ex10-4.htm


    Exhibit
      10.4


     

    SECURITY
      AGREEMENT

     

     

    (Patent)

     

    THIS
      SECURITY AGREEMENT
      (PATENT) (“Agreement”),
      is
      entered into and made effective as of January 3, 2008, by and between IR BIOSCIENCES HOLDINGS,
      INC.,
a Delaware corporation with its principal place of business located
      at
      8767 E. Via De Ventura, Suite 190, Scottsdale, AZ 85258 (the “Parent”), and the
      each subsidiary of the Parent listed on Schedule I attached hereto (each a
      “Subsidiary,”
and collectively
      and together with the Parent, the “Company”), in favor
      of the YA GLOBAL INVESTMENTS,
      L.P. (the “Secured
      Party”).

     

     

    WITNESETH:

     

    WHEREAS,
in
      connection with
      the Securities Purchase Agreement by and among the Parent and the Secured Party
      of even date herewith (the “Securities
      Purchase
      Agreement”), the Parent has agreed, upon the terms and subject to the
      conditions of the Securities Purchase Agreement, to issue to the Secured Party
      (i) an aggregate original principal amount of up to $3,000,000 of senior secured
      convertible debentures (the “Convertible
      Debentures”), which shall be convertible into shares of the Parent’s
      Common Stock (the “Conversion Shares”);
      and (ii) warrants (the “Warrants”) to be
      exercisable to acquire additional shares of Common Stock (the “Warrants Shares”)
      initially in that number of shares of Common Stock set forth in the Securities
      Purchase Agreement;

     

    WHEREAS,
to
      induce the Secured
      Party to purchase the Convertible Debentures and enter into the Securities
      Purchase Agreement and the documents entered into in connection therewith,
      (collectively referred to as the “Transaction
      Documents”), each Company hereby grants to the Secured Party a security
      interest, in and to the Patent Collateral (as defined below) to secure all
      of
      the Obligations (as defined below).

     

    WHEREAS,
      in connection with
      the Securities Purchase Agreement, each Company has agreed to provide the
      Secured Party a general security interest in the Pledged Property (as this
      term
      is defined in the Security Agreement by and between each Company and the Secured
      Party, dated January 3, 2008 (together with all amendments, supplements,
      restatements and other modifications, if any, from time to time made thereto,
      the “Security
      Agreement”);

     

    WHEREAS,
      each Company has duly
      authorized the execution, delivery and performance of this
      Agreement;

     

    NOW
      THEREFORE, for good and
      valuable consideration, the receipt of which is hereby acknowledged, the Company
      agrees as follows:

     

    SECTION
      1. Definitions.  Unless
      otherwise defined herein otherwise requires, terms used in this Agreement,
      including its preamble and recitals, have the meanings provided in the
      Securities Purchase Agreement.

     

    (a) “Obligations”
shall
      have the
      meaning assigned to it in the Security Agreement.

     

    SECTION
      2. Grant
      of Security
      Interest.  For good and valuable consideration, the receipt and
      sufficiency of which are hereby acknowledged, to secure the payment and
      performance of all of the Obligations of the Company, the Company does hereby
      mortgage, pledge and hypothecate to the Secured Party and grant to the Secured
      Party a security interest in all of the following property (the “Patent Collateral”), now owned
      and existing:

     

    (a) all
      letters patent and applications for letters patent throughout the world,
      including all patent applications in preparation for filing anywhere in the
      world and including each patent and patent application referred to in Schedule A
      hereto;

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    (b) all
      reissues, divisions, continuations, continuations-in-part, extensions, renewals
      and reexaminations of any of the items described in clause (a);

     

    (c) all
      patent licenses and other agreements providing the Company with the right to
      use
      any of the items of the type referred to in clauses (a) and (b), including
      each
      patent license referred to in Schedule A
      hereto;

     

    (d) the
      right
      to sue third parties for past, present or future infringements of any Patent
      Collateral described in clauses (a) and (b) and, to the extent applicable,
      clause (c); and

     

    (e) all
      proceeds of, and rights associated with, the foregoing, (including license
      royalties and proceeds of infringement suits), and all rights corresponding
      thereto throughout the world.

     

    SECTION
      3. Security
      Agreement.  This Agreement has been executed and delivered by
      each Company for the purpose of recording the security interest of the Secured
      Party in the Patent Collateral relating to patents referred to in Schedule A with the
      United States Patent and Trade Marks Office, to the extent it may be so
      registered therein.  The security interest granted hereby has been
      granted as a supplement to, and not in limitation of, the security interest
      granted to the Secured Party under the Security Agreement.  The
      Security Agreement (and all rights and remedies of the Secured Party thereunder)
      shall remain in full force and effect in accordance with its terms.

