### Federal Register / Vol. 48, No. 241 / Wednesday, December 14, 1983 / Notices

ENVIRONMENTAL PROTECTION
AGENCY [OPTS-41013 TSH-FRL #2484-7]

Thirteenth Report ofthe Interagency Testing Committee tothe Administrator, Receipt of Report and Request forComments Regarding PriorityUst ofChemicals
AGENCY: Environmental Protcction Agency (EPA). ACTION: Notice.
SUMMARY: The Interagency Testing Committee (ITC), established under secton 4(e) ofthe Toxic Substances Control Act (TSCA), transmitted its Thirteenth Report to the Administrator ofEPAon November 8, 1983. This report, which revises and updates the Committee's priority list of chemicals, adds four designated chemicals to the list for priority consideration by EPA in the promulgation oftest rules under section 4(a) ofthe Act. Thenew chemicals are 2-(2-butoxyethoxy)ethyl acetate, ethylene bis(oxyethylene) diacetate, 1,2,3,4,7,7- hexachloronorbornadiene, and oleylamine. The Thirteenth Report is included in this notice. The Agency invites interested persons to submit written comments on the Report, and to attend Focus Meetings to help narrow and focus the issues raised by the ITC's recommendations. Members ofthe public are also invited to inform EPA if they wish to be notified of subsequent public meetings on these chemcials. EPA also notes the removal of19 chemicals from the priority list because EPA has responded to the ITC's prior recommendations for testing ofthe chemicals. DATESWritten comments should be submitted by January 13, 1984. Focus Meetings will be held on January 16 and 17, 1984. ADDRESSES: Send written submissions to: TSCA Public Information Office (TS793), Office ofPesticides and Toxic Substances, Environmental Protection Agency, Rm. E-108, 401 M St., SW., Washington, D.C. 20460. Submissions should bear the document control number (OPTS-41012).

The public record supporting this action, including comments, is available forpublic inspection in Rm. E-107 at the address noted above from8:00 a.m. to 4:00p.m. Monday through Friday, except legal holidays. Focus Meetings will be held'at Waterside Mall, in Rm. 3908, 401 M St., SW., Washington, D.C. Persons planning to attend any one of the Focus Meetings and/or seeking to be informed ofsubsequent public meetings on these chemicals, should notify the TSCA Assistance Office at the address listed below. To insure seating accommodiations at the Focus Meeting, persons interested in attending are asked to notify EPA at least 2 weeks ahead ofthe scheduled dates.
FOR FURTHER INFORMATION CONTACT. Jack P. McCarthy, Director, TSCA Assistance Office (TS-799), Office of Toxic Substances, Environmental Protection Agency, 401 M St., SW., Washington, D.C. 20460,Toll Free: (800- 424-9065), In Washington, D.C.: (554- 1404), Outside the USA: (Operator-202- 554-1404).
SUPPLEMENTARY INFORMATION.
I.Background

Section 4(a) ofTSCA (Pub. L. 94-469, 90 Stat. 2003 etseq.; 15 U.S.C. 2601 et seq.) authorizes the Administrator of EPA to promulgate regulations requiring testing ofchemical substances and mixtures in order to develop data relevant to determining the risks that such chemical substances andmixtures may present to health and the environment.

Section 4(e) ofTSCA established an Interagency Testing Committee to make recommendations to the Administrator ofEPA ofchemical substances and mixtures to be given priority consideration in proposing test rules under section 4(a). Section 4(e) directs the Committee to revise its list of recommendations at least every 6 months as it determines to be necessary. The ITCmay "designate" up to 50 substances and mixtures at any one time forpriority consideration by the Agency. For such designations, the Agency must within 12 months either initiate rulemaking or issue in the Federal Register its reasons for not requiring testing. The ITC's Thirteenth Report was received by the Administrator on November 8, 1983, and follows thisNotice. The report designates four substances for priority consideration and response by EPA within 12 months.
II. Written and Oral Comments and Public Meetings

EPA invites interested persons to submit detailed comments on the ITC's

new recommendations. The Agency is interested in receiving information concerning additional or ongoing health and safety studies on the subject chemicals as well as information relating tothe human and environmental exposure to these chemicals. A notice is published elsewhere in today's Federal Register adding the four substances designated in the ITC's Thirteenth Report to the TSCA section 8(d) Health and Safety Data Reporting Rule (40 CFR Part 716). The section 8(d) rule requires the reporting ofunpublished health and safety studies on the listed chemicals. These four chemicals will also be added to the TSCA section 8(a) Preliminary Assessment Information Rule (40CFR Part 712) published elsewhere in this issue. The section 8(a) rule requires the reporting ofproduction volume, use, exposure, and release information on the listed chemicals.

