### SAT Report PMN Number: S-14-0011 SAT Date: 5/20/2014 Print Date: 12/2/2014

Related cases : Yes

Concern levels : Type of Concern: Health Eco Comments Level of Concern: 1-2 2

Persistence Bioaccum Toxicity Comments 2 12

Exposure Based Review : Health: N o Ecotox: Yes
Routes of exposure : Health: Inhalation Ecotox: All releases to water Fate: ; Keywords : Keywords: HEART LUNG KIDNEY MUTA ONCO AQUATOX-A; C
Summary of Assessment :

Fate : Fate Summary: S-14-0011 FATE: Gas with MP = -152.2 C (M) log Kow = 2.00 (M)S = 198.2 mg/L at 25 C (M) VP = 4,873 torr at 25 C (M) BP = -29.4 C (M) H = 5.75E-1 (E) log Koc = 2.13 (E) log Fish BCF = 0.99 (E) log Fish BAF = 1.04 (E) POTW removal (%) = 90-99 via stripping Time for complete ultimate aerobic biodeg = wk Sorption to soils/sediments = low Volatilization half-life from a standard river = 1 hrs Volatilization half-life from a standard lake = 4 da Atmospheric Oxidation Half-life = 16 hr via OH radical Atmospheric Oxidation Half-life = 390 hr via ozone PBT Potential: P2B1 *CEB FATE: Migration to ground water = rapid

Health : Health Summary: The PMN substance is a Under ordinary conditions it will not be absorbed through the skin or GI tract, but absorption is good through the lung based on analogs. There is uncertain of or Michael addition to the terminal double bond. The original submission, was the subject of a Standard Review for human health concerns. There is concern for mutagenicity based on submitted test data; and concern for oncogenicity based on . There also are concerns for adverse effects to the lung, heart, blood, and kidney, as well as for endocrine disruption, based on submitted test data. Test Data: Submitted with the PMN:
Minipig repeat dose (28D) inhalation (whole body) toxicity test: dose levels of 5190 p pm an d 10200 p p m , with no observed adverse effects. N OAEL 10200 p p m

Submitted with
Rabbit acute (single dose) inhalation (1hr whole-body) toxicity test: no lethatlity or adverse effects noted (target concentrations 0,0, 45,000, 100,000 p p m (M) and 0,0, 47,000, 102,000 p p m (F) ; Rabbit (F) repeat dose (three week) inhalation (daily 6hr whole-body) p renatal developmental toxicity study:: 2500, 4000, 5500, and 7500 p pm dose groups, with mortality in the mid and high dose groups associated with lung edema/hemorrhage, as well as heart inflammation at all dose levels, and, heart and kidney necrosis in the mid and high dose groups

Submitted with

Positive in with; negative) in without activation; negative) in other strains of with and without activation;Positive in E. coli with activation, (negative without activation; N egative inhalation mouse micronucleus assay; Rat 4-h inhalation LC0 = 405,800 p p m , no narcosis; Dog cardiac sensitization NOEC = 120,000 p p m (highest dose tested); Rat 14-day inhalation NOEC = 50,000 p p m (highest dose tested); Rat 4-week inhalation NOEC = 50,000 p p m (highest dose tested), N o unscheduled DNA synthesis in male rat liver cells, N o increase in micronuclei in male rat bone marrow [results inconclusive]; Rat 14-week inhalation NOEC = 50,000 p p m (highest dose tested); r Rt developmental toxicity NOEL = 50,000 p p m (highest dose tested) [reported by submitter]; Predicted to be noncarcinogenic [by submitter] in female mouse liver and male rat kidney in a gene expression assay, gene expression changes in male rat kidney suggest potential for endocrine-related effects and changes in body mass index,
, and blood pressure

Ecotox :
Test Organism Test Type Test End Point Predicted Measured Comments

fish 96-h LC50 69 daphnid 48-h LC50 40 green algal 96-h EC50 31 fish

_ chronic value 6.8 daphnid

_ chronic value 4.0

algal

_ chronic value 8.4

Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value _

Ecotox Values Comments: Predictions are based on SARs for chemicals; SAR chemical class = ; log Kow = 2.15 (EPI); gas with bp < 0 C (M); S = 2.14 g/L at 20 C (P); p H7; effective concentrations based on 100% active ingredients and mean measured concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments Assessment Factor 10 Concentration of Concern ( p pb) 400

SARs SAR Class Ecotox Category

Ecotox Factors Comments:SAT Chair: J. Kwiat, 564-7653