethyl terephthalate 120-61-6 TEXL/SYN FEED R2 M3 TR-121 PB299903 N N E E

N,N-Dimethyl-p-toluidine 99-97-8 INTR/SYN GAV R2 M3 TR-579 PB2013-101130 CE CE CE CE

Dimethylvinyl chloride (DMVC) 513-37-1 INTR/SYN GAV R2 M3 TR-316 PB87-115184 CE CE CE CE

2,4-Dinitrotoluene 121-14-2 DYE/SYN FEED R2 M3 TR-054 PB280990 P P N N

1,4-Dioxane 123-91-1 DYE/SYN WATER R1 M3 TR-080 PB285711 P P P P

Dioxathion 78-34-2 PEST/SYN FEED R1 M3 TR-125 PB286185 N N N N

Diphenhydramine hydrochloride 147-24-0 PHAR/SYN FEED R2 M3 TR-355 PB90-219437 EE EE NE NE

5,5-Diphenylhydantoin (phenytoin) 57-41-0 PHAR/SYN FEED R2 M3 TR-404 PB94-216009 EE NE NE NE

Dipropylene glycol 25265-71-8 INTR WATER R2 M3 TR-511 PB2005100832 NE NE NE NE

2,5-Dithiobiurea 142-46-1 PHOT/SYN FEED R2 M3 TR-132 PB291535 N N N N

Divinylbenzene 1321-74-0 PLAS INHAL R2 M3 TR-534 PB2007-103745 EE NE NE NE

Doxylamine 469-21-6 PHAR/SYN FEED R2 M3 NR-406/407

Elmiron (sodium pentosanpolysulfate) 37319-17-8 PHAR/SYN GAV R2 M3 TR-512 PB2004-106612 NE NE SE SE

Emetine hydrochloride 316-42-7 CMOT/NATL IP/IJ R8 M3 TR-043 PB278891 IS IS IS IS

Emodin 518-82-1 PHAR/NATL FEED R2 M3 TR-493 PB2001-108194 NE EE EE EE

Endocrine disruptor (Ethinyl estradiol) 57-63-6 PHAR/N/S FEED R8 TR-548 PB2011-100789 NE NE

Endocrine disruptor (Ethinyl estradiol) 57-63-6 PHAR/N/S FEED HSD TR-548 PB2011-100789 NE EE

Endocrine disruptor (Ethinyl estradiol) 57-63-6 PHAR/N/S FEED HSD TR-548 PB2011-100789 EE EE

Endocrine disruptor (Genistein) 446-72-0 NATL/NATL FEED R8 TR-545 PB2008-114279

Endosulfan 115-29-7 PEST/SYN FEED R1 M3 TR-062 PB281731 IS N IS IS

Endrin 72-20-8 PEST/SYN FEED R1 M3 TR-012 PB288461 N N N N

Ephedrine sulfate 134-72-5 PHAR/N/S FEED R2 M3 TR-307 PB86-247285 NE NE NE NE

Epinephrine hydrochloride 55-31-2 PHAR/NATL INHAL R2 M3 TR-380 PB91-142323 IS IS IS IS

1,2-Epoxybutane 106-88-7 FUEL/SYN INHAL R2 M3 TR-329 PB88-216262 CE EE NE NE

Erythromycin stearate 643-22-1 PHAR/NATL FEED R2 M3 TR-338 PB89-178537 NE NE NE NE

Estradiol mustard 22966-79-6 CMOT GAV R8 M3 TR-059 PB285787 N N P P

Ethanol 64-17-5 PHAR/N/S WATER MV TR-510 PB2005-103486 IS IS

Ethionamide 536-33-4 CMOT/SYN FEED R2 M3 TR-046 PB285193 N N N N

Ethyl acrylate 140-88-5 COSM/SYN GAV R2 M3 TR-259 PB87-204061 P P P P

Ethylbenzene 100-41-4 FUEL/SYN INHAL R2 M3 TR-466 PB99-134694 CE SE SE SE

Ethylene glycol 107-21-1 TEXL/SYN FEED M3 TR-413 PB93-228427 NE NE

Ethylene oxide 75-21-8 FUME/SYN INHAL M3 TR-326 PB88-169859 CE CE

Ethylene thiourea (ETU) 96-45-7 PEST/SYN FEED R2 M3 TR-388 PB92-191618 CE CE CE CE

Ethyl tellurac 20941-65-5 RUBR/SYN FEED R2 M3 TR-152 PB298513 E N E E

Eugenol 97-53-0 PHAR/NATL FEED R2 M3 TR-223 PB84-186402 N N E E

FD & C Yellow No. 6 2783-94-0 DYE/SYN FEED R2 M3 TR-208 PB82-117433 N N N N

Feed restriction studies FEEDRESTRICT FEED MULTI R2 M3 TR-460 PB98-131014

Formulated fenaminosulf 140-56-7 FUNG FEED R2 M3 TR-101 PB287443 N N N N

Fenthion 55-38-9 PEST/SYN FEED R2 M3 TR-103 PB293832 N N E E

Fish project 1

(2,2-bis(Bromomethyl)-1,3-propanediol)

3296-90-0 FLAM AQUAT F1 TR-528 PB 2006-102382

*+ MR = Male Rat, FR = Female Rat, MM = Male Mice, FM = Female Mice.

See Page 4 for explanation of Carcnogen Codes
Last Update: 09/18/2015 10:46 Management Status Report Page 43

Ref No. 16

Printed Long-Term and Short-Term Study Reports

Long-Term Studies

CARCINOGEN

CODES

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No. NTIS **

NUMBER

MR FR MM FM*+

Fish project 1

(2,2-bis(Bromomethyl)-1,3-propanediol)

3296-90-0 FLAM AQUAT F2 TR-528 PB 2006-102382

Fish Project 1 (Nitromethane) 75-52-5 FUEL AQUAT F1 TR-528 PB 2006-102382

Fish Project 1 (Nitromethane) 75-52-5 FUEL AQUAT F2 TR-528 PB 2006-102382

Fish project 1 (1,2,3-Trichloropropane) 96-18-4 INTR AQUAT F1 TR-528 PB 2006-102382

Fish project 1 (1,2,3-Trichloropropane) 96-18-4 INTR AQUAT F2 TR-528 PB 2006-102382

Fluometuron 2164-17-2 HERB/SYN FEED R2 M3 TR-195 PB80-217904 N N E E

Formamide 75-12-7 SOLV/SYN GAV R2 M3 TR-541 PB2009-115393 NE NE CE CE

Fumonisin B1 116355-83-0 FEED/NATL FEED R2 MV TR-496 PB2002-103492 CE NE NE NE

Furan 110-00-9 DTRG/N/S GAV R2 M3 TR-402 PB93-228419 CE CE CE CE

Furfural 98-01-1 INTR/N/S GAV R2 M3 TR-382 PB91-108662 SE NE CE CE

Furfuryl alcohol 98-00-0 FOOD/N/S INHAL R2 M3 TR-482 PB99-151482 SE EE SE SE

Furosemide 54-31-9 PHAR/SYN FEED R2 M3 TR-356 PB90-106162 EE NE NE NE

Gallium arsenide 1303-00-0 ELEC/SYN INHAL R2 M3 TR-492 PB2001-102003 NE CE NE NE

Geranyl acetate 105-87-3 FOOD/NATL GAV R2 M3 TR-252 PB88-174313 N N N N

Ginkgo biloba extract 90045-36-6 DIET/NATL GAV R2 M3 TR-578 PB2013-107073 SE SE CE CE

Ginseng 50647-08-0 DIET/NATL GAV R2 M3 TR-567 PB2012100177 NE NE NE NE

Glutaraldehyde 111-30-8 ADHS/SYN INHAL R2 M3 TR-490 PB2000-1014184 NE NE NE NE

Glycidamide 5694-00-8 LABC/SYN WATER RC MV TR-588 PB2015-102754 CE CE CE CE

Glycidol 556-52-5 SOLV/SYN GAV R2 M3 TR-374 PB90-259094 CE CE CE CE

Goldenseal root powder GOLDENSEALRT DIET/NATL FEED R2 M3 TR-562 PB2011-101388 CE CE SE SE

Guar gum 9000-30-0 FOOD/NATL FEED R2 M3 TR-229 PB82-202813 N N N N

Gum Arabic 9000-01-5 FOOD/NATL FEED R2 M3 TR-227 PB82-229584 N N N N

HC Blue 1 2784-94-3 DYE/SYN FEED R2 M3 TR-271 PB86-114683 EE SE CE CE

HC Blue 2 33229-34-4 DYE/SYN FEED R2 M3 TR-293 PB86-108339 NE NE NE NE

HC Red 3 2871-01-4 DYE/SYN GAV R2 M3 TR-281 PB86-188075 NE NE EE EE

HC Yellow 4 59820-43-8 DYE/SYN FEED R2 M3 TR-419 PB93-123883 EE NE NE NE

Heptachlor 76-44-8 PEST/SYN FEED R1 M3 TR-009 PB271967 N E P P

Hexachlorocyclopentadiene 77-47-4 FLAM/SYN INHAL R2 M3 TR-437 PB94-214186 NE NE NE NE

1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin 57653-85-7 PEST GAV R1 M3 TR-198 PB81-124844 E P P P

1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin 57653-85-7 PEST SP M6 TR-202 PB81-124836 N N

Hexachloroethane 67-72-1 SOLV/SYN GAV R1 M3 TR-068 PB282668 N N P P

Hexachloroethane 67-72-1 SOLV/SYN GAV R2 TR-361 PB90-170895 CE NE

Hexachlorophene 70-30-4 GERM/SYN FEED R2 TR-040 PB279525 N N

2,4-Hexadienal 142-83-6 FOOD/N/S GAV R2 M3 TR-509 PB2004102548 CE CE CE CE

Hexamethyl-p-rosaniline chloride 548-62-9 PHAR/SYN FEED R2 NR-338

Hexamethyl-p-rosaniline chloride 548-62-9 PHAR/SYN FEED M3 NR-304

4-Hexylresorcinol 136-77-6 PHAR/SYN GAV R2 M3 TR-330 PB89-128607 NE NE EE EE

Hydrazobenzene 122-66-7 REAG/SYN FEED R2 M3 TR-092 PB285791 P P N N

Hydrochlorothiazide 58-93-5 PHAR/SYN FEED R2 M3 TR-357 PB90-110156 NE NE EE EE

Hydroquinone 123-31-9 COSM/N/S GAV R2 M3 TR-366 PB90-240839 SE SE NE NE

5-(Hydroxymethyl)-2-furfural 67-47-0 NATL/N/S GAV R2 M3 TR-554 PB2010-113179 NE NE NE NE

8-Hydroxyquinoline 148-24-3 GERM/N/S FEED R2 M3 TR-276 PB85-213361 NE NE NE NE

ICRF-159 21416-87-5 CMOT IP/IJ R8 M3 TR-078 PB285853 N P N N

IPD (3,3'-iminobis-1-propanol

dimethanesulfonate (ester) hydrochloride)

3458-22-8 CMOT IP/IJ R8 M3 TR-018 PB277455 E E E E

Indium phosphide 22398-80-7 ELEC/SYN INHAL R2 M3 TR-499 PB2002-100069 CE CE CE CE

Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

INIT/PROM LABC/SYN SP M3 TR-441 PB96-214655

Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

INIT/PROM LABC/SYN SP M5 TR-441 PB96-214655

Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

INIT/PROM LABC/SYN SP M3 M5 M7 TR-441 PB96-214655

Interferon AD (AIDS Initiative) INTERFERONAD PHAR/NATL SC/IJ M3 TR-469 PB99-145807

Interferon AD + 3'-azido-3'-deoxythymidine

(AIDS Initiative)

INTAZTCOMB PHAR/SYN SC&GV M3 TR-469 PB99-145807

Interferon A (AIDS Initiative) 76543-88-9 PHAR/SYN SC/IJ M3 TR-469 PB99-145807

Iodinated glycerol 5634-39-9 PHAR/SYN GAV R2 M3 TR-340 PB90-259102 SE NE NE NE

Iodoform 75-47-8 PHAR/SYN GAV R1 M3 TR-110 PB286344 N N N N

Isobutene 115-11-7 RUBR/SYN INHAL R2 M3 TR-487 PB99-147670 SE NE NE NE

Isobutyl nitrite 542-56-3 ENVH/SYN INHAL R2 M3 TR-448 PB97-120232 CE CE SE SE

Isobutyraldehyde 78-84-2 INTR/N/S INHAL R2 M3 TR-472 PB99-134785 NE NE NE NE

Isoeugenol 97-54-1 FOOD/NATL GAV R2 M3 TR-551 PB2012111404 EE NE CE CE

Isophorone 78-59-1 INTR/SYN GAV R2 M3 TR-291 PB86-181823 SE NE EE EE

Isophosphamide 3778-73-2 CMOT/SYN IP/IJ R8 M3 TR-032 PB275677 N P N N

Isoprene 78-79-5 RUBR/N/S INHAL R2 TR-486 PB2000-101651 CE SE

Kava kava extract 9000-38-8 COSM GAV R2 M3 TR-571 PB2012-107445 EE NE CE CE

Lasiocarpine 303-34-4 PHAR/NATL FEED R2 TR-039 PB278641 P P

Lauric acid diethanolamine condensate 120-40-1 DTRG/SYN SP R2 M3 TR-480 PB99-169989 NE NE NE NE

Lead dimethyldithiocarbamate 19010-66-3 OCCH FEED R2 M3 TR-151 PB298512 N N N N

Leucomalachite green 129-73-7 FUNG/SYN FEED R2 MV TR-527 PB2005-107573 EE EE

*+ MR = Male Rat, FR = Female Rat, MM = Male Mice, FM = Female Mice.

See Page 4 for explanation of Carcnogen Codes
Last Update: 09/18/2015 10:46 Management Status Report Page 44

Ref No. 16

Printed Long-Term and Short-Term Study Reports

Long-Term Studies

CARCINOGEN

CODES

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No. NTIS **

NUMBER

MR FR MM FM*+

D-Limonene 5989-27-5 FOOD/NATL GAV R2 M3 TR-347 PB90-231416 CE NE NE NE

Lindane 58-89-9 PEST/SYN FEED R1 M3 TR-014 PB273480 N N N N

Lithocholic acid 434-13-9 LABC/NATL GAV R2 M3 TR-175 PB288476 N N N N

Locust bean gum 9000-40-2 FOOD/NATL FEED R2 M3 TR-221 PB82-163320 N N N N

Magnetic fields (EMF) ELECTROMAG ELEC WB R2 M3 TR-488 PB99-152886 EE NE NE NE

Malachite green 569-64-2 GERM/SYN FEED R2 MV TR-527 PB2005-107573 EE

Malaoxon 1634-78-2 PEST/SYN FEED R2 M3 TR-135 PB299858 N N N N

Malathion 121-75-5 PEST/SYN FEED R1 M3 TR-024 PB278527 N N N N

Malathion 121-75-5 PEST/SYN FEED R2 TR-192 PB300301 N N

Malonaldehyde, sodium salt 24382-04-5 FOOD/NATL GAV R2 M3 TR-331 PB89-204010 CE CE NE NE

Manganese sulfate monohydrate 10034-96-5 DYE/NATL FEED R2 M3 TR-428 PB94-217148 NE NE EE EE

D-Mannitol 69-65-8 PHAR/N/S FEED R2 M3 TR-236 PB83-129080 N N N N

Melamine 108-78-1 INTR/SYN FEED R2 M3 TR-245 PB83-202630 P N N N

DL-menthol 15356-70-4 PHAR/NATL FEED R2 M3 TR-098 PB288761 N N N N

2-Mercaptobenzothiazole 149-30-4 RUBR/SYN GAV R2 M3 TR-332 PB88-245154 SE SE NE NE

Mercuric chloride 7487-94-7 WOOD/SYN GAV R2 M3 TR-408 PB94-101649 SE EE EE EE

Methacrylonitrile 126-98-7 INTR/SYN GAV R2 M3 TR-497 PB2002-102199 NE NE NE NE

Methoxychlor 72-43-5 PEST/SYN FEED R1 M3 TR-035 PB278271 N N N N

8-Methoxypsoralen 298-81-7 PHAR/NATL GAV R2 TR-359 PB90-110164 CE NE

alpha-Methylbenzyl alcohol 98-85-1 COSM/SYN GAV R2 M3 TR-369 PB90-241092 SE NE NE NE

Methyl bromide 74-83-9 FUME/SYN INHAL M3 TR-385 PB92-189257 NE NE

Methyl carbamate 598-55-0 INTR/SYN GAV R2 M3 TR-328 PB88-168570 CE CE NE NE

Methyldopa sesquihydrate 41372-08-1 PHAR/SYN FEED R2 M3 TR-348 PB89-216527 NE NE EE EE

4,4'-Methylenebis(N,N-dimethyl)benzenamine 101-61-1 DYE/SYN FEED R2 M3 TR-186 PB299856 P P E E

Methylene blue trihydrate 7220-79-3 DYE GAV R2 M3 TR-540 PB2015-102751 SE NE SE SE

Methylene chloride 75-09-2 SOLV/SYN INHAL R2 M3 TR-306 PB86-187903 SE CE CE CE

4,4'-Methylenedianiline dihydrochloride 13552-44-8 INTR WATER R2 M3 TR-248 PB83-238824 P P P P

Methyleugenol 93-15-2 FOOD/NATL GAV R2 M3 TR-491 PB2000-107865 CE CE CE CE

2-Methylimidazole 693-98-1 INTR/N/S FEED R2 M3 TR-516 PB2005-103484 SE CE SE SE

4-Methylimidazole 822-36-6 FOOD/N/S FEED R2 M3 TR-535 PB2007-106091 NE EE CE CE

Methyl isobutyl ketone 108-10-1 PNT/SYN INHAL R2 M3 TR-538 PB2007-107706 SE EE SE SE

Methyl methacrylate 80-62-6 INTR/N/S INHAL R2 M3 TR-314 PB87-146742 NE NE NE NE

2-Methyl-1-nitroanthraquinone 129-15-7 INTR/SYN FEED R2 M3 TR-029 PB277439 P P P P

N-Methylolacrylamide 924-42-5 PLAS/SYN GAV R2 M3 TR-352 PB90-226374 NE NE CE CE

Methyl parathion 298-00-0 PEST/SYN FEED R2 M3 TR-157 PB295891 N N N N

Methylphenidate hydrochloride 298-59-9 PHAR/SYN FEED R2 M3 TR-439 PB96-162615 NE NE SE SE

alpha-Methylstyrene 98-83-9 ADHS INHAL R2 M3 TR-543 PB2014-104052 SE NE EE EE

Methyl trans-styryl ketone 1896-62-4 COSM/SYN SP R2 M3 TR-572 PB2012112090 NE NE NE NE

Mexacarbate 315-18-4 PEST/SYN FEED R1 M3 TR-147 PB287471 N N N N

Michler's ketone 90-94-8 DYE/SYN FEED R2 M3 TR-181 PB299855 P P P P

Milk thistle extract 84604-20-6 DIET/NATL FEED R2 M3 TR-565 PB2011-110858 NE NE NE NE

Mirex 2385-85-5 FLAM/SYN FEED R2 TR-313 PB90-241084 CE CE

Molybdenum trioxide 1313-27-5 DYE/SYN INHAL R2 M3 TR-462 PB98-107048 EE NE SE SE

Monochloroacetic acid 79-11-8 DYE/SYN GAV R2 M3 TR-396 PB92-189372 NE NE NE NE

Monuron 150-68-5 HERB/SYN FEED R2 M3 TR-266 PB89-109615 CE NE NE NE

beta-Myrcene 123-35-3 COSM/N/S GAV R2 M3 TR-557 PB2011-105235 CE EE CE CE

Nalidixic acid 389-08-2 PHAR/SYN FEED R2 M3 TR-368 PB90-256389 CE CE EE EE

Naphthalene 91-20-3 INTR/NATL INHAL M3 TR-410 PB92-224260/AS NE NE

Naphthalene 91-20-3 INTR/NATL INHAL R2 TR-500 PB2001-103699 CE CE

1,5-Naphthalenediamine 2243-62-1 INTR FEED R2 M3 TR-143 PB287646 N P P P

N-(1-Naphthyl)ethylenediamine

dihydrochloride

1465-25-4 REAG FEED R2 M3 TR-168 PB289733 N N N N

Navy fuels JP-5 8008-20-6 FUEL/N/S SP M3 TR-310 PB87-131678 NE NE

Nickel (II) oxide 1313-99-1 ELEC/N/S INHAL R2 M3 TR-451 PB97-116701 SE SE NE NE

Nickel sulfate hexahydrate 10101-97-0 ADHS/N/S INHAL R2 M3 TR-454 PB97-120216 NE NE NE NE

Nickel subsulfide 12035-72-2 ENVH/N/S INHAL R2 M3 TR-453 PB97-116784 CE CE NE NE

Nithiazide 139-94-6 PHAR/SYN FEED R2 M3 TR-146 PB295897 N P P P

Nitrilotriacetic acid (NTA) 139-13-9 TEXL/SYN FEED R2 M3 TR-006 PB266177 P P P P

Nitrilotriacetic acid trisodium monohydrate 18662-53-8 DTRG FEED R2 TR-006 PB266177 P P

Nitrilotriacetic acid trisodium monohydrate 18662-53-8 DTRG FEED R2 M3 TR-006 PB266177 E E N N

5-Nitroacenaphthene 602-87-9 DYE FEED R2 M3 TR-118 PB287347 P P N N

3-Nitro-p-acetophenetide 1777-84-0 PHAR FEED R2 M3 TR-133 PB299857 N N P P

p-Nitroaniline 100-01-6 DYE/SYN GAV M3 TR-418 PB94-104528 EE EE

5-Nitro-o-anisidine 99-59-2 INTR FEED R2 M3 TR-127 PB287411 P P E E

o-Nitroanisole 91-23-6 DYE/SYN FEED R2 M3 TR-416 PB94-109758 CE CE CE CE

4-Nitroanthranilic acid 619-17-0 INTR FEED R2 M3 TR-109 PB286942 N N N N

6-Nitrobenzimidazole 94-52-0 INTR FEED R2 M3 TR-117 PB293834 N N P P

p-Nitrobenzoic acid 62-23-7 DYE FEED R2 M3 TR-442 PB95-226254 NE SE NE NE

Nitrofen 1836-75-5 HERB/SYN FEED R2 M3 TR-184 PB296038 N N P P

Nitrofen 1836-75-5 HERB/SYN FEED R1 M3 TR-026 PB277440 IS P P P

Nitrofurantoin 67-20-9 PHAR/SYN FEED R2 M3 TR-341 PB90-197930 SE NE NE NE

*+ MR = Male Rat, FR = Female Rat, MM = Male Mice, FM = Female Mice.