Focus Meetings will be held to discuss relevant issues pertaining to the chemicals and to narrow the range of issues/effects which will be the focus of theAgency's subsequent activities in responding to the ITC recommendations. TheFocus Meetings will be held January 16 and 17, 1984, at Waterside Mall, 401 M St., SW., Washington, D.C., Rm. S355. These meetings are intended to supplement and expand upon written comments submitted inresponse to this notice. The schedule for the Focus Meetings is as follows: January 16, 9:30 a.m.-ethylene bis(oxyethylene) diacetate, and 1:00p.m.-2-(2- butoxyethoxy)ethyl acetate: and January 17, 9:30 a.m.-1,2,3,4,7,7- hexachloronorbornadiene, and 1:00 p.m.-oleylamine. Persons wishing to attend one or more ofthese meetings should call the TSCA Assistance Office at the toll free number listed above at least 2weeks in advance.

After consideration ofthe data pertaining to each chemical, and any additional information provided in the written comments and the Focus Meetings, EPA will hold public meetings

on each chemical afterpreliminary decisions have been made on the types of testing that are needed. These meetings will be several months in the future, but separate notice ofthese meetings will not be published at that time. Therefore, anyone wishing to attend these later meetings should contact EPAnow at the address given for the TSCA Assistance Office in order to be notified in advance ofthe public meetings.

All written submissions should bear the identifying docket number (OPTS41012).
III. Status of List

In addition to adding the 4 designations to the priority list, the ITC's Thirteenth Report notes the removal of8 chemicals from the list since the last ITC report because EPA has responded to the Committee's prior recommendations for testing of the chemicals. Subsequent to the ITC's preparation of itsThirteenth Report, 

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### Federal Register / Vol. 48, No. 241 / Wednesday, December 14, 1983 / Notices

EPAresponded to the ITC's recommendations for 11 additional chemicals. The 19 chemicals removed and the dates ofpublication in the Federal Register ofEPA's responses to the ITCfor these chemicals are: Biphenyl, May 23, 1933 (48 FR 23030); cresols, July 11, 1983 (48FR 31812); ethyltoluene (mixedisomers), May 23, 1983 (4823088); formamide, May 23, 1983 (48 FR 23098); mesityl oxide, July 5,1983 (48 FR 30699); 4,4'-methylenedit niline, July 11, 1983 (46 FR 3180b); and 1,2,4- trimethylbenzene, May 23, 1983 (48FR 2,3088); other trimethylbenzene isomers, May 23, 1983 (48 FR 23088); seven alkyltin compounds, November 8, 1983 (48 FR 51361); bis[2-ethylhexyl) terephthalate, November 14, 1983 (48FR 51845]; 1,3-dioxolane, November 14, 1983 (48 FR 51839]; 4-(1,1,3,3- tetramethylbutyl)pbenol, November 15, 1983 (48 FR 51971); and tris{2- ethylhexyl)trimellitate, November 14, 1983 (48 FR 51842). The current list contains 20 designated substances or groups ofsubstances and one recommended group ofsubstances. (Sec.4,Pub. L94-469, 90 Stat.203; (15 U.S.C. 2601))

Dated: November 25, 1983. Doin R.Clay, ActingAssistant Administrator forPesticides andToxicSubstances. Thirteenth Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency Summary

Section 4 ofthe Toxic Substances Control Act of1976 (TSCA,Pub. L. 94- 469) provides for the testing of chemicals in commerce that may present
an unreasonable risk ofinjury to health

or the environment. It also provides for the establishment ofa Committee, composed ofrepresentatives from eight designated Federal agencies, to recommend chemical substances and mixtures (chemicals) to which the Administrator ofthe U.S. Environmental Protection Agency (EPA) should give priority consideration for the promulgation oftestingrules. Section 4(e)(1)(A) ofTSCA directs the Committee to recommend to the EPA Administrator chemicals to which the Administrator should give priority consideration for the promulgation of testing rules pursuant to section 4(a). The Committee is required to designate those chemicals, from among its recommendations, to which the Administrator shouldrespond within 12 months by either initiating a rulemaking proceeding under section 4(a) or publishing the Administrator's reason for not initiating such a proceeding. Every 6months, the Committee makes those revisions in the TSCA section 4(e) Priority List that it determines to be necessary and transmits them to the EPAAdministrator.

As a result ofits deliberations, the Committee is revising the TSCA section 4(e) Priority List by the addition of4 chemicals and is noting the removal of8,

as a result ofresponses by EPA.

The Priority List is divided into two parts: part A contains those recommended chemicals andgroups designated forpriority consideration and response by the EPA Administrator within 12 months, and part B contains chemicals and groups that have been recommended forpriority consideration by EPA without being designated for response within 12 months. Although TSCA does not establish a deadline for EPAresponse to nondesignated chemicals and groups (partB ofthe Priority List), the Committee anticipates that the EPA Administrator will respond in a timely manner.

