Federal Register / Vol. 72, No. 94 / Wednesday, May 16, 2007 / Notices 27559 

I. General Information 

A. Does this Action Apply to Me? 

You may be potentially affected by 

this action if you are required to 

conduct testing of chemical substances 

under the Toxic Substances Control Act 

(TSCA), the Federal Food, Drug and 

Cosmetic Act (FFDCA), or the Federal 

Insecticide, Fungicide, and Rodenticide 

Act (FIFRA). Since other entities may 

also be interested, the Agency has not 

attempted to describe all the specific 

entities that may be affected by this 

action. If you have any questions 

regarding the applicability of this action 

to a particular entity, consult the person 

listed under FOR FURTHER INFORMATION

CONTACT. 

B. How Can I Get Copies of this 

Document and Other Related 

Information? 

1. Docket. EPA has established a 

docket for this action under docket 

identification (ID) number EPA–HQ–

OPP–2007–0319. Publicly available 

docket materials are available either in 

the electronic docket at http:// 

www.regulations.gov, or, if only 

available in hard copy, at the Office of 

Pesticide Programs (OPP) Regulatory 

Public Docket in Rm. S-4400, One 

Potomac Yard (South Bldg.), 2777 S. 

Crystal Drive Arlington, VA. The hours 

of operation of this Docket Facility are 

from 8:30 a.m. to 4 p.m., Monday 

through Friday, excluding legal 

holidays. The Docket Facility telephone 

number is (703) 305-5805. 

2. Electronic access. You may access 

this Federal Register document 

electronically through the EPA Internet 

under the ‘‘Federal Register’’ listings at 

http://www.epa.gov/fedrgstr. 

II. Background 

On a triannual interval, an Exposure 

Modeling Public Meeting will be held 

for presentation and discussion of 

current issues in modeling pesticide 

fate, transport, and exposure in support 

of risk assessment in a regulatory 

context. Meeting dates and abstract 

requests are announced through the 

‘‘empmlist’’ forum on the LYRIS list 

server at: https://lists.epa.gov/read/ 

all_forums/. 

III. How Can I Request to Participate in 

this Meeting? 

You may submit a request to 

participate in this meeting to the person 

listed under FOR FURTHER INFORMATION

CONTACT. Do not submit any information 

in your request that is considered CBI. 

Requests to participate in the meeting, 

identified by docket ID number EPA–

HQ–OPP–2007–0319, must be received 

on or before May 31, 2007. 

IV. Tentative Agenda 

9 a.m. Welcome, Introductions, and 

Brief Updates 

9:30 a.m. Model Review and Scenario 

Development for Urban Pesticide Runoff 

Model (Scott Jackson, CLA; Mark 

Cheplick, Amy Ritter and Marty 

Williams, WEI) 

10 a.m. Urban Models: Concepts, 

Questions and Opportunities (Tharacad 

Ramanarayanan, Bayer and Paul 

Hendley, Syngenta) 

10:45 a.m. Examination of NonAgricultural Pesticide Use by means of 

GIS Coverages (Roy W. Meyer & Curtis 

Brown, New Jersey Department of 

Environmental Protection) 

11:15 a.m. A Comparison of PRZM, 

RZWQM, AND TURFPQ for Modeling 

Turf Pesticides (Qingli Ma and Stuart 

Cohen, Environmental & Turf Services, 

Inc.) 

11:45 a.m. Lunch 

1 p.m. Methods for Estimating Spatial 

Distributions of Turf (Michelle Thawley, 

USEPA/EFED) 

1:30 p.m. National PCA assessment 

for turf (Gerco Hoogeweg, Raghu 

Vamshi, and Marty Williams, 

Waterborne Environmental, Inc.) 

2:15 p.m. Update on the Drift 

Reduction Technology (DRT) project 

(Faruque Khan and Norm Birchfield, 

USEPA/EFED) 

2:45 p.m. Wrap-up 

List of Subjects 

Environmental protection, Modeling, 

Pesticides, Pest. 

Dated: May 8, 2007. 

Steven Bradbury, 

Director, Environmental Fate and Effects 

Division, Office of Pesticide Programs. 

