**EXHIBIT 31.1**

 

**CERTIFICATION PURSUANT TO SECTION 302**

**OF THE SARBANES-OXLEY ACT OF 2002**

 

I, Stanislaw R. Burzynski,certify that:

 

1.                                       I have reviewedthis annual report on Form 10-K of Burzynski Research Institute, Inc.(“BRI”);

 

2.                                       Based on myknowledge, this report does not contain any untrue statement of a material factor omit to state a material fact necessary to make the statements made, inlight of the circumstances under which such statements were made, notmisleading with respect to the period covered by this report;

 

3.                                       Based on myknowledge, the financial statements, and other financial information includedin this report, fairly present in all material respects the financialcondition, results of operations and cash flows of BRI as of, and for, theperiods presented in this report;

 

4.                                       I amresponsible for establishing and maintaining disclosure controls and procedures(as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) andinternal controls over financial reporting (as defined in Exchange Act Rules 13a-15(f) and15d15(f) for BRI and have:

 

### **(a)**                                  Designed such disclosure controls andprocedures, or caused such disclosure controls and procedures to be designedunder my supervision, to ensure that material information relating to BRI, ismade known to me by others within those entities, particularly during theperiod in which this report is being prepared;

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### **(b)**                                 Designed such internal control over financialreporting, or caused such internal control over financial reporting to bedesigned under my supervision, to provide reasonable assurance regarding thereliability of financial reporting and the preparation of financial statementsfor external purposes in accordance with generally accepted accountingprinciples;

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### **(c)**                                  Evaluated the effectiveness of BRI’sdisclosure controls and procedures and presented in this report my conclusionsabout the effectiveness of the disclosure controls and procedures, as of theend of the period covered by this report based on such evaluation; and

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### **(d)**                                 Disclosed in this report any change in BRI’sinternal control over financial reporting that occurred during BRI’s mostrecent fiscal quarter (BRI’s fourth fiscal quarter in the case of an annualreport) that has materially affected, or is reasonably likely to materially affect,BRI’s internal control over financial reporting;

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5.                                       I havedisclosed, based on my most recent evaluation of internal control overfinancial reporting, to BRI’s auditors and BRI’s board of directors (or personsperforming the equivalent functions of an audit committee):

 

### **(a)**                                  All significant deficiencies and materialweaknesses in the design or operation of internal control over financialreporting which are reasonably likely to adversely affect BRI’sability to record, process, summarize andreport financial information; and

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### **(b)**                                 Any fraud, whether or not material, thatinvolves management or other employees who have a significant role in BRI’sinternal control over financial reporting.

 

 
| Date: June 1, 2010 | /s/ Stanislaw R. Burzynski           |
|-------------------------|--------------------------------------|
|                    | Stanislaw R. Burzynski,              |
|                    | President, Secretary, Treasurer, and |
|                    | Chairman of the Board of Directors   |
|                    | (Chief Executive Officer and         |
|                    | Principal Financial Officer)         |

 

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