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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY

AND POLLUTION PREVENTION

 

MEMORANDUM

DRAFT Date: 10/14/2014

SUBJECT: Pendimethalin: Acute and Chronic Aggregate Dietary (Food and Drinking 

Water) Exposure and Risk Assessments in support of the Human Health Risk 

Assessment for New uses on Hops, Low Growing Berry Subgroups 13-07G, 

Onion, bulb subgroup 3-07A, Onion, green subgroup 3-07B, and Sunflower 

Subgroup 20B; Crop Group conversions and expansions for Citrus Fruit Group 

10, Pome Fruit Group 11, Stone Fruit Group 12, and Fruiting Vegetable Group 8. 

PC Code: 108501 DP Barcode: 416577

Decision No.: 484426 Registration No.: 241-245

Petition No.: Regulatory Action: Risk Assessment

Risk Assessment Type: Dietary Case No.:

TXR No.: NA CAS No.: 40487-42-1

MRID No.: NA 40 CFR: 40 CFR §180.361

FROM: P. Yvonne Barnes, Chemist

Risk Assessment Branch (RABVI)

Health Effects Division (HED; 7509P)

THROUGH: William D. Cutchin, Chemist

Thomas Bloem, Chemist

Dietary Exposure Science Advisory Council (DESAC)

AND

Donna S. Davis, acting Chief RABVI

Health Effects Division (HED; mailstop 7509P)

TO: Sidney Jackson, Chemical Review Manager (CRM)

Pesticide Re-evaluation Division (7805P)
Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

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Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure, and risk assessments 

were conducted for pendimethalin using the Dietary Exposure Evaluation Model software with 

the Food Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-

2008 food consumption data from the U.S. Department of Agriculture’s (USDA’s) National 

Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA). 

These analyses were conducted in support of human health risk assessment for the proposed 

establishing new crop subgroups based on the tolerance of existing individual commodities; 

existing crop conversions and expansions; section 3 new use on hop, dried cones. This 

memorandum was reviewed by two peer reviewers of the DESAC as per DESAC standard 

operating procedures (SOP) 2012.1. 

Unrefined acute and chronic dietary exposure assessments were conducted using tolerance-level 

residues for agricultural commodities, 100% crop treated, DEEM® default or empirical 

processing factors, and point estimates for potential drinking water residues (NY Grape scenario) 

that produced the highest estimated drinking water concentrations (EDWCs). 

Acute Dietary Exposure Assessment

The acute dietary risk estimate for the highest exposed population subgroup, all infants is 1.7% 

of the acute population adjusted dose (aPAD) and for the general U. S. population is <1.0% of 

the aPAD at the 95th percentile. HED is concerned when estimated dietary risk exceeds 100%. 

There are no acute dietary risk of concern.

Chronic Dietary Exposure Assessment

The chronic dietary risk estimate for the highest exposed population subgroup, children 1-2 years 

old is 1.7% of the chronic population adjusted dose (cPAD) and for the general U. S. population

is <1.0% of the cPAD. HED is concerned when estimated dietary risk exceeds 100%. There are 

no chronic dietary risk of concern.

Cancer Dietary Exposure Assessment

Pendimethalin is categorized as “Group C, possible human carcinogen." Quantification of risk 

using a non-linear approach; i.e., RfD/PAD, will adequately account for all chronic toxicity, 

including carcinogenicity, that could result from exposure to pendimethalin. 

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). 

This is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the point of 

departure (PoD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in 
Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

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more detail are available on the EPA/pesticides web site: “Available Information on Assessing 

Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, Web-link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf or see SOP 99.6 (20-AUG1999).

The most recent dietary risk assessment for pendimethalin was conducted by Y. Barnes

(05/02/2012, DP Number: D401100).

II. Residue Information

Pendimethalin (N-(1-ethylpropyl)-3,4-dimethyl-2,6-dinitrobenzenenamine) is a selective 

herbicide used for controlling annual grass and broadleaf weeds. It is a meristematic inhibitor 

that interferes with the plant’s cellular division of mitosis and is generally applied early in the 

growing season as a pre-emergent and early post-emergent herbicide. The agricultural uses of 

pendimethalin have been proposed for the aqueous capsule suspension formulation of the enduse product Prowl® H2O (38.7 % a.i.; EPA Registration Number: 241-418), a 3.8 lbs. a.i./gallon 

liquid formulation. Prowl ® H2O can be applied via ground and/or aerial application methods.

The residues of concern in plant commodities, for tolerance enforcement and risk assessment 

purposes is pendimethalin and its 3, 5-dinitrobenzyl alcohol metabolite (DP# 329627, W. Drew, 

07/12/2006). The assessment assumed 100% crop treated. 

Currently, tolerances are established for the herbicide pendimethalin under 40 CFR: §180.361 for

newly proposed subgroups based on existing tolerance for individual representative 

commodities: Low Growing Berry Subgroups 13-07G (0.1 ppm), Onion, bulb subgroup 3-07A

(0.1 ppm), Onion, green subgroup 3-07B (0.2 ppm), and Sunflower Subgroup 20B (0.1 ppm);

Crop Group conversions and expansions based on established crop group tolerance for Citrus 

Fruit Group 10 (0.1 ppm), Pome Fruit Group 11 (0.1 ppm), Stone Fruit Group 12 (0.1 ppm), and 

Fruiting Vegetable Group 8 (0.1 ppm). A new tolerance is proposed and recommended for Hop, 

dried cones (0.1 ppm).

Empirical processing factors obtained from processing data were utilized for processed 

commodities, when available and adequate residues; in grape processed commodities are 

assumed to be the same as the raw commodity. DEEMTM 7.81 processing factors were used for 

the processed commodities, with the exception of grapes, wheat, and citrus (DP Number: 

334173, 08/02/2007). 

Tolerance-level residue values for pendimethalin were incorporated for all RACs, current and 

proposed. 

The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish over the time 

period of 2008: 552 samples - maximum residue = 18 ppb, 2009: 543 samples – maximum 

residue = 13 ppb, and 2010: 384 samples – maximum residue = 74 ppb. Over this 3-year period, 

PDP analyzed ~ 1479 samples of catfish for pendimethalin residues. Detects were found in 42

samples of catfish. As a result, these residues in catfish (fin fish) were included in the dietary

risk assessment. The chronic dietary input for catfish was an average (0.035 ppm) of PDP 
Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

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residue data for pendimethalin and the acute dietary input for catfish used the single highest 

(0.074 ppm) value PDP residue data for pendimethalin. Tolerance for crayfish established at 0.05 

ppm, (D332750 and 345270 C. Olinger, 03/31/2008)

III. Percent Crop Treated Information

Percent crop treated information was not incorporated into this assessment. 

IV. Drinking Water Data

The estimated drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) in the following memorandum: “Tier II 

Estimated Surface Drinking Water Concentrations and Estimated Ground Water Concentration 

(EDWCs) for Pendimethalin for Use in Human Health Risk Assessment,” D334061, J. Breithaupt,

05/08/2007, this DWA were to be used as expressed in the referenced email. (Email: Ibrahim 

Abdel-Saheb 06/18/2014) and incorporated directly into the dietary assessment. Water residues 

were incorporated in the DEEM-FCID into the food categories “water, direct, all sources” and 

“water, indirect, all sources.” 

