### Pyroxasulfone Dietary E xposure and Ri sk Assessment PC Code: 090099 DP Number : D4 17422



### UNIT ED STATE S E NVIRON M ENTAL PROTECT I ON AGENC Y WASHINGTON , D.C. 20460



### MEMORANDUM

Date: 22-May-2014 O F F I C E OF C H E M ICAL SA FETY AND POLLUTION PREVE NTION



### Subject: Pyroxasulfone. Acute and Chronic Aggregate Dietary Exposure and Risk Assessments for the Amended Section 3 Registration Request for Use of Pyroxasulfone on Corn.

PC Code: 090099 DP Barcode: D417422 Decision No.: 482174 R egistration No.: 63588-91,63588-92 and 63588-93 Petition No .: 3F8196 Regulatory Action: Section 3 Registration Risk Assessment Type: Single Chemical, Dietary Case No.: NA TXR No.: NA CAS No.: 447399-55-5 MRIDNo.: NA 40CFR: 180.659**~** 

### Reviewer: Thurston G. Morton, Chemist

# ~ '),

..

# /~ 0 Risk Assessment Branch IV !Health Effects Division (RABIV/HED; 7509P)
Through: Mohsen Sahafeyan, Chemis

And



### Elissa Reaves, PhD, Chief RABIV/HED (7509P)

To: Bethany Benbow Herbicide Branch/RD (7505P)

# ~-£?-

Page 1 o f 12

### Pyroxasulfone Dietary Exposure and R isk Assessment PC Code: 090099


## Executive Summary DP Number: 0417422



### Acute and chronic aggregate dietary food and drinking water exposure and risk assessments for pyroxasulfone were conducted using the Dietary Exposure Eval ua tion Model software with the Food Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food consumption data from the U.S. Department of Agriculture's (USDA's) National Health and Nutrition Examination Survey, What We Ea t in America, (NHANES/WWEIA). This dietary analysis is updated to reflect the latest consumption data and to support registration review.

This memorandum was reviewed by two peer reviewers ofthe DESAC per the current DESAC Standard Operating Procedure (SOP).
Pyroxasulfone is proposed for an amended use on corn. Unrefined acute and chronic aggregate (food and water) assessments were conducted using tolerance level residues adjusted for metabolites along with 100 % crop treated (CT).

The resulting aggregate (food and water) acute exposure estimates were less than HED ' s level of
concern (<100% acute Population Adjusted Dose (aPAD)) for general U.S. population (1.2% aPAD) and all population sub-groups; the mosthighly exposed population subgroup was A ll Infants
< 1 year old with 3.6% aPAD at the 95 1 h 

### percentile.

The resulting aggregate (food and water) chronic exposure estimates were less than HED 's level of
concern (< 1 00% cPAD) for general U.S. population ( 19% cPAD) and all population sub-groups ; the most highly exposed population subgroup was All Infants < 1 year old with 48% cPAD.



### I. Introduction
Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage ofa maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This do se is referred to as the population adjusted dose (PAD). The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% ofthe PAD. HED is generally concerned when estimated cancer risk exceeds one in one million. References which di scuss the acute and chronic risk assessments in more detail
are available on the EP N pesticides web site: "Ava ilable Information on Assessing Exposure from Pesticides , A User's Guide," 21-JUN-2000, web link: http: //www.epa.gov/fedrgstr/EPAPEST /2000/July/Day-12/606l.pdf ; or see SOP 99.6 (20-AUG-1999).
Pyroxasulfone 's most recent dietary risk assessment was conducted by T. Morton , D406657, 1/30/13.

Page 2 of 12Pyroxasulfone Dietary Exposure and Risk Assessment PC Code: 090099



### II. Residue Inf ormation DP Number: D417422



### The registrant (K-1 Chemica l, U.S.A. Inc.) has submitted a petition to register pyroxasulfone for an amended use on corn. The existing tolerances are listed in 40 CFR §180.659.