See Page 4 for explanation of Carcnogen Codes
Last Update: 09/18/2015 10:46 Management Status Report Page 45

Ref No. 16

Printed Long-Term and Short-Term Study Reports

Long-Term Studies

CARCINOGEN

CODES

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No. NTIS **

NUMBER

MR FR MM FM*+

Nitrofurazone 59-87-0 PHAR/SYN FEED R2 M3 TR-337 PB89-102388 EE CE NE NE

Nitromethane 75-52-5 FUEL/SYN INHAL R2 M3 TR-461 PB97-205967 NE CE CE CE

1-Nitronaphthalene 86-57-7 DYE/SYN FEED R2 M3 TR-064 PB282310 N N N N

p-Nitrophenol 100-02-7 PEST/SYN SP M6 TR-417 PB94-109667 NE NE

2-Nitro-p-phenylenediamine 5307-14-2 DYE FEED R2 M3 TR-169 PB290304 N N N N

4-Nitro-o-phenylenediamine 99-56-9 REAG/SYN FEED R2 M3 TR-180 PB290306 N N N N

3-Nitropropionic acid 504-88-1 FOOD/NATL GAV R2 M3 TR-052 PB281102 E N N N

N-Nitrosodiphenylamine 86-30-6 FLAM FEED R2 M3 TR-164 PB298275 P P N N

p-Nitrosodiphenylamine 156-10-5 RUBR/SYN FEED R2 M3 TR-190 PB291500 P N P P

beta-Nitrostyrene 102-96-5 FUNG GAV R2 M3 TR-170 PB300949 N N N N

o-Nitrotoluene 88-72-2 RUBR/SYN FEED R2 M3 TR-504 PB2002-108715 CE CE CE CE

p-Nitrotoluene 99-99-0 DYE/SYN FEED R2 M3 TR-498 PB2002-108714 EE SE EE EE

5-Nitro-o-toluidine 99-55-8 DYE FEED R2 M3 TR-107 PB285872 N N P P

Ochratoxin A 303-47-9 COMT/NATL GAV R2 TR-358 PB90-219478 CE CE

Oleic acid diethanolamine condensate 93-83-4 COSM/SYN SP R2 M3 TR-481 PB99-167561 NE NE NE NE

Oxazepam 604-75-1 PHAR/SYN FEED M3 M6 TR-443 PB94-184181 CE CE

Oxazepam 604-75-1 PHAR/SYN FEED R2 TR-468 PB99-120875 EE NE

4,4'-Oxydianiline 101-80-4 ADHS/SYN FEED R2 M3 TR-205 PB80-217938 P P P P

Oxymetholone 434-07-1 PHAR/SYN GAV R2 M3 TR-485 PB2000-101419 EE CE

Oxytetracycline hydrochloride 2058-46-0 FEED/SYN FEED R2 M3 TR-315 PB87-204103 EE EE NE NE

Ozone 10028-15-6 WATR/NATL INHAL R2 M3 TR-440 PB95-226999 NE NE EE EE

Ozone 10028-15-6 WATR/NATL INHAL R2 M3 TR-440 PB95-226999 NE NE EE EE

Ozone/NNK OZONNNKCOMB NATL/NATL INHAL R2 TR-440 PB95-226999

Parathion 56-38-2 PEST/SYN FEED R1 M3 TR-070 PB288803 E E N N

Penicillin VK 132-98-9 PHAR/N/S GAV R2 M3 TR-336 PB89-128615 NE NE NE NE

Pentachloroanisole 1825-21-4 PEST GAV R2 M3 TR-414 PB94-104536 SE EE SE SE

Pentachloroethane 76-01-7 SOLV/SYN GAV R2 M3 TR-232 PB83-206748 E N P P

Pentachloronitrobenzene 82-68-8 PEST/SYN FEED R1 M3 TR-061 PB281732 N N N N

Pentachloronitrobenzene 82-68-8 PEST/SYN FEED M3 TR-325 PB87-208633 NE NE

Pentachlorophenol, Dowicide EC-7 87-86-5 WOOD/SYN FEED M3 TR-349 PB89-216536 CE CE

Pentachlorophenol, purified 87-86-5 PEST/SYN FEED R2 TR-483 PB99-152878 SE NE

Pentachlorophenol, technical 87-86-5 WOOD/SYN FEED M3 TR-349 PB89-216536 CE CE

Pentaerythritol tetranitrate 78-11-5 PHAR/SYN FEED R2 M3 TR-365 PB90-219452 EE EE NE NE

Phenazopyridine hydrochloride 136-40-3 PHAR/SYN FEED R2 M3 TR-099 PB286207 P P N N

Phenesterin 3546-10-9 CMOT/SYN GAV R8 M3 TR-060 PB283361 N P P P

Phenformin hydrochloride 834-28-6 PHAR/SYN FEED R2 M3 TR-007 PB266176 N N N N

Phenol 108-95-2 GERM/N/S WATER R2 M3 TR-203 PB80-217946 N N N N

Phenolphthalein 77-09-8 PHAR/SYN FEED R2 M3 TR-465 PB97-169882 CE SE CE CE

Phenoxybenzamine hydrochloride 63-92-3 PHAR/SYN IP/IJ R8 M3 TR-072 PB285095 P P P P

Phenylbutazone 50-33-9 PHAR/SYN GAV R2 M3 TR-367 PB90-258765 EE SE SE SE

p-Phenylenediamine dihydrochloride 624-18-0 DYE FEED R2 M3 TR-174 PB290124 N N N N

Phenylephrine hydrochloride 61-76-7 PHAR/SYN FEED R2 M3 TR-322 PB87-208609 NE NE NE NE

1-Phenyl-3-methyl-5-pyrazolone 89-25-8 DYE FEED R2 M3 TR-141 PB287122 N N N N

N-Phenyl-2-naphthylamine 135-88-6 RUBR/SYN FEED R2 M3 TR-333 PB88-216270 NE NE NE NE

o-Phenylphenol 90-43-7 FUNG/N/S SP M4 TR-301 PB86-217239 NE NE

N-Phenyl-p-phenylenediamine 101-54-2 COSM FEED R2 M3 TR-082 PB285856 N N N N

1-Phenyl-2-thiourea 103-85-5 REAG/SYN FEED R2 M3 TR-148 PB287357 N N N N

Phosphamidon 13171-21-6 PEST/SYN FEED R1 M3 TR-016 PB288800 E E N N

Photodieldrin 13366-73-9 PEST FEED R1 M3 TR-017 PB274393 N N N N

Phthalamide 88-96-0 PNT/SYN FEED R2 M3 TR-161 PB293831 N N N N

Phthalic anhydride 85-44-9 INTR/SYN FEED R2 M3 TR-159 PB293594 N N N N

Picloram 1918-02-1 HERB/SYN FEED R1 M3 TR-023 PB276471 N E N N

beta-Picoline 108-99-6 SYN WATER R2 M3 TR-580 PB2015-102752 NE SE EE EE

Piperonyl butoxide 51-03-6 PEST/N/S FEED R2 M3 TR-120 PB288753 N N N N

Piperonyl sulfoxide 120-62-7 N/S/N/S FEED R2 M3 TR-124 PB288778 N N P P

Pivalolactone 1955-45-9 INTR/SYN GAV R2 M3 TR-140 PB287645 P P N N

Polybrominated biphenyl mixture (Firemaster

FF-1)

67774-32-7 FLAM GAV R2 M3 TR-244 PB83-240473 P P P P

Polybrominated biphenyl mixture (Firemaster

FF-1)

67774-32-7 FLAM FEED R2 M3 TR-398 PB94-184066 CE CE CE CE

Polysorbate 80 (glycol) 9005-65-6 COSM/SYN FEED R2 M3 TR-415 PB92-189331/AS EE NE NE NE

Polyvinyl alcohol 9002-89-5 PHAR/SYN IVAG M3 TR-474 PB98-148869

Primidone (primaclone) 125-33-7 PHAR/SYN FEED R2 M3 TR-476 PB2001-102004 EE NE CE CE

Probenecid 57-66-9 PHAR/SYN GAV R2 M3 TR-395 PB92-129584/AS NE NE NE NE

Procarbazine hydrochloride 366-70-1 CMOT/SYN IP/IJ R8 M3 TR-019 PB299902 P P P P

Proflavin hydrochloride 952-23-8 PHAR/SYN FEED R2 M3 TR-005 PB268553 E N E E

Promethazine hydrochloride 58-33-3 PHAR/SYN GAV R2 M3 TR-425 PB94-210192 NE NE NE NE

Propargyl alcohol 107-19-7 HERB/SYN INHAL R2 M3 TR-552 PB2009-102214 SE NE SE SE

Propylene 115-07-1 INTR/NATL INHAL R2 M3 TR-272 PB86-145521 NE NE NE NE

Propylene glycol mono-t-butyl ether 57018-52-7 SOLV/SYN INHAL RB R2 M3 TR-515 PB2004-104949 EE NE CE CE

1,2-Propylene oxide 75-56-9 FUME/SYN INHAL R2 M3 TR-267 PB85-179653 SE SE CE CE

*+ MR = Male Rat, FR = Female Rat, MM = Male Mice, FM = Female Mice.

See Page 4 for explanation of Carcnogen Codes
Last Update: 09/18/2015 10:46 Management Status Report Page 46

Ref No. 16

Printed Long-Term and Short-Term Study Reports

Long-Term Studies

CARCINOGEN

CODES

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No. NTIS **

NUMBER

MR FR MM FM*+

Propyl gallate 121-79-9 COSM/SYN FEED R2 M3 TR-240 PB83-180042 E N E E

Pulegone 89-82-7 DIET/N/S GAV R2 M3 TR-563 PB2011-114186 NE SE CE CE

Pyrazinamide 98-96-4 PHAR/SYN FEED R2 M3 TR-048 PB280251 N N N N

Pyridine 110-86-1 SOLV/SYN WATER R9 R2 M3 TR-470 PB2000-106687 SE EE CE CE

Pyridine 110-86-1 SOLV/SYN WATER R9 TR-470 PB2000-106687 EE

Pyrilamine 91-84-9 PHAR/SYN FEED R2 M3 NR-408/409

Pyrimethamine 58-14-0 PHAR/SYN FEED R2 M3 TR-077 PB282608 N N IS IS

Pyrogallol 87-66-1 N/S SP R2 M3 TR-574 PB2013-105507 NE NE EE EE

Quercetin 117-39-5 PHAR/NATL FEED R2 TR-409 PB93-147478 SE NE

Reserpine 50-55-5 PHAR/NATL FEED R2 M3 TR-193 PB83-165761 P N P P

Resorcinol 108-46-3 PHAR/SYN GAV R2 M3 TR-403 PB93-126381 NE NE NE NE

All-trans-retinyl palmitate 79-81-2 COSM/SYN SP MT TR-568 PB2013-100226

Rhodamine 6G 989-38-8 DYE/N/S FEED R2 M3 TR-364 PB90-219460 EE EE NE NE

Riddelliine 23246-96-0 PHAR/NATL GAV R2 M3 TR-508 PB2003-106432 CE CE CE CE

Rotenone 83-79-4 PEST/NATL FEED R2 M3 TR-320 PB89-139760 EE NE NE NE

Roxarsone 121-19-7 REAG/SYN FEED R2 M3 TR-345 PB89-216543 EE NE NE NE

Safflower oil 8001-23-8 DIET/NATL GAV R2 TR-426 PB95-103958

Salicylazosulfapyridine 599-79-1 PHAR/SYN GAV R2 M3 TR-457 PB97-212708 SE SE CE CE

Scopolamine hydrobromide trihydrate 6533-68-2 PHAR/SYN GAV R2 M3 TR-445 PB97-208946 NE NE NE NE

Selenium sulfide 7446-34-6 COSM/NATL GAV R2 M3 TR-194 PB82-164955 P P N N

Selenium sulfide 7446-34-6 COSM/NATL SP M4 TR-197 PB82-165291 N N

Selsun EMTDP-74 COSM/N/S SP M4 TR-199 PB82-164542 N N

Sodium azide 26628-22-8 FUME/SYN GAV R2 TR-389 PB92-135615 NE NE

Sodium dichromate dihydrate (VI) 7789-12-0 ENVH/SYN WATER R2 M3 TR-546 PB2008-114134 CE CE CE CE

Sodium diethyldithiocarbamate 148-18-5 INTR/SYN FEED R2 M3 TR-172 PB293833 N N N N

Sodium Fluoride 7681-49-4 ADHS/N/S WATER R2 M3 TR-393 PB91-178137 EE NE NE NE

Sodium nitrite 7632-00-0 INTR/SYN WATER R2 M3 TR-495 PB2001-107676 NE NE NE NE

Sodium xylenesulfonate 1300-72-7 DTRG/SYN SP R2 M3 TR-464 PB98-168719 NE NE NE NE

Stannous chloride 7772-99-8 DYE/SYN FEED R2 M3 TR-231 PB82-242553 E N N N

Stoddard solvent (type lIC) 64742-88-7 ADHS/SYN INHAL R2 M3 TR-519 PB2005-103487 SE NE NE NE

Styrene 100-42-5 RUBR/SYN GAV R2 M3 TR-185 PB300977 N N E E

Styrene-acrylonitrile trimer SANTRIMER2 PLAS FEED R2 TR-573 PB2012112739 NE NE

Succinic anhydride 108-30-5 FOOD/SYN GAV R2 M3 TR-373 PB90-231135 NE NE NE NE

Sulfallate 95-06-7 HERB/SYN FEED R1 M3 TR-115 PB286386 P P P P

Sulfamethazine 57-68-1 PHAR/SYN FEED R2 NR-420

Sulfamethazine 57-68-1 PHAR/SYN FEED M3 NR-418

Sulfisoxazole 127-69-5 PHAR/SYN GAV R2 M3 TR-138 PB288779 N N N N

3-Sulfolene 77-79-2 SOLV/SYN GAV R1 M3 TR-102 PB284656 N N N N

4,4'-Sulfonyldianiline (Dapsone) 80-08-0 PHAR/SYN FEED R2 M3 TR-020 PB274394 P N N N

Talc 14807-96-6 COSM/NATL INHAL R2 M3 TR-421 PB94-215985 SE CE NE NE

Tara gum 39300-88-4 FOOD/NATL FEED R2 M3 TR-224 PB82-195546 N N N N

Toxic equivalency factor evaluation (Binary

mixture; PCB 126/PCB 153)

TEFBINARYMIX ELEC/SYN GAV HSD TR-530 PB2008109743 CE

Toxic equivalency factor evaluation (PECDF

(Pentachlorodibenzofuran))

57117-31-4 ELEC/N/S GAV HSD TR-525 PB2007-103746 SE

Toxic equivalency factor evaluation (PCB

118)

31508-00-6 COMT/SYN GAV HSD TR-559 PB2011-103866 CE

Toxic equivalency factor evaluation (PCB

Mixture; PCB 126/PCB 118)

TEFPCBMIX ELEC/SYN GAV HSD TR-531 PB2007-103748 CE

Toxic equivalency factor evaluation (TCDD) 1746-01-6 LABC/SYN GAV HSD TR-521 PB 2006-112291 CE

Tetrabromobisphenol A 79-94-7 FLAM GAV RE RD M3 TR-587 PB2015-102753 EE CE SE SE

3,3',4,4'-Tetrachloroazobenzene 14047-09-7 PEST/SYN GAV M3 HSD TR-558 PB2011-104500 CE CE CE CE

2,3,7,8-Tetrachlorodibenzo-p-dioxin 1746-01-6 PEST/SYN GAV R1 M3 TR-209 PB82-163445 P P P P

2,3,7,8-Tetrachlorodibenzo-p-dioxin 1746-01-6 PEST/SYN SP M6 TR-201 PB82-163684 E E

Tetrachlorodiphenylethane 72-54-8 PEST/SYN FEED R1 M3 TR-131 PB286367 E N N N

1,1,1,2-Tetrachloroethane 630-20-6 INTR GAV R2 M3 TR-237 PB83-218206 E N P P

1,1,2,2-Tetrachloroethane 79-34-5 SOLV/SYN GAV R1 M3 TR-027 PB277453 E N P P

Tetrachloroethylene 127-18-4 FUME/SYN GAV R1 M3 TR-013 PB272940 IS IS P P

Tetrachloroethylene 127-18-4 FUME/SYN INHAL R2 M3 TR-311 PB87-147054 CE SE CE CE

2,3,5,6-Tetrachloro-4-nitroanisole 2438-88-2 PEST FEED R2 M3 TR-114 PB287642 N N N N

Tetrachlorvinphos 961-11-5 PEST FEED R1 M3 TR-033 PB278650 N P P P

Tetracycline hydrochloride 64-75-5 PHAR/NATL FEED R2 M3 TR-344 PB90-198540 NE NE NE NE

Tetraethylthiuram disulfide 97-77-8 PEST/SYN FEED R2 M3 TR-166 PB298514 N N N N

Tetrafluoroethylene 116-14-3 FOOD/SYN INHAL R2 M3 TR-450 PB97-208508 CE CE CE CE

1-trans-delta-9-Tetrahydrocannabinol 1972-08-3 PHAR/NATL GAV R2 M3 TR-446 PB97-182208 NE NE EE EE

Tetrahydrofuran 109-99-9 FDPK/SYN INHAL R2 M3 TR-475 PB98-164544 SE NE NE NE

Tetrakis(hydroxymethyl)phosphonium chloride 124-64-1 FLAM/SYN GAV R2 M3 TR-296 PB87-204137 NE NE NE NE

Tetrakis(hydroxymethyl)phosphonium sulfate 55566-30-8 FLAM/SYN GAV R2 M3 TR-296 PB87-204137 NE NE NE NE

Tetralin 119-64-2 SOLV/SYN INHAL R2 RB M3 TR-561 PB2011-110773 SE SE NE NE

Tetranitromethane 509-14-8 FUEL/SYN INHAL R2 M3 TR-386 PB91-113373 CE CE CE CE

Theophylline 58-55-9 PHAR/NATL GAV R2 M3 TR-473 PB99-113342 NE NE NE NE

*+ MR = Male Rat, FR = Female Rat, MM = Male Mice, FM = Female Mice.

See Page 4 for explanation of Carcnogen Codes
Last Update: 09/18/2015 10:46 Management Status Report Page 47

Ref No. 16

Printed Long-Term and Short-Term Study Reports

Long-Term Studies

CARCINOGEN

CODES

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No. NTIS **

NUMBER

MR FR MM FM*+

4,4-Thiobis(6-tert-butyl-m-cresol) 96-69-5 FDPK/SYN FEED R2 M3 TR-435 PB95-225751 NE NE NE NE

4,4'-Thiodianiline 139-65-1 DYE/SYN FEED R2 M3 TR-047 PB280360 P P P P

beta-Thioguanidine deoxyriboside 789-61-7 CMOT/NATL IP/IJ R8 M3 TR-057 PB281540 E P IS IS

alpha/beta Thujone mixture 76231-76-0 COSM/NATL GAV R2 M3 TR-570 PB2012-102007 SE NE NE NE

Titanium dioxide 13463-67-7 PHAR/N/S FEED R2 M3 TR-097 PB288780 N N N N

Titanocene dichloride 1271-19-8 INTR/SYN GAV R2 M3 TR-399 PB92-129576/AS EE EE

Tolazamide 1156-19-0 PHAR/SYN FEED R2 M3 TR-051 PB284610 N N N N

Tolbutamide 64-77-7 PHAR/SYN FEED R2 M3 TR-031 PB274483 N N N N

Toluene 108-88-3 FUEL/N/S INHAL R2 M3 TR-371 PB90-256371 NE NE NE NE

2,6-Toluenediamine dihydrochloride

(2,6-diaminotoluene dihydrochloride)

15481-70-6 INTR/SYN FEED R2 M3 TR-200 PB80-217912 N N N N

2,5-Toluenediamine sulfate 6369-59-1 COSM FEED R2 M3 TR-126 PB287127 N N N N

2,4- & 2,6-Toluene diisocyanate 26471-62-5 PLAS GAV R2 M3 TR-251 PB87-115176 P P N N

o-Toluidine hydrochloride 636-21-5 DYE FEED R2 M3 TR-153 PB290908 P P P P

Toxaphene 8001-35-2 PEST/SYN FEED R1 M3 TR-037 PB292290 E E P P

Toxic equivalency factor evaluation (Dioxin

mixture)

TEFDIOXINMIX ELEC/SYN GAV HSD TR-526 PB2007-103747 CE

Toxic equivalency factor evaluation (PCB

153- 2,2'-4,4',5,5'-hexachlorobiphenyl)

35065-27-1 ELEC/SYN GAV HSD TR-529 PB 2006-113416 EE

Toxic equivalency factor evaluation ((PCB

126) 3,3',4,4',5-pentachlorobiphenyl)

57465-28-8 ELEC/SYN GAV HSD TR-520 PB 2006-109013 CE

Tremolite 14567-73-8 GLAS/NATL FEED R2 TR-277 PB90-226572 N N

Triamterene 396-01-0 PHAR/SYN FEED R2 M3 TR-420 PB94-213782 EE NE SE SE

Tribromomethane 75-25-2 INTR/SYN GAV R2 M3 TR-350 PB90-110149 SE CE NE NE

Tricaprylin 538-23-8 FOOD/NATL GAV R2 TR-426 PB95-103958

1,1,1-Trichloroethane 71-55-6 SOLV/SYN GAV R1 M3 TR-003 PB265082 IS IS IS IS

1,1,2-Trichloroethane 79-00-5 SOLV/SYN GAV R1 M3 TR-074 PB283337 N N P P

Trichloroethylene 79-01-6 ADHS/SYN GAV R1 M3 TR-002 PB264122 N N P P

Trichloroethylene 79-01-6 ADHS/SYN GAV R3 R4 TR-273 PB88-218896 IS IS

Trichloroethylene 79-01-6 ADHS/SYN GAV R1 R6 TR-273 PB88-218896 IS IS

Trichloroethylene 79-01-6 ADHS/SYN GAV R2 M3 TR-243 PB91-111815 IS N P P

Trichlorofluoromethane 75-69-4 SOLV/SYN GAV R1 M3 TR-106 PB286187 IS IS N N

2,4,6-Trichlorophenol 88-06-2 HERB/SYN FEED R2 M3 TR-155 PB293770 P N P P

1,2,3-Trichloropropane 96-18-4 PNT/SYN GAV R2 M3 TR-384 PB94-207784 CE CE CE CE

Tricresyl Phosphate 1330-78-5 FLAM/SYN FEED R2 M3 TR-433 PB95-227377 NE NE NE NE

Triethanolamine 102-71-6 COSM/SYN SP R2 M3 M7 TR-449 PB2000-102846 EE NE IS IS

Triethanolamine 102-71-6 COSM/SYN SP M3 TR-518 PB2004-106613 EE EE

Trifluralin 1582-09-8 HERB/SYN FEED R1 M3 TR-034 PB278610 N N N N

2,4,5-Trimethylaniline 137-17-7 DYE FEED R2 M3 TR-160 PB293802 P P E E

Trimethylolpropane triacrylate 15625-89-5 ADHS SP R2 M3 TR-576 PB2013-103565 EE NE NE NE

Trimethylphosphate 512-56-1 FUEL GAV R2 M3 TR-081 PB285851 P N N N

Trimethylthiourea 2489-77-2 ADHS FEED R2 M3 TR-129 PB288802 N P N N

Triphenyltin hydroxide 76-87-9 PEST/SYN FEED R2 M3 TR-139 PB287399 N N N N

Triprolidine 486-12-4 PHAR/SYN FEED R2 M3 NR-414/415

tris(Aziridinyl)-phosphine sulfide

(Thio-TEPA)

52-24-4 CMOT/SYN IP/IJ R8 M3 TR-058 PB285702 P P P P

Tris(2-Chloroethyl) Phosphate 115-96-8 FLAM/SYN GAV R2 M3 TR-391 PB92-105147 CE CE EE EE

tris(2,3-Dibromopropyl) phosphate 126-72-7 FLAM/SYN FEED R2 M3 TR-076 PB280271 P P P P

tris(2-Ethylhexyl)phosphate 78-42-2 FLAM GAV R2 M3 TR-274 PB85-171502 EE NE NE NE

Trisodium ethylenediaminetetraacetate

trihydrate (EDTA)

150-38-9 FOOD/SYN FEED R2 M3 TR-011 PB270938 N N N N

L-Tryptophan 73-22-3 DIET/NATL FEED R2 M3 TR-071 PB285792 N N N N

Turmeric, oleoresin (curcumin) 8024-37-1 FOOD/NATL FEED R2 M3 TR-427 PB94-184173 NE EE EE EE

Urethane 51-79-6 PNT/SYN WATER MV TR-510 PB2005-103486 CE CE

Urethane + ethanol (combination) URETHCOMB PNT/N/S WATER MV TR-510 PB2005-103486 CE CE

Vanadium pentoxide 1314-62-1 INTR/NATL INHAL R2 M3 TR-507 PB2003102385 SE EE CE CE

4-Vinylcyclohexene 100-40-3 INTR GAV R2 M3 TR-303 PB87-116182 IS IS IS IS

4-Vinyl-1-cyclohexene diepoxide 106-87-6 INTR SP R2 M3 TR-362 PB90-219957 CE CE CE CE

Vinylidene Chloride 75-35-4 INTR/SYN INHAL R2 M3 TR-582 CE SE CE CE

Vinylidene Chloride 75-35-4 INTR/SYN GAV R2 M3 TR-228 PB82-258393 N N N N

Vinyl toluene 25013-15-4 SOLV/SYN INHAL R2 M3 TR-375 PB90-260035 NE NE NE NE

Water disinfection byproducts

(Bromochloroacetic acid)

5589-96-8 WATR/SYN WATER R2 M3 TR-549 PB2010-100853 CE CE CE CE

Water disinfection byproducts

(Bromodichloromethane)

75-27-4 FLAM/SYN WATER R2 M3 TR-532 PB 2006-111415 NE

Water disinfection byproducts

(Dibromoacetic acid)

631-64-1 WATR/SYN WATER R2 M3 TR-537 PB2008-109733 SE SE CE CE

Water disinfection byproducts

(Dibromoacetonitrile)

3252-43-5 INTR WATER R2 M3 TR-544 PB2010-114243 CE SE CE CE

Water disinfection byproducts (Sodium

chlorate)

7775-09-9 WATR/SYN WATER R2 M3 TR-517 PB 2006-107479 SE SE NE NE

*+ MR = Male Rat, FR = Female Rat, MM = Male Mice, FM = Female Mice.

See Page 4 for explanation of Carcnogen Codes
Last Update: 09/18/2015 10:46 Management Status Report Page 48

Ref No. 16

Printed Long-Term and Short-Term Study Reports

Long-Term Studies

CARCINOGEN

CODES

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES RPT No. NTIS **

NUMBER

MR FR MM FM*+

Xylenes (mixed) 1330-20-7 FUEL/SYN GAV R2 M3 TR-327 PB87-189684 NE NE NE NE

2,6-Xylidine 87-62-7 DYE/SYN FEED RA TR-278 PB90-256363 P P

Zearalenone 17924-92-4 PHAR/NATL FEED R2 M3 TR-235 PB83-165753 N N P P

Ziram 137-30-4 RUBR/SYN FEED R2 M3 TR-238 PB83-202622 P N N N

*+ MR = Male Rat, FR = Female Rat, MM = Male Mice, FM = Female Mice.

