exv10w31



 





Exhibit 10.31



EXCLUSIVE LICENSE AND SPONSORED RESEARCH AGREEMENT




between




OMEROS CORPORATION and MEDICAL RESEARCH COUNCIL




     This license agreement (the “Agreement”) is made effective the 31st day of October 2005 (the
“Effective Date”) between Omeros Corporation, a Washington corporation having a principal place of
business at 1420 Fifth Avenue, Suite 2600, Seattle WA 98101 USA (“Omeros”) and Medical Research
Council, a United Kingdom governmental institution having a place of business at 20 Park Crescent,
London, United Kingdom, W1B 1AL (“MRC”).



     WHEREAS MRC owns rights to certain technology related to mannan-binding lectin associated
serine protease-2 (“MASP-2”), which technology was developed in part by Anthony C. Willis (“Mr.
Willis”) working in an MRC laboratory under the direction of Professor Kenneth B. M. Reid (“Dr.
Reid”), both employees of MRC;



     WHEREAS Omeros holds an exclusive, worldwide license to rights owned by the University of
Leicester (“Leicester”) related to the MASP-2 technology due to the development in part of the
MASP-2 technology by Leicester’s employees;



     WHEREAS Omeros wishes to undertake an exclusive license to MRC’s rights in the MASP-2
technology, and to sponsor further research by MRC to develop the MASP-2 technology at MRC, under
the direction of Dr. Reid, working in collaboration with Omeros and Leicester; and



     WHEREAS MRC wishes to grant Omeros an exclusive license in MRC’s rights to the MASP-2
technology in return for potential royalty payments and sublicense revenue sharing, and to accept
payment for such sponsored research;



     NOW THEREFORE, in consideration for the mutual covenants and obligations set forth herein as
well as other good and valuable consideration, the parties hereby agree as follows:




	1	 	Definitions
	 
	1.1	 	Reference to “MRC” and “Omeros” in regards to any intellectual property right developed by
the respective party shall be construed to refer to the respective party as well as the
respective party’s employees, officers, directors, consultants and agents.
	 
	1.2	 	“Intellectual Property Rights” shall mean all inventions, ideas, discoveries, issued,
reissued or reexamined patents, pending and future patent applications, continuation,
continuation-in-part and divisional patent applications, utility models, inventor’s
certificates, trade secrets, know-how, copyrights and trademarks.
	 
	1.3	 	“Sponsored Research” shall mean all research activities carried out by MRC and/or its
employees (as may be agreed by MRC and Omeros) with the financial sponsorship, in whole or in
part, by Omeros in accordance with Section 2 herein below or as otherwise agreed.







 




			
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	1.4	 	“MRC IP” shall mean all Intellectual Property Rights owned or held by MRC, including without
limitation all such Intellectual Property Rights arising from the work of Mr. Willis, Dr. Reid
and/or other MRC employees, prior to the Effective Date of this Agreement, or developed or
obtained by MRC after the Effective Date of this Agreement both (a) independently of Omeros
(as determined by inventorship under US law with respect to any patents and patent
applications) and (b) independently of the Sponsored Research, provided always that any of the
Intellectual Property Rights described above in this section 1.4 are directly related to
compositions, antibodies and/or methods for the inhibition of MASP-2 and/or the diagnosis
and/or treatment of MASP-2 mediated disorders and/or deficiency syndromes, as well as methods,
polynucleotides, polypeptides, sequences and tools related to the development and production
of MASP-2 antibodies, including without limitation murine, human, humanized and recombinant
antibodies, MASP-2 inhibitors, [†].
	 
	1.5	 	“Omeros IP” shall mean all Intellectual Property Rights owned or held by Omeros prior to the
Effective Date of this Agreement, or developed or obtained by Omeros after the Effective Date
of this Agreement independently of MRC (as determined by inventorship under US law with
respect to any patents and patent applications), including without limitation all such
Intellectual Property Rights (a) related to MASP-2 obtained by Omeros under license from
Leicester (including without limitation all MASP-2 and MAp19 rights conveyed under the
Omeros-Leicester Agreement of 10 June 2004) or developed by Omeros independently of MRC by
Omeros and (b) related to methods and pharmaceuticals or other agents to inhibit pain,
inflammation, cartilage loss, vasospasm, smooth muscle spasm, restenosis, or tumor cell
adhesion, and/or to accelerate recovery of joint motion and function, for use in surgical
procedures (including without limitation arthroscopic, cardiovascular, urologic and general
surgical procedures), other medical procedures, and/or for treatment of cartilaginous
disorders, and drug delivery methods and systems.
	 
	1.6	 	“Joint IP” shall mean (a) all Intellectual Property Rights in technology that is developed
jointly (as determined by inventorship with respect to any patents and patent applications) by
Omeros and MRC (as may be agreed by MRC and Omeros) during the Sponsored Research Term (as
that term is defined in Section 2.2 herein), and (b) all Intellectual Property Rights arising
from and as the direct result of the Sponsored Research. Joint IP may or may not also be
jointly developed with Leicester or other third party, which will not change the nature of the
Intellectual Property Rights as Joint IP so long as the first sentence of this Section
applies. Should any MRC employee enter into a consulting agreement with Omeros for general
scientific consulting such as in the field of inflammation, then to the extent that such
scientific consulting services may pertain to MASP-2, the results of such scientific
consulting services will be treated as part of the Joint IP. However, the parties acknowledge
herein that research by MRC employees on behalf of Omeros related to MASP-2 will be carried
out in major part through the Sponsored Research.







