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                                                                   EXHIBIT 10.45

                         AGREEMENT RELATED TO SEVERANCE

This Agreement (this "Agreement"), dated as of November 22, 2002, is between
Paradigm Genetics, Inc., a Delaware corporation ("Paradigm") and James D. Bucci,
currently employed as Paradigm's Vice President of Human Resources
("Executive"). This document supercedes the Employment Agreement dated May 1,
2002 with changes incorporated at the request of the Paradigm Board of
Directors.

1.    As an inducement for Executive to remain in his current position, Paradigm
      agrees that Executive will be entitled to the severance benefits described
      in Paragraph 3 if Executive's employment with Paradigm is terminated
      without "Cause". For purposes of this Agreement, Cause" for termination
      shall mean: (a) conviction of, or pleading guilty or nolo contendere to, a
      felony or other crime involving theft, fraud or moral turpitude; (b) drug
      or alcohol abuse; (c) Executive's material breach of this Agreement,
      including failure to cure unsatisfactory job performance after written
      notice and a 60 day period to cure; (d) Executive's refusal to abide by or
      comply with the directives of the Board; (e) Executive's dishonesty,
      fraud, or misconduct with respect to the business affairs of the Company,
      including, without limitation, fraud, misappropriation or embezzlement;
      (f) intentional damage of any property worth in excess of $1,000 of the
      Company; or (g) conduct by Executive which demonstrates gross unfitness to
      serve.

2.    In return for the severance benefits described in Paragraph 3, which
      Executive acknowledges exceed the benefits to which Executive otherwise is
      entitled, Executive agrees to execute a release in a form substantially
      similar to the release attached to this Agreement as Attachment A. The
      release will be dated as of Executive's final day of employment.

3.    If Executive is terminated by Paradigm without Cause, Executive shall be
      entitled to the following benefits:

      a)    Paradigm will continue to pay Executive his current salary and
            provide his current healthcare benefits (less applicable deductions
            and withholdings) for up to twelve (12) months following the
            Executive's final date of employment. Executive must use diligent
            documented efforts to obtain employment. Executive will continue to
            receive salary and benefits as set forth above during this twelve
            (12) month period as long as he is unable to secure comparable
            regular, full time employment or a consulting engagement lasting for
            more than six (6) months.

      b)    If the Company is acquired or a change of control of ownership with
            respect to the Company (as defined below) occurs at anytime during
            the twelve (12) month severance period, described above, all amounts
            of salary and the cash equivalent of the cost of COBRA expense for
            the remainder of the twelve (12) month period shall be due and
            payable to Executive in full.

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      c)    If the Company is acquired or a change of control of ownership with
            respect to the Company (as defined below) occurs, Paradigm will
            increase two-fold the amount of stock options otherwise vested up to
            100%. If redundancy occurs within twelve (12) months of a change of
            control, Executive is entitled to a full twelve (12) months of
            severance pay on a non-contingent basis.

            "Change of Control" means the occurrence of any of the following
            events: (a) Ownership. Any "Person" (as such term is used in
            Sections 13(d) and 14(d) of the Securities Exchange Act of 1934, as
            amended) becomes the "Beneficial Owner" (as defined in Rule 13d-3
            under said Act), directly or indirectly, of securities of the
            Company representing 50% or more of the total voting power
            represented by the Company's then outstanding voting securities
            (excluding for this purpose the Company or its Affiliates or any
            employee benefit plan of the Company) pursuant to a transaction or a
            series of related transactions which the Board of Directors does not
            approve; or (b) Merger/Sale of Assets. A merger or consolidation of
            the Company whether or not approved by the Board of Directors, other
            than a merger or consolidation which would result in the voting
            securities of the Company outstanding immediately prior thereto
            continuing to represent (either by remaining outstanding or by being
            converted into voting securities of the surviving entity or the
            parent of such corporation) at least 80% of the total voting power
            represented by the voting securities of the Company or such
            surviving entity or parent of such corporation outstanding
            immediately after such merger or consolidation, or the stockholders
            of the Company approve an agreement for the sale or disposition by
            the Company of all or substantially all of the Company's assets.

4.    Executive agrees that for the longer of twelve (12) months after the
      separation of his employment with the Company, or any period for which he
      is receiving severance under the terms of this Separation Agreement, he
      will not become engaged in any "Competitive Activity" (as defined below).