The entries being added to the Priority List are presented, together with the types oftesting recommended, in the following Table 1:

Chemical/Group Recommended studies

A Designated for response

within 12 months:

2-(2.Brtoxyethoxy)ethyf Health Effects: Subchonic

acetate (GAS No. toxicity; toxicokinetc stud124-17-4). les; reproductive effects. Ethylene bis(oxyethylene) Health Effects: Subchronic

diacetate (CAS No. 111- toxicity; toxicollnetic stud21-7). Wes; reproductive effects. 1, 2. 3, 4. 7, 7-Hexach- Health Effects: Subchronlc

toronorbornadiene tests, including neurotoxs- (CAS No. 3389-71-7). city; biochemical effects. including enzyme-Inducing capabilities. Oleylamina (GAS No. Health Effects: Toicokntic

112-09-3). studies; Genotoxicity and tsratogenicity studies it percutaneous absorption Is demonstrated. B. Recommended but not

designated for response within 12 months:

None

...................................

TSCA Interagency Testing Committee StatutoryMemberAgenciesandTheir Representatives
Council on Environmental Quality

Thomas H. Magness; III, Member(l) Department ofCommerce

Bernard Greifer, Member Environmental Protection Agency

Carl R. Morris, Member Arthur M. Stem, Alternate National Cancer Institute

Elizabeth K. Weisburger, Member and

Chairperson Richard Adamson, Alternate Jerrold Ward, Alternate National Institute ofEnvironmental Health Sciences Dorothy Canter,Member National Institute For Occupational Safety and Health Rodger L. Tatken, Member Richard J.Lewis, Sr., Alternate National Science Foundation

Winston C. Nottingham, Member and

Vice Chairperson Occupational Safety and Health Administration Ralph Yodaiken, Member(2)
LiaisonAgencies andTheir Representatives
Consumer Product Safety Commission

Arthur Gregory Lakshmi Mishra Department ofAgriculture

Homer E.Fairchild Richard M. Parry, Jr.(3} Department ofDefense

Arthur H.McCreesh Department ofthe Interior

Vyto A. Adomaitis(4) David R. Rosenberger(5) Food and Drug Administration

Winston deMonsabert(6} Arnold Borsetti(7) Allen H.Heim National Toxicology Program

Dorothy Canter
CommitteeStaff
Martin Greif,Executive Secretary Norma Williams, ITCCoordinator SupportStaff
Alan Carpien-Office ofthe General

Counsel, EPA Stephen Ells-Office ofToxic

Substances, EPA Vera W. Hudson-National Library of

Medicine
Notes

(1)

Mr. Magness was appointed onJuly 27, 1983.

(2)Dr.Yodaiken was appointed on July 11. 1983.

(3)Dr.Parry was appointed on September 9,1983.

(4)Mr.Adomaitis was appointed on May 10, 1983.

(5)Mr.Rosenberger was appointed on May 10, 1983.

(6)Dr. deMonsabert retired from Federal Service onAugust 18, 1983.

(7) Dr. Borsetti was appointed on August 16,1983.

The Committee acknowledges and is grateful for the assistance and support given to itby the staffs ofCRCS, Inc., and Dynamac Corporation (technical support prime and subcontractors) and personnel of the EPA Office ofToxic Substances. II I |I I I I 

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### Federal Register / Vol. 48, No. 241 / Wednesday, December 14, 1983 / Notices

Chapter 1-Introduction

1.1 Background.The TSCA Interagency Testing Committee (Committee) was established under section 4(e) ofthe Toxic Substances Control Act of 1976 (TSCA,Pub. L. 94- 469). The specific mandate ofthe Committee is to recommend to the Administrator ofthe U.S. Environmental Protection Agency (EPA) chemical substances and mixtures in commerce that should be given priority consideration for the promulgation of testing rules to determine theirpotential hazard to human health and/or the environment. TSCA specifies that the Committee's recommendations shall be in the form ofa Priority List, which is to be published in the Federal Register. The Committee is directed by section 4(e)(1)(A) ofTSCA to designate those chemicals on the Priority List to which the EPA Administrator should respond within 12 months by either initiating a rulemaking proceeding under section 4(a) orpublishing the Administrator's

reasons for not initiating such a proceeding.

Every 6 months, the Committee makes those revisions in the section 4(e) Priority List thatit determines to be necessary and transmits them to the EPA Administrator.

The Committee iscomprised of representatives from eight statutory member agencies, five liaison agencies, and one national program. The specific representatives and their affiliations are named in the front ofthis report. The Committee's chemical review procedures and priorrecommendations

are described in previouis reports (Refs. I through 12).