Com, grain 0.020 ppm tolerance plus 0.01 ppm for two metabolites not in the tolerance expression Soybea n , seed 0.06 ppm tolerance plus 0.005 ppm for one metabolite not 

### in the tolerance expression Cotton, undelinted seed 0.04 ppm tolerance plus 0.03 ppm for three metabolites not in the expression M ilk 0.003 ppm tolerance plus 0.002 ppm for two metabolites not in the expression Wheat, grain 0.03 ppm tolerance plus 0.02 ppm for two metabolites not in the expression


### Residues of concern are summarized in the table below (G. Kramer, D379930, 7/30/2010):

Table 1. Compounds to be Included in the Risk Assessment and Tolerance Expression.
Residue s included in Tolerance

Expression for Compliance Matrix Residues included in Risk Assessment Monitoring
Plants Cereal Grains Pyroxasulfone, Ml, M3, M25 Pyroxasulfone, Ml, M3, M25*** Soybeans Pyroxasulfone, Ml , M3, M25 , M28** Pyroxasulfone, M1, M3, M25 , M28* Livestock Pyroxasulfone, M 1, M3 Pyroxasulfone , M1 , M3, M25 , M28 Drinking Water Pyroxasulfone , M I, M3 Not Applicable Pyroxasulfone = 3 -[[[5-(difluoromethoxy )-!-methyl-3-(trifluoromethyl)

- 1 H-pyrazol-4-yl]methyl]sulfonyl]-4,5

- dihydro

- 5,5

- dimethylisoxazole

. M 1 = [5-( difluoromethoxy)-1-methyl-3-(trifluoromethyl)-lH-pyrazol-4-yl) ]methanesulfonic acid. M3 = 5-(difluoromethoxy)-1-methyl-3

- (trifluoromethyl)-lH-pyrazole-4-carboxylic acid. M25 = [5

-( difluoromethoxy)

- 3

-(trifluoromethyl)-1 H-pyrazol-4-yl)]methanesulfonic acid

. M28 = 3-[1-carboxy-2-(5,5-dimethyl-4,5-dihydroisoxazol-3-ylthio )ethylamino ] -3-oxopropanoic acid. Metabolite C = 3

- [ 1-carboxy

-2-(5,5-dimethyl-4,5-dihydroisoxazol

- 3-ylthio )ethenylamino]-3-oxopropanoic acid. *reanalysis ofthe seed samples showed residues of M28 and therefore M28 needs to be included in both the tolerance expression and risk assessment as a residue of concern in soybean seed. M- 

### i is included for soybean forage and hay

. ** residues of concern for soybean seed is pyroxasulfone and metabolite M-1, M-3, M-25 , 

### & M-28 for risk assessment and does not include M

- 1 for tolerance enforcement purposes. ***residues ofconcern for wheat grain, cotton seed, com, field, grain and com, sweet, kernel plus cob with husks removed is pyroxasulfone and metabolite M-3. 

## III. Percent Crop Treated Information

The acute and chronic dietary exposure analyses used 100 

### % crop treated.

Page 3 of 12

### Pyroxasulfone Dietary Exposure and Risk Assessment PC Code: 090099



## IV. Drinking Water Data DP Number: 0417422



### The drinking water estimates used in the dietary risk assessment were provided by the Envirorunental Fate and Effects Division (EFED; Memo , J. Hetrick, 1-June-20 ll ; D39022l ). EFED conducted a Tier II PRZM GW drinking water assessment from groundwater sources for pyroxasulfone. Residues of concern for drinking water for risk assessment purposes were parent , Ml , and M3. The estimated drinking water concentrations (EDWCs) for peak concentration (used in the acute assessment) and average (used in the chronic assessment) were 0.210 and 0.174 mg/L (ppm), respectively.

V. DEEM-FCIDTM Program and Consumption Information
Pyroxasulfone acute and chronic dietary exposure assessments were conducted using the DEEMFCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA's NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days. Foods "as consumed " (e.g., apple pie) are linked to EPA-defined food commodities (e.g. , apples, peeled fruit- cooked; fresh or N/S; baked;
or wheat flour

- cooked; fresh or N/S , baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data
are averaged for the entire U.S. population and within population subgroups. However, for acute
exposure assessment, consumption data are retained as individual consumption events. Based on analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns and survey respondents , HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants ( < 1 year old), children 1- 2 , children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years old.

For a chronic dietary exposure assessment, an estimate ofthe residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form i s summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mglkg body weight/day and as a percent of the cP AD. This procedure is performed for each population subgroup.

