### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF

PESTICIDES AND

TOXIC

SUBSTANCES



## MEMORANDUM

SUBJECT: Section 3 Registration Request for Uses of Zoxamide (Chemical #101702 ,

DP Barcodes: D266174 and D254295)

FROM: Lewis Brown, Biologist

Mark Corbin, Environmental Scientist

James Hetrick, Senior Physical Scientist

Richard Mahler, Chemist

Environmental Risk Branch 1

Environmental Fate and Effects Division (7507C)

THRU: Sid Abel, Acting Branch Chief

Environmen tal Risk Branch 1

Environmental Fate and Effects Division (7507C)

TO: Mary Rust, Biologist

Registration Action Branch 3

Registration Division (7509C)

Cynthia Giles

- Parker, Product Manager

Fungicide Branch

Registration Division (7505C)

Attached is the Environmental Fate and Effects Division (EFED) environmental

risk assess ment for Zoxamide registration

.

## TABLE OF CONTENTS

Page

ENVIRONMENTAL RISK CONCLUSIONS

................................ ................................ ................ 1

Aquatic Organism Risk Conclusions

................................ ................................ ....... 1

Avian Risk Conclusions

................................ ................................ ........................... 1

Mammal Risk Conclusions

................................ ................................ ...................... 1

Environmental Fate Risk Conclusions

................................ ................................ ..... 1

INTRODUCTION

................................ ................................ ................................ ........................... 2

Chemical Identification

................................ ................................ ............................ 2

Mechanism of Action

................................ ................................ ............................... 3

Use Sites

................................ ................................ ................................ ................... 3

Target Pest

................................ ................................ ................................ ............... 3

Formulation Type

................................ ................................ ................................ ..... 3

Rate and Method of Application

................................ ................................ .............. 3

Approach to Risk Assessment

................................ ................................ ................. 4

INTEGRATED ENVIRONMENTAL RISK CHARACTERIZATION

................................ .. 4

ENVIRONMENTAL FATE ASSESSMENT

................................ ................................ .......... 5

SURFACE AND GROUND AND DRINKING WATER ASSESSMENT

............................ 9

AQUATIC EXPOSURE AND RISK ASSESSMENT

................................ ............................ 13

Toxicity to Aquatic Animals

................................ ................................ .................. 13

Aquatic Exposure Assessment

................................ ................................ ............... 14

Aquatic Risk Assessment

................................ ................................ ....................... 14

Risk Assessment: Risk Quotient Calculation for Aquatic Organisms

................... 18

Aquatic Organism Risk Characterization

................................ .............................. 20

TERRESTRIAL ORGANISM EXPOSURE AND RISK ASSESSMENT

......................... 21

Toxicological Profile

................................ ................................ ............................. 21

Terrestrial Exposure

................................ ................................ ............................... 21

Avian Risk

................................ ................................ ................................ . 22

Mammalian Risk

................................ ................................ ........................ 22

Semi

- Aquatic & Terrestrial Plant Exposure & Risk Assessment

.......................... 24

Terrestrial Risk Characterization

................................ ................................ ........... 25

ENDANGERED SPECIES

................................ ................................ ................................ ............ 25

## APPENDIX A

ENVIRONMENTAL FATE DISCUSSIONAND STRUCTURES OF

ZOXAMIDE AND DEGRADATES

................................ ................................ ..... 26

APPENDIX BMODELING D ISCUSSION

................................ ................................ ............. 38

APPENDIX CTOXICITY DATA TABLES

................................ ................................ ........... 95

APPENDIX DGENERALIZED EFED RISK ASSESSMENT METHODAND

CALCULATION TABLES FOR RISK QUOTIENTS

................................ ....... 105

APPENDIX EDATA REQUIREMENTS

................................ ................................ .............. 113

APPENDIX FREFERENCES

................................ ................................ ................................ 117

# Zoxamide

Environmental Fate and Ecological Effects

Assessment and Characterization

for a Section 3 for Aerial and Ground Spray Treatment to

Grapes and Potatoes

## 1 ENVIRONMENTAL RISK CONCLUSIONS

The subject chemical of this risk assessment is a selective, non

- systemic fungicide that has

demonstrated specific protectant properties against oomycete fungi and is identified by the trade

chemical name zoxamide and is referred to in this assessment as zoxamide. The proposed use

si tes are grapes and potatoes. Approximately 1 million acres of grapes and 1.3 million acres of

potatoes were grown in the United States in 2000. Zoxamide initiates severe disruption and

dislodging of the microtubules cytoskeleton in plants, therefore, the xylem and phloem are

decreased in size thus inducing impairment for the normal transport of food and water. The

target pests are downy mildew ( Plasmopara viticola ) on grapes and late blight ( Phytophthora

infestans ) on potatoes. There are 2 formulations , a 80 WP containing 80% zoxamide, and a 75%

DF formulation (a mixture of 8.3% zoxamide and 66.7% mancozeb). Zoxamide can be applied

aerially or with ground equipment. The 80 WP formulation was used for all surface water

assessment inputs due to the high er active ingredient content for this formulation.

