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### UNITED STA

**TES ENVIRONMENTA L PROTECTION A** **GENCY WA** **SHINGTON, D.C. 20460 OFFICE OF**  **CHEMICAL SAFETY AND**  **POLLUTION PREVENTION**  

### MEMORANDUM **DRAFT Date**  **: 10**  **/ 14**  **/ 2014**  **SUBJECT: Pendimethalin**  **:** Acute and Chronic Aggregate Dietary (Food and Drinking

Water) Exposure and Risk Assessment s in support of the Human Health Risk Assessment for New uses on Hops, Low Growing Berry Subgroups 13 - 07 G , Onion, bulb subgroup 3 - 07A, Onion, green subgroup 3 - 07B, and Sunflower Subgroup 20B; Crop Group conversions and expansions for Citrus Fruit Group 10, Pome Fruit Group 11, Stone Fruit Group 12, and Fruiting Vegetable Group 8. **PC Code:** 108501 **DP Barcode:** 416577 **Decision No.:** 484426 **Registration No. :**  241 - 245 **Petition No.: Regulatory Action**  **:** Risk Assessment **Risk Assessment Type:** Dietary **Case No.: T**  **XR No.:** NA **CAS No.:** 40487 - 42 - 1 **MRID No.: NA**  **40 CFR:** 40 CFR § 180 .361 **FROM:** P. Yvonne Barnes , Chemist

Risk A ssessment Branch (RABVI) Health Effects Division ( HED; 7509P) **THROUGH:** William D . Cutchin , Chemist

Thomas Bloem , Chemist Dietary Exposure Science Advisory Council (DESAC) **AND** Donna S. Davis, acting Chief RABVI

Health Effects Division (HED; mailstop 7509P) **TO:** Sidney

Jackson , Chemical Review Manager ( CRM ) Pesticide Re - evaluation Division (7805P)Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

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### Executive **Summary** A cut e and chronic aggregate dietary ( food and drinking water) exposure, and risk assessment s were conducted for pendimethalin using the Dietary Exposure Evaluation Model software with the Food Commodity

Intake Database (DEEM - FCID) Version 3.16 . This software uses 2003 - 2008 food consumption data from the U.S. Department of Agriculture’s (USDA’s) National Health and Nutrition Examination Survey , What We Eat in America, (NHANES/WWEIA). The se analys es were conducted in suppo rt of human health risk as sessment for the proposed establishing new crop subgroups based on the tolerance of existing individual commodities; existing crop conversions and expansions; section 3 new use on hop , dried cones . This memorandum was reviewed by two peer reviewers o f the DE SAC as per DESAC standard operating procedures ( SOP ) 2012.1 . Unrefined acute and chronic dietary exposure assessment s w ere conducted using tolerance - level residues for agricultural commodities, 100% crop treated, DEEM ® default or empirical processing factor s , and point estimate s for potential drinking water residues (NY Grape scenario) that produced the highest estimated drinking water concentrations ( EDWCs ) . Acute Dietary

Exposure Assessment The acute dietary

risk estimate for the highest exposed population subgroup, all infants is 1.7 % of the acute population adjusted dose ( aPAD) and for the general U. S. population is <1.0 % of the aPAD at the 95 th 

### percentile . HED is concerned when estimated dietary risk exceeds 100%. There are no acute dietary ri sk of concern. Chronic Dietary

Exposure Assessment The chronic dietary

risk estimate for the highest exposed population subgroup , children 1 - 2 years old is 1.7 % of the chronic population adjusted dose (c PAD ) and for the general U. S. population is <1.0 % of the cPAD. HED is concerned when estimated dietary risk exceeds 100% . There are no chronic dietary

risk of concern. Cancer Dietary

Exposure Assessment Pendimethalin is categorized as “ Group C, possible human carcinogen ." Quantification of risk using a non - linear approach; i.e., RfD /PAD , will adequatel y account for all chronic toxicity, including carcinogenicity, that could result from exposure to p endimethalin . **I. Introduction**  Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose that HED has concluded will result in no unreasonab le adverse health effects). This is referred to as the population - adjusted dose (PAD). The PAD is equivalent to the point of departure (P o D, NOAE L, L OAEL, e.g.) divided by the required uncertainty

or safety factors. For acute and non - cancer chronic expo sures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments inPendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

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### more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pes ticides, A User’s Guide,” 21 - JUN - 2000, W eb - link: http://www.epa.gov/fedrgstr/EPA - PEST/2000/July /Day- 12/6061.pdf or see SOP 99.6 (20 - AUG 1999). The most recent dietary

risk assessment for pendimethalin was conducted by Y. Barnes ( 0 5 /0 2 /20 1 2 , DP Number : D 401100 ). **II .**  **Residue Information** Pendimethalin (N - (1 - ethylprop yl ) - 3,4 - dimethyl - 2,6 - dinitrobenzenenamine) is a selective herbicide used for controlling annual grass and broadleaf weeds. It is a meristematic inhibitor that interferes with the plant’s cellular division of mitosis and is generally applied earl y in the growing season as a pre - emergent and early post - emergent herbicide . The agricultural uses of p endimethalin have been proposed for the aqueous capsule suspension formulation of the enduse product Prowl ® 

### H 2 

### O (38.7 % a.i.; EPA Reg istration Number: 241 - 418), a 3.8 lb s. a . i . /gallon liquid formulation. Prowl ® 

### H 2 

### O can be applied via ground and/or aerial application methods. The residues of concern in plant commodities , for tolerance enforcement and risk assessment purposes is pendimethalin and its 3, 5 - dinitrobenzyl alcohol metabolite ( DP# 329627, W. Drew, 07/12/2006 ) . The assessment assume d 100% crop treated. Currently , tolerances are established for the herbicide pendimethalin under 40 CFR: § 180.3 61 for newly p roposed subgroups based on existing tolerance for individual representative commodities: Lo w Growing Berry S ubgroups 13 - 07G (0.1 ppm) , Onion, bulb subgroup 3 - 07A (0.1 ppm) , Onion, green subgroup 3 - 07B (0.2 ppm) , and Sunflower Subgroup 20B (0.1 ppm) ; Crop Group conversions and expansions based on established crop group tolerance for Citrus Fruit Group 10 (0.1 ppm) , Pome Fruit Group 11 (0.1 ppm) , Stone Fruit Group 12 (0.1 ppm) , and Fruiting Vegetable Group 8 (0.1 ppm) . A new tolerance is proposed and recommended for Hop , dried cones (0.1 ppm). Empirical processing factors obtained from processing data were utilized for processe d commodities, when available and adequate residues ; in grape processed commodities are assumed to be the same as the raw commodity . DEEMTM 7.81 processing factors were used for the processed commodities, with the exception of grapes, wheat, and citrus (DP Number : 334173, 08/02 /2007) . T olerance - level residue values for pendimethalin were incorporated for all RACs, current and proposed. The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish over the time period of 2008 : 552 samples - maximum residue = 18 ppb , 2009 : 543 samples

– maximum residue = 13 ppb , and 2010 : 384 samples

– maximum residue = 74 ppb . Over this 3 - year period, PDP analy

zed ~ 1479 samples of catfish for pendimethalin residues. Detects were found in 42 samples of catfish . As a result, these residues in catfish ( fin fish) were included in the dietary risk assessment. The chronic dietary input for catfish was an average (0.035 ppm) of PDPPendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

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### residue data for pendimethalin and the acute dietary input for catfish used the single highest ( 0.074 ppm) value PDP residue data for pendimethalin . Tolerance for crayfish established at 0.05 ppm, (D 332750 and 345270 C. Olinger, 03/31/2008) **I II. Percent Crop Treated Information**  Percent crop treated information was not inco rporated into this assessment. **I V**  **. Drinking Water Data**  The estimated drinking water residues used in the dietary risk assessment were provided b y the Environmental Fate and Effects Division (EFED) in the following memorandum: “ Tier II Estimated Surface Drinking Water Concentrations and Estimated Ground Water Concentration (EDWCs) for Pendimethalin for Use in Human Health Risk Assessment ,” D 334061 , J. B reithaupt 