[FR Doc. E7–9322 Filed 5–15–07; 8:45 am] 

BILLING CODE 6560–50–S 

ENVIRONMENTAL PROTECTION 

AGENCY 

[EPA–HQ–OPP–2007–0388; FRL–8131–2] 

FIFRA Scientific Advisory Panel; 

Notice of Public Meeting 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Notice. 

SUMMARY: There will be a 4–day 

meeting of the Federal Insecticide, 

Fungicide, and Rodenticide Act 

Scientific Advisory Panel (FIFRA SAP) 

to review a set of issues being 

considered by the Agency pertaining to 

two separate topics. On August 14-15, 

2007, the Panel will consider a Review 

of EPA/ORD/NERL’s SHEDSMultimedia Model, aggregate version 3. 

On August 16-17, 2007, the Panel will 

review Assessing Approaches for the 

Development of PBPK Models of 

Pyrethroid Pesticides. 

DATES: The meeting will be held on 

August 14-17, 2007, from 8:30 a.m. to 5 

p.m, eastern standard time (est.) 

Comments. The Agency encourages 

that written comments be submitted by 

July 31, 2007 and requests for oral 

comments be submitted by August 7, 

2007. However, written comments and 

requests to make oral comments may be 

submitted until the date of the meeting. 

For additional instructions, see Unit I.C. 

of the SUPPLEMENTARY INFORMATION. 

Nominations. Nominations of 

candidates to serve as ad hoc members 

of the FIFRA SAP for this meeting 

should be provided on or before May 29, 

2007. 

Special accommodations. For 

information on access or services for 

individuals with disabilities, and to 

request accommodation of a disability, 

please contact the Designated Federal 

Official (DFO) listed under FOR FURTHER

INFORMATION CONTACT at least 10 days 

prior to the meeting to give EPA as 

much time as possible to process your 

request. 

ADDRESSES: The meeting will be held at 

the Environmental Protection Agency 

Conference Center, Lobby Level, One 

Potomac Yard (South Bldg.), 2777 

Crystal Dr., Arlington, VA 22202. 

Comments. Submit your comments, 

identified by docket ID number EPA–

HQ–OPP–2007–0388, by one of the 

following methods: 

• Federal eRulemaking Portal: http:// 

www.regulations.gov. Follow the on-line 

instructions for submitting comments. 

Your use of the Federal eRulemaking 

Portal to submit comments to EPA 

electronically is EPA’s preferred method 

for receiving comments. 

• Mail. Office of Pesticide Programs 

(OPP) Regulatory Public Docket (7502P), 

Environmental Protection Agency, 1200 

Pennsylvania Ave., NW., Washington, 

DC 20460-0001. 

• Delivery. OPP Regulatory Public 

Docket (7502P), Environmental 

Protection Agency, Rm. S-4400, One 

Potomac Yard (South Bldg), 2777 S. 

Crystal Dr., Arlington, VA. Deliveries 

are only accepted during the Docket’s 

normal hours of operation 8:30 a.m. to 

4 p.m., Monday through Friday, 

excluding legal holidays. Special 

arrangements should be made for 

deliveries of boxed information. The 

Docket Facility telephone number is 

(703) 305-5805. 


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Instructions. Direct your comments to 

docket ID number EPA–HQ–OPP–2007–

0388. If your comments contain any 

information that you consider to be CBI 

or otherwise protected, please contact 

the DFO listed under FOR FURTHER

INFORMATION CONTACT to obtain special 

instruction before submitting your 

comments. EPA’s policy is that all 

comments received will be included in 

the docket without change and may be 

made available on-line at http:// 

www.regulations.gov, including any 

personal information provided, unless 

the comment includes information 

claimed to be Confidential Business 

Information (CBI) or other information 

whose disclosure is restricted by statute. 

Do not submit information that you 

consider to be CBI or otherwise 

protected through regulations.gov or email. The regulations.gov website is an 

‘‘anonymous access’’ system, which 

means EPA will not know your identity 

or contact information unless you 

provide it in the body of your comment. 

If you send an e-mail comment directly 

to EPA without going through 

regulations.gov, your e-mail address 

will be automatically captured and 

included as part of the comment that is 

placed in the docket and made available 

on the Internet. If you submit an 

electronic comment, EPA recommends 

that you include your name and other 

contact information in the body of your 

comment and with any disk or CD ROM 

you submit. If EPA cannot read your 

comment due to technical difficulties 

and cannot contact you for clarification, 

EPA may not be able to consider your 

comment. Electronic files should avoid 

the use of special characters, any form 

of encryption, and be free of any defects 

or viruses. 