 




			
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	1.7	 	[†]
	 
	1.8	 	“Licensed Products” shall mean all antibodies, inhibitors and all other products that, were
it not for the license granted to Omeros under this Agreement, infringe, or the use,
manufacture, offer for sale or sale of which infringe any valid and subsisting claim(s) of any
issued patent or any patentable claim(s) of any pending patent application included within the
MRC IP in the country or countries in which such products are offered for sale, sold,
manufactured or used, excluding all products that would be included within the Licensed
Products in accordance with the above definition only because they are products that [†].
	 
	1.9	 	“Net License Proceeds” shall mean the total of the gross monetary amounts invoiced and
collected by Omeros for Licensed Products (or that portion of the value of any combination
product attributed to a Licensed Product included therein) used, manufactured, directly sold
or directly distributed by Omeros, less (a) the sum of the following actual and customary
deductions where applicable: cash, trade, or quantity discounts; sales, use, tariff,
import/export duties or other excise taxes, and any other governmental taxes imposed on
particular sales; transportation charges and allowances; commissions to third party sales
agents; and credits to customers because of rejections or returns and (b) any accrued Omeros
IP Legal Fees (as defined below) not previously deducted. For purposes of this paragraph, the
acquisition of Licensed Products from Omeros as part of an acquisition of all or a substantial
part of the assets of Omeros’ business to which this Agreement pertains shall not be
considered a manufacture, sale or distribution.
	 
	1.10	 	“Net Sublicense Proceeds” shall mean the total of all sublicense royalties or sublicense fees
received by Omeros from third parties to which Omeros grants a sublicense under the MRC IP for
the manufacture, sale or distribution of Licensed Products, and which were not included in the
Net License Proceeds, less any accrued Omeros IP Legal Fees not previously deducted, provided
however that the Net Sublicense Proceeds shall not include any fees or payments from such
third parties to Omeros to support research and development efforts, to purchase equity in
Omeros, or for any other purpose other than as compensation for sublicense rights.
	 
	1.11	 	“Omeros IP Legal Fees” shall mean the sum of all legal fees and costs incurred by Omeros to
(a) evaluate, apply for, prosecute and maintain any Intellectual Property Rights included
within the MRC IP, including without limitation any such fees and costs paid by Omeros as
reimbursement to MRC for such fees and costs incurred by MRC, and (b) obtain or assist MRC in
obtaining or attempting to obtain clear, defensible, lawful and uncontested title to the MRC
IP, including without limitation all such fees and costs incurred in [†].
	 
	1.12	 	“Third Party License Fees” shall mean all royalties or other fees paid by Omeros to third
parties for a license from such third parties under Intellectual Property Rights owned or held
by such third parties for the manufacture, use, offer for sale, sale or distribution of
Licensed Products, but shall exclude that portion of any such third party royalties







 




			
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	 	 	(including without limitation royalties
payable to Leicester) or other fees paid by
Omeros attributed to items sold in
combination with the Licensed Products,
which items are not Licensed Products.
	 
	2	 	Sponsored Research
	 
	2.1	 	MRC shall perform research to be conducted by or under the direction of Dr. Reid and another
MRC senior research investigator (the “MRC Co-investigator”) working under the direction of
Dr. Reid as may be agreed between MRC and Omeros (Dr. Reid and the MRC Co-investigator
collectively “MRC Investigators”), directed to advancing the technology included in the MRC IP
or related technology concerning the characterization and inhibition of MASP-2, supported by
the financial sponsorship of Omeros, and without the use of third party sponsorship that would
provide any intellectual property rights in the results of the Sponsored Research to such
third party, in accordance with one or more research plans (“Research Plans”) agreed to in
advance in writing between MRC and Omeros. An initial Research Plan is attached hereto as
Exhibit A. The Research Plans may involve collaborative research efforts by Omeros, MRC
and/or Leicester as may be agreed between MRC and Omeros. No Research Plan or any amendment
thereto shall be effective until executed by MRC and Omeros, and upon mutual execution shall
be automatically incorporated into this Agreement. Each Research Plan shall define scientific
aims, objectives and activities, a budget and a timeline for performance of Sponsored Research
during the corresponding time period.
	 
	2.2	 	The Sponsored Research shall be completed over a term (the “Sponsored Research Term”) of
thirty four months (34 months) commencing 1 November 2005 or as may otherwise be mutually
agreed in writing. If Omeros or MRC wishes to terminate the Sponsored Research Term early,
such party shall provide the other party notice of non-extension at least ninety (90) days
prior to the end of any given year of the Sponsored Research term, i.e., by 3 August of such
year. In the event of a breach of this Agreement by MRC during the Sponsored Research Term,
Omeros may terminate the Sponsored Research Term as provided in accordance with Section 14.4
below at its sole discretion, without penalty. If Omeros should terminate the Sponsored
Research Term as provided in accordance with Section 14.4 below for any other reason before
completion of the full Sponsored Research Term, or upon completion of the full Sponsored
Research Term, Omeros will reimburse MRC for any legally required severance payable to the MRC
Co-investigator due solely to the termination or conclusion of the Sponsored Research, not to
exceed [†], provided, however that MRC will utilize its best efforts to minimize or avoid the
need for any such payment, including without limitation efforts to find other support for the
MRC Co-investigator, and provided further that MRC shall provide Omeros with documentation of
the legal requirement for and amount of any such severance. The Sponsored Research Term shall
run independently of the License Term (as defined herein below) of this Agreement.
Termination of this Agreement shall result in termination of the Sponsored Research Term, but
termination of the Sponsored Research Term, such as in accordance with this Section 2.2 or
Section 14.4 herein, shall not affect the overall status of this Agreement or the License
Term.