### , 05/08/2007 , this DWA were to be used as expressed in the referenced email. ( Email : Ibrahim Abdel - Saheb 06/18/2014) and incorporated directly into the dietary

assessment . Water residues were incorporated in the DEEM - FCID into the food categories “water, direct, all s ources” and “water, indirect, all sources.” **Table 5.3 Pendim ethalin EDWCs for the New York Grape Scenario in Surface Water (2007)**  **Drinking Water Source**  **(M odel)**  1 in 10 year annual peak concentration 1 in 10 year annual mean concentration 36 year annual mean concentration **(μg/L) (μg/L)**  **(μg/L)** Surface Water a (PRZM - EXAMS) **77.7 6.0**  4.8 Ground Water SCI - GROW b 0.036 (ug/L)

a From the Tier II PRZM - EXAMS

– (NY grape scenario) b From SCI - GROW model Value s used for risk assessment is **bolded** 

### These 1 

### in 10 year annual peak (acute), 1 

### in 10 year annual mean (non - cancer chronic), and 36 - ye ar annual mean concentrations (cancer chronic) were derived from modeling pendimethalin using the New York grape scenario. Since no degradates have been identified in the metabolism studies at significant (>10 % of applied) levels, no degradates of pendimethalin were modeled in this assessment. The drinking water model s and their description s are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/.Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

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### V. **DEEM -**  **FCID Program and Consumption Information** Pendimethalin acute and chronic dietary e xposure assessment s were conducted using the DEEM FCID, Version 3.16 , which incorporates 2003 - 2008 consumption data from USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 individuals over two non - consecutive survey days. F oods “as con sumed” (e.g., apple pie) are linked to EPA - defined food commodities (e.g. , apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly

by U SDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups . However , for acute exposure assessment , consumption data are retained as individual consumption events. Based on anal ys is of the 2003 - 2008 WWEIA consumption data, which took into account dietary p atterns and survey

r espondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 ye ar old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, adults 20 - 49, females 13 - 49, and adults 50 - 99 ye ars old. For a chronic dietary

e xposure assessment, an estimate of the residue level in each food or food form (e.g., orange or orange juic e) on the food commodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body w eight/day

and as a percent of the cPAD. This procedure is performed for each population subgroup. For an acute exposure assessment, individual one - day f ood consumption data are used on an individual - by- individual basis. The reported consumption amounts of each food item can be multiplied by

a residue point estimate and summed to obtain a total dail y p esticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., onl y those who reported eating relevant commodities/food forms) and a per- capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy , per capita exposure and risk are reported for analyses performed at all levels of refinement . H owever, for deterministic assessments , any significant differences in user vs. per capita exposure and risk are specificall y identified and noted in the risk assessment. **VI . Toxicological**  **Inf**

**ormation** P endimethalin has a low acute toxicity via the oral, dermal, or inhalation route. It is not a dermal or eye irritant ; and is not a dermal sensitizer. The thy roid is a target organ for pendimethalin. Thy roid toxicity

in chronic and subchronic rat and mouse studies was manifested as alterations in thy roid hormones (decreased total T4, and T3, increased percent of free T4 and T3), increased thy roid weight, and microscopic thy roid lesions (including increased thy roid follicular cell height, follicular cell hyp erplasia, as well as follicular cell adenomas).Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

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### Thy roid tumors were observed in both male and female rats in a chronic/carcinogenicity study . There were no tumors observed in the carcinogenicity study in mice. The Health Effects Division (HED) Cancer Peer Review Committee classified pendimethalin (03/18/1992 and re - affirmed 11/01/99) as a "Group C", possible human carcinogen based on a statistically significant increased trend and pair- wise comparison between the high dose group and controls for thy roid follicular cell adenomas in male and female rats. The Committee also recommended a non quantitative approach (i.e., non - linear, RfD approach) since mode of action studies are available that demonstrate that the thy roid tumors are due to a thy roid - pi tuitary

imbalance, and also since pendimethalin was shown to be non - mutagenic in mammalian somatic cells and germ cells. The chronic risk assessment is considered to be protective of any cancer effects; therefore, a separate quantitative cancer aggregate risk assessment is not required. The points of departure and uncertainty factors/safety factors used for dietary risk assessment are summarized in T able 2 . **Table 2.**  **Tox icological Doses and Endpoint for Pendimethalin Human Health Risk Assessment**  **Exposure/Scenario Point of**  **Departure Uncertainty/FQPA** 

**Safety Factors RfD, PAD, Level of Concern** 

**for Risk Assessment Study and Toxicological**  **Effects** Acute Dietary (Females 13 - 49) No appropriate endpoint was identified including developmental toxicity studies in rats and rabbits. Acute Di etary ( General population including infants and children) NOAEL=100 mg/kg UF A = 10 X

UF H = 10 X FQPA SF = 1X Total UF = 10 0X Ac ute RfD = 1

mg/kg/day aPAD = Acute RfD FQPA SF = 1 mg/kg/day Acute neurotoxicity study (MRID 48695601). The LOAEL=300 mg/kg , based on reduced motor activity for males and females on Day 0. Chronic Dietary (all populations) NOAEL = 10 mg/kg/day UF A = 3 X

UF H = 10 X FQPA SF = 1X Total UF = 30X Chronic RfD = 0.3

mg/kg/day cPAD = Chronic RfD FQPA SF = 0. 3 mg/kg/day 92 - Day thyroid function study in rats (MRID 42054601); 56 - day thyroid study in rats (MRID 43135001); 14 - day intra thyroid metabolism study in rats (MRID 43135003). LOAEL = 31 mg/kg/day based on hormonal and histopathological changes in the thyroid. **Cancer** Cancer (oral, dermal, inhalation) Group C, possible human carcinogen based on a statistically significant increased trend and pair - wise comparison between the high dose group and controls for thyroid follicular cell adenomas in male and female rats. A non - quantitative approach (i.e., non - linear, RfD approach) was recommended by the Cancer Peer Review Committee since mode of action studies are available . UF= uncertainty factor, FQ PA SF = FQPA safety factor, NOAEL = no observed adverse effect level, LOAEL = lowest observed adverse effect level, PAD = population adjusted dose (a = acute, c = chronic), RfD = reference dose, MOE = margin of exposure, LOC = level of concern, NA = Not Applicable. UF A= extrapolation from

animal to human (interspecies), UF H = potential variation in sensitivity among members of the human population (intra - species). 