1.2 Committee'spreviousreports. Twelve previous reports to the EPA Administrator have been issued by the Committee and published in theFederal Register (Refs. Ithrough 12). Sixty-nine entries (chemicals andgroups of chemicals) were recommended for priority consideration by the EPA Administrator and designated for response within 12 months. In addition, two groups were recommended without being so designated. Removal ofthirtyfive entries was noted in the previous reports. 1.3 Committee'sactivitiesduringthis reporting period.Between April 1, 1983 and September 30, 1983 the Committee continued to review chemicals from its third and fourth scoring exercises (see Ref. 1 for methodology). During this period, the Committee also completed the fifth round ofscoring chemicals, and selected 82 additional chemicals for indepth review.

The Committee contacted 87 chemical manufacturers and trade associations to request information that would be of value in its deliberations. Seventy-one ofthose contacted privided unpublished infoiYnation on current production, expesure, uses, and effects of chemicals under study by the Committee.

During this reporting period, the Committee evaluated 36 chemicals for priority consideration. Four chemicals

were added to the section 4(e) Priority List, and 11 were deferred at this time. The remaining 21 chemicals are still under study.

1.4 The TSCA section4(e)Priority List.Section 4(e)(1)(B) ofTSCA directs the Committee to: "* * make such revisions in the [priority] list as it determines to be necessary and * * * transmit them to the Administrator together with the Committee's reasons forthe revisions." Under this authority, the Committee is revising the Priority List by adding four chemicals: 2-(2-butoxyethoxy)ethyl acetate; ethylene bis (oxyethylene) diacetate; 1,2,3,4,7,7- hexachloronorbornadiene; and oleylamine.All four chemicals are designated forresponse within twelve months. The testing recommended for these chemicals and the rationales for the recommendations are presented in Chapter 2of thisreport.

Eight chemicals and groups of chemicals are being removed from the PriorityList because the EPA Administrator has responded to the Committee's prior recommendations for testingthese chemicals.

They are: biphenyl; cresols; ethyltoluene; formamide, mesityl oxide; 4,4"-methylenedianiline; 1,2,4- trimethylbenzene; and trimethylbenzenes.

With the 4 recommendations and 8 removals noted inthis report, 32 entries now appear on the section 4(e) Priority List. The Priority List is divided in the following Table 2into two parts; namely, Table 2A Chemicals and Groups ofChemicals Designated for Response Within 12 Months, and Table 2B, Other Recommended Chemicals and Groups.

TABLE 2.-THE TSCA SECTION 4(E) PRIORITY LIST NOVEMBER 1983
2A. Chemicals endGroups of Chemicals Designated for Response Within 12 Months

Date of

Enty designation

1.Alkyl epox:des

........................................... Oct. 1T977. 2.Ani;lnrand bromo- chloro- and/or ni- Apr. 1979. troanitines. 3. Aryl phosphates

. ... ...... Apr. 1978. 4.Sis (2-ethylhexyl)terephthalate

.............. Nov. 1982. 5.2-(2-Butoxyethoxy) ethylacetate

.... Nov. 1983. 6. Calcium naphthenate

.............................. May 1983. 7. Chlornated benzenes, mono- and dl-

. Oct. 1977. 8. Chloinated benzenes, hi-, tetra-, and Oct. 1978. penta-. 9. Cobalt naphth enate

............................... May 1983. 10. Cyclohxanone

..................... . Apr. 1979. 11. Dibutyltin bis(isOoctylmaleate)

........... Nov. 1982. 12. D;butyltin bls(isoocty mercaptpece- Do.

tate). 13. Dibutyltin bis(lauryl mercaptlde)

......... Do. 14. Dibutyttin dilaurate

.................................. Do. 15. 1,2.Dichtorowopane

........................... Oct. 1978. 18. Dimethyltin bis(tsooctyl mercaptoace- Nov. 1982.

ste). 17. 1,3-Dioxohne

............. . ...... Nov. 1982. 18. Ethylene bls(oxyethylene)diacetate

. Nov. 1983. 19. Glycidol and its derivatives

..................... Oct. 1978. 20. Halogenated alkyl epoxides

................... Apr. 1978. 21. 1,2,3,4,7,7-Hexachloronorbomadiene

.... Nov. 1983. 22. Hydroquinone

......................................... Nov. 1979. 23. Lead naphthenate

............................... May 1983. 24. Methylolurea

....................................... Do. 25. Monobutyltin tris (laooctyl mercaptoa- Nov. 1982.

cetae). 26. Monomethytin hris (sooctyl mercap- Do.

toacetate). 27. Oleylamlne

.......... ...................... Nov. 1983. 28. 2-Phenoxyethanol._......................... May 1983. 29. Oulnone

............................................... Nov. 1979. 30. 4-(1,13,3_Ttramethybuty phenol

. Nov. 1982. 31.Tris(2-etlyhexy) tDnellitate............ Do.

