**Exhibit 10.5**

**EMPLOYMENT AGREEMENT**

This Employment Agreement (the“Agreement”), dated as of December 27, 2010 is made by and between Inovio Pharmaceuticals, Inc., a Delaware corporation having offices at 1787 Sentry Parkway West, Bldg 18, Suite 400, Blue Bell PA 19422 (the“Company”), and Peter Kies, having residence at 3657 Tierra De Dios, Escondido, California 92025 (“Executive”). 

**R E C I T A L S**

**WHEREAS**, the Company desires to employ Executiveand to have the benefit of his skills and services, and Executive desires to accept employment with the Company, on the terms and conditions set forth herein; and 

**WHEREAS**, as a condition to his employment by the Company, Executive agrees to execute and shall be bound by the terms and conditions of the Proprietary Information, Invention, and Non-CompeteAgreement (the “Non-Compete Agreement”) attached hereto as Exhibit A, and the Confidentiality and Non-Disclosure Agreement (the “Confidentiality Agreement”), attached hereto as Exhibit B. 

**NOW, THEREFORE**, in consideration of the mutual promises, terms, covenants and conditions set forth herein and in the Non-CompeteAgreement, and the performance of each, the parties hereto, intending legally to be bound, hereby agree as follows: 

 

a. TheCompany hereby agrees to employ Executive as Chief Financial Officer, and Executive hereby agrees to accept such employment with the Company in accordance with the terms and conditions of this Agreement. 

b. The “Term” of this Agreement shall commence on the date hereof (the “Commencement Date”) and shallcontinue in effect until terminated as provided in Section 7 below. 

 

a.The Company agrees to employ Executive throughout the Term as Chief Financial Officer of the Company with such responsibilities, duties and authority as are assigned to him by the Chief Executive Officer of the Company or his designee. 

b. Executive shall faithfully devote his full business/working time, attention and energy to the business and affairs of the Company andthe performance of his duties hereunder and to use reasonable efforts to perform such responsibilities faithfully and efficiently. 

c. Without limiting the generality of the foregoing paragraph, during the Term, upon prior written consent of the Chief Executive Officer of the Company, Executive shall be permitted to serve on otherBoards of Directors, professional associations and otherwise be involved with any family business or trust to the extent that, in the reasonable judgment of the Chief Executive Officer, such other business pursuits and activity do not materially(i) interfere 

with Executive’s ability to discharge Executive’s duties and responsibilities to the Company, whether or not such activity is pursued for gain, profit or other pecuniary advantage, or(ii) cause Executive to violate any provision of the Non-Compete Agreement or the Confidentiality Agreement. 

 
3.Compensation. 
a.Executive shall be entitled to receive as compensation for his employment a base annual salary at a rate of $230,000 per annum (the “Base Salary”), which shall be paid to Executive by the Company or any of its affiliates inaccordance with the Company’s standard payroll practices, as in effect from time to time. 

b. Increases in the BaseSalary shall be reviewed annually by the Company’s Board of Directors (the “Board”) or its Compensation Committee during the Term, and any such increases will be at the Board’s or Compensation Committee’s solediscretion and will otherwise be consistent with the Company’s annual policies and budget for payroll increases. 

 
4.Bonus. 
During the Term,Executive shall be eligible to receive an incentive cash bonus up to the amount, based upon the criteria, and payable at such times, as may be determined by the Board or its Compensation Committee. The amount shall be determined by the Board orCompensation Committee, in its sole and absolute discretion, which shall be binding and final, and shall be paid in a one-time lump sum payment (less payroll taxes). To the extent that such cash bonus is to be determined in light of financialperformance during a specified fiscal period and the Agreement commences on a date after the start of such fiscal period, any cash bonus payable in respect of such fiscal period’s results may be prorated. In addition, if the period ofExecutive’s employment hereunder expires before the end of a fiscal period, and if Executive is eligible to receive a cash bonus at such time (such eligibility being subject to the restrictions set forth in Section 7 below), any cash bonuspayable in respect of such fiscal period’s results may be prorated. Notwithstanding the foregoing, all annual bonuses shall be paid within two and one-half months after the close of each year. 

 
5.Benefits; Stock Options. 
In addition to the salary and cash bonus referred to above, Executive shall be entitled during the Term to participate in such employeebenefits plans or programs of the Company, and shall be entitled to such other fringe benefits, as are from time to time adopted by the Board and made available by the Company generally to employees of Executive’s position, tenure, salary, andother qualifications. Without limiting the generality of the foregoing, Executive shall be eligible for such awards and benefits, if any, under the Company’s employee benefits plans or programs as shall be granted to Executive in the solediscretion of the Board or its Compensation Committee and as shall be provided pursuant to the terms of the plans or programs. Executive acknowledges and agrees that the Company does not guarantee the adoption or continuance of any particularemployee benefits plan or program or other fringe benefits during the Term, and participation by Executive in any such plan or program shall be subject to the rules and regulations applicable thereto. 