For an acute exposure assessment, individual one-day food consumption data are used on an ind ividual-by- individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate and surruned to obta in a total daily pesticide exposure for a deterministic exposure assessment, or " matched " in multiple random pairings with residue values
Page 4 

### of 12

### Pyroxasulfone Dietary Exposure and Risk Assessment PC Code: 090099 DP Number : D417422



### and then summed in a probabi listic assessment. The resulting distribution of exposures is expressed as a percentage ofthe aPAD on both a user (i.e., only those who reported eating relevant commodities/f ood forms) and a per-capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for analyses performed at all levels ofrefmement. However, for deterministic assessments, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.



## VI. T oxicological Information

The toxicological doses and endpoints for pyroxasulfone for use in the dietary assessment are summarized in Table 2.

Table 2. Toxicological Doses and Endpoints for Pyroxasulfone for Use in Dietary Human Health Risk Assessments Exposure/ Point of Uncertai nty / Scenario Departure FQPA Safety RID&PAD Study and Toxicological Effects Factors Acute Dietary NOAEL= 100 UFA= 10 X 

### Acute RID= Developmental neurotoxicity study (DNT) in (General mglkg UFH= IO X 

### 1.0 mglkg rats, MRID 47701724

. Population, FQPA SF= Ix The LOAEL of300 mglkg/day is based on including Infants aPAD = 1.0 decreased brain weight in both sexes, reduc ed and Children) mglkg thickness ofthe hippocampus , corpus callosum and cerebellum in PND 21 female offspring. Chronic Dietary NOAEL= 2 UFA= 10 X 

### Chronic RID One- year chronic dog study, MRID 47701707 (All Populations) mg!kg/day UFH= IO X 

### = 0.02 The LOAEL of I0 mglkg/day is based on FQPA SF= lx mg!kg/day impaired hind limb function, ataxia, hind limb twitching and tremors; clinical pathology: cPAD = 0

. 02 increased creatine kinase, aspartate mglkg/day aminotransferase; axonaVmyelin degeneration of the sciatic nerve and spinal cord sections. Cancer (all routes) "Not Likely to be Carcinogenic to Humans" at dose s that do not cause crystals with subsequent calculi formation resulting 

### in cellular damage ofthe urinary tract. Risk is quantified using a non
-linear (i.e

. , RID) approach

. Point of Departure (POD)= A data pomt or an esttmated point that IS denved from observed dose-response data and used to mark the beginning of extrapolation to determine risk associated with l ower environmentally relevant human exposures. NOAEL

= no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation fro m animal to human (interspecies)

. UFH = potential variation in sensiti vity among members ofthe human population (intraspecies). FQPA SF= FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RID= reference dose. MOE = margin of exposure. N/A = not applicable.


## VII

. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The following summarizes the DEEM-FCIDTM (ver. 3.16) chronic exposure analyses.

Page 

### 5 of 12

### Pyroxasulfone Dietary Exposure and Risk Assessment PC Code: 090099 DP Number: 0417422



### Acute and chronic aggregate (food+ water) analyses were performed us ing DEEM-FCIDTM estimating the dietary expo sure ofthe U.S

. population and various population subgroups. The results are summarized in T able 2.

The resulting aggregate (food and water) acute exposure estimates were less than HED 's level of
concern (<100% acute Population Ad justed Dose (aPAD)) for general U .S. population ( 1. 2% aPAD) and all population sub-groups; the most highly exposed population subgroup was All Infants
< 1 year old with 3.6% aPAD at the 95 1h 

### percentile.

The resulting aggregate (food and water) chronic exposure estimates were less than HED 's level of
concern (< 1 00% cPAD) for general U.S

. population (19% cP AD) and 

### all population sub-groups ; th e most highly exposed population subgroup was All Infants <1 year old with 48% cPAD.

Table 2. R f 

### esults o Acute and Cbronic 

### D E I

.**~** 

### p ietary xposure Ana ys1s or •yroxasu**I~** 

### e (Food and Water) on Acute Dietary Chronic Dietary (95th Percentile) Population Subgroup Dietary Dietary Exposure o/oaPAD Exposure o/ocPAD (mg/kglday) (mglkg/day)
General U.S. Population 0.011740 1.2 0.003822 19

All Infants(< 1 year old) 0.036394 3.6 0.009679 48

Children 1-2 years old 0.018442 1.8 0.005829 29

Children 3-5 years old 0.015013 1.5 

### 0.004898 25

Children 6-12 years old 0.011445 l.l 

### 0.003509 18

Youth 13-19 years old 0.009849 1.0 0 .002843 14

Adults 20-49 years old 0.011476 1.2 0.003774 19

Adults 50-99 years old 0.010239 1.0 0.003700 19

Females 13-49 years old 0.011621 1.2 0.003757 19



## VIII. Characterization of Inputs/Outputs

HED has conducted a conservative assessment for the a mended use ofpyroxa sulfone on com. Tolerance leve l re sidue s along with 100% CT were u sed in the acute and chronic dietary exposure assessments. In addition, DEEM default processing facto r of 1.5x was used for com syrup. Residues do not warrant the need for further refinement at this time.