 




			
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	2.3	 	MRC shall supply all necessary personnel, administrative management, facilities, equipment
and supplies to enable timely completion of the Sponsored Research, including both of the MRC
Investigators, for the duration of the Sponsored Research Term. Reimbursement for MRC’s costs
and expenses for the Sponsored Research shall be provided only to the extent agreed to in
writing in the applicable Research Plan. Each Research Plan will be completed diligently by
MRC using best efforts in accordance with prevailing professional standards and all applicable
laws, regulations and MRC’s official policies. Should the MRC Investigators become
unavailable to complete any Research Plan, MRC and Omeros may agree on a substitute
investigator, and in the event that a mutually acceptable substitute is not available, either
party may terminate the Sponsored Research Term.
	 
	2.4	 	Within thirty (30) days of the end of each quarter of the Sponsored Research Term, MRC shall
submit a status report in written and electronic form (“Status Report”) summarizing the
results of the research completed during that quarter, except that annually within thirty (30)
days of the end of each year of the Sponsored Research Term or at such other point in time as
may be mutually agreed in writing, MRC shall submit a final status report in written and
electronic form (“Final Report”) detailing the results of the research completed during such
year of the Sponsored Research Term. Upon Omeros’ request, MRC shall complete all requested
corrections and make reasonable revisions to each Status Report and/or Final Report to place
it into a form suitable to meet Omeros’ objectives, including potential use of any Status
Report and/or any Final Report as part of any regulatory submissions.
	 
	2.5	 	In full and complete consideration for the Sponsored Research completed by MRC during the
Sponsored Research Term in accordance with the Research Plan(s), Omeros shall pay MRC a total
of [†] over the Sponsored Research Term in accordance with the annual schedule set forth in
Exhibit A, unless the Sponsored Research Terms is terminated earlier in accordance with the
provisions of this Section 2, in which case no further scheduled payments shall be payable, or
unless a change in the level of Sponsored Research work is agreed to in writing in subsequent
Research Plans, and subject to the following potential adjustment based on the British
national pay scale. The salary portion of the compensation amount payable during each year
includes a projected increase for changes in the British national standard pay scale, and
shall be adjusted up or down annually to reflect actual changes in the British national
standard pay scale. Compensation for each year of the Sponsored Research Term shall be
payable at the rate of twenty five percent (25%) of the annual amount per quarter, with a
first quarterly payment due and payable upon the start of the year, second and third quarterly
payments due and payable four and eight months, respectively, from the start of the year, and
a fourth quarterly payment due and payable upon the later of the end of the year or acceptance
of a Final Report for such year; provided, however, that no payment shall be due for any
quarter prior to the receipt and acceptance by Omeros of a Status Report or any Final Report,
as appropriate, for the respective quarter or year. All undisputed payments that have become
due and payable shall be paid within thirty (30) days of receipt of an invoice from MRC.







 




			
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	2.6	 	Omeros and the MRC Investigators shall collaborate on any proposed scientific publications of
Sponsored Research data and results, including a discussion of authorship and contents. MRC
shall furnish Omeros with copies of any publication or written or oral disclosure that is
proposed by MRC, including, without limitation, disclosures in papers or abstracts or at
research seminars, lectures, professional meetings, or poster sessions, at least sixty (60)
days prior to the proposed date for submission for publication or disclosure. During such
60-day period, Omeros shall have the right to review and comment on such publication for
accuracy and protection of confidential information. Additionally, upon Omeros’ written
request during the foregoing 60-day period, the proposed submission for publication or
disclosure shall be delayed until Omeros has completed the filing of patent applications
directed to information contained in such proposed publication or disclosure or based on
Omeros’ reasonable determination that publication should be delayed due to other business
considerations, but in no event will such delay exceed an additional ninety (90) days
following the initial 60-day period without MRC’s written consent, which consent shall not be
unreasonably withheld. Omeros shall have the right, in its sole discretion, to use, disclose,
disseminate and publish (with due acknowledgement of authorship) all data and results arising
out of the Sponsored Research for any and all purposes, including without limitation in and
for submissions to any regulatory agencies and in marketing any products including, but not
limited to, Licensed Products.
	 
	3	 	Ownership of Intellectual Property
	 
	3.1	 	All MRC IP shall remain owned or held by MRC to the same extent as would be the case were it
not for this Agreement.
	 
	3.2	 	All Omeros IP shall remain owned or held by Omeros to the same extent as would be the case
were it not for this Agreement.
	 
	3.3	 	All Joint IP shall be jointly owned by Omeros and MRC, i.e., Omeros and MRC each shall hold a
50% undivided joint ownership interest in all Joint IP, provided however that Omeros and MRC
recognize that third party collaborators such as Leicester may also have an ownership interest
in intellectual property included in the Joint IP, which third party ownership interest shall
not be impacted or determined by this Agreement.
	 
	4	 	Grant Of License
	 
	4.1	 	MRC hereby grants to Omeros for the term of this Agreement a royalty-bearing,
world-wide exclusive license in the MRC IP for the research, development, manufacture, use,
sale, offering for sale, distribution, exportation and importation of any and all products and
the practice of all methods within the MRC IP, including without limitation the exclusive
right to develop, manufacture, use, sell, offer for sale, distribute, export and import the
Licensed Products for all purposes including without limitation the research, development and
production of antibody or other MASP-2 inhibitor products.
	 
	4.2	 	MRC hereby grants to Omeros a fully paid-up, irrevocable, world-wide exclusive license
in and to MRC’s joint ownership interest in the Joint IP, for the manufacture, use, sale,







 




			
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		 	offering for sale, distribution, exportation and importation of any and all products and the
practice of all methods encompassed by the Joint IP.
	 
	4.3	 	Subject to publication approval and timing procedures consistent with Section 2.6
herein, MRC shall retain the right to use the MRC IP and the Joint IP for the purpose of
conducting non-commercial, academic research, including research sponsored by not-for-profit
entities, which shall not include the performance of research sponsored (directly or
indirectly) by or on behalf of any for-profit entity that is in direct competition with Omeros
in a technology, product or research tool that is the subject of the MRC IP or Joint IP.
	 