Table 5.3 Pendimethalin EDWCs for the New York Grape Scenario in Surface Water (2007)

Drinking Water 

Source

(Model) 

1 in 10 year annual peak 

concentration 

1 in 10 year annual 

mean concentration 

36 year annual mean 

concentration 

(μg/L) (μg/L) (μg/L)

Surface Water a 

(PRZM-EXAMS) 77.7 6.0 4.8

Ground Water

SCI- GROW b 0.036 (ug/L)

a From the Tier II PRZM-EXAMS – (NY grape scenario)

b From SCI-GROW model

Values used for risk assessment is bolded

These 1 in 10 year annual peak (acute), 1 in 10 year annual mean (non-cancer chronic), and 36-

year annual mean concentrations (cancer chronic) were derived from modeling pendimethalin 

using the New York grape scenario. Since no degradates have been identified in the metabolism 

studies at significant (>10 % of applied) levels, no degradates of pendimethalin were modeled in 

this assessment.

The drinking water models and their descriptions are available at the EPA internet site: 

http://www.epa.gov/oppefed1/models/water/. 
Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

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V. DEEM-FCID Program and Consumption Information

Pendimethalin acute and chronic dietary exposure assessments were conducted using the DEEMFCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA’s 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups. However, for acute 

exposure assessment, consumption data are retained as individual consumption events. Based on 

analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns 

and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (<1 year old), children 

1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99

years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

For an acute exposure assessment, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministic assessments, any significant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment.

VI. Toxicological Information

Pendimethalin has a low acute toxicity via the oral, dermal, or inhalation route. It is not a dermal 

or eye irritant; and is not a dermal sensitizer. The thyroid is a target organ for pendimethalin. 

Thyroid toxicity in chronic and subchronic rat and mouse studies was manifested as alterations in 

thyroid hormones (decreased total T4, and T3, increased percent of free T4 and T3), increased 

thyroid weight, and microscopic thyroid lesions (including increased thyroid follicular cell 

height, follicular cell hyperplasia, as well as follicular cell adenomas).
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Thyroid tumors were observed in both male and female rats in a chronic/carcinogenicity study. 

There were no tumors observed in the carcinogenicity study in mice. The Health Effects Division 

(HED) Cancer Peer Review Committee classified pendimethalin (03/18/1992 and re-affirmed 

11/01/99) as a "Group C", possible human carcinogen based on a statistically significant 

increased trend and pair-wise comparison between the high dose group and controls for thyroid 

follicular cell adenomas in male and female rats. The Committee also recommended a nonquantitative approach (i.e., non-linear, RfD approach) since mode of action studies are available 

that demonstrate that the thyroid tumors are due to a thyroid-pituitary imbalance, and also since 

pendimethalin was shown to be non-mutagenic in mammalian somatic cells and germ cells. The 

chronic risk assessment is considered to be protective of any cancer effects; therefore, a separate 

quantitative cancer aggregate risk assessment is not required.

The points of departure and uncertainty factors/safety factors used for dietary risk assessment are

summarized in Table 2. 

Table 2. Toxicological Doses and Endpoint for Pendimethalin Human Health Risk Assessment

Exposure/Scenario Point of 

Departure

Uncertainty/FQPA 

Safety Factors

RfD, PAD, Level of Concern 

for Risk Assessment

Study and Toxicological 

Effects

Acute Dietary

(Females 13-49)

No appropriate endpoint was identified including developmental toxicity studies in rats and rabbits.

Acute Dietary

(General population 

including infants and 

children)

NOAEL=100 

mg/kg

UFA = 10X

UFH = 10X

FQPA SF = 1X

Total UF = 100X

Acute RfD = 1

mg/kg/day

aPAD = Acute RfD

 FQPA SF

= 1 mg/kg/day

Acute neurotoxicity study 

(MRID 48695601).

The LOAEL=300 mg/kg, based 

on reduced motor activity for 

males and females on Day 0.

Chronic Dietary (all 

populations) 

NOAEL = 10 

mg/kg/day

UFA = 3X 

UFH = 10X 

FQPA SF = 1X

Total UF = 30X

Chronic RfD = 0.3 

mg/kg/day

cPAD = Chronic RfD

 FQPA SF

= 0.3 mg/kg/day

92- Day thyroid function study 

in rats (MRID 42054601); 56-

day thyroid study in rats (MRID 

43135001); 14- day intra thyroid 

metabolism study in rats (MRID 

43135003).

LOAEL = 31 mg/kg/day based 

on hormonal and 

histopathological changes in the 

thyroid. 

Cancer

Cancer (oral, dermal, 

inhalation)

Group C, possible human carcinogen based on a statistically significant increased trend and pair-wise 

comparison between the high dose group and controls for thyroid follicular cell adenomas in male and 

female rats. A non-quantitative approach (i.e., non-linear, RfD approach) was recommended by the 

Cancer Peer Review Committee since mode of action studies are available.

UF = uncertainty factor, FQPA SF = FQPA safety factor, NOAEL = no observed adverse effect level, LOAEL = lowest observed adverse effect level, PAD = 

population adjusted dose (a = acute, c = chronic), RfD = reference dose, MOE = margin of exposure, LOC = level of concern, NA = Not Applicable. UFA= 

extrapolation from animal to human (interspecies), UFH = potential variation in sensitivity among members of the human population (intra-species).

VII. Results/Discussion 

As stated above, for the acute and the chronic (food and water) dietary assessments, HED is 

concerned when dietary risk exceeds 100%. The DEEM-FCID analyses estimate the dietary

exposure and risk of the general U.S. population and selected population subgroups. The chronic 

results are reported for the general U.S. Population, all infants (<1 year old), children 1-2, 
Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

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children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, females 13 – 49 years and 

adults 50-99 years. The acute results are reported for the females 13-49 years old.

Acute Dietary Exposure Assessment

The acute dietary risk estimate for the highest exposed population subgroup, all infants at 

(0.017009 mg/kg/day) is 1.7% of the acute population adjusted dose (aPAD) and for the general 

U. S. population at (0.007311 mg/kg/day) is <1.0% of the aPAD at the 95th percentile. HED is 

concerned when estimated dietary risk exceeds 100%. There are no acute dietary risks of 

concern.

Chronic Dietary Exposure Assessment

The chronic dietary risk estimate for the highest exposed population subgroup, children 1-2 years 

old at (0.005043 mg/kg/day) is 1.7% of the chronic population adjusted dose (cPAD) and for the 

general U. S. population at (0.001592 mg/kg/day) is <1.0% of the cPAD. HED is concerned 

when estimated dietary risk exceeds 100%. There are no chronic dietary risks of concern.

Cancer Dietary Exposure Assessment

Pendimethalin is categorized as “Group C, possible human carcinogen." Quantification of risk 

using a non-linear approach; i.e., RfD/PAD, will adequately account for all chronic toxicity, 

including carcinogenicity, that could result from exposure to pendimethalin. 

A summary of the acute and chronic dietary results are reported in Table 3.

