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                                                                   EXHIBIT 10.40


                                PROMISSORY NOTE
                                ---------------


$250,000.00


1.   Promise to Pay.
     --------------

     For value received, I, Fabrizio Bonanni ("Staff Member"), a married man,
     and I, Lorraine Bonanni, wife of Staff Member, promise to pay to the order
     of Amgen Inc., a Delaware corporation ("Payee"), at its office at Amgen
     Center, Thousand Oaks, CA 91320-1789, the sum of Two Hundred Fifty Thousand
     Dollars and No Cents ($250,000.00) (the "Principal"). Amgen will forgive
     twenty percent (20%) of the loan principle on each anniversary date of
     Staff Member's employment until the loan principle is paid in full. Each
     year the principle amount is reduced by twenty percent (20%), the interest
     only payments will be reduced accordingly. The loan amount that is forgiven
     each year will be reported as income to Staff Member and will be subject to
     federal, state, and other applicable taxes. If Staff Member ceases to be an
     employee of Payee, this Note shall become payable in full thirty (30) days
     from the date on which Staff Member ceases to be an employee of Payee,
     together with interest on the Principal from the date of this Note until
     such date as the Note is paid in full. Interest on this Note shall be
     computed as set forth below. The interest rate for the period from the date
     of this Note through December 31, 1999 (the "initial rate") is 4.4% per
     annum on the unpaid Principal. After December 31, 1999 the interest rate on
     this Note shall change as set forth below.

2.   Adjustable Interest Rate.
     ------------------------

     The interest rate shall be adjusted annually on January 1 of each year (the
     "Change Date") so as to equal the average interest rate designated as the
     "Introduction Rates" on adjustable rate loans as publicly offered by the
     banks and savings and loans in California as published by the Los Angeles
     Times in its Sunday edition. The rate shall be set using the rates
     published in the Los Angeles Times on the Sunday immediately preceding the
     Change Date. In the event that the "Introduction Rates" list is not
     published in the Los Angeles Times for any reason, then, in such event, the
     Payee shall establish the interest rate based on a survey by it of the
     introductory interest rates on adjustable loans offered by no fewer than
     five banking institutions located in Southern California that the Payee, in
     its sole discretion, deems representative of banking institutions in the
     Ventura and Los Angeles County areas. Payee shall give Staff Member notice
     if the interest rate shall be determined using this alternative method.
     Notwithstanding the foregoing, the interest rate shall never be increased
     or decreased on any single Change Date by more than one percentage point
     from the interest rate for the preceding 12 months. At no time during the
     term of this Note shall the annual interest rate exceed 7.4% per annum.

     Payee shall deliver or mail to Staff Member a notice of any changes in the
     adjustable interest rate on this Note and the amount of the Staff Member's
     semi-monthly payroll deductions before the effective date of any change.
     The notice shall include information required by law to be given to Staff
     Member and also the title and telephone number of a person who shall answer
     any questions Staff Member may have regarding the notice.

3.   Salary Deduction.
     ----------------

     The interest on this Note shall be payable by semi-monthly deductions from
     Staff Member's salary.  The amount of such deductions shall initially be
     Four Hundred Fifty-Eight Dollars and Thirty-Three Cents ($458.33) per
     installment; provided, however, that the manner of payment of this Note
     shall not be limited to deductions from Staff Member's salary.  The amount
     of such deductions shall be adjusted annually concurrently with any
     adjustment in the interest rate on this Note to ensure that interest to be
     incurred during the ensuing
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     calendar year shall be paid in twenty-four (24) equal payments. The first
     such installment shall be on August 31, 1999; the second installment shall
     be on September, 15, 1999; and each successive installment shall be on the
     fifteenth and last days of each successive month until the Principal is
     repaid. Payee shall give Staff Member at least seven (7) days advance
     notice of any adjustment in the amount of said payroll deductions. Staff
     Member acknowledges and agrees that by executing this Note, Staff Member
     agrees to the payroll deductions described in this Note.

