SAT Report

PMN Number: S-14-0011

SAT Date: 5/20/2014

Print Date: 12/2/2014

Related cases: Yes

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 1-2 2

 Persistence Bioaccum Toxicity Comments

2 12

Exposure Based Review:

Health: No

Ecotox: Yes

Routes of exposure: Health: Inhalation 

Ecotox: All releases to water

Fate: ;

Keywords:

 Keywords: 

HEART

LUNG

KIDNEY

MUTA

ONCO

AQUATOX-A; C

Summary of Assessment:

 Fate:

Fate Summary: S-14-0011

FATE: 

Gas with MP = -152.2 C (M)

log Kow = 2.00 (M) 

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S = 198.2 mg/L at 25 C (M)

VP = 4,873 torr at 25 C (M)

BP = -29.4 C (M)

H = 5.75E-1 (E)

log Koc = 2.13 (E)

log Fish BCF = 0.99 (E)

log Fish BAF = 1.04 (E) 

POTW removal (%) = 90-99 via stripping

Time for complete ultimate aerobic biodeg = wk

Sorption to soils/sediments = low

Volatilization half-life from a standard river = 1 hrs

Volatilization half-life from a standard lake = 4 da

Atmospheric Oxidation Half-life = 16 hr via OH radical

Atmospheric Oxidation Half-life = 390 hr via ozone

PBT Potential: P2B1

*CEB FATE: Migration to ground water = rapid

 Health:

 Health Summary: The PMN substance is a Under ordinary conditions it 

will not be absorbed through the skin or GI tract, but absorption is good through the lung based 

on analogs. There is uncertain of or Michael addition to the terminal double bond. 

The original submission, was the subject of a Standard Review for human health 

concerns. There is concern for mutagenicity based on submitted test data; and concern for 

oncogenicity based on . There also are concerns for adverse effects to the lung, 

heart, blood, and kidney, as well as for endocrine disruption, based on submitted test data.

 Test Data: 

Submitted with the PMN:

Minipig repeat dose (28D) inhalation (whole body) toxicity test: dose levels of 5190 ppm and

10200 ppm, with no observed adverse effects. NOAEL 10200 ppm

Submitted with 

Rabbit acute (single dose) inhalation (1hr whole-body) toxicity test: no lethatlity or adverse 

effects noted (target concentrations 0,0, 45,000, 100,000 ppm (M) and 0,0, 47,000, 102,000 ppm

(F) ;

Rabbit (F) repeat dose (three week) inhalation (daily 6hr whole-body) prenatal developmental 

toxicity study:: 2500, 4000, 5500, and 7500 ppm dose groups, with mortality in the mid and high 

dose groups associated with lung edema/hemorrhage, as well as heart inflammation at all dose 

levels, and, heart and kidney necrosis in the mid and high dose groups

Submitted with 

Positive in with; negative) in without activation; 

negative) in other strains of with and without activation; 

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Positive in E. coli with activation, (negative without activation; 

Negative inhalation mouse micronucleus assay; 

Rat 4-h inhalation LC0 = 405,800 ppm, no narcosis; 

Dog cardiac sensitization NOEC = 120,000 ppm (highest dose tested); 

Rat 14-day inhalation NOEC = 50,000 ppm (highest dose tested); 

Rat 4-week inhalation NOEC = 50,000 ppm (highest dose tested), 

No unscheduled DNA synthesis in male rat liver cells, 

No increase in micronuclei in male rat bone marrow [results inconclusive]; 

Rat 14-week inhalation NOEC = 50,000 ppm (highest dose tested); r

Rt developmental toxicity NOEL = 50,000 ppm (highest dose tested) [reported by submitter]; 

Predicted to be noncarcinogenic [by submitter] in female mouse liver and male rat kidney in a 

gene expression assay, gene expression changes in male rat kidney suggest potential for 

endocrine-related effects and changes in body mass index, , 

and blood pressure

 Ecotox:

Test Organism Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 69

daphnid 48-h LC50 40

green algal 96-h EC50 31

fish _ chronic value 6.8

daphnid _ chronic 

value

4.0

algal _ chronic 

value

8.4

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic 

Value

_

Ecotox Values Comments: Predictions are based on SARs for chemicals; 

SAR chemical class = ; log Kow = 2.15 (EPI); gas with bp < 0 C 

(M); S = 2.14 g/L at 20 C (P); pH7; effective concentrations based on 100% active ingredients 

and mean measured concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

400

SARs

SAR Class

Ecotox Category 

Ecotox Factors Comments: 

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 SAT Chair: J. Kwiat, 564-7653

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