Table 3. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Pendimethalin

Population Subgroup

Acute Dietary1

(95th Percentile) Chronic Dietary1 Cancer

Dietary 

Exposure 

(mg/kg/day)

% 

aPAD*

Dietary 

Exposure

(mg/kg/day)

% cPAD*

Dietary 

Exposure

(mg/kg/day)

Risk

General U.S. Population 0.007311 < 1 0.001592 < 1

Not 

applicable

Not 

applicable

All Infants (< 1 year old) 0.017009 1.7 0.003195 1.1

Children 1-2 years old 0.015053 1.5 0.005043 1.7

Children 3-5 years old 0.011605 1.2 0.003987 1.3

Children 6-12 years old 0.007796 < 1 0.002329 < 1

Youth 13-19 years old 0.005430 < 1 0.001332 < 1

Adults 20-49 years old 0.005967 < 1 0.001256 < 1

Adults 50+ years old 0.005528 < 1 0.001191 < 1

Females 13-49 years old 0.006124 < 1 0.001248 < 1

*The subpopulation(s) with the highest risk estimates are bolded.
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VIII. Characterization of Inputs/Outputs

These acute and chronic dietary exposure and risk analyses represent a screening level

conservative assessment using tolerance level residues, DEEMTM 7.81 processing factors or 

empirical processing factors were used when available. Further refinements are not needed at 

this time since the reported dietary risk results are not of concern.

IX. Conclusions

As stated above, for acute and chronic (food and water) dietary assessments, HED is concerned 

when estimated dietary risk exceeds 100% of the PAD. These analyses demonstrate that the 

registered uses for pendimethalin will not result in dietary risks of concern. HED is confident 

that the acute and the chronic assessments do not underestimate exposures and risks.

X. List of Attachments

Acute Residue (Food and Water) Input file

Acute Results (Food and Water) file

Chronic Residue Input file 

Chronic Results File
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Attachment 1. Acute Residue Input (Food and Water) File

US EPA Ver. 3.18, 03-08-d

DEEM-FCID Acute analysis for PENDIMETHALIN 

Residue file name: C:\Users\pbarnes\Documents\DEEMRESULTS\Pendimethalin on Hops and Alfalfa 

dietary files\PENDIMETHALIN acute hops and alfalfa 7 22 2014.R08

Analysis Date 07-22-2014 Residue file dated: 07-22-2014/11:45:26

Reference dose: aRfD = 1 mg/kg bw/day NOEL = 100 mg/kg bw/day

Comment: PENDIMETHALIN Hops and Alfalfa

----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Food Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

1800002000 18 Alfalfa, seed 0.100000 1.000 1.000

1400003000 14 Almond 0.100000 1.000 1.000

1400003001 14 Almond-babyfood 0.100000 1.000 1.000

1400004000 14 Almond, oil 0.100000 1.000 1.000

1400004001 14 Almond, oil-babyfood 0.100000 1.000 1.000

1100007000 11 Apple, fruit with peel 0.100000 1.000 1.000

1100008000 11 Apple, peeled fruit 0.100000 1.000 1.000

1100008001 11 Apple, peeled fruit-babyfood 0.100000 1.000 1.000

1100009000 11 Apple, dried 0.100000 8.000 1.000

1100009001 11 Apple, dried-babyfood 0.100000 8.000 1.000

1100010000 11 Apple, juice 0.100000 1.300 1.000

1100010001 11 Apple, juice-babyfood 0.100000 1.300 1.000

1100011000 11 Apple, sauce 0.100000 1.000 1.000

1100011001 11 Apple, sauce-babyfood 0.100000 1.000 1.000

1202012000 12B Apricot 0.100000 1.000 1.000

1202012001 12B Apricot-babyfood 0.100000 1.000 1.000

1202013000 12B Apricot, dried 0.100000 6.000 1.000

1202014000 12B Apricot, juice 0.100000 1.000 1.000

1202014001 12B Apricot, juice-babyfood 0.100000 1.000 1.000

9500016000 O Artichoke, globe 0.100000 1.000 1.000PP#6E7

 Full comment: PP#6E7129

9500019000 O Asparagus 0.150000 1.000 1.000PP#6E7

 Full comment: PP#6E7129

0603030000 6C Bean, black, seed 0.100000 1.000 1.000

0602031000 6B Bean, broad, succulent 0.100000 1.000 1.000

0603032000 6C Bean, broad, seed 0.100000 1.000 1.000

0602033000 6B Bean, cowpea, succulent 0.100000 1.000 1.000

0603034000 6C Bean, cowpea, seed 0.100000 1.000 1.000

0603035000 6C Bean, great northern, seed 0.100000 1.000 1.000

0603036000 6C Bean, kidney, seed 0.100000 1.000 1.000

0602037000 6B Bean, lima, succulent 0.100000 1.000 1.000

0603038000 6C Bean, lima, seed 0.100000 1.000 1.000

0603039000 6C Bean, mung, seed 0.100000 1.000 1.000

0603040000 6C Bean, navy, seed 0.100000 1.000 1.000

0603041000 6C Bean, pink, seed 0.100000 1.000 1.000

0603042000 6C Bean, pinto, seed 0.100000 1.000 1.000

0601043000 6A Bean, snap, succulent 0.100000 1.000 1.000

0601043001 6A Bean, snap, succulent-babyfood 0.100000 1.000 1.000

1302057000 13B Blueberry 0.100000 1.000 1.000

1302057001 13B Blueberry-babyfood 0.100000 1.000 1.000

1400059000 14 Brazil nut 0.100000 1.000 1.000

0501061000 5A Broccoli 0.100000 1.000 1.000PP#6E7

 Full comment: PP#6E7129

0501061001 5A Broccoli-babyfood 0.100000 1.000 1.000PP#6E7

 Full comment: PP#6E7129

0501062000 5A Broccoli, Chinese 0.100000 1.000 1.000PP#6E7

 Full comment: PP#6E7129

0502063000 5B Broccoli raab 0.200000 1.000 1.000

0501064000 5A Brussels sprouts 0.100000 1.000 1.000PP#6E7

 Full comment: PP#6E7129

1400068000 14 Butternut 0.100000 1.000 1.000

0501069000 5A Cabbage 0.100000 1.000 1.000PP#6E7

 Full comment: PP#6E7129

0502070000 5B Cabbage, Chinese, bok choy 0.200000 1.000 1.000

0501071000 5A Cabbage, Chinese, napa 0.100000 1.000 1.000PP#6E7

 Full comment: PP#6E7129

0501072000 5A Cabbage, Chinese, mustard 0.100000 1.000 1.000PP#6E7
Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