Page 6 of 12

### Pyroxasulfone Dietary Exposure and Risk Assessment PC Code: 090099


### IX. Conclusions DP Number: 0417422



### Unrefined acute and chronic aggregate (food+ water) dietary ri sk assessments were conducted for pyroxasulfone using the DEEM-FCIDTM (ver. 3.16) model using tolerance level residues , DEEMTM default processing factor, and 100% CT. The resulting acute aggregate exposure estimate was less than HED's level ofconcern. For the general U.S. population and all population subgroups in the acute analysis all dietary exposure estimates were 

## 9l% aPAD). The resulting chronic aggregate exposure estimate was les s than HED ' s level ofconcern. For the general U.S. population, the cPAD was 19% while the most highly-exposed population subgroups in the chronic analysis was All Infants <1 year old (48% cPAD).



### X. Attachments

List of Attachments: Attachment 1: Residue Information. Attachment 2: Acute Results. Attachment 3: Chronic Results.

cc with all attachments: T

. Morton (RABIV) RDI: M. Sahafeyan and K. Rury- DESAC (20-May-2014); E. Reaves (20-May-2014) Petition Number(s): 3F8196 DP# : 417422 PC Code: 090099

. T. Morton:S10838:PY1 :(703)305-669 1

Page 7 of 12Pyroxasulfone Dietary Exposure and Risk Assessment PC Code: 09009 9


### Attachment 1: Residue Information.

Acute Analysis DP Number: 0417422

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\090099 Pyroxasulf one\Amended Corn 3F8196\ 090099ACUTEFOODANDWATER .R0 8 Chemical : Pyroxasulfone RfD(Chronic): .02 mg/kg bw/day NOEL (Ch ronic) : 0 mg/kg bw/day RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Da te created/last modified: 11-13-2013/12:22:57 Program ver. 3.16, 03-08-d Crop EPA Code Grp Comm odi t y Name Def Res (ppm)
0600347000 6 0600349000 6 0600349001 6 0600350000 6 060035000 1 6 0601349500 6AB 06033480 00 6C 0603348 001 6C 1 50012 0000 1 5 1500120001 15 1500121000 15 1500121001 15 1500122000 15 15001 23000 15 1500123 001 15 1500124000 15 150012400 1 15 1500125000 15 15001 25001 15 1500126000 15 1500127000 15 1500127001 15 150038 1 000 15 150038100 1 15 1500401000 15 1500401001 15 1500402000 15 1500402001 15 1 500 403000 1 5 15 00 404000 1 5 2003128000 20C 2003128001 20C 3600222000 36 360022200 1 36 3600223000 36 3600223001 36 3600224 000 36 360022400 1 36 3600225001 36 8601000000 86A 8602000000 86B Soybea n, seed Soybean, soy mi l k Soyb ean, soy milk-babyfood or in Soybean , oil Soybean, oil-babyfood Soybean, vegetable Soybean, flour Soybean, flour-babyfood Corn, f ield, flour Corn, field , flo ur
- baby food Corn, field, meal Corn, field, meal

- babyfood Corn, field, bran Corn, field, starc h Corn, field, starch

- babyfood Corn, field, syrup Corn , field, syrup
- babyfood Corn, fie ld, o il Corn, field, oil -babyfood Corn, pop Corn, sw eet Corn , sweet-babyfood T r it icale, flour Triticale, flou r -b aby food Wheat, grain Wheat, grain-babyfood Wheat, flou r Wheat, flour -babyf ood Wheat, germ Wheat, bran Cottonseed, oil Cottonseed, oil -babyfood Milk, fat Milk, fat-baby food/infant formu Milk, nonfat sol ids Milk, nonfat sol ids