2B.Other Recommended Chomlcals and Groups of Chemicals

Entry Date of recommendaio

1. Carboluran Internmdiates

................Nov. 1982.

To date,43 chemicals and groups and groups ofchemicals have been removed from the Priority List.The cumulative listis presented in the following Table 3.

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References

(1) Initial Report to the Administrator, Environmental Protection Agency, TSCA Interagency Testing Committee, October 1. 1977. Published in the Federal Registerof Wednesday, October 12, 1977, 42 FR 55026- 55080. Corrections published in the Federal Register ofNovember 11, 1977,42 FR 58777- 58778. The report and supporting dossiers

were also published by the Environmental Protection Agency, EPA 560-10-78/001, January 1978.

(2) Second Report ofthe TSCA Interagency Testing Committee to the Administrator. Environmental Protection Agency. TSCA Interagency Testing Committee, April 1978. Published in the Federal Registerof Wednesday, April 19, 1978,43 FR 16684- 16688. Thereport and supporting dossiers

were also published by the Environmental Protection Agency,EPA 560-10-78/002, July 1978.

(3) Third Report oftheTSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, October 1978. Published in the Federal Register of Monday, October 10, 1978, 43 FR 50630-50635. The report and supporting dossiers were also published by theEnvironmental Protection Agency, EPA560-10-79/001, January 1979.

(4) Fourth Report ofthe TSCA Interagency Testing Committee to theAdministrator, Environmental Protection Agency. TSCA Interagency Testing Committee, April 1979. Published in the Federal Register ofFriday, June 1,1979, 44 FR31866-31889.

(5] Fifth Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, November 1979. Published in theFederal Register of Friday, December 7, 1979, 44 FR 70664-70674.

(6) Sixth Report of theTSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, April 1980. Published in the Federal Register of Wednesday, May 28, 1980,45 FR 35897-35910.

(7) Seventh Report oftheTSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, October 1980. Published in the Federal Register ofTuesday, November 25, 1980, 45 FR 78432-78446.

(8) Eighth Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, April 1981. Published in the Federal Register ofFriday, May 22, 1981, 46 FR 28138-28144.

(9) Ninth Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, October 1981. Published in the Federal Registerof Friday, February 5,1982,47 FR 5456-5403.

(10) Tenth Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, April 1982. Published in the Federal Register ofTuesday, May 25, 1982, 47FR 22585-22596.

(11) Eleventh Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, October 1982. Published in the Federal Register ofFriday, December 3, 1982, 47 FR 54625-54644.

(12)Twelfth Report ofthe TSCA Interagency Testing Committee to the Administrator, Environmental Protection Agency. TSCA Interagency Testing Committee, May 1983. Published in the Federal Register ofWednesday, June 1, 1983, 48 FR 24443-24452. Chapter 2-Recommendations of the Committee

2.1 Chemicalsrecommended for priorityconsideration by theEPA Administrator. As provided by section 4{e)(1)(B) ofTSCA, the Committee is adding the following four chemical substances to the section 4(e) Priority List: 2-(2-butoxyethoxy)ethyl acetate; ethylene bis(oxyethylene) diacetate; 1,2,3,4,7,7-hexachloronorbornadiene; and oleylaniine. The recommendation of these chemicals is being made after considering the factors identified in section 4(e)[1)(A) and other available relevant information, as well as the professional judgment ofCommittee members.

The fourrecommendations designated forre~ponse by the EPA Administrator within 12 months and supporting rationales are presented in section 2.2 of this report.

2.2 Chemicalsdesignated for responsewithin 12months with supporting rationales.
2.2.a Alkyloxyethylene Acetates

Summaryofrecommendedstudies.It is recommended that ethylene bis(oxyethylene) diacetate and 2-(2-- butoxyethoxy)ethyl acetate be tested for the following:

Health Effects: Subchronic toxicity Toxicokinetic studies Reproductive effects Physical and Chemical Information

Ethylene bis(oxyethylene) diacetate and 2-(2-butoxyethoxy)ethyl acetate react vigorouly with oxidizing materials (Refs. 3 and 4, Eastman Kodak Co., 1978, 1981). Available physical and chemical information on the two compounds is given in the following Table 4.

