VANGUARD HEALTH SYSTEMS, INC.



SUPPLEMENTAL INDENTURE


                        SIXTH SUPPLEMENTAL INDENTURE (this “Supplemental Senior Subordinated Indenture”), dated as of 
October 2, 2007, among Baptist Medical Management Service Organization, LLC, a Delaware limited liability company (“BMM”), MacNeal Physicians Group, LLC, a Delaware limited liability company (“MPG”; BMM and MPG, collectively,
referred to herein as the “New Guarantors”), each of the New Guarantors being a subsidiary of Vanguard Health Holding Company II, LLC, a Delaware limited liability company (“VHS Holdco II”), Vanguard Holding Company II, Inc., a
Delaware corporation and a wholly owned subsidiary of VHS Holdco II (together with VHS Holdco II, the “Issuers”), Vanguard Health Holding Company I, LLC, Vanguard Health Systems, Inc. and U.S. Bank National Association, as trustee under the Senior
Subordinated Indenture referred to below (the “Trustee”).


WITNESSETH


                        WHEREAS, the Issuers and the existing Guarantors have heretofore executed and delivered to the Trustee an indenture (as
amended, supplemented or otherwise modified, the “Senior Subordinated Indenture”), dated as of September 23, 2004 providing for the issuance of 9% Senior Subordinated Notes due 2014 (the “Senior Subordinated Notes”);


                        WHEREAS, Section 4.16 of the Senior Subordinated Indenture provides that under certain circumstances the New Guarantors shall
execute and deliver to the Trustee a supplemental indenture pursuant to which the New Guarantors shall unconditionally guarantee all of the Issuers’ Obligations under the Senior Subordinated Notes and the Senior Subordinated Indenture on the terms and
conditions set forth herein (the “Note Guarantee”); and


                        WHEREAS, pursuant to Section 9.01 of the Senior Subordinated Indenture, the Trustee and the Issuers are authorized to execute
and deliver this Supplemental Senior Subordinated Indenture.


                        NOW, THEREFORE, in consideration of the foregoing and for other good and valuable consideration, the receipt of which is
hereby acknowledged, the New Guarantors, the Issuers and the Trustee mutually covenant and agree for the equal and ratable benefit of the Holders of the Senior Subordinated Notes as follows:


                        1.         DEFINED TERMS.  Defined terms used herein without definition shall
have the meanings assigned to them in the Senior Subordinated Indenture.


                        2.         AGREEMENT TO GUARANTEE.  The New Guarantors hereby agree, jointly and
severally with all existing Guarantors (if any), to provide an unconditional Guarantee on the terms and subject to the conditions set forth in Article 12 of the Senior Subordinated Indenture and to be bound by all other applicable provisions


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of the Senior Subordinated Indenture and the Senior Subordinated Notes and to perform all of the obligations and agreements of a Guarantor under the Senior Subordinated Indenture.  The Guarantee of the New Guarantors shall be subordinated to Senior Debt as
provided in the Senior Subordinated Note Indenture


                        3.         NO RECOURSE AGAINST OTHERS.  No past, present or future director,
manager, officer, employee, incorporator, stockholder or member of the Issuers, any parent entity of the Issuers or any Subsidiary, as such, will have any liability for any obligations of the Issuers or the Guarantors under the Senior Subordinated Notes, this Senior
Subordinated Indenture, the Note Guarantees or for any claim based on, in respect of, or by reason of, such obligations or their creation.  Each Holder of Senior Subordinated Notes by accepting a Senior Subordinated Note waives and releases all such
liability.  The waiver and release are part of the consideration for issuance of the Senior Subordinated Notes.  The waiver may not be effective to waive liabilities under the federal securities laws.


                        4.         NOTICES.  All notices or other communications to the New Guarantors
shall be given as provided in Section 14.02 of the Senior Subordinated Indenture.


                        5.         RATIFICATION OF INDENTURE; SUPPLEMENTAL INDENTURES PART OF
INDENTURE.  Except as expressly amended hereby, the Senior Subordinated Indenture is in all respects ratified and confirmed and all the terms, conditions and provisions thereof shall remain in full force and effect.  This Supplemental Senior Subordinated
Indenture shall form a part of the Senior Subordinated Indenture for all purposes, and every holder of Senior Subordinated Notes heretofore or hereafter authenticated and delivered shall be bound hereby.


                        6.         GOVERNING LAW.  THIS INDENTURE, THE NOTES AND THE SENIOR SUBORDINATED
NOTE GUARANTEES SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK.


                        7.         COUNTERPARTS.  The parties may sign any number of copies of this
Supplemental Senior Subordinated Indenture.  Each signed copy shall be an original, but all of them together represent the same agreement.


                        8.         EFFECT OF HEADINGS.  The Section headings herein are for convenience
only and shall not affect the construction hereof.


                        9.         TRUSTEE MAKES NO REPRESENTATION.  The Trustee makes no representation
as to the validity or sufficiency of this Supplemental Indenture.


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                        IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly executed and attested, all as of
the date first above written.


Dated: October 2, 2007



                                                                             
BAPTIST MEDICAL MANAGEMENT

                                                                             
SERVICE ORGANIZATION, LLC



                                                                             
By:/s/ James H. Spalding                           


                                                                             
Name: James H. Spalding

                                                                             
Title: Senior Vice President



                                                                             
MACNEAL PHYSICIANS GROUP, LLC



                                                                             
By: James H. Spalding                               


                                                                             
Name: James H. Spalding

                                                                             
Title: Senior Vice President






                                                                             
VANGUARD HEALTH HOLDING 

                                                                             
COMPANY II, LLC



                                                                             
By: /s/ James H. Spalding                           


                                                                             
Name: James H. Spalding

                                                                             
Title: Senior Vice President









                                                                             
VANGUARD HOLDING COMPANY

                                                                             
II,INC.



                                                                             
By: /s/ James H. Spalding                           


                                                                             
Name: James H. Spalding

                                                                             
Title: Senior Vice President



                                                                             
VANGUARD HEALTH HOLDING

                                                                             
COMPANY I, LLC



                                                                             
By: /s/ James H. Spalding                           


                                                                             
Name: James H. Spalding

                                                                             
Title: Senior Vice President


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VANGUARD HEALTH SYSTEMS, INC.



                                                                             
By: /s/ James H. Spalding                           


                                                                             
Name: James H. Spalding

                                                                             
Title: Senior Vice President



                                                                             
U.S. BANK NATIONAL ASSOCIATION

                                                                             
as Trustee



                                                                             
By: /s/ Richard Prokosch                           


                                                                             
Name: Richard Prokosch

                                                                             
Title: Vice President


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