- baby food/in M

i lk, wa ter M

ilk, wate r-baby f ood/infant form Milk, sugar (lacto s e)-baby food / water, direct, all sources Water, indirect, all sources 0.065000 0.065000 0.065000 0.065000 0.065000 0.065000 0.065000 0.065000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.050000 0.050000 0.050000 0.050000 0.050000 0

. 050000 0.050000 0.050000 0.070000 0.070000 0.005000 0.005000 0.005000 0.005000 0 .0050 00 0.005000 0.005000 0.210000 0.210000

Page 8 of 12 Adj.Factors #1 #2

l. 000 l. 000 1 .000 1.000 l. 000 1. 000 1.000 1.000 1 .000 1. 000 l. 000 1.000 1.000 1.000 1.000 1

. 500 1.5 00 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 l. 000 1.000 l. 000 l. 000 l. 000 1.000 l. 000 1.000 1. 000 1.000 1.000 1 .000 l. 000 l. 000 1.000 l. 000 1 .000 1.000 l. 000 l. 000 1.000 1. 000 l. 000 1. 000 1.000 1.000 1.000 1.000 1 .000 1

. 000 1.000 1.000 1.000 1.000 1.000 1.000 1 .000 1.000 1.000 1.000 l. 000 l. 000 1.000 1. 000 1. 000 1. 000 1.000 1. 000 1.000 1.000 1

. 000 1.000 l. 000 1.000 1 .00 0 1.000 commentPyroxasulfone Dietary Exposure and Risk Assessment PC Code: 090099


### Chronic Analysis DPNumber: 0417422

Filename: C:\Documents and Settings \ tmorton\ My nocuments \ MyFiles \DEEM Files \090099 Pyroxasulfone\Amended Corn 3F8196\090099CHRONICFOODANDWATER.R08 Chemical: Pyroxasulfone RfD(Chron ic) : .02 mg/ kg bw/ day NOEL(Chronic): 0 mg/kg bw/ day RfD(Acute): 1 mg/kg bw/ day NOEL(Acute): 0 mg/ kg bw/ day Date created/last modified: 11-13-2013/12:23:19 Program ver. 3.16, 03

- 08

- d Crop EPA Code Grp Commodity Name Def Res (ppm)
0600347000 6 0600349000 6 0600349001 6 0600350000 6 0600350001 6 0601349500 6AB 0603348000 6C 0603348001 6C 1500120000 15 1500120001 15 1500121000 15 1500121001 15 1500122000 1 5 1 500 123000 15 1500123001 15 1500124000 15 1500124001 15 1500125000 15 1500125001 15 1500126000 15 1500127000 15 1500127001 15 1500381000 15 1500381001 15 1500401000 15 1500401001 15 1500402000 15 1500402001 15 1500403000 15 1500404000 15 2003128000 20C 2003128001 20C 3600222000 36 3600222001 36 3600223000 36 3600223001 36 3600224000 36 3600224001 36 3600225001 36 8601000000 86A 8602000000 86B Soybean, seed Soybean, soy milk Soybean, soy mi l k-babyfood or in Soybean, oil Soybean, oil

- babyfood Soybean, vegetable Soybean, flour Soybean, flour-babyfood Corn, fie l d, flour Corn, field, flour-babyfood Corn, field, meal Corn, field, meal-babyfood Corn, field, bran Corn, field, starch Corn, field, starch

- babyfood Corn, field, syrup Corn, field, syrup
- babyfood Corn, field, oil Corn, field, oil-babyfood Corn, pop Corn, sweet Corn, sweet-babyfood Triticale, flour Triticale, flour

- babyfood Wheat, grain Wheat, grain

- babyfood Wheat, flour Wheat, flour-babyfood Wheat, germ Wheat, bran Cottonseed, oil Cottonseed, oil-babyfood Milk, fat Milk, fat-baby food/infant formu Mi l k, nonfat solids M

il k, nonfat solids-baby food/in M

ilk, water M

ilk, water-babyfood/infant form M

ilk , sugar (lactose)-baby food/ Water, direct, all sources water, indirect, all sources 0.065000 0.065000 0.065000 0.065000 0.065000 0.065000 0.065000 0.065000 0.030000 0

. 03000 0 0.03000 0 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.030000 0.070000 0.070000 0.00 5000 0.00 5000 0.005000 0.0050 00 0.005000 0.005000 0.005000 0.174000 0.174000