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 Full comment: PP#6E7129

0901075000 9A Cantaloupe 0.100000 1.000 1.000

0101078000 1AB Carrot 0.500000 1.000 1.000

0101078001 1AB Carrot-babyfood 0.500000 1.000 1.000

0101079000 1AB Carrot, juice 0.500000 1.000 1.000

1400081000 14 Cashew 0.100000 1.000 1.000

0501083000 5A Cauliflower 0.100000 1.000 1.000PP#6E7

 Full comment: PP#6E7129

1201090000 12A Cherry 0.100000 1.000 1.000

1201090001 12A Cherry-babyfood 0.100000 1.000 1.000

1201091000 12A Cherry, juice 0.100000 1.500 1.000

1201091001 12A Cherry, juice-babyfood 0.100000 1.500 1.000

1400092000 14 Chestnut 0.100000 1.000 1.000

0603098000 6C Chickpea, seed 0.100000 1.000 1.000

0603098001 6C Chickpea, seed-babyfood 0.100000 1.000 1.000

0603099000 6C Chickpea, flour 0.100000 1.000 1.000

0302103000 3B Chive, fresh leaves 0.100000 1.000 1.000

1001106000 10A Citron 0.100000 1.000 1.000

1001107000 10A Citrus hybrids 0.100000 1.000 1.000

1001108000 10A Citrus, oil 0.500000 1.000 1.000

0502117000 5B Collards 0.200000 1.000 1.000

1500120000 15 Corn, field, flour 0.100000 1.000 1.000

1500120001 15 Corn, field, flour-babyfood 0.100000 1.000 1.000

1500121000 15 Corn, field, meal 0.100000 1.000 1.000

1500121001 15 Corn, field, meal-babyfood 0.100000 1.000 1.000

1500122000 15 Corn, field, bran 0.100000 1.000 1.000

1500123000 15 Corn, field, starch 0.100000 1.000 1.000

1500123001 15 Corn, field, starch-babyfood 0.100000 1.000 1.000

1500124000 15 Corn, field, syrup 0.100000 1.500 1.000

1500124001 15 Corn, field, syrup-babyfood 0.100000 1.500 1.000

1500125000 15 Corn, field, oil 0.100000 1.000 1.000

1500125001 15 Corn, field, oil-babyfood 0.100000 1.000 1.000

1500127000 15 Corn, sweet 0.100000 1.000 1.000

1500127001 15 Corn, sweet-babyfood 0.100000 1.000 1.000

2003128000 20C Cottonseed, oil 0.100000 1.000 1.000

2003128001 20C Cottonseed, oil-babyfood 0.100000 1.000 1.000

1100129000 11 Crabapple 0.100000 1.000 1.000

1307130000 13G Cranberry 0.100000 1.000 1.000

1307130001 13G Cranberry-babyfood 0.100000 1.000 1.000

1307131000 13G Cranberry, dried 0.100000 1.000 1.000

1307132000 13G Cranberry, juice 0.100000 1.000 1.000

1307132001 13G Cranberry, juice-babyfood 0.100000 1.000 1.000

0802148000 8BC Eggplant 0.100000 1.000 1.000

1400155000 14 Hazelnut 0.100000 1.000 1.000

1400156000 14 Hazelnut, oil 0.100000 1.000 1.000

8000157000 80 Fish-freshwater finfish 0.074000 1.000 1.000

8000158000 80 Fish-freshwater finfish, farm ra 0.074000 1.000 1.000

8000159000 80 Fish-saltwater finfish, tuna 0.074000 1.000 1.000

8000160000 80 Fish-saltwater finfish, other 0.074000 1.000 1.000

8000161000 80 Fish-shellfish, crustacean 0.050000 1.000 1.000

0301165000 3A Garlic, bulb 0.100000 1.000 1.000

0301165001 3A Garlic, bulb-babyfood 0.100000 1.000 1.000

1302174000 13B Gooseberry 0.100000 1.000 1.000

1304175000 13D Grape 0.100000 1.000 1.000PP#6E7

 Full comment: PP#6E7129

1304176000 13D Grape, juice 0.100000 1.000 1.000change

 Full comment: changed to 0.1 as per D343402

1304176001 13D Grape, juice-babyfood 0.100000 1.000 1.000PP#6E7

 Full comment: PP#6E7129

9500177000 O Grape, leaves 0.100000 1.000 1.000PP#6E7

 Full comment: PP#6E7129

9500178000 O Grape, raisin 0.100000 1.000 1.000PP#6E7

 Full comment: PP#6E7129

1304179000 13D Grape, wine and sherry 0.100000 1.000 1.000PP#6E7

 Full comment: PP#6E7129

1003180000 10C Grapefruit 0.100000 1.000 1.000

1003181000 10C Grapefruit, juice 0.100000 1.000 1.000

0603182000 6C Guar, seed 0.100000 1.000 1.000

0603182001 6C Guar, seed-babyfood 0.100000 1.000 1.000

1400185000 14 Hickory nut 0.100000 1.000 1.000

0901187000 9A Honeydew melon 0.100000 1.000 1.000
Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

