Form of Amendment No. 1 to Warrant Certificate



 Exhibit 4.2 
 THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE U.S. SECURITIES ACT, AS AMENDED, OR ANY OTHER APPLICABLE SECURITIES LAWS AND HAVE BEEN ISSUED IN RELIANCE UPON AN EXEMPTION FROM THE REGISTRATION REQUIREMENTS
OF THE SECURITIES ACT AND SUCH OTHER SECURITIES LAWS. NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN MAY BE SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED, OR OTHERWISE DISPOSED OF, EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION
STATEMENT UNDER THE SECURITIES ACT OR AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED PURSUANT TO A VALID EXEMPTION THEREFROM UNDER THE SECURITIES ACT. 
 Warrant No. 0701-  
 AMENDMENT NO. 1 TO 

 WARRANT TO PURCHASE SHARES OF COMMON STOCK OF 
 ORAGENICS, INC. 
 THIS CERTIFIES that, the original warrant dated August 7, 2007 issued to
                    , is hereby amended by Oragenics, Inc. a Florida Corporation (the “Corporation”) as follows: 
 Paragraph 1 is amended to change the exercise price from $0.58 to $0.44. The form of Notice of Exercise is further amended and restated to reflect this
amendment. This amended warrant price is only applicable from January 28, 2008 through February 29, 2008, 5:00 PM, EST. After this time, the warrant price will revert to the original issue price of $0.58. 
 All other terms and conditions shall remain the same. 
 IN WITNESS WHEREOF, the Corporation has caused this Amendment No. 1 to the Warrant to be
executed by its duly authorized officers under its seal, this 28th day of January, 2008. 
  

			
	 ORAGENICS, INC.

		
	 By:
	 	 /s/ Ronald P. Evens

	 Name:
	 	Ronald P. Evens
	 Title:
	 	CEO and President








 NOTICE OF EXERCISE 
 TO: ORAGENICS, INC. 
 The undersigned is the Holder of Warrant No. 0701- as amended by amendment
No. 1 (the “Warrant”) issued by Oragenics, Inc., a Florida Corporation (the “Company”). Capitalized terms used herein and not otherwise defined have the respective meanings set forth in the Warrant. 
 The Warrant is currently exercisable to purchase a total of              Warrant
Shares. 
 The undersigned hereby exercises its right to purchase
             Warrant Shares pursuant to the Warrant and delivers herewith the original Warrant certificate in accordance with the terms of the Warrant and tenders herewith payment of
the exercise price in full, together with all applicable transfer taxes, if any. 
 Payment shall take the form of (check applicable box):

  ̈ in lawful money of the United States; or 
  ̈ the cancellation of such number of Warrant Shares as is necessary, in accordance with the formula set forth in
Section 2(c) of the Warrant, to exercise this Warrant with respect to the maximum number of Warrant Shares purchasable pursuant to the cashless exercise procedure set forth in Section 2(c) of the Warrant. 
 The undersigned hereby requests that the Company issue a certificate or certificates representing said Warrant Shares in the name of the undersigned or
in such other name as is specified below: 
 The Warrant Shares shall be delivered to the following: 
  
  
  
  
  
  
 Accredited Investor. The undersigned is an “accredited investor” as defined in Regulation D promulgated under the Securities Act of
1933, as amended. 
  

					
	 Name of Holder:
	  	  
	  	


					
	Signature of Authorized Signatory of Holder:	  	  
	  	


					
	Name of Authorized Signatory:	  	  
	  	


					
	Title of Authorized Signatory:	  	  
	  	


					
	Telephone Number and E-Mail Address of Authorized Signatory:	  	  
	  	


					
	Date:	  	  
	  	

 (Signature must conform in all respect to the name of Holder as specified on the face of the
Warrant.) 







 ASSIGNMENT FORM 
 (TO ASSIGN THE FOREGOING WARRANT, EXECUTE THIS FORM AND SUPPLY REQUIRED INFORMATION. DO NOT USE THIS FORM TO EXERCISE THE WARRANT.) 
 FOR VALUE RECEIVED, the foregoing Warrant and all rights evidenced thereby are hereby sold, assigned and transferred to
                             whose address is
                                        
    , and                                  is hereby
appointed attorney to transfer said rights on the books of Oragenics, Inc., with full power of substitution in the premises. 
 Dated:
                     
  

			
	 Holder’s Signature:
	  	  

		
	 Holder’s Address:
	  	  

		
		  	  


  

					
	 Signature Guaranteed:
	  	  
	  	

 NOTE: The signature to this Assignment Form must correspond with the name as it appears on the face of the
Warrant, without alteration or enlargement or any change whatsoever, and must be guaranteed by a bank or trust company. Officers of corporations and those acting in a fiduciary or other representative capacity should file proper evidence of
authority to assign the foregoing Warrant.