     

    SECTION
      4. Release
      of Security
      Interest.  Upon payment in full of all Obligations the Secured
      Party shall, at the Company’s expense, execute and deliver to the Company all
      instruments and other documents as may be necessary or proper to release the
      lien on any security interest in the Patent Collateral which has been granted
      hereunder.

     

    SECTION
      5. Acknowledgement.  The
      Company does hereby further acknowledge and affirm that the rights and remedies
      of the Secured Party with respect to the security interest in the Patent
      Collateral granted hereby are more fully set forth in the Security Agreement,
      the terms and provisions of which (including the remedies provided for therein)
      are incorporated by references herein as if fully set forth herein.

     

    SECTION
      6. Securities
      Purchase
      Agreement.  Notwithstanding any other term or provision hereof,
      in the event that any provisions hereof contradict and are incapable of being
      construed in conjunction with the provisions of the Securities Purchase
      Agreement, the provisions of the Securities Purchase Agreement shall take
      precedence over those contained herein and, in particular, if any act of the
      Company is expressly permitted under the Securities Purchase Agreement but
      is
      prohibited hereunder, any such act shall be permitted hereunder and any
      encumbrance expressly permitted under the Securities Purchase Agreement to
      exist
      or to remain outstanding shall be permitted hereunder and thereunder. This
      instrument, document or agreement may be sold, assigned or transferred by the
      Agent in accordance with the terms of the Securities Purchase
      Agreement.

     

    SECTION
      7. Counterparts.  This
      Agreement may be executed by the parties hereto in several counterparts, each
      of
      which shall be deemed to be an original and all of which shall constitute
      together but one and the same agreement.

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    IN
      WITNESS WHEREOF, the
      parties hereto have executed this Security Agreement as of the date first above
      written

     

    
      	 	
              IR
                Biosciences Holdings, Inc.

            
	 	 
	 	
              By:      /s/
                Michael
                Wilhelm                                                

            
	 	
              Name:       Michael
                Wilhelm

            
	 	
              Title:        
                President and Chief Executive Officer

            
	 	 
	 	 


    

    


    


    STATE
      OF ____________________)

    )
      SS:

    COUNTY
      OF __________________)

    


    BEFORE
      ME, a Notary Public in
      and for said County and State, personally appeared the above-named Michael
      Wilhelm who acknowledged that he/she did sign the foregoing agreement and that
      the same is his/her free act and deed.

     

    IN
      TESTIMONY WHEREOF, I have
      hereunto set my hand an official seal at __________________,
      ____________________, this ___ day of __________, 2007.

     

    
      	 	/s/
              Michelle R.
              Laroche                                                    
              
	 	
              Notary
                Public

            


    

    


     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    IN
      WITNESS WHEREOF, the
      parties hereto have executed this Security Agreement as of the date first above
      written.

     

    


    
      	 	
              COMPANY:

            
	 	
              ImmuneRegen
                BioSciences, Inc.

            
	 	 
	 	
              By:     /s/
                Michael
                Wilhelm                                  

            
	 	
              Name:      Michael
                Wilhelm

            
	 	
              Title:       
                President and Chief Executive Officer

            
	 	 


    

    


     

    STATE
      OF ____________________)

    )
      SS:

    COUNTY
      OF __________________)

    


    BEFORE
      ME, a Notary Public in
      and for said County and State, personally appeared the above-named Michael
      Wilhelm who acknowledged that he/she did sign the foregoing agreement and that
      the same is his/her free act and deed.

     

    IN
      TESTIMONY WHEREOF, I have
      hereunto set my hand an official seal at __________________,
      ____________________, this ___ day of __________, 2007.

     

    
      	 	/s/
              Michelle R.
              Laroche                        
              
	 	
              Notary
                Public

            


    

    


     

    


     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    


     

     IN
      WITNESS WHEREOF, the
      parties hereto have executed this Security Agreement as of the date first above
      written.

     

    


    
      	 	 
	 	
              SECURED
                PARTY:

            
	 	
              YA
                GLOBAL INVESTMENTS, L.P.