Aquatic Organism Risk Conclusions

Risk to aquatic organisms are expected to be low even when the high end use rate for

zoxamide (0.2 lbs ai/A at 8 applications per year) is used despite the high toxici ty. No

levels of concern (LOCs) were exceeded and therefore it is concluded that aquatic

organisms will be at low risk when multiple applications are used. The Agency’s level of

concern for endangered and threatened freshwater fish and estuarine/marine i nvertebrates is

exceeded for the proposed use of zoxamide on grapes. The registrant must provide information

on the proximity of Federally listed freshwater fish and estuarine/marine invertebrates to the

proposed use sites.

Avian Risk Conclusions

Risk t o avian organisms are expected to be low even when the high end use rate for

zoxamide (0.2 lbs ai/A at 8 applications per year) is used. No levels of concern (LOCs)

were exceeded and therefore it is concluded that birds will be at low risk when multipl e

applications are used.

Mammal Risk Conclusions

Risk to mammals are expected to be low even when the high end use rate for zoxamide

(0.2 lbs ai/A at 8 applications per year) is used. No levels of concern (LOCs) were

exceeded and therefore it is conc luded that mammals will be at low risk when multiple

applications are used.

Environmental Fate Risk Conclusions

The major routes of dissipation for zoxamide are hydrolysis, photodegradation in water, and

microbial mediated degradation. Zoxamide may persist in the environment for days to months

and is practically immobile, with a low potential for movement into grou ndwater. The data

## 2 show that hydrolysis, especially at pH 9, is an important degradation process of

zoxamide . The photodegradation half

- life for zoxamide in water was 14 days (corrected for dark

control) in pH 4 buffer solution. Photodegradation of zoxa mide on soil does not appear to be a

major route of dissipation because the half

- lives in irradiated and dark control samples were

similar, 10.2 and 11.7 days, respectively. Because of its high affinity for soil and sediment,

zoxamide has the potential to move off the site of application during rainfall/irrigation by

erosion/runoff on soil particles and by drift. Given the degradation rates for metabolism and soil

photolysis, and the high K

oc 

## values, zoxamide will probably be adsorbed to sediments and orga nic

material if transported to surface waters.

The estimated drinking water concentrations are based on zoxamide residues for all studies used as

input parameters for modeling. Tier II ( PRZM

- EXAMS) surface water modeling for zoxamide

(parent only) using the index reservoir with the percent cropped area (PCA=0.87 for grapes and

potatoes) predicts the 1 in 10 year peak (acute) concentration of zoxamide residues on grapes is

not likely to exceed 16.9 μg/L and on potatoes is not likely to exceed 4.9 μg/L. Th e 1 in 10 year

annual average concentration (non

- cancer chronic) of zoxamide residues on grapes is not likely to

exceed 0.9 μg/L and on potatoes is not likely to exceed 0.2 μg/L. The 36 year annual average

concentration (cancer chronic) of zoxamide residue s on grapes is not likely to exceed 0.5 μg/L and

on potatoes is not likely to exceed 0.2 μg/L.

EFED conducted a Tier II drinking water assessment for zoxamide (RH 117281) and its

transformation products (zoxamide and its identifiable degradation product s including

RH

- 150721, RH

- 24549, RH

- 141288, RH

- 129151, RH

- 139432, RH

- 127450, and RH

- 163353).

Tier II surface water modeling using the index reservoir with the percent cropped area (PCA=0.87

for grapes and potatoes) predicts the 1 in 10 year peak (acute) co ncentration of zoxamide residues

on grapes is not likely to exceed 77.7 μg/L and on potatoes is not likely to exceed 20.9 μg/L. The 1

in 10 year annual average concentration (non

- cancer chronic) of zoxamide residues on grapes is

not likely to exceed 21.8 μ g/L and on potatoes is not likely to exceed 6.2 μg/L. The 36 year annual

average concentration (cancer chronic) of zoxamide residues on grapes is not likely to exceed 12.4

μg/L and on potatoes is not likely to exceed 4.1 μg/L

The SCI

- GROW predicted conce ntration of zoxamide in shallow ground water is not expected to

exceed 0.061 μg/L. The SCI

- GROW predicted concentration of zoxamide residues (zoxamide +

degradation products) in shallow ground water is not expected to exceed 2.07 μg/l.

INTRODUCTION

Chemi cal Identification

The subject chemical of this risk assessment is a selective, non

- systemic fungicide that has

demonstrated specific protectant properties against oomycete fungi and is identified by the trade

chemical name zoxamide and is referred to in this assessment as zoxamide. The chemical

identification number is 101702 . The Chemical Abstract System (CAS) number is 156052

- 68

- 5.

Mechanism of Action

## 3 Zoxamide’s mode of action is produced by the specific binding at selective action sites al ong the

beta subunits of tubulin in plants. Zoxamide initiates severe disruption and dislodging of the

microtubules cytoskeleton in plants, meaning the xylem and phloem are decreased in size thus

inducing impairment for the normal transport of food and water.

Use Sites

The proposed use sites are grapes and potatoes. According to the most recent U.S. Department of

Agriculture National Agricultural Statistics Service report ( http://usda.mannlib.cornell.edu ),

approximately 1 and 1.3 million acres of gra pes (AZ, AR, CA, GA, MI, MO, NY, NC, OH, OR,

PA, SC, and WA) and potatoes (CA, CO, ID, IN, ME, MA, MI, MN, MT, NE, NV, NM, NY, ND,

OH, OR, PA, RI, SD, UT, WA, WI, and WY) were grown in the United States in 2000,

respectively.