Page 9 of 12 Adj.Factors #1 #2
1.000 1.000 1.000 1

. 000 1.000 1.000 1.000 1.00 0 1 .000 1. 000 1.000 1. 000 1.000 1.000 1.000 1.500 1.500 1.000 1.000 1.000 1 .000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1.000 1. 000 1.0 00 1.000 1.000 1.000 1.000 1.000 1.000 1. 000 1.000 1.000 1. 000 1. 000 1. 000 1.000 1.000 1. 000 1.000 1. 000 1.000 1.000 1.000 1.00 0 1.000 1. 000 1.000 1.000 1.000 1.000 1.000 1.000 1. 000 1. 000 1.000 1.000 1. 000 1.000 1.000 1.000 1.000 1.000 1.000 1. 000 1.000 1. 000 1.0 00 1. 000 1. 000 1. 000 1.000 1. 000 Comment

### Pyroxasulfone Dietary Exposure and Risk Assessment PC Co de: 0900 99



### A ttachment 2 :Acute Results DP Num ber: 04 17422

U

. S. EPA DEEM-FCI D ACUTE Anal ysis for PYROXASULFONE Residue file: 090099ACUTEFOODANDWATER.R08 Analysis Date: 11-13

- 2013 / 12:25:41 Residue Ver. 3.16, 03-08-d NHANES 2003

- 2008 2

- Day Adjustment factor #2 NOT used. file dated: 11-13- 2013/12: 22:57 RAC/ FF intake summed over 24 hours Run Comment: ""

Summary calculations--pe r capita :
95th Percentile 99th Percentile 99.9th Percentile Exposure t aRfD Exposure t aRfD Exposure % aRfD



## -- -- ------ 

# -- ----- -
-- --- ---- - - --- -- -- 

## - --- ---- - - 

# --- --- -- Tota l 

### us Popu l ation: 0

. 011740 1.17 0.01930 1 1. 93 0.036509 3

. 65 All Infant s: 0.036394 3.64 0.048855 4.89 0. 071962 7.20 Children 1

- 2: 0.018442 1. 84 0.027605 2.76 0.065857 6.59 Children 3-5: 0.015013 1. so 0.022803 2.28 0.035980 3 .60 Children 6-12: 0.011445 1. 14 0.01823 2 1. 82 0.028366 2. 84 Youth 13-19: 0.009849 0.98 0.015965 1.60 0.023981 2.-40 Adults 20-49: 0.011476 1.15 0.016892 1. 69 0.024560 2.46 Adults 50-99: 0.010239 1. 02 0.015445 1.54 0

. 024112 2.41 Female 1 3-4 9: 0.011621 1.16 0.0 1 69 1 6 1.69 0.023872 2.39
FOOD ONLY

U.S. EPA DEEM

- FCID ACUTE Analysis for PYROXASULFONE Residue f ile: 090099ACUTEFOOD ONLY

. R08 Ver. 3.16, 03

- 08-d NHANES 2003

- 2 00 8 2

- Day Adjustment factor # 2 used. dated: 02-18-2014/14:13 : 26 Ana l ysis Date: 02-18-2014/14:15:48 Residue file RAC/FF intake summed over 24 hours Run Comment: ""

Summary c a lculations

-- per capita:
95 t h Percent i l e 99th Percentile 99.9th Percentile Exposure t aRfD Exposure t aRfD Exposure % aRfD



### -- - -- - --- - -- - - -- -- 

### - --- -- ---- - - -- - - -- 

## - - - ---- --- -- -- --- - Tota l 

### us Popula tion: 0

. 000584 0

. 06 0.000 916 0.09 0.001649 O.H All Inf ant s: 0 .000 893 0 .0 9 0.001284 0.13 0.003000 0.30 Chil dren 1

- 2: 0.001146 0.11 0.001901 0.1 9 0.005656 0.57 Children 3

- 5: 0.001003 0.10 0.001433 0.14 0.003222 0.32 Children 6

- 12: 0

. 000731 0

. 07 0.000995 0. 1 0 0.002088 0.21 Youth 13

- 19: 0. 000471 0

. 05 0.000660 0.07 0. 001126 0.11 Adults 20

- 49: 0.000361 0.04 0.000 545 0.05 0.000867 0.09 Adults 50

- 99: 0. 000271 0.03 0.000413 0.04 0.000959 0.10 Female 13-49: 0.00 0 352 0

. 04 0.000528 0.05 0.000812 0.08



### Page 1 0 

### of 12

### Pyroxasulfone Dietary Exposure and Risk Assessment PC Code : 090099

Attachment 3:Chronic Results 

### DP Number: 0417422

U.S. EPA Ver. 3.16, 03-08-d**0~2M-FCIO** Chronic anal ysis for**PY~OXASULFO NE**  " NHANES 2003