Docket. All documents in the docket 

are listed in a docket index available in 

regulations.gov. To access the electronic 

docket, go to http:// 

www.regulations.gov, select ‘‘Advanced 

Search,’’ then ‘‘Docket Search.’’ Insert 

the docket ID number where indicated 

and select the ‘‘Submit’’ button. Follow 

the instructions on the regulations.gov 

web site to view the docket index or 

access available documents. Although, 

listed in a docket index, some 

information is not publicly available, 

e.g., CBI or other information whose 

disclosure is restricted by statute. 

Certain other material, such as 

copyrighted material, is not placed on 

the Internet and will be publicly 

available only in hard copy form. 

Publicly available docket materials are 

available in the electronic docket at 

http://www.regulations.gov, or if only 

available in hard copy, at the OPP 

Regulatory Public Docket in Rm. S-4400, 

One Potomac Yard (South Bldg), 2777 S. 

Crystal Dr., Arlington, VA. The hours of 

operation of this Docket Facility are 

from 8:30 a.m. to 4 p.m., Monday 

through Friday, excluding legal 

holidays. The Docket Facility telephone 

number is (703) 305-5805. 

Nominations, requests to present oral 

comments, and requests for special 

accommodations. Submit nominations 

to serve as an ad hoc member of the 

FIFRA SAP, requests for special seating 

accommodations, or requests to present 

oral comments to the DFO listed under 

FOR FURTHER INFORMATION CONTACT. 

FOR FURTHER INFORMATION CONTACT: 

Steve M. Knott, DFO, Office of Science 

Coordination and Policy (7201M), 

Environmental Protection Agency, 1200 

Pennsylvania Ave., NW., Washington, 

DC 20460; telephone number: (202) 564- 

0103; fax number: (202) 564-8382; email addresses: knott.steven@epa.gov. 

SUPPLEMENTARY INFORMATION: 

I. General Information 

A. Does this Action Apply to Me? 

This action is directed to the public 

in general. This action may, however, be 

of interest to persons who are or may be 

required to conduct testing of chemical 

substances under the Federal Food, 

Drug, and Cosmetic Act (FFDCA), 

FIFRA, and the Food Quality Protection 

Act of 1996 (FQPA). Since other entities 

may also be interested, the Agency has 

not attempted to describe all the specific 

entities that may be affected by this 

action. If you have any questions 

regarding the applicability of this action 

to a particular entity, consult the DFO 

listed under FOR FURTHER INFORMATION

CONTACT. 

B. What Should I Consider as I Prepare 

My Comments for EPA? 

When submitting comments, 

remember to: 

1. Identify the document by docket ID 

number and other identifying 

information (subject heading, Federal 

Register date and page number). 

2. Follow directions. The Agency may 

ask you to respond to specific questions 

or organize comments by referencing a 

Code of Federal Regulations (CFR) part 

or section number. 

3. Explain why you agree or disagree; 

suggest alternatives and substitute 

language for your requested changes. 

4. Describe any assumptions and 

provide any technical information and/ 

or data that you used. 

5. If you estimate potential costs or 

burdens, explain how you arrived at 

your estimate in sufficient detail to 

allow for it to be reproduced. 

6. Provide specific examples to 

illustrate your concerns and suggest 

alternatives. 

7. Explain your views as clearly as 

possible, avoiding the use of profanity 

or personal threats. 

8. Make sure to submit your 

comments by the comment period 

deadline identified. 

C. How May I Participate in this 

Meeting? 

You may participate in this meeting 

by following the instructions in this 

unit. To ensure proper receipt by EPA, 

it is imperative that you identify docket 

ID number EPA–HQ–OPP–2007–0388 in 

the subject line on the first page of your 

request. 

1. Written comments. The Agency 

encourages that written comments be 

submitted, using the instructions in 

ADDRESSES, no later than July 31, 2007, 

to provide FIFRA SAP the time 

necessary to consider and review the 

written comments. However, written 

comments are accepted until the date of 

the meeting. Persons wishing to submit 

written comments at the meeting should 

contact the DFO listed under FOR

FURTHER INFORMATION CONTACT and 

submit 30 copies. There is no limit on 

the extent of written comments for 

consideration by FIFRA SAP. 