	4.4	 	Omeros shall have the right to grant sublicenses in the MRC IP and the Joint IP under
this Agreement subject, with respect to the MRC IP, to Omeros’ obligations to share sublicense
revenues as set forth in Section 5.
	 
	4.5	 	As part of the licenses granted to Omeros under Sections 4.1 and 4.2, MRC agrees to
transfer and provide and/or make available to Omeros upon request biological materials and any
other research materials and know-how encompassed by or included within the MRC IP and/or the
Joint IP to which MRC has appropriate rights and access, all such materials being provided on
the basis of Omeros reimbursing MRC for MRC’s actual cost in providing such materials but for
no additional consideration.
	 
	4.6	 	MRC also grants to Omeros a right of first refusal for an exclusive license in all of MRC’s
Intellectual Property Rights, for which Omeros has not already been granted a license
hereunder, and for which MRC has all necessary rights to offer such first refusal, and MRC
shall exert reasonable efforts to obtain such necessary rights, in (1) any commercially
applicable technology that arises during the Term of this Agreement and is directly related to
MASP-2 as more fully defined in the MRC IP and the Joint IP, and (2) any technology that has
been developed through the contribution of both Omeros and MRC after the Sponsored Research
Term.
	 
	5	 	Royalties and Sublicense Revenue
	 
	5.1	 	Omeros shall pay MRC on a quarterly basis a royalty for Licensed Products of [†] of that
portion of the Net License Proceeds realized during each respective quarter from Licensed
Products (the “Licensed Product Royalty”). Not withstanding the above, if the total royalties
owed by Omeros to all parties for Licensed Products, including without limitation the Licensed
Product Royalty payable to MRC, royalties payable to Leicester, [†] and any “stacking fee(s)”
or other royalties payable to third parties to develop, manufacture or commercialize the
Licensed Products (all together the “Total Royalty Percentage”), exceeds [†] of the Net
Licensed Proceeds for any quarter, then [†] of the difference between the Total Royalty
Percentage and [†] shall be deducted from the Licensed Product Royalty payable to MRC for such
quarter, provided, however that the Licensed Product Royalty for such quarter may not be
reduced by such deductions to less than [†].
	 
	5.2	 	Omeros shall pay MRC on a quarterly basis a share of that portion of the Net Sublicense







 




			
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	 	 	Proceeds collected by Omeros on Licensed Products and collected by Omeros (“Sublicensed
Product Revenue Share”) from sublicensed third parties during each respective quarter, such
Sublicensed Product Revenue Share being either (a) [†] for any sublicenses in connection
with the Licensed Products granted hereunder prior to the earlier of (i) the establishment
of MRC’s clear, defensible, lawful and uncontested title in, or other mutually acceptable
rights relative to, [†], or (ii) the second year anniversary of the Effective Date of this
Agreement, or (b) [†] for any sublicenses in connection with the Licensed Products granted
hereunder thereafter.
	 
	5.3	 	Omeros shall promptly provide MRC with a copy of all sublicenses granted by Omeros in the MRC
IP and/or the Joint IP under this Agreement.
	 
	5.4	 	Following receipt from the University of the results of all Sponsored Research and the
completion of all other necessary and beneficial research activities by Omeros and/or by
others to support appropriate government regulatory submissions by
Omeros, [†], Omeros shall
use reasonable efforts, based on reasonable commercial prudence, to diligently develop and
introduce to the market one or more Licensed Products. Ongoing performance of research and/or
development efforts to generate or further advance one or more Licensed Products by Omeros,
internally at Omeros and/or under contract with MRC and/or a third party, shall be deemed to
be diligent efforts under this Section 5.4.
	 
	5.5	 	It is Omeros’ current intent to commercially develop and seek regulatory clearance to
clinically test and then market an inhibitor of MASP-2 activity following identification of
selective and high-affinity inhibitors of MASP-2 activity and demonstration of the therapeutic
benefit of such inhibitors in animal models, such identification and demonstration to be
completed collaboratively by MRC, Leicester and/or Omeros. Within three months of the
identification by Omeros of a Licensed Product that is determined by Omeros to be a viable and
optimal clinical development candidate, Omeros will submit a development plan to MRC that sets
forth Omeros’ planned activities and estimated timing for the development, regulatory approval
and market introduction of one or more Licensed Products. Assuming anticipated and adequate
progress is made in the Sponsored Research [†], Omeros anticipates the identification of an
initial potential candidate for a Licensed Product or Licensed Research Product that is a
potential clinical development candidate within two years of the commencement of the Sponsored
Research. The foregoing statements within this Section 5.5 and such development plan are or
will be provided as indications of current or future intentions only, and shall have no
binding effect on Omeros, nor shall it give rise to any right or obligation to either party,
and any modification, alteration or failure to meet any of these intentions shall have no
impact on this Agreement.
	 
	6	 	Payments
	 
	6.1	 	Quarterly royalty and sublicense revenue payments shall be made in British Pounds Sterling by
Omeros to MRC within sixty (60) days of the end of the quarter. Payments shall be computed
based on a conversion from any other denomination to British Pounds Sterling for any revenues
received or costs and expenses incurred by Omeros during the







 




			
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	 	 	relevant quarter or other reporting period, as provided herein, using the prevailing
exchange rate in effect at the date and time that funds are transferred from Omeros’ account
to MRC’s account (in the case of payment by wire transfer) or at the date and time of
issuance of a check by Omeros (in the case of payment by check). Each quarterly payment
shall be accompanied by a report specifying (a) the source of the royalties itemized by
product and country, (b) any Omeros IP Legal Fees or Third Party License Fees that were
deducted from gross proceeds to determine Net License Proceeds or Net Sublicense Proceeds as
provided in Sections 1.9 or 1.9 of this Agreement, and (c) the total of all discounts,
returns, credits and commissions deducted from gross proceeds to determine Net License
Proceeds or Net Sublicense Proceeds as provided in Sections 1.9 or 1.9 of this Agreement.
Following the two-year anniversary of the Effective Date of this Agreement, in the event
that Omeros receives no such quarterly royalty and sublicense revenue in any given quarter,
it shall nevertheless submit a quarterly report to that effect to MRC within sixty (60) days
of the end of the quarter.
	 