See Page 4 for explanation of Carcnogen Codes

Ref No. 17

Long-Term Exposure Studies for Which Technical Reports Were Not Prepared

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES COMMENTS FOOTNOTE

REFERENCE

Actinomycin D 50-76-0 CMOT/NATL IP/IJ R8 M4 RESULTS REPORTED IN

JOURNAL ARTICLE

A

Agaritine 2757-90-6 CMOT/NATL WATER M4 E

3-Amino-9-ethylcarbazole 132-32-1 DYE FEED R2 M3

Amsacrine 51264-14-3 CMOT/SYN IP/IJ R2 M3

L-Arginine Glutamate 4320-30-3 NATL FEED R2 M1

Azathioprine 446-86-6 PHAR/SYN IP/IJ R8 M4 RESULTS REPORTED IN

JOURNAL ARTICLE

A

Benzyl chloride 100-44-7 INTR/SYN GAV R2 M3 H

1,3-bis(Chloroethyl)-1-nitrosourea 154-93-8 CMOT IP/IJ R8 M4 RESULTS REPORTED IN

JOURNAL ARTICLE

A

bis(Chloromethyl) ether 542-88-1 INTR INHAL R8 H1

1,3-Butadiene 106-99-0 INTR/N/S INHAL M3 Q

Calcium chromate 13765-19-0 INTR/SYN INHAL R8 H1

Carbon tetrachloride 56-23-5 INTR/SYN GAV R1 M3

Chlorambucil 305-03-3 CMOT/SYN IP/IJ R8 M4 A

Chloromethyl methyl ether 107-30-2 INTR/SYN INHAL R8 H1

Chromium 7440-47-3 INTR/NATL INHAL R8 H1

Cyclohexanone 108-94-1 SOLV/SYN WATER R2 M3 RESULTS REPORTED IN

JOURNAL ARTICLE

J

Cyclophosphamide 50-18-0 CMOT/SYN IP/IJ R8 M4 A

Cytarabine 147-94-4 PHAR/SYN IP/IJ R8 M4 RESULTS REPORTED IN

JOURNAL ARTICLE

A

Cytoxal alcohol 4465-94-5 CMOT IP/IJ R8 M4 RESULTS REPORTED IN

JOURNAL ARTICLE

A

Dacarbazine 4342-03-4 CMOT/SYN IP/IJ R8 M4 RESULTS REPORTED IN

JOURNAL ARTICLE

A

Daunomycin 20830-81-3 CMOT/NATL IP/IJ R8 M4 RESULTS REPORTED IN

JOURNAL ARTICLE

A

o,p'-DDD 53-19-0 PEST/SYN IP/IJ R8 M4 A

Dibromodulcitol 10318-26-0 CMOT/SYN IP/IJ R8 M4 RESULTS REPORTED IN

JOURNAL ARTICLE

A

Dibromomannitol 488-41-5 CMOT/SYN IP/IJ R8 M4 RESULTS REPORTED IN

JOURNAL ARTICLE

A

Dichloromethotrexate 528-74-5 CMOT IP/IJ R8 M4 RESULTS REPORTED IN

JOURNAL ARTICLE

A

Dimethylcarbamoyl chloride 79-44-7 INTR INHAL R8 H1

Dimethyl hydrazine (DMH) 57-14-7 FUEL/SYN INHAL M1

1,2-Dimethylhydrazine 2HCl 306-37-6 FUEL FEED R2

Epichlorhydrin 106-89-8 INTR/SYN INHAL R8

Guanazole 1455-77-2 CMOT IP/IJ R8 M4 RESULTS REPORTED IN

JOURNAL ARTICLE

A

Hexanamide 628-02-4 INTR FEED R2 M1

Hydroxyurea 127-07-1 CMOT/SYN IP/IJ R8 M4 A

Lomustine 13010-47-4 CMOT/SYN IP/IJ R8 M4 A

Melphalan 148-82-3 CMOT/SYN IP/IJ R8 M4 A

6-Mercaptopurine 50-44-2 CMOT/SYN IP/IJ R8 M4 A

Merphalan 531-76-0 CMOT IP/IJ R8 M4 A

Methapyrilene hydrochloride 135-23-9 PHAR/SYN FEED R2 M3 RESULTS REPORTED IN

JOURNAL ARTICLE

F

Methotrexate 59-05-2 CMOT/SYN IP/IJ R8 M4 RESULTS REPORTED IN

JOURNAL ARTICLE

A

Methyl CCNU 13909-09-6 CMOT IP/IJ R8 M4 A

Methyl isocyanate 624-83-9 INTR/SYN INHAL NA R

6-Methylmercaptopurine ribonucleoside 342-69-8 CMOT IP/IJ R8 M4 RESULTS REPORTED IN

JOURNAL ARTICLE

A

2-Methyl-1-nitroanthraquinone 129-15-7 INTR/SYN FEED M3 RESULTS REPORTED IN

JOURNAL ARTICLE

D

Mitomycin C 50-07-7 CMOT/N/S IP/IJ R8 M4 A

Mouse ageing study MOUSEAGE M3 RESULTS REPORTED IN

JOURNAL ARTICLE

O
Last Update: 09/18/2015 10:46 Management Status Report Page 49

Ref No. 17

Long-Term Exposure Studies for Which Technical Reports Were Not Prepared

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES COMMENTS FOOTNOTE

REFERENCE

Nitrofurazone 59-87-0 PHAR/SYN FEED M3

N-Nitrosodiethanolamine 1116-54-7 COMT/SYN WATER R2 NA L

NTP 90 diet study DIET90 FEED/SYN FEED M3 NA N

NTP 91/92 diet study DIET9192 FEED/SYN FEED R2 N

Polyurethane 9009-54-5 RUBR INHAL R8 H1

Prednisone 53-03-2 CMOT/N/S IP/IJ R8 M4 A

Procarbazine hydrochloride 366-70-1 CMOT/SYN IP/IJ R8 M4 A

Rotenone 83-79-4 PEST/NATL IP/IJ R2 RESULTS REPORTED IN

NCTR REPORT

M

Sodium Fluoride 7681-49-4 ADHS/N/S WATER R2 Supplemental study P

Streptozotocin 18883-66-4 CMOT/NATL IP/IJ R8 M4 A

Styrene oxide 96-09-3 INTR GAV R2 M3 RESULTS REPORTED IN

JOURNAL ARTICLE

K

p-Tolylurea 622-51-5 LABC FEED R2 M1

Uracil mustard 66-75-1 CMOT/SYN IP/IJ R8 M4 RESULTS REPORTED IN

JOURNAL ARTICLE

A

Vinblastine 865-21-4 CMOT/NATL IP/IJ R8 M4 RESULTS REPORTED IN

JOURNAL ARTICLE

A

Vincristine 57-22-7 CMOT/NATL IP/IJ R8 M4 A

Wollastonite calcium silicates 13983-17-0 PNT/NATL INHAL R2 RESULTS REPORTED IN

JOURNAL ARTICLE

I

With the exception of those documents available only through the National Technical Information Service* the following

papers are available upon request from the Central Data Management (CDM) (TELEPHONE: 919-541-3419; FAX: (301)

480-3210; Mail Drop K2-05, NIEHS, P. O. BOX 12233, Research Triangle Park, NC USA 27709; EMAIL: CDM@NIEHS.NIH.GOV) .

A EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949

(1977)

D ASK Murthy, JR Baker, ER Smith, GG Wade, Development of Hemangiosarcomas in B6C3F1 Mice Fed

2-Methyl-1-Nitroanthraquinone. Int. J. Cancer 19:117-121 (1977)

E B Toth, CR Raha, L Wallcave, D Nagel, Attempted Tumor Induction with Agaritine in Mice. Anticancer Res 1:255-258

(1981)

F W Lijinsky, MD Reuber, BN Blackwell, Liver Tumors Induced in Rats by Oral Administration of the Antihistaminic

Methapyrilene Hydrochloride. Science 209:817-819 (1980)

H W Lijinsky, Chronic Bioassay of Benzyl Chloride in F344 Rats and (C57BL/6JXBALB/C)F1 Mice. J Natl Cancer Inst.

1986 Jun;76(6):1231-6.

I McConnell EE, Hall L, Adkins B Jr., Studies on the Chronic Toxicity (Inhalation) of Wollastonite in Fischer 344

Rats. Inhalation Toxicology 3:323-337 (1991).

J Lijinsky W, RM Kovatch, Chronic Toxicity Study of Cyclohexanone in Rats and Mice. J Natl Cancer Inst. 1986

Oct;77(4):941-9.

K W Lijinsky. Rat and Mouse Forestomach Tumors Induced by Chronic Oral Administration of Styrene Oxide. J Natl

Cancer Inst. 1986 Aug;77(2):471-6.

L W Lijinsky, RM Kovatch, Induction of Liver Tumors in Rats by Nitrosodiethanolamine at Low Doses. Carcinogenesis

6, No. 12:1679-1681 (1985)

M Tumorogenic Potential of Rotenone and its Specificity for Mammary Tissue, published by National Center for

ToxicologicalResearch (NCTR Experiment No. 216). Call NCTR (501-543-7115) for availability of document.

N GN Rao, J Edmondson and MR Elwell. Influence of dietary fat and fiber on growth and tumor incidences in Fischer

344 rats (presented in an abstract at the 33rd annual meeting of the Society of Toxicology in March 1994).

Toxicologist 14(1):303, 1994.

O GN Rao. Growth, Body Weight Patterns, and life Span of the B6C3F1 Mouse. Pathology of the Mouse (R. Maronpot,

Ed.) Cache River Press, Vienna, IL. (1999)

P Supplemental 2-Year Sodium Fluoride Male Rat Study (available on NTP website http://ntp.niehs.nih.gov/go/16389)

Q Bucher JR, Melnick RL, and Hildebrandt PK. Lack of Carcinogenicity in Mice Exposed Once to High Concentrations of

1,3-Butadiene. J. Nat. Cancer Inst 85: 1866-1867 (1993).

R Bucher JR, Uraih LC, Hildebrandt PK, Sauer RM and Seely JC. Carcinogenicity and Pulmonary Pathology Associated

with a Single 2-Hour Inhalation Exposure of Laboratory Rodents to Methyl Isocyanate. J. Nat. Cancer Inst

81:1586-1587 (1989).

* National Technical Information Service, Department of Commerce, 5285 Port Royal Road, Springfield, Virginia 22161,

Phone: 1-800-553-6847 or (703)487-4650.

Appendix

Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES

Abrasive blasting agents (coal slag) COALSLAG IND/NATL INHAL RD

Abrasive blasting agents (crushed glass) CRUSHEDGLASS IND/NATL INHAL RD

Abrasive blasting agents (garnet) GARNET IND/NATL INHAL RD

Acetaminophen (4-hydroxyacetanilide) 103-90-2 PHAR/SYN GAV R2

Acetochlor 34256-82-1 HERB/SYN GAV HSD

Acetonitrile 75-05-8 SOLV/SYN INHAL R2 M3
Last Update: 09/18/2015 10:46 Management Status Report Page 50

Appendix

Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES

Acrylamide 79-06-1 COMT/SYN FEED RC MV

Adeno-associated viral vector (hEPO) AAVIRVECEPO N/A/N/S ID/CN MW

Adenoviral vector (hGH) ADNVIRVECHGH N/A/N/S ID/CN R2

Adenoviral Vector (AdhAQP1) ADNVIRVECAQP ID/CN R2

Allyl bromide 106-95-6 COSM/SYN SP MI

Ametryn 834-12-8 HERB GAV HSD

9-Aminoacridine hydrochloride 134-50-9 PHAR/SYN SP R2 M3

9-Aminoacridine hydrochloride 134-50-9 PHAR/SYN FEED R2 M3

2-(4-Aminophenyl)-6-methyl-7-benzothiazole

sulfonic acid

130-17-6 INTR FEED R2 M3

3-Aminopyridine 462-08-8 DYE/SYN GAV RD M3

2-Aminopyridine 504-29-0 INTR/SYN GAV RD M3

4-Aminopyridine 504-24-5 INTR/SYN GAV RD M3

Comparison study of Aminopyridines/Troponin

levels

AMINOPYRCOMP DYE/N/A GAV RD M3

Androstenedione 63-05-8 DIET/SYN GAV R2 M3

Androstenedione 63-05-8 DIET/SYN SP R2 M3

Arsenic antioxidant mixture ANTIOXCOMBO2 WATER ME

Arsenic antioxidant mixture ANTIOXCOMBO2 WATER MN

Antioxidant model (TRAMP) -

N-acetylcysteine

616-91-1 PHAR/SYN GAV MU M1

Antioxidant model (TRAMP) -

Epigallocatechin gallate

989-51-5 PHAR/SYN GAV MU M1

Antioxidant model (TRAMP) - NAO (spinach

extract)

NAOSPINEXTR PHAR/NATL GAV M1 MU

Arsine 7784-42-1 ELEC/SYN INHAL H1 NA

3'-Azido-3'-deoxythymidine and

2',3'-Dideoxycytidine

AZTDDCCOMB CMOT/SYN GAV M3

3'-Azido-3'-deoxythymidine and

2',3'-Dideoxyinosine (AIDS initiative)

AZTDDICOMB PHAR/SYN GAV M3

Azodicarbonamide 123-77-3 RUBR/SYN INHAL R2 M3

AZT + Methadone HCl (AIDS) AZTMETHCOMB PHAR/SYN GAV M3

AZT + Nitazoxanide (AIDS Initiative) AZT+NITAZOX PHAR/SYN GAV M3

AZT + TMP/SMX (mixture) combination AZTTMPSMX PHAR GAV M3

AZT + TMP/SMX (mixture) combination AZTTMPSMX PHAR GAV M3

Benzidine dihydrochloride 531-85-1 DYE WATER R2

Benzonitrile 100-47-0 INTR/N/S GAV R2 M3

Benzyl acetate + glycine combination study GLYCINEBENZA FEED R2

Benzyltrimethyl ammonium chloride 56-93-9 DYE SP R2 M3

2,2-bis(Bromomethyl)-1,3-propanediol 3296-90-0 FLAM/SYN GAV R2 M3

Bisphenol A 80-05-7 INTR/SYN GAV HSD

Black Cohosh 84776-26-1 DIET/NATL GAV M3

Black Cohosh 84776-26-1 DIET/NATL GAV M3

Black Cohosh 84776-26-1 DIET/NATL GAV RE

Bromobenzene 108-86-1 INTR/SYN INHAL R2 M3

Bromobenzene 108-86-1 INTR/SYN GAV R2 M3

1,3-Butadiene 106-99-0 INTR/N/S INHAL R2

n-Butyl Glycidyl Ether 2426-08-6 INTR/SYN INHAL RD M3

tert-Butyl hydroperoxide 75-91-2 INTR/SYN SP R2 M3

tert-Butyl hydroperoxide 75-91-2 INTR/SYN GAV R2 M3

tert-Butylphenyl Diphenyl Phosphate 56803-37-3 GAV HSD

Butyraldehyde 123-72-8 FOOD/NATL GAV R2 M3

Caffeine 58-08-2 PHAR/NATL WATER R2 M3

DL-Camphor 76-22-2 PLAS/N/S SP R2 M3

Carbaryl 63-25-2 PEST/SYN GAV HSD

Carbon disulfide 75-15-0 SOLV/SYN INHAL NA

Carbon disulfide 75-15-0 SOLV/SYN INHAL R2

Carbon disulfide 75-15-0 SOLV/SYN INHAL M1

Cardio Transmitter Gene Evaluation CARDIOGENEVL PHAR N/A M2

Carisoprodol 78-44-4 PHAR/SYN GAV R2 M3

Chitosan 9012-76-4 DIET/NATL FEED R8

Chloramphenicol sodium succinate 982-57-0 PHAR/N/S FEED R2 M3

3-Chloro-4-(dichloromethyl)-5-hydroxy2(5H)-furanone(MX)77439-76-0 COMT WATER M3

bis(2-Chloroethoxy)methane 111-91-1 SOLV/SYN GAV M3

bis(2-Chloroethoxy)methane 111-91-1 SOLV/SYN GAV MZ 63

M15

4-Chloro-2-nitroaniline 89-63-4 DYE/SYN GAV R2 M3

Chloroprene 126-99-8 PLAS/SYN INHAL MD

Chloroprene 126-99-8 PLAS/SYN INHAL ME MI ML

1-Chloro-2-propanol, technical 127-00-4 INTR/SYN INHAL R2 M3

o-Chloropyridine 109-09-1 COSM/SYN SP R2 M3

p-Chloro-a,a,a-trifluorotoluene 98-56-6 SYN INHAL M3 HSD

C.I. Phthalocyanine green 1328-53-6 DYE FEED R2 M3

C.I. Direct Blue 6 2602-46-2 COSM WATER R2

1,8-Cineol 470-82-6 PHAR/NATL MICRO R2 M3
Last Update: 09/18/2015 10:46 Management Status Report Page 51

Appendix

Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES

1,8-Cineol 470-82-6 PHAR/NATL GAV R2 M3

Cinnamaldehyde 104-55-2 FOOD/N/S FEED R2 M3

trans-Cinnamaldehyde 14371-10-9 FOOD/NATL GAV R2

Citral 5392-40-5 FOOD/NATL GAV R2 M3

Citral 5392-40-5 FOOD/NATL MICRO R2 M3

p-Cresidine 120-71-8 DYE FEED MA M8 M9

Crotonaldehyde 4170-30-3 INTR/SYN GAV R2 M3

Cumene hydroperoxide 80-15-9 INTR/SYN SP R2 M3

Cyclanilide 113136-77-9 FERT GAV HSD

2-Cyclohexen-1-one 930-68-7 INTR/SYN INHAL R2 M3

Cyclohexene oxide 286-20-4 IND/SYN SP R2 M3

Cyclohexene oxide 286-20-4 IND/SYN GAV R2 M3

Cyclohexene oxide 286-20-4 IND/SYN GAV R2 M3

Cyfluthrin 68359-37-5 PEST GAV HSD

Cyprodinil 121552-61-2 FUNG GAV HSD

2,4-Decadienal 25152-84-5 FOOD/N/S GAV R2 M3

1,2-Dibromo-2,4-dicyanobutane 35691-65-7 FUNG/SYN GAV R2 M3

1,2-Dibromo-2,4-dicyanobutane 35691-65-7 FUNG/SYN SP R2 M3

5,6-Dichloro-2-benzothiazolamine 24072-75-1 INTR FEED R2 M3

cis & trans 1,2-Dichloroethylene 540-59-0 SOLV/SYN MICRO R2 M3

cis-1,2-Dichloroethylene 156-59-2 SOLV MICRO R2 M3

trans-1,2-Dichloroethylene 156-60-5 SOLV MICRO R2 M3

trans-1,2-Dichloroethylene 156-60-5 SOLV GAV R2 M3

2,3-Dichloropropylene 78-88-6 PEST/SYN INHAL R2 M3

2',3'-Dideoxycytidine 7481-89-2 PHAR/SYN GAV R2 M3

2',3'-Dideoxycytidine 7481-89-2 PHAR/SYN GAV M3

2',3'-Dideoxycytidine 7481-89-2 PHAR/SYN GAV M3 MB

Diet Evaluation Study DIETEVAL FEED/N/A FEED MY

Di(2-ethylhexyl) Phthalate 117-81-7 PLAS/SYN GAV HSD

Di(2-ethylhexyl) Phthalate 117-81-7 PLAS/SYN IVOR RH

1,2-Dihydro-2,2,4-trimethylquinoline

(polymer)

26780-96-1 RUBR SP R2 M3

Dimethylaminopropyl chloride, hydrochloride 5407-04-5 INTR/SYN GAV R2 M3

N,N-Dimethyl-p-toluidine 99-97-8 INTR/SYN GAV HSD

Divinylbenzene 1321-74-0 PLAS INHAL

Ephedrine + caffeine combination EPHEDCOMBO PHAR/NATL GAV M3

Ephedrine + caffeine combination EPHEDCOMBO PHAR/NATL GAV MZ M15

63

Estragole 140-67-0 FOOD/NATL GAV HSD

Ethoxyquin 91-53-2 FOOD/SYN FEED R2 M3

2-Ethylhexyl Diphenyl Phosphate 1241-94-7 GAV HSD

Ethyl vinyl ketone 1629-58-9 INTR/N/S INHAL R2 M3

Ferrocene 102-54-5 FUEL/SYN INHAL R2 M3

Flusilazole 85509-19-9 FUNG/SYN GAV HSD

Flutamide 13311-84-7 CMOT/SYN GAV HSD

Formaldehyde 50-00-0 FUNG/NATL INHAL M3

Formaldehyde 50-00-0 FUNG/NATL INHAL M1 C3B6

B6129

Gallium oxide 12024-21-4 METL/NATL INHAL R2 M3

Glucosamine 3416-24-8 DIET/NATL GAV ZO ZL

Glucosamine Hydrochloride + Chondroitin

Sulfate

GLUCOSCHONDN DIET GAV ZL ZO

Glyoxal 107-22-2 PAPR/SYN WATER R2 M3

Gum Guggul Extract GUMGUGGULEXT DIET/NATL GAV M3 HSD

Indoxacarb 173584-44-6 FUME GAV HSD

Insertional mutagenesis (Radiation Levels) INSERTMUTRAD LABC/N/A WB MG

Insertional mutagenesis II (SIN vector) INSERTMUT2 LABC IV MG

Insertional mutagenesis (LTR/SIN vectors) INSERTMUT LABC IV MG

Interferon AD + ddC (AIDS Initiative) INTDDCCOMB PHAR/SYN SC/IJ M3

Ionic liquid Toxicity IONICLIQUIDS SYN WATER M3 HSD

Isodecyl Diphenyl Phosphate 29761-21-5 PLAS GAV HSD

Isopropylated Phenol Phosphate 68937-41-7 FLAM/SYN GAV HSD

Lead(2+) acetate 301-04-2 PHAR/SYN FEED R2

Lead contaminated soil PBCONTAMSOIL COMT/NATL FEED R2

Lead ores LEADORES METL/NATL FEED R2

Lead oxide 1317-36-8 INTR/N/S FEED R2

Lead sulfide 1314-87-0 PNT/NATL FEED R2

Lead sulfide 1314-87-0 PNT/NATL FEED R2

Lipopolysaccharides from Escherichia coli ECOLI_LPS COMT/NATL IP/IJ HSD

Magnetic fields (EMF) ELECTROMAG ELEC WB MD MC

Melamine + Cyanuric Acid combination MELCYANCOMB ADHS/SYN GAV RC

Melatonin 73-31-4 DIET/N/S GAV R5 R2

Melatonin 73-31-4 DIET/N/S GAV R2 R5

2-Mercaptobenzimidazole 583-39-1 ELEC/SYN INHAL R2 M3

2-Mercaptobenzimidazole 583-39-1 ELEC/SYN INHAL R2 M3

Metal working fluids (Syntilo 1023) SYNTILO1023 METL/SYN INHAL RE M3
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Appendix

Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES

Metal working fluids (Trim SC210) TRIMSC210 METL/SYN INHAL RD M3

Methapyrilene hydrochloride 135-23-9 PHAR/SYN FEED R2 M3

Methdilazine 1982-37-2 PHAR/SYN GAV R2 M3

6-Methoxy-2-benzothiazolamine 1747-60-0 INTR FEED R2 M3

2-Methoxy-4-nitroaniline 97-52-9 SYN FEED M3 HSD

4-(6-Methyl-2-benzothiazolyl)-benzenamine 92-36-4 INTR FEED R2 M3

Methyl coumarin 92-48-8 FOOD/NATL GAV R2 M3

Methylene blue trihydrate 7220-79-3 DYE GAV R2 M3

Methylene blue trihydrate 7220-79-3 DYE GAV R2 M3

Methyleugenol (TGMX rat liver evaluation) 93-15-2 GAV RD

3-Methyl-6-methoxy-2-amino-benzothiazolium

chloride

EMTDP-76 INTR FEED R2 M3

3-Methyl-6-methoxy-2-amino-benzothiazolium

chloride

EMTDP-76 INTR GAV R2

alpha-Methylstyrene 98-83-9 ADHS INHAL R2 M3

Methyl trans-styryl ketone 1896-62-4 COSM/SYN SP R2 M3

Methyl trans-styryl ketone 1896-62-4 COSM/SYN FEED R2 M3

Methyl vinyl ketone 78-94-4 PHAR/SYN INHAL R2 M3

Microcystin-LA (TGMX) 96180-79-9 COMT/NATL IV RE

Microcystin-LR (TGMX) 101043-37-2 COMT/NATL IV RE

Microcystin mixture (TGMX) MICROCYSTNMX NATL/NATL IV RE

Myristicin 607-91-0 FOOD/NATL GAV RD M3

Nanoscale material (Quantum dots) QUANTUMDOTS NANO/SYN SP M0

Nanoscale material (Rutile titanium

dioxide)

1317-80-2 NANO/N/S SP ME

NCT/DERT standardization experiment (APAP &

AMAP)

NCTSTANDARD N/A GAV MZ

Nitrobenzene 98-95-3 SOLV/SYN SP R2 M3

m-Nitrobenzoic acid 121-92-6 INTR FEED R2 M3

5-(4-Nitrophenyl)-2,4-pentadien-1-al (NPPD) 2608-48-2 LABC SP R2 M3

5-(4-Nitrophenyl)-2,4-pentadien-1-al (NPPD) 2608-48-2 LABC FEED R2 M3

N-Nitrosodimethylamine (TGMX rat liver

evaluation)

62-75-9 WATER RD

p-Nitrotoluene 99-99-0 DYE/SYN GAV R2 M3

NTP-2000 diet DIET2000 FEED/SYN FEED R2

NTP-88 diet study (EGMBE) DIET88+EGMBE SOLV/SYN WATER R2 M3

NTP-88 diet study (EGMEE) DIET88+EGMEE SOLV/SYN WATER R2 M3

NTP-88 diet study (EGMME) DIET88+EGMME SOLV/SYN WATER R2 M3

NTP-88 diet study (m-Nitrotoluene) DIET88+MNITR DYE FEED R2 M3

NTP-88 diet study (o-Nitrotoluene) DIET88+ONITR DYE FEED R2 M3

NTP-88 diet study (p-Nitrotoluene) DIET88+PNITR DYE FEED R2 M3

Oxymetholone 434-07-1 PHAR/SYN FEED R2 M3

Perfluorooctanoic Acid 335-67-1 ELEC/SYN GAV HSD

Peroxisome project (Dibutyl phthalate) 84-74-2 PLAS/SYN FEED M3 H1

HSD

Peroxisome project

(2,4-Dichlorophenoxyacetic acid)

94-75-7 PEST/SYN FEED M3 H1

HSD

Peroxisome project (Gemfibrozil) 25812-30-0 PHAR/SYN FEED M3 H1

HSD

Phosphine 7803-51-2 PEST/NATL INHAL R2 M3

Pregnancy Rate Comparison Study PREGRATECOMP N/A N/A HSDD

HSDI

Prevention 1 (Melatonin) 73-31-4 DIET/NATL GAV MA

Prevention 2 (Melatonin) 73-31-4 PHAR/N/S FEED MA

Prevention 2 (Silymarin) 65666-07-1 PHAR/NATL FEED MA

Prevention 2 (Silymarin + melatonin) SILYMARN+MEL DIET/N/S FEED MA

Prevention 3 (Melatonin) 73-31-4 PHAR/N/S FEED MA

Prevention 6 (low isoflavone soy protein

powder)