2. Oral comments. The Agency 

encourages that each individual or 

group wishing to make brief oral 

comments to FIFRA SAP submit their 

request to the DFO listed under FOR

FURTHER INFORMATION CONTACT no later 

than August 7, 2007, in order to be 

included on the meeting agenda. 

Requests to present oral comments will 

be accepted until the date of the meeting 

and, to the extent that time permits, the 

Chair of the FIFRA SAP may permit the 

presentation of oral comments at the 

meeting by interested persons who have 

not previously requested time. The 

request should identify the name of the 

individual making the presentation, the 

organization (if any) the individual will 

represent, and any requirements for 

audiovisual equipment (e.g., overhead 

projector, 35 mm projector, chalkboard). 

Oral comments before FIFRA SAP are 

limited to approximately 5 minutes 

unless prior arrangements have been 

made. In addition, each speaker should 

bring 30 copies of his or her comments 

and presentation slides for distribution 

to the FIFRA SAP at the meeting. 

3. Seating at the meeting. Seating at 

the meeting will be on a first-come 

basis. 

4. Request for nominations to serve as 

ad hoc members of the FIFRA SAP for 

this meeting. As part of a broader 

process for developing a pool of 


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candidates for each meeting, the FIFRA 

SAP staff routinely solicits the 

stakeholder community for nominations 

of prospective candidates for service as 

ad hoc members of the FIFRA SAP. Any 

interested person or organization may 

nominate qualified individuals to be 

considered as prospective candidates for 

a specific meeting. Individuals 

nominated for this meeting should have 

expertise in one or more of the 

following areas: Dietary and residential 

exposure modeling, probabilistic 

exposure assessment, statistics, risk 

assessment with experience 

understanding the data needed for risk 

assessment purposes, how to interpret 

the data, and issues concerning intraspecies and inter-species extrapolation, 

pharmacokinetics with experience in 

the development and application of 

PBPK models, and metabolism with 

experience in the use of in vitro 

approaches for species extrapolation. 

Nominees should be scientists who have 

sufficient professional qualifications, 

including training and experience, to be 

capable of providing expert comments 

on the scientific issues for this meeting. 

Nominees should be identified by name, 

occupation, position, address, and 

telephone number. Nominations should 

be provided to the DFO listed under FOR

FURTHER INFORMATION CONTACT on or 

before May 29, 2007]. The Agency will 

consider all nominations of prospective 

candidates for this meeting that are 

received on or before this date. 

However, final selection of ad hoc 

members for this meeting is a 

discretionary function of the Agency. 

The selection of scientists to serve on 

the FIFRA SAP is based on the function 

of the panel and the expertise needed to 

address the Agency’s charge to the 

panel. No interested scientists shall be 

ineligible to serve by reason of their 

membership on any other advisory 

committee to a Federal department or 

agency or their employment by a 

Federal department or agency except the 

EPA. Other factors considered during 

the selection process include 

availability of the potential panel 

member to fully participate in the 

panel’s reviews, absence of any conflicts 

of interest or appearance of lack of 

impartiality, independence with respect 

to the matters under review, and lack of 

bias. Although, financial conflicts of 

interest, the appearance of lack of 

impartiality, lack of independence, and 

bias may result in disqualification, the 

absence of such concerns does not 

assure that a candidate will be selected 

to serve on the FIFRA SAP. Numerous 

qualified candidates are identified for 

each panel. Therefore, selection 

decisions involve carefully weighing a 

number of factors including the 

candidates’ areas of expertise and 

professional qualifications and 

achieving an overall balance of different 

scientific perspectives on the panel. 

