| Massachusetts                                       | 001-33898                  | 20-4652200               |
|-----------------------------------------------------|----------------------------|--------------------------|
| (State      or Other Jurisdiction)                  | (Commission      File No.) | (I.R.S.      Employer    |
| of      Incorporation)                              |                       | Identification      No.) |
|                                                |                       |                     |
|                                                |                       |                     |
| 10 Meridian Street,      East Boston, Massachusetts |                       | 02128                    |
| (Address      of Principal Executive Offices)       |                       | (Zip      Code)          |

| o | Written      communications pursuant to Rule 425 under the Securities Act (17 CFR      230.425) |
|---|-------------------------------------------------------------------------------------------------|

| o | Soliciting      material pursuant to Rule 14a-12 under the Exchange Act (17 CFR      240.14a-12) |
|---|--------------------------------------------------------------------------------------------------|

| o | Pre-commencement      communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR      240.14d-2(b)) |
|---|------------------------------------------------------------------------------------------------------------------|

| o | Pre-commencement      communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR      240.13e-4(c)) |
|---|------------------------------------------------------------------------------------------------------------------|

----

| Item      2.02 | Results of Operations      and Financial Condition |
|----------------|----------------------------------------------------|

| Item      9.01. | Financial Statements      and Exhibits. |
|-----------------|-----------------------------------------|

|   | (a) | Not      Applicable. |
|--------|-----|----------------------|

|   | (b) | Not      Applicable. |
|--------|-----|----------------------|

|   | (c) | Not      Applicable. |
|--------|-----|----------------------|

|   | (d) | Exhibits. |
|--------|-----|-----------|

|   | Exhibit      No.           |                        Exhibit |
|--------|----------------------------|---------------------------------------------------------------------------------------------------------------------|
|   |                       |                                                                                                                |
|   |     99 | Press      release dated May 5, 2008                                                                                |

----

|                   |   | MERIDIAN      INTERSTATE BANCORP, INC.     |
|------------------------|--------|--------------------------------------------|
|                   |   |                                       |
|                   |   |                                       |
|                   |   |                                       |
| DATE:      May 7, 2008 | By:    | /s/      Leonard V. Siuda                  |
|                   |   | Leonard      V. Siuda                      |
|                   |   | Treasurer      and Chief Financial Officer |