 
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6.Expenses. 
The Companywill reimburse Executive, in accordance with the practices in effect from time to time for other officers or staff personnel of the Company, for all reasonable and necessary business and traveling expenses and other disbursements incurred byExecutive for or on behalf of the Company in the performance of Executive’s duties hereunder, upon presentation by Executive to the Company of appropriate vouchers and supporting documentation. 

 
7.Termination. 
Executive’s employment by the Company pursuant hereto is subject to termination as follows: 

a. Death or Disability. Executive’s employment shall be deemed to terminate automatically on the date of Executive’sdeath, and the Company may by written notice to Executive terminate Executive’s employment on account of his Total Disability effective as of the date of such notice. For purposes hereof, Executive shall be deemed to experience a “TotalDisability” if Executive is considered totally disabled under any group disability plan maintained by the Company and in effect at that time, or in the absence of any such plan, Executive shall be deemed to experience a Total Disability ifhe shall have been unable to perform his duties hereunder on a full-time basis for 90 consecutive days or longer, or for shorter periods aggregating 120 days in any 360-day period. In the event of any dispute under this Section 7(a), Executiveshall submit to a physical examination by a licensed physician mutually satisfactory to the Company and Executive, the cost of such examination to be paid by the Company, and the determination of such physician shall be determinative. In the case ofa Total Disability, until the Company shall have terminated Executive’s employment hereunder in accordance with the foregoing, Executive shall be entitled to receive compensation provided for herein notwithstanding any such Total Disability. Inthe event of the termination of Executive’s employment on account of his death or Total Disability, neither Executive nor his personal representative will have any rights or claims against the Company under this Agreement except as follows:

(i) Executive (or his estate or representative, as applicable) shall be paid (A) any unpaid portion of his Base Salarycomputed on a pro rata basis through the date of his termination and (B) any unreimbursed expenses; 

(ii) All other ofExecutive’s accrued but unpaid rights shall be as determined under any incentive compensation, stock option, retirement, employee welfare or other employee benefits plan or program of the Company in which Executive is then participating at thetime of his termination; and 

(iii) in the case of Executive’s Total Disability only, (A) the Company shall continueExecutive’s medical benefits coverage existing at the time of his termination for as long as permissible under the Company’s health benefits policies (not to exceed 60 days) and the Company further agrees to pay Executive’s COBRApremiums for six months thereafter, with such premiums to provide for coverage at the same level and subject to the same terms and conditions (including, without limitation, any applicable co-pay obligations of Executive, but

 
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excluding any applicable tax consequences for Executive) as in effect for Executive at the time of termination, and (B) Executive shall further receive a lump-sum payment, within 30 daysafter the effective date of termination, equal to the aggregate amount of Executive’s Base Salary as in effect immediately prior to such termination that would be payable over a period of six months following the effective date of suchtermination. 

b. Involuntary Termination for Cause. In the event the Company terminates Executive’s employment forCause (as such term is defined below), such termination shall be effective immediately upon notice thereof, in which case Executive will have no rights or claims against the Company under this Agreement except as follows: 

(i) Executive shall be paid (A) any unpaid portion of his Base Salary computed on a pro rata basis through the date of histermination and (B) any unreimbursed expenses; and 

(ii) All other of Executive’s accrued but unpaid rights shall beas determined under any incentive compensation, stock option, retirement, employee welfare or other employee benefits plan and program of the Company in which Executive is then participating at the time of his termination. 

“Cause” shall mean: (1) conviction of Executive of any felony; (2) participation by Executive in any fraud oract of dishonesty against the Company; (3) material violation by Executive of (i) any contract between the Company and Executive, or (ii) any statutory, contractual or common law duty of Executive to the Company; (4) conduct ofExecutive that, based upon a good faith and reasonable factual investigation and determination by the Board, demonstrates Executive’s gross unfitness to serve; or (5) the continued, willful refusal or failure by Executive to perform anymaterial duties reasonably requested by the Board or the Chief Executive Officer. 

c. Involuntary Termination WithoutCause. The Company may terminate Executive’s employment, other than on account of death, Total Disability or for Cause, on 30 days’ prior written notice, in which case Executive will have no rights or claims against the Company underthis Agreement except as follows: 