In order to have the collective breadth 

of experience needed to address the 

Agency’s charge for this meeting, the 

Agency anticipates selecting 

approximately 10 ad hoc scientists for 

each topic. FIFRA SAP members are 

subject to the provisions of 5 CFR part 

2634, Executive Branch Financial 

Disclosure, as supplemented by the EPA 

in 5 CFR part 6401. In anticipation of 

this requirement, prospective 

candidates for service on the FIFRA 

SAP will be asked to submit 

confidential financial disclosure 

information which shall fully disclose, 

among other financial interests, the 

candidate’s employment, stocks and 

bonds, and where applicable, sources of 

research support. The EPA will evaluate 

the candidates financial disclosure form 

to assess whether there are financial 

conflicts of interest, appearance of a 

lack of impartiality or any prior 

involvement with the development of 

the documents under consideration 

(including previous scientific peer 

review) before the candidate is 

considered further for service on the 

FIFRA SAP. Those who are selected 

from the pool of prospective candidates 

will be asked to attend the public 

meetings and to participate in the 

discussion of key issues and 

assumptions at these meetings. In 

addition, they will be asked to review 

and to help finalize the meeting 

minutes. The list of FIFRA SAP 

members participating at this meeting 

will be posted on the FIFRA SAP web 

site at http://epa.gov/scipoly/sap or may 

be obtained from the OPP Regulatory 

Public Docket at http:// 

www.regulations.gov. 

II. Background 

A. Purpose of the FIFRA SAP 

The FIFRA SAP serves as the primary 

scientific peer review mechanism of 

EPA, Office of Prevention, Pesticides 

and Toxic Substances and is structured 

to provide scientific advice, information 

and recommendations to the EPA 

Administrator on pesticides and 

pesticide-related issues as to the impact 

of regulatory actions on health and the 

environment. The FIFRA SAP is a 

Federal advisory committee established 

in 1975 under FIFRA that operates in 

accordance with requirements of the 

Federal Advisory Committee Act. The 

FIFRA SAP is composed of a permanent 

panel consisting of seven members who 

are appointed by the EPA Administrator 

from nominees provided by the National 

Institutes of Health and the National 

Science Foundation. FIFRA, as 

amended by the FQPA of 1996, 

established a Science Review Board 

consisting of at least 60 scientists who 

are available to the Scientific Advisory 

Panel on an ad hoc basis to assist in 

reviews conducted by the Panel. As a 

peer review mechanism, the FIFRA SAP 

provides comments, evaluations and 

recommendations to improve the 

effectiveness and quality of analyses 

made by Agency scientists. Members of 

the FIFRA SAP are scientists who have 

sufficient professional qualifications, 

including training and experience, to 

provide expert advice and 

recommendation to the Agency. 

B. Public Meeting 

The FQPA amended laws under 

which EPA evaluates the safety of 

pesticide residues in food. Section 

408(b)(2)(D)(v) and (vi) of the FFDCA as 

amended by FQPA, specifies that when 

determining the safety of a pesticide 

chemical, EPA shall consider aggregate 

exposure (i.e., total dietary (food and 

water), residential, and other nonoccupational) and available information 

concerning the cumulative effects to 

human health that may result from 

exposure to other substances that have 

a common mechanism of toxicity. 

Pyrethroid pesticides are currently 

undergoing evaluation to determine if a 

cumulative risk assessment is warranted 

for this class of chemicals. As part of 

this evaluation, EPA will utilize the 

SHEDS probabilistic model to estimate 

cumulative exposure to pyrethroid 

pesticides; also, EPA is developing 

physiologically-based pharmacokinetic 

(PBPK) models to aid in quantitatively 

assessing exposure dose response 

relationships for individual pyrethroids 

and mixtures. 

The FIFRA SAP will meet to review 

the following scientific issues: 

1. Review of EPA/ORD/NERL’s 

SHEDS-Multimedia Model, aggregate 

version 3: The purpose of this review is 

to request input from the SAP on EPA/ 

ORD/NERL’s Stochastic Human 

Exposure and Dose Simulation for 

Multimedia, Multipathway Pollutants 

(SHEDS-Multimedia), aggregate version 

3. SHEDS-Multimedia version 3 is a 

state-of-science computer model for 

simulating human exposures to 

multimedia, multipathway 

environmental pollutants including 

pesticides. It is a physically-based, 

probabilistic model that predicts, for 

user-specified population cohorts, 

exposures incurred via eating 

contaminated foods or drinking water, 


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inhaling contaminated air, touching 

contaminated surface residues, and 

ingesting residues from hand- to-mouth 

or object- to-mouth activities. To do 

this, it combines information on 

chemical usage, human activity data 

(e.g., from Consolidated Human Activity 

Database (CHAD) time/activity diary 

surveys and videography studies), 

environmental residues and 

concentrations, and exposure factors to 

generate time series of exposure for 

simulated individuals. One-stage or 

two-stage Monte Carlo simulation is 

used to produce distributions of 

exposure for various population cohorts 

(e.g., age/gender groups) that reflect the 

variability and/or uncertainty in the 

input parameters. While the core of 

SHEDS-Multimedia is the 

concentration-to-exposure module, 

there are various options (built-in 

source-to-concentration module; userentered time series from other models or 

field study measurements) for obtaining 

concentration inputs, and SHEDSMultimedia exposure outputs can be 

used as inputs to PBPK models. 