Target Pest

The target p ests are downy mildew ( Plasmopara viticola ) on grapes and late blight ( Phytophthora

infestans ) on potatoes.

Formulation Type

The proposed labeled formulations of zoxamide include:

1. Zoxamide 80 WP containing 80% zoxamide,

2. Zoxamide 75% DF formulation (a mixture of 8.3% zoxamide and 66.7% mancozeb)

Rate and Method of Application

Zoxamide can be applied aerially or with ground equipment.

There are 2 formulations, a 80 WP containing 80% zoxamide, and a 75% DF formulation (a

mixture of 8.3% zoxamide and 66.7% mancozeb) for use on grape and potato. For the 80WP, the

label permits multiple foliar applications of zoxamide on grapes and potatoes at 0.125

- 0.2 lb

ai/A/application with a maximum of 8 applications per growing season and a seasonal ma ximum

rate of 1.6 lb ai/A. Pre

- harvest intervals (PHI) of 3 days are proposed on potato and 14 days on

grape.

For the 75% DF formulation (Gavel 75 DF), the label permits 6 foliar applications of zoxamide to

potatoes at 0.12

- 0.17 lb ai/A/applica tion. The maximum seasonal rate is 1 lb ai/A. The PHI for

potato varies from 3 days in the states of CT, DE, FL, ME, MA, MI, NH, NY, OH, PA, RI, VT, and

WI, and at least 14 days elsewhere. For grape, up to 0.21 lb ai/A/application may be applied West

of the Rockies with a maximum of 3 applications and a maximum rate of 0.62 lb ai per season. In

## 4 regions located east of the Rocky Mountains, a maximum of 8 applications per season (1.25 lb

ai/A) is permitted.

Approach to Risk Assessment

EFED’s assessment of risks associated with the use of zoxamide focused on acute and chronic

risks to aquatic organisms and terrestrial wildlife.

For aquatic organisms, EFED conducted modeling of surface water concentrations of the parent

compound as well as the parent plus all degradates (zoxamide and its identifiable degradation

products including RH

- 150721, RH

- 24549, RH

- 141288, RH

- 129151, RH

- 139432, RH

- 127450,

and RH

- 163353). The highest exposure scenario (aerial application to grapes and potatoes) was

used for the m odeling exercise. The aquatic exposure modeling associated with grapes and

potatoes agriculture use sites incorporates assumptions of high surface runoff and erosion, thereby

providing a conservative exposure scenario. Acute lethality as well as effects on reproduction,

growth and survival of offspring were considered in this risk assessment consistent with the

toxicological profile of the parent compound as well as estimated data on degradates.

For terrestrial wildlife, the risk assessment was limited t o consideration of exposure via

consumption of contaminated diet. Exposure estimates were made for birds and mammals.

Acute lethality, reproduction/developmental, and a hemolytic effect specific to mammals were all

considered in the risk assessment, base d on the toxicological profile of the parent compound.

INTEGRATED ENVIRONMENTAL RISK CHARACTERIZATION

Zoxamide may be persistent for days to months and is practically immobile in the environment.

Zoxamide degrades with a half life of 8 to 15 days under hydrolytic conditions. Photolysis is

rapid in water and slow on soil. Because of its high affinity for soil and sediment, zoxamide has

the potential to move off the site of application during rainfall/ irrigation by erosion/runoff on soil

particles and by drift. Given the degradation rates for metabolism and soil photolysis, and the high

K

oc 

## values, zoxamide will probably be adsorbed to sediments and organic material if transported to

surface waters.

Although zoxamide is moderately to very highly toxic to aquatic organisms and zoxamide exhibits

persistence in the field, model predictions of surface water concentrations using a high exposure

application scenario on grapes and potatoes (maximum application rate, minimum application

interval) do not t rigger high concern for acute toxic nor chronic risks. This is likely due to the

combination of low initial mass of pesticide used at each application (0.2 lb a.i./acre) and the low

mobility of parent in terrestrial and aquatic environments.

Eve n though the types of target crops proposed for zoxamide application may put application in

proximity to estuarine/marine environments, concerns for acute effects in estuarine/marine

invertebrates, as suggested by the risk quotient calculations, are not li kely. The PRZM/EXAMS

modeling is an uncertain but likely conservative predictor of concentrations in surface waters of

estuarine systems.

## 5 The Agency’s level of concern for endangered and threatened freshwater fish and estuarine/marine

invertebrates is e xceeded for the proposed use of zoxamide on grapes and potatoes. The

registrant must provide information on the proximity of Federally listed freshwater fish and

estuarine/marine invertebrates to the proposed use sites.

No acute or chronic levels of conc ern for estuarine/marine fish, freshwater invertebrates,

estuarine/marine invertebrates, mammals, or birds were exceeded by any single or multiple

application of zoxamide.

None of the degradates of zoxamide are included in exposure estimates.

ENVIRONMENTAL FATE ASSESSMENT

Appendix A includes detailed descriptions of environmental fate studies for zoxamide.