(i) Executive (or his estate or representative, as applicable) shall be paid (A) anyunpaid portion of his Base Salary computed on a pro rata basis through the date of his termination, and (B) any unreimbursed expenses; 

(ii) All other of Executive’s accrued but unpaid rights shall be as determined under any incentive compensation, stock option, retirement, employee welfare or other employee benefits plan and programof the Company in which Executive is then participating at the time of his termination; 

(iii) Executive shall receiveseverance payments in the form of monthly payments of Executive’s Base Salary (as in effect immediately prior to such termination) for a period of twelve months following the effective date of such termination; and 

 
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(iv) The Company shall pay Executive’s COBRA premiums for twelve months thereafter,with such premiums to provide for coverage at substantially the same level and subject to the same terms and conditions (including, without limitation, any applicable co-pay obligations of Executive, but excluding any applicable tax consequences forExecutive) as in effect for Executive at the time of termination. 

d. Voluntary Termination For Good Reason. Executivemay terminate his employment for good reason (“Termination For Good Reason”) by providing 30 days’ prior written notice to the Company of a breach constituting Good Reason, which notice shall be provided within 45 days afterthe initial existence of the breach, and further provided that such breach is not cured in all material respects to the reasonable satisfaction of Executive within 30 days after such notice. In the event of Termination for Good Reason, Executiveshall be entitled to receive the payments and other rights provided in Section 7(c) hereof. For purposes of this Agreement, termination for “Good Reason” shall mean voluntary termination by Executive of his employment withthe Company based on one of the following events: 

(i) the material diminution in Executive’s position, title,responsibilities or authority from those in effect at the Commencement Date; provided, however, that a material diminution shall not be deemed to have occurred upon a change of control of the Company solely by virtue of the Company’s havingbeen acquired and made part of a larger organization; 

(ii) a relocation of Executive’s principal executive offices morethan fifty miles from its location at the Commencement Date; or 

(iii) the breach by the Company of any of its materialobligations under this Agreement; 

e. Other Voluntary Termination. Executive may otherwise terminate his employmentwithout Good Reason upon 30 days’ prior written notice to the Company, in which case Executive (or his estate or representative, as applicable) shall be paid (A) any unpaid portion of his Base Salary on a pro rata basis through the date ofthe termination, and (B) any unreimbursed expenses. 

f. Section 409A. The Base Salary continuation set forthin Sections 7 (a), (c) and (d) hereof shall be intended to satisfy either (i) the safe harbor set forth in the regulations issued under Section 409A (as defined below) of the Internal Revenue Code of 1986, as amended (the“Code”) (Treas. Regs. 1.409A-1(n)(2)(ii)), or (ii) be treated as a Short-term Deferral as that term is defined under Section 409A (Treas. Regs. 1.409A-1(b)(4)). To the extent that such continuation payments exceed the applicablesafe harbor amount or do not constitute a Short-term Deferral, the excess amount shall be treated as deferred compensation under Section 409A and as such shall be payable pursuant to the following schedule: such excess amount shall be paid viastandard payroll in periodic installments in accordance with the Company’s usual practice for its senior executives. 

Notwithstanding any provision in this Agreement to the contrary, in the event that Executive is a “specified employee” asdefined in Section 409A, any continuation payment, continuation benefits or other amounts payable under this Agreement that would be subject to the 

 
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special rule regarding payments to “specified employees” under Section 409A(a)(2)(B) of the Code shall not be paid before the expiration of a period of six months following thedate of Executive’s termination of employment or before the date of Executive’s death, if earlier. 

g. Forfeitureof Rights. In the event that, subsequent to the termination of Executive’s employment hereunder, Executive breaches any of the provisions of the Non-Compete Agreement or Confidentiality Agreement in any material respect, all payments andbenefits to which Executive may otherwise have been entitled to pursuant to this Section 7 hereof shall immediately terminate and be forfeited. 

h. Release. Executive shall not be entitled to any compensation under this Section 7 unless Executive executes and delivers to the Company a Separation of Employment Agreement and GeneralRelease (the “Release”) in form and substance satisfactory to the Company, by which Executive releases the Company from any obligations and liabilities of any type whatsoever, except for the Company’s obligation to provide thecompensation and benefits specified in this Section 7. The parties hereto acknowledge that the payments to be provided under this Section 7 are to be provided in consideration for the Release. 