TABLE 4.-PHYSICAL AND CHEMICAL PROPERTIES OF THE ALKYLOXYETHYLENE ACETATES

Propery Ethylene bis(oxyethylene) dlacetateI 2-(2-Butoxyethoxy) ethyl aete b

CAS Number

. .......................... ........................................ 111-21-7

................................................................................................ 1 124-17-4, Synonyms

.. . ...... Tethyle glyco l diacetate; TGD;

.............. ............ ......... Dioethyleneglycol monobutyl ether acetate; DGfA Ethanol. 2Z-[1.2-eanedylbt.oxy)Ibs-. diacetate (CA Index Ethanol. 2-(2-b4toxJethox)-. acetate (CAIndex name).

name). Structural Formula...........-.. . ..................... C> 0-CHIHIoh<CCcHJ.-E-CH'CHlO)1-C\CH

Empirical Formula

....................... C,%H,O

...................................................... ............. .. J,,O. Molecular Wigh

............................................................... 234

............................... ............................ 204. Melting Point

.................................................... .......... Not found

............................................. ............. ........ ...... -32' C. Boiling Point

...... ......................................................... 29......

. ............................... .. .......................... 235' C. Vapor Pressure

.................................................................. Not applicable (nonvolatile)

............................ ................................ 0,04 mniHg at20' C. Specific Gravity

....................... . .......................................... 1.123 at 15.6/15.86 C

......................................................................... 0.980 at 20/20' C. Solubility InWater

.............................................................. Negligible

.... .......................... ................................... . . . . 65 g/L at 20" C. Log Octanol/Water Partition Coeffiient

.......................... -0.1

................................................................................................... 2.01 Description of Chemical

.................... . . Clear iquld; essenally odorless

....................................................... Colorless liquid;fant pleasant odor.

Eastman Kodak Co. 1981(unless otherwise noted). 5Eastman Kodak Co.. 1978. cEstimated (Ref. 10. Lyman at aL.,1982).

Rationale for Recommendations

I.Exposureinformation-A. Production anduse.Thepublic portion ofthe TSCA Inventory (Ref.7, EPA, 1982) lists the 1977 U.S. production of TGD as I million to 10 million pounds and that DGBA as 0.1 million to I millionpounds. These figures were reported as representing current 

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production (Ref. 5,Eastman Kodak Co., 1982).

TGD is used primarily as a plasticizer in bonding cellulose acetate in the manufacture ofcigarette filter tips. DGBA is used primarily as a solvent in printing inks and in high-bake enamel coatings.It is also used as a coalescing aidin latex paints and as a selective solvent in industrial separations (Refs.3 and 5,Eastman Kodak Co., 1978, 1982).

B.Evidenceforexposure.According to a 1972-74 NIOSH survey, the estimated number ofworkers exposed to TGD and DGBA are 152 and 21,461, respectively (Ref. 12,NIOSH. 1982). Approximately 50workers were potentially exposed to TGD and DGBA during manufacturing for 50 and 80 hours annually per worker, respectively (Ref. 5,Eastman Kodak Co., 1982). Consumers may be exposed repeatedly to TGD eluted from cigarette filter tips during smoking (Ref. 6,Eastman Kodak Co., 1983). The possibility of exposure to DGBA when using latex paints also exists.

II. Chemical fateinformation-No data were found; however, based upon their chemical structures both TGD and DGBA are expected tobiodegrade readily in the environment. Neither chemical is expected to persist.

Ill. Biologicaleffects ofconcernto humanhealth-A.Aetabolism.No information was found. However, by analogy with other acetate esters the compounds may undergo enzymatic hydrolysis to the free alcohols (Ref.13, Sandmeyer andKirwin, 1081). The hydrolysis product ofTGD would likely be triethylene glycol, onwhich a metabolism study has been performed (Ref. 11, McKennis et al., 1962). The hydrolysis product ofDGBA is more likely to bethe monobutyl ether of diethylene glycol, orbutyl carbitol. Oxidation ofthe hydrolysis products to alkyloxy acetic acids may also occur (Ref.11, McKennis et al., 1962). These types ofmetabolites may also have testicular effects comparable to those of the glycol ethers (Ref. 8, Foster et al., 1983).

B. Effects on enzymes andother biochemical systems. No information

was found.

C. Carcinogenicity andmutagenicity. No information was found.

D. Short-termacuteeffects. Application of500 mg ofTGD to the skin ofrabbits caused mild irritation; in guinea pigs, TGD also caused slight skin irritation but no sensitization. Application ofTGD to the eyes of rabbits led to slight irritation (Ref. 5, Eastman Kodak Co., 1982). When 500mg ofDGBA was applied to the skin and eyes ofrabbits, irritation was reported. Additional acute toxicity information

on the alkyloxyethylene acetates is summarized in the following Table 5.

Table 5 Acute toxicity of the alkyloxyethylene acetates in laboratory animals.