ISOFLAVSOYPT FOOD/NATL FEED MA

Prevention 4 (Curcumin) 458-37-7 FOOD/NATL FEED MA

Prevention 7 (feed controls) PREVENTION7 FEED FEED MA

Prevention 1 (Flaxseed oil) 8001-26-1 DIET/NATL GAV MA

Prevention 1 (Flaxseed oil + melatonin) FLAXSEED+MEL DIET/N/S GAV MA

Prevention 4 (Indole-3-carbinol) 700-06-1 FOOD/N/S FEED MA

Prevention 6 (isoflavone concentrate) ISOFLAVCONCN NATL/NATL FEED MA

Prevention 4 (Melatonin) 73-31-4 PHAR/NATL FEED MA

Prevention 5 (Melatonin) 73-31-4 PHAR/N/S FEED MA

Prevention 4 (Melatonin + curcumin) MEL+CURCUMIN DYE/NATL FEED MA

Prevention 4 (Melatonin +

indole-3-carbinol)

MEL+INDOLCAR PHAR FEED MA

Prevention 10 (Soy isoflavone concentrate) PREVENTION10 NATL/NATL FEED MA

Propantheline bromide 50-34-0 PHAR/SYN FEED R2 M3

2,5-Pyridinedicarboxylic Acid, Dipropyl

Ester

136-45-8 HERB/SYN GAV HSD

QT drugs (bepridil hydrochloride) 74764-40-2 PHAR/SYN CAPS O3

QT drugs (diltiazem hydrochloride) 33286-22-5 PHAR/SYN CAPS O3
Last Update: 09/18/2015 10:46 Management Status Report Page 53

Appendix

Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES

QT drugs (Loratadine) 79794-75-5 PHAR/SYN CAPS O3

QT drugs (Lovastatin) 75330-75-5 PHAR/SYN CAPS O3

QT drugs (sotalol hydrochloride) 959-24-0 PHAR/SYN CAPS O3

QT drugs (terfenadine) 50679-08-8 PHAR/SYN CAPS O3

Rat feed study (TGMX rat liver evaluation) TGMXRALVFEED N/A FEED RD

Reserpine 50-55-5 PHAR/NATL FEED MA M8 M9

Retinoid project 2

(4-(Hydroxyphenyl)retinamide)

65646-68-6 PHAR/N/S FEED MA

Retinoid project 1 RETINOID1 PHAR/N/S FEED MA

Retinoid project 3 (Retinol acetate) 127-47-9 PHAR/N/S FEED MA

Retinoid project 4

(4-(Hydroxyphenyl)retinamide)

65646-68-6 PHAR/N/S FEED MA

Retinoid project 5

(4-(Hydroxyphenyl)retinamide)

65646-68-6 PHAR/N/S FEED MA

Retinoid project 6 (Arotinoid) 125533-88-2 PHAR/N/S FEED MA

Retinoid project 3 (Arotinoid) 125533-88-2 PHAR/N/S FEED MA

Retinoid project 5 (Arotinoid) 125533-88-2 CMOT FEED MA

Retinoid project 6 (4-HPR) 65646-68-6 PHAR/N/S FEED MA

Retroviral vectors RETROVIRVECT PHAR IP/IJ M3

Retroviral vectors RETROVIRVECT PHAR IP/IJ R2

Retroviral vectors RETROVIRVECT PHAR WB R2 M3 MD

Retroviral vectors RETROVIRVECT PHAR IV M3 MD

Scopolamine hydrobromide trihydrate 6533-68-2 PHAR/SYN WATER R2 M3

Silica, crystalline - quartz 14808-60-7 ELEC/NATL INHAL R2

Silica, crystalline - quartz 14808-60-7 ELEC/NATL INHAL R2

Silica, crystalline - quartz 14808-60-7 ELEC/NATL INHAL R2

Simazine 122-34-9 HERB/SYN GAV HSD

Styrene 100-42-5 RUBR/SYN INHAL R2 M3

Tebufenpyrad 119168-77-3 PEST GAV HSD

TEF transgenics (PCB 126) 57465-28-8 SP ME

TEF transgenics (PCB 126 / PECDF mixture) TEFTGMIXTURE SP ME

TEF transgenics (PECDF) 57117-31-4 SP ME

TEF transgenics (TCDD) 1746-01-6 SP ME

Tetrabromobisphenol A 79-94-7 FLAM GAV RE

2,2',4,4'-Tetrabromodiphenyl Ether (BDE-47) 5436-43-1 ENVH/SYN GAV MM MK

3,3',4,4'-Tetrachloroazobenzene 14047-09-7 PEST/SYN GAV R8

1,1,2,2-Tetrachloroethane 79-34-5 SOLV/SYN GAV R2 M3

Tetradecanoyl phorbol acetate (TPA) 16561-29-8 REAG/NATL SP ME

Tetrahydrofuran 109-99-9 FDPK/SYN GAV R2 M3

4,4-Thiobis(6-tert-butyl-m-cresol) 96-69-5 FDPK/SYN FEED R2 M3

Thiophene 110-02-1 PHAR/N/S INHAL R2 M3

D-alpha-Tocopheryl acetate 58-95-7 DIET/NATL GAV R8 R2

Toxicogenomics study of allylbenzene &

propenylbenzene class flavor constituents

(TGMX)

TGMXFLAVCLAS FOOD/N/S GAV RD

Transgenic LECM (1-Chloro-2-propanol,

technical)

127-00-4 INTR/SYN WATER MD

Transgenic LECM (1-Chloro-2-propanol,

technical)

127-00-4 INTR/SYN SP ME

Transgenic LECM (Coconut oil acid

diethanolamine condensate)

68603-42-9 TEXL/N/S SP ME

Transgenic LECM (Coconut oil acid

diethanolamine condensate)

68603-42-9 TEXL/N/S SP MD

Transgenic LECM (Furfuryl alcohol) 98-00-0 FOOD/N/S SP ME

Transgenic LECM (Lauric acid diethanolamine

condensate)

120-40-1 DTRG/SYN SP MD

Transgenic LECM (Lauric acid diethanolamine

condensate)

120-40-1 DTRG/SYN SP ME

Transgenic LECM (Oleic acid diethanolamine

condensate)

93-83-4 COSM/SYN SP MD

Transgenic LECM (Oleic acid diethanolamine

condensate)

93-83-4 COSM/SYN SP ME

Transgenic LECM (Pentachlorophenol) 87-86-5 PEST/SYN FEED MD

Transgenic LECM (Pentachlorophenol) 87-86-5 PEST/SYN SP ME

Transgenic LECM (Pyridine) 110-86-1 SOLV/SYN WATER MD

Transgenic LECM (Pyridine) 110-86-1 SOLV/SYN SP ME

Transgenic LECM (Tetradecanoyl phorbol

acetate (TPA))

16561-29-8 NATL/NATL SP MN

Transgenic LEP (p-Anisidine hydrochloride) 20265-97-8 INTR/SYN FEED MH MO

Transgenic LEP (Cyclosporin A) 59865-13-3 PHAR/NATL GAV MH MO

Transgenic LEP (Melphalan) 148-82-3 CMOT/SYN GAV MO MH

Transgenic LEP (p-Cresidine) 120-71-8 DYE FEED MH MO

Transgenic LEP (Resorcinol) 108-46-3 PHAR/SYN GAV MH MO

Transgenic LEP (Vinyl carbamate) 15805-73-9 INTR/SYN IP/IJ MH MO

Transgenic model evaluation (p-Anisidine

HCl)

20265-97-8 DYE SP ME
Last Update: 09/18/2015 10:46 Management Status Report Page 54

Appendix

Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES

Transgenic model evaluation

(Bromodichloromethane)

75-27-4 INTR/SYN GAV MP

Transgenic model evaluation

(Bromodichloromethane)

75-27-4 INTR/SYN WATER MP

Transgenic model evaluation

(Cyclophosphamide monohydrate)

6055-19-2 CMOT/SYN SP MI MN

Transgenic model evaluation

(Cyclophosphamide monohydrate)

6055-19-2 CMOT/SYN GAV MI MN

Transgenic model evaluation (Cyclosporin A) 59865-13-3 PHAR/N/S GAV ME

Transgenic model evaluation (Cyclosporin A) 59865-13-3 PHAR/N/S GAV MD

Transgenic model evaluation (DES) 56-53-1 PHAR/SYN SP ME

Transgenic model evaluation (DES) 56-53-1 PHAR/SYN SC/IJ MD

Transgenic model evaluation (DES) 56-53-1 PHAR/SYN SP MI MN

Transgenic model evaluation (DES) 56-53-1 PHAR/SYN GAV MN MI

Transgenic model evaluation

(2,4-Diaminotoluene)

95-80-7 DYE/SYN SP ME

Transgenic model evaluation

(2,4-Diaminotoluene)

95-80-7 DYE/SYN FEED MD

Transgenic model evaluation

(2,6-Diaminotoluene 2HCl)

15481-70-6 SYN SP ME

Transgenic model evaluation

(2,6-Diaminotoluene 2HCl)

15481-70-6 SYN FEED MD

Transgenic model evaluation

(Di(2-ethylhexyl) phthalate)

117-81-7 PLAS/SYN SP MN

Transgenic model evaluation

(Di(2-ethylhexyl) phthalate)

117-81-7 PLAS/SYN FEED MN

Transgenic model evaluation (Ethinyl

estradiol)

57-63-6 PHAR/N/S SP MI MN

Transgenic model evaluation (Ethinyl

estradiol)

57-63-6 PHAR/N/S GAV MN MI

Transgenic model evaluation

(8-Hydroxyquinoline)

148-24-3 GERM/N/S SP ME

Transgenic model evaluation

(8-Hydroxyquinoline)

148-24-3 GERM/N/S FEED MD

Transgenic model evaluation (Melphalan) 148-82-3 CMOT/SYN SP ME

Transgenic model evaluation (Melphalan) 148-82-3 CMOT/SYN IP/IJ MD

Transgenic model evaluation (Melphalan) 148-82-3 CMOT/SYN SP MN MI

Transgenic model evaluation (Melphalan) 148-82-3 CMOT/SYN GAV MI MN

Transgenic model evaluation (Melphalan) 148-82-3 CMOT/SYN GAV MI

Transgenic model evaluation

(N-Methylolacrylamide)

924-42-5 PLAS/SYN GAV ME

Transgenic model evaluation

(N-Methylolacrylamide)

924-42-5 PLAS/SYN SP ME

Transgenic model evaluation

(Methylphenidate hydrochloride)

298-59-9 PHAR/SYN FEED ME MD

Transgenic model evaluation

(Phenolphthalein)

77-09-8 PHAR/SYN FEED MD

Transgenic model evaluation (Resorcinol) 108-46-3 PHAR/SYN SP ME

Transgenic model evaluation (Resorcinol) 108-46-3 PHAR/SYN GAV MD

Transgenic model evaluation (Rotenone) 83-79-4 PEST/NATL SP ME

Transgenic model evaluation (Rotenone) 83-79-4 PEST/NATL FEED MD

Transgenic Model Evaluation

(2,3,7,8-Tetrachlorodibenzodioxin)

1746-01-6 COMT/SYN SP ME

Transgenic Model Evaluation

(2,3,7,8-Tetrachlorodibenzodioxin)

1746-01-6 COMT/SYN GAV MD

Transgenic Model Evaluation

(2,3,7,8-Tetrachlorodibenzodioxin)

1746-01-6 COMT/SYN GAV ME

Transgenic Model Evaluation

(2,3,7,8-Tetrachlorodibenzodioxin)

1746-01-6 COMT/SYN SP ME

Transgenic model evaluation (WY-14643) 50892-23-4 PHAR/SYN SP MN

Transgenic model evaluation (WY-14643) 50892-23-4 PHAR/SYN FEED MN

Transgenic LECM (diethanolamine) 111-42-2 TEXL/SYN SP MN

Triamterene 396-01-0 PHAR/SYN FEED R2 M3

Trichlorfon 52-68-6 PEST/SYN FEED R2 M3

Trichloroethylene 79-01-6 ADHS/SYN FEED R2

Trichloroethylene 79-01-6 ADHS/SYN GAV R2

1,2,3-Trichloropropane 96-18-4 PNT/SYN GAV R2 M3

Triclosan 3380-34-5 COSM/SYN GAV HSD

Tricresyl Phosphate 1330-78-5 FLAM/SYN GAV HSD

Tricresyl Phosphate 1330-78-5 FLAM/SYN GAV R2 M3

Triethanolamine 102-71-6 COSM/SYN WATER R2 M3

Triethanolamine 102-71-6 COSM/SYN SP R2 M3

Triethanolamine 102-71-6 COSM/SYN INHAL R2 M3

Trimellitic anhydride 552-30-7 INTR/SYN FEED R2 M3

Trimellitic anhydride 552-30-7 INTR/SYN GAV R2 M3

Tripelennamine hydrochloride 154-69-8 PHAR/SYN FEED R2 M3
Last Update: 09/18/2015 10:46 Management Status Report Page 55

Appendix

Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

CHEMICAL NAME PRIMARY CAS

NUMBER

USE ROUTE SPECIES

Vincamine 1617-90-9 DIET/NATL GAV M3 HSD

Vinclozolin 50471-44-8 FUNG/SYN GAV HSD

Vinylidene fluoride 75-38-7 SOLV/SYN INHAL R2 M3

Water disinfection byproducts

(Bromodichloroacetic Acid)

71133-14-7 ENVH/NATL WATER R2 M3

Water disinfection byproducts

(Bromodichloromethane)

75-27-4 FLAM/SYN WATER R2 M3

Water disinfection byproducts

(Bromodichloromethane)

75-27-4 FLAM/SYN GAV R2 M3

Water disinfection byproducts

(Dibromoacetic acid)

631-64-1 WATR/SYN WATER R2 M3

Water disinfection byproducts

(Dichloroacetic acid)

79-43-6 GERM/SYN WATER R2 M3

Welding fumes STEELWELDFUM METL

Wyeth 14,643 (WY) 50892-23-4 PHAR/SYN GAV HSD
Last Update: 09/18/2015 10:46 Management Status Report Page 56

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

50-00-0 Formaldehyde 51 *

50-00-0 Formaldehyde 51 *

50-06-6 Phenobarbital 32 5

50-07-7 Mitomycin C 48 17

50-18-0 Cyclophosphamide 48 17

50-29-3 Dichlorodiphenyltrichloroethane

(DDT)

41 16

50-33-9 Phenylbutazone 45 16

50-34-0 Propantheline bromide 52 *

50-44-2 6-Mercaptopurine 48 17

50-55-5 Reserpine 46 16

50-55-5 Reserpine 53 *

50-76-0 Actinomycin D 48 17

50-81-7 L-Ascorbic acid 39 16

51-03-6 Piperonyl butoxide 45 16

51-79-6 Urethane 37 16

51-79-6 Urethane 47 16

@ 51-79-6 Urethane + ethanol (combination)

(Primary CASRN is URETHCOMB)

37 16

@ 51-79-6 Urethane + ethanol (combination)

(Primary CASRN is URETHCOMB)

47 16

52-24-4 tris(Aziridinyl)-phosphine

sulfide (Thio-TEPA)

47 16

52-68-6 Trichlorfon 54 *

53-03-2 Prednisone 49 17

53-19-0 o,p'-DDD 48 17

54-31-9 Furosemide 43 16

@ 54-85-3 AZT + Isoniazid (AIDS Initiative)

(Primary CASRN is

AZTISONIAZID)

35 16

55-31-2 Epinephrine hydrochloride 42 16

55-38-9 Fenthion 42 16

56-23-5 Carbon tetrachloride 48 17

@ 56-23-5 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

56-38-2 Parathion 45 16

@ 56-40-6 Benzyl acetate + glycine

combination study

(Primary CASRN is

GLYCINEBENZA)

50 *

56-53-1 Transgenic model evaluation (DES) 54 *

56-53-1 Transgenic model evaluation (DES) 54 *

56-53-1 Transgenic model evaluation (DES) 54 *

56-53-1 Transgenic model evaluation (DES) 54 *

56-72-4 Coumaphos 41 16

56-93-9 Benzyltrimethyl ammonium chloride 35 16

56-93-9 Benzyltrimethyl ammonium chloride 50 *

56-93-9 Benzyltrimethyl ammonium chloride 35 16

57-06-7 Allyl isothiocyanate 39 16

@ 57-14-7 Asbestos, chrysotile(IR) +

Dimethyl hydrazine

(Primary CASRN is 12001-29-5)

39 16

@ 57-14-7 Asbestos, chrysotile(IR) +

Dimethyl hydrazine

(Primary CASRN is 12001-29-5)

39 16

57-14-7 Dimethyl hydrazine (DMH) 48 17

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

57-22-7 Vincristine 49 17

57-41-0 5,5-Diphenylhydantoin (phenytoin) 42 16

57-63-6 Endocrine disruptor (Ethinyl

estradiol)

42 16

57-63-6 Endocrine disruptor (Ethinyl

estradiol)

42 16

57-63-6 Endocrine disruptor (Ethinyl

estradiol)

42 16

57-63-6 Transgenic model evaluation

(Ethinyl estradiol)

54 *

57-63-6 Transgenic model evaluation

(Ethinyl estradiol)

54 *

57-66-9 Probenecid 45 16

57-68-1 Sulfamethazine 46 16

57-68-1 Sulfamethazine 46 16

57-74-9 Chlordane (analytical grade) 40 16

@ 57-97-6 Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

(Primary CASRN is INIT/PROM)

43 16

@ 57-97-6 Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

(Primary CASRN is INIT/PROM)

43 16

@ 57-97-6 Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

(Primary CASRN is INIT/PROM)

43 16

@ 57-97-6 Magnetic fields + DMBA initiation

promotion

(Primary CASRN is EMF+DMBA)

37 16

58-08-2 Caffeine 50 *

@ 58-08-2 Ephedrine + caffeine combination

(Primary CASRN is EPHEDCOMBO)

51 *

@ 58-08-2 Ephedrine + caffeine combination

(Primary CASRN is EPHEDCOMBO)

51 *

58-14-0 Pyrimethamine 46 16

58-33-3 Promethazine hydrochloride 38 16

58-33-3 Promethazine hydrochloride 45 16

58-55-9 Theophylline 38 16

58-55-9 Theophylline 38 16

58-55-9 Theophylline 46 16

58-89-9 Lindane 44 16

58-93-5 Hydrochlorothiazide 43 16

@ 58-95-7 Arsenic antioxidant mixture

(Primary CASRN is

ANTIOXCOMBO2)

50 *

@ 58-95-7 Arsenic antioxidant mixture

(Primary CASRN is

ANTIOXCOMBO2)

50 *

58-95-7 D-alpha-Tocopheryl acetate 53 *

59-05-2 Methotrexate 48 17

59-87-0 Nitrofurazone 45 16

59-87-0 Nitrofurazone 49 17

60-13-9 DL-amphetamine sulfate 39 16

60-51-5 Dimethoate 42 16

60-57-1 Dieldrin 42 16

60-57-1 Dieldrin 42 16

61-76-7 Phenylephrine hydrochloride 45 16

62-23-7 p-Nitrobenzoic acid 38 16

62-23-7 p-Nitrobenzoic acid 44 16

62-73-7 Dichlorvos 41 16
Last Update: 09/18/2015 10:46 Management Status Report Page 57

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

62-73-7 Dichlorvos 41 16

62-75-9 N-Nitrosodimethylamine (TGMX rat

liver evaluation)

52 *

63-05-8 Androstenedione 50 *

63-05-8 Androstenedione 50 *

63-05-8 Androstenedione 39 16

63-25-2 Carbaryl 50 *

63-92-3 Phenoxybenzamine hydrochloride 45 16

64-17-5 Ethanol 42 16

@ 64-17-5 Urethane + ethanol (combination)

(Primary CASRN is URETHCOMB)

37 16

@ 64-17-5 Urethane + ethanol (combination)

(Primary CASRN is URETHCOMB)

47 16

64-18-6 Formic acid 36 16

64-75-5 Tetracycline hydrochloride 46 16

64-77-7 Tolbutamide 47 16

66-75-1 Uracil mustard 49 17

@ 66-84-2 Glucosamine Hydrochloride +

Chondroitin Sulfate

(Primary CASRN is

GLUCOSCHONDN)

51 *

67-20-9 Nitrofurantoin 44 16

67-47-0 5-(Hydroxymethyl)-2-furfural 37 16

67-47-0 5-(Hydroxymethyl)-2-furfural 43 16

@ 67-56-1 Crude MCHM

(Primary CASRN is CRUDEMCHM)

32 5

67-64-1 Acetone 35 16

@ 67-64-1 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

@ 67-66-3 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

67-66-3 Chloroform 40 16

67-72-1 Halogenated ethanes CS

(Hexachloroethane)

36 16

67-72-1 Hexachloroethane 43 16

67-72-1 Hexachloroethane 43 16

68-12-2 Dimethylformamide 16

@ 68-26-8 Retinoid project 1

(Primary CASRN is RETINOID1)

53 *

69-65-8 D-Mannitol 44 16

@ 70-25-7 Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

(Primary CASRN is INIT/PROM)

43 16

@ 70-25-7 Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

(Primary CASRN is INIT/PROM)

43 16

@ 70-25-7 Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

(Primary CASRN is INIT/PROM)

43 16

70-30-4 Hexachlorophene 43 16

70-55-3 p-Toluenesulfonamide 34 14

71-43-2 Benzene 39 16

@ 71-43-2 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

71-43-2 Transgenic model evaluation II

(Benzene)

35 16

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

@ 71-55-6 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

71-55-6 Halogenated ethanes CS

(1,1,1-Trichloroethane)

37 16

71-55-6 1,1,1-Trichloroethane 47 16

71-55-6 1,1,1-Trichloroethane 37 16

72-20-8 Endrin 42 16

72-43-5 Methoxychlor 44 16

72-54-8 Tetrachlorodiphenylethane 46 16

72-55-9 p,p'-Dichlorodiphenyl

dichloroethylene

41 16

72-56-0 Di(p-ethylphenyl)dichloroethane 42 16

73-22-3 L-Tryptophan 47 16

73-31-4 Melatonin 51 *

73-31-4 Melatonin 51 *

73-31-4 Prevention 1 (Melatonin) 52 *

73-31-4 Prevention 2 (Melatonin) 52 *

@ 73-31-4 Prevention 2 (Silymarin +

melatonin)

(Primary CASRN is

SILYMARN+MEL)

52 *

73-31-4 Prevention 3 (Melatonin) 52 *

@ 73-31-4 Prevention 1 (Flaxseed oil +

melatonin)

(Primary CASRN is

FLAXSEED+MEL)

52 *

73-31-4 Prevention 4 (Melatonin) 52 *

73-31-4 Prevention 5 (Melatonin) 52 *

@ 73-31-4 Prevention 4 (Melatonin +

curcumin)

(Primary CASRN is

MEL+CURCUMIN)

52 *

@ 73-31-4 Prevention 4 (Melatonin + indole3-carbinol)

(Primary CASRN is

MEL+INDOLCAR)

52 *

74-83-9 Methyl bromide 38 16

74-83-9 Methyl bromide 44 16

74-83-9 Methyl bromide 38 16

74-94-2 Dimethylamine Borane 32 5

74-96-4 Bromoethane (ethyl bromide) 40 16

75-00-3 Chloroethane 40 16

75-05-8 Acetonitrile 49 *

75-05-8 Acetonitrile 38 16

@ 75-09-2 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

75-09-2 Methylene chloride 44 16

75-12-7 Formamide 36 16

75-12-7 Formamide 43 16

75-15-0 Carbon disulfide 50 *

75-15-0 Carbon disulfide 50 *

75-15-0 Carbon disulfide 50 *

75-21-8 Ethylene oxide 42 16

@ 75-25-2 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

75-25-2 Tribromomethane 47 16

75-27-4 Bromodichloromethane 40 16
Last Update: 09/18/2015 10:46 Management Status Report Page 58

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

75-27-4 Transgenic model evaluation

(Bromodichloromethane)

54 *

75-27-4 Transgenic model evaluation

(Bromodichloromethane)

54 *

75-27-4 Water disinfection byproducts

(Bromodichloromethane)

55 *

75-27-4 Water disinfection byproducts

(Bromodichloromethane)

55 *

75-27-4 Water disinfection byproducts

(Bromodichloromethane)

47 16

75-27-4 Water disinfection model

(Bromodichloromethane)

35 16

75-27-4 Water disinfection model

(Bromodichloromethane)

35 16

75-27-4 Water disinfection model

(Bromodichloromethane)

35 16

75-27-4 Water disinfection model

(Bromodichloromethane)

35 16

75-27-4 Water disinfection model

(Bromodichloromethane)

35 16

@ 75-34-3 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

75-34-3 1,1-Dichloroethane 41 16

@ 75-35-4 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

75-35-4 Vinylidene Chloride 47 16

75-35-4 Vinylidene Chloride 47 16

75-38-7 Vinylidene fluoride 55 *

75-47-8 Iodoform 43 16

75-52-5 Fish Project 1 (Nitromethane) 43 16

75-52-5 Fish Project 1 (Nitromethane) 43 16

75-52-5 Nitromethane 45 16

75-56-9 1,2-Propylene oxide 45 16

75-65-0 tert-Butyl alcohol 40 16

75-65-0 tert-Butyl alcohol 36 16

75-69-4 Trichlorofluoromethane 47 16

75-91-2 tert-Butyl hydroperoxide 50 *

75-91-2 tert-Butyl hydroperoxide 50 *

75-95-6 Halogenated ethanes CS

(Pentabromoethane)