Finally, the SHEDS-Multimedia 

version 3 single chemical model can 

address many useful aspects of 

aggregate and cumulative risk 

assessment, related to population 

aggregate exposures for different 

multimedia chemicals and the 

important contributing pathways and 

factors. Such information will be useful 

in identifying populations and exposure 

scenarios of greatest concern for this 

class of chemicals. These populations 

and exposure scenarios will in turn be 

used to determine the most relevant 

chemical/pyrethroid combinations for 

which hazard/exposure factors 

information will need further 

development in order to support a PBPK 

dose modeling approach. EPA plans to 

extend the current single chemical 

aggregate version of SHEDS to a 

cumulative version. The cumulative 

version of SHEDS will be used to 

estimate exposure resulting from 

cumulative exposure to pyrethroid 

pesticides. 

At this meeting, the FIFRA SAP panel 

will be asked to review the following: 

The dietary module of SHEDS version 3; 

the residential module of SHEDS 

version 3; and planned methodologies 

for extending SHEDS-Multimedia 

version 3 (aggregate) to SHEDSMultimedia version 4 (cumulative). 

Review of the dietary module will 

include the methodology and model 

evaluation. Review of the residential 

module will include the SAS code, 

graphic user interface (GUI), technical 

manual, and user manual. Review of the 

planned methodologies to extend the 

single chemical aggregate version of 

SHEDS (version 3) to the cumulative 

version (version 4) will include: 

Algorithms for multiple chemicals and 

co-occurrence; fugacity-based module 

for residential concentration 

predictions; new methodologies for 

enhanced longitudinal activity diary 

simulation; Sobol methodology for 

enhanced sensitivity analyses; planned 

approach for combining residential and 

dietary modules; and planned coding 

and GUI changes for version 4. The 

panel members will not be asked to 

review chemical-specific inputs or 

evaluate outputs at this SAP meeting. 

This SAP review is part of the 

Agency’s ongoing process to enhance 

probabilistic exposure, dose, and risk 

assessments, and OPP’s ongoing efforts 

to consider available probabilistic 

exposure and dose models to address 

FQPA. To assist the FIFRA SAP in their 

review, each FIFRA SAP member will 

be provided technical reports describing 

the SHEDS-Multimedia version 3 

model, annotated SHEDS code, GUI, a 

user guide for the GUI, a technical 

document describing planned 

methodologies for extending version 3 

to version 4, and several relevant 

journal articles for reference. 

2. Assessing Approaches for the 

Development of PBPK Models of 

Pyrethroid Pesticides: The development 

of these models offers many challenges, 

including: 

a. As a class, pyrethroid pesticides 

have many structural similarities such 

that a ‘‘generic’’ model structure, with 

chemical specific adjustments as 

needed, can be developed. Chemical 

specific parameters are anticipated to 

include partition coefficients, hepatic 

clearance rates and others. 

b. It is anticipated that the PBPK 

models will be used for cross-species 

extrapolation of internal dose metrics 

for assessing the risk of pyrethroid 

neurotoxicity. Based on the results of in 

vivo experiments in rats, blood and 

brain concentrations of parent 

compound correlate with pyrethroid 

toxicity as measured by motor activity; 

either of these metrics could be a model 

output for use in a cumulative risk 

assessment. 

c. Pyrethroids may have one or more 

chiral centers resulting in numerous 

stereoisomers. There is limited 

information on the toxicity and 

pharmacokinetics of the different 

stereoisomers. EPA proposes to evaluate 

three modeling assumptions in order to 

address the uncertainties due to chiral 

chemistry of the pyrethroids. 

d. Finally, there is limited human 

data to calibrate and evaluate these 

models for extrapolation to humans. 