Page 11 of 19

9500188000 O Hop 0.100000 1.000 1.000

0502194000 5B Kale 0.200000 1.000 1.000

1304195000 13D Kiwifruit, fuzzy 0.100000 1.000 1.000

0501196000 5A Kohlrabi 0.100000 1.000 1.000PP#6E7

 Full comment: PP#6E7129

1002197000 10B Kumquat 0.100000 1.000 1.000

0302198000 3B Leek 0.200000 1.000 1.000

1002199000 10B Lemon 0.100000 1.000 1.000

1002200000 10B Lemon, juice 0.100000 1.000 1.000

1002200001 10B Lemon, juice-babyfood 0.100000 1.000 1.000

1002201000 10B Lemon, peel 0.100000 1.000 1.000

0603203000 6C Lentil, seed 0.100000 1.000 1.000

0401205000 4A Lettuce, leaf 4.000000 1.000 1.000

1002206000 10B Lime 0.100000 1.000 1.000

1002207000 10B Lime, juice 0.100000 1.000 1.000

1002207001 10B Lime, juice-babyfood 0.100000 1.000 1.000

1100210000 11 Loquat 0.100000 1.000 1.000

1400213000 14 Macadamia nut 0.100000 1.000 1.000

0502229000 5B Mustard greens 0.200000 1.000 1.000

1202230000 12B Nectarine 0.100000 1.000 1.000

0802234000 8BC Okra 0.100000 1.000 1.000

9500235000 O Olive 0.100000 1.000 1.000

9500236000 O Olive, oil 0.100000 1.000 1.000

0301237000 3A Onion, bulb 0.100000 1.000 1.000

0301237001 3A Onion, bulb-babyfood 0.100000 1.000 1.000

0301238000 3A Onion, bulb, dried 0.100000 9.000 1.000

0301238001 3A Onion, bulb, dried-babyfood 0.100000 9.000 1.000

0302239000 3B Onion, green 0.200000 1.000 1.000

1001240000 10A Orange 0.100000 1.000 1.000

1001241000 10A Orange, juice 0.100000 1.000 1.000

1001241001 10A Orange, juice-babyfood 0.100000 1.000 1.000

1001242000 10A Orange, peel 0.100000 1.000 1.000

0602255000 6B Pea, succulent 0.100000 1.000 1.000

0602255001 6B Pea, succulent-babyfood 0.100000 1.000 1.000

0603256000 6C Pea, dry 0.100000 1.000 1.000

0603256001 6C Pea, dry-babyfood 0.100000 1.000 1.000

0601257000 6A Pea, edible podded, succulent 0.100000 1.000 1.000

0603258000 6C Pea, pigeon, seed 0.100000 1.000 1.000

0602259000 6B Pea, pigeon, succulent 0.100000 1.000 1.000

1202260000 12B Peach 0.100000 1.000 1.000

1202260001 12B Peach-babyfood 0.100000 1.000 1.000

1202261000 12B Peach, dried 0.100000 7.000 1.000

1202261001 12B Peach, dried-babyfood 0.100000 7.000 1.000

1202262000 12B Peach, juice 0.100000 1.000 1.000

1202262001 12B Peach, juice-babyfood 0.100000 1.000 1.000

9500263000 O Peanut 0.100000 1.000 1.000

9500264000 O Peanut, butter 0.100000 1.890 1.000

9500265000 O Peanut, oil 0.100000 1.000 1.000

1100266000 11 Pear 0.100000 1.000 1.000

1100266001 11 Pear-babyfood 0.100000 1.000 1.000

1100267000 11 Pear, dried 0.100000 6.250 1.000

1100268000 11 Pear, juice 0.100000 1.000 1.000

1100268001 11 Pear, juice-babyfood 0.100000 1.000 1.000

1400269000 14 Pecan 0.100000 1.000 1.000

0802270000 8B Pepper, bell 0.100000 1.000 1.000

0802270001 8B Pepper, bell-babyfood 0.100000 1.000 1.000

0802271000 8B Pepper, bell, dried 0.100000 1.000 1.000

0802271001 8B Pepper, bell, dried-babyfood 0.100000 1.000 1.000

0802272000 8BC Pepper, nonbell 0.100000 1.000 1.000

0802272001 8BC Pepper, nonbell-babyfood 0.100000 1.000 1.000

0802273000 8BC Pepper, nonbell, dried 0.100000 1.000 1.000

9500275000 O Peppermint 0.200000 1.000 1.000

9500276000 O Peppermint, oil 1.000000 1.000 1.000

1400278000 14 Pine nut 0.100000 1.000 1.000

1400282000 14 Pistachio 0.100000 1.000 1.000

1203285000 12C Plum 0.100000 1.000 1.000

1203285001 12C Plum-babyfood 0.100000 1.000 1.000

1203286000 12C Plum, prune, fresh 0.100000 1.000 1.000

1203286001 12C Plum, prune, fresh-babyfood 0.100000 1.000 1.000

1203287000 12C Plum, prune, dried 0.100000 5.000 1.000

1203287001 12C Plum, prune, dried-babyfood 0.100000 5.000 1.000
Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

Page 12 of 19

1203288000 12C Plum, prune, juice 0.100000 1.400 1.000

1203288001 12C Plum, prune, juice-babyfood 0.100000 1.400 1.000

9500289000 O Pomegranate 0.100000 1.000 1.000

0103296000 1C Potato, chips 0.100000 1.000 1.000

0103297000 1C Potato, dry (granules/ flakes) 0.100000 6.500 1.000

0103297001 1C Potato, dry (granules/ flakes)-b 0.100000 6.500 1.000

0103298000 1C Potato, flour 0.100000 6.500 1.000

0103298001 1C Potato, flour-babyfood 0.100000 6.500 1.000

0103299000 1C Potato, tuber, w/peel 0.100000 1.000 1.000

0103299001 1C Potato, tuber, w/peel-babyfood 0.100000 1.000 1.000

0103300000 1C Potato, tuber, w/o peel 0.100000 1.000 1.000

0103300001 1C Potato, tuber, w/o peel-babyfood 0.100000 1.000 1.000

1003307000 10C Pummelo 0.100000 1.000 1.000

1100310000 11 Quince 0.100000 1.000 1.000

0502318000 5B Rape greens 0.200000 1.000 1.000

1500323000 15 Rice, white 0.100000 1.000 1.000

1500323001 15 Rice, white-babyfood 0.100000 1.000 1.000

1500324000 15 Rice, brown 0.100000 1.000 1.000

1500324001 15 Rice, brown-babyfood 0.100000 1.000 1.000

1500325000 15 Rice, flour 0.100000 1.000 1.000

1500325001 15 Rice, flour-babyfood 0.100000 1.000 1.000

1500326000 15 Rice, bran 0.100000 1.000 1.000

1500326001 15 Rice, bran-babyfood 0.100000 1.000 1.000

2002330000 20B Safflower, oil 0.100000 1.000 1.000

2002330001 20B Safflower, oil-babyfood 0.100000 1.000 1.000

0302338500 3B Shallot, fresh leaves 0.200000 1.000 1.000

1500344000 15 Sorghum, grain 0.100000 1.000 1.000

0600347000 6 Soybean, seed 0.100000 1.000 1.000

0603348000 6C Soybean, flour 0.100000 1.000 1.000

0603348001 6C Soybean, flour-babyfood 0.100000 1.000 1.000

0600349000 6 Soybean, soy milk 0.100000 1.000 1.000

0600349001 6 Soybean, soy milk-babyfood or in 0.100000 1.000 1.000

0600350000 6 Soybean, oil 0.100000 1.000 1.000

0600350001 6 Soybean, oil-babyfood 0.100000 1.000 1.000

9500352000 O Spearmint 0.200000 1.000 1.000

9500353000 O Spearmint, oil 1.000000 1.000 1.000

1307359000 13G Strawberry 0.100000 1.000 1.000

1307359001 13G Strawberry-babyfood 0.100000 1.000 1.000

1307360000 13G Strawberry, juice 0.100000 1.000 1.000

1307360001 13G Strawberry, juice-babyfood 0.100000 1.000 1.000

9500362000 O Sugarcane, sugar 0.100000 1.000 1.000

9500362001 O Sugarcane, sugar-babyfood 0.100000 1.000 1.000

9500363000 O Sugarcane, molasses 0.100000 1.000 1.000

9500363001 O Sugarcane, molasses-babyfood 0.100000 1.000 1.000

2002364000 20B Sunflower, seed 0.100000 1.000 1.000

2002365000 20B Sunflower, oil 0.100000 1.000 1.000

2002365001 20B Sunflower, oil-babyfood 0.100000 1.000 1.000

1001369000 10A Tangerine 0.100000 1.000 1.000

1001370000 10A Tangerine, juice 0.100000 1.000 1.000

0801374000 8A Tomatillo 0.100000 1.000 1.000

0801375000 8A Tomato 0.100000 1.000 1.000

0801375001 8A Tomato-babyfood 0.100000 1.000 1.000

0801376000 8A Tomato, paste 0.100000 5.400 1.000

0801376001 8A Tomato, paste-babyfood 0.100000 5.400 1.000

0801377000 8A Tomato, puree 0.100000 3.300 1.000

0801377001 8A Tomato, puree-babyfood 0.100000 3.300 1.000

0801378000 8A Tomato, dried 0.100000 14.300 1.000

0801378001 8A Tomato, dried-babyfood 0.100000 14.300 1.000

0801379000 8A Tomato, juice 0.100000 1.500 1.000

0801380000 8A Tomato, Tree 0.100000 1.000 1.000

0502389000 5B Turnip, greens 0.200000 1.000 1.000

1400391000 14 Walnut 0.100000 1.000 1.000

8601000000 86A Water, direct, all sources 0.077700 1.000 1.000

8602000000 86B Water, indirect, all sources 0.077700 1.000 1.000

0901399000 9A Watermelon 0.100000 1.000 1.000

0901400000 9A Watermelon, juice 0.100000 1.000 1.000

1500401000 15 Wheat, grain 0.100000 1.000 1.000

1500401001 15 Wheat, grain-babyfood 0.100000 1.000 1.000

1500402000 15 Wheat, flour 0.100000 1.400 1.000

1500402001 15 Wheat, flour-babyfood 0.100000 1.400 1.000

1500403000 15 Wheat, germ 0.100000 8.000 1.000
Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

Page 13 of 19

1500404000 15 Wheat, bran 0.100000 8.000 1.000

1500405000 15 Wild rice 0.100000 1.000 1.000

0301338000 3A Shallot, bulb 0.100000 1.000 1.000

1901102500 19A Chive, dried leaves 0.100000 1.000 1.000

Attachment 2. Acute Results (Food and Water) File

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for PENDIMETHALIN NHANES 2003-2008 2-Day

Residue file: PENDIMETHALIN acute hops and alfalfa 7 22 2014.R08

 Adjustment factor #2 used.