            
	 	 
	 	
              By:      Yorkville
                Advisors, LLC

            
	 	
              Its:      
                Investment Manager

            
	 	 
	 	
              By:       /s/
                Mark
                Angelo                                            

            
	 	
              Name:       
                Mark Angelo

            
	 	
              Title:          Portfolio
                Manager

            
	 	 


    

     

    
 

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    SCHEDULE
      I

    LEGAL
      NAMES; ORGANIZATIONAL
      IDENTIFICATION NUMBERS; STATES OF ORGANIZATION

     

    
      
        	
                 Company’s
                  Name

              	
                State
                  of Organization

              	
                Employer
                  ID

              	
                Organizational
                  ID

              
	
                IR
                  Biosciences Holdings, Inc.

              	
                Delaware

              	
                13-3301889 

                
                

              	
                
                

              
	
                ImmuneRegen
                  BioSciences, Inc.

              	
                Delaware

              	
                11-3666487

              	 


      

    

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    
 

    SCHEDULE
      A

    


    US
      PATENTS AND
      APPLICATIONS

    


    
      


      
        
          	
                  TITLE

                	
                  COUNTRY

                	
                  FILING
                    DATE

                	
                  APPLICATION
                    NUMBER

                	
                  DATE
                    ISSUED

                	
                  PATENT
NUMBER 

                
	
                  
                  

                  Substance
                    P Treatment for
                    Immunostimulation

                	
                  United
                    States of
                    America

                	
                  23-Feb-98

                	
                  09/028003

                	
                  7-Dec-99

                	
                  5998376

                
	
                  Substance
                    P Treatment for
                    Immunostimulation

                	
                  United
                    States of
                    America

                	
                  28-Mar-97

                	
                  08/829445

                	
                  31-Aug-99

                	
                  5945508

                
	
                  Substance
                    P Treatment for
                    Immunostimulation

                	
                  Australia

                	
                  8-Jul-97

                	
                  40464/97

                	
                  22-Nov-01

                	
                  737201

                
	
                  Substance
                    P Treatment for
                    Immunostimulation

                	
                  Canada

                	
                  8-Jul-97

                	
                  2261885

                	 	 
	
                  Substance
                    P Treatment for
                    Immunostimulation

                	
                  Switzerland

                	
                  8-Jul-97

                	
                  97938049

                	
                  24-Mar-04

                	
                  957930

                
	
                  Substance
                    P Treatment for
                    Immunostimulation

                	
                  Germany

                	
                  8-Jul-97

                	
                  97938049

                	
                  24-Mar-04

                	
                  957930

                
	
                  Substance
                    P Treatment for
                    Immunostimulation

                	
                  France

                	
                  8-Jul-97

                	
                  97938049

                	
                  24-Mar-04

                	
                  957930

                
	
                  Substance
                    P Treatment for
                    Immunostimulation

                	
                  Spain

                	
                  8-Jul-97

                	
                  97938049

                	
                  24-Mar-04

                	
                  957930

                
	
                  Substance
                    P Treatment for
                    Immunostimulation

                	
                  United
                    Kingdom

                	
                  8-Jul-97

                	
                  97938049

                	
                  24-Mar-04

                	
                  957930

                
	
                  Substance
                    P Treatment for
                    Immunostimulation

                	
                  Ireland

                	
                  8-Jul-97

                	
                  97938049

                	
                  24-Mar-04

                	
                  957930

                
	
                  Substance
                    P Treatment for
                    Immunostimulation

                	
                  Italy

                	
                  8-Jul-97

                	
                  97938049

                	
                  24-Mar-04

                	
                  957930

                
	
                  Substance
                    P Treatment for
                    Immunostimulation

                	
                  Liechtenstein

                	
                  8-Jul-97

                	
                  97938049

                	
                  24-Mar-04

                	
                  957930

                
	
                  Substance
                    P Treatment for
                    Immunostimulation

                	
                  Monaco

                	
                  8-Jul-97

                	
                  97938049

                	
                  24-Mar-04

                	
                  957930

                
	
                  Amelioration
                    of Effects of
                    Cigarette Smoke

                	
                  United
                    States of
                    America

                	
                  22-Aug-03

                	
                  10/645,839

                	 	 
	
                  Amelioration
                    of Effects of
                    Cigarette Smoke

                	
                  Singapore

                	
                  22-Aug-03

                	
                  200501072-3

                	 	 
	
                  Amelioration
                    of Effects of
                    Cigarette Smoke

                	
                  China

                	
                  22-Aug-03

                	
                  3820184.4

                	 	 
	
                  Amelioration
                    of Effects of
                    Cigarette Smoke

                	
                  Japan

                	
                  22-Aug-03

                	
                  2004-532943

                	 	 
	