EPA proposes to develop the human 

model through the use of computational 

and in vitro experimental approaches 

using human tissue. To evaluate this 

approach, EPA plans to develop 

equivalent rodent and human in vitro 

databases for metabolic and 

physiological parameters for use in the 

PBPK models. The utility of this 

approach will be assessed by comparing 

rodent model predictions to in vivo 

data. It is likely that scaling factors will 

be used in order to incorporate these in 

vitro parameters into the rodent model. 

When calibrating the human data, the 

scaling factors used in the rodent 

models will be used in the human 

models. 

The purpose of this review is to 

request input from the SAP on: 

i. The appropriateness of a generic 

PBPK model, 

ii. Potential dose metrics that are 

relevant for a cumulative risk 

assessment, 

iii. The proposed approach for the 

incorporation of chiral chemistry into 

model structure, and 

iv. The proposed approach for 

developing these models with limited 

human dosimetry data. Planned 

methodologies for linking exposure to 

PBPK will also be discussed. 

C. FIFRA SAP Documents and Meeting 

Minutes 

EPA’s background paper, related 

supporting materials, charge/questions 

to the FIFRA SAP, FIFRA SAP 

composition (i.e., members and ad hoc 

members for this meeting), and the 

meeting agenda will be available by late 

July. In addition, the Agency may 

provide additional background 

documents as the materials become 

available. You may obtain electronic 

copies of these documents, and certain 

other related documents that might be 

available electronically, at http:// 

www.regulations.gov and the FIFRA 

SAP homepage at http://www.epa.gov/ 

scipoly/sap. 

The FIFRA SAP will prepare meeting 

minutes summarizing its 

recommendations to the Agency 

approximately 90 days after the 

meeting. The meeting minutes will be 

posted on the FIFRA SAP web site or 

may be obtained from the OPP 

Regulatory Public Docket at http:// 

www.regulations.gov. 

List of Subjects 

Environmental protection, Pesticides 

and pests. 


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Dated: May 10, 2007. 

Clifford J. Gabriel, 

Director, Office of Science Coordination and 

Policy. 

[FR Doc. E7–9426 Filed 5–15–07; 8:45 am] 

BILLING CODE 6560–50–S 

ENVIRONMENTAL PROTECTION 

AGENCY 

[FRL–8315–4] 

Science Advisory Board Staff Office 

Notification of Two Public 

Teleconferences of the Science 

Advisory Board Committee on Valuing 

the Protection of Ecological Systems 

and Services 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Notice. 

SUMMARY: The EPA Science Advisory 

Board (SAB) Staff Office announces two 

public teleconferences of the SAB 

Committee on Valuing the Protection of 

Ecological Systems and Services (C–

VPESS) to discuss components of a draft 

report related to valuing the protection 

of ecological systems and services. 

DATES: The SAB will conduct two 

public teleconferences on June 12, 2007 

and June 13, 2007. Each teleconference 

will begin at 12:30 p.m. and end at 2:30 

p.m. (eastern daylight time). 

FOR FURTHER INFORMATION CONTACT: Any 

member of the public wishing to obtain 

general information concerning this 

public teleconference may contact Dr. 

Angela Nugent, Designated Federal 

Officer (DFO), via telephone at: (202) 

343–9981 or e-mail at: 

nugent.angela@epa.gov. General 

information concerning the EPA Science 

Advisory Board can be found on the 

EPA Web site at: http://www.epa.gov/ 

sab. 

SUPPLEMENTARY INFORMATION: The SAB 

was established by 42 U.S.C. 4365 to 

provide independent scientific and 

technical advice, consultation, and 

recommendations to the EPA 

Administrator on the technical basis for 

Agency positions and regulations. The 

SAB is a Federal advisory committee 

chartered under the Federal Advisory 

Committee Act (FACA), as amended, 5 

U.S.C., App. The SAB will comply with 

the provisions of FACA and all 

appropriate SAB Staff Office procedural 

policies. 

Background: Background on the SAB 

C–VPESS and its charge was provided 

in 68 FR 11082 (March 7, 2003). The 

purpose of the teleconference is for the 

SAB C–VPESS to discuss components of 

a draft advisory report calling for 

expanded and integrated approach for 

valuing the protection of ecological 

systems and services. These activities 

are related to the Committee’s overall 

charge: To assess Agency needs and the 

state of the art and science of valuing 

protection of ecological systems and 

services and to identify key areas for 

improving knowledge, methodologies, 

practice, and research. 