36 16

76-01-7 Halogenated ethanes CS

(Pentachloroethane)

36 16

76-01-7 Pentachloroethane 45 16

76-06-2 Chloropicrin 40 16

76-12-0 Halogenated ethanes CS (1,2-

Difluoro-1,1,2,2-

tetrachloroethane)

36 16

76-22-2 DL-Camphor 50 *

76-44-8 Heptachlor 43 16

76-57-3 Codeine 38 16

76-57-3 Codeine 41 16

76-87-9 Triphenyltin hydroxide 47 16

77-09-8 Phenolphthalein 38 16

77-09-8 Phenolphthalein 45 16

77-09-8 Transgenic model evaluation II

(Phenolphthalein)

35 16

77-09-8 Transgenic model evaluation

(Phenolphthalein)

54 *

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

77-47-4 Hexachlorocyclopentadiene 43 16

77-65-6 Carbromal 40 16

77-79-2 3-Sulfolene 46 16

78-11-5 Pentaerythritol tetranitrate 45 16

78-34-2 Dioxathion 42 16

78-42-2 tris(2-Ethylhexyl)phosphate 47 16

78-44-4 Carisoprodol 50 *

78-44-4 Carisoprodol 36 16

78-44-4 Carisoprodol 16

78-59-1 Isophorone 43 16

78-79-5 Isoprene 37 16

78-79-5 Isoprene 43 16

78-79-5 Isoprene 16

78-84-2 Isobutyraldehyde 38 16

78-84-2 Isobutyraldehyde 43 16

78-87-5 1,2-Dichloropropane (propylene

dichloride)

41 16

@ 78-87-5 Pesticide/fertilizer

contamination--mixture 2

(Primary CASRN is

PESTFERTMIX2)

37 16

78-88-6 2,3-Dichloropropylene 51 *

78-94-4 Methyl vinyl ketone 52 *

79-00-5 1,1,2-Trichloroethane 47 16

@ 79-01-6 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

79-01-6 Trichloroethylene 47 16

79-01-6 Trichloroethylene 47 16

79-01-6 Trichloroethylene 47 16

79-01-6 Trichloroethylene 47 16

79-01-6 Trichloroethylene 54 *

79-01-6 Trichloroethylene 54 *

79-06-1 Acrylamide 38 16

79-06-1 Acrylamide 50 *

79-11-8 Monochloroacetic acid 44 16

79-27-6 Halogenated ethanes CS

(1,1,2,2-Tetrabromoethane)

37 16

79-34-5 Halogenated ethanes CS

(1,1,2,2-Tetrachloroethane)

37 16

79-34-5 1,1,2,2-Tetrachloroethane 46 16

79-34-5 1,1,2,2-Tetrachloroethane 37 16

79-34-5 1,1,2,2-Tetrachloroethane 53 *

79-34-5 1,1,2,2-Tetrachloroethane 37 16

79-43-6 Water disinfection byproducts

(Dichloroacetic acid)

55 *

79-43-6 Water disinfection model

(Dichloroacetic acid)

35 16

79-43-6 Water disinfection model

(Dichloroacetic acid)

35 16

79-43-6 Water disinfection model

(Dichloroacetic acid)

35 16

79-44-7 Dimethylcarbamoyl chloride 48 17

79-81-2 All-trans-retinyl palmitate 46 16

79-94-7 Tetrabromobisphenol A 53 *

79-94-7 Tetrabromobisphenol A 46 16

80-05-7 Bisphenol A 33 8
Last Update: 09/18/2015 10:46 Management Status Report Page 59

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

80-05-7 Bisphenol A 50 *

80-05-7 Bisphenol A 40 16

80-07-9 p,p'-Dichlorodiphenyl sulfone 38 16

80-07-9 p,p'-Dichlorodiphenyl sulfone 41 16

80-08-0 4,4'-Sulfonyldianiline (Dapsone) 46 16

80-09-1 Bisphenol S 31 4

80-15-9 Cumene hydroperoxide 51 *

80-56-8 alpha-Pinene 34 12

80-56-8 alpha-Pinene 33 7

80-62-6 Methyl methacrylate 44 16

81-49-2 1-Amino-2,4-dibromoanthraquinone 39 16

82-28-0 1-Amino-2-methylanthraquinone 39 16

82-68-8 Pentachloronitrobenzene 45 16

82-68-8 Pentachloronitrobenzene 45 16

83-79-4 Rotenone 49 17

83-79-4 Rotenone 46 16

83-79-4 Transgenic model evaluation

(Rotenone)

54 *

83-79-4 Transgenic model evaluation

(Rotenone)

54 *

84-65-1 Anthraquinone 39 16

84-66-2 Diethyl phthalate 42 16

@ 84-66-2 Diethyl phthalate/dimethyl

phthalate

(Primary CASRN is DIETH/

DIMETH)

42 16

84-74-2 Dibutyl Phthalate 33 10

84-74-2 Dibutyl Phthalate 36 16

84-74-2 Dibutyl Phthalate 36 16

84-74-2 Peroxisome project (Dibutyl

phthalate)

52 *

85-44-9 Phthalic anhydride 45 16

85-68-7 Butyl benzyl phthalate 40 16

85-68-7 Butyl benzyl phthalate 38 16

85-68-7 Butyl benzyl phthalate 40 16

86-30-6 N-Nitrosodiphenylamine 45 16

86-50-0 Azinphosmethyl 39 16

86-57-7 1-Nitronaphthalene 45 16

87-29-6 Cinnamyl anthranilate 41 16

87-62-7 2,6-Xylidine 48 16

87-66-1 Pyrogallol 46 16

87-68-3 Hexachloro-1,3-butadiene 37 16

87-86-5 Pentachlorophenol, Dowicide EC-7 45 16

87-86-5 Pentachlorophenol, DP-2 38 16

87-86-5 Pentachlorophenol, purified 38 16

87-86-5 Pentachlorophenol, purified 45 16

87-86-5 Pentachlorophenol, technical 45 16

87-86-5 Transgenic LECM

(Pentachlorophenol)

53 *

87-86-5 Transgenic LECM

(Pentachlorophenol)

53 *

88-06-2 2,4,6-Trichlorophenol 47 16

88-72-2 o-Nitrotoluene 37 16

88-72-2 o-Nitrotoluene 37 16

88-72-2 o-Nitrotoluene 45 16

88-73-3 2-Chloronitrobenzene 36 16

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

88-96-0 Phthalamide 45 16

89-25-8 1-Phenyl-3-methyl-5-pyrazolone 45 16

89-63-4 4-Chloro-2-nitroaniline 50 *

@ 89-78-1 DL-menthol

(Primary CASRN is 15356-70-4)

44 16

89-82-7 Pulegone 46 16

90-43-7 o-Phenylphenol 45 16

90-94-8 Michler's ketone 44 16

91-17-8 Decalin 41 16

91-20-3 Naphthalene 44 16

91-20-3 Naphthalene 44 16

91-23-6 o-Nitroanisole 38 16

91-23-6 o-Nitroanisole 44 16

91-53-2 Ethoxyquin 51 *

91-64-5 Coumarin 38 16

91-64-5 Coumarin 41 16

91-84-9 Pyrilamine 46 16

91-93-0 3,3'-Dimethoxybenzidine-4,4'-

diisocyanate

42 16

92-36-4 4-(6-Methyl-2-benzothiazolyl)-

benzenamine

52 *

92-48-8 Methyl coumarin 52 *

93-15-2 Methyleugenol 38 16

93-15-2 Methyleugenol 44 16

93-15-2 Methyleugenol (TGMX rat liver

evaluation)

52 *

@ 93-15-2 Toxicogenomics study of

allylbenzene & propenylbenzene

class flavor constituents (TGMX)

(Primary CASRN is

TGMXFLAVCLAS)

53 *

93-83-4 Oleic acid diethanolamine

condensate

45 16

93-83-4 Transgenic LECM (Oleic acid

diethanolamine condensate)

53 *

93-83-4 Transgenic LECM (Oleic acid

diethanolamine condensate)

53 *

94-13-3 Propyl-4-hydroxybenzoate 31 2

94-20-2 Chlorpropamide 41 16

@ 94-36-0 Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

(Primary CASRN is INIT/PROM)

43 16

@ 94-36-0 Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

(Primary CASRN is INIT/PROM)

43 16

@ 94-36-0 Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

(Primary CASRN is INIT/PROM)

43 16

94-52-0 6-Nitrobenzimidazole 44 16

@ 94-59-7 Toxicogenomics study of

allylbenzene & propenylbenzene

class flavor constituents (TGMX)

(Primary CASRN is

TGMXFLAVCLAS)

53 *

@ 94-60-0 Crude MCHM

(Primary CASRN is CRUDEMCHM)

32 5

94-75-7 Peroxisome project

(2,4-Dichlorophenoxyacetic acid)

52 *

95-06-7 Sulfallate 46 16

95-14-7 1,2,3-Benzotriazole 40 16

95-48-7 o-Cresol 36 16
Last Update: 09/18/2015 10:46 Management Status Report Page 60

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

95-50-1 1,2-Dichlorobenzene

(o-dichlorobenzene)

41 16

95-51-2 o-Chloroaniline 36 16

95-63-6 1,2,4-trimethylbenzene 32 4

95-74-9 3-Chloro-p-toluidine 40 16

95-79-4 5-Chloro-o-toluidine 40 16

95-80-7 2,4-Diaminotoluene (2,4-toluene

diamine)

41 16

95-80-7 Transgenic model evaluation

(2,4-Diaminotoluene)

54 *

95-80-7 Transgenic model evaluation

(2,4-Diaminotoluene)

54 *

95-83-0 4-Chloro-o-phenylenediamine 40 16

95-94-3 1,2,4,5-Tetrachlorobenzene 37 16

96-09-3 Styrene oxide 49 17

96-12-8 1,2-Dibromo-3-chloropropane 41 16

96-12-8 1,2-Dibromo-3-chloropropane 41 16

@ 96-12-8 Pesticide/fertilizer

contamination--mixture 2

(Primary CASRN is

PESTFERTMIX2)

37 16

96-13-9 2,3-Dibromo-1-propanol 41 16

96-18-4 Fish project 1

(1,2,3-Trichloropropane)

43 16

96-18-4 Fish project 1

(1,2,3-Trichloropropane)

43 16

96-18-4 1,2,3-Trichloropropane 54 *

96-18-4 1,2,3-Trichloropropane 47 16

96-29-7 Methyl ethyl ketoxime 37 16

96-45-7 Ethylene thiourea (ETU) 42 16

96-48-0 gamma-Butyrolactone 40 16

96-69-5 4,4-Thiobis(6-tert-butyl-mcresol)53 *

96-69-5 4,4-Thiobis(6-tert-butyl-mcresol)47 16

97-52-9 2-Methoxy-4-nitroaniline 52 *

97-53-0 Eugenol 42 16

@ 97-53-0 Toxicogenomics study of

allylbenzene & propenylbenzene

class flavor constituents (TGMX)

(Primary CASRN is

TGMXFLAVCLAS)

53 *

97-54-1 Isoeugenol 43 16

@ 97-54-1 Toxicogenomics study of

allylbenzene & propenylbenzene

class flavor constituents (TGMX)

(Primary CASRN is

TGMXFLAVCLAS)

53 *

97-77-8 Tetraethylthiuram disulfide 46 16

98-00-0 Furfuryl alcohol 38 16

98-00-0 Furfuryl alcohol 43 16

98-00-0 Transgenic LECM (Furfuryl

alcohol)

53 *

98-01-1 Furfural 43 16

98-29-3 p-tert-Butylcatechol 36 16

98-29-3 p-tert-Butylcatechol 36 16

98-56-6 p-Chloro-a,a,a-trifluorotoluene 50 *

98-56-6 p-Chloro-a,a,a-trifluorotoluene 33 10

98-56-6 p-Chloro-a,a,a-trifluorotoluene 36 16

98-56-6 p-Chloro-a,a,a-trifluorotoluene 36 16

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

98-82-8 Cumene 31 2

98-82-8 Cumene 41 16

98-83-9 alpha-Methylstyrene 52 *

98-83-9 alpha-Methylstyrene 44 16

98-85-1 alpha-Methylbenzyl alcohol 44 16

98-95-3 Nitrobenzene 52 *

@ 98-96-4 AZT + Pyrazinamide combination

(AIDS Initiative)

(Primary CASRN is AZTZINAMIDE)

35 16

98-96-4 Pyrazinamide 46 16

99-08-1 m-Nitrotoluene 37 16

99-55-8 5-Nitro-o-toluidine 45 16

99-56-9 4-Nitro-o-phenylenediamine 45 16

99-57-0 2-Amino-4-nitrophenol 39 16

99-59-2 5-Nitro-o-anisidine 44 16

99-97-8 N,N-Dimethyl-p-toluidine 33 10

99-97-8 N,N-Dimethyl-p-toluidine 51 *

99-97-8 N,N-Dimethyl-p-toluidine 42 16

99-99-0 p-Nitrotoluene 52 *

99-99-0 p-Nitrotoluene 37 16

99-99-0 p-Nitrotoluene 45 16

100-00-5 4-Chloronitrobenzene 36 16

100-01-6 p-Nitroaniline 38 16

100-01-6 p-Nitroaniline 44 16

100-02-7 p-Nitrophenol 45 16

100-40-3 4-Vinylcyclohexene 47 16

@ 100-41-4 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

100-41-4 Ethylbenzene 36 16

100-41-4 Ethylbenzene 42 16

100-42-5 Styrene 46 16

100-42-5 Styrene 53 *

100-44-7 Benzyl chloride 48 17

100-47-0 Benzonitrile 50 *

100-51-6 Benzyl alcohol 40 16

100-52-7 Benzaldehyde 39 16

100-64-1 Cyclohexanone oxime 36 16

101-05-3 Anilazine 39 16

101-20-2 Triclocarban 31 3

101-54-2 N-Phenyl-p-phenylenediamine 45 16

101-61-1 4,4'-Methylenebis(N,Ndimethyl)benzenamine44 16

101-80-4 4,4'-Oxydianiline 45 16

101-90-6 Diglycidyl resorcinol ether

(DGRE)

42 16

102-06-7 1,3-Diphenylguanidine 16

102-50-1 m-Cresidine 41 16

102-54-5 Ferrocene 51 *

102-71-6 Triethanolamine 54 *

102-71-6 Triethanolamine 54 *

102-71-6 Triethanolamine 54 *

102-71-6 Triethanolamine 47 16

102-71-6 Triethanolamine 47 16

102-96-5 beta-Nitrostyrene 45 16

103-23-1 Di(2-ethylhexyl)adipate 42 16
Last Update: 09/18/2015 10:46 Management Status Report Page 61

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

103-33-3 Azobenzene 39 16

103-85-5 1-Phenyl-2-thiourea 45 16

103-90-2 Acetaminophen

(4-hydroxyacetanilide)

38 16

103-90-2 Acetaminophen

(4-hydroxyacetanilide)

49 *

@ 104-46-1 Toxicogenomics study of

allylbenzene & propenylbenzene

class flavor constituents (TGMX)

(Primary CASRN is

TGMXFLAVCLAS)

53 *

104-55-2 Cinnamaldehyde 51 *

@ 105-08-8 Crude MCHM

(Primary CASRN is CRUDEMCHM)

32 5

105-11-3 p-Benzoquinone dioxime 40 16

105-55-5 N,N'-Diethylthiourea 42 16

105-60-2 Caprolactam 40 16

105-87-3 Geranyl acetate 43 16

106-44-5 p-Cresol 36 16

106-46-7 1,4-Dichlorobenzene

(p-dichlorobenzene)

41 16

106-47-8 p-Chloroaniline 40 16

106-49-0 p-Toluidine 33 10

106-87-6 4-Vinyl-1-cyclohexene diepoxide 47 16

106-88-7 1,2-Epoxybutane 42 16

106-89-8 Epichlorhydrin 48 17

106-92-3 Allyl glycidyl ether 38 16

106-93-4 1,2-Dibromoethane 41 16

106-93-4 1,2-Dibromoethane 41 16

@ 106-93-4 Pesticide/fertilizer

contamination--mixture 2

(Primary CASRN is

PESTFERTMIX2)

37 16

106-94-5 1-Bromopropane 40 16

106-95-6 Allyl bromide 35 16

106-95-6 Allyl bromide 50 *

106-95-6 Allyl bromide 35 16

106-99-0 1,3-Butadiene 40 16

106-99-0 1,3-Butadiene 50 *

106-99-0 1,3-Butadiene 40 16

106-99-0 1,3-Butadiene 48 17

107-02-8 Acrolein 35 16

107-05-1 Allyl chloride 38 16

@ 107-06-2 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

107-06-2 1,2-Dichloroethane 41 16

107-06-2 1,2-Dichloroethane 36 16

107-06-2 1,2-Dichloroethane 16

107-06-2 1,2-Dichloroethane 16

107-07-3 2-Chloroethanol (ethylene

chlorohydrin)

40 16

107-13-1 Acrylonitrile 38 16

107-18-6 Allyl alcohol 35 16

107-19-7 Propargyl alcohol 45 16

107-21-1 Ethylene glycol 42 16

107-22-2 Glyoxal 51 *

107-30-2 Chloromethyl methyl ether 48 17

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

108-10-1 Methyl isobutyl ketone 44 16

108-30-5 Succinic anhydride 46 16

108-39-4 m-Cresol 36 16

108-42-9 m-Chloroaniline 36 16

108-46-3 Resorcinol 46 16

108-46-3 Transgenic LEP (Resorcinol) 53 *

108-46-3 Transgenic model evaluation

(Resorcinol)

54 *

108-46-3 Transgenic model evaluation

(Resorcinol)

54 *

108-60-1 bis(2-Chloro-1-methylethyl) ether 40 16

108-60-1 bis(2-Chloro-1-methylethyl) ether 40 16

108-78-1 Melamine 44 16

@ 108-78-1 Melamine + Cyanuric Acid

combination

(Primary CASRN is MELCYANCOMB)

32 5

@ 108-78-1 Melamine + Cyanuric Acid

combination

(Primary CASRN is MELCYANCOMB)

51 *

@ 108-80-5 Melamine + Cyanuric Acid

combination

(Primary CASRN is MELCYANCOMB)

32 5

@ 108-80-5 Melamine + Cyanuric Acid

combination

(Primary CASRN is MELCYANCOMB)

51 *

108-86-1 Bromobenzene 50 *

108-86-1 Bromobenzene 50 *

@ 108-88-3 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

108-88-3 Toluene 47 16

108-88-3 Toluene 38 16

@ 108-90-7 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

108-90-7 Chlorobenzene 40 16

108-94-1 Cyclohexanone 48 17

@ 108-95-2 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

108-95-2 Phenol 45 16

108-99-6 beta-Picoline 45 16

109-09-1 o-Chloropyridine 50 *

109-09-1 o-Chloropyridine 34 14

109-69-3 n-Butyl chloride 40 16

109-86-4 Ethylene Glycol Monomethyl Ether

(EGMME)

36 16

109-86-4 Ethylene Glycol Monomethyl Ether

(EGMME)

36 16

109-89-7 Diethylamine 42 16

109-99-9 Tetrahydrofuran 53 *

109-99-9 Tetrahydrofuran 38 16

109-99-9 Tetrahydrofuran 46 16

110-00-9 Furan 33 8

110-00-9 Furan 43 16

110-02-1 Thiophene 53 *

110-54-3 n-Hexane 37 16

110-63-4 1,4-Butanediol 16

110-69-0 Butanal oxime 35 16
Last Update: 09/18/2015 10:46 Management Status Report Page 62

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

110-80-5 Ethylene glycol monoethyl ether

(EGMEE)

36 16

110-80-5 Ethylene glycol monoethyl ether

(EGMEE)

36 16

110-86-1 Pyridine 32 5

110-86-1 Pyridine 46 16

110-86-1 Pyridine 46 16

110-86-1 Transgenic LECM (Pyridine) 53 *

110-86-1 Transgenic LECM (Pyridine) 53 *

111-30-8 Glutaraldehyde 36 16

111-30-8 Glutaraldehyde 43 16

111-42-2 Diethanolamine 36 16

111-42-2 Diethanolamine 36 16

111-42-2 Diethanolamine 42 16

111-42-2 Transgenic LECM (diethanolamine) 54 *

111-76-2 2-Butoxyethanol (ethylene glycol

monobutyl ether)

36 16

111-76-2 2-Butoxyethanol (ethylene glycol

monobutyl ether)

36 16

111-76-2 2-Butoxyethanol (ethylene glycol

monobutyl ether)

40 16

111-91-1 bis(2-Chloroethoxy)methane 31 2

111-91-1 bis(2-Chloroethoxy)methane 40 16

111-91-1 bis(2-Chloroethoxy)methane 50 *

111-91-1 bis(2-Chloroethoxy)methane 50 *

113-92-8 Chlorpheniramine maleate 41 16

115-07-1 Propylene 45 16

115-11-7 Isobutene 43 16

115-28-6 Chlorendic acid 40 16

115-29-7 Endosulfan 42 16

115-32-2 Dicofol 41 16

115-86-6 Triphenyl Phosphate 31 2

115-86-6 Triphenyl Phosphate 32 5

115-96-8 Tris(2-Chloroethyl) Phosphate 47 16

116-06-3 Aldicarb 38 16

@ 116-06-3 Pesticide/fertilizer

contamination--mixture 2

(Primary CASRN is

PESTFERTMIX2)

37 16

116-14-3 Tetrafluoroethylene 38 16

116-14-3 Tetrafluoroethylene 46 16

117-08-8 Tetrachlorophthalic anhydride 37 16

117-39-5 Quercetin 46 16

117-79-3 2-Aminoanthraquinone 39 16

@ 117-81-7 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

117-81-7 Di(2-ethylhexyl) Phthalate 33 10

117-81-7 Di(2-ethylhexyl) Phthalate 33 10

117-81-7 Di(2-ethylhexyl) Phthalate 51 *

117-81-7 Di(2-ethylhexyl) Phthalate 51 *

117-81-7 Di(2-ethylhexyl) Phthalate 42 16

117-81-7 Transgenic model evaluation

(Di(2-ethylhexyl) phthalate)

54 *

117-81-7 Transgenic model evaluation

(Di(2-ethylhexyl) phthalate)

54 *

118-74-1 Hexachlorobenzene 34 14

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

118-92-3 o-Anthranilic acid 39 16

119-34-6 4-Amino-2-nitrophenol 39 16

119-53-9 Benzoin 39 16

119-61-9 Benzophenone 35 16

119-61-9 Benzophenone 39 16

119-64-2 Tetralin 46 16

119-84-6 3,4-Dihydrocoumarin 38 16

119-84-6 3,4-Dihydrocoumarin 42 16

120-32-1 o-Benzyl-p-chlorophenol 38 16

120-32-1 o-Benzyl-p-chlorophenol 40 16

120-32-1 o-Benzyl-p-chlorophenol 40 16

120-40-1 Lauric acid diethanolamine

condensate

43 16

120-40-1 Transgenic LECM (Lauric acid

diethanolamine condensate)

53 *

120-40-1 Transgenic LECM (Lauric acid

diethanolamine condensate)

53 *

@ 120-58-1 Toxicogenomics study of

allylbenzene & propenylbenzene

class flavor constituents (TGMX)

(Primary CASRN is

TGMXFLAVCLAS)

53 *

120-61-6 Dimethyl terephthalate 42 16

120-62-7 Piperonyl sulfoxide 45 16

120-71-8 p-Cresidine 41 16

120-71-8 p-Cresidine 51 *

120-71-8 Transgenic LEP (p-Cresidine) 53 *

120-83-2 2,4-Dichlorophenol 41 16

121-14-2 2,4-Dinitrotoluene 42 16

121-19-7 Roxarsone 46 16

121-44-8 Triethylamine 12

121-54-0 Benzethonium chloride 38 16

121-54-0 Benzethonium chloride 39 16

121-66-4 2-Amino-5-nitrothiazole 39 16

121-69-7 N,N-Dimethylaniline 42 16

121-75-5 Malathion 44 16

121-75-5 Malathion 44 16

121-79-9 Propyl gallate 46 16

121-88-0 2-Amino-5-nitrophenol 39 16

121-92-6 m-Nitrobenzoic acid 52 *

@ 122-34-9 Pesticide/fertilizer

contamination--mixture 2

(Primary CASRN is

PESTFERTMIX2)

37 16

122-34-9 Simazine 53 *

122-66-7 Hydrazobenzene 43 16

123-31-9 Hydroquinone 43 16

123-35-3 beta-Myrcene 44 16

123-72-8 Butyraldehyde 50 *

123-77-3 Azodicarbonamide 50 *

123-91-1 1,4-Dioxane 42 16

124-48-1 Chlorodibromomethane 40 16

124-64-1 Tetrakis(hydroxymethyl)phosphonium

chloride

46 16

125-33-7 Primidone (primaclone) 45 16

126-33-0 Sulfolane 33 6

126-33-0 Sulfolane 33 7
Last Update: 09/18/2015 10:46 Management Status Report Page 63

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

126-72-7 tris(2,3-Dibromopropyl) phosphate 47 16

126-98-7 Methacrylonitrile 16

126-98-7 Methacrylonitrile 44 16

126-99-8 Chloroprene 38 16

126-99-8 Chloroprene 40 16

126-99-8 Chloroprene 50 *

126-99-8 Chloroprene 50 *

127-00-4 1-Chloro-2-propanol, technical 36 16

127-00-4 1-Chloro-2-propanol, technical 50 *

127-00-4 1-Chloro-2-propanol, technical 40 16

127-00-4 Transgenic LECM

(1-Chloro-2-propanol, technical)

53 *

127-00-4 Transgenic LECM

(1-Chloro-2-propanol, technical)