Analysis Date: 07-22-2014/11:47:09 Residue file dated: 07-22-2014/11:45:26

NOEL (Acute) = 100.000000 mg/kg body-wt/day

RAC/FF intake summed over 24 hours

Run Comment: "PENDIMETHALIN Hops and Alfalfa"

===============================================================================

Summary calculations--per capita:

--- 95th Percentile---- --- 99th Percentile---- ---99.9th Percentile----

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Total US Population:

 0.007311 0.73 13678 0.011583 1.16 8633 0.018799 1.88 5319 

All Infants:

 0.017009 1.70 5879 0.023060 2.31 4336 0.027729 2.77 3606 

Female 13-50:

 0.006106 0.61 16376 0.008599 0.86 11629 0.012530 1.25 7981 

Children 1-2:

 0.015053 1.51 6643 0.019900 1.99 5025 0.033249 3.32 3007 

Children 3-5:

 0.011605 1.16 8616 0.016573 1.66 6033 0.020131 2.01 4967 

Children 6-12:

 0.007796 0.78 12826 0.011329 1.13 8826 0.015618 1.56 6402 

Youth 13-19:

 0.005430 0.54 18416 0.008251 0.83 12120 0.010560 1.06 9469 

Adults 20-49:

 0.005967 0.60 16758 0.008613 0.86 11610 0.012261 1.23 8156 

Adults 50-99:

 0.005528 0.55 18089 0.007899 0.79 12660 0.012146 1.21 8233 

Female 13-49:

 0.006124 0.61 16330 0.008575 0.86 11661 0.012516 1.25 7989 
Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

Page 14 of 19

Attachment 3. Chronic Residue Input File

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for PENDIMETHALIN 

Residue file: C:\Users\pbarnes\Documents\DEEMRESULTS\Pendimethalin on Hops and Alfalfa 

dietary files\PENDIMETHALIN chronic hops and alfalfa 7 22 2014.R08

 Adjust. #2 used

Analysis Date 07-22-2014 Residue file dated: 07-22-2014/11:49:32

Reference dose (RfD) = 0.3 mg/kg bw/day

Comment:PENDIMETHALIN Hops and Alfalfa

----------------------------------------------------------------------------------

Food Crop Residue Adj.Factors

EPA Code Grp Food Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------

1800002000 18 Alfalfa, seed 0.100000 1.000 1.000 

1400003000 14 Almond 0.100000 1.000 1.000 

1400003001 14 Almond-babyfood 0.100000 1.000 1.000 

1400004000 14 Almond, oil 0.100000 1.000 1.000 

1400004001 14 Almond, oil-babyfood 0.100000 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.100000 1.000 1.000 

1100008000 11 Apple, peeled fruit 0.100000 1.000 1.000 

1100008001 11 Apple, peeled fruit-babyfood 0.100000 1.000 1.000 

1100009000 11 Apple, dried 0.100000 8.000 1.000 

1100009001 11 Apple, dried-babyfood 0.100000 8.000 1.000 

1100010000 11 Apple, juice 0.100000 1.300 1.000 

1100010001 11 Apple, juice-babyfood 0.100000 1.300 1.000 

1100011000 11 Apple, sauce 0.100000 1.000 1.000 

1100011001 11 Apple, sauce-babyfood 0.100000 1.000 1.000 

1202012000 12B Apricot 0.100000 1.000 1.000 

1202012001 12B Apricot-babyfood 0.100000 1.000 1.000 

1202013000 12B Apricot, dried 0.100000 6.000 1.000 

1202014000 12B Apricot, juice 0.100000 1.000 1.000 

1202014001 12B Apricot, juice-babyfood 0.100000 1.000 1.000 

9500016000 O Artichoke, globe 0.100000 1.000 1.000 

9500019000 O Asparagus 0.150000 1.000 1.000 

0603030000 6C Bean, black, seed 0.100000 1.000 1.000 

0602031000 6B Bean, broad, succulent 0.100000 1.000 1.000 

0603032000 6C Bean, broad, seed 0.100000 1.000 1.000 

0602033000 6B Bean, cowpea, succulent 0.100000 1.000 1.000 

0603034000 6C Bean, cowpea, seed 0.100000 1.000 1.000 

0603035000 6C Bean, great northern, seed 0.100000 1.000 1.000 

0603036000 6C Bean, kidney, seed 0.100000 1.000 1.000 

0602037000 6B Bean, lima, succulent 0.100000 1.000 1.000 

0603038000 6C Bean, lima, seed 0.100000 1.000 1.000 

0603039000 6C Bean, mung, seed 0.100000 1.000 1.000 

0603040000 6C Bean, navy, seed 0.100000 1.000 1.000 

0603041000 6C Bean, pink, seed 0.100000 1.000 1.000 

0603042000 6C Bean, pinto, seed 0.100000 1.000 1.000 

0601043000 6A Bean, snap, succulent 0.100000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.100000 1.000 1.000 

1302057000 13B Blueberry 0.100000 1.000 1.000 

1302057001 13B Blueberry-babyfood 0.100000 1.000 1.000 

1400059000 14 Brazil nut 0.100000 1.000 1.000 

0501061000 5A Broccoli 0.100000 1.000 1.000 

0501061001 5A Broccoli-babyfood 0.100000 1.000 1.000 

0501062000 5A Broccoli, Chinese 0.100000 1.000 1.000 

0502063000 5B Broccoli raab 0.200000 1.000 1.000 

0501064000 5A Brussels sprouts 0.100000 1.000 1.000 

1400068000 14 Butternut 0.100000 1.000 1.000 

0501069000 5A Cabbage 0.100000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 0.200000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 0.100000 1.000 1.000 
Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

Page 15 of 19

0501072000 5A Cabbage, Chinese, mustard 0.100000 1.000 1.000 

0901075000 9A Cantaloupe 0.100000 1.000 1.000 

0101078000 1AB Carrot 0.500000 1.000 1.000 

0101078001 1AB Carrot-babyfood 0.500000 1.000 1.000 

0101079000 1AB Carrot, juice 0.500000 1.000 1.000 

1400081000 14 Cashew 0.100000 1.000 1.000 

0501083000 5A Cauliflower 0.100000 1.000 1.000 

1201090000 12A Cherry 0.100000 1.000 1.000 

1201090001 12A Cherry-babyfood 0.100000 1.000 1.000 

1201091000 12A Cherry, juice 0.100000 1.500 1.000 

1201091001 12A Cherry, juice-babyfood 0.100000 1.500 1.000 

1400092000 14 Chestnut 0.100000 1.000 1.000 

0603098000 6C Chickpea, seed 0.100000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 0.100000 1.000 1.000 

0603099000 6C Chickpea, flour 0.100000 1.000 1.000 

0302103000 3B Chive, fresh leaves 0.100000 1.000 1.000 

1001106000 10A Citron 0.100000 1.000 1.000 

1001107000 10A Citrus hybrids 0.100000 1.000 1.000 

1001108000 10A Citrus, oil 0.500000 1.000 1.000 

0502117000 5B Collards 0.200000 1.000 1.000 

1500120000 15 Corn, field, flour 0.100000 1.000 1.000 

1500120001 15 Corn, field, flour-babyfood 0.100000 1.000 1.000 

1500121000 15 Corn, field, meal 0.100000 1.000 1.000 

1500121001 15 Corn, field, meal-babyfood 0.100000 1.000 1.000 

1500122000 15 Corn, field, bran 0.100000 1.000 1.000 

1500123000 15 Corn, field, starch 0.100000 1.000 1.000 

1500123001 15 Corn, field, starch-babyfood 0.100000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.100000 1.500 1.000 

