EX-4.2



 Exhibit 4.2 

ZOETIS INC. 
 SECOND
SUPPLEMENTAL INDENTURE 
 Dated as of November 13, 2015 

3.450% Senior Notes due 2020 

4.500% Senior Notes due 2025 

(Second Supplemental Indenture to the Indenture Dated as of January 28, 2013) 

DEUTSCHE BANK TRUST COMPANY AMERICAS, 

as Trustee 







 TABLE OF CONTENTS 

 

							
	 	 	 	  	Page	 
	 ARTICLE I. DEFINITIONS
	  	 	1	  
			
	 Section 1.01.
	 	 Certain Terms Defined in the Indenture; Additional Terms
	  	 	1	  
			
	 Section 1.02.
	 	 Definitions Incorporated into the Indenture
	  	 	2	  
			
	 Section 1.03.
	 	 Reserved
	  	 	7	  
		
	 ARTICLE II. FORM AND TERMS OF THE NOTES
	  	 	7	  
			
	 Section 2.01.
	 	 Form and Dating
	  	 	7	  
			
	 Section 2.02.
	 	 Paying Agent; Depository
	  	 	7	  
			
	 Section 2.03.
	 	 Registration, Transfer and Exchange
	  	 	7	  
			
	 Section 2.04.
	 	 Reserved
	  	 	9	  
			
	 Section 2.05.
	 	 Reserved
	  	 	9	  
			
	 Section 2.06.
	 	 Terms of the Notes
	  	 	9	  
			
	 Section 2.07.
	 	 Optional Redemption
	  	 	10	  
			
	 Section 2.08.
	 	 Special Mandatory Redemption
	  	 	13	  
			
	 Section 2.09.
	 	 Limitation on Liens
	  	 	13	  
			
	 Section 2.10.
	 	 Limitation on Sale and Leaseback Transactions
	  	 	14	  
		
	 ARTICLE III. MISCELLANEOUS
	  	 	14	  
			
	 Section 3.01.
	 	 Trust Indenture Act Controls
	  	 	14	  
			
	 Section 3.02.
	 	 Governing Law
	  	 	14	  
			
	 Section 3.03.
	 	 Multiple Counterparts
	  	 	14	  
			
	 Section 3.04.
	 	 Severability
	  	 	15	  
			
	 Section 3.05.
	 	 Relation to Indenture
	  	 	15	  
			
	 Section 3.06.
	 	 Ratification
	  	 	15	  
			
	 Section 3.07.
	 	 Effectiveness
	  	 	15	  
			
	 Section 3.08.
	 	 Trustee Not Responsible for Recitals or Issuance of Securities
	  	 	15	  


  
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 SECOND SUPPLEMENTAL INDENTURE 

SECOND SUPPLEMENTAL INDENTURE (this “Second Supplemental Indenture”), dated as of November 13, 2015, between Zoetis
Inc., a Delaware corporation (the “Company”), and Deutsche Bank Trust Company Americas, a New York banking corporation, as Trustee (the “Trustee”). 

RECITALS: 
 WHEREAS, the
Company and the Trustee executed and delivered an Indenture, dated as of January 28, 2013 (the “Indenture”), to provide for the issuance by the Company from time to time of Securities to be issued in one or more series as
provided in the Indenture; 
 WHEREAS, the issuance and sale of $500,000,000 aggregate principal amount of a new series of the Securities of
the Company designated as its 3.450% Senior Notes due 2020 (the “2020 Notes”) and $750,000,000 aggregate principal amount of a new series of the Securities of the Company designated as its 4.500% Senior Notes due 2025 (the
“2025 Notes” and, together with the 2020 Notes, the “Notes”) have been authorized by resolutions adopted by the Board of Directors of the Company; 

WHEREAS, the Company desires to issue and sell $1,250,000,000 aggregate principal amount of the Notes on the date hereof; 

WHEREAS, Sections 2.01 and 10.01 of the Indenture provide that the Company, when authorized by a Board Resolution, and the Trustee may amend
or supplement the Indenture to provide for the issuance of and to establish the form or terms and conditions of Securities of any series as permitted by the Indenture; 

WHEREAS, the Company desires to establish the form, terms and conditions of the Notes; and 

WHEREAS, all things necessary to make this Second Supplemental Indenture a legal, valid and binding supplement to the Indenture according to
its terms and the terms of the Indenture have been done; 
 NOW, THEREFORE, for and in consideration of the premises stated herein and the
purchase of the Notes by the Holders thereof, the parties hereto hereby enter into this Second Supplemental Indenture, for the equal and proportionate benefit of all Holders of the Notes, as follows: 

ARTICLE I. 
 DEFINITIONS 

Section 1.01. Certain Terms Defined in the Indenture; Additional Terms. For purposes of this Second Supplemental Indenture, all
capitalized terms used but not defined herein shall have the meanings ascribed to such terms in the Indenture, as amended hereby. The following capitalized terms used herein shall be defined accordingly: 

“Agent Member” means a member of, or a participant in, the Depository. 







 “Certificated Note” means a Note in registered certificated form. 

“DTC Legend” means the legend set forth in Exhibit C. 

“Global Note” means a Note in registered global form. 

“Issue Date” means the date on which the Notes are originally issued under this Indenture. 

“Securities Act” means the Securities Act of 1933, as amended. 

Section 1.02. Definitions Incorporated into the Indenture. For the benefit of the Holders of the Notes, Section 1.01 of the
Indenture shall be amended by adding the following new definitions: 
 “Additional Notes” shall have the meaning set forth
in Section 2.06(b) of this Indenture 
 “Acquisition” means the acquisition of all of the outstanding share capital of
Salar Topco AS, a Norwegian limited liability company, pursuant to the Purchase Agreement. 
 “Below Investment Grade Rating
Event” means Notes are rated below Investment Grade Rating by both of the Rating Agencies on any date commencing upon the first public notice by the Company of the occurrence of a Change of Control and ending 60 days following consummation
of such Change of Control (which period shall be extended up to an additional 60 days, so long as the rating of the Notes is under publicly announced consideration for possible downgrade by either of the Rating Agencies); provided that a
Below Investment Grade Rating Event will not be deemed to have occurred in respect of a particular Change of Control (and thus will not be deemed a Below Investment Grade Rating Event for purposes of the definition of Change of Control Triggering
Event) if each Rating Agency making the reduction in rating does not publicly announce or confirm or inform the Company in writing at its request that the reduction was the result, in whole or in part, of any event or circumstance comprised of or
arising as a result of, or in respect of, the Change of Control. 
 “Change of Control” means the occurrence of any of the
following: (1) the direct or indirect sale, transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or more series of related transactions, of all or substantially all of the assets of the Company and
the assets of its Subsidiaries, taken as a whole, to one or more “persons” (as that term is used in Section 13(d)(3) of the Exchange Act) (other than to the Company or one of its Subsidiaries); (2) the consummation of any
transaction (including, without limitation, any merger or consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act ) becomes the beneficial owner (as defined in Rules 13d-3
and 13d-5 under the Exchange Act), directly or indirectly, of more than 50% of the voting stock of the Company or other voting stock into which the voting stock of the Company is reclassified, consolidated, exchanged or changed, measured by voting
power rather than number of shares; provided, however, that a transaction will not be deemed to involve a Change of Control if (a) the Company becomes a direct or indirect wholly owned subsidiary of a


  
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holding company and (b) the holders of the voting stock of such holding company immediately following that transaction are substantially the same as the holders of the voting stock of the
Company immediately prior to that transaction; (3) the Company consolidates with, or merges with or into, any “person” or “group” (as that term is used in Section 13(d)(3) of the Exchange Act) or any such person or
group consolidates with, or merges with or into, the Company, in either case, pursuant to a transaction in which any of the Company’s outstanding voting stock or the voting stock of such other person is converted into or exchanged for cash,
securities or other property, other than pursuant to a transaction in which shares of the voting stock of the Company outstanding immediately prior to the transaction constitute, or are converted into or exchanged for, a majority of the voting stock
of the surviving person immediately after giving effect to such transaction; (4) the first day on which a majority of the members of the Board of Directors of the Company are not Continuing Directors; or (5) the adoption of a plan relating
to the Company’s liquidation or dissolution; provided that for purposes of this definition “voting stock” means with respect to any specified person (as that term is used in Section 13(d)(3) of the Exchange Act) capital
stock of any class or kind the holders of which are ordinarily, in the absence of contingencies, entitled to vote for the election of directors (or persons performing similar functions) of such person, even if the right to vote has been suspended by
the happening of such a contingency. 
 “Change of Control Offer” shall have the meaning set forth in Section 3.09 of
the Indenture. 
 “Change of Control Payment” shall have the meaning set forth in Section 3.09 of the Indenture. 

