### Structure Activity Team (SAT) Report

PMN Number: P-09-0075

SAT Date: 12/2/2008

Related cases:

Health related cases:

Ecotox related cases:

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 2 3

Persistence Bioaccum Toxicity Comments

2 1 2 PMN

Exposure Based Review:

Health: No

Ecotox: No

Routes of exposure : Health: Dermal, inhalation, and drinking water

Ecotox: All releases to water

Fate: ;

Keywords: Keywords: SENS-DERMAL, LIVER, KIDNEY, ADRENALS, HEART, AQUATOX-A,C

Summary of Assessment:

Fate: Fate Summary: P-09-0075

FATE: Solid with MP = 63.4 EC (M) log Kow = 3.45 (M); S = 12.9 mg/L at 25 EC (M) VP = 1.35E-4 torr at 25 EC (M) BP = 329.5 EC (NOMO5) based on 328.9 EC EC @ 750 mm (M) H = 2.91E-6 (E) log Koc = 4.06 (E) log Fish BCF = 1.96 (E) POTW removal (%) = 30 via sorption; OECD 301F(Mano Re sp-Givaudan): no biodeg/32d; OECD 301F(Mano Resp-RCC): no biodeg/32d; OECD 301D(Closed Btl): 1.69%/28d; OECD 302C(Inherent Biodeg):no biodeg/32d. Time for complete ultimate aerobic biodeg = moSorption to soils/sediments = strong

Volatilization half-life from a standard river = 294 hrs

Volatilization half-life from a standard lake = 139 da Atmospheric Oxidation Half-life = 4.4 hr via OH radical Atmospheric Oxidation Half-life = 6.2 hr via ozone

PBT Potential: P2B1 *CEB FATE: Migration to ground water = slow

Health:

Health Summary: Absorption is nil through the skin as the neat material, poor through the skin when in solution, and poor through the lungs and GI tract based on physical/chemical properties. Based on the submitted data, there is concern for dermal sensitization and effects on the liver, kidneys, adrenals, and heart. Moderate concern.

Test Data: negative in Salmonella and E coli negative for chromosome aberrations in V79 cells positive for dermal sensitization in the mouse local lymph node assay at 10, 25, and 50%

concentration acute dermal study in rats - no deaths or signs of toxicity at 2000 mg/kg, irritation at site of application

not a dermal irritant in rabbits mild eye irritation which cleared by day 7 acute inhalation study in rats, 4.076 mg/L, 4-hr exposure - no de aths or signs of toxicity acute oral study in rats - no deaths or signs of toxicity at 2000 mg/kg 5-day oral study in rats - no deat hs or clinical signs of toxi city at doses of 200, 600 or 1000 mg/kg; increased liver we ights at 600 and 1000 mg/kg 28-day oral study in rats - no NOEL; NOAEL = 50 mg/ kg; differences in organ weights in liver, kidney, adrenals, minimal to marked myocardial vacuolation at 200 and 1000 mg/kg; minimal to slight hepatocellular hypertr ophy at 200 and 1000 mg/kg; minima l tubular basophilia of the kidneys in all dose groups; minimal hypertrophy of the zona fasciculata (adrenals) at 200 and 1000 mg/kg

Ecotox:

Test Test Test End Predicted Measured Comments Organism Type Point

fish 96-h LC50 0.90 >1.3 daphnid 48-h LC50 0.34 >0.82 green algal 96-h EC50 0.27 >1.3 fish _ chronic value 0.005 daphnid _ chronic value 0.016 0.123 algal _ chronic value 0.096 Sewage Sludge 3-h EC50 _ Sewage Sludge _ Chronic Value _Ecotox Values Comments: Predictions are based on SARs for ; SAR chemical class = ; MW 211; log Kow = 4.84 (EPI), 3.45 (M); pH7; e ffective concentrations based on 100% active ingredients and mean measured concentrations; hardness <180.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Results from four submitted ecotoxicity tests: (to view more details, open th e spreadsheet attached below)

Conclusion: Results from the three limit tests ar e considered valid. No effects were detected (mortality, behavior, morphology, or growth) for thr ee acute tests with fish, daphnia, and algae at the limit of water solubilty c oncentration. In the 21-day reproduc tion study with daphnia, LOEC and NOEC concentrations were determined, allo wing calculation of the geometric mean (ChV). The concern concentration (CoC) may be derived by dividing the calculated ChV from this latter test by an assessment (uncer tainty) factor of 10, yielding a CoC of 0.123 mg/L or 123 μ g/L (ppb). The PMN is of modera te concern for ecotoxicity.

Factors Values Comments

Assessment Factor 10

Concentration of Concern 123 (ppb)

SARs

SAR Class

Ecotox Factors Comments:

SAT Chair: Becky Jones