### VII **. Results /Discussion**  As stated above , for the acute and the chronic (food and water) dietary assessments, HED is concerned when dietary risk ex ceeds 100% . The DEEM - FCID anal ys es estimate the dietary exposure and risk of the general U.S. population and selected population subgroups. The chronic results are reported for the general U.S. P opulation, all infants (<1 year old), children 1 - 2,Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

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### children 3 - 5, children 6 - 12, youth 13 - 19, females 13 - 49, adults 20 - 49, females 13

– 49 years and adults 50 - 99 ye ars. The acute results are reported for the females 13 - 49 years old. Acute Dietary

Exposure Assessment The acute dietary

risk estimate for the highest exposed population subgroup, all infants at ( 0.017009 mg/kg/day) is 1.7% of the acute population adjusted dose (aPAD) and for the general U. S. population at ( 0.007311 mg/kg/day) is <1.0 % of the aPAD at the 95 th 

### percentile . HED is concerned when estimated dietary risk exceeds 100%. There are no acute dietary risks of concern . Chronic Dietary

Exposure Assessment The chronic dietary

risk estimate for the highest exposed population subgroup, children 1 - 2 years old at ( 0.005043 mg/kg/day) is 1.7% of the chronic population adjusted dose (cPAD) and for the general U. S. population at ( 0.001592 mg/kg/day) is <1.0 % of the cPAD. HED is concerned when estimated dietary

risk exceeds 100%. There are no chro nic dietary risks of concern . Cancer Dietary

Exposure Assessment Pendimethalin is categorized as “ Group C, possible human carcinogen ." Quantification of risk using a non - linear approach; i.e., RfD /PAD , will adequatel y account for all chronic toxicity, including carcinogenicity, that could result from exposure to pendimethalin . A summary

of the acute and chronic dietary results are reported in Table 3 . **Table 3. Summary of Dietary (Food and Drinking Water)**  **Exposure and Risk for Pendimethalin**

**Population Subgroup Acute Dietary**  **1 (95th Percentile)**  **Chronic Dietary 1**  **Cancer Dietary**  **Exposure (m**  **g/kg/day) %** 

**aPAD*** **Dietary**

**Exposure (m**  **g/kg/day) % cPAD** * **Dietary Exposure**  **(m g/kg/day)**  **Risk** General U.S. Population 0.007311 < 1 0.001592 < 1

Not applicable Not

applicable **All Infants (< 1 year old) 0.017009**  **1.7** 0.003195 1.1 Children 1 - 2 years old 0.015053 1.5 **0.005043 1.7**  Children 3 - 5 years old 0.011605 1. 2 0.003987 1.3 Children 6 - 12 years old 0.007796 < 1 0.002329 < 1 Youth 13 - 19 years old 0.005430 < 1 0.001332 < 1 Adults 20 - 49 years old 0.005967 < 1 0.001256 < 1 Adults 50+ years old 0.005528 < 1 0.001191 < 1 Females 13 - 49 years old 0.006124 < 1 0.001248 < 1 *T he subpopulation (s) wi th the highest risk estimates are **bolded** .Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

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### VIII **. Characterization**  **of Inputs/Outputs** Th ese acute and chronic dietary e xposure and risk anal ys es represent a screening level conservative assessment using tolerance level residues , DEEMTM 7.81 processing factors or empirical processing factors were used when available. Further refinements are not needed at this time since the reported dietary risk result s are not of concern. **IX . Conclusions**  As stated above, for acute and chronic (food and water) dietary assessments, HED is concerned when estimated dietary

risk exceeds 100% of the PAD . These anal ys es demonstrate that the registered use s for pendimethalin will not result in dietary risk s of concern . H ED is confident that the acute and the chronic assessment s do not underestimate exposures and risk s. **X. List of Attachments**  Acute Residue ( F ood and W ater) Input file Acute Results ( F ood and W ater) file Chronic Residue Input file Chronic Results FilePendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

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### Attachment 1 **. Acute Residue Input**  **( F**  **ood and W**  **ater) F**  **ile** US EPA Ver. 3.18, 03 - 08 - d DEEM - FCID Acute analysis for PENDIMETHALIN Residue file name: C: \ Users \ pbarnes \ Documents \ DEEMRESULTS \ Pendimethalin on Hops and Alfalfa dietary files \ PENDIMETHALIN acute hops and alfalfa 7 22 2014.R08 Analysis Date 07 - 22 - 2014 Residue file dated: 07 - 22 - 2014/11:45:26 Reference dose: aRfD = 1 mg/kg bw/day N OEL = 100 mg/kg bw/day Comment: PENDIMETHALIN Hops and Alfalfa

---------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Food Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 1800002000 18 Alfalfa, seed 0.100000 1.000 1.000 1400003000 14 Almond 0.100000 1.000 1.000 1400003001 14 Almond - babyfood 0.100000 1.000 1.000 1400004000 14 Almond, oil 0.100000 1.000 1.000 1400004001 14 Almond, oil - babyfood 0.100000 1.000 1.000 1100 007000 11 Apple, fruit with peel 0.100000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.100000 1.000 1.000 1100008001 11 Apple, peeled fruit - babyfood 0.100000 1.000 1.000 1100009000 11 Apple, dried 0.100000 8.000 1.000 1100009001 11 Apple, dried - babyfood 0.100000 8.000 1.000 1100010000 11 Apple, juice 0.100000 1.300 1.000 1100010001 11 Apple, juice - babyfood 0.100000 1.30 0 1.000 1100011000 11 Apple, sauce 0.100000 1.000 1.000 1100011001 11 Apple, sauce - babyfood 0.100000 1.000 1.000 1202012000 12B Apricot 0.100000 1.000 1.000 1202012001 12B Aprico t - babyfood 0.100000 1.000 1.000 1202013000 12B Apricot, dried 0.100000 6.000 1.000 1202014000 12B Apricot, juice 0.100000 1.000 1.000 1202014001 12B Apricot, juice - babyfood 0.100000 1.000 1.000 9500016000 O Artichoke, globe 0.100000 1.000 1.000PP#6E7

Full comment: PP#6E7129 9500019000 O Asparagus 0.150000 1.000 1.000PP#6E7

Full comment: PP#6E7129 06 03030000 6C Bean, black, seed 0.100000 1.000 1.000 0602031000 6B Bean, broad, succulent 0.100000 1.000 1.000 0603032000 6C Bean, broad, seed 0.100000 1.000 1.000 0602033000 6B Bean, cowpea, suc culent 0.100000 1.000 1.000 0603034000 6C Bean, cowpea, seed 0.100000 1.000 1.000 0603035000 6C Bean, great northern, seed 0.100000 1.000 1.000 0603036000 6C Bean, kidney, seed 0.100000 1.000 1.000 0602037000 6B Bean, lima, succulent 0.100000 1.000 1.000 0603038000 6C Bean, lima, seed 0.100000 1.000 1.000 0603039000 6C Bean, mung, seed 0.100000 1.000 1.000 0603040000 6C Be an, navy, seed 0.100000 1.000 1.000 0603041000 6C Bean, pink, seed 0.100000 1.000 1.000 0603042000 6C Bean, pinto, seed 0.100000 1.000 1.000 0601043000 6A Bean, snap, succulent 0.100000 1.000 1.000 0601043001 6A Bean, snap, succulent - babyfood 0.100000 1.000 1.000 1302057000 13B Blueberry 0.100000 1.000 1.000 1302057001 13B Blueberry - babyfood 0.100000 1.000 1.000 14000 59000 14 Brazil nut 0.100000 1.000 1.000 0501061000 5A Broccoli 0.100000 1.000 1.000PP#6E7

Full comment: PP#6E7129 0501061001 5A Broccoli - babyfood 0.100000 1.000 1. 000PP#6E7

Full comment: PP#6E7129 0501062000 5A Broccoli, Chinese 0.100000 1.000 1.000PP#6E7

Full comment: PP#6E7129 0502063000 5B Broccoli raab 0.200000 1.000 1.000 0501064000 5A Brusse ls sprouts 0.100000 1.000 1.000PP#6E7

Full comment: PP#6E7129 1400068000 14 Butternut 0.100000 1.000 1.000 0501069000 5A Cabbage 0.100000 1.000 1.000PP#6E7

Full comment: PP#6E7129 0502070000 5B Cabbage, Chinese, bok choy 0.200000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 0.100000 1.000 1.000PP#6E7

Full comment: PP#6E7129 0501072000 5A Cabbage, Chinese, musta rd 0.100000 1.000 1.000PP#6E7Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