53 *

127-07-1 Hydroxyurea 48 17

@ 127-18-4 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

127-18-4 Tetrachloroethylene 46 16

127-18-4 Tetrachloroethylene 46 16

@ 127-47-9 Retinoid project 1

(Primary CASRN is RETINOID1)

53 *

127-47-9 Retinoid project 3 (Retinol

acetate)

53 *

127-69-5 Sulfisoxazole 46 16

128-37-0 Butylated hydroxytoluene 40 16

128-66-5 C.I. Vat Yellow 4 41 16

129-15-7 2-Methyl-1-nitroanthraquinone 44 16

129-15-7 2-Methyl-1-nitroanthraquinone 48 17

129-73-7 Leucomalachite green 43 16

129-73-7 Leucomalachite green 37 16

129-79-3 2,4,7-Trinitro-fluoren-9-one 37 16

129-79-3 2,4,7-Trinitro-fluoren-9-one 37 16

130-17-6 2-(4-Aminophenyl)-6-methyl-7-

benzothiazole sulfonic acid

50 *

@ 131-11-3 Diethyl phthalate/dimethyl

phthalate

(Primary CASRN is DIETH/

DIMETH)

42 16

131-17-9 Diallyl phthalate 41 16

131-17-9 Diallyl phthalate 41 16

131-57-7 2-Hydroxy-4-methoxybenzophenone 33 10

131-57-7 2-Hydroxy-4-methoxybenzophenone 37 16

131-57-7 2-Hydroxy-4-methoxybenzophenone 37 16

131-57-7 2-Hydroxy-4-methoxybenzophenone 37 16

132-32-1 3-Amino-9-ethylcarbazole 48 17

132-98-9 Penicillin VK 45 16

133-06-2 Captan 40 16

133-90-4 Chloramben 40 16

134-29-2 o-Anisidine hydrochloride 39 16

134-50-9 9-Aminoacridine hydrochloride 50 *

134-50-9 9-Aminoacridine hydrochloride 50 *

134-72-5 Ephedrine sulfate 42 16

135-20-6 Cupferron 41 16

135-23-9 Methapyrilene hydrochloride 48 17

135-23-9 Methapyrilene hydrochloride 52 *

135-23-9 Methapyrilene hydrochloride 37 16

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

135-88-6 N-Phenyl-2-naphthylamine 45 16

136-35-6 Diazoaminobenzene 36 16

136-40-3 Phenazopyridine hydrochloride 45 16

136-45-8 2,5-Pyridinedicarboxylic Acid,

Dipropyl Ester

52 *

136-77-6 4-Hexylresorcinol 43 16

137-09-7 2,4-Diaminophenol dihydrochloride 41 16

137-17-7 2,4,5-Trimethylaniline 47 16

137-30-4 Ziram 48 16

139-13-9 Nitrilotriacetic acid (NTA) 44 16

139-65-1 4,4'-Thiodianiline 47 16

139-94-6 Nithiazide 44 16

140-11-4 Benzyl acetate 40 16

140-11-4 Benzyl acetate 40 16

@ 140-11-4 Benzyl acetate + glycine

combination study

(Primary CASRN is

GLYCINEBENZA)

50 *

140-49-8 4-(Chloroacetyl)acetanilide 40 16

140-56-7 Formulated fenaminosulf 42 16

140-67-0 Estragole 51 *

140-67-0 Estragole 36 16

@ 140-67-0 Toxicogenomics study of

allylbenzene & propenylbenzene

class flavor constituents (TGMX)

(Primary CASRN is

TGMXFLAVCLAS)

53 *

140-88-5 Ethyl acrylate 42 16

142-04-1 Aniline hydrochloride 39 16

142-46-1 2,5-Dithiobiurea 42 16

142-83-6 2,4-Hexadienal 38 16

142-83-6 2,4-Hexadienal 43 16

143-33-9 Sodium cyanide 16

143-50-0 Chlordecone 40 16

147-24-0 Diphenhydramine hydrochloride 42 16

147-47-7 1,2-Dihydro-2,2,4-

trimethylquinoline (monomer)

38 16

147-47-7 1,2-Dihydro-2,2,4-

trimethylquinoline (monomer)

42 16

147-47-7 1,2-Dihydro-2,2,4-

trimethylquinoline (monomer)

38 16

147-47-7 1,2-Dihydro-2,2,4-

trimethylquinoline (monomer)

42 16

147-94-4 Cytarabine 48 17

148-18-5 Sodium diethyldithiocarbamate 46 16

148-24-3 8-Hydroxyquinoline 43 16

148-24-3 Transgenic model evaluation

(8-Hydroxyquinoline)

54 *

148-24-3 Transgenic model evaluation

(8-Hydroxyquinoline)

54 *

148-82-3 Melphalan 48 17

148-82-3 Transgenic LEP (Melphalan) 53 *

148-82-3 Transgenic model evaluation

(Melphalan)

54 *

148-82-3 Transgenic model evaluation

(Melphalan)

54 *

148-82-3 Transgenic model evaluation

(Melphalan)

54 *
Last Update: 09/18/2015 10:46 Management Status Report Page 64

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

148-82-3 Transgenic model evaluation

(Melphalan)

54 *

148-82-3 Transgenic model evaluation

(Melphalan)

54 *

149-30-4 2-Mercaptobenzothiazole 44 16

150-38-9 Trisodium

ethylenediaminetetraacetate

trihydrate (EDTA)

47 16

150-68-5 Monuron 44 16

154-69-8 Tripelennamine hydrochloride 54 *

154-93-8 1,3-bis(Chloroethyl)-1-

nitrosourea

48 17

156-10-5 p-Nitrosodiphenylamine 45 16

156-59-2 cis-1,2-Dichloroethylene 51 *

@ 156-60-5 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

156-60-5 trans-1,2-Dichloroethylene 51 *

156-60-5 trans-1,2-Dichloroethylene 51 *

156-60-5 trans-1,2-Dichloroethylene 36 16

156-62-7 Calcium cyanamide 40 16

262-12-4 Dibenzo-p-dioxin 41 16

271-89-6 Benzofuran 39 16

286-20-4 Cyclohexene oxide 51 *

286-20-4 Cyclohexene oxide 51 *

286-20-4 Cyclohexene oxide 51 *

298-00-0 Methyl parathion 44 16

298-59-9 Methylphenidate hydrochloride 38 16

298-59-9 Methylphenidate hydrochloride 44 16

298-59-9 Transgenic model evaluation

(Methylphenidate hydrochloride)

54 *

298-81-7 8-Methoxypsoralen 44 16

@ 299-42-3 Ephedrine + caffeine combination

(Primary CASRN is EPHEDCOMBO)

51 *

@ 299-42-3 Ephedrine + caffeine combination

(Primary CASRN is EPHEDCOMBO)

51 *

@ 301-04-2 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

301-04-2 Lead(2+) acetate 51 *

@ 301-04-2 Lead contaminated soil

(Primary CASRN is

PBCONTAMSOIL)

51 *

302-17-0 Chloral hydrate 40 16

302-17-0 Chloral hydrate 36 16

302-17-0 Chloral hydrate 40 16

303-34-4 Lasiocarpine 43 16

303-47-9 Ochratoxin A 45 16

305-03-3 Chlorambucil 48 17

306-37-6 1,2-Dimethylhydrazine 2HCl 48 17

307-24-4 Perfluorohexanoic acid (PFHXA) 33 6

309-00-2 Aldrin 38 16

315-18-4 Mexacarbate 44 16

316-42-7 Emetine hydrochloride 42 16

320-67-2 5-Azacytidine 39 16

333-41-5 Diazinon 41 16

335-67-1 Perfluorooctanoic Acid 33 10

335-67-1 Perfluorooctanoic Acid 33 10

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

335-67-1 Perfluorooctanoic Acid 52 *

335-67-1 Perfluorooctanoic Acid 33 6

335-76-2 Perfluorodecanoic Acid 33 6

342-69-8 6-Methylmercaptopurine

ribonucleoside

48 17

354-58-5 Halogenated ethanes CS (1,1,1-

Trichloro-2,2,2-trifluoroethane)

37 16

366-70-1 Procarbazine hydrochloride 49 17

366-70-1 Procarbazine hydrochloride 45 16

367-51-1 Sodium thioglycolate 34 14

375-73-5 Perfluorobutane sulfonate (PFBS) 33 6

375-95-1 Perfluorononanoic Acid 33 6

389-08-2 Nalidixic acid 44 16

396-01-0 Triamterene 54 *

396-01-0 Triamterene 47 16

431-03-8 2,3-Butanedione 33 10

434-07-1 Oxymetholone 52 *

434-07-1 Oxymetholone 45 16

434-13-9 Lithocholic acid 44 16

446-72-0 Endocrine disruptor (Genistein) 42 16

446-86-6 Azathioprine 48 17

458-37-7 Prevention 4 (Curcumin) 52 *

@ 458-37-7 Prevention 4 (Melatonin +

curcumin)

(Primary CASRN is

MEL+CURCUMIN)

52 *

462-08-8 3-Aminopyridine 50 *

@ 462-08-8 Comparison study of

Aminopyridines/Troponin levels

(Primary CASRN is

AMINOPYRCOMP)

50 *

469-21-6 Doxylamine 42 16

470-82-6 1,8-Cineol 50 *

470-82-6 1,8-Cineol 51 *

@ 471-15-8 alpha/beta Thujone mixture

(Primary CASRN is 76231-76-0)

37 16

@ 471-15-8 alpha/beta Thujone mixture

(Primary CASRN is 76231-76-0)

47 16

481-72-1 Aloe-emodin 39 16

486-12-4 Triprolidine 47 16

488-41-5 Dibromomannitol 48 17

501-36-0 Resveratrol 33 8

504-24-5 4-Aminopyridine 50 *

@ 504-24-5 Comparison study of

Aminopyridines/Troponin levels

(Primary CASRN is

AMINOPYRCOMP)

50 *

504-29-0 2-Aminopyridine 50 *

@ 504-29-0 Comparison study of

Aminopyridines/Troponin levels

(Primary CASRN is

AMINOPYRCOMP)

50 *

504-88-1 3-Nitropropionic acid 45 16

509-14-8 Tetranitromethane 46 16

510-15-6 Chlorobenzilate 40 16

512-56-1 Trimethylphosphate 47 16

513-37-1 Dimethylvinyl chloride (DMVC) 42 16

513-86-0 Acetoin 34 14
Last Update: 09/18/2015 10:46 Management Status Report Page 65

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

@ 514-78-3 Retinoid project 1

(Primary CASRN is RETINOID1)

53 *

518-82-1 Emodin 42 16

528-74-5 Dichloromethotrexate 48 17

531-76-0 Merphalan 48 17

531-85-1 Benzidine dihydrochloride 50 *

532-27-4 2-Chloroacetophenone (CN) 40 16

536-33-4 Ethionamide 42 16

538-23-8 Tricaprylin 47 16

538-75-0 Dicyclohexylcarbodiimide 35 16

538-75-0 Dicyclohexylcarbodiimide 35 16

538-75-0 Dicyclohexylcarbodiimide 35 16

540-59-0 cis & trans 1,2-Dichloroethylene 51 *

542-56-3 Isobutyl nitrite 43 16

542-75-6 1,3-Dichloropropene (Telone II) 41 16

542-88-1 bis(Chloromethyl) ether 48 17

546-80-5 alpha-Thujone 37 16

@ 546-80-5 alpha/beta Thujone mixture

(Primary CASRN is 76231-76-0)

37 16

@ 546-80-5 alpha/beta Thujone mixture

(Primary CASRN is 76231-76-0)

47 16

548-62-9 Hexamethyl-p-rosaniline chloride 43 16

548-62-9 Hexamethyl-p-rosaniline chloride 43 16

552-30-7 Trimellitic anhydride 54 *

552-30-7 Trimellitic anhydride 54 *

556-52-5 Glycidol 43 16

556-52-5 Transgenic model evaluation II

(Glycidol)

35 16

563-47-3 3-Chloro-2-methylpropene 40 16

569-61-9 C.I. Basic Red 9

Monohydrochloride

41 16

569-64-2 Malachite green 44 16

569-64-2 Malachite green 37 16

583-39-1 2-Mercaptobenzimidazole 51 *

583-39-1 2-Mercaptobenzimidazole 51 *

591-87-7 Allyl acetate 35 16

597-25-1 Dimethyl

morpholinophosphoramidate

42 16

598-55-0 Methyl carbamate 44 16

599-79-1 Salicylazosulfapyridine 38 16

599-79-1 Salicylazosulfapyridine 46 16

600-14-6 2,3-Pentanedione 34 12

602-87-9 5-Nitroacenaphthene 44 16

604-75-1 Oxazepam 45 16

604-75-1 Oxazepam 45 16

607-91-0 Myristicin 52 *

@ 607-91-0 Toxicogenomics study of

allylbenzene & propenylbenzene

class flavor constituents (TGMX)

(Primary CASRN is

TGMXFLAVCLAS)

53 *

608-93-5 Pentachlorobenzene 37 16

609-20-1 2,6-Dichloro-p-phenylenediamine 41 16

611-14-3 2-ethyltoluene 31 2

612-82-8 3,3'-Dimethylbenzidine

dihydrochloride

42 16

614-45-9 tert-Butyl perbenzoate 36 16

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

616-91-1 Antioxidant model (TRAMP) -

N-acetylcysteine

50 *

619-17-0 4-Nitroanthranilic acid 44 16

620-14-4 3-ethyltoluene 31 2

622-51-5 p-Tolylurea 49 17

622-96-8 4-ethyltoluene 31 2

624-18-0 p-Phenylenediamine

dihydrochloride

45 16

624-83-9 Methyl isocyanate 48 17

628-02-4 Hexanamide 48 17

630-16-0 Halogenated ethanes CS

(1,1,1,2-Tetrabromoethane)

36 16

630-20-6 Halogenated ethanes CS

(1,1,1,2-Tetrachloroethane)

37 16

630-20-6 1,1,1,2-Tetrachloroethane 46 16

631-64-1 Water disinfection byproducts

(Dibromoacetic acid)

55 *

631-64-1 Water disinfection byproducts

(Dibromoacetic acid)

47 16

636-21-5 o-Toluidine hydrochloride 47 16

636-21-5 o-Toluidine hydrochloride 37 16

643-22-1 Erythromycin stearate 42 16

643-79-8 ortho-Phthalaldehyde 34 12

678-39-7 Fluorotelomer Alcohol 8+2 31 3

693-13-0 Diisopropylcarbodiimide 38 16

693-13-0 Diisopropylcarbodiimide 35 16

693-13-0 Diisopropylcarbodiimide 35 16

693-13-0 Diisopropylcarbodiimide 42 16

693-98-1 2-Methylimidazole 37 16

693-98-1 2-Methylimidazole 44 16

700-06-1 Indole-3-carbinol 34 12

700-06-1 Indole-3-carbinol 34 14

700-06-1 Prevention 4 (Indole-3-carbinol) 52 *

@ 700-06-1 Prevention 4 (Melatonin + indole3-carbinol)

(Primary CASRN is

MEL+INDOLCAR)

52 *

@ 723-46-6 AZT + TMP/SMX (mixture)

combination

(Primary CASRN is AZTTMPSMX)

50 *

@ 723-46-6 AZT + TMP/SMX (mixture)

combination

(Primary CASRN is AZTTMPSMX)

50 *

@ 738-70-5 AZT + TMP/SMX (mixture)

combination

(Primary CASRN is AZTTMPSMX)

50 *

@ 738-70-5 AZT + TMP/SMX (mixture)

combination

(Primary CASRN is AZTTMPSMX)

50 *

756-79-6 Dimethyl methylphosphonate 42 16

770-35-4 Propylene glycol phenyl ether 32 5

789-61-7 beta-Thioguanidine deoxyriboside 47 16

822-36-6 4-Methylimidazole 37 16

822-36-6 4-Methylimidazole 44 16

828-00-2 Dimethoxane 42 16

834-12-8 Ametryn 50 *

834-28-6 Phenformin hydrochloride 45 16

842-07-9 C.I. Solvent Yellow 14 41 16

865-21-4 Vinblastine 49 17
Last Update: 09/18/2015 10:46 Management Status Report Page 66

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

868-85-9 Dimethyl hydrogen phosphite 42 16

924-42-5 N-Methylolacrylamide 44 16

924-42-5 Transgenic model evaluation

(N-Methylolacrylamide)

54 *

924-42-5 Transgenic model evaluation

(N-Methylolacrylamide)

54 *

930-68-7 2-Cyclohexen-1-one 51 *

952-23-8 Proflavin hydrochloride 45 16

959-24-0 QT drugs (sotalol hydrochloride) 53 *

961-11-5 Tetrachlorvinphos 46 16

968-81-0 Acetohexamide 38 16

982-57-0 Chloramphenicol sodium succinate 50 *

989-38-8 Rhodamine 6G 46 16

989-51-5 Antioxidant model (TRAMP) -

Epigallocatechin gallate

50 *

999-81-5 2-Chloroethyltrimethylammonium

chloride

40 16

1067-33-0 Dibutyltin diacetate 41 16

1071-83-6 Glyphosate 36 16

1071-83-6 Glyphosate 36 16

@ 1095-90-5 AZT + Methadone HCl (AIDS)

(Primary CASRN is AZTMETHCOMB)

50 *

1116-54-7 N-Nitrosodiethanolamine 49 17

1124-64-7 Ionic Liquid: N-Butylpyridinium

Chloride

32 5

@ 1124-64-7 Ionic liquid Toxicity

(Primary CASRN is

IONICLIQUIDS)

51 *

1156-19-0 Tolazamide 47 16

1162-65-8 Aflatoxin B1 (TGMX) 32 5

1163-19-5 Decabromodiphenyl ether 41 16

1212-29-9 N,N'-Dicyclohexylthiourea 41 16

1241-94-7 2-Ethylhexyl Diphenyl Phosphate 51 *

1271-19-8 Titanocene dichloride 47 16

1300-72-7 Sodium xylenesulfonate 38 16

1300-72-7 Sodium xylenesulfonate 46 16

1303-00-0 Gallium arsenide 38 16

1303-00-0 Gallium arsenide 43 16

1306-19-0 Cadmium oxide 36 16

1306-19-0 Cadmium oxide 36 16

1309-64-4 Antimony Trioxide 34 13

1313-27-5 Molybdenum trioxide 38 16

1313-27-5 Molybdenum trioxide 44 16

1313-99-1 Nickel (II) oxide 44 16

1314-35-8 Tungsten trioxide 32 4

1314-62-1 Vanadium pentoxide 38 16

1314-62-1 Vanadium pentoxide 47 16

@ 1314-87-0 Lead contaminated soil

(Primary CASRN is

PBCONTAMSOIL)

51 *

1314-87-0 Lead sulfide 51 *

1314-87-0 Lead sulfide 51 *

1317-36-8 Lead oxide 51 *

1317-80-2 Nanoscale material (Rutile

titanium dioxide)

52 *

1318-09-8 Libby Amphibole 32 4

1319-77-3 Cresols 36 16

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

1319-77-3 Cresols 41 16

1321-74-0 Divinylbenzene 51 *

1321-74-0 Divinylbenzene 42 16

@ 1327-53-3 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

1328-53-6 C.I. Phthalocyanine green 50 *

@ 1330-20-7 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

1330-20-7 Xylenes (mixed) 48 16

1330-78-5 Tricresyl Phosphate 54 *

1330-78-5 Tricresyl Phosphate 31 2

1330-78-5 Tricresyl Phosphate 54 *

1330-78-5 Tricresyl Phosphate 47 16

@ 1333-82-0 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

1338-23-4 Methyl ethyl ketone peroxide 37 16

1420-04-8 Clonitralid 41 16

1455-77-2 Guanazole 48 17

1465-25-4 N-(1-Naphthyl)ethylenediamine

dihydrochloride

44 16

1582-09-8 Trifluralin 47 16

1596-84-5 Daminozide 41 16

1617-90-9 Vincamine 55 *

1629-58-9 Ethyl vinyl ketone 51 *

1634-78-2 Malaoxon 44 16

@ 1646-87-3 Pesticide/fertilizer

contamination--mixture 2

(Primary CASRN is

PESTFERTMIX2)

37 16

@ 1646-88-4 Pesticide/fertilizer

contamination--mixture 2

(Primary CASRN is

PESTFERTMIX2)

37 16

1649-08-7 Halogenated ethanes CS

(1,2-Dichloro-1,1-difluoroethane)

36 16

1746-01-6 Toxic equivalency factor

evaluation (TCDD)

46 16

1746-01-6 TEF transgenics (TCDD) 53 *

1746-01-6 2,3,7,8-Tetrachlorodibenzo-pdioxin46 16

1746-01-6 2,3,7,8-Tetrachlorodibenzo-pdioxin46 16

@ 1746-01-6 Toxic equivalency factor

evaluation (Dioxin mixture)

(Primary CASRN is

TEFDIOXINMIX)

47 16

1746-01-6 Transgenic Model Evaluation

(2,3,7,8-

Tetrachlorodibenzodioxin)

54 *

1746-01-6 Transgenic Model Evaluation

(2,3,7,8-

Tetrachlorodibenzodioxin)

54 *

1746-01-6 Transgenic Model Evaluation

(2,3,7,8-

Tetrachlorodibenzodioxin)

54 *

1746-01-6 Transgenic Model Evaluation

(2,3,7,8-

Tetrachlorodibenzodioxin)

54 *

1747-60-0 6-Methoxy-2-benzothiazolamine 52 *
Last Update: 09/18/2015 10:46 Management Status Report Page 67

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

1763-23-1 Perfluorooctane Sulfonate 33 6

1777-84-0 3-Nitro-p-acetophenetide 44 16

1825-21-4 Pentachloroanisole 45 16

1836-75-5 Nitrofen 44 16

1836-75-5 Nitrofen 44 16

1896-62-4 Methyl trans-styryl ketone 52 *

1896-62-4 Methyl trans-styryl ketone 52 *

1896-62-4 Methyl trans-styryl ketone 44 16

1897-45-6 Chlorothalonil 40 16

@ 1912-24-9 Pesticide/fertilizer

contamination--mixture 2

(Primary CASRN is

PESTFERTMIX2)

37 16

@ 1912-24-9 Pesticide/fertilizer

contamination--mixture 3

(Primary CASRN is

PESTFERTMIX3)

37 16

1918-02-1 Picloram 45 16

1936-15-8 C.I. Acid Orange 10 41 16

1937-37-7 C.I. Direct Black 38 36 16

1948-33-0 t-Butylhydroquinone 40 16

1955-45-9 Pivalolactone 45 16

1972-08-3 1-trans-delta-9-

Tetrahydrocannabinol

38 16

1972-08-3 1-trans-delta-9-

Tetrahydrocannabinol

46 16

1982-37-2 Methdilazine 52 *

2058-46-0 Oxytetracycline hydrochloride 45 16

2164-17-2 Fluometuron 43 16

2185-92-4 2-Biphenylamine hydrochloride 40 16

2243-62-1 1,5-Naphthalenediamine 44 16

2244-16-8 D-Carvone 40 16

2385-85-5 Mirex 44 16

2425-85-6 C.I. Pigment Red 3 41 16

2426-08-6 n-Butyl Glycidyl Ether 50 *

2429-74-5 C.I. Direct Blue 15 41 16

2432-99-7 11-Aminoundecanoic acid 39 16

2438-88-2 2,3,5,6-Tetrachloro-4-

nitroanisole

46 16

2440-22-4 Phenolic Benzotriazoles

(Drometrizole)

32 4

2475-45-8 C.I. Disperse Blue 1 41 16

2489-77-2 Trimethylthiourea 47 16

2602-46-2 C.I. Direct Blue 6 36 16

2602-46-2 C.I. Direct Blue 6 50 *

2608-48-2 5-(4-Nitrophenyl)-2,4-pentadien1-al (NPPD)52 *

2608-48-2 5-(4-Nitrophenyl)-2,4-pentadien1-al (NPPD)52 *

2698-41-1 o-Chlorobenzalmalononitrile (CS) 40 16

2757-90-6 Agaritine 48 17

2783-94-0 FD & C Yellow No. 6 42 16

2784-94-3 HC Blue 1 43 16

2832-40-8 C.I. Disperse Yellow 3 41 16

2835-39-4 Allyl isovalerate 39 16

2835-95-2 5-Amino-o-cresol 34 14

2871-01-4 HC Red 3 43 16

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

3147-75-9 Phenolic Benzotriazoles

(Octrizole)

32 4

3147-76-0 Phenolic Benzotriazoles (2-(2HBenzotriazol-2-yl)-4-tertbutylphenol)31 4

3165-93-3 4-Chloro-o-toluidine

hydrochloride

40 16

3252-43-5 Water disinfection byproducts

(Dibromoacetonitrile)

47 16

3296-90-0 2,2-bis(Bromomethyl)-1,3-

propanediol

50 *

3296-90-0 2,2-bis(Bromomethyl)-1,3-

propanediol

38 16

3296-90-0 2,2-bis(Bromomethyl)-1,3-

propanediol

40 16

3296-90-0 Fish project 1 (2,2-

bis(Bromomethyl)-1,3-propanediol)

42 16

3296-90-0 Fish project 1 (2,2-

bis(Bromomethyl)-1,3-propanediol)

43 16

3380-34-5 Triclosan 54 *

3380-34-5 Triclosan 33 7

3416-24-8 Glucosamine 51 *

3458-22-8 IPD (3,3'-iminobis-1-propanol

dimethanesulfonate (ester)

hydrochloride)

43 16

3524-68-3 Pentaerythritol triacrylate 35 16

3524-68-3 Pentaerythritol triacrylate 35 16

3546-10-9 Phenesterin 45 16

3567-69-9 C.I. Acid Red 14 41 16

3622-84-2 N-Butylbenzenesulfonamide 32 5

3778-73-2 Isophosphamide 43 16

3864-99-1 Phenolic Benzotriazoles (2-(5-

Chloro-2Hbenzotriazol-2-yl)-

4,6bis(1,1 dimethylethyl)phenol)

