**Exhibit 31.1**

**Certificationof CEO Pursuant to**

**SecuritiesExchange Act Rules 13a-14(a) and 15d-14(a)**

**as Adopted Pursuantto**

**Section 302of the Sarbanes-Oxley Act of 2002**

I, Avtar Dhillon, President and Chief ExecutiveOfficer of Inovio Biomedical Corporation, certify that:

1.                 I have reviewedthis Annual Report on Form 10-K for the year ended December 31,2005 of Inovio Biomedical Corporation;

2.                 Based on myknowledge, this report does not contain any untrue statement of a material factor omit to state a material fact necessary to make the statements made, inlight of the circumstances under which such statements were made, notmisleading with respect to the period covered by this report;

3.                 Based on myknowledge, the financial statements, and other financial information includedin this annual report, fairly present in all material respects the financialcondition, results of operations and cash flows of the registrant as of, andfor, the periods presented in this report;

4.                 The registrant’sother certifying officer and I are responsible for establishing and maintainingdisclosure controls and procedures (as defined in Exchange Act Rules 13a-14and 15d-14) for the registrant and we have:

a.                 Designed suchdisclosure controls and procedures, or caused such disclosure controls andprocedures to be designed under our supervision, to ensure that materialinformation relating to the registrant, including its consolidatedsubsidiaries, is made known to us by others within those entities, particularlyduring the period in which this report is being prepared;

b.                Designed suchinternal controls over financial reporting, or caused such internal controlsover financial reporting to be designed under our supervision, to providereasonable assurance regarding the reliability of financial reporting and thepreparation of financial statements in accordance with U.S. generally acceptedaccounting principles;

c.                 Evaluated theeffectiveness of the registrant’s disclosure controls and procedures andpresented in this report our conclusions about the effectiveness of thedisclosure controls and procedures, as of the end of the period covered by thisreport based on such evaluation; and

d.                Disclosed in thisreport any change in the registrant’s internal control over financial reportingthat occurred during the registrant’s most recent fiscal quarter (theregistrant’s fourth fiscal quarter in the case of an annual report) that hasmaterially affected or is reasonably likely to materially affect, theregistrant’s internal control over financial reporting; and

5.                 The registrant’sother certifying officer and I have disclosed, based on our most recentevaluation, to the registrant’s auditors and the audit committee of theregistrant’s board of directors (or persons performing the equivalent functions):

a.                 All significantdeficiencies and material weaknesses in the design or operation of internalcontrol over financial reporting which are reasonably likely to adverselyaffect the registrant’s ability to record, process, summarize and report financialinformation; and

b.                Anyfraud, whether or not material, that involves management or other employees whohave a significant role in the registrant’s internal controls over financialreporting.

| **Date: March 16, 2006** | **   /s/  Avtar Dhillon**                       |
|-------------------------------|-----------------------------------------------------------|
| ** **                    | **Avtar  Dhillon  President and Chief Executive Officer** |

 

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