“Change of Control Payment Date” shall have the meaning set forth in Section 3.09 of the Indenture. 

“Change of Control Triggering Event” means the occurrence of both a Change of Control and a Below Investment Grade Rating
Event. 
 “Comparable Treasury Issue” means, for any series of Notes, the United States Treasury security selected by an
Independent Investment Banker as having a maturity comparable to the remaining term of the Notes of such series to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new
issues of corporate debt securities of a comparable maturity to the remaining term of the Notes of such series. 
 “Comparable
Treasury Price” means, with respect to any Redemption Date, and series of Notes to be redeemed, (A) the average of the Reference Treasury Dealer Quotations for such Redemption Date, after excluding the highest and lowest such Reference
Treasury Dealer Quotations, (B) if the Independent Investment Banker obtains fewer than four such Reference Treasury Dealer Quotations, the average of such quotations, or (C) if only one such Reference Treasury Dealer Quotation is
received, such Reference Treasury Dealer Quotation. 
 “Consolidated Net Tangible Assets” means the aggregate amount of
assets after deducting (a) all current liabilities (excluding any indebtedness maturing within 12 months of the end of the most recent quarter for which financial statements are available) and (b) all goodwill, trade names, patents,
unamortized debt discount and expense and any other like intangibles. 

  
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 “Continuing Director” means, as of any date of determination, any member of the
Board of Directors of the Company who (1) was a member of such Board of Directors on the date the Notes were originally issued, or (2) was nominated for election, or elected to such Board of Directors with the approval of a majority of the
Continuing Directors who were members of the Board of Directors of the Company at the time of such nomination or election (either by a specific vote or by approval of the proxy statement of the Company in which such member was named as a nominee for
election as a director). 
 “Debt” of any Person means (a) all obligations of such Person for borrowed money, or
evidenced by bonds, debentures, notes or other similar instruments (other than any such obligations to the extent that (i) the liability of such Person is limited solely to the property or asset financed by such obligations or (ii) such
obligations result from the requirement to return collateral posted to such Person by a counterparty pursuant to one or more hedging contracts or other similar risk management contracts) and (b) all Debt of others guaranteed by such Person.

 “Exchange Act” means the Securities Exchange Act of 1934, as amended. 

“Independent Investment Banker” means one of the Reference Treasury Dealers appointed by the Company to act as the
“Independent Investment Banker.” 
 “Initial Lien” shall have the meaning set forth in Section 2.09 of this
Indenture 
 “Investment Grade Rating” means a rating by Moody’s equal to or higher than Baa3 (or the equivalent under
a successor rating category of Moody’s) or a rating by S&P equal to or higher than BBB- (or the equivalent under any successor rating category of S&P). 

“Lien” means, with respect to any property of any Person, any mortgage or deed of trust, pledge, hypothecation, assignment,
deposit arrangement, security interest, lien, charge, easement (other than any easement not materially impairing usefulness or marketability), encumbrance, preference, priority or other security agreement or preferential arrangement of any kind or
nature whatsoever on or with respect to such property. 
 “Moody’s” means Moody’s Investors Service, Inc., and
any successor to its rating agency business. 
 “Notes” shall have the meaning set forth in the preamble to this Indenture

 “Permitted Liens” means (1) Liens existing on the date of this Second Supplemental Indenture or Liens existing on
facilities of any Person at the time it becomes a Subsidiary of the Company; (2) Liens on property owned by a Person existing at the time such Person is merged with or into or consolidated with the Company or any of its Subsidiaries;
provided that such Liens were in existence prior to the contemplation of such merger or consolidation and do not extend to any assets other than those of the Person merged into or consolidated with the Company or such Subsidiary;
(3) Liens on property existing at the time of acquisition thereof by the Company or any of its Subsidiaries; provided that such Liens were in existence prior to the 

  
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contemplation of such acquisition and do not extend to any property other than the property so acquired by the Company or such Subsidiary; (4) a Lien on any asset or improvement to any asset
securing Debt incurred or assumed for the purpose of financing all or any part of the cost of acquiring or improving (including constructing) such asset, if such Lien attaches to such asset concurrently with or within 12 months after its acquisition
or improvement (including the completion of construction) and the principal amount of the Debt secured by such Lien, together with all other Debt secured by a Lien on such property, does not exceed the purchase price of such property or the cost of
such improvement; (5) any Lien arising by reason of deposits with, or the giving of any form of security to, any governmental agency or any body created or approved by law or governmental regulation; (6) Liens securing Debt of a Restricted
Subsidiary of the Company owed to the Company or another Restricted Subsidiary of the Company; (7) any extension, renewal or replacement (or successive extensions, renewals or replacements) in whole or in part of any Lien referred to in clauses
(1) through (6) above, inclusive, so long as (i) the principal amount of the Debt secured thereby does not exceed the principal amount of Debt so secured at the time of the extension, renewal or replacement (except that, where an
additional principal amount of Debt is incurred to provide funds for the completion of a specific project, the additional principal amount, and any related financing costs, may be secured by the Lien as well) and (ii) the Lien is limited to the
same property subject to the Lien so extended, renewed or replaced (and improvements on the property); and (8) Liens on any Principal Property not described in clauses (1) through (7) above securing Debt that, together with
(i) the aggregate amount of all other outstanding Debt secured by all other Liens on Principal Property not described in clauses (1) through (7) above and (ii) the aggregate amount of Value in respect of all Sale and Leaseback
Transactions that would otherwise be prohibited by Section 2.09 hereof do not exceed 15% of the Company’s Consolidated Net Tangible Assets measured as of the end of the most recent quarter for which financial statements are available. 

“Principal Property” means any building, structure or other facility together with the underlying land and its fixtures, used
primarily for manufacturing, processing or production, owned in the United States and the net book value of such building, structure or other facility exceeds 2% of the Company’s Consolidated Net Tangible Assets measured as of the end of the
most recent quarter for which financial statements are available; provided that no building, structure or other facility will be a Principal Property if, in the good faith opinion of the Board of Directors of the Company (or a committee
thereof), such building, structure or other facility is not of material importance to the Company’s business taken as a whole. 

“Purchase Agreement” means the Purchase Agreement, dated November 2, 2015, among the Company, SalarLux Parent
S.à.r.l., a Luxembourg limited liability company, and Salar Invest AS, a Norwegian limited liability company, relating to the acquisition of all of the outstanding share capital of Salar Topco AS, a Norwegian limited liability company. 

“Rating Agencies” means (1) Moody’s and S&P; and (2) if either or both of Moody’s or S&P ceases
to rate the notes or fails to make a rating of the notes publicly available for reasons outside of the Company’s control, a “nationally recognized statistical rating organization” within the meaning of Section 3(a)(62) under the
Exchange Act, selected by the Company (as certified by a resolution of the Board of Directors of the Company) as a replacement agency for either Moody’s, S&P, or both of them, as the case may be 

  
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 “Reference Treasury Dealer” means (A) any of Merrill Lynch, Pierce,
Fenner & Smith Incorporated, Barclays Capital Inc., Citigroup Global Markets Inc. and J.P. Morgan Securities LLC (or their respective affiliates that are Primary Treasury Dealers), and their respective successors; provided, however,
that if any of the foregoing shall cease to be a primary U.S. Government securities dealer in the United States (a “Primary Treasury Dealer”), the Company will substitute therefor another Primary Treasury Dealer; and (B) any
other Primary Treasury Dealer(s) selected by the Company. 
 “Reference Treasury Dealer Quotation” means, with respect to
each Reference Treasury Dealer and any Redemption Date of series of Notes to be redeemed, the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue (expressed in each case as a
percentage of its principal amount) quoted in writing to the Independent Investment Banker by such Reference Treasury Dealer at 5:00 p.m. New York City time on the third Business Day preceding such Redemption Date. 