Animal Route Doe Reference

Triethylene qlycol diacetate (MrD)

Mouse Oral LD5 0 : > 3.2 q/kg Ref. 5

Rat Oral LDh0. 15.5 q/kq Ref. 5

Rat Ihl LT0) 5 > 6.1 mq/L. Ref. 5 6 hours

Guinea piq Skin LDs: > 20 ml/kq Ref. 5 M22.46 /kq)
Diethylene qlyol monobutyl ether acetate MDGBA)

Mouse Oral LD50: 6.6 mAl/kq Ref. 1 (6.5 qfkq)

Rat Oral LD50.7.1 al/kq Ref. 1 (7.0 q/kq)

Rat Oral LD50' 11.9 g/kqa Ref. 14

Rat Ihl Concentrated vapor of unspecified concentration, Ref. 3 for 8 hoursb

Guinea piq Oral LD5 0 : 7.7 ml/kq Ref. 1 (2.6 qkq)

Guinea Piq Oral LDh0:2.3 q/kqa Ref. 14

Rabbit Oral L0 5 0 2.6 ml/kq Ref. 2 (2.5 q/kq)

Rabbit Oral L50:2.8 ml/kq Ref. 2

Rabbit Skin L 5 0 : 5.8 ml/kq Ref. 2 (5.7 q/kq)

Rabbit Skin LDSO: 5.5 ml/kq Ref. 1

Rabbit Skin t;D 5 0 : 14.8 ml/kq (14.5 q/kq) Ref. 3

aDissolved in 1%Tergitol ®

. bone of six animals died.

E.Long-term (subchronic/chronic) effects.Rats fed diets containing 0.1 and I percent TGD for 90 days showed no changes from controls in food intake, weight gain, hematology, urine analysis, gross pathology, or clinical signs (Ref. 5, Eastman Kodak Co.,1982). Likewise, an inhalation study ofrats exposed to TGD
at 0.163 mg/L for 6hours daily for 22 exposures over 29 days showed no changes or lesions indicative ofa toxic response. No information was found on the chronic effects ofthe compound. For DGBA, the 90-day cutaneous [.Dzo inrabbits was on the order of2-3 ml/kg. Skin application led to hematuria, hernolysis inthe kidneys, and renal tublar degenerative changes (Refs. 2 and 1,Draize et al., 1944, 1948). No information was found on the chronic effects ofthe compound.

F. Teratogenicity/embryotoxicity/ fetotoxicityandreproductiveeffects. No information was found. However, the hydrolysis product ofDGBA, namely the monobutyl ether of diethylene glycol, had no appreciable effect on maternal 

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mortality or litter size in mice. An analog, the monobutyl ether ofethylend glycol, had a slight testicular effect in mice (Ref. 9, Hardin, 1983).

G. Rationale forhealtheffects recommendations.Both TGD and DGBA have a relatively low toxicity, but DGBA may be absorbed through the skin, as shown by the appearance ofhematuria, renal tubular changes, and ether effects. The extent ofenzymic hydrolysis of DGBA is now known; moreover, the first hydrolysis product would probably be a glycol ether, a product ofconcern because of the effects ofcertain ofthese compounds on the male reproductive system. Since both worker exposure and poscible consumer exposure are involved, the toxicokinetics and biochemical disposition, as well as the reproductive effects, should be investigated. Additional subchronic toxicity studies in other species are needed to investigate the possible adverse effects on the renal system.

IV.Exologicaleffects-No ecological effects testing is recommended because neither TGD norDGBA is expected to be acutely toxic to aquatic organisms and because neither is expected to persist in the enviroment.
References

(1)Draize JH, AlvarezE,Whitesell MF, Woodard G,Hagan EC, NelsonAA. 1948. Toxicological investigations ofcompounds proposed foruse as insectrepellents. 

### I. Pharmacol. Exp. Ther.98:26-39.

(2)Draize JH, Woodard G, Calvery HO. 1944.Methods for the study ofirritation and toxicity ofsubstances applied topically to the skin and mucous membranes. 1.Pharmacol. Exp.Ther. 82:377-390.

(3)Eastman Kodak Co. 1978.Material Safety Data Sheet andProduct Bulletin (Publication No.M-149B) on diethylene glycol monobutyl ether acetate.

(4)Eastman Kodak Co. 1981. Material Safety Date Sheet on triethylene glycol diacetate.

(5)Eastman Kodak Co. 1982. Unpublished information on triethylene glycol monobutyl ether acetate submitted to ITC by G.Y. Brokaw, Eastman Kodak Co. July13,1982.

(61 Eastman Kodak Co. 1983. Unpublished information on potential consumer expousre to TGD submitted to ITCby G.Ford, Eastman Kodak Co. May 18,1983.

(7)EPA. 1982. Environmental Protection Agency. TSCA Chemical Substances Inventory (public portion). Washington,D.C.: Environmental Protection Agency.

