### AGENDA

**U .**  **S .**  **ENVIRONMENTAL PROTECTION AGENCY (EPA) FIFRA SCIENTIFIC ADVISORY PANEL (SAP)** 

**OPEN MEETING JULY 29**  **- JULY 3**  **1, 2014 FIFRA SAP WEB SITE http://www.epa.gov/scipoly/sap/**  **D OCKET**  **N UMBER**  **: EPA** 

**– HQ** 

**– OPP** 

**– 2014** 

**– 0331**  **U.S. E NVIRONMENTAL PROTECTION AGENCY**  **C ONFERENCE**  **C ENTER**  **L OBBY**  **L EVEL**  **O NE POTOMAC**  **Y ARD**  **( SOUTH**  **B LDG.**  **) 2777 S. C**  **RYSTAL DRIVE , A** **RLINGTON , VA 22202**  **Scientific Issues**  **Associated with New** **High Throughput Methods**

**To Estimate Chemical Exposure**  **Please note that all times are approximate (see note at the**  **end of the**  **Agenda) .**  **Day 1 Tuesday**  **, July 29, 2014**  **9 :00**  **A .M. Opening of Meeting and Administrative Procedures**  **--** Fred Jenkins , Ph.D. , Designated Federal Official, Office of Science Coordination and Policy , EPA **9 :05**  **A .M. Introduction and Identification of Panel Members**  **--** James Mc M anaman , Ph.D. , FIFRA Scientific Advisory Panel Session Chair **9 :1**  **0 A**  **.M. Welcome and**  **Opening Remarks**

– David Dix, Ph.D., Director, Office of Science Coordination and Policy (OSCP) , EPA **9 :**  **20 A**  **.M. Introduction and Overview:**  **New High Throughput Methods to Estimate Chemical Exposure**  **--** A lan Dixon, Exposure Assessment Coordination and Policy Division (EACPD , OSCP ) , EPA **Exposure Prioritization with ExpoCast Research 10**  **: 0**  **0 A.M.**  **A Framework for High Throughput Exposure (HTE) Estimation --**  John Wambaugh, Office of Research and Development (ORD), and National Center for Computational Toxicology (NCCT) , EPA **10:30 A.M. Break 1**  **0 :**  **45 A.M.**  **High Throughput Forward Prediction of Human Exposure --**  Peter P. Egeghy, Ph.D. M.P.H., National Exposure Research Laboratory (NERL) , ORD , EPA**1 1**  **: 0**  **5 A**  **.M. Inference (Reverse Prediction) of Human Exposure**  **--** Woodrow Setzer, National

Center for Computational Toxicology (NCCT), ORD , EPA **1 1**  **: 3**  **5 A**  **.M. Systematic Empirical Evaluation of Models (SEEM) Analysis and High**  **Throughput Exposure Estimates --**  John Wambaugh, ORD, NCCT , EPA **12:00 P.**  **M. Lunch**  **High Throughput Toxicokinetics (HTTK) and Reverse Toxicokinetics (RTK)**  **1:00 P.M. High**  **Throughput Toxicokinetics (HTTK) and Reverse Toxicokinetics (RTK) for**  **the E**  **ndocrine D**  **isruptor S**  **creening P**  **rogram (EDSP) --**  John Wambaugh ORD , NCCT , EPA **Ongoing Research Needs : Ecological Exposure**  **Predictions 2:10 P.M. High Throughput Ecological Exposure Modeling**  **--** Craig Barber, Ph.D. NERL, ORD, EPA **2:35 P.M. Break 2:5**  **0 P.**  **M. Evaluation Data and Statistical Framework for Ecological Exposure Predictions** 

**--** Woodrow Setzer , NCCT, ORD , EPA **Ongoing Research Needs**  **: Near Field Human Exposure Modeling 3:10 P.M. Toward a Third Generation SEEM Analysis: New Data and Models**  **--** Kristin I saacs, Ph.D. NERL , ORD, EPA **Future Applications 3**  **: 50**  **P. M.**  **EDSP Integrated Activity and Exposure Based Prioritization and Screening** 

**–** Steven Knott, Director**,** EACPD , OSCP, EPA **4 :**  **35 P.**  **M. Adjourn Day 2**  **Wednesday, July 30**  **, 2014 9:00 A.M. Opening of Meeting and Administrative Procedures** 

– Fred Jenkins, Ph.D. , Designated Federal Official, Office of Science Coordination and Policy , EPA **9:05 A**  **.M. Introduction and Identification of Panel Members**