 
8.Remedies. 
In addition toother remedies provided by law or equity, upon a breach by Executive of any of the covenants contained herein, in the Non-Compete Agreement or in the Confidentiality Agreement, the Company shall be entitled to have a court of competent jurisdictionenter an injunction against Executive enjoining Executive and prohibiting any further breach of the covenants contained herein. Executive acknowledges that a breach or threatened breach by Executive of the provisions of this Agreement will causeirreparable damage to the Company because Executive’s services to be performed hereunder are of a unique, special and extraordinary character. Thus, the Company shall be entitled to injunctive relief without the necessity of proving actualdamages and the Company shall not be required to post a bond or other security in support of such injunctive relief. 

 
9.Arbitration. 
Any claim,dispute or controversy arising out of or in connection with Executive’s employment by the Company, his separation from the Company, this Agreement, or any breach thereof, shall be arbitrated by the parties before a sole neutral arbitrator (whoshall have substantial experience in the pharmaceutical and life sciences industry) conducted in accordance with the National Rules for the Resolution of Employment Disputes of the American Arbitration Association then in effect. The claims subjectto mandatory arbitration under the terms of this agreement include, but are not limited to, claims that have been or could be asserted under: (a) the common law of the State of California; (b) the California Labor Code; (c) Title VIIof the Civil Rights act of 1964, as amended, 42 U.S.C. § 2000e *et seq*.; (d) the California Fair Employment and Housing Act, Cal. Govt. Code § 12900 *et seq*.; (e) the Consolidated Omnibus BudgetReconciliation Act of 1985 (COBRA), as amended, 26 U.S.C. § 4980B; (f) the Age Discrimination in Employment Act of 1967, as amended, 29 U.S.C. § 621 *et seq.*, including the Older Workers Benefit Protection Act;(g) the Employee Retirement Income Security Act of 1974, as amended, 29 U.S.C. § 1001 *et seq*.; (h) the Civil Rights Act of 1866, as amended, 42 

 
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U.S.C. § 1981 *et seq*.; (i) the Fair Labor Standards Act, 29 U.S.C. § 201 *et seq*.; (j) the Americans with Disabilities Act, 42 U.S.C. § 12101*et seq*.; (k) the Civil Rights Act of 1991, Public Law 102-166 (105 Stat. 1071); (l) the Wage Orders of the California Industrial Welfare Commission; (m) any other federal, state or local law, constitution, regulation,ordinance, decision or common law claim concerning employment discrimination or termination of employment; (n) any and all claims for personal injury, emotional distress, libel, slander, defamation, and other physical, economic, or emotionalinjury; and (o) all claims for attorney’s fees and costs. 

The arbitrator shall have the authority to orderdiscovery sufficient for both parties to adequately arbitrate any and all claim(s) and defense(s) at issue. Such discovery shall include access to relevant documents and witnesses but shall not have the authority to add to, detract from or modifyany provision hereof nor to award damages or other remedies not otherwise available under statute(s), contract(s) or common law relevant to the claim(s) and defense(s) at issue. Following the close of all evidence at the conclusion of thearbitration hearing, the neutral arbitrator shall issue a written award that reveals his or her essential findings and conclusions. The neutral arbitrator’s decision shall be final and binding. Judgment may be entered on the arbitrator’saward in any court having jurisdiction. The direct expense of any arbitration proceeding shall be borne by the Company. Each party shall bear its own attorneys’ fees unless such fees are awarded as a measure of damages under the applicablecontract or statute at issue. Such arbitration hearing shall take place in Montgomery County, Pennsylvania at a location and date mutually agreeable to the parties. The parties hereto consent to the jurisdiction of the state and federal courtslocated in the Commonwealth of Pennsylvania with respect to any action arising under this Agreement. Notwithstanding the foregoing, the Company shall be entitled to seek injunctive or other equitable relief, as contemplated by Section 8 hereof,from any court of competent jurisdiction, without the need to resort to arbitration. 

 
10.Assignment; Binding Nature. 
This Agreement shall be binding upon and inure to the benefit of the parties and their respective successors, heirs (in the case of Executive) and permitted assigns. No rights or obligations of theCompany under this Agreement may be assigned or transferred by the Company except that such rights or obligations may be assigned or transferred to the successor of the Company or its business if the assignee or transferee assumes all of theliabilities, obligations and duties of the Company, as contained in this Agreement, either contractually or as a matter of law. If any such successor of the Company or its business does not agree to so assume such liabilities, obligations andduties, Executive may immediately resign, which shall be deemed a Termination For Good Reason under the provisions of this Agreement. No rights or obligations of Executive under this Agreement may be assigned or transferred by Executive other thanExecutive’s rights to compensation and benefits, which may be transferred only by will or operation of law, except as otherwise specifically provided or permitted hereunder. 