	6.2	 	MRC reserves the right to employ a certified public accountant to review and reconcile the
directly relevant accounting records and procedures of Omeros as they relate to the
determination of royalties or sublicense revenue fees under Section 5 herein during reasonable
business hours and no more than twice a year, and Omeros agrees to make available at Omeros’
place of business all such directly relevant accounting records for that purpose within 30
(thirty) days of written request by MRC. The cost of such review shall be borne by MRC,
unless it is found that Omeros under-paid a quarterly royalty or sublicense revenue fees for
any quarter by an amount of 10% (ten percent) or greater, in which case the cost of such
review shall be borne by Omeros.
	 
	6.3	 	In the event any royalty or sublicense revenue fee payments due under Section 5 herein are
not timely paid by Omeros, Omeros shall pay to MRC interest charges on such late payments at a
rate of [†].
	 
	6.4	 	Not withstanding anything to the contrary herein, Omeros shall have no obligation to pay any
royalties or sublicense revenue fees under Section 5 for any product based on any patent claim
that has been declared invalid or unenforceable by a court or governmental body of competent
jurisdiction or based on any patent claim that is not enforceable in the jurisdiction(s) where
such products are manufactured, used, sold, offered for sale, imported or distributed.
	 
	7	 	License Progress
	 
	7.1	 	Omeros shall on an annual basis, commencing on the one-year anniversary of the Effective Date
of this Agreement and annually thereafter, deliver to MRC within thirty (30) days after the
end of the respective year a written progress report detailing the status of Omeros’ efforts
to fund, patent, develop and commercialize Licensed Products.
	 
	8	 	Patent Prosecution
	 
	8.1	 	Omeros shall have the sole right at its discretion to apply for, prosecute and maintain
patents for inventions included within the MRC IP and the Joint IP (“Patent Filings”) in







 




			
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	 	 	the name of the legally appropriate inventors and/or parties to this agreement and/or
jointly with third parties as may be legally appropriate, provided however that (a) Omeros
shall bear all cost and expense for all such Patent Filings, subject to the right to deduct
Omeros IP Legal Fees as set forth herein, (b) Omeros shall keep MRC timely informed of the
progress of all Patent Filings and timely provide MRC copies of all official documentation
related to such Patent Filings, and (c) Omeros shall exert commercially reasonable efforts
to diligently pursue all Patent Filings to issuance or final determination of
unpatentability, provided however that if Omeros determines at its sole discretion to not
make Patent Filings for any commercially significant inventions within the MRC IP or the
Joint IP in any countries of commercial significance, or abandons any Patent Filing prior to
issuance or final determination of unpatentability, Omeros shall give MRC advance written
notice of such determination, MRC shall have the right thereafter to elect upon written
notice to Omeros to pursue such Omeros abandoned Patent Filings at MRC’s sole expense
(together with Leicester if applicable), and such Omeros abandoned Patent Filings shall be
excluded from the scope of the licenses granted under this Agreement.
	 
	8.2	 	MRC shall promptly provide written disclosure to Omeros of any inventions, improvements, or
applications included within the MRC IP or Joint IP conceived, developed, made or arising
before or during the term of this Agreement. MRC will provide all reasonable assistance,
including review of documents and the execution of all documents and causing MRC’s employees
to review and execute all documents, necessary to make, prosecute, maintain and enforce the
Patent Filings, all for no additional consideration but with reimbursement by Omeros of MRC’s
reasonable expenses for such assistance.
	 
	8.3	 	MRC shall promptly provide written disclosure to Omeros of any and all potentially material
prior art known prior to the Effective Date of this Agreement or that becomes known during the
License Term of this Agreement to any MRC employee that is associated with this Agreement, the
Sponsored Research, the MRC IP or the Joint IP.
	 
	9	 	Representations, Warranties and Other Obligations of Omeros
	 
	9.1	 	Omeros represents and warrants that it has the requisite corporate power and authority and
the legal right to enter into this Agreement and to perform its obligations hereunder.
	 
	9.2	 	Omeros has and will maintain reasonably adequate insurance coverage for employment practices
and general liability for all its activities under this Agreement. Prior to Omeros’ marketing
of any Licensed Product, or product encompassed by the Joint IP, or making any such products
available for use in any human patients, Omeros will obtain and maintain reasonably adequate
product liability insurance.
	 
	10	 	Representations, Warranties and Other Obligations of MRC
	 
	10.1	 	MRC has disclosed to Omeros the existence of the [†] and information as to the development of
the MRC IP, and MRC warrants that it has made reasonable efforts to ascertain the details of
such development and that it reasonably believes the same to be true. [†].








 




			
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	10.2	 	[†]
	 
	10.3	 	[†]
	 
	10.4	 	MRC represents and warrants, subject to the disclosure referred to in Section 10.1 with
respect [†] and to any rights owned by Leicester, that MRC is the owner of all other right,
title and interest in any and all inventions included within the MRC IP and the Joint IP made
or to be made wholly or jointly by MRC employees, including without limitation those made by
Mr. Willis and Dr. Reid, and shall cause Mr. Willis and Dr. Reid to each execute this
Agreement to confirm their agreement to be bound to the same extent as MRC with respect to all
relevant provisions of this Agreement.
	 