- 2008 2-day Residue file name: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\090099 Pyroxasulfone\Amended Corn 3F8196\090099CHRONICFOODANDWATER

. R08 Adjustment factor #2 used

. Analysis Date 01-15-2014/12 :45:48 Residue file dated: 01

- 15 -2014/12 :44 :39 Reference dose (RfD, Chronic) = .02 mg/kg bw/day
Total exposure by population subgroup

Total Exposure Population

Subgroup
Total 

### us Population Hispanic Non-Hisp

- White Non

- Hisp

- Black Non-Hisp-Other Nu rsing Infants Non-Nurs ing Infants Female 1 3+ PREG Children 1

- 6 Children 7-12 Ma l e 13-19 Female 13-19/NP Male 20+ Female 20+/NP Seniors 55+ All Infants Female 13-50 Children 1

- 2 Children 3

- 5 Children 6-12 Youth 13

- 1 9 Adults 20 -4 9 Adu lts 50-99 Fema l e 13

- 49 mg/kg body wt/day
0.003822 0.003680 0.003922 0.003 17 9 0.004384 0.003404 0.012482 0.0035 85 0.005167 0

. 003334 0. 002710 0.002974 0.003528 0.003943 0.003627 0.009679 0.003760 0.005829 0.00 4898 0.003509 0.002843 0.003 77 4 0.003700 0.003757



### Page ll of 12 Pe rcent of Rfd
19.1% 18 .4% 19

. 6% 15

. 9% 21.9% 17 .0% 62.4% 17.9% 25.8% 16

. 7% 13.5% 14.9% 17 .6% 1 9.7% 1 8

. 1% 48.4% 18.8% 29

. 1% 24 .5% 17.5% 14.2% 1 8.9% 18.5% 18.8%

### Pyroxasulfone Dietary Exposure and Risk As sessment PC Code: 090099

FOOD ONLY 

### DPNumber: 0417422

U.S. EPA Ver. 3.16, 03 -0 8-d DEEM-FCID Chronic analysis for PYROXASULFONE NHANES 2003-2 008 2-day Residue file name: C:\Documents and Settings\tmorton\My Documents\ MyPiles \ DEEM Piles\09 009 9 Pyroxasulfone\Amended Corn 3F819 6\090 099CHRONI CFOOD ONLY.R08 Adj ustment factor #2 use d. Analysis Da te 02- 1 8-20 14 /14:14:37 Residue fi l e dated: 02 -1 8-2014/14:13:54 Reference dose (RfD, Chronic) = .02 mg/kg bw/day
Total exposure by population subgroup

Tota l Exposure Population

Subgroup
Total 

### us Population Hispanic N

on-Hisp-Whit e N

on-H isp-B lack Non -Hi sp-Other Nursing Infants Non

- Nursing Infant s Female 13+ PREG Children 1

- 6 Ch il dren 7 -1 2 Male 13 -1 9 Female 13

- 19 /NP Male 20+ Female 20+/NP Seniors 55+ All Infants Female 13-50 Children 1 -2 Children 3-5 Chi l dren 6

- 12 Youth 13 -1 9 Adults 20

- 49 Adults 50-99 Female 13-49 mg/kg body wt/day
0.000179 0.000202 0.0001 75 0.000173 0.000185 0 .0001 08 0

. 000364 0 .0001 54 0.000500 0.000296 0.000205 0 .0001 68 0.000 134 0.000117 0.000104 0.000285 0.000135 0 .000 5 74 0.000 4 70 0.000316 0

. 000186 0

. 000139 0.0 0010 7 0. 000 135



### Page 12 of 12 Percent of Rfd
0 .9% 1. 0% 0.9% 0.9% 0.9% 0.5 % 1. 8% 0.8% 2.5% 1.5% 1. 0 % 0.8% 0. 7% 0.6% 0 .5% 1. 4% 0.7% 2.9% 2.4% 1. 6% 0.9% 0

. 7% 0.5% 0.7%