Page 10 of 19 Full comment: PP#6E7129 0901075000 9A Cantaloupe 0.100000 1.000 1.000 0101078000 1AB Carrot 0.500000 1.000 1.000 0101078001 1AB Carrot - babyfood 0.500000 1.000 1.000 0101079000 1AB Carrot, juice 0.500000 1.000 1.000 1400081000 14 Cashew 0.100000 1.000 1.000 0501083000 5A Cauliflower 0.100000 1.000 1.000PP#6E7

Full comment: PP#6E7129 1201090000 12A Cherry 0.100000 1.000 1.000 1201090001 12A Cherry - babyfood 0.100000 1.000 1.000 1201091000 12A Cherry, juice 0.100000 1.500 1.000 1201091001 12A Cherry, juice - babyfood 0.100000 1.500 1.000 1400092000 14 Chestnut 0.100000 1.000 1.000 0603098000 6C Chickpea, seed 0.100000 1.000 1.000 0603098001 6C Chickpea, seed - babyfood 0.100000 1.000 1.000 0603099000 6C Chickpea, flour 0.100000 1.000 1.000 0302103000 3B Chive, fresh leaves 0.100000 1.000 1.000 1001106000 10A Citron 0.100000 1.000 1.000 1001107000 10A Citrus hybrids 0.100000 1.000 1.000 1001108000 10A Citrus, oil 0.500000 1.000 1.000 0502117000 5B Collards 0.200 000 1.000 1.000 1500120000 15 Corn, field, flour 0.100000 1.000 1.000 1500120001 15 Corn, field, flour - babyfood 0.100000 1.000 1.000 1500121000 15 Corn, field, meal 0.100000 1.000 1.000 1500121001 1 5 Corn, field, meal - babyfood 0.100000 1.000 1.000 1500122000 15 Corn, field, bran 0.100000 1.000 1.000 1500123000 15 Corn, field, starch 0.100000 1.000 1.000 1500123001 15 Corn, field, starch - babyfoo d 0.100000 1.000 1.000 1500124000 15 Corn, field, syrup 0.100000 1.500 1.000 1500124001 15 Corn, field, syrup - babyfood 0.100000 1.500 1.000 1500125000 15 Corn, field, oil 0.100000 1.000 1.000 1500125001 15 Corn, field, oil - babyfood 0.100000 1.000 1.000 1500127000 15 Corn, sweet 0.100000 1.000 1.000 1500127001 15 Corn, sweet - babyfood 0.100000 1.000 1.000 2003128000 20C Cottonseed, oi l 0.100000 1.000 1.000 2003128001 20C Cottonseed, oil - babyfood 0.100000 1.000 1.000 1100129000 11 Crabapple 0.100000 1.000 1.000 1307130000 13G Cranberry 0.100000 1.000 1.000 1307130001 13G Cranberry - babyfood 0.100000 1.000 1.000 1307131000 13G Cranberry, dried 0.100000 1.000 1.000 1307132000 13G Cranberry, juice 0.100000 1.000 1.000 1307132001 13G C ranberry, juice - babyfood 0.100000 1.000 1.000 0802148000 8BC Eggplant 0.100000 1.000 1.000 1400155000 14 Hazelnut 0.100000 1.000 1.000 1400156000 14 Hazelnut, oil 0.100000 1.000 1.000 8000157000 80 Fish - freshwater finfish 0.074000 1.000 1.000 8000158000 80 Fish - freshwater finfish, farm ra 0.074000 1.000 1.000 8000159000 80 Fish - saltwater finfish, tuna 0.074000 1.000 1.000 8000160000 80 Fish - saltwater finfish, other 0.074000 1.000 1.000 8000161000 80 Fish - shellfish, crustacean 0.050000 1.000 1.000 0301165000 3A Garlic, bulb 0.100000 1.000 1.000 0301165001 3A Garlic, bulb - ba byfood 0.100000 1.000 1.000 1302174000 13B Gooseberry 0.100000 1.000 1.000 1304175000 13D Grape 0.100000 1.000 1.000PP#6E7

Full comment: PP#6E7129 1304176000 13D Grape, juice 0.100000 1.000 1.000change

Full comment: changed to 0.1 as per D343402 1304176001 13D Grape, juice - babyfood 0.100000 1.000 1.000PP#6E7

Full comment: PP#6E7129 9500177000 O Grape, leaves 0.100000 1.000 1.000PP#6E7

Full comment: PP#6E7129 9500178000 O Grape, raisin 0.100000 1.000 1.000PP#6E7

Full comment: PP#6E7129 1304179000 13D Grape, wine and sherry 0.100000 1.000 1.000PP#6E7

Full comment: PP#6E7129 1003180000 10C Grapefruit 0.100000 1.000 1.000 1003181000 10C Grapefruit, juice 0.100000 1.000 1.000 0603182000 6C Guar, seed 0.100000 1.000 1.000 0603182001 6C Guar, seed - babyfood 0.100000 1.000 1.000 1400185000 14 Hickory nut 0.100000 1.000 1.000 0901187000 9A Honeydew melon 0.100000 1.000 1. 000Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

Page 11 of 19 9500188000 O Hop 0.100000 1.000 1.000 0502194000 5B Kale 0.200000 1.000 1.000 1304195000 13D Kiwifruit, fuzzy 0.100000 1.000 1.000 0501196000 5A Kohlrabi 0.100000 1.000 1.000PP#6E7

Full comment: PP#6E7129 1002197000 10B Kumquat 0.100000 1.000 1.000 0302198000 3B Leek 0.200000 1.000 1.000 1002199000 10B Le mon 0.100000 1.000 1.000 1002200000 10B Lemon, juice 0.100000 1.000 1.000 1002200001 10B Lemon, juice - babyfood 0.100000 1.000 1.000 1002201000 10B Lemon, peel 0.100000 1.000 1.000 0603203000 6C Lentil, seed 0.100000 1.000 1.000 0401205000 4A Lettuce, leaf 4.000000 1.000 1.000 1002206000 10B Lime 0.100000 1.000 1.000 10022 07000 10B Lime, juice 0.100000 1.000 1.000 1002207001 10B Lime, juice - babyfood 0.100000 1.000 1.000 1100210000 11 Loquat 0.100000 1.000 1.000 1400213000 14 Macadamia nut 0.100000 1.000 1.000 0502229000 5B Mustard greens 0.200000 1.000 1.000 1202230000 12B Nectarine 0.100000 1.000 1.000 0802234000 8BC Okra 0.100000 1.000 1.000 9500235000 O Olive 0.100000 1.000 1.000 9500236000 O Olive, oil 0.100000 1.000 1.000 0301237000 3A Onion, bulb 0.100000 1.000 1.000 0301237001 3A Onion, bulb - babyfood 0.100000 1.000 1.000 0301238000 3A Onion, bulb, dried 0.100000 9.000 1.000 0301238001 3A Onion, bulb, dried - babyfood 0.100000 9.000 1.000 0302239000 3B Onion, green 0.2 00000 1.000 1.000 1001240000 10A Orange 0.100000 1.000 1.000 1001241000 10A Orange, juice 0.100000 1.000 1.000 1001241001 10A Orange, juice - babyfood 0.100000 1.000 1.000 1001242000 10A Orange, peel 0.100000 1.000 1.000 0602255000 6B Pea, succulent 0.100000 1.000 1.000 0602255001 6B Pea, succulent - babyfood 0.100000 1.000 1.000 0603256000 6C Pea, dry 0.100000 1.000 1.000 0603256001 6C Pea, dry - babyfood 0.100000 1.000 1.000 0601257000 6A Pea, edible podded, succulent 0.100000 1.000 1.000 0603258000 6C Pea, pigeon, seed 0.100000 1.000 1.0 00 0602259000 6B Pea, pigeon, succulent 0.100000 1.000 1.000 1202260000 12B Peach 0.100000 1.000 1.000 1202260001 12B Peach - babyfood 0.100000 1.000 1.000 1202261000 12B Peach, dried 0.100000 7.000 1.000 1202261001 12B Peach, dried - babyfood 0.100000 7.000 1.000 1202262000 12B Peach, juice 0.100000 1.000 1.000 1202262001 12B Peach, juice - babyfood 0.100000 1.000 1.000 9500263000 O Peanut 0.100000 1.000 1.000 9500264000 O Peanut, butter 0.100000 1.890 1.000 9500265000 O Peanut, oil 0.100000 1.000 1.000 1100266000 11 Pear 0.100000 1.000 1.000 1100266001 11 Pear - babyfood 0.100000 1.000 1.000 1100267000 11 Pear, dried 0.100000 6.250 1.000 1100268000 11 Pear, juice 0.100000 1.000 1.000 1100268001 11 Pear, juice - babyfood 0.100000 1.000 1.000 1400269000 14 Pecan 0.100000 1.000 1.000 0802270000 8B Pepper, bell 0.100000 1.000 1.000 08 02270001 8B Pepper, bell - babyfood 0.100000 1.000 1.000 0802271000 8B Pepper, bell, dried 0.100000 1.000 1.000 0802271001 8B Pepper, bell, dried - babyfood 0.100000 1.000 1.000 0802272000 8BC Pepper, nonbell 0.100000 1.000 1.000 0802272001 8BC Pepper, nonbell - babyfood 0.100000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 0.100000 1.000 1.000 9500275000 O Peppermint 0.200000 1.000 1.000 9500276000 O Peppermint, oil 1.000000 1.000 1.000 1400278000 14 Pine nut 0.100000 1.000 1.000 1400282000 14 Pistachio 0.100000 1.000 1.000 1203285000 12C Pl um 0.100000 1.000 1.000 1203285001 12C Plum - babyfood 0.100000 1.000 1.000 1203286000 12C Plum, prune, fresh 0.100000 1.000 1.000 1203286001 12C Plum, prune, fresh - babyfood 0.100000 1.000 1.000 1203287000 12C Plum, prune, dried 0.100000 5.000 1.000 1203287001 12C Plum, prune, dried - babyfood 0.100000 5.000 1.000Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