Physical/Chemical properties : RH

- 117281, RH

- 7281

Chemical Name:

3,5

- dichloro

- N

- (3

- chloro

- 1

- ethyl

- 1

- methyl

- 2

- oxopropyl)

- 4

- methylbenzamide

Molecular formula: C 14 

## H 16 

## Cl 3 

## NO 2 

## Molecular weight: 336.1 g/mole

Physical state: Fine Powder

Melting Point: 159.5

- 161.0 o 

## C

Vapor Pressure: <1 x 10

- 7 

## torr @ 25 **°** C

Henry’s Law Constant: 6 x 10

- 10 

## atm m 3 

## mol

- 1



## Log K

ow 

## : 3.76

Solubility @ 25 0 

## C 0.68 mg/L in water

CAS Number: 156052

- 68

- 5

PC Code: 101702

Structure:

Zoxamide (3,5

- dichloro

- N

- (3

- chloro

- 1

- ethyl

- 1

- methyl

- 2

- oxopropyl)

- 4

- methylbenzamide) is the

proposed common name for the active ingredient for this fungicide. (Please refer to Appendix A

for chemical structures of zoxamide degradates).

## 6 The major routes of degradation for zoxamide are hydrolysis, photodegradation in water, and

microbial mediated degradation. Zoxamide had hydrolysis half

- lives of 15.5 days in pH 4 buffer

solution, 15.7 days in pH 7 buffer solution, and 8.1 days in pH 9 buffer solut ion. The major

hydrolysis degradates were:

RH

- 150721 (benzoic acid, 3,5

- dichloro

- 4

- methyl, 3

- amino

- 3

- methyl

- 2

- oxopentyl ester

, 38% of applied radioactivity),

RH

- 24549 (benzoic acid, 3,5

- dichloro

- 4

- methyl, 31 % of applied radioactivity)

,

RH141288 ( ben zamide,

3,5

- dichloro

- N

- (1

- ethyl

- 3

- hydroxy

- 1

- methyl

- 2

- oxopropyl)

- 4

- methyl) 22 % of

applied radioactivity),

RH

- 129151 ( 4 H

- 1,3

- Oxazin

- 5(6 H )

- one,

2

- (3,5

- dichloro

- 4

- methylphenyl)

- 4

- ethyl

- 4

- methyl , 25 % of applied).

The photodegradation half

- life for zoxamide in water was 14 days (corrected for dark control) in

pH 4 buffer solution. Less than 1% of the applied radioactivity was CO 2 

## . The major aqueous

photolysis degradates were:

RH

- 150721 (benzoic acid, 3,5

- dichloro

- 4

- methyl, 3

- amino

- 3

- methyl

- 2

- oxopentyl es ter

, 11% of applied radioactivity), and

RH

- 24549 (benzoic acid, 3,5

- dichloro

- 4

- methyl, 28 % of applied radioactivity ).

RH

- 139432 ( Benzamide, 3,5

- dichloro

- 4

- methyl , 42 % of applied radioactivity).

Photodegradation of zoxamide on soil does not appear to be a major route of dissipation because

the half

- lives in irradiated and dark control samples were similar, 10.2 and 11.7 days, respectively.

Correcting for the dark control half

- life produced a soil photolysis half

- life of 78 days, also

indicating little soil photodegradation. Furthermore, the pattern of transformation product

formation was very similar in the irradiated samples and the dark controls. It appears that

degradation was primarily hydrolytic and not due to photolytic processes. Less than 1% o f the

applied radioactivity was CO 2 

## , indicating little oxidative mineralization. Soil bound residues

accounted for 32% of the applied radioactivity. The main degradation products were:

RH

- 24549 (benzoic acid, 3,5

- dichloro

- 4

- methyl, 22 % of applied radioactivity ),

RH

- 129151 ( 4 H

- 1,3

- Oxazin

- 5(6 H )

- one,

2

- (3,5

- dichloro

- 4

- methylphenyl)

- 4

- ethyl

- 4

- methyl , 4 % of applied

radioactivity), and

RH

- 127450 (Benzamide, 3,5

- dichloro

- N

- (1

- ethyl

- 1

- methyl

- 2

- oxopropyl)

- 4

- methyl, 11%

of applied radioactivity).

## 7 Zoxamide degraded with half

- lives of 37.5 and 38.1 days in aerobic soil metabolism studies.

Approximately 48% of the applied radioactivity was CO 2 

## at the end of the study. Soil bou nd

residues accounted for 39% of the applied radioactivity. Only minor (<10% of applied

radioactivity) degradation products were formed:

RH

- 24549 (benzoic acid, 3,5

- dichloro

- 4

- methyl, 7 % of applied radioactivity ),

RH

- 127450 (Benzamide, 3,5

- dichloro

- N

- (1

- ethyl

- 1

- methyl

- 2

- oxopropyl)

- 4

- methyl, 6%

of applied radioactivity),

RH

- 129151 ( 4 H

- 1,3

- Oxazin

- 5(6 H )

- one,

2

- (3,5

- dichloro

- 4

- methylphenyl)

- 4

- ethyl

- 4

- methyl , 1.6 % of applied

radioactivity), and

RH

- 139432 ( benzamide, 3,5

- dichloro

- 4

- methyl , 1.0 % of appli ed radioactivity).

In pH 7.9 and 8.1 aerobic aquatic environments (soil + water system), zoxamide degraded with

half

- lives of 3.6 and 7.6 days. Approximately 20% of the applied radioactivity was CO 2 

## at the end

of the study. Sediment bound residues accounted for 37% of the applied radioactivity.