                  Amelioration
                    of Effects of
                    Cigarette Smoke

                	
                  European
                    Patent
                    Office

                	
                  22-Aug-03

                	
                  3791722.6

                	 	 
	
                  Amelioration
                    of Effects of
                    Cigarette Smoke

                	
                  Canada

                	
                  22-Aug-03

                	
                  2496447

                	 	 
	
                  Amelioration
                    of Effects of
                    Cigarette Smoke

                	
                  Vietnam

                	
                  22-Aug-03

                	
                  1-2005-00215

                	 	 
	
                  Acute
                    Respiratory
                    Syndromes

                	
                  Hong
                    Kong

                	
                  22-Jun-06

                	
                  6107144.4

                	 	 
	
                  Acute
                    Respiratory
                    Syndromes

                	
                  European
                    Patent
                    Office

                	
                  14-Apr-04

                	
                  4759500.4

                	 	 
	
                  Acute
                    Respiratory
                    Syndromes

                	
                  United
                    States of
                    America

                	
                  14-Oct-05

                	
                  10/553,232

                	 	 
	
                  Acute
                    Respiratory
                    Syndromes

                	
                  Singapore

                	
                  14-Apr-04

                	
                  200507608-8

                	 	 
	
                  Use
                    of Substance P or its Analogs
                    for the Manufacture of Medicaments for Treating or Protecting
                    SARS or
                    ARDS

                	
                  Vietnam

                	
                  14-Apr-04

                	
                  1-2005-01560

                	 	 
	
                  Prevention
                    of Respiratory
                    Infections in Fowl

                	
                  European
                    Patent
                    Office

                	
                  23-Nov-05

                	
                  5849894

                	 	 
	
                  Prevention
                    of Respiratory
                    Infections in Fowl

                	
                  Singapore

                	
                  27-Jan-05

                	
                  200500467-6

                	 	 
	
                  Prevention
                    of Respiratory
                    Infections in Fowl

                	
                  Thailand

                	
                  11-Feb-05

                	
                  97659

                	 	 
	
                  Prevention
                    of Respiratory
                    Infections in Fowl

                	
                  Patent
                    Cooperation
                    Treaty

                	
                  23-Nov-05

                	
                  PCT/US05/42601

                	 	 
	
                  Prevention
                    of Respiratory
                    Infections in Fowl

                	
                  United
                    States of
                    America

                	
                  3-July-07

                	
                  11/795,044

                	 	 
	
                  Prevention
                    of Respiratory
                    Infections in Fowl

                	
                  Australia

                	
                  23-Nov-05

                	
                  2005323304

                	 	 
	
                  Prevention
                    of Respiratory
                    Infections in Fowl

                	
                  Japan

                	
                  23-Nov-05

                	
                  2007-549376

                	 	 
	
                  Prevention
                    of Respiratory
                    Infections in Fowl

                	
                  Canada

                	
                  23-Nov-05

                	
                  2,593,232

                	 	 
	
                  Prevention
                    of Respiratory
                    Infections in Fowl

                	
                  Vietnam

                	
                  5-May-05

                	
                  1-2005-00599

                	 	 
	
                  Treatment
                    of Skin
                    Diseases

                	
                  European
                    Patent
                    Office

                	
                  15-Dec-05

                	
                  5854144.2

                	 	 
	
                  Treatment
                    of Skin
                    Diseases

                	
                  Singapore

                	
                  27-Jan-05

                	
                  200500466-8

                	 	 
	
                  Treatment
                    of Skin
                    Diseases

                	
                  Vietnam

                	
                  5-May-05

                	
                  1-2005-00598

                	 	 
	
                  Treatment
                    of Skin
                    Diseases

                	
                  Thailand

                	
                  25-Feb-05

                	
                  98080

                	 	 
	
                  Treatment
                    of Skin
                    Diseases

                	
                  Canada

                	
                  15-Dec-05

                	
                  2594517

                	 	 
	
                  Treatment
                    of Skin
                    Diseases

                	
                  Australia

                	
                  15-Dec-05

                	
                  2005324417

                	 	 
	
                  Treatment
                    of Skin
                    Diseases

                	
                  Patent
                    Cooperation
                    Treaty

                	
                  15-Dec-05

                	
                  PCT/US05/45369

                	 	 
	
                  Method
                    to Promote Wound
                    Healing

                	
                  European
                    Patent
                    Office

                	
                  25-Oct-05

                	
                  5813067.5

                	 	 