Page 12 of 19 1203288000 12C Plum, prune, juice 0.100000 1.400 1.000 12032 88001 12C Plum, prune, juice - babyfood 0.100000 1.400 1.000 9500289000 O Pomegranate 0.100000 1.000 1.000 0103296000 1C Potato, chips 0.100000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.100000 6.500 1.000 0103297001 1C Potato, dry (granules/ flakes) - b 0.100000 6.500 1.000 0103298000 1C Potato, flour 0.100000 6.500 1.000 0103298001 1C Potato, flour - babyfood 0.100000 6.500 1.000 0103299000 1C Potato, tuber, w/peel 0.100000 1.000 1.000 0103299001 1C Potato, tuber, w/peel - babyfood 0.100000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.100000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel - babyfood 0.100000 1.000 1.000 1003307000 10C Pummelo 0.100000 1.000 1.000 1100310000 11 Quince 0.100000 1.000 1.000 0502318000 5B Rape greens 0.200000 1.000 1.000 1500323000 15 Rice, white 0.100000 1.000 1.000 1500323001 15 Rice, white - babyfood 0.100000 1.000 1.000 1500324000 15 Rice, brown 0.100000 1.000 1.000 15 00324001 15 Rice, brown - babyfood 0.100000 1.000 1.000 1500325000 15 Rice, flour 0.100000 1.000 1.000 1500325001 15 Rice, flour - babyfood 0.100000 1.000 1.000 1500326000 15 Rice, bran 0.100000 1.000 1.000 1500326001 15 Rice, bran - babyfood 0.100000 1.000 1.000 2002330000 20B Safflower, oil 0.100000 1.000 1.000 2002330001 20B Safflower, oil - babyfood 0.100000 1. 000 1.000 0302338500 3B Shallot, fresh leaves 0.200000 1.000 1.000 1500344000 15 Sorghum, grain 0.100000 1.000 1.000 0600347000 6 Soybean, seed 0.100000 1.000 1.000 0603348000 6C Soyb ean, flour 0.100000 1.000 1.000 0603348001 6C Soybean, flour - babyfood 0.100000 1.000 1.000 0600349000 6 Soybean, soy milk 0.100000 1.000 1.000 0600349001 6 Soybean, soy milk - babyfood or in 0.100000 1.000 1.000 0600350000 6 Soybean, oil 0.100000 1.000 1.000 0600350001 6 Soybean, oil - babyfood 0.100000 1.000 1.000 9500352000 O Spearmint 0.200000 1.000 1.000 9500353000 O Spearmint, oil 1.000000 1.000 1.000 1307359000 13G Strawberry 0.100000 1.000 1.000 1307359001 13G Strawberry - babyfood 0.100000 1.000 1.000 1307360000 13G Strawberry, jui ce 0.100000 1.000 1.000 1307360001 13G Strawberry, juice - babyfood 0.100000 1.000 1.000 9500362000 O Sugarcane, sugar 0.100000 1.000 1.000 9500362001 O Sugarcane, sugar - babyfood 0.100000 1.000 1.000 9500363000 O Sugarcane, molasses 0.100000 1.000 1.000 9500363001 O Sugarcane, molasses - babyfood 0.100000 1.000 1.000 2002364000 20B Sunflower, seed 0.100000 1.000 1.000 2002365000 20B Su nflower, oil 0.100000 1.000 1.000 2002365001 20B Sunflower, oil - babyfood 0.100000 1.000 1.000 1001369000 10A Tangerine 0.100000 1.000 1.000 1001370000 10A Tangerine, juice 0.100000 1.000 1.000 0801374000 8A Tomatillo 0.100000 1.000 1.000 0801375000 8A Tomato 0.100000 1.000 1.000 0801375001 8A Tomato - babyfood 0.100000 1.000 1.000 08013 76000 8A Tomato, paste 0.100000 5.400 1.000 0801376001 8A Tomato, paste - babyfood 0.100000 5.400 1.000 0801377000 8A Tomato, puree 0.100000 3.300 1.000 0801377001 8A Tomato, puree - babyfo od 0.100000 3.300 1.000 0801378000 8A Tomato, dried 0.100000 14.300 1.000 0801378001 8A Tomato, dried - babyfood 0.100000 14.300 1.000 0801379000 8A Tomato, juice 0.100000 1.500 1.000 0801380000 8A Tomato, Tree 0.100000 1.000 1.000 0502389000 5B Turnip, greens 0.200000 1.000 1.000 1400391000 14 Walnut 0.100000 1.000 1.000 8601000000 86A Water, direct, all sources 0.077700 1.000 1.000 8602000000 86B Water, indirect, all sources 0.077700 1.000 1.000 0901399000 9A Watermelon 0.100000 1.000 1.000 0901400000 9A Watermelon, juice 0.1 00000 1.000 1.000 1500401000 15 Wheat, grain 0.100000 1.000 1.000 1500401001 15 Wheat, grain - babyfood 0.100000 1.000 1.000 1500402000 15 Wheat, flour 0.100000 1.400 1.000 1500402001 15 Wheat, flour - babyfood 0.100000 1.400 1.000 1500403000 15 Wheat, germ 0.100000 8.000 1.000Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

Page 13 of 19 1500404000 15 Wheat, bran 0.100000 8.000 1.000 1500405000 15 Wild rice 0.100000 1.000 1.000 0301338000 3A Shallot, bulb 0.100000 1.000 1.000 1901102500 19A Chive, dried leaves 0.100000 1.000 1.000 

