**EXHIBIT 31.1**

 

**CERTIFICATION PURSUANT TO SECTION 302**

**OF THE SARBANES-OXLEY ACT OF 2002**

 

I,Stanislaw R. Burzynski, certify that:

 

1.                                       I have reviewed this annual report on Form 10-KSBof Burzynski Research Institute, Inc. (“BRI”);

 

2.                                       Based on my knowledge, this report does notcontain any untrue statement of a material fact or omit to state a materialfact necessary to make the statements made, in light of the circumstances underwhich such statements were made, not misleading with respect to the period coveredby this report;

 

3.                                       Based on my knowledge, the financialstatements, and other financial information included in this report, fairlypresent in all material respects the financial condition, results of operationsand cash flows of BRI as of, and for, the periods presented in this report;

 

4.                                       I am responsible for establishing andmaintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and15d-15(e)) for BRI and have:

 

### **(a)**                                  Designedsuch disclosure controls and procedures, or caused such disclosure controls andprocedures to be designed under my supervision, to ensure that materialinformation relating to BRI, including its consolidated subsidiaries, is madeknown to me by others within those entities, particularly during the period inwhich this report is being prepared;

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### **(b)**                                 Evaluatedthe effectiveness of BRI’s disclosure controls and procedures and presented inthis report my conclusions about the effectiveness of the disclosure controlsand procedures, as of the end of the period covered by this report based onsuch evaluation; and

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### **(c)**                                  Disclosedin this report any change in BRI’s internal control over financial reportingthat occurred during BRI’s most recent fiscal quarter (BRI’s fourth fiscalquarter in the case of an annual report) that has materially affected, or isreasonably likely to materially affect, BRI’s internal control over financialreporting;

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5.                                       I have disclosed, based on my most recentevaluation of internal control over financial reporting, to BRI’s auditors andBRI’s board of directors (or persons performing the equivalent functions of anaudit committee):

 

### **(a)**                                  Allsignificant deficiencies and material weaknesses in the design or operation ofinternal control over financial reporting which are reasonably likely toadversely affect BRI’sabilityto record, process, summarize and report financial information; and

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### **(b)**                                 Anyfraud, whether or not material, that involves management or other employees whohave a significant role in BRI’s internal control over financial reporting.

 

 
| Date:  May 30, 2006 | /s/ Stanislaw R. Burzynski            |
|-------------------------------|---------------------------------------|
|                          | Stanislaw R. Burzynski,               |
|                          | President, Secretary,  Treasurer, and |
|                          | Chairman of the Board of  Directors   |
|                          | (Chief Executive Officer  and         |
|                          | Principal Financial  Officer)         |

 

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