           

           

           

          
            
              
              

            

            
              
              

              
                

              

            

            
              
              

            

          

           

          	
                  Method
                    to Promote Wound
                    Healing

                	
                  Australia

                	
                  25-Oct-05

                	
                  2005299341

                	 	 
	
                  Method
                    to Promote Wound
                    Healing

                	
                  Japan

                	
                  25-Oct-05

                	
                  2007-539081

                	 	 
	
                  Method
                    to Promote Wound
                    Healing

                	
                  Canada

                	
                  25-Oct-05

                	
                  2585265

                	 	 
	
                  Method
                    to Promote Wound
                    Healing

                	
                  Patent
                    Cooperation
                    Treaty

                	
                  25-Oct-05

                	
                  PCT/US05/38646

                	 	 
	
                  Method
                    to Promote Wound
                    Healing

                	
                  United
                    States of
                    America

                	
                  27-Apr-07

                	
                  11/666,474

                	 	 
	
                  Treatment
                    for
                    Asthma

                	
                  Patent
                    Cooperation
                    Treaty

                	
                  31-Mar-06

                	
                  PCT/US06/011833

                	 	 
	
                  Treatment
                    for
                    Asthma

                	
                  European
                    Patent
                    Office

                	
                  31-Mar-06

                	
                  6748998.9

                	 	 
	
                  Treatment
                    for
                    Asthma

                	
                  Japan

                	
                  31-Mar-06

                	
                  tba

                	 	 
	
                  Treatment
                    for
                    Asthma

                	
                  Australia

                	
                  31-Mar-06

                	
                  tba

                	 	 
	
                  Treatment
                    for
                    Asthma

                	
                  Canada

                	
                  31-Mar-06

                	
                  tba

                	 	 
	
                  Treatment
                    for
                    Asthma

                	
                  Singapore

                	
                  24-Jun-05

                	
                  200504104-1

                	 	 
	
                  Treatment
                    for
                    Asthma

                	
                  United
                    States of
                    America

                	
                  25-Sep-07

                	
                  11/887,105

                	 	 
	
                  Stimulation
                    of Hair
                    Growth

                	
                  United
                    States of
                    America

                	
                  20-Jun-05

                	
                  10/539,734

                	 	 
	
                  Stimulation
                    of Hair
                    Growth

                	
                  Patent
                    Cooperation
                    Treaty

                	
                  18-Dec-03

                	
                  PCT/US03/40259

                	 	 
	
                  Inducing
                    and Maintaining Hair
                    Color

                	
                  United
                    States of
                    America

                	
                  25-Oct-06

                	
                  11/587,594

                	 	 
	
                  Inducing
                    and Maintaining Hair
                    Color

                	
                  Patent
                    Cooperation
                    Treaty

                	
                  18-Apr-05

                	
                  PCT/US05/13112

                	 	 
	
                  Anti-Aging
                    Effects of Substance
                    P

                	
                  Patent
                    Cooperation
                    Treaty

                	
                  18-Apr-05

                	
                  PCT/US05/13113

                	 	 
	
                  Anti-Aging
                    Effects of Substance
                    P

                	
                  Japan

                	
                  18-Apr-05

                	
                  2007-509540

                	 	 
	
                  Anti-Aging
                    Effects of Substance
                    P

                	
                  Canada

                	
                  18-Apr-05

                	
                  tba

                	 	 
	
                  Anti-Aging
                    Effects of Substance
                    P

                	
                  United
                    States of
                    America

                	
                  25-Oct-06

                	
                  PCT/US05/13113

                	 	 
	
                  Anti-Aging
                    Effects of Substance
                    P

                	
                  European
                    Patent
                    Office

                	
                  18-Apr-05

                	
                  5755488.3

                	 	 
	
                  Anti-Aging
                    Effects of Substance
                    P

                	
                  China

                	
                  18-Apr-05

                	
                  2005-80016786.5

                	 	 
	
                  Anti-Aging
                    Effects of Substance
                    P

                	
                  Australia

                	
                  18-Apr-05

                	
                  2005240026

                	 	 
	
                  Method
                    to Reduce the Risk and/or
                    Severity of Anthrax Infection

                	
                  Patent
                    Cooperation
                    Treaty

                	
                  6-Mar-07

                  
                  

                	
                  PCT/US07/05668

                  
                  

                	 	 
	
                  Method
                    to Reduce the Risk and/or
                    Severity of Anthrax Infection

                	
                  United
                    States of
                    America

                  
                  