“Restricted Subsidiary” means any of the Company’s Subsidiaries that owns a Principal Property. 

“S&P” means Standard & Poor’s Rating Services, a Standard & Poor’s Financial Services LLC
business and any successor to its rating agency business. 
 “Sale and Leaseback Transaction” means any direct or indirect
arrangement relating to property now owned or hereafter acquired whereby the Company or a Restricted Subsidiary transfers such property to another Person and the Company or a Restricted Subsidiary leases or rents it from such Person (other than
(i) leases between the Company and a Restricted Subsidiary or between Restricted Subsidiaries, (ii) temporary leases for a term, including renewals at the option of the lessee, of not more than three years and (iii) leases of a
property executed by the time of, or within 90 days after the latest of, the acquisition, the completion of construction or improvement, or the commencement of commercial operation of the property). 

“Special Mandatory Redemption Date” means the earlier to occur of (1) June 1, 2016, or (2) the 30th day (or if such day is not a business day, the first business day thereafter) following termination of the Purchase Agreement, in each case after a Special Mandatory Redemption Trigger Date. 

“Special Mandatory Redemption Price” means, with respect to the 2020 Notes, 101% of the aggregate principal amount of the
2020 Notes together with accrued and unpaid interest to, but excluding, the Special Mandatory Redemption Date. 
 “Special Mandatory
Redemption Trigger Date” shall have the meaning set forth in Section 3.10 of the Indenture. 
 “Treasury
Rate” means, with respect to any Redemption Date for any series of Notes, the rate per annum equal to the semi-annual equivalent yield to maturity of the applicable Comparable Treasury Issue, assuming a price for the applicable Comparable
Treasury Issue (expressed as a percentage of its principal amount) equal to the applicable Comparable Treasury Price for such Redemption Date. 

  
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 “Value” means, with respect to a Sale and Leaseback Transaction, an amount equal
to the present value of the lease payments with respect to the term of the lease remaining on the date as of which the amount is being determined, without regard to any renewal or extension options contained in the lease, discounted at the weighted
average interest rate of all series of Securities issued pursuant to the Indenture and having the benefit of the covenants described in Sections 5.05 and 5.06 of the Indenture (including the effective interest rate of any original issue discount
Securities) which are outstanding on the date of such Sale and Leaseback Transaction. 
 Section 1.03. Reserved. 

ARTICLE II. 
 FORM AND TERMS OF THE
NOTES 
 Section 2.01. Form and Dating. (a) The 2020 Notes and the Trustee’s certificate of authentication shall be
substantially in the form of Exhibit A attached hereto. The 2025 Notes and the Trustee’s certificate of authentication shall be substantially in the form of Exhibit B attached hereto. The Notes shall be executed on behalf of the Company by any
Officer and attested by its Secretary or one of its Assistant Secretaries. The signature of any of these Officers on the Notes may be manual or facsimile. The Notes may have notations, legends or endorsements required by law, stock exchange rules or
usage. Each Note shall be dated the date of its authentication. The Notes shall be in denominations of $2,000 and higher integral multiples of $1,000 in excess thereof. 

The terms and notations contained in the Notes shall constitute, and are hereby expressly made, a part of the Indenture as supplemented by
this Second Supplemental Indenture and the Company and the Trustee, by their execution and delivery of this Second Supplemental Indenture, expressly agree to such terms and provisions and to be bound thereby. 

(b) Each Global Note will bear the DTC Legend. 

Section 2.02. Paying Agent; Depository. (a) The Company appoints the Trustee as the initial agent of the Company for the
payment of the principal of (and premium, if any) and interest on the Notes, and the office of the Trustee located in the Borough of Manhattan, the City of New York, be and hereby is, designated as the office or agency where the Notes may be
presented for payment and where notices to or demands upon the Company in respect of the Notes and the Indenture pursuant to which the Notes are to be issued may be served. The Company may at any time designate additional Paying Agents or rescind
the designation of any Paying Agent or approve a change in the office through which the Paying Agent acts. 
 (b) The Depository shall
initially be DTC and any and all successors thereto appointed as Depository by the Company. 
 Section 2.03. Registration, Transfer
and Exchange. (a) Each Global Note will be registered in the name of the Depository or its nominee and, so long as DTC is serving as the Depository thereof, will bear the DTC Legend. 

(i) Each Global Note will be delivered to the Trustee as custodian for the Depository. Transfers of a Global Note (but not a
beneficial interest therein) will be 

  
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limited to transfers thereof in whole, but not in part, to the Depository, its successors or their respective nominees, except (y) as set forth in (iii) of this Section 2.03(a) and
(z) transfers of portions thereof in the form of Certificated Notes may be made upon request of an Agent Member (for itself or on behalf of a beneficial owner) by written notice given to the Trustee by or on behalf of the Depository in
accordance with customary procedures of the Depository and in compliance with this Section 2.03. 
 (ii) Agent Members
will have no rights under this Indenture with respect to any Global Note held on their behalf by the Depository, and the Depository may be treated by the Company, the Trustee and any agent of the Company or the Trustee as the absolute owner and
Holder of such Global Note for all purposes whatsoever. Notwithstanding the foregoing, the Depository or its nominee may grant proxies and otherwise authorize any Person (including any Agent Member and any Person that holds a beneficial interest in
a Global Note through an Agent Member) to take any action which a Holder is entitled to take under this Indenture or the Notes, and nothing herein will impair, as between the Depository and its Agent Members, the operation of customary practices
governing the exercise of the rights of a holder of any security. 
 (iii) If (x) the Depository notifies the Company
that it is unwilling or unable to continue as Depository for a Global Note and a successor depositary is not appointed by the Company within 90 days of such notice or (y) an Event of Default has occurred and is continuing and the Trustee has
received a written request from the Depository, the Trustee will promptly exchange each beneficial interest in the Global Note for one or more Certificated Notes in authorized denominations having an equal aggregate principal amount registered in
the name of the owner of such beneficial interest, as identified to the Trustee by the Depository, and thereupon the Global Note will be deemed canceled. 

(b) Each Certificated Note will be registered in the name of the Holder thereof or its nominee. 

(c) (i) Global Note to Global Note. If a beneficial interest in a Global Note is transferred or exchanged for a beneficial interest in
another Global Note, the Trustee will (y) record a decrease in the principal amount of the Global Note being transferred or exchanged equal to the principal amount of such transfer or exchange and (z) record a like increase in the
principal amount of the other Global Note. Any beneficial interest in one Global Note that is transferred to a Person who takes delivery in the form of an interest in another Global Note, or exchanged for an interest in another Global Note, will,
upon transfer or exchange, cease to be an interest in such Global Note and become an interest in the other Global Note and, accordingly, will thereafter be subject to all transfer and exchange restrictions, if any, and other procedures applicable to
beneficial interests in such other Global Note for as long as it remains such an interest. 
 (ii) Global Note to
Certificated Note. If a beneficial interest in a Global Note is transferred or exchanged for a Certificated Note, the Trustee will (y) record a decrease in the principal amount of such Global Note equal to the principal amount of such
transfer or exchange and (z) deliver one or more new Certificated Notes in authorized denominations having an equal aggregate principal amount to the transferee (in the case of a transfer) or the owner of such beneficial interest (in the case
of an exchange), registered in the name of such transferee or owner, as applicable. 

  
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 (iii) Certificated Note to Global Note. If a Certificated Note is
transferred or exchanged for a beneficial interest in a Global Note, the Trustee will (x) cancel such Certificated Note, (y) record an increase in the principal amount of such Global Note equal to the principal amount of such transfer or
exchange and (z) in the event that such transfer or exchange involves less than the entire principal amount of the canceled Certificated Note, deliver to the Holder thereof one or more new Certificated Notes in authorized denominations having
an aggregate principal amount equal to the untransferred or unexchanged portion of the canceled Certificated Note, registered in the name of the Holder thereof. 

