**EXHIBIT 31.1**

 

**CERTIFICATION PURSUANT TO SECTION 302**

**OF THE SARBANES-OXLEY ACT OF 2002**

 

I, Stanislaw R. Burzynski,certify that:

 

1.                                       I have reviewedthis annual report on Form 10-K of Burzynski Research Institute, Inc.(“BRI”);

 

2.                                       Based on myknowledge, this report does not contain any untrue statement of a material factor omit to state a material fact necessary to make the statements made, inlight of the circumstances under which such statements were made, notmisleading with respect to the period covered by this report;

 

3.                                       Based on myknowledge, the financial statements, and other financial information includedin this report, fairly present in all material respects the financialcondition, results of operations and cash flows of BRI as of, and for, theperiods presented in this report;

 

4.                                       I amresponsible for establishing and maintaining disclosure controls and procedures(as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) andinternal control over financial reporting (as defined in Exchange Act Rules13a-15(f) and 15d-15(f)) for BRI and have:

 

### **(a)**                                  Designed such disclosure controls andprocedures, or caused such disclosure controls and procedures to be designedunder my supervision, to ensure that material information relating to BRI,including its consolidated subsidiaries, is made known to me by others withinthose entities, particularly during the period in which this report is beingprepared;

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### **(b)**                                 Designated such internal control over financial reporting, or caused suchinternal control over financial reporting to be designated under mysupervision, to provide reasonable assurance regarding the reliability offinancial reporting and the preparation of financial statements for externalpurposes in accordance with generally accepted accounting principles;

 

### **(c)**                                  Evaluated the effectiveness of BRI’sdisclosure controls and procedures and presented in this report my conclusionsabout the effectiveness of the disclosure controls and procedures, as of theend of the period covered by this report based on such evaluation; and

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### **(d)**                                 Disclosed in this report any change in BRI’sinternal control over financial reporting that occurred during BRI’s mostrecent fiscal quarter (BRI’s fourth fiscal quarter in the case of an annualreport) that has materially affected, or is reasonably likely to materiallyaffect, BRI’s internal control over financial reporting; and

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5.                                       I havedisclosed, based on my most recent evaluation of internal control overfinancial reporting, to BRI’s auditors and BRI’s board of directors (or personsperforming the equivalent functions of an audit committee):

 

### **(a)**                                  All significant deficiencies and materialweaknesses in the design or operation of internal control over financialreporting which are reasonably likely to adversely affect BRI’sability to record, process, summarize andreport financial information; and

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### **(b)**                                 Any fraud, whether or not material, thatinvolves management or other employees who have a significant role in BRI’sinternal control over financial reporting.

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| Date: May 29, 2009 | /s/ Stanislaw R. Burzynski           |
|-------------------------|--------------------------------------|
|                    | Stanislaw R. Burzynski,              |
|                    | President, Secretary, Treasurer, and |
|                    | Chairman of the Board of Directors   |
|                    | (Chief Executive Officer and         |
|                    | Principal Financial Officer)         |

 

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