                	
                  2-Feb
                    07

                	
                  60/889,035

                	 	 
	
                  Prophylactic
                    and Therapeutic
                    Treatment of Mammals
                    for Avian
                    InfluenzaVirus
                    Infection

                	
                  Patent
                    Cooperation
                    Treaty

                	
                  14-Aug-07

                  
                  

                	
                  PCT/US07/017953

                  
                  

                	 	 
	
                  Prophylactic
                    and Therapeutic
                    Treatment of Mammals
                    for Avian
                    InfluenzaVirus
                    Infection

                	
                  United
                    States of
                    America

                  
                  

                	
                  1-May-07

                	
                  60/915,373

                	 	 
	
                  Prophylactic
                    and Therapeutic
                    Treatment of Mammals
                    for Avian
                    InfluenzaVirus
                    Infection

                	
                  United
                    States of
                    America

                  
                  

                	
                  15-Aug-06

                	
                  60/837,635

                	 	 
	
                  Prophylactic
                    and Therapeutic
                    Treatment of Mammals
                    for Avian
                    InfluenzaVirus
                    Infection

                	
                  United
                    States of
                    America

                  
                  

                	
                  9-Oct-06

                	
                  60/828,728

                	 	 
	
                  Prophylactic
                    and Therapeutic
                    Treatment of Mammals
                    for Avian
                    InfluenzaVirus
                    Infection

                	
                  United
                    States of
                    America

                  
                  

                	
                  22-Nov-06

                	
                  60/866,901

                	 	 
	
                  Method
                    to Treat Blood Cell
                    Depletion

                	
                  Patent
                    Cooperation
                    Treaty

                	
                  30-May-07

                	
                  PCT/US
                    tba

                	 	 
	
                  Method
                    to Treat Blood Cell
                    Depletion, In Conditions Such as MDS

                	
                  United
                    States of
                    America

                  
                  

                	
                  27-Jul-07

                	
                  60/952,394

                	 	 
	
                  Method
                    to Stimulates Blood Cells
                    Regeneration Following Non-Lethal Radiation
                    Exposure

                	
                  United
                    States of
                    America

                  
                  

                	
                  30-Jul-07

                	
                  0/952,691

                   

                	 	 
	
                  Substance
                    P and Analogs
                    Thereofas aVaccine  Adjuvant

                	
                  United
                    States of
                    America

                	
                  18-Jan-07

                	
                  60/885,562

                	 	 
	
                  Substance
                    P as an Adjuvant

                	
                  United
                    States of
                    America

                	
                  14-Aug-07

                	
                  60/955,712

                	 	 
	
                  Use
                    of Homspera
                    (substance P
                    analog) as an
                    Adjuvant

                	
                  United
                    States of
                    America

                	
                  1-May-07

                	
                  60/915,358

                	 	 
	
                  Methods
                    of Using Substance P and
                    Analogs for Ameliorating Adverse Effects of Drugs

                	
                  United
                    States of
                    America

                	
                  20-Aug-07

                  
                  

                	
                  60/965,580

                  
                  

                  
                  

                	 	 
	
                  Substance
                    P Analogs
                    as PARP
                    Inhibitors

                	
                  United
                    States of
                    America

                  
                  

                	
                  29-Aug-07

                  
                  

                	
                  60/966,948

                	 	 
	
                  Substance
                    P Analogs
                    to Promote Cell
                    Differentiation

                	
                  United
                    States of
                    America

                  
                  

                	
                  2-Oct-07

                  
                  

                  
                  

                	
                  60/997,314

                	 	 
	
                  Methods
                    of Stimulating the
                    Proliferation and/or Differentiation of Stem Cells withSubstance
                    P, or an
                    

                  Analog

                	
                  United
                    States of
                    America

                  
                  

                	
                  26-Oct-07

                	
                  60/983,012

                  
                  

                	 	 
	
                  Substance
                    P Analogs
                    to Stimulate Fibroblast
                    Growth

                	
                  United
                    States of
                    America

                  
                  

                	
                  12-Oct-07

                  
                  

                	
                  60/979,769

                  
                  

                	 	 
	
                  Methods
                    and Compositions for
                    Improving the Texture or Appearance of Skin with Substance P
                    or an Analog
                    Thereof

                	
                  United
                    States of
                    America

                  
                  

                	
                  21-Dec-07

                	
                  61/016,245

                	 	 
	
                  ELISA
                    for Substance P
                    Analogs

                	
                  United
                    States of
                    America

                  
                  

                	
                  tba