Degradation products identified were:

RH

- 150721 (benzoic acid, 3,5

- dichloro

- 4

- methyl, 3

- amino

- 3

- methyl

- 2

- oxopentyl ester

, 11% of applied radioactivity),

R H

- 127450 (benzamide, 3,5

- dichloro

- N

- (1

- ethyl

- 1

- methyl

- 2

- oxopropyl)

- 4

- methyl, 13

and 20% of applied radioactivity), and

RH

- 163353 (no scientific name was provided for this transformation product, however, it

was identified as the parent compound with a CO OH

- group in place of the

CH 2 

## Cl group by LC/MS, 7 and 13 % of applied radioactivity).

In anaerobic soil metabolism environment, zoxamide degraded with a half

- life of 14.6 days.

Approximately 5% of the applied radioactivity was CO 2 

## at the end of the study . Soil bound

residues accounted for 56% of the applied radioactivity. Degradation products formed were:

RH

- 24549 (benzoic acid, 3,5

- dichloro

- 4

- methyl, 17 % of applied radioactivity ),

RH

- 127450 (benzamide, 3,5

- dichloro

- N

- (1

- ethyl

- 1

- methyl

- 2

- ox opropyl)

- 4

- methyl, 13%

of applied radioactivity),

RH141288 ( benzamide,

3,5

- dichloro

- N

- (1

- ethyl

- 3

- hydroxy

- 1

- methyl

- 2

- oxopropyl)

- 4

- methyl) 0.7 % of

applied radioactivity),

## 8 RH

- 129151 ( 4 H

- 1,3

- Oxazin

- 5(6 H )

- one,

2

- (3,5

- dichloro

- 4

- methylphenyl)

- 4

- ethyl

- 4

- methyl , 0.9 % of applied

radioactivity), and

RH

- 139432 ( benzamide, 3,5

- dichloro

- 4

- methyl , 0.5 % of applied radioactivity).

The results of batch equilibrium studies suggest low mobility of zoxamide in terrestrial and aquatic

environments. Soil:water partition coefficients (K d 

## ) for zoxamide are 3.4, 10.4, 12.4, 15.2 and

25.3 ml/g. There was a significant correlation of soil organic matter content and soil:water

partitioning coefficients. Soil:water partition coefficients normalized to the organic carbon

conte nt of the soil (K

oc 

## ) were 815, 1196, 1294, 1385 and 1431 ml/g. Further studies are required

on aged zoxamide in order to assess the mobility of degradates. It should be noted that several of

the degradates found in the other laboratory studies are benzoi c acid derivatives containing

carboxylic acid functional groups and appear to be stable in the environment; hence, they are

expected to be more mobile that zoxamide.

Zoxamide had fish bioconcentration factors of 12 and 19X for fillets,170 and 256X for viscera, and

95 and 136X for whole fish tissues, respectively. Approximately 70% of bioconcentrated

residues were eliminated over a 21 depuration period. Generally, if the K

ow 

## of a compound is less

than three, then EFED assumes there is little potent ial for accumulation in fish. Since the K

ow 

## zoxamide is 3.76 and up to 30% of the compound was not depurated, there is a moderate potential

for bioaccumulation in fish. Degradates identified in fish tissues were:

RH

- 127450 (Benzamide, 3,5

- dichloro

- N

- ( 1

- ethyl

- 1

- methyl

- 2

- oxopropyl)

- 4

- methyl, 17.2

% of applied radioactivity),

RH

- 141288 ( benzamide,

3,5

- dichloro

- N

- (1

- ethyl

- 3

- hydroxy

- 1

- methyl

- 2

- oxopropyl)

- 4

- methyl), 3.6 %

of applied radioactivity),

RH

- 141288 ( benzamide,

3,5

- dichloro

- N

- (1

- ethyl

- 3

- hydroxy

- 1

- methyl

- 2

- oxopropyl)

- 4

- methyl), 10.1 %

(sulfate) of applied radioactivity).

Zoxamide had terrestrial field dissipation half

- lives of 11.5, 15, and 17.7 days and 9.4, 14.2 and

68.6 days on bare ground plots in California and New York, and Canada, respect ively. The

registrant did not try to identify any of the degradates detected in the laboratory studies in

concentrations > 10 % of applied. All degradates at concentrations > 10% of applied radioactivity

identified in the laboratory studies have to be loo ked for in the field studies.

The field dissipation results are difficult to interpret because of the lack of adequate information on

the frozen storage stability of zoxamide. There were no detection of parent below 15 cm (12

inches). However, because of the problem with storage stability, leaching below that depth is a

possibility. In the storage stability study submitted, the data shows zoxamide is not stable

(recoveries ranged from 113 to 50.8 %) in soil samples stored frozen for up to 373 days

## 9 prior to analysis. Conversely, the field samples that were re

- analyzed showed little

degradation after 676 days of storage, which would indicate that zoxamide is stable when

stored frozen for up to 676 days. Until these issues are resolved (storage stability of

parent and degradates, and identification of degradates in the field studies), the terrestrial

field dissipation studies can not be relied upon to provide reliable information on the

half

- life of zoxamide residues under actual use conditions, nor mobility to groundwater;

therefore, the studies are not acceptable.

SURFACE, GROUND AND DRINKING WATER ASSESSMENT

Because zoxamide is not included among regulated or unregulated chemicals required as analytes

in testing of public drinking water supplies, drinking

- water monitoring results are not available.