### Attachment 2. Acute Results (F ood and W ater) File

US EPA Ver. 3.18, 03 - 08 - d DEEM - FCID ACUTE Analysis for PENDIMETHALIN NHANES 2003 - 2008 2 - Day Residue file: PENDIMETHALIN acute hops and alfalfa 7 22 2014.R08 Adjustment factor #2 used. Analysis Da te: 07 - 22 - 2014/11:47:09 Residue file dated: 07 - 22 - 2014/11:45:26 NOEL (Acute) = 100.000000 mg/kg body - wt/day RAC/FF intake summed over 24 hours Run Comment: "PENDIMETHALIN Hops and Alfalfa"

================================================================ =============== Summary calculations -- per capita:

--- 95th Percentile ---- --- 99th Percentile ---- --- 99.9th Percentile ---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Total US Population: 0.007311 0.73 13678 0.011583 1.16 8633 0.018799 1.88 5319 All Infants: 0.017009 1.70 5879 0.023060 2.31 4336 0.027729 2.77 3606 Female 13 - 50: 0.006106 0.61 16376 0.008599 0.86 11629 0.012530 1.25 7981 Children 1 - 2: 0.015053 1.51 6643 0.019900 1.99 5025 0.033249 3.32 3007 Children 3 - 5: 0.011605 1.16 8616 0.016573 1.66 6033 0.020131 2.01 4967 Children 6 - 12: 0.007796 0.78 12826 0.011329 1.13 8826 0.015618 1.56 6402 Youth 13 - 19: 0.005430 0.5 4 18416 0.008251 0.83 12120 0.010560 1.06 9469 Adults 20 - 49: 0.005967 0.60 16758 0.008613 0.86 11610 0.012261 1.23 8156 Adults 50 - 99: 0.005528 0.55 18089 0.007899 0.79 12660 0.012146 1.21 8233 Female 13 - 49: 0.006124 0.61 16330 0.008575 0.86 11661 0.012516 1.25 7989Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

Page 14 of 19 

### Attachment **3 .**  **Chronic Residue Input F**  **ile** US EPA Ver. 3.16, 03 - 08 - d DEEM - FCID Chronic analysis for PENDIMETHALIN Residue file: C: \ Users \ pbarnes \ Documents \ DEEMRESULTS \ Pendimethalin on Hops and Alfalfa dietary files \ PENDIMETHALIN chronic hops and alfalfa 7 22 2014.R08 Adjust. #2 used Analysis Date 07 - 22 - 2014 Residue file dated: 07 - 22 - 2014/11:49:32 Reference dose (RfD) = 0.3 mg/kg bw/day Comment:PENDIMETHALIN Hops and Alfalfa

---------------------------------------------------------------------------- ------ Food Crop Residue Adj.Factors EPA Code Grp Food Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ 1800002000 18 Alfalfa, seed 0.100000 1.000 1.000 1400003000 14 Almond 0.100000 1.000 1.000 1400003001 14 Almond - babyfood 0.100000 1.000 1.000 1400004000 14 Almond, oil 0.100000 1.000 1.000 1400004001 14 Almond, oil - babyfood 0.100000 1.000 1.000 1100007000 11 Apple, fruit with peel 0.100000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.100000 1.000 1.000 1100008001 11 Apple, peeled fruit - babyfood 0.100000 1.000 1.000 1100009000 11 Apple, dried 0.100000 8.000 1.000 1100009001 11 Appl e, dried - babyfood 0.100000 8.000 1.000 1100010000 11 Apple, juice 0.100000 1.300 1.000 1100010001 11 Apple, juice - babyfood 0.100000 1.300 1.000 1100011000 11 Apple, sauce 0.100000 1.000 1.000 1100011001 11 Apple, sauce - babyfood 0.100000 1.000 1.000 1202012000 12B Apricot 0.100000 1.000 1.000 1202012001 12B Apricot - babyfood 0.100000 1.000 1.000 1202013000 12B Apricot, dried 0.100000 6.000 1.000 1202014000 12B Apricot, juice 0.100000 1.000 1.000 1202014001 12B Apricot, juice - babyfood 0.100000 1.000 1.000 9500016000 O Artichoke, globe 0.100000 1.000 1.000 9500019000 O Asparagus 0.150000 1.000 1.000 0603030000 6C Bean, black, seed 0.100000 1.000 1.000 0602031000 6B Bean, broad, succulent 0.100000 1.000 1.000 0603032000 6C Bean, broad, seed 0.100000 1.000 1.000 0602033000 6B Bean, cowpea, succulent 0.100000 1.000 1.000 0603034000 6C Bean, cowpea, seed 0.100000 1.000 1.000 0603035000 6C Bean, great northern, seed 0.100000 1.000 1.000 0603036000 6C Bean, kidney, seed 0.100000 1.000 1.000 0602037000 6B Bean, lima, succulent 0.100000 1.000 1.000 0603038000 6C Bean, lima, seed 0.100000 1.000 1.000 0603039000 6C Bean, mung, seed 0.100000 1.000 1.000 0603040000 6C Bean, navy, seed 0.100000 1.000 1.000 0603041000 6C Bean, pink, seed 0.100000 1.000 1.000 0603042000 6C Bean, pinto, seed 0.100000 1.000 1.000 0601043000 6A Bean, snap, succulent 0.100000 1.000 1.000 0601043001 6A Bean, snap, succulent - babyfood 0.100000 1.000 1.000 1302057000 13B Blueberry 0.100000 1.000 1.000 1302057001 13B Blueberry - babyfood 0.100000 1.000 1.000 1400059000 14 Brazil nut 0.100000 1.000 1.000 0501061000 5A Broccoli 0.100000 1.000 1.000 0501061001 5A Broc coli - babyfood 0.100000 1.000 1.000 0501062000 5A Broccoli, Chinese 0.100000 1.000 1.000 0502063000 5B Broccoli raab 0.200000 1.000 1.000 0501064000 5A Brussels sprou ts 0.100000 1.000 1.000 1400068000 14 Butternut 0.100000 1.000 1.000 0501069000 5A Cabbage 0.100000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok ch oy 0.200000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 0.100000 1.000 1.000Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