1500124001 15 Corn, field, syrup-babyfood 0.100000 1.500 1.000 

1500125000 15 Corn, field, oil 0.100000 1.000 1.000 

1500125001 15 Corn, field, oil-babyfood 0.100000 1.000 1.000 

1500127000 15 Corn, sweet 0.100000 1.000 1.000 

1500127001 15 Corn, sweet-babyfood 0.100000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.100000 1.000 1.000 

2003128001 20C Cottonseed, oil-babyfood 0.100000 1.000 1.000 

1100129000 11 Crabapple 0.100000 1.000 1.000 

1307130000 13G Cranberry 0.100000 1.000 1.000 

1307130001 13G Cranberry-babyfood 0.100000 1.000 1.000 

1307131000 13G Cranberry, dried 0.100000 1.000 1.000 

1307132000 13G Cranberry, juice 0.100000 1.000 1.000 

1307132001 13G Cranberry, juice-babyfood 0.100000 1.000 1.000 

0802148000 8BC Eggplant 0.100000 1.000 1.000 

1400155000 14 Hazelnut 0.100000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.100000 1.000 1.000 

8000157000 80 Fish-freshwater finfish 0.035000 1.000 1.000 

8000158000 80 Fish-freshwater finfish, farm ra 0.035000 1.000 1.000 

8000159000 80 Fish-saltwater finfish, tuna 0.035000 1.000 1.000 

8000160000 80 Fish-saltwater finfish, other 0.035000 1.000 1.000 

8000161000 80 Fish-shellfish, crustacean 0.050000 1.000 1.000 

0301165000 3A Garlic, bulb 0.100000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 0.100000 1.000 1.000 

1302174000 13B Gooseberry 0.100000 1.000 1.000 

1304175000 13D Grape 0.100000 1.000 1.000 

1304176000 13D Grape, juice 0.100000 1.000 1.000 

1304176001 13D Grape, juice-babyfood 0.100000 1.000 1.000 

9500177000 O Grape, leaves 0.100000 1.000 1.000 

9500178000 O Grape, raisin 0.100000 1.000 1.000 

1304179000 13D Grape, wine and sherry 0.100000 1.000 1.000 

1003180000 10C Grapefruit 0.100000 1.000 1.000 

1003181000 10C Grapefruit, juice 0.100000 1.000 1.000 

0603182000 6C Guar, seed 0.100000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 0.100000 1.000 1.000 

1400185000 14 Hickory nut 0.100000 1.000 1.000 
Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

Page 16 of 19

0901187000 9A Honeydew melon 0.100000 1.000 1.000 

9500188000 O Hop 0.100000 1.000 1.000 

0502194000 5B Kale 0.200000 1.000 1.000 

1304195000 13D Kiwifruit, fuzzy 0.100000 1.000 1.000 

0501196000 5A Kohlrabi 0.100000 1.000 1.000 

1002197000 10B Kumquat 0.100000 1.000 1.000 

0302198000 3B Leek 0.200000 1.000 1.000 

1002199000 10B Lemon 0.100000 1.000 1.000 

1002200000 10B Lemon, juice 0.100000 1.000 1.000 

1002200001 10B Lemon, juice-babyfood 0.100000 1.000 1.000 

1002201000 10B Lemon, peel 0.100000 1.000 1.000 

0603203000 6C Lentil, seed 0.100000 1.000 1.000 

0401205000 4A Lettuce, leaf 4.000000 1.000 1.000 

1002206000 10B Lime 0.100000 1.000 1.000 

1002207000 10B Lime, juice 0.100000 1.000 1.000 

1002207001 10B Lime, juice-babyfood 0.100000 1.000 1.000 

1100210000 11 Loquat 0.100000 1.000 1.000 

1400213000 14 Macadamia nut 0.100000 1.000 1.000 

0502229000 5B Mustard greens 0.200000 1.000 1.000 

1202230000 12B Nectarine 0.100000 1.000 1.000 

0802234000 8BC Okra 0.100000 1.000 1.000 

9500235000 O Olive 0.100000 1.000 1.000 

9500236000 O Olive, oil 0.100000 1.000 1.000 

0301237000 3A Onion, bulb 0.100000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 0.100000 1.000 1.000 

0301238000 3A Onion, bulb, dried 0.100000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 0.100000 9.000 1.000 

0302239000 3B Onion, green 0.200000 1.000 1.000 

1001240000 10A Orange 0.100000 1.000 1.000 

1001241000 10A Orange, juice 0.100000 1.000 1.000 

1001241001 10A Orange, juice-babyfood 0.100000 1.000 1.000 

1001242000 10A Orange, peel 0.100000 1.000 1.000 

0602255000 6B Pea, succulent 0.100000 1.000 1.000 

0602255001 6B Pea, succulent-babyfood 0.100000 1.000 1.000 

0603256000 6C Pea, dry 0.100000 1.000 1.000 

0603256001 6C Pea, dry-babyfood 0.100000 1.000 1.000 

0601257000 6A Pea, edible podded, succulent 0.100000 1.000 1.000 

0603258000 6C Pea, pigeon, seed 0.100000 1.000 1.000 

0602259000 6B Pea, pigeon, succulent 0.100000 1.000 1.000 

1202260000 12B Peach 0.100000 1.000 1.000 

1202260001 12B Peach-babyfood 0.100000 1.000 1.000 

1202261000 12B Peach, dried 0.100000 7.000 1.000 

1202261001 12B Peach, dried-babyfood 0.100000 7.000 1.000 

1202262000 12B Peach, juice 0.100000 1.000 1.000 

1202262001 12B Peach, juice-babyfood 0.100000 1.000 1.000 

9500263000 O Peanut 0.100000 1.000 1.000 

9500264000 O Peanut, butter 0.100000 1.890 1.000 

9500265000 O Peanut, oil 0.100000 1.000 1.000 

1100266000 11 Pear 0.100000 1.000 1.000 

1100266001 11 Pear-babyfood 0.100000 1.000 1.000 

1100267000 11 Pear, dried 0.100000 6.250 1.000 

1100268000 11 Pear, juice 0.100000 1.000 1.000 

1100268001 11 Pear, juice-babyfood 0.100000 1.000 1.000 

1400269000 14 Pecan 0.100000 1.000 1.000 

0802270000 8B Pepper, bell 0.100000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 0.100000 1.000 1.000 

0802271000 8B Pepper, bell, dried 0.100000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 0.100000 1.000 1.000 

0802272000 8BC Pepper, nonbell 0.100000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 0.100000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 0.100000 1.000 1.000 