	10.5	 	Subject to [†] as discussed in Section 10.1 above and to any rights owned by Leicester, MRC
represents and warrants to Omeros that as far as it is aware, after having used reasonable
efforts to ascertain relevant facts and having formed a reasonable belief as to their truth,
it has the lawful right to grant the licenses conveyed under this Agreement, and that the MRC
IP and the Joint IP are unencumbered by any third party obligation, commitment, restriction or
license. [†]
	 
	10.6	 	[†] and any rights owned by Leicester, MRC warrants that it is not aware of any third party
rights that would be infringed as a result of Omeros’ fulfilling the terms of this Agreement.
	 
	10.7	 	MRC has and will maintain reasonably adequate insurance coverage for employment practices and
general liability for all its activities under this Agreement.
	 
	10.8	 	THE WARRANTIES SET FORTH EXPRESSLY IN THIS AGREEMENT ARE THE SOLE WARRANTIES
MADE BY EITHER PARTY TO THE OTHER AND THERE ARE NO OTHER WARRANTIES, REPRESENTATIONS OR
GUARANTEES OF ANY KIND WHATSOEVER, EITHER EXPRESS OR IMPLIED, REGARDING THE LICENSED PRODUCTS,
OR OTHER PRODUCTS, INCLUDING WITHOUT LIMITATION ANY EXPRESS OR IMPLIED WARRANTIES OF
MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE.
	 
	11	 	Confidentiality
	 
	11.1	 	MRC and Omeros hereby affirm and incorporate by reference the terms of the Mutual
Nondisclosure Agreement between the parties dated 9 May 2005 concerning the subject matter of
this Agreement, a copy of which is attached hereto as Exhibit B, except to the extent that the
terms of such nondisclosure agreement may conflict with the terms of this Agreement, in which
case the terms of this Agreement shall prevail. The parties further agree that the mutual
obligations of nondisclosure and non-use set forth in such Mutual Nondisclosure Agreement
shall subsist for a period of five (5) years after the termination of this Agreement.







 




			
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	11.2	 	The terms of this Agreement shall be maintained in strict confidence by both MRC and Omeros,
and may not be disclosed by either party without the consent of the other party, except as may
be required under a court order or decree or as required to comply with any governmental law,
rule or regulation, and Omeros may disclose the terms of this Agreement to Omeros’ current and
potential employees, directors, consultants, shareholders, investors and corporate partners.
	 
	12	 	Indemnification
	 
	12.1	 	Each party (the “Indemnifying Party”) shall indemnify, hold harmless and defend the other
party and its employees, officers, directors, consultants and agents (the “Indemnified Party”)
against any and all claims, suits, losses, liabilities, damages, costs, fees, and expenses
(“Claims”) resulting from or arising directly out of the Indemnifying Party’s breach of any
representation, warranty or obligation under this Agreement, or the Indemnifying Party’s
exercise of the rights and obligations under this license or any sublicense, except that such
obligation to indemnify, hold harmless and defend shall not extend to any Claims to the extent
such Claims result from or arise directly from the negligence or misconduct of the Indemnified
Party. This indemnification does not include any indemnity in relation to product performance
or product liability, and furthermore does not include any incidental, consequential or
special damages.
	 
	13	 	Enforcement of Patent Rights
	 
	13.1	 	If either party learns of the infringement of any patent or other intellectual property right
included in the MRC IP or the Joint IP, that party shall promptly notify the other party of
such infringement and will provide the other party with all evidence of infringement in the
notifying party’s possession. Both parties shall use their best efforts in cooperation with
each other to terminate third party infringement without litigation.
	 
	13.2	 	Omeros shall have the sole right at its discretion to enforce the MRC IP and the Joint IP
against third party infringers, including the initiation of any civil action in Omeros’ name,
at Omeros’ sole cost, in which event any award, judgment, settlement or damages collected
shall belong solely to Omeros without duty to account to MRC. In the event that it is
necessary for Omeros to join MRC as a party to any such civil action, MRC shall join such
action for no additional compensation but at Omeros’ sole expense, and any award, judgment,
settlement or damages collected shall belong solely to Omeros without duty to account to MRC.
	 
	13.3	 	If Omeros unreasonably declines to initiate enforcement of the MRC IP and the Joint IP
against any third party infringer within ninety (90) days of a written demand from MRC to do
so, then MRC shall have the sole right at its discretion to enforce the MRC IP and the Joint
IP against such third party infringer, including the initiation of any civil action in MRC’s
name, at MRC’s sole cost, in which event any award, judgment, settlement or damages collected
shall belong solely to MRC without duty to account to Omeros.
	 
	14	 	Term and Termination







 




			
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	14.1	 	Unless terminated earlier as set forth in Section 14.2 or 14.3 herein below, this Agreement
shall subsist so long as there is any pending patent application within the MRC IP or the
Joint IP, any patent application in the process of being prepared for filing as agreed to by
Omeros and MRC or any valid and subsisting claim included within any patent, utility model or
inventor’s certificate within the MRC IP or the Joint IP (the “License Term”).
	 
	14.2	 	Omeros may terminate this Agreement by providing ninety (90) days advance written notice of
termination under this Section 14.2 to MRC, with or without cause, at any time [†].
	 
	14.3	 	Either party may terminate this Agreement at any time in the event that the other party
(a) breaches any material obligation of this Agreement by first submitting written notice of
breach to the breaching party, which breach is not substantially cured within ninety (90)
days of the receipt of such notice, followed by written notice of termination then being
sent to the breaching party, or (b) declares or is adjudged by a court of competent
jurisdiction to be insolvent, bankrupt or in receivership, and such insolvency, bankruptcy
or receivership materially limits such party’s ability to perform its obligation under this
Agreement, excluding reorganizations entered into by such party with the consent of the
other party, which consent shall not be unreasonably withheld.
	 