Availability of Meeting Materials: 

Agendas and materials in support of the 

teleconferences will be placed on the 

SAB Web site at: http://www.epa.gov/ 

sab/ in advance of each teleconference. 

Procedures for Providing Public Input: 

Interested members of the public may 

submit relevant written or oral 

information for the SAB to consider 

during the public teleconference and/or 

meeting. Oral Statements: In general, 

individuals or groups requesting an oral 

presentation at a public SAB 

teleconference will be limited to three 

minutes per speaker, with no more than 

a total of one-half hour for all speakers. 

To be placed on the public speaker list, 

interested parties should contact Dr. 

Angela Nugent, DFO, in writing 

(preferably via e-mail) 5 business days 

in advance of each teleconference. 

Written Statements: Written statements 

should be received in the SAB Staff 

Office 5 business days in advance of 

each teleconference above so that the 

information may be made available to 

the SAB for their consideration prior to 

each teleconference. Written statements 

should be supplied to the DFO in the 

following formats: One hard copy with 

original signature, and one electronic 

copy via e-mail (acceptable file format: 

Adobe Acrobat PDF, WordPerfect, MS 

Word, MS PowerPoint, or Rich Text 

files in IBM–PC/Windows 98/2000/XP 

format). 

Accessibility: For information on 

access or services for individuals with 

disabilities, please contact Dr. Angela 

Nugent at (202) 343–9981 or 

nugent.angela@epa.gov. To request 

accommodation of a disability, please 

contact Dr. Nugent preferably at least 

ten days prior to the teleconference, to 

give EPA as much time as possible to 

process your request. 

Dated: May 9, 2007. 

Anthony Maciorowski, 

Deputy Director, EPA Science Advisory Board 

Staff Office. 

[FR Doc. E7–9406 Filed 5–15–07; 8:45 am] 

BILLING CODE 6560–50–P 

ENVIRONMENTAL PROTECTION 

AGENCY 

[EPA–HQ–OPP–2006–0909; FRL–8128–9] 

Diazinon; Notice of Receipt of Request 

to Voluntarily Cancel Diazinon 

Pesticide Registrations 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Notice. 

SUMMARY: In accordance with section 

6(f)(1) of the Federal Insecticide, 

Fungicide, and Rodenticide Act 

(FIFRA), as amended, EPA is issuing a 

notice of receipt of a request by the 

registrant to voluntarily cancel the 

registration of its sole product 

containing the pesticide diazinon. The 

request would terminate granular 

diazinon use in or on lettuce. The 

request would also terminate the last 

granular diazinon product registered for 

use in the United States. EPA intends to 

grant this request at the close of the 

comment period for this announcement 

unless the Agency receives substantive 

comments within the comment period 

that would merit its further review of 

the request, or unless the registrant 

withdraws its request within this 

period. Upon acceptance of this request, 

any sale, distribution, or use of products 

listed in this notice will be permitted 

only if such sale, distribution, or use is 

consistent with the terms as described 

in the final order. 

DATES: Comments must be received on 

or before June 15, 2007. 

ADDRESSES: Submit your comments, 

identified by docket identification (ID) 

number EPA–HQ–OPP–2006–0909, by 

one of the following methods: 

• Federal eRulemaking Portal: http:// 

www.regulations.gov. Follow the on-line 

instructions for submitting comments. 

• Mail: Office of Pesticide Programs 

(OPP) Regulatory Public Docket (7502P), 

Environmental Protection Agency, 1200 

Pennsylvania Ave., NW., Washington, 

DC 20460-0001. 

• Delivery: OPP Regulatory Public 

Docket (7502P), Environmental 

Protection Agency, Rm. S-4400, One 

Potomac Yard (South Bldg.), 2777 S. 

Crystal Dr., Arlington, VA. Deliveries 

are only accepted during the Docket’s 

normal hours of operation (8:30 a.m. to 

4 p.m., Monday through Friday, 

excluding legal holidays). Special 

arrangements should be made for 

deliveries of boxed information. The 

Docket telephone number is (703) 305- 

5805. 

Instructions: Direct your comments to 

docket ID number [EPA–HQ–OPP–

2006–0909]. EPA’s policy is that all 


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