Therefore, drinking water exposure assessments are based on modeling predictions. Surface

water concentrations of zoxamide was modeled using both the GENEEC (Tier I) and the

PRZM/EXAMS (Tier II) programs. Groundwater concentrations were modeled using the

SCI

- GROW program. Input parameters used in Tier I (GENEEC version 1.2) and Tier II (PRZM

version 3.12/EXAMS version 2.97.5) modeling were selecting using Agency guidance

(“ Guidance for Chem istry and Management Practice Input Parameters for Use in Modeling the

Environmental Fate and Transport of Pesticides” dated August 6, 2000) and EFED calculated

degradation rate constants from review of registrant submitted environmental fate studies.

The assessment strategy was designed to assess concentrations of the parent compound and

zoxamide residues (zoxamide plus RH

- 150721, RH

- 24549, RH

- 141288, RH

- 129151,

RH

- 139432, RH

- 127450, and RH

- 163353). A cumulative residue approach was employed to

provid e conservative estimated concentrations in drinking water for zoxamide and its degradation

products. This approach was taken because of limited environmental fate data for zoxamide

degradation products. Fate data for the cumulative residue approach were estimated using

published software (Estimation Programs Interface (EPI), Version 3.04, 1999) which estimates

fate parameter using published equations. More detail on EPI estimation techniques may be

found at http://syrres.com/interkow/epi.htm.

Tier I (G ENEEC) modeling estimates that aerially and ground

- applied zoxamide are not expected

to exceed the concentrations listed in Table 1. Additionally, Tier I modeling estimates that

zoxamide residues (zoxamide + degradation products) which are aerially and gr ound

- applied are

not expected to exceed the parent equivalent concentrations listed in Table 2.

Table 1. Estimated Environmental Concentrations ( μ g/L) of Parent Zoxamide in

Surface Water (GENEEC Tier 1 modeling) used for Aquatic Exposure Asses sment.

Application Regime Crop Peak 4 day 21 day 56 day

Multiple Aerial Potatoes 18.4 16.6 9.8 4.7

## 10 Multiple Ground Potatoes 17.6 15.8 9.4 4.5

Multiple Aerial Grapes 16.4 14.8 8.7 4.2

Multiple Ground Grapes 15.8 14.2 8.4 4.0

Table 2. Estimated Environmental Concentrations ( μ g/L) of Total Zoxamide

Residues in Surface Water (GENEEC Tier 1 modeling) used for Aquatic Exposure

Assessment.

Application Regime Crop Peak 4 day 21 day 56 day

Multiple Aerial Potatoes 57.0 56.2 52.1 45.1

Multiple Ground Potatoes 56.3 55.5 51.5 44.5

Multiple Aerial Grapes 61.1 60.3 55.9 48.3

Multiple Ground Grapes 60.4 59.6 55.2 47.8

Tier II ( PRZM

- EXAMS) surface water modeling for zoxamide (parent only) using the aquatic

exposure scenario (standard pond) estimates the concentration of zoxamide residues on grapes is

not likely to exceed the concentrations in Table 3.

Table 3. PRZM

- EXAMS Predicted Zoxamide Concentratio ns in the Aquatic (Pond)

Scenario

Simulation Scenarios Concentration (ug/L)

1 in 10 Year Estimate

Crop and Location Scenario Peak 96 Hour 21 Day 60 Day

Potatoes, Arastook

Co., ME Aquatic(Pond)

Scenario 2.3 1.2 0.6 0.4

Grapes Chautauqua

Co, NY Aquatic (Pond)

Scenario 7.5 4.3 2.1 1.1

Tier II ( PRZM

- EXAMS) surface water modeling for zoxamide (parent only) using the index

reservoir with the percent cropped area (PCA=0.87 for grapes and potatoes) estimates the

concentration of zoxamide residues on grapes is not likely to exceed the concentrations in Table

4.

Table 4. PRZM

- EXAMS Predicted Parent Zoxamide Concentrations in the Index Reservoir

Simulation Scenarios Concentration (μg/L)

## 11 1 in 10 year Mean

of

Annual

Means Crop and

Location Scenario

Peak 96

Hour 21

Day 60

Day 90

Day Annual

Mean

Potatoes,

Arastook

Co., ME Index

Reservoir 5.6 3.4 1.8 1.1 0.8 0.2 0.2

Index

Reservoir

w/PCA (0.87) 4.9 3.0 1.6 1.0 0.7 0.2 0.2

Grapes

Chautauqua

Co, NY Index

Reservoir 19.5 13.4 7.1 3.5 2.7 1.0 0.6

Index

Reservoir

w/PCA (0.87) 16.9 11.7 6.2 3.0 2.3 0.9 0.5



## Tier II ( PRZM

- EXAMS) surface water modeling for zoxamide residues (zoxamide + degradation

products) using the index reservoir with the percent cropped area (PCA=0.87 for grapes and

potatoes) estimates the parent equivalent concentration of zoxamide residues on gra pes is not

likely to exceed the concentrations in Table 5.

