**EXHIBIT 31.1**

**CERTIFICATIONPURSUANT TO SECTION 302**

**OF THE SARBANES-OXLEY ACT OF 2002**

I, Stanislaw R. Burzynski,certify that:

1.             I have reviewed this annual report on Form10-KSB of Burzynski Research Institute, Inc. (“BRI”);

2.             Based on my knowledge, this report does notcontain any untrue statement of a material fact or omit to state a materialfact necessary to make the statements made, in light of the circumstances underwhich such statements were made, not misleading with respect to the periodcovered by this report;

3.             Based on my knowledge, the financialstatements, and other financial information included in this report, fairlypresent in all material respects the financial condition, results of operationsand cash flows of BRI as of, and for, the periods presented in this report;

4.             I am responsible for establishing andmaintaining disclosure controls and procedures (as defined in Exchange ActRules 13a-15(e) and 15d-15(e)) for BRI and have:

### (a)           Designed such disclosure controls andprocedures, or caused such disclosure controls and procedures to be designedunder my supervision, to ensure that material information relating to BRI,including its consolidated subsidiaries, is made known to me by others withinthose entities, particularly during the period in which this report is beingprepared;

### (b)           Evaluated the effectiveness of BRI’sdisclosure controls and procedures and presented in this report my conclusionsabout the effectiveness of the disclosure controls and procedures, as of theend of the period covered by this report based on such evaluation; and

### (c)           Disclosed in this report any change in BRI’sinternal control over financial reporting that occurred during BRI’s mostrecent fiscal quarter (BRI’s fourth fiscal quarter in the case of an annual report)that has materially affected, or is reasonably likely to materially affect, BRI’sinternal control over financial reporting;

5.             I have disclosed, based on my most recentevaluation of internal control over financial reporting, to BRI’s auditors and BRI’sboard of directors (or persons performing the equivalent functions of an auditcommittee):

### (a)           All significant deficiencies and materialweaknesses in the design or operation of internal control over financialreporting which are reasonably likely to adversely affect BRI’s ability torecord, process, summarize and report financial information; and

### (b)           Any fraud, whether or not material, thatinvolves management or other employees who have a significant role in BRI’sinternal control over financial reporting.

| Date:  May 29,  2007 |   | /s/ Stanislaw R. Burzynski            |
|--------------------------------|--------|---------------------------------------|
|                           |   | Stanislaw R.  Burzynski,              |
|                           |   | President,  Secretary, Treasurer, and |
|                           |   | Chairman of the  Board of Directors   |
|                           |   | (Chief Executive  Officer and         |
|                           |   | Principal  Financial Officer)         |

 

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