      "Competitive Activity" means: (A) Directly or indirectly, engaging,
      assisting or participating in, whether as a President, CEO, Vice
      President, director, officer, employee, agent, manager, consultant,
      partner, owner or independent contractor or other participant, any
      business, firm, corporation, partnership, enterprise or organization that
      competes with the business engaged or hereafter engaged in by the Company;
      (B) the sale, trade, service or production or attempted sale, trade,
      service or production of genomics. (C) the sale, trade, service or
      production or attempted sale, trade, service or production of products
      which are competitor products to the products produced, sold or designed
      by the Company facility in Research Triangle Park, North Carolina during
      his employment with the Company; and (D) employment, whether direct or as
      independent contractor, with Metabolon, Beyond Genomics, SurroMed,
      Phenomenome, Metabometrix, or Cantata, and any of their successor
      businesses or businesses which acquire these companies after the date of
      this Agreement.

5.    Executive for twelve (12) months immediately following the date of this
      Agreement, shall not recruit or encourage employees of Paradigm to leave

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      paradigm to be hired by any company or business with which he affiliated
      or allow any such company or business, to the extent it is in his control,
      to engage in any activity which, were it done by him, would violate any
      provision of this Section 8; provided, however, that the Company
      acknowledges and agrees that a company or business with which you are
      affiliated may employee or engage Paradigm employees that have left
      Paradigm, so long as the company or business did not recruit or encourage
      the Paradigm employee to leave (it being understood that discussions,
      whether occurring before or after the date of this Agreement, resulting
      from general employment advertisements or initiated by Paradigm employees,
      do not constitute recruitment or encouragement to leave.

6.    The parties agree that Paradigm has no prior legal obligations to provide
      the additional monetary payments and other benefits specified in Paragraph
      3, which are exchanged for Executive's promises and agreements herein.

7.    Executive agrees that the only consideration for signing this Agreement
      are the terms stated herein and that no other promises or assurances of
      any kind have been made to him by Paradigm, its attorneys, or any other
      person as inducement to sign this Agreement. Therefore, this Agreement
      constitutes the entire understanding of the parties, and no
      representation, promise or inducement not included herein shall be binding
      upon the parties.

8.    Executive agrees that he will not disclose matters relating to the
      contents of this Agreement, including the amount of monetary payments and
      other benefits, to anyone other than his spouse, attorneys, and
      accountants or financial advisors for professional counseling. Executive
      also agrees that he will take every precaution to ensure that his spouse,
      attorneys, accountants or financial advisors maintain the confidentiality
      provisions of this Agreement before any disclosure is made as permitted by
      this paragraph.

9.    Executive understands and agrees that Paradigm's obligation to perform
      under this Agreement is constituted upon Executive's performance of all
      agreements, releases, and covenants to Paradigm as set forth herein.

10.   Executive acknowledges that he possesses sufficient education and
      experience to fully understand the terms of this Agreement as it has been
      written, the legal and binding effect of this Agreement, and the exchange
      of monetary payments and other benefits for promises herein.

11.   This Agreement shall endure to and be binding upon the parties hereto, the
      respective heirs, legal representatives, successors, and assigns.

12.   This Agreement is made and entered into in the State of North Carolina and
      shall in all respects be construed, enforced, and governed in accordance
      with the laws of North Carolina, except as federal laws may apply.

13.   In the event that one or more of the provisions, or portions thereof, of
      this Agreement is determined to be illegal or unenforceable, the remainder
      of this Agreement shall not be affected thereby, and each remaining
      provision or portion

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      thereof shall continue to be valid and effective and shall be enforceable
      to the fullest extent permitted by law.

14.   Executive states that he has carefully read the foregoing Agreement, that
      the terms are fully understood, and that he voluntarily accepts these
      terms and signs the same as his own free act.

      IN WITNESS WHEREOF, the parties have executed this Agreement on the day
and year first below written.

                                             PARADIGM GENETICS, INC.

                                             By: /s/ Heinrich Gugger
                                                -------------------------------
                                                  For Paradigm Genetics, Inc.

                                             Date: 11/20/02
                                                  -----------------------------

Accepted and agreed this 20th day of November, 2002.

 /s/  James D. Bucci
-----------------------------------------
      James D. Bucci

I acknowledge that I have been advised that I have up to forty-five (45) days to
consider this Agreement and I may revoke my agreement within seven (7) days of
signing.

                                             Date
----------------------------------               -------------------------
      James D. Bucci


ATTACHMENT A

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FORM OF RELEASE

1.    Executive hereby fully and expressly, knowingly, voluntarily and
      unconditionally releases, acquits, and forever discharges Paradigm, its
      past and present owners, stockholders, agents, directors, officers,
      employees, divisions, subsidiaries and affiliates, predecessors,
      successors and assigns (collectively referred to as Releasers) from any
      and all charges, complaints, claims, liabilities, obligations, promises,
      agreements, controversies, damages, actions, causes of action, rights,
      demands, losses, debts, expenses, and attorney fees and cost of any nature
      whatsoever, known or unknown, with regard to any transaction or event
      occurring prior to the date of this Agreement.