Table 5: PRZM

- EXAMS Predicted Total Zoxamide Residue Concentrations in the Index

Reservoir

Simulation Scenarios Concentration (μg/L)

1 in 10 Year Mean

of

## 12 Crop and

Location Scenario Peak 96

Hour 21

Day 60

Day 90

Day Yearly Annual

Values

Potatoes,

Arastook

Co., ME Index

Reservoir 24.0 23.4 22.0 19.4 17.1 7.2 4.7

Index

Reservoir

w/PCA (0.87) 20.9 20.3 19.2 16.9 14.9 6.2 4.1

Grapes

Chautauqua

Co, NY Index

Reservoir 89.3 86.6 80.9 68.5 59.8 25.1 14.3

Index

Reservoir

w/PCA (0.87) 77.7 75.3 70.4 59.6 52.1 21.8 12.4



## The SCI

- GROW predicted concentration of zoxamide in shallow ground water is not expected to

exceed 0.061 μg/L. The SCI

- GROW predicted parent equivalent concentration of zoxamide

residues (zoxamide + degradation products) in shallow ground water is not expe cted to exceed

2.07 μg/l.

Appendix B provides a detailed discussion of the modeling efforts for GENEEC, PRZM/EXAMS,

and SCI

- GROW.

Uncertainties, Assumptions and Limitations

There are several uncertainties and assumptions in the assessment of zoxamide and its degradates.

Primary among these is the lack of environmental fate data for the transformation products of

zoxamide. In order to address this uncertainty, EFED has conducted the Tier II modeling

(PRZM/EXAMS) on the summed zoxamide residu es (zoxamide and its identifiable degradation

products including RH

- 150721, RH

- 24549, RH

- 141288, RH

- 129151, RH

- 139432, RH

- 127450,

and RH

- 163353) instead of individual residues. Although the persistence of the zoxamide

residues was estimated from registra nt submitted environmental fate data, the mobility of

zoxamide residues was estimated using the zoxamide degradate RH

- 24549 (Benzoic acid,

3,5

- dichloro

- 4

- methyl ). This compound was used to assess mobility because it is expected to be a

highly mobile zoxam ide residue in soil and aquatic environments Physical chemistry

parameters were estimated for RH

- 24549 (Estimation Programs Interface (EPI), Version 3.04,

1999) and degradation rate constants were estimated by performing linear regression on the total

r esidues (Sigmaplot 2000 version 6.00

- Regression Wizard) from several fate studies..

The abiotic hydrolysis of zoxamide was assumed to be important degradation mechanism in

aquatic metabolism studies. Therefore, in order to avoid double

- counting hydrolysi s in surface

water modeling, the aquatic metabolism data were not corrected for abiotic hydrolysis and the

hydrolysis half lives were not directly used as input into the model.

## 13 Finally, there was a significant correlation (r 2 

## ) of soil organic matter cont ent and soil:water

partitioning coefficients. Soil:water partition coefficients normalized to the organic carbon

content of the soil (K

oc 

## ) were 815, 1196, 1294, 1385 and 1431 ml/g. EFED used the slope of K d 

## versus organic matter as the K

oc 

## (1345) for Tie r II (PRZM/EXAMS) modeling. This modeling

approach assumes that zoxamide sorption occurs on organic carbon only.

AQUATIC EXPOSURE AND RISK ASSESSMENT

Toxicity to Aquatic Animals :

Based on acceptable ecological effects data the Technical Grade Active Ingredient (TGAI) of

zoxamide is classified as:

 Highly toxic to freshwater fishes ( rainbow trout LC 50 

## 156 ppb, bluegill sunfish LC 50 

## >790 ppb) on an acute basis

 Practically non

- toxic to estuarine/marine fishes (sheepshead minnow LC 50 

## >860 ppb) on

an acu te basis

 Freshwater rainbow trout chronic NOAEC 3.48 ppb

- ( post hatchling survival rate

affected) and fathead minnow chronic NOAEC 60 ppb

- ( affected parameters

- length,

hatchling success, and 28

- D survival rate).

 Estuarine/marine sheepshead minnow chro nic NOAEC 40 ppb

- ( length affected at 250

ppb and 28

- Day survival and hatchling success were affected at >250 ppb)

 Highly toxic to freshwater invertebrates ( Daphnia magna EC 50 

## >780 ppb) on an acute basis

 Highly toxic to estuarine/marine invertebrate (Eastern Oyster LC 50 

## 715 ppb ) and very

highly toxic to saltwater invertebrates (mysid shrimp LC 50 

## 75 ppb) on an acute basis.

 Freshwater invertebrates Daphnia magna chronic NOAEC 39 ppb

- (survival rate

affected) and Freshwater invertebrate midge chronic NOAEC 210 ppb

 Estuarine/marine Mysid shrimp

- chronic NOAEC 7.2 ppb

- (reproduction and growth rate

affected)

Based on acceptable ecological effects data the Co

- Formulation (69% mancozeb + 8.26%

zoxamide) is classified as:

 Moderately toxic to fresh water fishes (rainbow trout LC 50 

## 1900 ppb) on an acute basis

 Moderately toxic freshwater invertebrates ( Daphnia magna EC 50 

## 3800 ppb) on an acute

basis

Aquatic Exposure Assessment

Aquatic exposures were based on estimated environmental concentratio ns (EECs) in surface water

from PRZM/EXAM modeling simulations for potatoes and grapes, the proposed commodities for

zoxamide. PRZM/EXAMS modeling uses a single site that represents a high

- end exposure

scenario for the use of a pesticide on a particular c rop or non

- crop use site. The meteorology and

## 14 agricultural practice are simulated at the site over multiple years (in this case, 23 and 36) such that

the probability of an EEC occurring at that site can be estimated. The EECs for use in the

ecological as sessment are provided in the following table:

TABLE 6. Tier II EECs of Zoxamide in Surface Water

Crop Peak (ug/L) 21 Days (μg/L) 60 Days (μg/L)

Potatoes

Grapes 2.3

7.5 0.6

2.1 0.4

1.1



## Aquatic Risk Assessment

The risk assessment integrates the results of the exposure and ecotoxicity data to evaluate the

likelihood of adverse ecological effects. Appendix D discusses the general EFED approach for

risk assessment, including discussion of risk quotients (RQs) and EFED levels of concern (LOCs).