(iv) Certificated Note to Certificated Note. If a Certificated Note is transferred or exchanged for another Certificated
Note, the Trustee will (x) cancel the Certificated Note being transferred or exchanged, (y) deliver one or more new Certificated Notes in authorized denominations having an aggregate principal amount equal to the principal amount of such
transfer or exchange to the transferee (in the case of a transfer) or the Holder of the canceled Certificated Note (in the case of an exchange), registered in the name of such transferee or Holder, as applicable, and (z) if such transfer or
exchange involves less than the entire principal amount of the canceled Certificated Note, deliver to the Holder thereof one or more Certificated Notes in authorized denominations having an aggregate principal amount equal to the untransferred or
unexchanged portion of the canceled Certificated Note, registered in the name of the Holder thereof. 
 Notwithstanding anything to the contrary herein,
this Section 2.03 will become effective immediately after the authentication and delivery of Global Notes evidencing $500,000,000 aggregate principal amount of the 2020 Notes and $750,000,000 aggregate principal amount of the 2025 Notes. 

Section 2.04. Reserved. 

Section 2.05. Reserved. 

Section 2.06. Terms of the Notes. The following terms relating to the Notes are hereby established: 

(a) Title. The 2020 Notes shall constitute a series of Securities having the title “3.450% Senior Notes due 2020,” and the
2025 Notes shall constitute a separate series of Securities having the title “4.500% Senior Notes due 2025.” 
 (b) Principal
Amount. The aggregate principal amount of the 2020 Notes that may be initially authenticated and delivered under the Indenture (except for 2020 Notes authenticated and delivered upon registration of, transfer of, or in exchange for, or in lieu
of, other 2020 Notes pursuant to Sections 2.03, 2.06, 2.07, 3.07 or 10.06 of the Indenture) shall be $500,000,000. The aggregate principal amount of the 2025 Notes that may be initially authenticated and delivered under the Indenture (except for
2025 Notes authenticated and delivered upon registration of, transfer of, or in exchange for, or in lieu of, other 2025 Notes pursuant to Sections 2.03, 2.06, 

  
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2.07, 3.07 or 10.06 of the Indenture) shall be $750,000,000. The Company may from time to time, without the consent of the Holders of Notes of any series, issue additional Notes (in any such case
“Additional Notes”) of any series having the same ranking and the same interest rate, maturity and other terms as the Notes of that series, except for the issue date, the public offering price and, in some cases, the first Interest
Payment Date. Any Additional Notes of a series and the existing Notes of that series will constitute a single series under the Indenture and all references to the relevant Notes shall include the Additional Notes unless the context otherwise
requires; provided that no Event of Default with respect to the Notes shall have occurred and be continuing; provided further that if any such Additional Securities are not fungible with the Notes for U.S. federal income tax purposes,
such Additional Securities shall have a separate CUSIP number and shall not constitute a single series with such Notes. 
 (c) Maturity
Date. The entire outstanding principal of the 2020 Notes shall be payable on November 13, 2020 and the entire outstanding principal of the 2025 Notes shall be payable on November 13, 2025. 

(d) Interest Rate. The rate at which the 2020 Notes shall bear interest shall be 3.450% per annum and the rate at which the 2025
Notes shall bear interest shall be 4.500% per annum; the date from which interest shall accrue on the Notes shall be November 13, 2015, or the most recent Interest Payment Date to which interest has been paid or provided for; the Interest
Payment Dates for the Notes shall be May 13 and November 13 of each year, beginning May 13, 2016; the interest so payable, and punctually paid or duly provided for, on any Interest Payment Date, will be paid, in immediately available
funds, to the Persons in whose names the Notes (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be the April 28 or October 29, as the case may be, next
preceding such Interest Payment Date. Payment of principal and interest on the Notes will be made at the Corporate Trust Office of the Trustee or such other office or agency of the Company as may be designated for such purpose, in such currency of
the United States of America as at the time of payment is legal tender for payment of public and private debts; provided, however, that each installment of interest and principal on the Notes may at the Company’s option be paid in
immediately available funds by transfer to an account maintained by the payee located in the United States of America. 
 (e)
Currency. The currency of denomination of the Notes is United States Dollars. Payment of principal of and interest and premium, if any, on the Notes will be made in United States Dollars. 

Section 2.07. Optional Redemption. (a) The provisions of Article 3 of the Indenture shall apply to the Notes. 

(b) For the benefit of the Holders of the Notes, a new Section 3.08 shall be added to the Indenture as follows: 

“Section 3.08. Notice to Holders; Redemption Price; etc. 

(a) At any time and from time to time, the Notes of each series will be redeemable, as a whole or in part, at the Company’s option, on


  
 10 








 
at least 30 days, but not more than 60 days, prior notice mailed to the registered address of each holder of the Notes of the applicable series, or by the Trustee for transmission to the
Depository or its nominee at the written request and at the expense of the Company or such other notice method in accordance with the Indenture as determined by a resolution of the Board of Directors of the Company or a certificate executed by
certain Officers of the Company, at a redemption price equal to the greater of (i) 100% of principal amount of the Notes to be redeemed, and (ii) the sum of the present values of the remaining scheduled payments of interest and principal
thereon (not including the amount of accrued and unpaid interest to, but excluding, the date of redemption) discounted to the date of redemption on a semiannual basis, assuming a 360-day year consisting of twelve 30-day months, at the Treasury Rate,
as determined by the Reference Treasury Dealer, plus 30 basis points in the case of the 2020 Notes and 35 basis points in the case of the 2025 Notes, plus, in the case of either (i) or (ii), accrued and unpaid interest to, but excluding,
the date of redemption; provided that the principal amount of any Note remaining outstanding after a redemption in part shall be $2,000 or a higher integral multiple of $1,000; provided further, however, that if the Company redeems the
2020 Notes on or after October 13, 2020, the redemption price will equal 100% of the principal amount of the 2020 Notes to be redeemed plus accrued and unpaid interest on the amount being redeemed to, but excluding, the date of redemption;
provided further, however, that if the Company redeems the 2025 Notes on or after August 13, 2025, the redemption price will equal 100% of the principal amount of the 2025 Notes to be redeemed plus accrued and unpaid interest on the
amount being redeemed to, but excluding, the date of redemption. 
 (b) On and after the Redemption Date for the Notes of any series,
interest will cease to accrue on the Notes of such series or any portion thereof called for redemption, unless the Company defaults in the payment of the redemption price. By 10:00 a.m. New York City time on, or before, the Redemption Date for the
Notes of such series, the Company will deposit with a Paying Agent, or the Trustee, funds sufficient to pay the redemption price of and accrued and unpaid interest on the Notes to be redeemed on such date. If less than all of the Notes of a series
are to be redeemed, the Notes of that series to be redeemed will be selected by the Trustee in accordance with the procedures of DTC.” 

  
 11 








 (c) For the benefit of the Holders of the Notes, a new Section 3.09 shall be added to the
Indenture as follows: 
 “Section 3.09. Repurchase of Notes Upon a Change of Control. 

(a) If a Change of Control Triggering Event occurs with respect to the Notes, unless the Company shall have exercised its option to redeem the
Notes as described in Section 3.09 of this Indenture, the Company shall be required to make an offer (the “Change of Control Offer”) to each Holder to repurchase all or any part (equal to $2,000 principal amount or a higher
integral multiple of $1,000) of such Holder’s Notes on the terms set forth in this Section 3.09 and in the Notes. In the Change of Control Offer, the Company shall offer payment in cash equal to 101% of the aggregate principal amount of
Notes repurchased, plus accrued and unpaid interest, if any, on the Notes repurchased to but excluding the date of repurchase (the “Change of Control Payment”). With respect to the Notes of each series, within 30 days
following any Change of Control Triggering Event the Company shall mail a notice to Holders of Notes of the applicable series, with a copy to the Trustee, describing the transaction or transactions that constitute or may constitute the Change of
Control Triggering Event and offering to repurchase the Notes on the date specified in the notice, which date shall be no earlier than 30 days and no later than 60 days from the date such notice is mailed (the “Change of Control Payment
Date”). 
 (b) On the Change of Control Payment Date, the Company shall, to the extent lawful: 

(1) accept for payment all Notes or portions of Notes properly tendered pursuant to the Change of Control Offer; 

(2) deposit with the Paying Agent an amount equal to the Change of Control Payment in respect of all Notes or portions of
Notes properly tendered; and 
 (3) deliver or cause to be delivered to the Trustee the Notes properly accepted together
with an Officers’ Certificate stating the aggregate principal amount of Notes or portions of Notes being repurchased. 
 (c) The Company
shall not be required to make a Change of Control Offer upon the occurrence of a Change of Control Triggering Event if a third party makes such an offer in the manner, at the times and otherwise in compliance with the requirements for an offer made
by the Company and the third party repurchases all Notes properly tendered and not withdrawn under its offer. 