– James McManaman , Ph.D., FIFRA Scientific Advisory Panel Session Chair **9:10 A.M. F ollow**  **- up from the**  **P revious**  **Day Presentations 10**  **: 0**  **0 A.M. P ublic Comments**  **1 0**  **: 45**  **A.M .**  **B reak**  **1 1**  **: 0**  **0 A.M. Public Comments**  **(C ont**  **’d )**  **12:00 P.M. L unch**  **1: 00**  **P. M.**  **Charge to Panel Charge Question 1.1.**  Inthe absence of sufficient exposure information to estimate exposure for the majority

of the chemicals of interest in the Endocrine Disruption Screening Program ( EDSP ) using EPA's historical low
- throughput methods, please comment on whether the Systemati c Empirical Evaluation of Models approach ( SEEM ) is scientificall y sound and suitable for using High Throughput Exposure (HTE) methods to estimate relative levels of chemical exposures and the associated uncertainty of these estimates for consideration in a prioritization approach. **2:00 P.M. Charge to Panel Charge Question 1.2**  Please suggest the most important steps for EPA that could decrease uncertainties and increase confidence in using the HTE approach to predict exposures in various demographic groups (e.g., young children, women of child bearing age) for large numbers of chemicals. **2 :**  **45 P**  **. M**  **. B**  **reak 3:**  **00 P**  **. M**  **. C**  **harge to Panel Charge Question 2.1.**  Inthe absence of sufficient empirical toxicokinetics information for the thousands of EDSP relevant chemicals, please comment on the approach of using High Throughput TK (HTTK) , High Throughput PBTK (HTPBTK) , I n Vitro

-In Vivo Extrapolation ( IV IVE ) , and Reverse Toxicokinetics (RTK) for estimating chemical TK to provide anadministered dose context to the concentrations showing bioactivity in the endocrine
- related High
- throughput screening ( HTS ) assays . **4:00 P.M. Charge to Panel Charge Question 2.2.**  A comparison of the HTTK
-predicted steady- state blood concentrations with in vivo values from the literature suggests that the overall correlation is low, but that the discrepancy

between the two can be predicted using a combination of chemical properties, quantitative structure activity relationships (QSAR), and cutoffs from the HTTK assays. Please comment on: a) how well this approach characterizes the uncertainty in the steady
- state blood concentrations, and b) whether the identification of chemical classes that need additional TK investigation is useful in a chemical prioritization or initial screening context. **5: 0**  **0 P .**  **M .**  **A djourn** **Day 3 Thursday**  **, July 3**  **1 , 2014**  **9:00 A.M. Opening of Meeting and Administrative Procedures**

– Fred Jenkins, Ph.D. , Designated Federal Official, Office of Science Coordination and Policy , EPA **9:05 A.M. Introduction and Identification of Panel Members**

– James McManaman , Ph.D., FIFRA Scientific Advisory Panel Session Chair **9:10 A.M. Follow**  **- up from the**  **Previous Day Di scussions**  **9: 2**  **0 A.M. Charge to Panel**  **(Cont’d) Charge Question 2.3.**  Please comment on whether the assumptions made in these models are appropriate given the current state of the science and data limitations. **10: 00**  **A.M. Charge to Panel**  **Charge Question 2.4.**  Please suggest the most important steps EPA should take to improve the various kinetic models to provide rapid and cost
- effective predictions for large number of chemicals. **1 0**  **: 45**  **A.M. Break**  **1 1**  **: 00**  **A.M. Charge to Panel Charge Question 2.5** 
. Please co mment on the approaches presented in the present White Paper for comparing RTK
- derived endocrine
- active dose ranges with exposure predictions from ExpoCast. Discuss the strengths and limitations of these comparisons, and whether this or other approaches are suitable for clearly distinguishing chemicals with higher predicted doses from chemicals with lower predicted RTK adjusted doses. **1 2**  **: 00**  **P .M.**  **Lunch 1**  **: 00**  **P. M.**  **Charge to Panel (Cont’d)**  **Charge Question 3.1.** Please comment on the three key areas including whether there are other areas that are of equal or higher priority to support an integrated activity /hazard and exposure based prioritization and screening approach within the EDSP or other chemical programs
.**1:45 P.M. Charge to Panel**

**Charge Question 3.2.** We propose appl ying the ExpoCast framework to ecological exposures using aggregated water monitoring data to evaluate the predictions of environmental fate and transport models. Please identify other data, models or environmental media that may be of greater value in the initial model calibration and uncertainty analysis. **2 :**  **30 P.**  **M. B reak**  **2 :**  **45 P.**  **M. Charge to Panel Charge Question 3.3.**  Please identify other relatively

high
- throughput sources of exposure
related information that should be included in these three key areas and suggest how this information would be used to help prioritize chemicals. **3 :**  **45 P.**  **M. Charge to Panel Charge Question 3.4.**  For the HTTK work going forward, please comment on additional studies that could be performed or approaches that could be taken to improve rapid and cost efficient predictions of TK for large numbers of chemicals. **4 :**  **30 P.**  **M. Closing Remarks**

– James McManaman, Ph.D., FIFRA Scientific Advisory Panel Session Chair Fred Jenkins, Ph.D., Designated Federal Official, Office of Science Coordination and Policy, EPA **5: 0**  **0 P.M. A djourn** 

**Note: P**  **lease be advised that agenda times are approximate; when the discussion for one topic is completed, discussions for the next topic will begin. For further information,**  **please contact the Designated Federal Official for this meeting, Dr. Fred Jenkins, via telephone:**  **(202) 564 -** **3327; fax: (202) 564 -**  **8382; or email: jenkins.fred@epa.gov .**