2.    Executive agrees and understands that this release includes, but is not
      limited to, all claims under Title VII of the Civil Rights act of 1964, 42
      U.S.C.Section 2000e, et. seq., as amended, the Americans with Disabilities
      Act of 1990, 42 U.S.C. Section 12101 et. seq., the Rehabilitation act of
      1973, 29 U.S.C. Section 701 et. seq., and all other federal or state laws
      and statutes or common law claims arising out of, or relating to his
      employment with Paradigm or with regard to any other transactions or
      events occurring prior to the date of this Agreement. Executive further
      agrees that he will not file, commence, prosecute or participate in any
      charge, claim, or lawsuit against Paradigm or any Releasers based on or
      arising from the matters released herein. Executive also agrees to
      indemnify and hold Paradigm harmless from any claims and expenses Paradigm
      may incur as a result of any failure by Executive to pay taxes, which may
      be due as a result of the payment by Paradigm herein.

3.    Executive further agrees and understands that this Agreement includes, but
      is not limited to, all claims under the Federal Age Discrimination and
      Employment Act of 1967, as amended, 29 U.S.C. Section 621, et. seq., and
      any other state or local laws concerning age discrimination, which may
      have arisen prior to the date of this Agreement. Executive acknowledges
      that he has been advised by Paradigm that he has up to forty-five (45)
      days to consider this Agreement and that he may revoke his acceptance of
      this Agreement within seven (7) days of signing. Further, Executive
      acknowledges that he is advised to consult with legal counsel of his own
      choice and at his own expense to seek clarification of any of the
      Agreement's terms prior to signing this Agreement.

4.    Executive agrees that he will not use for himself nor will he disclose to
      any other person, business, company or corporation any trade secret, data,
      knowledge or other proprietary information of or about Paradigm or its
      affiliates. Further, in accordance with normal ethical and professional
      standards, Executive will refrain from taking actions or making
      statements, written or oral, which disparage or defame the goodwill or
      reputation of Paradigm, its affiliates or their present/former directors,
      officers, executives, and employees, or make statements which could
      adversely affect the morale of other Paradigm employees. Furthermore,
      Paradigm agrees, when requested by a prospective employer for Executive
      that it will give a positive recommendation. Any reference requests must
      be referred to the Vice President, Human Resources.

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5.    Executive acknowledges and recognizes that his violation of this Agreement
      will cause Paradigm irreparable damage and Paradigm will have no adequate
      remedy at law for such violation. Accordingly, Executive agrees that
      Paradigm shall be entitled as a matter of right to an injunction out of
      any court of competent jurisdiction, restricting any further violation of
      the Agreement or covenants contained therein. Such right to injunctive
      relief shall be cumulative and in addition to any other remedies Paradigm
      may have at law, including the right to recover from Executive the entire
      amount paid to Executive under the Agreement Related to Severance between
      Executive and Paradigm, dated November 22, 2002. Nothing in this Agreement
      shall be construed to abridge or limit in any way Executive's ability to
      enjoy the benefits of this Agreement, nor shall any terms of this
      Agreement be construed to limit any resource, right or remedy at law or in
      equity, which Executive may have for breach thereof. Further, Executive
      hereby agrees to indemnify and hold Paradigm and each of the Releasers
      harmless from and against all loss, damage or expense, including without
      limitation, attorneys' fees and costs incurred by Paradigm, or any
      Releaser arising out of Executive's breach of this Agreement.

6.    This Agreement shall endure to and be binding upon the parties hereto, the
      respective heirs, legal representatives, successors, and assigns.

7.    This Agreement is made and entered into in the State of North Carolina and
      shall in all respects be construed, enforced, and governed in accordance
      with the laws of North Carolina, except as federal laws may apply.

8.    In the event that one or more of the provisions, or portions thereof, of
      this Agreement is determined to be illegal or unenforceable, the remainder
      of this Agreement shall not be affected thereby, and each remaining
      provision or portion thereof shall continue to be valid and effective and
      shall be enforceable to the fullest extent permitted by law.

9.    Executive further states that he has carefully read the foregoing
      Agreement, that the terms are fully understood, and that he voluntarily
      accepts these terms and signs the same as his own free act.


      IN WITNESS WHEREOF, the parties have executed this Agreement on the day
and year first below written.

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                                             PARADIGM GENETICS, INC.

                                             By:
                                                -------------------------------
                                                  For Paradigm Genetics, Inc.


                                             Date:
                                                  -----------------------------

Accepted and agreed this ______ day of November, 2002.


-----------------------------------------
      James D. Bucci

I acknowledge that I have been advised that I have up to forty-five (45) days to
consider this Agreement and I may revoke my agreement within seven (7) days of
signing.

                                             Date
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        James D. Bucci