	14.4	 	Omeros may at any time terminate its sponsorship of the Sponsored Research by providing
ninety (90) days advance written notice of termination under this Section 14.4 to MRC, for
cause as specified in Section 2.2 above or at any time due to failure to perform any Research
Plan or other breach of this Agreement by MRC, or without cause as specified in, and subject
to reimbursement of any severance fees that may be payable in accordance with, Section 2.2
above, in which event Sections 2.1 — 2.3 herein shall cease to be effective, and Sections 2.4
and 2.5 shall cease to be effective after all reports are provided and accepted and all
payments are made for Sponsored Research performed in accordance with the applicable Research
Plan prior to such notice, but the remainder of this Agreement shall continue in full force
and effect for the License Term, including all rights and obligations of both parties
hereunder. In the event of Omeros’ termination of its sponsorship of the Sponsored Research,
Omeros shall pay to MRC any and all non-cancelable sums reasonably incurred or committed to by
MRC prior to receipt of the notice of termination.
	 
	14.5	 	The provisions of Sections 2.6 (Publication), 3 (Ownership of Intellectual Property), 4.2 —
4.6 (License as applicable to Joint IP and right of first refusal), 8 (Patent Prosecution as
applicable to Joint IP), 9 and 10 (Representations and Warranties and Other Obligations), 11
(Confidentiality), 12 (Indemnification), 13 (Enforcement as applicable to Joint IP), 15 (Use
of Names) and 16 (Miscellaneous) above shall survive expiration or termination of this
Agreement for the period set forth therein or, if no period is set forth therein, then
indefinitely.
	 
	15	 	Use of Names
	 
	15.1	 	Nothing contained in this Agreement confers any right to either party to use in







 




			
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	 	 	advertising, publicity, or other
promotional activities any name, trade
name, trademark, or other designation
of the other party hereto, and neither
party shall make such use without the
prior written consent of the other
party, provided however Omeros may
through written, oral or electronic
communication disclose the existence
of this Agreement and the names of
MRC, Dr. Reid, Mr. Willis and other of
MRC’s employees and consultants to
Omeros’ current and potential
employees, directors, consultants,
shareholders, investors and corporate
partners, and as required to comply
with any governmental law, rule or
regulation.
	 
	16	 	Miscellaneous
	 
	16.1	 	This Agreement including all appendices and exhibits attached thereto or incorporated by
reference therein constitutes the entire understanding of the parties hereto regarding the
subject matter of this Agreement, and no other representation, agreement, promise or
undertaking altering, modifying, taking from or adding to the terms of this Agreement shall
have any effect unless the same is reduced to writing and duly executed by the parties hereto.
In the event of any conflict between the main body of this Agreement and any attachments
thereto or documents incorporated by reference therein, the provisions of the main body of
this Agreement shall control.
	 
	16.2	 	Either party’s failure to enforce any provision of this Agreement will not be considered a
waiver of future enforcement of that or any other provision.
	 
	16.3	 	The laws of the state of Delaware, United States, without regard to its conflict-of-laws
provisions, shall govern this Agreement, its interpretation and its enforcement, and any
disputes arising out of or related to this Agreement.
	 
	16.4	 	The parties agree that, except as provided herein below, any claim or controversy arising out
of or relating to this Agreement or breach thereof shall be settled by arbitration in the
state of Delaware, United States, in accordance with the commercial rules of the American
Arbitration Association by a panel of three arbitrators, one selected by each party and the
third selected by the other two arbitrators. In any such arbitration proceeding, judgment
upon the award rendered by the arbitrator shall be final and binding upon the parties and may
be entered by either party in any court or forum of competent jurisdiction as provided herein
below. Notwithstanding the foregoing, both parties agree that any claims or controversies
concerning the validity or enforceability of any intellectual property, or the actual or
threatened disclosure or misuse of confidential information, may alternately be resolved by a
civil action in any court of competent jurisdiction as provided herein below, and both parties
further agree that each shall retain the right to seek injunctive relief in any court of
competent jurisdiction as provided herein below to prevent a breach, threatened breach or
continuing breach of this Agreement which would cause irreparable injury (e.g., breaches of
confidentiality or the like).
	 
	16.5	 	Any civil action prosecuted or instituted by either party as permitted herein above with
respect to any matters arising out of or related to this Agreement shall be brought in either
the United States District Court located in the state of Delaware, United States (if







 




			
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	 	 	federal subject matter jurisdiction therein lies) or the Superior Court for the state of
Delaware, United States (if there is no subject matter jurisdiction in federal court), and
each party hereby consents to the jurisdiction and venue of such courts for such purposes.
	 
	16.6	 	In the event that it is necessary for either party of this Agreement to take legal action to
enforce any of the terms, conditions or rights contained herein, or to defend any such action,
then the prevailing party in such action shall be entitled to recover from the other party all
reasonable attorneys fees, costs and expenses related to such legal action.
	 
	16.7	 	In the event that any portion of this Agreement is held invalid or unenforceable by a court
of law, that provision will be construed and reformed to permit enforcement of the provision
to the maximum extent permissible consistent with the parties’ original intent, and if such
construction is not possible, such provision shall be struck from this Agreement, and the
remainder of the Agreement shall remain in full force and effect as if such provision had
never been part of this Agreement.
	 
	16.8	 	For the purposes of this Agreement, the parties hereto are independent contractors, and
nothing in this Agreement shall be construed to place them in the relationship of partners,
principal and agent, employer/employee or joint venturers. Except as provided expressly
herein, each party agrees that it shall have no authority to bind or obligate the other party,
nor shall any party hold itself out as having such authority.
	 
	16.9	 	Neither party will be liable for failure or delay in performing any obligation under this
Agreement, or will be considered in breach of this Agreement, if such failure or delay is due
to a natural disaster or any cause reasonably beyond such party’s control, provided that such
party resumes performance as soon as possible following the end of the event that caused such
delay or failure of performance.
	 