  
 12 








 (d) The Company shall comply in all material respects with the requirements of Rule 14e-1 under
the Exchange Act and any other securities laws and regulations thereunder to the extent such laws and regulations are applicable in connection with the repurchase of the Notes as a result of a Change of Control Triggering Event. To the extent that
the provisions of any such securities laws or regulations conflict with this Section 3.09, the Company shall comply with the applicable securities laws and regulations and shall not be deemed to have breached its obligations under this
Section 3.09 by virtue of any such conflict.” 
 Section 2.08. Special Mandatory Redemption. A new Section 3.10
shall be added to the Indenture as follows: 
 “Section 3.10. Special Mandatory Redemption. 

(a) If the Acquisition has not been consummated by May 1, 2016 or if, prior to such date, the Purchase Agreement is terminated for any
reason (the “Special Mandatory Redemption Trigger Date”), the 2020 Notes shall become due and payable on the Special Mandatory Redemption Date at the Special Mandatory Redemption Price. 

(b) Notice of a special mandatory redemption will be mailed, with a copy to the Trustee, within ten business days after the occurrence of an
event triggering such redemption to each Holder of 2020 Notes at its registered address. If funds sufficient to pay the Special Mandatory Redemption Price of all of the 2020 Notes to be redeemed on the Special Mandatory Redemption Date (plus accrued
and unpaid interest, if any, to the Special Mandatory Redemption Date) are deposited with the Paying Agent on or before such Special Mandatory Redemption Date, on and after such Special Mandatory Redemption Date, the 2020 Notes will cease to bear
interest and, other than the right to receive the Special Mandatory Redemption Price, all rights under the 2020 Notes shall terminate.” 

Section 2.09. Limitation on Liens. For the benefit of the Holders of the Notes, a new Section 5.05 shall be added to the
Indenture as follows: 
 “The Company shall not, and shall not permit any Restricted Subsidiary of the Company to,
create, assume or suffer to exist any Lien (an “Initial Lien”), other than Permitted Liens, on any Principal Property to secure any Debt of the Company or any Restricted Subsidiary unless it has made or will make effective provision
whereby the Notes and any other debt securities of any series issued pursuant to the Indenture and 

  
 13 








 
having the benefit of this Section 5.05 will be secured by such Lien equally and ratably with (or prior to) all other Debt secured by such Lien. Any Lien created for the benefit of the
Holders of the Notes and any other debt securities of any series issued pursuant to this Indenture and having the benefit of this Section 5.05 shall provide by its terms that such Lien will be automatically released and discharged upon the
release and discharge of the applicable Initial Lien.” 
 Section 2.10. Limitation on Sale and Leaseback Transactions. For
the benefit of the Holders of the Notes, a new Section 5.06 shall be added to the Indenture as follows: 
 “The
Company shall not, and shall not permit any Restricted Subsidiary to, enter into any Sale and Leaseback Transaction covering any Principal Property, unless (i) pursuant to Section 5.05 of this Indenture, the Company or the Restricted
Subsidiary would be entitled to incur Debt secured by a Lien on such Principal Property in a principal amount equal to the Value of such Sale and Leaseback Transaction without equally and ratably securing the Notes and any other debt securities of
any series issued pursuant to the Indenture and having the benefit of this Section 5.06; or (ii) the Company or any Restricted Subsidiary, during the 270 days following the effective date of the Sale and Leaseback Transaction, applies an
amount equal to the Value of such Sale and Leaseback Transaction to the voluntary retirement of long-term Debt of the Company or any Restricted Subsidiary or to the acquisition of one or more Principal Properties.” 

ARTICLE III. 
 MISCELLANEOUS 

Section 3.01. Trust Indenture Act Controls. If any provision of this Second Supplemental Indenture limits, qualifies or conflicts
with another provision which is required to be included in this Second Supplemental Indenture by the Trust Indenture Act, the required provision shall control. If any provision of this Second Supplemental Indenture modifies or excludes any provision
of the Trust Indenture Act which may be so modified or excluded, the latter provision shall be deemed to apply to this Second Supplemental Indenture as so modified or to be excluded, as the case may be. 

Section 3.02. Governing Law. This Second Supplemental Indenture and the Notes shall be governed by and construed in accordance
with the laws of the State of New York, without giving effect to any choice of law or conflict of law provision or rule that would cause the application of the laws of any other jurisdiction. 

Section 3.03. Multiple Counterparts. The parties may sign multiple counterparts of this Second Supplemental Indenture. Each signed
counterpart shall be deemed an original, but all of them together represent one and the same Second Supplemental Indenture. 

  
 14 








 Section 3.04. Severability. Each provision of this Second Supplemental Indenture
shall be considered separable and if for any reason any provision which is not essential to the effectuation of the basic purpose of this Second Supplemental Indenture or the Notes shall be invalid, illegal or unenforceable, the validity, legality
and enforceability of the remaining provisions shall not in any way be affected or impaired thereby and a Holder shall have no claim therefor against any party hereto. 

Section 3.05. Relation to Indenture. This Second Supplemental Indenture constitutes a part of the Indenture, the provisions of
which (as modified by this Second Supplemental Indenture) shall apply to the series of Securities established by this Second Supplemental Indenture but shall not modify, amend or otherwise affect the Indenture insofar as it relates to any other
series of Securities or modify, amend or otherwise affect in any manner the terms and conditions of the Securities of any other series. 

Section 3.06. Ratification. The Indenture, as supplemented and amended by this Second Supplemental Indenture, is in all respects
ratified and confirmed. The Indenture and this Second Supplemental Indenture shall be read, taken and construed as one and the same instrument. All provisions included in this Second Supplemental Indenture supersede any conflicting provisions
included in the Indenture unless not permitted by law. The Trustee accepts the trusts created by the Indenture, as supplemented by this Second Supplemental Indenture, and agrees to perform the same upon the terms and conditions of the Indenture, as
supplemented by this Second Supplemental Indenture. 
 Section 3.07. Effectiveness. The provisions of this Second Supplemental
Indenture shall become effective as of the date hereof. 
 Section 3.08. Trustee Not Responsible for Recitals or Issuance of
Securities. The recitals contained herein and in the Securities, except the Trustee’s certificates of authentication, shall be taken as the statements of the Company, and the Trustee or any Authenticating Agent assumes no responsibility for
their correctness. The Trustee makes no representations as to the validity or sufficiency of this Second Supplemental Indenture or of the Securities. The Trustee or any Authenticating Agent shall not be accountable for the use or application by the
Company of Securities or the proceeds thereof. In the performance of its obligations hereunder, the Trustee shall be provided with all rights, benefits, protections, indemnities and immunities afforded to it pursuant to the Base Indenture. 

[Remainder of this page intentionally left blank] 

  
 15 








 IN WITNESS WHEREOF, the parties hereto have caused this Second Supplemental Indenture to be duly
executed as of the date first above written. 
  

