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Structure Activity Team (SAT) Report 

PMN Number: P-09-0075 

SAT Date: 12/2/2008 

Related cases:

Health related cases: 

Ecotox related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 2 3 

Persistence Bioaccum Toxicity Comments

 2 1 2 PMN 

Exposure Based Review:

Health: No 

Ecotox: No 

Routes of exposure: Health: Dermal, inhalation, and drinking water 

Ecotox: All releases to water 

Fate: ; 

Keywords: 

Keywords: SENS-DERMAL, LIVER, KIDNEY, ADRENALS, HEART, 

AQUATOX-A,C 

Summary of Assessment:

Fate:

Fate Summary: P-09-0075 

FATE: 

Solid with MP = 63.4 EC (M) 

log Kow = 3.45 (M); 

S = 12.9 mg/L at 25 EC (M) 

VP = 1.35E-4 torr at 25 EC (M) 

BP = 329.5 EC (NOMO5) based on 328.9 EC EC @ 750 mm (M) 

H = 2.91E-6 (E) 

log Koc = 4.06 (E) 

log Fish BCF = 1.96 (E) 

POTW removal (%) = 30 via sorption; OECD 301F(Mano Resp-Givaudan): no biodeg/32d; 

OECD 301F(Mano Resp-RCC): no biodeg/32d; OECD 301D(Closed Btl): 1.69%/28d; 

OECD 302C(Inherent Biodeg):no biodeg/32d. 

Time for complete ultimate aerobic biodeg = mo 

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Sorption to soils/sediments = strong 

Volatilization half-life from a standard river = 294 hrs 

Volatilization half-life from a standard lake = 139 da 

Atmospheric Oxidation Half-life = 4.4 hr via OH radical 

Atmospheric Oxidation Half-life = 6.2 hr via ozone 

PBT Potential: P2B1 

*CEB FATE: Migration to ground water = slow 

Health:

Health Summary: Absorption is nil through the skin as the neat material, poor through the skin 

when in solution, and poor through the lungs and GI tract based on physical/chemical properties. 

Based on the submitted data, there is concern for dermal sensitization and effects on the liver, 

kidneys, adrenals, and heart. Moderate concern. 

Test Data: negative in Salmonella and E coli 

negative for chromosome aberrations in V79 cells 

positive for dermal sensitization in the mouse local lymph node assay at 10, 25, and 50% 

concentration 

acute dermal study in rats - no deaths or signs of toxicity at 2000 mg/kg, irritation at site of 

application 

not a dermal irritant in rabbits 

mild eye irritation which cleared by day 7 

acute inhalation study in rats, 4.076 mg/L, 4-hr exposure - no deaths or signs of toxicity 

acute oral study in rats - no deaths or signs of toxicity at 2000 mg/kg 

5-day oral study in rats - no deaths or clinical signs of toxicity at doses of 200, 600 or 1000 

mg/kg; increased liver weights at 600 and 1000 mg/kg 

28-day oral study in rats - no NOEL; NOAEL = 50 mg/kg; differences in organ weights in liver, 

kidney, adrenals, minimal to marked myocardial vacuolation at 200 and 1000 mg/kg; minimal to 

slight hepatocellular hypertrophy at 200 and 1000 mg/kg; minimal tubular basophilia of the 

kidneys in all dose groups; minimal hypertrophy of the zona fasciculata (adrenals) at 200 and 

1000 mg/kg 

Ecotox:

Test Test Test End Predicted Measured Comments 

Organism Type Point 

fish 96-h LC50 0.90 >1.3 

daphnid 48-h LC50 0.34 >0.82 

green algal 96-h EC50 0.27 >1.3 

fish _ chronic value 0.005 

daphnid _ chronic value 0.016 0.123 

algal _ chronic value 0.096 

Sewage Sludge 3-h EC50 _ 

Sewage Sludge _ Chronic Value _ 

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Ecotox Values Comments: Predictions are based on SARs for ; SAR chemical class = ; 

MW 211; log Kow = 4.84 (EPI), 3.45 (M); pH7; effective concentrations based on 100% active 

ingredients and mean measured concentrations; hardness <180.0 mg/L as CaCO3; and TOC <2.0 

mg/L; 

Results from four submitted ecotoxicity tests: 

(to view more details, open the spreadsheet attached below) 

Conclusion: Results from the three limit tests are considered valid. No effects were detected 

(mortality, behavior, morphology, or growth) for three acute tests with fish, daphnia, and algae at 

the limit of water solubilty concentration. In the 21-day reproduction study with daphnia, LOEC 

and NOEC concentrations were determined, allowing calculation of the geometric mean (ChV). 

The concern concentration (CoC) may be derived by dividing the calculated ChV from this latter 

test by an assessment (uncertainty) factor of 10, yielding a CoC of 0.123 mg/L or 123 μg/L 

(ppb). The PMN is of moderate concern for ecotoxicity. 

 Factors Values Comments 

Assessment Factor 10 

Concentration of Concern 123 

 (ppb) 

 SARs 

 SAR Class 

Ecotox Factors Comments: 

SAT Chair: Becky Jones 

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