	16.10	 	Neither party may assign this Agreement, or any obligation or right under this Agreement, in
whole or in part, without the other party’s prior written consent, which consent will not be
unreasonably withheld. This Section shall not be construed in any way to limit Omeros’ rights
to grant, at Omeros’ sole discretion, sublicenses hereunder. MRC consents to Omeros’
assignment of this Agreement in whole or in part in connection with the merger, consolidation
or transfer of all or substantially all of that portion of Omeros’ assets to which this
Agreement relates. Subject to these restrictions, this Agreement will be binding upon and
will inure to the benefit of the parties’ permitted successors and assignees.
	 
	16.11	 	Any notice required or permitted to be given hereunder by either party shall be in writing
and shall be (a) delivered personally, (b) sent by registered mail, return receipt requested,
postage prepaid, (c) sent by an internationally recognized courier service guaranteeing
next-day delivery, charges prepaid, or (d) delivered by facsimile (with the original promptly
sent by any of the foregoing manners) to the addresses or facsimile numbers of the other party
set forth below, or at such other addresses as may from time to time be furnished by similar
notice by either party. The effective date of any notice hereunder shall be the date of
receipt by the receiving party.







 




			
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	 	If to Omeros:
	 	If to MRC:
	 
	 	 	 	 
	 

	 	Omeros Corporation
	 	Medical Research Council
	 

	 	1420 Fifth Avenue, Suite 2600
	 	20 Park Crescent
	 

	 	Seattle, WA 98101
	 	London
	 

	 	U.S.A.
	 	United Kingdom
	 

	 	 	 	W1B 1AL
	 
	 	 	 	 
	 

	 	Attention: Gregory A. Demopulos, M.D.,
	 	Attention: Graham Wagner,
	 

	 	                 Chairman & CEO
	 	Associate Director Licensing
	 

	 	 	 	and Agreements
	 
	 	 	 	 
	 

	 	And copy to: Marcia S. Kelbon,	 	 
	 

	 	          
           Patent & General Counsel	 	 
	 
	 	 	 	 
	 

	 	Fax: (206) 264.7856
	 	Fax: +44.207.291.5325
	 

	 	Phone: (206) 623.4688
	 	Phone: +44.207.291.5317







	16.12	 	This Agreement may be executed in one or more counterparts, each of which will be considered
an original, and all of which will constitute the same instrument.





     IN WITNESS WHEREOF, Omeros and MRC have each acknowledged and accepted this Agreement by
causing it to have been signed by their respective duly authorized officials.



	 	 	 	 	 	 	 	 	 
	OMEROS CORPORATION	 	MEDICAL RESEARCH COUNCIL	 	 
	 	 	 
	 	 	 	 	 	 
	By:
	 	/s/ Gregory A. Demopulos

	 	By:
	 	/s/ Graham Wagner	 	 
	 	 	 

	 	 	 	 	 	 
	Name:
	 	Gregory A. Demopulos, M.D.

	 	Name:
	 	Graham Wagner	 	 
	Title:
	 	Chairman & CEO

	 	Title:
	 	Associate Director Licensing and Agreements	 	 
	 
	Date:
	 	11/16/07

	 	Date:
	 	10th November 2005	 	 
	 
	Fax:
	 	206.264.7856

	 	Fax:
	 	+44 207 291 5325	 	 








 




			
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The above Exclusive License and Sponsored Research Agreement is acknowledged by the
undersigned investigators, who agree to abide by the terms set forth therein.



	 	 	 	 	 	 	 	 	 
	PROFESSOR KENNETH B. M. REID	 	MRC CO – INVESTIGATOR	 	 
	 
	 	 	 	 	 	 	 	 
	Signed:

	 	 	 	Signed:	 	 	 	 
	 

	 	 
	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Title:

	 	Director, MRC Immunochemistry Unit
	 	Title:	 	 	 	 
	 

	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Date:

	 	 	 	Date:	 	 	 	 
	 

	 	 
	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	Fax:

	 	 	 	Fax:	 	 	 	 
	 

	 	 
	 	 	 	 	 	 







 




			
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EXHIBIT A




To the Exclusive License and Sponsored Research Agreement




Between Omeros Corporation and the Medical Research Council




RESEARCH PLAN




Sponsor: Omeros Corporation




Research Institution: Medical Research Council (MRC)




Investigator: Dr. Ken Reid




Research Period: First year, commencing 1 November 2005




Research Aims and Activities




     Attachment 1 hereto sets for the research aims of the Sponsored Research program to be
completed during the first year. All activities to meet specific aim 1 are to be carried out by
MRC (“Dr. Reid’s lab”). Aims indicated as to be performed by Omeros or third parties, and all
animal models in specific aim 5, are provided herein for reference purposes only and shall not be
interpreted as any obligation on the part of Omeros or MRC. Specific aims and the corresponding
timeline may be modified as mutually agreed in writing by Dr. Ken Reid and Omeros.



Budget




     The total consideration to be paid to MRC for all Sponsored Research to be carried out during
the first through third years of the Sponsored Research Term, including without limitation full and
complete payment for all services, materials, facilities, overhead and indirect costs, but
excluding reimbursement for any legally required severance that may be payable as provided for is
Section 2.2 of this Agreement above, is as follows:




Year 1 (1 November 2005 — 31 October 2006):




[†]




Year 2 (1 November 2006 — 31 October 2007):




[†]




Year 3 (1 November 2007 — 31 August 2008):




[†]





 




			
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EXHIBIT B




To the Exclusive License and Sponsored Research Agreement




Between Omeros Corporation and Medical Research Council




MUTUAL CONFIDENTIALITY AGREEMENT






 




			
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