			
	ZOETIS INC.,
	as the Company
		
	By:	 	 /s/ Heidi C. Chen

	Name:	 	Heidi C. Chen
	Title:	 	Executive Vice President, General
		 	Counsel and Corporate Secretary



  
 [Signature Page to
Second Supplemental Indenture] 








 
			
	DEUTSCHE BANK TRUST COMPANY AMERICAS,
	as Trustee
		
	By:	 	Deutsche Bank National Trust Company
		
	By:	 	 /s/ Kathryn Fischer

	Name:	 	Kathryn Fischer
	Title:	 	Assistant Vice President
		
	By:	 	 /s/ Chris Niesz

	Name:	 	Chris Niesz
	Title:	 	Assistant Vice President



  
 [Signature Page to
Second Supplemental Indenture] 








 EXHIBIT A 

Form of 3.450% Senior Note due 2020 

ZOETIS INC. 
 3.450%
SENIOR NOTE DUE 2020 
 PRINCIPAL AMOUNT 
  

			
	No.                     	  	$[●]
		
	CUSIP:                     	  	
	ISIN:                     	  	

 Zoetis Inc., a Delaware corporation (herein called the “Company,” which term includes any
successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede &Co., or registered assigns, the principal sum of $[●], or such greater or lesser amount set forth in the attached Schedule
of Increases and Decreases in Global Note, on November 13, 2020 (the “Maturity Date”) (except to the extent redeemed or repaid prior to the Maturity Date) and to pay interest thereon from November 13, 2015 (the
“Original Issue Date”) or from the most recent Interest Payment Date to which interest has been paid or duly provided for semi-annually at the rate of 3.450% per annum, on May 13 and November 13 (each such date, an
“Interest Payment Date”), commencing May 13, 2016, until the principal hereof is paid or made available for payment. 

Payment of Interest. The interest so payable, and punctually paid or made available for payment, by 10:00 a.m. New York time, on any
Interest Payment Date, will, as provided in the Indenture (defined below), be paid, in immediately available funds, to the Person in whose name this Note (or one or more predecessor securities) is registered at the close of business on the
April 28 or October 29 (whether or not a Business Day, as defined in the Indenture), as the case may be, next preceding such Interest Payment Date (the “Regular Record Date”). Any such interest not punctually paid or duly
provided for (“Defaulted Interest”) will forthwith cease to be payable to the Holder on such Regular Record Date, and such Defaulted Interest, may be paid to the Person in whose name this Note (or one or more predecessor securities)
is registered at the close of business on a special record date (the “Special Record Date”) for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Notes not less than ten
days prior to such Special Record Date, or may be paid at any time in any other lawful manner not inconsistent with requirements of any securities exchange on which the Notes may be listed, and upon such notice as may be required by such exchange,
all as more fully provided in said Indenture. 
 Place of Payment. Payment of principal, premium, if any, and interest on this Note
will be made at the Corporate Trust Office of the Trustee or such other office or agency of the Company as may be designated for such purpose, in such currency of the United States of America as at the time of payment is legal tender for payment of
public and private debts; provided, however, that each installment of interest, premium, if any, and principal on this Note may at the Company’s option be paid in immediately available funds by transfer to an account maintained by the
payee located in the United States of America. 

  
 A-1 








 Time of Payment. In any case where any Interest Payment Date, the Maturity Date or any
date fixed for redemption or repayment of the Notes shall not be a Business Day, then (notwithstanding any other provision of the Indenture or this Note), payment of principal or interest, if any, need not be made on such date, but may be made on
the next succeeding Business Day with the same force and effect as if made on such Interest Payment Date, the Maturity Date or the date so fixed for redemption or repayment, and no interest shall accrue in respect of the delay. 

General. This Note is one of a duly authorized issue of Securities of the Company, issued and to be issued in one or more series under
an indenture (the “Base Indenture”), dated as of January 28, 2013, between the Company and Deutsche Bank Trust Company Americas (herein called the “Trustee,” which term includes any successor Trustee under the
Indenture with respect to a series of which this Note is a part), as supplemented by a Second Supplemental Indenture thereto, dated as of November 13, 2015 (the “Second Supplemental Indenture” and, together with the Base
Indenture, the “Indenture”), among the Company and the Trustee. Reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee
and the Holders of the Securities, and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Note is one of a duly authorized series of Securities designated as “3.450% Senior Notes due 2020”
(collectively, the “Notes”), initially limited in aggregate principal amount to $500,000,000. 
 Further Issuance.
The Company may from time to time, without the consent of the Holders of the Notes, issue additional Securities (the “Additional Securities”) of this series having the same ranking and the same interest rate, maturity and other
terms as the Notes. Any Additional Securities of this series and the Notes will constitute a single series under the Indenture and all references to the Notes shall include the Additional Securities unless the context otherwise requires;
provided that no Event of Default with respect to the Notes shall have occurred and be continuing; provided further that if any such Additional Securities are not fungible with the Notes for U.S. federal income tax purposes, such
Additional Securities shall have a separate CUSIP number and shall not constitute a single series with such Notes. 
 Events of
Default. If an Event of Default with respect to the Notes shall have occurred and be continuing, the principal of the Notes may be declared due and payable in the manner and with the effect provided in the Indenture. 

Sinking Fund. The Notes are not subject to any sinking fund. 

Special Mandatory Redemption. If the Acquisition has not been consummated by May 1, 2016 or if, prior to such date, the Purchase
Agreement is terminated, the Notes shall become due and payable on the Special Mandatory Redemption Date at the Special Mandatory Redemption Price. 

  
 A-2 








 Optional Redemption. The Notes will be redeemable at any time, at the option of the
Company, in whole or from time to time in part, upon not less than 30 nor more than 60 days’ prior notice, on any date prior to their Maturity at a redemption price, calculated pursuant to the Indenture, which includes accrued interest thereon,
if any, to, but excluding, the Redemption Date. In the case of any partial redemption, selection of the Notes for redemption will be made by the Trustee in accordance with the procedures of DTC. If any Note is to be redeemed in part only, the notice
of redemption relating to such Note shall state the portion of the principal amount thereof to be redeemed; provided that the principal amount of any Note remaining outstanding after a redemption in part shall be $2,000 or a higher integral
multiple of $1,000. A new Note in principal amount equal to the unredeemed portion thereof will be issued in the name of the Holder thereof upon cancellation of this Note. 

Repurchase upon a Change of Control Triggering Event. Upon the occurrence of a Change of Control Triggering Event with respect to the
Notes, the Company shall be required to make an offer to repurchase the Notes on the terms set forth in the Indenture. 
 Restrictive
Covenants. The Indenture contains certain covenants that, among other things, limit the ability of the Company and its Subsidiaries to create liens or the ability of the Company to consolidate, merge or sell, transfer or lease all or
substantially all of its assets. 
 Defeasance and Covenant Defeasance. The Indenture contains provisions for defeasance at any time
of (a) the entire indebtedness of the Company on this Note and (b) certain restrictive covenants and the related Defaults and Events of Default, upon compliance by the Company with certain conditions set forth therein, which provisions
apply to this Note. 
 Modification and Waivers; Obligations of the Company Absolute. The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series. Such amendment may be effected under the Indenture at any time by the
Company, and the Trustee with the consent of the Holders of not less than a majority in aggregate principal amount of the outstanding Notes of each series affected thereby. The Indenture also contains provisions permitting the Holders of not less
than a majority in aggregate principal amount of the Securities at the time outstanding, on behalf of the Holders of all outstanding Securities, to waive compliance by the Company with certain provisions of the Indenture. Furthermore, provisions in
the Indenture permit the Holders of not less than a majority in aggregate principal amount of the outstanding Securities of individual series to waive on behalf of all of the Holders of Securities of such individual series certain past defaults
under the Indenture and their consequences. Any such consent or waiver shall be conclusive and binding upon the Holder of this Note and upon all future Holders of this Note and of any Note issued upon the registration of transfer hereof or in
exchange hereof or in lieu hereof, whether or not notation of such consent or waiver is made upon this Note. 
 No reference herein to the
Indenture and no provision of this Note or of the Indenture shall alter or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of and interest on this Note at the time, place, and rate, and in the
currency, herein prescribed. 

  
 A-3 








 No Recourse Against Others. No director, officer, agent, employee, incorporator,
stockholder, partner, member, or manager of the Company shall have any liability for any obligations of the Company under any Notes or the Indenture or for any claim based on, in respect of, or by reason of, such obligations or their creation. Each
Holder of the Notes by accepting a Note waives and releases all such liability. The waiver and release are part of the consideration for issuance of the Notes. 

Limitation on Suits. As set forth in, and subject to, the provisions of the Indenture, no Holder of any Note will have any right to
institute any proceeding with respect to the Indenture or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice of a continuing Event of Default with respect to this series, the Holders of not less
than 33% in principal amount of the outstanding Notes shall have made written request, and offered indemnity satisfactory to the Trustee, to the Trustee to institute such proceedings as Trustee, and the Trustee shall not have received from the
Holders of a majority in principal amount of the outstanding Notes a direction inconsistent with such request and shall have failed to institute such proceeding within 60 days; provided, however, that such limitations do not apply to a suit
instituted by the Holder hereof for the enforcement of payment of the principal of or interest on this Note on or after the respective due dates expressed herein. 