9500275000 O Peppermint 0.200000 1.000 1.000 

9500276000 O Peppermint, oil 1.000000 1.000 1.000 
Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

Page 17 of 19

1400278000 14 Pine nut 0.100000 1.000 1.000 

1400282000 14 Pistachio 0.100000 1.000 1.000 

1203285000 12C Plum 0.100000 1.000 1.000 

1203285001 12C Plum-babyfood 0.100000 1.000 1.000 

1203286000 12C Plum, prune, fresh 0.100000 1.000 1.000 

1203286001 12C Plum, prune, fresh-babyfood 0.100000 1.000 1.000 

1203287000 12C Plum, prune, dried 0.100000 5.000 1.000 

1203287001 12C Plum, prune, dried-babyfood 0.100000 5.000 1.000 

1203288000 12C Plum, prune, juice 0.100000 1.400 1.000 

1203288001 12C Plum, prune, juice-babyfood 0.100000 1.400 1.000 

9500289000 O Pomegranate 0.100000 1.000 1.000 

0103296000 1C Potato, chips 0.100000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 0.100000 6.500 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 0.100000 6.500 1.000 

0103298000 1C Potato, flour 0.100000 6.500 1.000 

0103298001 1C Potato, flour-babyfood 0.100000 6.500 1.000 

0103299000 1C Potato, tuber, w/peel 0.100000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.100000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.100000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.100000 1.000 1.000 

1003307000 10C Pummelo 0.100000 1.000 1.000 

1100310000 11 Quince 0.100000 1.000 1.000 

0502318000 5B Rape greens 0.200000 1.000 1.000 

1500323000 15 Rice, white 0.100000 1.000 1.000 

1500323001 15 Rice, white-babyfood 0.100000 1.000 1.000 

1500324000 15 Rice, brown 0.100000 1.000 1.000 

1500324001 15 Rice, brown-babyfood 0.100000 1.000 1.000 

1500325000 15 Rice, flour 0.100000 1.000 1.000 

1500325001 15 Rice, flour-babyfood 0.100000 1.000 1.000 

1500326000 15 Rice, bran 0.100000 1.000 1.000 

1500326001 15 Rice, bran-babyfood 0.100000 1.000 1.000 

2002330000 20B Safflower, oil 0.100000 1.000 1.000 

2002330001 20B Safflower, oil-babyfood 0.100000 1.000 1.000 

0302338500 3B Shallot, fresh leaves 0.200000 1.000 1.000 

1500344000 15 Sorghum, grain 0.100000 1.000 1.000 

0600347000 6 Soybean, seed 0.100000 1.000 1.000 

0603348000 6C Soybean, flour 0.100000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 0.100000 1.000 1.000 

0600349000 6 Soybean, soy milk 0.100000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 0.100000 1.000 1.000 

0600350000 6 Soybean, oil 0.100000 1.000 1.000 

0600350001 6 Soybean, oil-babyfood 0.100000 1.000 1.000 

9500352000 O Spearmint 0.200000 1.000 1.000 

9500353000 O Spearmint, oil 1.000000 1.000 1.000 

1307359000 13G Strawberry 0.100000 1.000 1.000 

1307359001 13G Strawberry-babyfood 0.100000 1.000 1.000 

1307360000 13G Strawberry, juice 0.100000 1.000 1.000 

1307360001 13G Strawberry, juice-babyfood 0.100000 1.000 1.000 

9500362000 O Sugarcane, sugar 0.100000 1.000 1.000 

9500362001 O Sugarcane, sugar-babyfood 0.100000 1.000 1.000 

9500363000 O Sugarcane, molasses 0.100000 1.000 1.000 

9500363001 O Sugarcane, molasses-babyfood 0.100000 1.000 1.000 

2002364000 20B Sunflower, seed 0.100000 1.000 1.000 

2002365000 20B Sunflower, oil 0.100000 1.000 1.000 

2002365001 20B Sunflower, oil-babyfood 0.100000 1.000 1.000 

1001369000 10A Tangerine 0.100000 1.000 1.000 

1001370000 10A Tangerine, juice 0.100000 1.000 1.000 

0801374000 8A Tomatillo 0.100000 1.000 1.000 

0801375000 8A Tomato 0.100000 1.000 1.000 

0801375001 8A Tomato-babyfood 0.100000 1.000 1.000 

0801376000 8A Tomato, paste 0.100000 5.400 1.000 

0801376001 8A Tomato, paste-babyfood 0.100000 5.400 1.000 

0801377000 8A Tomato, puree 0.100000 3.300 1.000 
Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

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0801377001 8A Tomato, puree-babyfood 0.100000 3.300 1.000 

0801378000 8A Tomato, dried 0.100000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 0.100000 14.300 1.000 

0801379000 8A Tomato, juice 0.100000 1.500 1.000 

0801380000 8A Tomato, Tree 0.100000 1.000 1.000 

0502389000 5B Turnip, greens 0.200000 1.000 1.000 

1400391000 14 Walnut 0.100000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.006000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.006000 1.000 1.000 

0901399000 9A Watermelon 0.100000 1.000 1.000 

0901400000 9A Watermelon, juice 0.100000 1.000 1.000 

1500401000 15 Wheat, grain 0.100000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.100000 1.000 1.000 

1500402000 15 Wheat, flour 0.100000 1.400 1.000 

1500402001 15 Wheat, flour-babyfood 0.100000 1.400 1.000 

1500403000 15 Wheat, germ 0.100000 8.000 1.000 

1500404000 15 Wheat, bran 0.100000 8.000 1.000 

1500405000 15 Wild rice 0.100000 1.000 1.000 

0301338000 3A Shallot, bulb 0.100000 1.000 1.000 

1901102500 19A Chive, dried leaves 0.100000 1.000 1.000 

Attachment 4. Chronic Results File

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for PENDIMETHALIN NHANES 2003-2008 2-day

Residue file name: C:\Users\pbarnes\Documents\DEEMRESULTS\Pendimethalin on Hops and Alfalfa 

dietary files\PENDIMETHALIN chronic hops and alfalfa 7 22 2014.R08

 Adjustment factor #2 used.

Analysis Date 07-22-2014/11:50:07 Residue file dated: 07-22-2014/11:49:32

Reference dose (RfD, Chronic) = .3 mg/kg bw/day

COMMENT 1: PENDIMETHALIN Hops and Alfalfa

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.001592 0.5%

Hispanic 0.001767 0.6%

Non-Hisp-White 0.001559 0.5%

Non-Hisp-Black 0.001513 0.5%

Non-Hisp-Other 0.001768 0.6%

Nursing Infants 0.001819 0.6%

Non-Nursing Infants 0.003809 1.3%

Female 13+ PREG 0.001443 0.5%

Children 1-6 0.004253 1.4%

Children 7-12 0.002154 0.7%

Male 13-19 0.001399 0.5%

Female 13-19/NP 0.001266 0.4%

Male 20+ 0.001224 0.4%

Female 20+/NP 0.001225 0.4%

Seniors 55+ 0.001175 0.4%

All Infants 0.003195 1.1%

Female 13-50 0.001250 0.4%

Children 1-2 0.005043 1.7%

Children 3-5 0.003987 1.3%

Children 6-12 0.002329 0.8%

Youth 13-19 0.001332 0.4%

Adults 20-49 0.001256 0.4%

Adults 50-99 0.001191 0.4%

Female 13-49 0.001248 0.4%

-------------------------------------------------------------------------------
Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

Page 19 of 19

References

Drinking Water Assessment for Pendimethalin for Cabbage, Asparagus, Bearing Grapes, and Artichoke;

DP Barcode D334061; J. Breithaupt; 05/08/2007