(8)FosterPMD, Creasy DM, FosterJR, Thomas LV,CookMW, Gangolli SD. 1983. Testicular toxicity ofethylene glycol monomethyl and monethyl ethers inthe rat. Toxicol. Appl. Pharmacol. 69:385-399.

(9) HardinBD. 1983.Reproductive toxicity ofthe glycol ethers.Toxicol. 27:91-102. (10) Lyman WJ, Reehl WF,Rosenblatt DH. 1982.Handbook ofChemical Property Estimation Methods. New York: McGraw-Hill Book Co., Chapters 1 adn 7.

(11) McKennis HJr., Turner RA,Turnbull LB,Bowman ER, Muelder WW,Neidhardt MP, Hake CL.Henderson R,Nadev FIG. Spencer S. 1962.The excretion and metabolism of triethyleneglycol. Toxicol. Appl. Pharmacol. 4:411-431.

(12) NIOSH. 1982.National Institute for Occupational Safety and Health.National Occupational Exposure Survey. Cincinnati: National Institute for Occupational Safety and Health.

(13) SandmeyerEE, Kirwin CJ Jr. 1981. Esters.In: Clayton GD, Clayton FE,eds. Patty's Industrial Hyglen andToxicology, 3rd

rev.ed. Vol. 2A:2259-2412.

(14) Smyth HFJr., Seaton J,Fischer L.1941. The single dose toxicityof some glycols and derivatives. J.Ind.Hyg. Toxicol.23:259-268. 2.2.b 1,2,3,4,7,7- Hexachloronorbornadiene

Summary ofrecommendedstudies.It is recommended that 1,2,3,4,7,7- hexachloronorbornadiene be tested for the following:

Health Effects: Subchronic tests, including

neurotoxicity Biochemical effects, including

enzyme-inducing capabilities Physical and Chemical Information

CAS Number: 3389-71-7. Synonyms: Hexachloronorbornadiene; HEX-BCH; Hexachlorobicycloheptadiene; Bicyclo[2.2.1]hepta-2. 5-diene, 1,2,3,4,7,7- hexachloro- (CA Index name) Structural Formula: 

# C1 I CI

Empirical Formula: C1H2CI Molecular Weight: 299 Boiling Point: 118-120 °C at 0.1 mmHg Vapor Pressure: 10-s mmHg at 25 ° C (estimated; Ref. 6, Lyman et al., 1982).

Solubility inWater: 15 mb/L at 250 C (estimated; Ref. 6, Lyman etal., 1982).

Solubility in Organic Solvents: Soluble inether, ethanol, carbon tetrachloride, chloroform,DMSO.

Log Octanol/Water Partition Coefficient: 5.28 (estimated; Ref. 9, Veith etal., 1979).

Description of Chemical: Oily liquid. 

### Rationale for Recommendations

I.Exposureinformation-A. Productionanduse. Hexachloronorbornadiene is an intermediate in the manufacture ofthe pesticide endrin (Ref.10, Velsicol, 1982). In recentyears endrin has been produced in the U.S. in oneplant only, which is inMemphis, Tennessee (Ref.8, SRI, 1982).Based onthe 1981 production volume ofendrin of2million to 4 million pounds (Ref.5, Glaze, 1982),it can be inferred that the production volume of hexachloronorbornadiene in 1981 was 1.5 million to 3million pounds. However, theonly manufacturer ofthe compound has reported thatproduction

was halted in 1982 (Ref.11, Velsicol, 1983a).



### B.Evidenceforexposure. Hexachloronorbornadiene has been 

### released to the environment through waste discharges from theMemphis, Tennessee manufacturing plant. Aqueous wastes havebeen treated by theMemphis municipal sewage treatment plant, then dumped into the Cypress Creek, which emptiesinto the Mississippi River.The compound has been identified inthe air withinthe treatment facility (Ref.3,Elia et al., 1980], in theurine of the treatment plant workers, in the effluent of thetreatment plant (Ref.10, Velsicol, 1982), inthe waters and sediment of the Mississippi River and tributaries (Ref.1,Barthel et al., 1966), and inedible portions offish caught in theMississippi River(Ref. 14, Yurawecz and Roach, 1978). Solid wastes containing hexachloronorbornadiene mostrecently have beenincinerated orburled in

secure landfills (Ref. 10, Velsicol, 1982). 

### but froip 1964 to1972 they were disposed ofin surface landfills. The compound has been found in well water in thevicinity ofthese landfills (Ref.2, Clark et al., 1981).

Although the manufacturer reports no currentproduction, the compound is persistent, and leaching into surface and ground waters from waste residues of the compound may be expected to continue. Human exposure can occur as
a result ofdrinking water oreating fish contaminated with the compound. Residues of the compound and its derivatives found inMississippi River fishare listed in the followingTable 6.

BILLING CODE 6S6--50-l 

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