32 4

3871-99-6 Perfluorohexane sulfonate

potassium salt (PFHSKslt)

32 5

3896-11-5 Phenolic Benzotriazoles

(Bumetrizole)

32 4

4170-30-3 Crotonaldehyde 51 *

4320-30-3 L-Arginine Glutamate 48 17

4342-03-4 Dacarbazine 48 17

4465-94-5 Cytoxal alcohol 48 17

5131-60-2 4-Chloro-m-phenylenediamine 40 16

5160-02-1 D&C Red No. 9 41 16

5263-02-5 Zinc Carbonate, Basic 33 10

5307-14-2 2-Nitro-p-phenylenediamine 45 16

5392-40-5 Citral 41 16

5392-40-5 Citral 51 *

5392-40-5 Citral 51 *

5407-04-5 Dimethylaminopropyl chloride,

hydrochloride

51 *

5407-04-5 Dimethylaminopropyl chloride,

hydrochloride

36 16

@ 5436-43-1 BDE Toxicogenomics Study (TGMX)

(Primary CASRN is

TGMXBDECLASS)

31 2

5436-43-1 2,2',4,4'-Tetrabromodiphenyl

Ether (BDE-47)

53 *

5436-43-1 2,2',4,4'-Tetrabromodiphenyl

Ether (BDE-47)

31 2
Last Update: 09/18/2015 10:46 Management Status Report Page 68

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

5436-43-1 2,2',4,4'-Tetrabromodiphenyl

Ether (BDE-47)

32 4

5522-43-0 1-Nitropyrene 37 16

5589-96-8 Water disinfection byproducts

(Bromochloroacetic acid)

47 16

5634-39-9 Iodinated glycerol 43 16

5694-00-8 Glycidamide 43 16

@ 5743-04-4 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

5989-27-5 D-Limonene 44 16

@ 6018-89-9 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

6055-19-2 Transgenic model evaluation

(Cyclophosphamide monohydrate)

54 *

6055-19-2 Transgenic model evaluation

(Cyclophosphamide monohydrate)

54 *

6055-52-3 1,6-Hexanediamine dihydrochloride 37 16

6055-52-3 1,6-Hexanediamine dihydrochloride 37 16

6109-97-3 3-Amino-9-ethylcarbazole HCl 39 16

6317-18-6 Methylene bis(thiocyanate) 37 16

6358-85-6 Diarylanilide yellow 41 16

6369-59-1 2,5-Toluenediamine sulfate 47 16

6373-74-6 C.I. Acid Orange 3 41 16

6425-39-4 2,2'-Dimorpholinodiethyl Ether 31 3

6459-94-5 C.I. Acid Red 114 41 16

6471-49-4 C.I. Pigment Red 23 41 16

@ 6484-52-2 Pesticide/fertilizer

contamination--mixture 2

(Primary CASRN is

PESTFERTMIX2)

37 16

@ 6484-52-2 Pesticide/fertilizer

contamination--mixture 3

(Primary CASRN is

PESTFERTMIX3)

37 16

6533-68-2 Scopolamine hydrobromide

trihydrate

38 16

6533-68-2 Scopolamine hydrobromide

trihydrate

53 *

6533-68-2 Scopolamine hydrobromide

trihydrate

46 16

6959-47-3 2-Chloromethylpyridine

hydrochloride

40 16

6959-48-4 3-Chloromethylpyridine

hydrochloride

40 16

7008-42-6 Acronycine 38 16

7166-19-0 beta-Bromo-beta-nitrostyrene 35 16

7177-48-2 Ampicillin trihydrate 39 16

7220-79-3 Methylene blue trihydrate 52 *

7220-79-3 Methylene blue trihydrate 52 *

7220-79-3 Methylene blue trihydrate 44 16

7336-20-1 4,4'-Diamino-2,2'-

stilbenedisulfonic acid, disodium

salt

41 16

@ 7439-92-1 Lead contaminated soil

(Primary CASRN is

PBCONTAMSOIL)

51 *

7440-22-4 Nanoscale Silver 32 5

7440-33-7 Tungsten 32 5

7440-47-3 Chromium 48 17

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

7440-48-4 Cobalt 41 16

7446-34-6 Selenium sulfide 46 16

7446-34-6 Selenium sulfide 46 16

@ 7481-89-2 3'-Azido-3'-deoxythymidine and

2',3'-Dideoxycytidine

(Primary CASRN is AZTDDCCOMB)

50 *

7481-89-2 2',3'-Dideoxycytidine 51 *

7481-89-2 2',3'-Dideoxycytidine 51 *

7481-89-2 2',3'-Dideoxycytidine 51 *

@ 7481-89-2 Interferon AD + ddC (AIDS

Initiative)

(Primary CASRN is INTDDCCOMB)

51 *

@ 7487-94-7 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

7487-94-7 Mercuric chloride 44 16

7562-61-0 (+)-Usnic Acid 33 6

7632-00-0 Sodium nitrite 38 16

7632-00-0 Sodium nitrite 46 16

7681-49-4 Sodium Fluoride 46 16

7681-49-4 Sodium Fluoride 49 17

@ 7681-52-9 Chloraminated water

(Primary CASRN is

CHLORAMINEMX)

40 16

@ 7681-52-9 Chlorinated water

(Primary CASRN is

CHLORWATERMX)

40 16

7758-99-8 Cupric sulfate 36 16

7758-99-8 Cupric sulfate 36 16

7772-99-8 Stannous chloride 46 16

7775-09-9 Water disinfection byproducts

(Sodium chlorate)

47 16

@ 7782-50-5 Chlorinated water

(Primary CASRN is

CHLORWATERMX)

40 16

7784-42-1 Arsine 50 *

@ 7784-46-5 Arsenic antioxidant mixture

(Primary CASRN is

ANTIOXCOMBO2)

50 *

@ 7784-46-5 Arsenic antioxidant mixture

(Primary CASRN is

ANTIOXCOMBO2)

50 *

@ 7786-81-4 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

7789-12-0 Sodium dichromate dihydrate (VI) 46 16

7789-12-0 Sodium dichromate dihydrate (VI) 37 16

7789-38-0 Water disinfection model (Sodium

bromate)

35 16

7789-38-0 Water disinfection model (Sodium

bromate)

35 16

7789-38-0 Water disinfection model (Sodium

bromate)

35 16

7803-51-2 Phosphine 52 *

8000-27-9 Cedarwood oil 34 14

8001-23-8 Safflower oil 46 16

8001-26-1 Prevention 1 (Flaxseed oil) 52 *

@ 8001-26-1 Prevention 1 (Flaxseed oil +

melatonin)

(Primary CASRN is

FLAXSEED+MEL)

52 *
Last Update: 09/18/2015 10:46 Management Status Report Page 69

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

8001-30-7 Corn oil 41 16

8001-35-2 Toxaphene 47 16

8001-79-4 Castor oil 36 16

8001-97-6 Aloe vera gel 39 16

8003-03-0 Aspirin, phenacetin, and caffeine 39 16

8003-22-3 D&C Yellow No. 11 36 16

8003-22-3 D&C Yellow No. 11 41 16

8008-20-6 Navy fuels JP-5 44 16

8013-11-4 Senna (powdered) 37 16

8013-11-4 Senna (powdered) 37 16

8024-37-1 Turmeric, oleoresin (curcumin) 47 16

8057-49-6 Valerian (Valeriana officinalis

L.) root extract

31 3

9000-01-5 Gum Arabic 43 16

9000-30-0 Guar gum 43 16

9000-38-8 Kava kava extract 43 16

9000-40-2 Locust bean gum 44 16

9002-18-0 Agar 38 16

9002-89-5 Polyvinyl alcohol 45 16

9005-65-6 Polysorbate 80 (glycol) 45 16

@ 9007-28-7 Glucosamine Hydrochloride +

Chondroitin Sulfate

(Primary CASRN is

GLUCOSCHONDN)

51 *

9009-54-5 Polyurethane 49 17

9012-76-4 Chitosan 50 *

10026-24-1 Cobalt sulfate heptahydrate 16

10026-24-1 Cobalt sulfate heptahydrate 41 16

10028-15-6 Ozone 45 16

10028-15-6 Ozone 45 16

@ 10028-15-6 Ozone/NNK

(Primary CASRN is OZONNNKCOMB)

45 16

10034-96-5 Manganese sulfate monohydrate 38 16

10034-96-5 Manganese sulfate monohydrate 44 16

10043-35-3 Boric acid 40 16

@ 10060-12-5 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

10096-91-0 Phenolic Benzotriazoles

(2-(2H-Benzotriazol-2-yl)phenol)

32 4

10101-97-0 Nickel sulfate hexahydrate 44 16

10102-18-8 Sodium selenite 37 16

@ 10108-64-2 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

10213-10-2 Sodium Tungstate Dihydrate 33 8

10318-26-0 Dibromodulcitol 48 17

10326-27-9 Barium chloride dihydrate 38 16

10326-27-9 Barium chloride dihydrate 39 16

@ 10599-90-3 Chloraminated water

(Primary CASRN is

CHLORAMINEMX)

40 16

@ 11084-85-8 Chlorinated trisodium phosphate

(Primary CASRN is 56802-99-4)

40 16

@ 11096-82-5 Chemical mixture - drinking water

contaminants

(Primary CASRN is CHEMMIXH2O)

36 16

11097-69-1 Aroclor 1254 39 16

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

12001-28-4 Asbestos, crocidolite 39 16

12001-29-5 Asbestos, chrysotile(IR) 39 16

12001-29-5 Asbestos, chrysotile(IR) 39 16

12001-29-5 Asbestos, chrysotile(IR) 39 16

12001-29-5 Asbestos, chrysotile(IR) +

Dimethyl hydrazine

39 16

12001-29-5 Asbestos, chrysotile(IR) +

Dimethyl hydrazine

39 16

12001-29-5 Asbestos, chrysotile(SR) 39 16

12001-29-5 Asbestos, chrysotile(SR) 39 16

12024-21-4 Gallium oxide 51 *

12035-72-2 Nickel subsulfide 44 16

12172-73-5 Asbestos, amosite 31 4

12172-73-5 Asbestos, amosite 39 16

12172-73-5 Asbestos, amosite 39 16

12172-73-5 Asbestos, amosite + Dimethyl

hydrazine

39 16

13010-47-4 Lomustine 48 17

13171-21-6 Phosphamidon 45 16

@ 13292-46-1 AZT + Rifampin (AIDS Initiative)

(Primary CASRN is AZTRIFAMPIN)

35 16

13311-84-7 Flutamide 51 *

13366-73-9 Photodieldrin 45 16

13410-01-0 Sodium selenate 37 16

13463-67-7 Titanium dioxide 47 16

13552-44-8 4,4'-Methylenedianiline

dihydrochloride

44 16

13674-84-5 Tris(Chloropropyl)phosphate 33 8

13718-26-8 Sodium Metavanadate 32 5

13718-26-8 Sodium Metavanadate 31 2

13765-19-0 Calcium chromate 48 17

13909-09-6 Methyl CCNU 48 17

13983-17-0 Wollastonite calcium silicates 49 17

14047-09-7 3,3',4,4'-Tetrachloroazobenzene 53 *

14047-09-7 3,3',4,4'-Tetrachloroazobenzene 37 16

14047-09-7 3,3',4,4'-Tetrachloroazobenzene 37 16

14047-09-7 3,3',4,4'-Tetrachloroazobenzene 46 16

14371-10-9 trans-Cinnamaldehyde 41 16

14371-10-9 trans-Cinnamaldehyde 51 *

14567-73-8 Tremolite 47 16

14807-96-6 Talc 46 16

14808-60-7 Silica, crystalline - quartz 53 *

14808-60-7 Silica, crystalline - quartz 53 *

14808-60-7 Silica, crystalline - quartz 53 *

15356-70-4 DL-menthol 44 16

15481-70-6 2,6-Toluenediamine

dihydrochloride

(2,6-diaminotoluene

dihydrochloride)

47 16

15481-70-6 Transgenic model evaluation

(2,6-Diaminotoluene 2HCl)

54 *

15481-70-6 Transgenic model evaluation

(2,6-Diaminotoluene 2HCl)

54 *

15625-89-5 Trimethylolpropane triacrylate 35 16

15625-89-5 Trimethylolpropane triacrylate 35 16

15625-89-5 Trimethylolpropane triacrylate 47 16

15805-73-9 Transgenic LEP (Vinyl carbamate) 53 *
Last Update: 09/18/2015 10:46 Management Status Report Page 70

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

@ 15972-60-8 Pesticide/fertilizer

contamination--mixture 3

(Primary CASRN is

PESTFERTMIX3)

37 16

16071-86-6 C.I. Direct Brown 95 36 16

@ 16561-29-8 Arsenic antioxidant mixture

(Primary CASRN is

ANTIOXCOMBO2)

50 *

@ 16561-29-8 Arsenic antioxidant mixture

(Primary CASRN is

ANTIOXCOMBO2)

50 *

@ 16561-29-8 Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

(Primary CASRN is INIT/PROM)

43 16

@ 16561-29-8 Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

(Primary CASRN is INIT/PROM)

43 16

@ 16561-29-8 Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

(Primary CASRN is INIT/PROM)

43 16

16561-29-8 Tetradecanoyl phorbol acetate

(TPA)

53 *

16561-29-8 Transgenic LECM (Tetradecanoyl

phorbol acetate (TPA))

53 *

17026-81-2 3-Amino-4-ethoxyacetanilide 39 16

17924-92-4 Zearalenone 48 16

18107-18-1 Trimethylsilyldiazomethane (TMSD) 32 4

18662-53-8 Nitrilotriacetic acid trisodium

monohydrate

44 16

18662-53-8 Nitrilotriacetic acid trisodium

monohydrate

44 16

18883-66-4 Streptozotocin 49 17

19010-66-3 Lead dimethyldithiocarbamate 43 16

20265-96-7 p-Chloroaniline hydrochloride 40 16

20265-97-8 p-Anisidine hydrochloride 39 16

20265-97-8 Transgenic LEP (p-Anisidine

hydrochloride)

53 *

20265-97-8 Transgenic model evaluation

(p-Anisidine HCl)

53 *

20325-40-0 3,3'-Dimethoxybenzidine

dihydrochloride

42 16

20830-81-3 Daunomycin 48 17

20941-65-5 Ethyl tellurac 42 16

@ 21087-64-9 Pesticide/fertilizer

contamination--mixture 3

(Primary CASRN is

PESTFERTMIX3)

37 16

21232-47-3 3,3',4,4'-Tetrachloroazoxybenzene 37 16

@ 21416-67-1 ICRF-159

(Primary CASRN is 21416-87-5)

43 16

21416-87-5 ICRF-159 43 16

@ 21725-46-2 Pesticide/fertilizer

contamination--mixture 3

(Primary CASRN is

PESTFERTMIX3)

37 16

21739-91-3 Cytembena 41 16

21850-44-2 Tetrabromobisphenol

A-bis(2,3-dibromopropyl ether)

34 12

22398-80-7 Indium phosphide 43 16

22839-47-0 Transgenic model evaluation II

(Aspartame)

35 16

22839-47-0 Transgenic model evaluation II

(Aspartame)

35 16

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

22966-79-6 Estradiol mustard 42 16

23246-96-0 Riddelliine 37 16

23246-96-0 Riddelliine 46 16

24072-75-1 5,6-Dichloro-2-benzothiazolamine 51 *

24382-04-5 Malonaldehyde, sodium salt 44 16

25013-15-4 Vinyl toluene 47 16

25152-84-5 2,4-Decadienal 51 *

25152-84-5 2,4-Decadienal 36 16

25265-71-8 Dipropylene glycol 38 16

25265-71-8 Dipropylene glycol 42 16

25812-30-0 Peroxisome project (Gemfibrozil) 52 *

25973-55-1 Phenolic Benzotriazoles (Phenol,

2-(2H-benzotriazol-2-yl)-4,6-

bis(1,1-dimethylpropyl)-)

32 4

26471-62-5 2,4- & 2,6-Toluene diisocyanate 47 16

26628-22-8 Sodium azide 46 16

26780-96-1 1,2-Dihydro-2,2,4-

trimethylquinoline (polymer)

51 *

27774-13-6 Vanadyl sulfate 32 5

27774-13-6 Vanadyl sulfate 31 3

27882-76-4 Chromium picolinate monohydrate 41 16

28300-74-5 Antimony potassium tartrate 16

28407-37-6 C.I. Direct Blue 218 38 16

28407-37-6 C.I. Direct Blue 218 41 16

29761-21-5 Isodecyl Diphenyl Phosphate 51 *

30516-87-1 3'-Azido-3'-deoxythymidine (AIDS) 39 16

30516-87-1 3'-Azido-3'-deoxythymidine (AIDS) 39 16

30516-87-1 3'-Azido-3'-deoxythymidine (AIDS) 39 16

30516-87-1 3'-Azido-3'-deoxythymidine (AIDS) 39 16

30516-87-1 3'-Azido-3'-deoxythymidine (AIDS) 39 16

30516-87-1 3'-Azido-3'-deoxythymidine (AIDS) 39 16

30516-87-1 3'-Azido-3'-deoxythymidine (AIDS) 39 16

30516-87-1 3'-Azido-3'-deoxythymidine (AIDS) 39 16

30516-87-1 3'-Azido-3'-deoxythymidine (AIDS) 39 16

30516-87-1 3'-Azido-3'-deoxythymidine (AIDS) 39 16

30516-87-1 3'-Azido-3'-deoxythymidine (AIDS) 39 16

@ 30516-87-1 3'-Azido-3'-deoxythymidine and

2',3'-Dideoxycytidine

(Primary CASRN is AZTDDCCOMB)

50 *

@ 30516-87-1 3'-Azido-3'-deoxythymidine

and 2',3'-Dideoxyinosine (AIDS

initiative)

(Primary CASRN is AZTDDICOMB)

50 *

@ 30516-87-1 AZT+3TC+NVP combination

(Primary CASRN is AZT3TCCOMBO)

39 16

@ 30516-87-1 AZT/Drug Combinations

Transplacental/Neonatal Study

(Primary CASRN is

AIDSDRUGSNEO)

33 8

@ 30516-87-1 AZT + Isoniazid (AIDS Initiative)

(Primary CASRN is

AZTISONIAZID)

35 16

@ 30516-87-1 AZT + Methadone HCl (AIDS)

(Primary CASRN is AZTMETHCOMB)

50 *

@ 30516-87-1 AZT + Nitazoxanide (AIDS

Initiative)

(Primary CASRN is AZT+NITAZOX)

50 *
Last Update: 09/18/2015 10:46 Management Status Report Page 71

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

@ 30516-87-1 AZT + Pyrazinamide combination

(AIDS Initiative)

(Primary CASRN is AZTZINAMIDE)

35 16

@ 30516-87-1 AZT + Rifampin (AIDS Initiative)

(Primary CASRN is AZTRIFAMPIN)

35 16

@ 30516-87-1 AZT + TMP/SMX (mixture)

combination

(Primary CASRN is AZTTMPSMX)

50 *

@ 30516-87-1 AZT + TMP/SMX (mixture)

combination

(Primary CASRN is AZTTMPSMX)

50 *

30516-87-1 AZT transplacental carcinogenesis

study

39 16

@ 30516-87-1 Interferon AD + 3'-azido-3'-

deoxythymidine (AIDS Initiative)

(Primary CASRN is INTAZTCOMB)

43 16

31508-00-6 Toxic equivalency factor

evaluation (PCB 118)

46 16

@ 31508-00-6 Toxic equivalency factor

evaluation (PCB Mixture; PCB 126/

PCB 118)

(Primary CASRN is TEFPCBMIX)

46 16

@ 32534-81-9 BDE Toxicogenomics Study (TGMX)

(Primary CASRN is

TGMXBDECLASS)

31 2

32534-81-9 Pentabromodiphenyl Oxide

(Technical) (DE 71)

34 13

32534-81-9 Pentabromodiphenyl Oxide

(Technical) (DE 71)

31 3

32534-81-9 Pentabromodiphenyl Oxide

(Technical) (DE 71)

31 2

32534-81-9 Pentabromodiphenyl Oxide

(Technical) (DE 71)

32 5

32534-81-9 Pentabromodiphenyl Oxide

(Technical) (DE 71)

32 4

33229-34-4 HC Blue 2 43 16

33286-22-5 QT drugs (diltiazem

hydrochloride)

52 *

33857-26-0 2,7-Dichlorodibenzo-p-dioxin 41 16

34256-82-1 Acetochlor 49 *

@ 34885-03-5 Crude MCHM

(Primary CASRN is CRUDEMCHM)

32 5

34885-03-5 4-Methylcyclohexanemethanol 32 5

@ 35065-27-1 Toxic equivalency factor

evaluation (Binary mixture; PCB

126/PCB 153)

(Primary CASRN is

TEFBINARYMIX)

46 16

35065-27-1 Toxic equivalency factor

evaluation (PCB 153- 2,2'-

4,4',5,5'-hexachlorobiphenyl)

47 16

35691-65-7 1,2-Dibromo-2,4-dicyanobutane 51 *

35691-65-7 1,2-Dibromo-2,4-dicyanobutane 51 *

35691-65-7 1,2-Dibromo-2,4-dicyanobutane 36 16

35691-65-7 1,2-Dibromo-2,4-dicyanobutane 41 16

37319-17-8 Elmiron (sodium

pentosanpolysulfate)

42 16

37319-17-8 Elmiron (sodium

pentosanpolysulfate)

38 16

39156-41-7 2,4-Diaminoanisole sulfate 41 16

39300-88-4 Tara gum 46 16

41372-08-1 Methyldopa sesquihydrate 44 16

50471-44-8 Vinclozolin 55 *

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

50647-08-0 Ginseng 43 16

50679-08-8 QT drugs (terfenadine) 53 *

50892-23-4 Peroxisome project (WY-14643) 37 16

50892-23-4 Transgenic model evaluation

(WY-14643)

54 *

50892-23-4 Transgenic model evaluation

(WY-14643)

54 *

50892-23-4 Wyeth 14,643 (WY) 33 6

50892-23-4 Wyeth 14,643 (WY) 55 *

@ 51181-40-9 Crude MCHM

(Primary CASRN is CRUDEMCHM)

32 5

@ 51218-45-2 Pesticide/fertilizer

contamination--mixture 3

(Primary CASRN is

PESTFERTMIX3)

37 16

51264-14-3 Amsacrine 48 17

51481-10-8 Deoxynivalenol 31 2

51730-94-0 Dipropylene glycol phenyl ether 32 4

54150-69-5 2,4-Dimethoxyaniline

hydrochloride

42 16

54464-57-2 Ethanone, 1-(1,2,3,4,5,6,7,8-

Octahydro-2,3,8,8-Tetramethyl-2-

Naphthalenyl)- (Iso-E Super®;

OTNE)

34 14

55566-30-8 Tetrakis(hydroxymethyl)phosphonium

sulfate

46 16

55589-62-3 Transgenic Model Evaluation II

(Acesulfame Potassium)

35 16

@ 55981-09-4 AZT + Nitazoxanide (AIDS

Initiative)

(Primary CASRN is AZT+NITAZOX)

50 *

56802-99-4 Chlorinated trisodium phosphate 40 16

56803-37-3 tert-Butylphenyl Diphenyl

Phosphate

50 *

56803-37-3 tert-Butylphenyl Diphenyl

Phosphate

31 2

57018-52-7 Propylene glycol mono-t-butyl

ether

45 16

57117-31-4 Toxic equivalency

factor evaluation (PECDF

(Pentachlorodibenzofuran))

46 16

@ 57117-31-4 TEF transgenics (PCB 126 / PECDF

mixture)

(Primary CASRN is

TEFTGMIXTURE)

53 *

57117-31-4 TEF transgenics (PECDF) 53 *

@ 57117-31-4 Toxic equivalency factor

evaluation (Dioxin mixture)

(Primary CASRN is

TEFDIOXINMIX)

47 16

57465-28-8 3,3,4,4,5-Pentachlorobiphenyl

(PCB 126)

32 4

@ 57465-28-8 Toxic equivalency factor

evaluation (Binary mixture; PCB

126/PCB 153)

(Primary CASRN is

TEFBINARYMIX)

46 16

@ 57465-28-8 Toxic equivalency factor

evaluation (PCB Mixture; PCB 126/

PCB 118)

(Primary CASRN is TEFPCBMIX)

46 16

57465-28-8 TEF transgenics (PCB 126) 53 *
Last Update: 09/18/2015 10:46 Management Status Report Page 72

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

@ 57465-28-8 TEF transgenics (PCB 126 / PECDF

mixture)

(Primary CASRN is

TEFTGMIXTURE)

53 *

@ 57465-28-8 Toxic equivalency factor

evaluation (Dioxin mixture)

(Primary CASRN is

TEFDIOXINMIX)

47 16

57465-28-8 Toxic equivalency factor

evaluation ((PCB 126)

3,3',4,4',5-pentachlorobiphenyl)

47 16

57653-85-7 1,2,3,6,7,8-Hexachlorodibenzo-pdioxin43 16

57653-85-7 1,2,3,6,7,8-Hexachlorodibenzo-pdioxin43 16

59820-43-8 HC Yellow 4 43 16

59865-13-3 Transgenic LEP (Cyclosporin A) 53 *

59865-13-3 Transgenic model evaluation

(Cyclosporin A)

54 *

59865-13-3 Transgenic model evaluation

(Cyclosporin A)

54 *

@ 60348-60-9 BDE Toxicogenomics Study (TGMX)

(Primary CASRN is

TGMXBDECLASS)

31 2

60348-60-9 2,2',4,4',5-Pentabromodiphenyl

Ether

31 2

61702-44-1 2-Chloro-p-phenylenediamine

sulfate

40 16

@ 63449-39-8 Chlorinated paraffins: C12, 60%

chlorine

(Primary CASRN is 108171-26-2)