 
11.Notice. 
Any notice whicha party is required or may desire to give pursuant to this Agreement shall be given in writing by personal delivery, by facsimile transmission, by registered or 

 
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certified mail, return receipt requested, postage prepaid, or by overnight courier, at the following addresses: 

**If to the Company:**

Inovio Pharmaceuticals, Inc. 

1787 Sentry Parkway West 

Building 18, Suite 400 

Blue Bell, PA 19422 

Attention: Chief Executive Officer 

**If to Executive:**

Peter Kies 

3657 Tierra De Dios 

Escondido, California 92025 

Any notice personally delivered shall be deemedreceived when given, or if given by facsimile or overnight courier shall be deemed received on the next business day and any notice mailed shall be deemed received on the third business day thereafter. 

 
12.Entire Agreement. 
ThisAgreement and the Non-Compete Agreement (Exhibit A) and the Confidentiality Agreement (Exhibit B) constitute the complete agreements and understandings between the Company and Executive concerning Executive’s employment by the Company, andsupersede any and all previous agreements or understandings concerning such employment, whether written or oral, between Executive and the Company. 

 
13.Modification. 
ThisAgreement may not be waived, amended or modified without the express written consent of the party against whom enforcement of such Agreement is sought. 

 
14.Waiver. 
Except as setforth herein, no delay or omission to exercise any right, power or remedy accruing to any party shall impair any such right, power or remedy or shall be construed to be a waiver of or an acquiescence to any breach hereof. No waiver by either partyof any breach by the other party of any condition or provision contained in this Agreement to be performed by such other party shall be deemed a waiver of a similar or dissimilar condition or provision at the same or any prior or subsequent time.Any waiver must be in writing and signed by Executive and the Chief Executive Officer or other duly authorized officer of the Company. 

 
17.Section 409A. 
It isintended that this Agreement be drafted and administered in compliance with section 409A of the Code, including, but not limited to, any future amendments to Code section 409A, 

 
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and any other Internal Revenue Service or other governmental rulings or interpretations (collectively, “Section 409A”) issued pursuant to Section 409A so as not to subjectExecutive to payment of interest or any additional tax under Section 409A. The parties intend for any payments under this Agreement to either satisfy the requirements of Section 409A or to be exempt from the application ofSection 409A, and this Agreement shall be construed and interpreted accordingly. In furtherance thereof, if payment or provision of any amount or benefit hereunder that is subject to Section 409A at the time specified herein would subjectsuch amount or benefit to any additional tax under Section 409A, the payment or provision of such amount or benefit shall be postponed to the earliest commencement date on which the payment or provision of such amount or benefit could be madewithout incurring such additional tax. In addition, to the extent that any Internal Revenue Service guidance issued under Section 409A would result in Executive being subject to the payment of interest or any additional tax underSection 409A, the parties agree, to the extent reasonably possible, to amend this Agreement in order to avoid the imposition of any such interest or additional tax under Section 409A, which amendment shall have the minimum economic effectnecessary to the Executive and shall not result in any additional cost to the Company, unless it agrees otherwise to incur such cost, and shall be reasonably determined in good faith by the Company and Executive. 

 
18.Invalidity of Any Provision. 
If any portion of this Agreement is held invalid or inoperative, the other portions of this Agreement shall be deemed valid and operative and, so far as is reasonable and permitted by the law, effectshall be given to the intent manifested by the portion held invalid or inoperative. 

 
19.Applicable Law. 
ThisAgreement shall be governed by and construed in accordance with the laws of the Commonwealth of Pennsylvania, without regard to the principles of conflict of laws thereof. 

 
20.Counterparts. 
ThisAgreement may be executed simultaneously in any number of counterparts, each of which shall be deemed an original but all of which together shall constitute one and the same agreement. 

 
21.Headings. 
The Sectionheadings contained in this Agreement are for reference purposes only and will not affect in any way the meaning or interpretation of this Agreement. 

 
22.Binding Effect. 
Theprovisions of this Agreement will be binding upon, and will inure to the benefit of, the respective heirs, legal representatives and successors of the parties thereto. 

**[SIGNATURES ON FOLLOWING PAGE]**

 
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IN WITNESS WHEREOF, the parties hereto have executed this Employment Agreement as of thedate first written above. 

 
**INOVIO PHARMACEUTICALS, INC.**By: 
/s/ J. Joseph Kim, Ph.D.
 Name: J. Joseph Kim, Ph.D. Title: President and CEODate: 12/27/10**EXECUTIVE**
/s/ Peter Kies
Name: Peter KiesDate: 12/27/10
 
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