Authorized Denominations. The Notes are issuable only in registered form without coupons in minimum denominations of $2,000 and
integral multiples of $1,000 in excess thereof. 
 Registration of Transfer or Exchange. As provided in the Indenture and subject to
certain limitations herein and therein set forth, the transfer of this Note is registrable in the register of the Notes maintained by the Security Registrar upon surrender of this Note for registration of transfer, at the office or agency of the
Company in any place where the principal of and interest on this Note are payable, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company and the Security Registrar, duly executed by the Holder
hereof or his attorney duly authorized in writing, and thereupon one or more new Notes, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

As provided in the Indenture and subject to certain limitations herein and therein set forth, the Notes are exchangeable for a like aggregate
principal amount of Notes of different authorized denominations, as requested by the Holders surrendering the same. 
 No service charge
shall be made for any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Note for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee may
treat the Holder as the owner hereof for all purposes (except with respect to certain payments of Defaulted Interest), whether or not this Note be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the
contrary. 

  
 A-4 








 Defined Terms. All terms used in this Note, which are defined in the Indenture and are not
otherwise defined herein, shall have the meanings assigned to them in the Indenture. 
 Governing Law. This Note shall be governed by
and construed in accordance with the laws of the State of New York. 
 Unless the certificate of authentication hereon has been executed by
the Trustee by manual signature, this Note shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

[Remainder of page intentionally left blank] 

  
 A-5 








 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

Dated:                      

 

			
	ZOETIS INC., as the Company
		
	By:	 	  

	Name:	 	
	Title:	 	


  

			
	Attest:	 	
		
	By:	 	  

	Name:	 	
	Title:	 	


  
 A-6 








 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

This is one of the Notes of the series designated therein referred to in the within-mentioned Indenture, as such is supplemented by the
within-mentioned Second Supplemental Indenture. 
  

			
	DEUTSCHE BANK TRUST COMPANY AMERICAS, as Trustee
		
	By:	 	Deutsche Bank National Trust Company
		
	By:	 	  

	Name:	 	
	Title:	 	


 Dated:
                     

  
 A-7 








 ASSIGNMENT FORM 

I or we assign and transfer this Note to 
  

	
	  

	
	  

	(Print or type name, address and zip code of assignee or transferee)
	
	  

	(Insert Social Security or other identifying number of assignee or transferee)

 and irrevocably appoint
                     as agent to transfer this Note on the books of the Company. The agent may substitute another to act for him. 

 

							
	Dated:                     	 		 	Signed:	 	  

		 		 	(Sign exactly as name appears on the other side of this Note)
			
	Signature Guarantee:	 		 	  
 Participant in a recognized Signature
Guarantee Medallion Program (or other signature guarantor program reasonably acceptable to the Trustee)

				
	Dated:                     	 		 	Signed:	 	  

		 		 	 (Sign exactly as name appears on the other side of this Note)

			
	Signature Guarantee:	 		 	  
 Participant in a recognized Signature
Guarantee Medallion Program (or other signature guarantor program reasonably acceptable to the Trustee)



  
 A-8 








 [Attach to Global Note only] 

SCHEDULE OF INCREASES AND DECREASES IN GLOBAL NOTE 

Zoetis Inc. 
 3.450% Senior Note
due 2020 
 The initial principal amount of this Global Note is $500,000,000. The following increases or decreases in this Global Note have been made: 

 

									
	 Date
	 	 Amount of

decrease in

Principal

Amount of this

Global Note
	 	 Amount of

increase in

Principal

Amount of this

Global Note
	 	 Principal

Amount of this

Global Note
 following
such
 decrease or

increase
	 	 Signature of

authorized
 signatory
of
 Trustee or Note

Custodian

		 		 		 		 	
		 		 		 		 	
		 		 		 		 	


  
 A-9 








 EXHIBIT B 

Form of 4.500% Senior Note due 2025 

ZOETIS INC. 
 4.500%
Senior Note due 2025 
 PRINCIPAL AMOUNT 
  

			
	No.                     	  	$[●]
		
	CUSIP:                     	  	
	ISIN:                     	  	

 Zoetis Inc., a Delaware corporation (herein called the “Company,” which term includes any
successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede &Co., or registered assigns, the principal sum of $[●], or such greater or lesser amount set forth in the attached Schedule
of Increases and Decreases in Global Note on November 13, 2025 (the “Maturity Date”) (except to the extent redeemed or repaid prior to the Maturity Date) and to pay interest thereon from November 13, 2015 (the
“Original Issue Date”) or from the most recent Interest Payment Date to which interest has been paid or duly provided for semi-annually at the rate of 4.500% per annum, on May 13 and November 13 (each such date, an
“Interest Payment Date”), commencing May 13, 2015, until the principal hereof is paid or made available for payment. 

Payment of Interest. The interest so payable, and punctually paid or made available for payment, by 10:00 a.m. New York time, on any
Interest Payment Date, will, as provided in the Indenture (defined below), be paid, in immediately available funds, to the Person in whose name this Note (or one or more predecessor securities) is registered at the close of business on the
April 28 or October 29 (whether or not a Business Day, as defined in the Indenture), as the case may be, next preceding such Interest Payment Date (the “Regular Record Date”). Any such interest not punctually paid or duly
provided for (“Defaulted Interest”) will forthwith cease to be payable to the Holder on such Regular Record Date, and such Defaulted Interest, may be paid to the Person in whose name this Note (or one or more predecessor securities)
is registered at the close of business on a special record date (the “Special Record Date”) for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Notes not less than ten
days prior to such Special Record Date, or may be paid at any time in any other lawful manner not inconsistent with requirements of any securities exchange on which the Notes may be listed, and upon such notice as may be required by such exchange,
all as more fully provided in said Indenture. 
 Place of Payment. Payment of principal, premium, if any, and interest on this Note
will be made at the Corporate Trust Office of the Trustee or such other office or agency of the Company as may be designated for such purpose, in such currency of the United States of America as at the time of payment is legal tender for payment of
public and private debts; provided, however, that each installment of interest, premium, if any, and principal on this Note may at the Company’s option be paid in immediately available funds by transfer to an account maintained by the
payee located in the United States of America. 

  
 B-1 








 Time of Payment. In any case where any Interest Payment Date, the Maturity Date or any
date fixed for redemption or repayment of the Notes shall not be a Business Day, then (notwithstanding any other provision of the Indenture or this Note), payment of principal or interest, if any, need not be made on such date, but may be made on
the next succeeding Business Day with the same force and effect as if made on such Interest Payment Date, the Maturity Date or the date so fixed for redemption or repayment, and no interest shall accrue in respect of the delay. 

General. This Note is one of a duly authorized issue of Securities of the Company, issued and to be issued in one or more series under
an indenture (the “Base Indenture”), dated as of January 28, 2013, between the Company and Deutsche Bank Trust Company Americas (herein called the “Trustee,” which term includes any successor Trustee under the
Indenture with respect to a series of which this Note is a part), as supplemented by a Second Supplemental Indenture thereto, dated as of November 13, 2015 (the “Second Supplemental Indenture” and, together with the Base
Indenture, the “Indenture”), among the Company and the Trustee. Reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee
and the Holders of the Securities, and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Note is one of a duly authorized series of Securities designated as “4.500% Senior Notes due 2025”
(collectively, the “Notes”), initially limited in aggregate principal amount to $750,000,000. 
 Further Issuance.
The Company may from time to time, without the consent of the Holders of the Notes, issue additional Securities (the “Additional Securities”) of this series having the same ranking and the same interest rate, maturity and other
terms as the Notes. Any Additional Securities of this series and the Notes will constitute a single series under the Indenture and all references to the Notes shall include the Additional Securities unless the context otherwise requires;
provided that no Event of Default with respect to the Notes shall have occurred and be continuing; provided further that if any such Additional Securities are not fungible with the Notes for U.S. federal income tax purposes, such
Additional Securities shall have a separate CUSIP number and shall not constitute a single series with such Notes. 
 Events of
Default. If an Event of Default with respect to the Notes shall have occurred and be continuing, the principal of the Notes may be declared due and payable in the manner and with the effect provided in the Indenture. 