40 16

@ 63449-39-8 Chlorinated paraffins: C23, 43%

chlorine

(Primary CASRN is 108171-27-3)

40 16

@ 64091-91-4 Ozone/NNK

(Primary CASRN is OZONNNKCOMB)

45 16

64742-88-7 Stoddard solvent (type lIC) 46 16

65039-09-0 Ionic Liquid:

1-Ethyl-3-methylimidazolium

Chloride

32 5

@ 65039-09-0 Ionic liquid Toxicity

(Primary CASRN is

IONICLIQUIDS)

51 *

65646-68-6 Retinoid project 2

(4-(Hydroxyphenyl)retinamide)

53 *

@ 65646-68-6 Retinoid project 1

(Primary CASRN is RETINOID1)

53 *

65646-68-6 Retinoid project 4

(4-(Hydroxyphenyl)retinamide)

53 *

65646-68-6 Retinoid project 5

(4-(Hydroxyphenyl)retinamide)

53 *

65646-68-6 Retinoid project 6 (4-HPR) 53 *

65666-07-1 Prevention 2 (Silymarin) 52 *

@ 65666-07-1 Prevention 2 (Silymarin +

melatonin)

(Primary CASRN is

SILYMARN+MEL)

52 *

67774-32-7 Polybrominated biphenyl mixture

(Firemaster FF-1)

45 16

67774-32-7 Polybrominated biphenyl mixture

(Firemaster FF-1)

45 16

68359-37-5 Cyfluthrin 51 *

68603-42-9 Coconut oil acid diethanolamine

condensate

41 16

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

68603-42-9 Transgenic LECM (Coconut oil acid

diethanolamine condensate)

53 *

68603-42-9 Transgenic LECM (Coconut oil acid

diethanolamine condensate)

53 *

@ 68631-49-2 BDE Toxicogenomics Study (TGMX)

(Primary CASRN is

TGMXBDECLASS)

31 2

68631-49-2 2,2',4,4',5,5'-Hexabromodiphenyl

ether (PBDE 153)

31 2

68937-41-7 Isopropylated Phenol Phosphate 32 5

68937-41-7 Isopropylated Phenol Phosphate 51 *

@ 69655-05-6 3'-Azido-3'-deoxythymidine

and 2',3'-Dideoxyinosine (AIDS

initiative)

(Primary CASRN is AZTDDICOMB)

50 *

70321-86-7 Phenolic Benzotriazoles (Phenol,

2-(2H-benzotriazol-2-yl)-4,6-

bis(1-methyl-1-phenylethyl)-)

32 4

71133-14-7 Water disinfection byproducts

(Bromodichloroacetic Acid)

55 *

71133-14-7 Water disinfection byproducts

(Bromodichloroacetic Acid)

34 14

74764-40-2 QT drugs (bepridil hydrochloride) 52 *

75330-75-5 QT drugs (Lovastatin) 53 *

76231-76-0 alpha/beta Thujone mixture 37 16

76231-76-0 alpha/beta Thujone mixture 47 16

76543-88-9 Interferon A (AIDS Initiative) 43 16

77439-76-0 3-Chloro-4-(dichloromethyl)-5-

hydroxy-2(5H)-furanone(MX)

50 *

79794-75-5 QT drugs (Loratadine) 53 *

79917-90-1 Ionic Liquid:

1-Butyl-3-methylimidazolium

Chloride

32 5

@ 79917-90-1 Ionic liquid Toxicity

(Primary CASRN is

IONICLIQUIDS)

51 *

84268-23-5 Phenolic Benzotriazoles (3-(2HBenzotriazol-2-yl)-5-(1,1-

dimethylethyl)-4-

hydroxybenzenepropanoic acid,

octyl ester)

32 4

84604-20-6 Milk thistle extract 44 16

84776-26-1 Black Cohosh 50 *

84776-26-1 Black Cohosh 33 8

84776-26-1 Black Cohosh 50 *

84776-26-1 Black Cohosh 50 *

85509-19-9 Flusilazole 51 *

90045-23-1 Garcinia Cambogia Extract 32 5

90045-36-6 Ginkgo biloba extract 43 16

90045-36-6 Ginkgo biloba extract 31 2

96180-79-9 Microcystin-LA (TGMX) 52 *

@ 96180-79-9 Microcystin mixture (TGMX)

(Primary CASRN is

MICROCYSTNMX)

52 *

@ 98955-27-2 Crude MCHM

(Primary CASRN is CRUDEMCHM)

32 5

99685-96-8 Nanoscale Material (Fullerene C60

18 microns)

31 3

99685-96-8 Nanoscale material (Fullerene-C60

1 micron)

34 12

99685-96-8 Nanoscale Material (Fullerene C60

200 nanometers)

31 3
Last Update: 09/18/2015 10:46 Management Status Report Page 73

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

99685-96-8 Nanoscale material (Fullerene-C60

50 nanometers)

34 12

101043-37-2 Microcystin-LR (TGMX) 52 *

@ 101043-37-2 Microcystin mixture (TGMX)

(Primary CASRN is

MICROCYSTNMX)

52 *

108171-26-2 Chlorinated paraffins: C12, 60%

chlorine

40 16

108171-27-3 Chlorinated paraffins: C23, 43%

chlorine

40 16

113136-77-9 Cyclanilide 51 *

116355-83-0 Fumonisin B1 38 16

116355-83-0 Fumonisin B1 43 16

119168-77-3 Tebufenpyrad 53 *

121552-61-2 Cyprodinil 51 *

125533-88-2 Retinoid project 6 (Arotinoid) 53 *

125533-88-2 Retinoid project 3 (Arotinoid) 53 *

125533-88-2 Retinoid project 5 (Arotinoid) 53 *

@ 129618-40-2 AZT+3TC+NVP combination

(Primary CASRN is AZT3TCCOMBO)

39 16

@ 129618-40-2 AZT/Drug Combinations

Transplacental/Neonatal Study

(Primary CASRN is

AIDSDRUGSNEO)

33 8

@ 134678-17-4 AZT+3TC+NVP combination

(Primary CASRN is AZT3TCCOMBO)

39 16

@ 134678-17-4 AZT/Drug Combinations

Transplacental/Neonatal Study

(Primary CASRN is

AIDSDRUGSNEO)

33 8

@ 154598-52-4 AZT/Drug Combinations

Transplacental/Neonatal Study

(Primary CASRN is

AIDSDRUGSNEO)

33 8

@ 159989-65-8 AZT/Drug Combinations

Transplacental/Neonatal Study

(Primary CASRN is

AIDSDRUGSNEO)

33 8

173584-44-6 Indoxacarb 51 *

299184-76-2 Dong quai Angelica sinensis root

extract

31 2

479500-35-1 Ionic Liquid:

1-Butyl-1-methylpyrrolidinium

Chloride

32 5

@ 479500-35-1 Ionic liquid Toxicity

(Primary CASRN is

IONICLIQUIDS)

51 *

@ 103-90-2 Rat feed study (TGMX rat liver

evaluation)

(Primary CASRN is

TGMXRALVFEED)

53 *

@ 103426-96-6 PCN 66/67 comparison study

(Primary CASRN is

PCNCOMPARISN)

34 14

@ 103426-97-7 PCN 66/67 comparison study

(Primary CASRN is

PCNCOMPARISN)

34 14

@ 1162-65-8 Rat feed study (TGMX rat liver

evaluation)

(Primary CASRN is

TGMXRALVFEED)

53 *

@ 1746-01-6 PCN 66/67 comparison study

(Primary CASRN is

PCNCOMPARISN)

34 14

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

@ 50-81-7 Rat feed study (TGMX rat liver

evaluation)

(Primary CASRN is

TGMXRALVFEED)

53 *

@ 69-72-7 alpha/beta Hydroxy acids

(glycolic acid, salicylic acid)

(Primary CASRN is

HYDROXGLYSAL)

39 16

@ 73-22-3 Rat feed study (TGMX rat liver

evaluation)

(Primary CASRN is

TGMXRALVFEED)

53 *

@ 79-14-1 alpha/beta Hydroxy acids

(glycolic acid, salicylic acid)

(Primary CASRN is

HYDROXGLYSAL)

39 16

@ 81-49-2 Rat feed study (TGMX rat liver

evaluation)

(Primary CASRN is

TGMXRALVFEED)

53 *

AAV2HAQP1 Serotype 2 Adeno-associated Viral

Vector hAQP1 (rAAV2hAQP1)

34 12

AAVIRAAVHEPO Serotype 2 Adeno-associated Viral

Vector rAAV2rapahEpo

34 14

AAVIRVECEPO Adeno-associated viral vector

(hEPO)

50 *

ADNVIRVECAQP Adenoviral Vector (AdhAQP1) 50 *

ADNVIRVECHGH Adenoviral vector (hGH) 50 *

AIDSDRUGSNEO AZT/Drug Combinations

Transplacental/Neonatal Study

33 8

AIDSTHERAPEU AZT/Drug Combinations

Transplacental Carcinogenesis

Study

39 16

ALOEPHOTOTOX Aloe phototoxicity studies 39 16

ALOEVFILTER Aloe vera charcoal filtered whole

leaf extract

39 16

ALOEVLEAFEXT Aloe vera whole leaf extract

(native)

39 16

ALOEVLEAFEXT Aloe vera whole leaf extract

(native)

39 16

AMINOPYRCOMP Comparison study of

Aminopyridines/Troponin levels

50 *

ANTIOXCOMBO2 Arsenic antioxidant mixture 50 *

ANTIOXCOMBO2 Arsenic antioxidant mixture 50 *

@ ANTIOXMODEL Antioxidant model (TRAMP) -

Epigallocatechin gallate

(Primary CASRN is 989-51-5)

50 *

ASPERGILLUS Aspergillus fumigatus mold 31 3

ASPERGILLUSV Aspergillus versicolor mold 31 4

AZT+NITAZOX AZT + Nitazoxanide (AIDS

Initiative)

50 *

AZT3TCCOMBO AZT+3TC+NVP combination 39 16

AZTDDCCOMB 3'-Azido-3'-deoxythymidine and

2',3'-Dideoxycytidine

50 *

AZTDDICOMB 3'-Azido-3'-deoxythymidine

and 2',3'-Dideoxyinosine (AIDS

initiative)

50 *

AZTISONIAZID AZT + Isoniazid (AIDS Initiative) 35 16

AZTMETHCOMB AZT + Methadone HCl (AIDS) 50 *

AZTRIFAMPIN AZT + Rifampin (AIDS Initiative) 35 16

AZTTMPSMX AZT + TMP/SMX (mixture)

combination

50 *

AZTTMPSMX AZT + TMP/SMX (mixture)

combination

50 *
Last Update: 09/18/2015 10:46 Management Status Report Page 74

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

AZTZINAMIDE AZT + Pyrazinamide combination

(AIDS Initiative)

35 16

@ BDEMIXTURE BDE Toxicogenomics Study (TGMX)

(Primary CASRN is

TGMXBDECLASS)

31 2

@ BENZOTRIAZOLESPhenolic Benzotriazoles (2-

(2H-Benzotriazol-2-yl)-4-tertbutylphenol)

(Primary CASRN is 3147-76-0)

31 4

@ BENZOTRIAZOLESPhenolic Benzotriazoles

(Drometrizole)

(Primary CASRN is 2440-22-4)

32 4

@ BENZOTRIAZOLESPhenolic Benzotriazoles (3-

(2H-Benzotriazol-2-yl)-

5-(1,1-dimethylethyl)-4-

hydroxybenzenepropanoic acid,

octyl ester)

(Primary CASRN is 84268-23-5)

32 4

@ BENZOTRIAZOLESPhenolic Benzotriazoles

(Octrizole)

(Primary CASRN is 3147-75-9)

32 4

@ BENZOTRIAZOLESPhenolic Benzotriazoles (2-(2HBenzotriazol-2-yl)phenol)

(Primary CASRN is 10096-91-0)

32 4

@ BENZOTRIAZOLESPhenolic Benzotriazoles (Phenol,

2-(2H-benzotriazol-2-yl)-4,6-

bis(1,1-dimethylpropyl)-)

(Primary CASRN is 25973-55-1)

32 4

@ BENZOTRIAZOLESPhenolic Benzotriazoles (Phenol,

2-(2H-benzotriazol-2-yl)-4,6-

bis(1-methyl-1-phenylethyl)-)

(Primary CASRN is 70321-86-7)

32 4

@ BENZOTRIAZOLESPhenolic Benzotriazoles (2-(5-

Chloro-2Hbenzotriazol-2-yl)-

4,6bis(1,1 dimethylethyl)phenol)

(Primary CASRN is 3864-99-1)

32 4

@ BENZOTRIAZOLESPhenolic Benzotriazoles

(Bumetrizole)

(Primary CASRN is 3896-11-5)

32 4

BLASTINGSAND Abrasive Blasting Agents:

Blasting Sand

34 14

CARDIOGENEVL Cardio Transmitter Gene

Evaluation

50 *

CELLPRADCDMA Cell Phone Radiation: CDMA 33 8

CELLPRADGSM Cell Phone Radiation: GSM 33 8

CELLULOSEINS Cellulose insulation 36 16

CHEMMIXH2O Chemical mixture - drinking water

contaminants

36 16

CHLORAMINEMX Chloraminated water 40 16

CHLORWATERMX Chlorinated water 40 16

CIMSTAR3800 Metal Working Fluids: CIMSTAR

3800

34 14

COALSLAG Abrasive blasting agents (coal

slag)

49 *

CRUDEMCHM Crude MCHM 32 5

CRUSHEDGLASS Abrasive blasting agents (crushed

glass)

49 *

DIESELFUEL Diesel fuel marine 42 16

DIET2000 NTP-2000 diet 52 *

DIET88+EGMBE NTP-88 diet study (EGMBE) 52 *

DIET88+EGMEE NTP-88 diet study (EGMEE) 52 *

DIET88+EGMME NTP-88 diet study (EGMME) 52 *

DIET88+MNITR NTP-88 diet study

(m-Nitrotoluene)

52 *

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

DIET88+ONITR NTP-88 diet study

(o-Nitrotoluene)

52 *

DIET88+PNITR NTP-88 diet study

(p-Nitrotoluene)

52 *

DIET90 NTP 90 diet study 49 17

DIET9192 NTP 91/92 diet study 49 17

DIETEVAL Diet Evaluation Study 51 *

DIETH/DIMETH Diethyl phthalate/dimethyl

phthalate

42 16

ECOLI_LPS Lipopolysaccharides from

Escherichia coli

51 *

@ EFSSINVECTOR Insertional Mutagenesis -

Definitive Vector Study

(Primary CASRN is INSERTMUT3)

33 8

@ EFSSINVECTOR Insertional Mutagenesis -

Definitive Vector Study

(Primary CASRN is INSERTMUT3)

32 4

ELECTROMAG Magnetic fields (EMF) 44 16

ELECTROMAG Magnetic fields (EMF) 51 *

ELECTROMAG Magnetic fields (EMF) 37 16

@ ELECTROMAG Magnetic fields + DMBA initiation

promotion

(Primary CASRN is EMF+DMBA)

37 16

EMF+DMBA Magnetic fields + DMBA initiation

promotion

37 16

@ EMTDP-33 Diesel fuel marine

(Primary CASRN is DIESELFUEL)

42 16

@ EMTDP-71 Chlorinated paraffins: C23, 43%

chlorine

(Primary CASRN is 108171-27-3)

40 16

EMTDP-74 Selsun 46 16

EMTDP-75 Black newsprint ink 35 16

EMTDP-76 3-Methyl-6-methoxy-2-aminobenzothiazolium chloride52 *

EMTDP-76 3-Methyl-6-methoxy-2-aminobenzothiazolium chloride52 *

@ EMTDP-86 3'-Azido-3'-deoxythymidine and

2',3'-Dideoxycytidine

(Primary CASRN is AZTDDCCOMB)

50 *

@ EMTDP-92 Pesticide/fertilizer

contamination--mixture 2

(Primary CASRN is

PESTFERTMIX2)

37 16

@ EMTDP-93 Pesticide/fertilizer

contamination--mixture 3

(Primary CASRN is

PESTFERTMIX3)

37 16

@ EMTDP-99 Urethane + ethanol (combination)

(Primary CASRN is URETHCOMB)

37 16

@ EMTDP-99 Urethane + ethanol (combination)

(Primary CASRN is URETHCOMB)

47 16

EPHEDCOMBO Ephedrine + caffeine combination 51 *

EPHEDCOMBO Ephedrine + caffeine combination 51 *

FEEDRESTRICT Feed restriction studies 42 16

FLAXSEED+MEL Prevention 1 (Flaxseed oil +

melatonin)

52 *

GARNET Abrasive blasting agents (garnet) 49 *

GLUCOSCHONDN Glucosamine Hydrochloride +

Chondroitin Sulfate

51 *

GLYCINEBENZA Benzyl acetate + glycine

combination study

50 *

GOLDENSEALRT Goldenseal root powder 36 16
Last Update: 09/18/2015 10:46 Management Status Report Page 75

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

GOLDENSEALRT Goldenseal root powder 43 16

GREENTEAEXTR Green Tea Extract 34 14

GUMGUGGULEXT Gum Guggul Extract 51 *

HEMATITESPEC Abrasive Blasting Agents:

Specular Hematite

34 14

HYDROXGLYSAL alpha/beta Hydroxy acids

(glycolic acid, salicylic acid)

39 16

INIT/PROM Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

43 16

INIT/PROM Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

43 16

INIT/PROM Init/prom comparative mouse study

(DMBA/TPA/BPO/MNNG)

43 16

INSERTMUT Insertional mutagenesis (LTR/SIN

vectors)

51 *

INSERTMUT2 Insertional mutagenesis II (SIN

vector)

51 *

INSERTMUT3 Insertional Mutagenesis -

Definitive Vector Study

33 8

INSERTMUT3 Insertional Mutagenesis -

Definitive Vector Study

32 4

INSERTMUTRAD Insertional mutagenesis

(Radiation Levels)

51 *

INTAZTCOMB Interferon AD +

3'-azido-3'-deoxythymidine (AIDS

Initiative)

43 16

INTDDCCOMB Interferon AD + ddC (AIDS

Initiative)

51 *

INTERFERONAD Interferon AD (AIDS Initiative) 43 16

@ INTERFERONAD Interferon AD + 3'-azido-3'-

deoxythymidine (AIDS Initiative)

(Primary CASRN is INTAZTCOMB)

43 16

@ INTERFERONAD Interferon AD + ddC (AIDS

Initiative)

(Primary CASRN is INTDDCCOMB)

51 *

IONICLIQUIDS Ionic liquid Toxicity 51 *

ISOFLAVCONCN Prevention 6 (isoflavone

concentrate)

52 *

ISOFLAVSOYPT Prevention 6 (low isoflavone soy

protein powder)

52 *

LEADORES Lead ores 51 *

L-MWNT-1020 1020 Long Multiwalled Carbon

Nanotube

34 13

L-MWNT-1020 1020 Long Multiwalled Carbon

Nanotube

32 4

@ LTRVECTOR Insertional Mutagenesis -

Definitive Vector Study

(Primary CASRN is INSERTMUT3)

33 8

@ LTRVECTOR Insertional Mutagenesis -

Definitive Vector Study

(Primary CASRN is INSERTMUT3)

32 4

MEL+CURCUMIN Prevention 4 (Melatonin +

curcumin)

52 *

MEL+INDOLCAR Prevention 4 (Melatonin +

indole-3-carbinol)

52 *

MELCYANCOMB Melamine + Cyanuric Acid

combination

32 5

MELCYANCOMB Melamine + Cyanuric Acid

combination

51 *

MICROCYSTNMX Microcystin mixture (TGMX) 52 *

MOUSEAGE Mouse ageing study 48 17

MOUSEPHENO1 Aging Cohort Study: 129/SvlmJ

mouse

33 8

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

MOUSEPHENO10 Aging Cohort Study: NZO/HiLtJ

mouse

33 8

MOUSEPHENO2 Aging Cohort Study: A/J mouse 33 8

MOUSEPHENO3 Aging Cohort Study: C3H/HeJ mouse 33 8

MOUSEPHENO4 Aging Cohort Study: C57/BL/6J

mouse

33 8

MOUSEPHENO5 Aging Cohort Study: CAST/EiJ

mouse

33 8

MOUSEPHENO6 Aging Cohort Study: B6C3F1J mouse 33 8

MOUSEPHENO7 Aging Cohort Study: NOD.

B10Sn-H2(b)/J

33 8

MOUSEPHENO8 Aging Cohort Study: PWK/PhJ mouse 33 8

MOUSEPHENO9 Aging Cohort Study: WSB/EIJ mouse 33 8

@ NAOSPINEXTR Arsenic antioxidant mixture

(Primary CASRN is

ANTIOXCOMBO2)

50 *

@ NAOSPINEXTR Arsenic antioxidant mixture

(Primary CASRN is

ANTIOXCOMBO2)

50 *

NAOSPINEXTR Antioxidant model (TRAMP) - NAO

(spinach extract)

50 *

NCTSTANDARD NCT/DERT standardization

experiment (APAP & AMAP)

52 *

@ NTPMOCKVEC Insertional Mutagenesis -

Definitive Vector Study

(Primary CASRN is INSERTMUT3)

33 8

@ NTPMOCKVEC Insertional Mutagenesis -

Definitive Vector Study

(Primary CASRN is INSERTMUT3)

32 4

OZONNNKCOMB Ozone/NNK 45 16

PBCONTAMSOIL Lead contaminated soil 51 *

PCNCOMPARISN PCN 66/67 comparison study 34 14

PESTFERTMIX2 Pesticide/fertilizer

contamination--mixture 2

37 16

PESTFERTMIX3 Pesticide/fertilizer

contamination--mixture 3

37 16

PREGRATECOMP Pregnancy Rate Comparison Study 52 *

PREVENTION10 Prevention 10 (Soy isoflavone

concentrate)

52 *

PREVENTION7 Prevention 7 (feed controls) 52 *

@ PSINVECTOR Insertional Mutagenesis -

Definitive Vector Study

(Primary CASRN is INSERTMUT3)

33 8

@ PSINVECTOR Insertional Mutagenesis -

Definitive Vector Study

(Primary CASRN is INSERTMUT3)

32 4

QUANTUMDOTS Nanoscale material (Quantum dots) 52 *

RAV5SCTLA4IG Serotype 5 Adeno-associated Viral

Vector (rAAV5SCTLA4:Ig)

34 14

RETINOID1 Retinoid project 1 53 *

RETROVIRVECT Retroviral vectors 53 *

RETROVIRVECT Retroviral vectors 53 *

RETROVIRVECT Retroviral vectors 53 *

RETROVIRVECT Retroviral vectors 53 *

SANTRIMER2 Styrene-acrylonitrile trimer 46 16

SILYMARN+MEL Prevention 2 (Silymarin +

melatonin)

52 *

@ SINVECTOR Insertional Mutagenesis -

Definitive Vector Study

(Primary CASRN is INSERTMUT3)

33 8
Last Update: 09/18/2015 10:46 Management Status Report Page 76

@ Denotes multiple CASRNs for study -- see following line for primary CASRN

* See Appendix, Short-Term Studies for Which Toxicity Technical Reports Were Not Prepared

Index of Chemicals by Chemical Abstracts Service

Registry Number (CASRN) with Reference Location

CASRN CHEMICAL NAME PAGE REF

@ SINVECTOR Insertional Mutagenesis -

Definitive Vector Study

(Primary CASRN is INSERTMUT3)

32 4

STEELWELDFUM Welding fumes 55 *

SYNTILO1023 Metal working fluids (Syntilo

1023)

51 *

TEFBINARYMIX Toxic equivalency factor

evaluation (Binary mixture; PCB

126/PCB 153)

46 16

TEFDIOXINMIX Toxic equivalency factor

evaluation (Dioxin mixture)

47 16

TEFPCBMIX Toxic equivalency factor

evaluation (PCB Mixture; PCB

126/PCB 118)

46 16

TEFTGMIXTURE TEF transgenics (PCB 126 / PECDF

mixture)

53 *

@ TGMODELEVAL Transgenic Model Evaluation II

(Acesulfame Potassium)

(Primary CASRN is 55589-62-3)

35 16

TGMXBDECLASS BDE Toxicogenomics Study (TGMX) 31 2

TGMXFLAVCLAS Toxicogenomics study of

allylbenzene & propenylbenzene

class flavor constituents (TGMX)

53 *

TGMXRALVFEED Rat feed study (TGMX rat liver

evaluation)

53 *

@ THUJONEMIXAB alpha/beta Thujone mixture

(Primary CASRN is 76231-76-0)

37 16

@ THUJONEMIXAB alpha/beta Thujone mixture

(Primary CASRN is 76231-76-0)

47 16

@ TMPSMXMIXNTP AZT + TMP/SMX (mixture)

combination

(Primary CASRN is AZTTMPSMX)

50 *

@ TMPSMXMIXNTP AZT + TMP/SMX (mixture)

combination

(Primary CASRN is AZTTMPSMX)

50 *

TRIMSC210 Metal working fluids (Trim SC210) 52 *

TRIMVX Metal Working Fluids: Trim VX 34 13

TUNGSTENFIB Tungsten Suboxide Fibers 32 5

@ UORFLTRVECTOR Insertional Mutagenesis -

Definitive Vector Study

(Primary CASRN is INSERTMUT3)

33 8

@ UORFLTRVECTOR Insertional Mutagenesis -

Definitive Vector Study

(Primary CASRN is INSERTMUT3)

32 4

URETHCOMB Urethane + ethanol (combination) 37 16

URETHCOMB Urethane + ethanol (combination) 47 16

USNEALICHEN Usnea Lichen 33 6