Page 15 of 19 0501072000 5A Cabbage, Chinese, mustard 0.100000 1.000 1.000 0901075000 9A Cantaloupe 0.100000 1.000 1.000 0101078000 1AB Carrot 0.500000 1.000 1.000 0101078001 1AB Carrot - babyfood 0.500000 1.000 1.000 0101079000 1AB Carrot, juice 0.500000 1.000 1.000 1400081000 14 Cashew 0.100000 1.000 1.000 0501083000 5A Cauliflower 0.100000 1.000 1.000 1201090000 12A Cherry 0.100000 1.000 1.000 1201090001 12A Cherry - babyfood 0.100000 1.000 1.000 1201091000 12A Cherry, juice 0.100000 1.500 1.000 1201091001 12A Cherry, juice - babyfood 0.100000 1.500 1.000 1400092000 14 Chestnut 0.100000 1.000 1.000 0603098000 6C Chickpea, seed 0.100000 1.000 1.000 0603098001 6C Chickpea, seed - babyfood 0.100000 1.000 1.000 0603099000 6C Chickpea, flour 0.100000 1.000 1.000 0302103000 3B Chive, fresh leaves 0.100000 1.000 1.000 1001106000 10A Citr on 0.100000 1.000 1.000 1001107000 10A Citrus hybrids 0.100000 1.000 1.000 1001108000 10A Citrus, oil 0.500000 1.000 1.000 0502117000 5B Collards 0.200000 1.000 1.000 1500120000 15 Corn, field, flour 0.100000 1.000 1.000 1500120001 15 Corn, field, flour - babyfood 0.100000 1.000 1.000 1500121000 15 Corn, field, meal 0.100000 1.000 1.000 1500121001 15 Corn, field, meal - babyfood 0.100000 1.000 1.000 1500122000 15 Corn, field, bran 0.100000 1.000 1.000 1500123000 15 Corn, field, starch 0.100000 1.000 1.000 1500123001 15 Corn, field, starch - babyfood 0.100000 1.000 1.000 1500124000 15 Corn, field, syrup 0.100000 1.500 1.000 1500124001 15 Corn, field, syrup - babyfood 0.100000 1.500 1.000 1500125000 15 Corn, field, oil 0.100000 1.000 1.000 1500125001 15 Corn, field, oil - babyfood 0.100000 1.000 1.000 1500127000 15 Corn, sweet 0.100000 1.000 1.000 1500127001 15 Corn, sweet - babyfood 0.100000 1.000 1.000 2003128000 20C Cottonseed, oil 0.100000 1.000 1.000 2003128001 20C Cott onseed, oil - babyfood 0.100000 1.000 1.000 1100129000 11 Crabapple 0.100000 1.000 1.000 1307130000 13G Cranberry 0.100000 1.000 1.000 1307130001 13G Cranberry - babyfood 0.100000 1.000 1.000 1307131000 13G Cranberry, dried 0.100000 1.000 1.000 1307132000 13G Cranberry, juice 0.100000 1.000 1.000 1307132001 13G Cranberry, juice - babyfood 0.100000 1.000 1.000 0802148000 8BC Eggplant 0.100000 1.000 1.000 1400155000 14 Hazelnut 0.100000 1.000 1.000 1400156000 14 Haze lnut, oil 0.100000 1.000 1.000 8000157000 80 Fish - freshwater finfish 0.035000 1.000 1.000 8000158000 80 Fish - freshwater finfish, farm ra 0.035000 1.000 1.000 8000159000 80 Fish - saltwater finfish, tuna 0.035000 1.000 1.000 8000160000 80 Fish - saltwater finfish, other 0.035000 1.000 1.000 8000161000 80 Fish - shellfish, crustacean 0.050000 1.000 1.000 0301165000 3A Garlic, bulb 0.100000 1.000 1.000 0301165001 3A Garlic, bulb - babyfood 0.100000 1.000 1.000 1302174000 13B Gooseberry 0.100000 1.000 1.000 1304175000 13D Grape 0.100000 1.000 1.000 1304176000 13D Grape, juice 0.100000 1.000 1.000 1304176001 13D Grape, juice - babyfood 0.100000 1.000 1.000 9500177000 O Grape, leaves 0.100000 1.000 1.000 9500178000 O Grape, raisin 0.100000 1.000 1.000 1304179000 13D Grape, wine and sherry 0.100000 1.000 1.000 1003180000 10C Grapefruit 0.100000 1.000 1.000 1003181000 10C Grapefruit, juice 0.100000 1.000 1.000 0603182000 6C Guar, seed 0.100000 1.000 1.000 0603182001 6C Guar, seed - babyfood 0.100000 1.000 1.000 1400185000 14 Hickory nut 0.100000 1.000 1.000Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

Page 16 of 19 0901187000 9A Honeydew melon 0.100000 1.000 1.000 9500188000 O Hop 0.100000 1.000 1.000 0502194000 5B Kale 0.200000 1.000 1.000 1304195000 13D Kiwifruit, fuzzy 0.100000 1.000 1.000 0501196000 5A Kohlrabi 0.100000 1.000 1.000 1002197000 10B Kumquat 0.100000 1.000 1.000 0302198000 3B Leek 0.200000 1.000 1.000 1002199000 10B Lemon 0.100000 1.000 1.000 1002200000 10B Lemon, juice 0.100000 1.000 1.000 1002200001 10B Lemon, juice - babyfood 0.100000 1.000 1.000 1002201000 10B Lemon, peel 0.100000 1.000 1.000 0603203000 6C Lentil, seed 0.100000 1.000 1.000 0401205000 4A Lettuce, leaf 4.000000 1.000 1.000 1002206000 10B Lime 0.100000 1.000 1.000 1002207000 10B Lime , juice 0.100000 1.000 1.000 1002207001 10B Lime, juice - babyfood 0.100000 1.000 1.000 1100210000 11 Loquat 0.100000 1.000 1.000 1400213000 14 Macadamia nut 0.100000 1.000 1.000 0502229000 5B Mustard greens 0.200000 1.000 1.000 1202230000 12B Nectarine 0.100000 1.000 1.000 0802234000 8BC Okra 0.100000 1.000 1.000 9500235000 O Olive 0.100000 1.000 1.000 9500236000 O Olive, oil 0.100000 1.000 1.000 0301237000 3A Onion, bulb 0.100000 1.000 1.000 0301237001 3A Onion, bulb - babyfood 0.100000 1.000 1.000 0301238000 3A Onion, bulb, dried 0.100000 9.000 1.000 0301238001 3A Onion, bulb, dried - babyfood 0.100000 9.000 1.000 0302239000 3B Onion, green 0.200000 1.000 1.000 1001240000 10A Orange 0.100000 1.000 1.000 1001241000 10A Orange, juice 0.100000 1.000 1.000 1001241001 10A Orange, juice - babyfood 0.100000 1.000 1.000 1001242000 10A Orange, peel 0.100000 1.000 1.000 0602255000 6B Pea, succulent 0.100000 1.000 1.000 0602255001 6B Pea, succulent - babyfood 0.100000 1.000 1.000 0603256000 6C Pea, dry 0.100000 1.000 1.000 0603256001 6C Pea, dry - babyfood 0.100000 1.000 1.000 0601257000 6A Pea, edible podded, succulent 0.100000 1.000 1.000 0603258000 6C Pea, pigeon, seed 0.100000 1.000 1.000 0602259000 6B Pea, pigeon, succulent 0.100000 1.000 1.000 1202260000 12B Peach 0.100000 1.000 1.000 1202260001 12B Peach - babyfood 0.100000 1.000 1.000 1202261000 12B Peach, dried 0.100000 7.000 1.000 1202261001 12B Peach, dried - babyfood 0.100000 7.000 1.000 1202262000 12B Peach, juice 0.100000 1.000 1.000 1202262001 12B Peach, juice - babyfood 0.100000 1.000 1.000 9500263000 O Peanut 0.100000 1.000 1.000 9500264000 O Peanut, butter 0.100000 1.890 1.000 9500265000 O Peanut, oil 0.100000 1.000 1.000 1100266000 11 Pear 0.100000 1.000 1.000 1100266001 11 Pear - babyfood 0.100000 1.000 1.000 1100267000 11 Pear, dried 0.100000 6.250 1.000 1100268000 11 Pear, juice 0.100000 1.000 1.000 1100268001 11 Pear, juice - babyfood 0.100000 1.000 1.000 1400269000 14 Pecan 0.100000 1.000 1.000 0802270000 8B Pepper, bell 0.100000 1.000 1.000 0802270001 8B Pepper, bell - babyfood 0.100000 1.000 1.000 0802271000 8B Pepper, bell, dried 0.100000 1.000 1.000 0802271001 8B Pepper, bell, dried - babyfood 0.100000 1.000 1.000 0802272000 8BC Pepper, nonbell 0.100000 1.000 1.000 0802272001 8BC Pepper, nonbell - babyfood 0.100000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 0.100000 1.000 1.000 9500275000 O Peppermint 0.200000 1.000 1.000 9500276000 O Peppermint, oil 1.000000 1.000 1.000Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