4.   Prepayment.
     ----------

     Staff Member may prepay without penalty this Note in whole or in part at
     any time. Any and all payments or prepayments under this Note may be made
     by Staff Member to Payee at the following address (or such other address as
     it designates in writing to Staff Member):

                    AMGEN INC.
                    Amgen Center
                    Thousand Oaks, California 91320-1789

                    Attention:  Accounting Manager

5.   Attorneys' Fees.
     ---------------

     Staff Member agrees to pay all costs and expenses, including, without
     limitation, collection agency fees and expenses, reasonable attorneys'
     fees, costs of suit and costs of appeal, which Payee may incur in the
     exercise, preservation or enforcement of its right, powers and remedies
     hereunder, or under any documents or instruments securing this Note, or
     under law.

6.   Modification of Terms.
     ---------------------

     Payee may, with or without notice to Staff Member, cause additional parties
     to be added to this Note, or release any party to this Note, or revise,
     extend, or renew the Note, or extend the time for making any installment
     provided for by this Note, or accept any installment in advance, all
     without affecting the liability of Staff Member. Staff Member may not
     assign or transfer in any manner whatsoever this Note or any of Staff
     Member's obligations under this Note.

7.   Security Interest.
     -----------------

     The purpose of this loan is to purchase a personal residence.  Staff Member
     shall secure this loan by executing and causing to be filed, immediately
     upon close of escrow, a trust deed on this residence, commonly known as 343
     South Beverly Glen, Los Angeles, CA  90024 whose property description is as
     follows:

          Lot 22 in Block 3 of Tract No. 7733, in the City of Los Angeles,
          County of Los Angeles, State of California, as per Map recorded in
          Book 130, Pages 28, 29 and 30 of Maps, in the Office of the County
          Recorder of said County.

8.   Acceleration.
     ------------

     A) In the event Staff Member fails to pay when due any sums under this
     Note, then:

          (1)  the entire unpaid balance of this Note shall, at the option of
          the Payee hereof, immediately become due and payable in full and
          unpaid Principal thereafter shall bear

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          interest at the lesser of the maximum rate permitted by law or at the
          rate of 7.4% per annum; and

          (2)  Staff Member authorizes Payee to deduct any sums due to Payee
          under this Note from any monies, including any wages due, otherwise
          owing to Staff Member.

     B)   If Staff Member sells the residence which is purchased with the funds
     herein provided, this Note shall immediately become due and payable upon
     the sale of such residence.

9.   Waiver of Rights by Staff Member.
     --------------------------------

     Staff Member waives (1) presentment, demand, protest, notice of dishonor
     and/or protest and notice of non-payment; (2) the right, if any, to the
     benefit of, or to direct the application of, any security hypothecated to
     Payee until all indebtedness of Staff Member to Payee, however arising, has
     been paid; and (3) the right to require the Payee to proceed against any
     party to this Note, or to pursue any other remedy in Payee's power.  Payee
     may proceed against Staff Member directly and independently of any other
     party to this Note, and the cessation of the liability of any other party
     for any reason other than full payment, or any revision, renewal,
     extension, forbearance, change of rate of interest, or acceptance, release
     or substitution of security, or any impairment or suspension of Payee's
     remedies or rights against any other party, shall not in any way affect the
     liability of Staff Member.

10.  Obligations of Persons Under this Note.
     --------------------------------------

     If more than one person signs this Note, each person is fully and
     personally obligated to keep all of the promises made in this Note,
     including the promise to pay the full amount owed. Any person who is a
     guarantor, surety, or endorser of this Note is also obligated to do these
     things. Any person who takes over these obligations, including the
     obligations of a guarantor, surety or endorser of this Note, is also
     obligated to keep all of the promises made in this Note. Payee may enforce
     its rights under this Note against each person individually or against all
     of the signatories to this Note. This means that any one of the signatories
     to this Note may be required to pay all of the amounts owed under this
     Note.

11.  Governing Law.
     -------------

     This Note and the obligations under this Note of Staff Member or any other
     signatory to this Note shall be governed by and interpreted and determined
     in accordance with the laws of the State of California as applied to
     contracts between California residents entered into and to be performed
     entirely within said State.

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IN WITNESS WHEREOF, the undersigned has/have executed and delivered this Note as
of the 7th day of August, 1999.



                                            /s/ Fabrizio Bonanni
                                            --------------------
                                            FABRIZIO BONANNI



                                            /s/ Lorraine Bonanni
                                            --------------------
                                            LORRAINE BONANNI

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