Sinking Fund. The Notes are not subject to any sinking fund. 

Optional Redemption. The Notes will be redeemable at any time, at the option of the Company, in whole or from time to time in part,
upon not less than 30 nor more than 60 days’ prior notice, on any date prior to their Maturity at a redemption price, calculated pursuant to the Indenture, which includes accrued interest thereon, if any, to, but excluding, the Redemption Date.
In the case of any partial redemption, selection of the Notes for redemption will be made by the Trustee in accordance with the procedures of DTC. If any Note is to be redeemed in part 

  
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only, the notice of redemption relating to such Note shall state the portion of the principal amount thereof to be redeemed; provided that the principal amount of any Note remaining
outstanding after a redemption in part shall be $2,000 or a higher integral multiple of $1,000. A new Note in principal amount equal to the unredeemed portion thereof will be issued in the name of the Holder thereof upon cancellation of this Note.

 Repurchase upon a Change of Control Triggering Event. Upon the occurrence of a Change of Control Triggering Event with respect to
the Notes, the Company shall be required to make an offer to repurchase the Notes on the terms set forth in the Indenture. 
 Restrictive
Covenants. The Indenture contains certain covenants that, among other things, limit the ability of the Company and its Subsidiaries to create liens or the ability of the Company to consolidate, merge or sell, transfer or lease all or
substantially all of its assets. 
 Defeasance and Covenant Defeasance. The Indenture contains provisions for defeasance at any time
of (a) the entire indebtedness of the Company on this Note and (b) certain restrictive covenants and the related Defaults and Events of Default, upon compliance by the Company with certain conditions set forth therein, which provisions
apply to this Note. 
 Modification and Waivers; Obligations of the Company Absolute. The Indenture permits, with certain exceptions
as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series. Such amendment may be effected under the Indenture at any time by the
Company, and the Trustee with the consent of the Holders of not less than a majority in aggregate principal amount of the outstanding Notes of each series affected thereby. The Indenture also contains provisions permitting the Holders of not less
than a majority in aggregate principal amount of the Securities at the time outstanding, on behalf of the Holders of all outstanding Securities, to waive compliance by the Company with certain provisions of the Indenture. Furthermore, provisions in
the Indenture permit the Holders of not less than a majority in aggregate principal amount of the outstanding Securities of individual series to waive on behalf of all of the Holders of Securities of such individual series certain past defaults
under the Indenture and their consequences. Any such consent or waiver shall be conclusive and binding upon the Holder of this Note and upon all future Holders of this Note and of any Note issued upon the registration of transfer hereof or in
exchange hereof or in lieu hereof, whether or not notation of such consent or waiver is made upon this Note. 
 No reference herein to the
Indenture and no provision of this Note or of the Indenture shall alter or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of and interest on this Note at the time, place, and rate, and in the
currency, herein prescribed. 
 No Recourse Against Others. No director, officer, agent, employee, incorporator, stockholder,
partner, member, or manager of the Company shall have any liability for any obligations of the Company under any Notes or the Indenture or for any claim based on, in respect of, or by reason of, such obligations or their creation. Each Holder of the
Notes by accepting a Note waives and releases all such liability. The waiver and release are part of the consideration for issuance of the Notes. 

  
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 Limitation on Suits. As set forth in, and subject to, the provisions of the Indenture, no
Holder of any Note will have any right to institute any proceeding with respect to the Indenture or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice of a continuing Event of Default with respect
to this series, the Holders of not less than 33% in principal amount of the outstanding Notes shall have made written request, and offered indemnity satisfactory to the Trustee, to the Trustee to institute such proceedings as Trustee, and the
Trustee shall not have received from the Holders of a majority in principal amount of the outstanding Notes a direction inconsistent with such request and shall have failed to institute such proceeding within 60 days; provided, however, that
such limitations do not apply to a suit instituted by the Holder hereof for the enforcement of payment of the principal of or interest on this Note on or after the respective due dates expressed herein. 

Authorized Denominations. The Notes are issuable only in registered form without coupons in minimum denominations of $2,000 and
integral multiples of $1,000 in excess thereof. 
 Registration of Transfer or Exchange. As provided in the Indenture and subject to
certain limitations herein and therein set forth, the transfer of this Note is registrable in the register of the Notes maintained by the Security Registrar upon surrender of this Note for registration of transfer, at the office or agency of the
Company in any place where the principal of and interest on this Note are payable, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company and the Security Registrar, duly executed by the Holder
hereof or his attorney duly authorized in writing, and thereupon one or more new Notes, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

As provided in the Indenture and subject to certain limitations herein and therein set forth, the Notes are exchangeable for a like aggregate
principal amount of Notes of different authorized denominations, as requested by the Holders surrendering the same. 
 No service charge
shall be made for any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Note for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee may
treat the Holder as the owner hereof for all purposes (except with respect to certain payments of Defaulted Interest), whether or not this Note be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the
contrary. 
 Defined Terms. All terms used in this Note, which are defined in the Indenture and are not otherwise defined herein,
shall have the meanings assigned to them in the Indenture. 
 Governing Law. This Note shall be governed by and construed in
accordance with the laws of the State of New York. 
 Unless the certificate of authentication hereon has been executed by the Trustee by
manual signature, this Note shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

  
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 [Remainder of page intentionally left blank] 

  
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 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

Dated:                      

 

			
	ZOETIS INC., as the Company
		
	By:	 	  

	Name:	 	
	Title:	 	


  

			
	Attest:	 	
		
	By:	 	  

	Name:	 	
	Title:	 	


  
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 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

This is one of the Notes of the series designated therein referred to in the within-mentioned Indenture, as such is supplemented by the
within-mentioned Second Supplemental Indenture. 
  

			
	DEUTSCHE BANK TRUST COMPANY AMERICAS, as Trustee
		
	By:	 	Deutsche Bank National Trust Company
		
	By:	 	  

	Name:	 	
	Title:	 	


 Dated:
                     

  
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 ASSIGNMENT FORM 

I or we assign and transfer this Note to 
  

	
	  

	
	  

	(Print or type name, address and zip code of assignee or transferee)
	
	  

	(Insert Social Security or other identifying number of assignee or transferee)

 and irrevocably appoint
                     as agent to transfer this Note on the books of the Company. The agent may substitute another to act for him. 

 

							
	Dated:                     	 		 	Signed:	 	  

		 		 	(Sign exactly as name appears on the other side of this Note)
			
	Signature Guarantee:	 		 	  
 Participant in a recognized Signature
Guarantee Medallion Program (or other signature guarantor program reasonably acceptable to the Trustee)

				
	Dated:                     	 		 	Signed:	 	  

		 		 	(Sign exactly as name appears on the other side of this Note)
			
	Signature Guarantee:	 		 	  
 Participant in a recognized Signature
Guarantee Medallion Program (or other signature guarantor program reasonably acceptable to the Trustee)



  
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 [Attach to Global Note only] 

SCHEDULE OF INCREASES AND DECREASES IN GLOBAL NOTE 

Zoetis Inc. 
 4.500% Senior Note
due 2025 
 The initial principal amount of this Global Note is $750,000,000. The following increases or decreases in this Global Note have
been made: 
  

									
	 Date
	 	 Amount of

decrease in

Principal

Amount of this

Global Note
	 	 Amount of

increase in

Principal

Amount of this

Global Note
	 	 Principal

Amount of this

Global Note
 following
such
 decrease or

increase
	 	 Signature of

authorized
 signatory
of
 Trustee or Note

Custodian

		 		 		 		 	
		 		 		 		 	
		 		 		 		 	


  
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 EXHIBIT C 

DTC LEGEND 
 UNLESS THIS
CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS
REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF
DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS A BENEFICIAL INTEREST HEREIN. 

TRANSFERS OF THIS GLOBAL NOTE ARE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO NOMINEES OF CEDE & CO. OR TO A SUCCESSOR THEREOF
OR SUCH SUCCESSOR’S NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL NOTE ARE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE TRANSFER PROVISIONS OF THE INDENTURE. 

  
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