Page 17 of 19 1400278000 14 Pine nut 0.100000 1.000 1.000 1400282000 14 Pistachio 0.100000 1.000 1.000 1203285000 12C Plum 0.100000 1.000 1.000 1203285001 12C Plum - babyfood 0.100000 1.000 1.000 1203286000 12C Plum, prune, fresh 0.100000 1.000 1.000 1203286001 12C Plum, prune, f resh - babyfood 0.100000 1.000 1.000 1203287000 12C Plum, prune, dried 0.100000 5.000 1.000 1203287001 12C Plum, prune, dried - babyfood 0.100000 5.000 1.000 1203288000 12C Plum, prune, juice 0.100000 1.400 1.000 1203288001 12C Plum, prune, juice - babyfood 0.100000 1.400 1.000 9500289000 O Pomegranate 0.100000 1.000 1.000 0103296000 1C Potato, chips 0.100000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.100000 6.500 1.000 0103297001 1C Potato, dry (granules/ flakes) - b 0.100000 6.500 1.000 0103298000 1C Potato, flour 0.100000 6.500 1.000 0103298001 1C Potato, flour - babyfood 0.100000 6.500 1.000 0103299000 1C Potato, tuber, w/peel 0.100000 1.000 1.000 0103299001 1C Potato, tuber, w/peel - babyfood 0.100000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.100000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel - babyfood 0.100000 1.000 1.000 1003307000 10C Pummelo 0.100000 1.000 1.000 1100310000 11 Quince 0.100000 1.000 1.000 0502318000 5B Rape greens 0.200000 1.000 1.000 1500323000 15 Rice, white 0.100000 1.000 1.000 1500323001 15 Rice, white - babyfood 0.100000 1.000 1.000 1500324000 15 Rice, brown 0.100000 1.000 1.000 1500324001 15 Rice, brown - babyfood 0.100000 1.000 1.000 1500325000 15 Rice, flour 0.100000 1.000 1.000 1500325001 15 Rice, flour - babyfood 0.100000 1.000 1.000 1500326000 15 Rice, bran 0.100000 1.000 1.000 1500326001 15 Rice , bran - babyfood 0.100000 1.000 1.000 2002330000 20B Safflower, oil 0.100000 1.000 1.000 2002330001 20B Safflower, oil - babyfood 0.100000 1.000 1.000 0302338500 3B Shallot, fresh leaves 0.200000 1.000 1.000 1500344000 15 Sorghum, grain 0.100000 1.000 1.000 0600347000 6 Soybean, seed 0.100000 1.000 1.000 0603348000 6C Soybean, flour 0.100000 1.000 1.000 0603348001 6C Soybean, flour - babyfood 0.100000 1.000 1.000 0600349000 6 Soybean, soy milk 0.100000 1.000 1.000 0600349001 6 Soyb ean, soy milk - babyfood or in 0.100000 1.000 1.000 0600350000 6 Soybean, oil 0.100000 1.000 1.000 0600350001 6 Soybean, oil - babyfood 0.100000 1.000 1.000 9500352000 O Spearmint 0.200000 1.000 1.000 9500353000 O Spearmint, oil 1.000000 1.000 1.000 1307359000 13G Strawberry 0.100000 1.000 1.000 1307359001 13G Strawberry - babyfood 0.100000 1.000 1.000 1307360000 13G Strawberry, juice 0.100000 1.000 1.000 1307360001 13G Strawberry, juice - babyfood 0.100000 1.000 1.000 9500362000 O Sugarcane, sugar 0.100000 1.000 1.000 9500362001 O Sugarcane, sugar - babyfood 0.100000 1.000 1.000 9500363000 O Sugarcane, molasses 0.100000 1.000 1.000 9500363001 O Sugarcane, molasses - babyfood 0.100000 1.000 1.000 2002364000 20B Sunflower, seed 0.100000 1.000 1.000 2002365000 20B Sunflower, oil 0.100000 1.000 1.000 2002365001 20B Sunflower, oil - babyfood 0.100000 1.000 1.000 1001369000 10A Tangerine 0.100000 1.000 1.000 1001370000 10A Tangerine, juice 0.100000 1.000 1.000 0801374000 8A Toma tillo 0.100000 1.000 1.000 0801375000 8A Tomato 0.100000 1.000 1.000 0801375001 8A Tomato - babyfood 0.100000 1.000 1.000 0801376000 8A Tomato, paste 0.100000 5.400 1.000 0801376001 8A Tomato, paste - babyfood 0.100000 5.400 1.000 0801377000 8A Tomato, puree 0.100000 3.300 1.000Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

Page 18 of 19 0801377001 8A Tomato, puree - babyfood 0.100000 3.300 1.000 0801378000 8A Tomato, dried 0.100000 14.300 1.000 0801378001 8A Tomato, dried - babyfood 0.100000 14.300 1.000 0801379000 8A Tomato, juice 0.100000 1.500 1.000 0801380000 8A Tomato, Tree 0.100000 1.000 1.000 0502389000 5B Turnip, greens 0.200000 1.000 1.000 1400391000 14 Walnut 0.100000 1.000 1.000 8601000000 86A Water, direct, all sources 0.006000 1.000 1.000 8602000000 86B Water, indirect, all sources 0.006000 1.000 1.000 0901399000 9A Watermelon 0.100000 1.000 1.000 0901400000 9A Watermelon, juice 0.100000 1.000 1.000 1500401000 15 Wheat, grain 0.100000 1.000 1.000 1500401001 15 Wheat, grain - babyfood 0.100000 1.000 1.000 1500402000 15 Wheat, flour 0.100000 1.400 1.000 1500402001 15 Wheat, flour - babyfood 0.100000 1.400 1.000 1500403000 15 Wheat, germ 0.100000 8.000 1.000 1500404000 15 Wheat, bran 0.100000 8.000 1.000 1500405000 15 Wild rice 0.100000 1.000 1.000 0301338000 3A Shallot, bulb 0.100000 1.000 1.000 1901102500 19A Chive, dried leaves 0.100000 1.000 1.000



### Attachment **4 .**  **Chronic Results File** US EPA Ver. 3.16, 03 - 08 - d DEEM - FCID Chronic analysis for PENDIMETHALIN NHANES 2003 - 2008 2 - day Residue file name: C: \ Users \ pbarnes \ Documents \ DEEMRESULTS \ Pendimethalin on Hops and Alfalfa dietary files \ PENDIMETHALIN chronic hops and a lfalfa 7 22 2014.R08 Adjustment factor #2 used. Analysis Date 07 - 22 - 2014/11:50:07 Residue file dated: 07 - 22 - 2014/11:49:32 Reference dose (RfD, Chronic) = .3 mg/kg bw/day COMMENT 1: PENDIMETHALIN Hop s and Alfalfa

=============================================================================== Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.001592 0.5% Hispanic 0.001767 0.6% Non - Hisp - White 0.001559 0.5% Non - Hisp - Black 0.001513 0.5% Non - Hisp - Other 0.001768 0.6% Nursing Infants 0.001819 0.6% Non - Nursing Infants 0.003809 1.3% Female 13+ PREG 0.001443 0.5% Children 1 - 6 0.004253 1.4% Children 7 - 12 0.002154 0.7% Male 13 - 19 0.001399 0.5% Female 13 - 19/NP 0.001266 0.4% Male 20+ 0.001224 0.4% Female 20+/NP 0.001225 0.4% Seniors 55+ 0.001175 0.4% All Infants 0.0031 95 1.1% Female 13 - 50 0.001250 0.4% Children 1 - 2 0.005043 1.7% Children 3 - 5 0.003987 1.3% Children 6 - 12 0.002329 0.8% Youth 13 - 19 0.001332 0.4% Adults 20 - 49 0.001256 0.4% Adults 50 - 99 0.001191 0.4% Female 13 - 49 0.001248 0.4%

-------------------------------------------------------------------------------Pendimethalin Dietary Exposure and Risk Assessment DP Number: 416577

Page 19 of 19 

### References Drinking Water Assessment for Pendimethalin for Cabbage, Asparagus, Bearing Grapes, and Artichoke; DP Barcode D334061; J. B reithaupt ; 05/08/20 07