Based on the ratio of the predicted EECs and the most sensitive species toxicity value, the

following risk determinations are predicted. Table 7 summarizes the findings of the risk analysis.

Table 7 Summary of

- Level of Concern (LOCs) Exceedances

Species Acute Risk (AR) Restricted Use

(RU) Endangered Species (ES) Chronic Risk

(CR)

freshwater fish

No No Yes No

AR: No exceedence

RU: No exceedence

ES: Levels Of Concern value ( > 0.05) were triggered for multiple application rate of 0.2 lbs ai/A grapes

CR: No exceedence

estuarine/marine

fish No No No No

AR: No exceedence

RU: No exceedence

ES: No exceedence

## 15 CR: No exceedence.

freshwater

invertebrates No No No No

AR: No exceedence

RU: No exceedence

ES: No exceedence

CR: No exceedence.

estuarine/marine

invertebrates No No Yes No

AR: No exceedence

RU: No exceedence

ES: Levels Of Concern value ( > 0.05) were triggered for multiple application rate of 0.2 lbs ai/A grapes

CR: No exceedence

Mammal Acute Risk (AR) Restricted Use

(RU) Endangered Species (ES) Chronic Risk

(CR)

None were exceeded No No No No

AR : No exceedence even using the highest application rate of 8 applications at rates 0.2lbs ai/A

- (potatoes and grapes)

RU: No exceedence even using the highest application rate of 8 applications at rates 0.2lbs ai/A

- (potatoes and grapes)

ES: No exceedence even using the highest application rate of 8 applications at rates 0.2lbs ai/A

- (potatoes and grapes)

CR: No exceedence even using the highest application rate of 8 applications at rates 0.2lbs ai/A

- (potatoes and grapes)

Birds No No No No

AR: No exceedence even using the highest application rate of 8 applications at rates 0.2lbs ai/A

- (potatoes and grapes)

RU: No exceedence even using the highest application rate of 8 applications at rates 0.2lbs ai/A

- (potatoes and grapes)

ES: No exceedence even using the highest application rate of 8 applications a t rates 0.2lbs ai/A

- (potatoes and grapes)

CR: No exceedence even using the highest application rate of 8 applications at rates 0.2lbs ai/A

- (potatoes and grapes)

non

- target insects N/A NA N/A NA



## Acute risk levels of concern (RQ > 0.5) are not triggered for freshwater fishes and invertebrates,

and estuarine/marine invertebrates using multiple applications at 0.20 lbs ai/A (Potatoes and

grapes scenarios)

Acute restricted use levels (RQ > 0.2) are not triggered for freshwater and estuarine fish and

invertebrates using multiple applications at 0.20 lbs ai/A (Potatoes and Grapes scenarios)

Chronic concern levels for freshwater fishes , fathead minnows are not triggered (RQ > 1.0) for

applications made at a rate of 0.20 lbs ai/A using g rapes and potatoes as the high end scenario

based on the full

- life cycle study. Rainbow trout levels of concern are not triggered for

applications made at a rate of 0.20 lbs. ai/A using grapes as the high end scenario and based on

the early

- life stage study

## 16 Chronic risk concerns for estuarine/marine fishes are not triggered (RQ > 1.0) for

estuarine/marine invertebrates using grapes and potatoes as the high end use scenario

Chronic concern levels for freshwater invertebrates are not triggered (RQ > 1.0) for multiple

applications at 0.20 lbs ai/A using grapes and potatoes as the high end scenarios.

Chronic concern levels for estuarine/marine invertebrates (RQ >

Table 8

- Ecotoxicity Comparison of mancozeb, zoxamide, and co

- formulated product using

freshwater rainbow trout 1.0) were not exceeded.

Acute endangered species concern levels (RQ > 0.05) for freshwater fishes and estuarine/marine

invertebrates are triggered using the grape scenario at an application rate of 0.20 lbs ai/A.

Comparative Assessment of Mancozeb, Zoxamide, and Co

- formulated toxicity

Based on acceptable available ecotox icity data using mancozeb, zoxamide, and the co

- formulated

product, zoxamide and mancozeb appear to be more toxic to freshwater fishes ( rainbow trout)

and invertebrates ( Daphnia magna ) than the co

- formulated product (Table 8 & 9). It is unknown if

the t oxicity differential for the co

- formulated product was due to the presence of zoxamide and

mancozeb in combination or the presence of multiple mixtures within the actual co

- formulated

product including the main degradate of mancozeb Ethylene thiourea (E TU). Also

, it is not

known if ETU played a toxic enzymatic role in decreasing the toxicity of both mancozeb and

zoxamide in co

- formulation or conversely, it is not known if ETU played a part increasing the

toxicity for mancozeb (TGAI) as ETU is the degrad ate that is formed after mancozeb degrades

very rapidly when dispersed into aquatic environments.

Species/Flow

Through %ai LC 50 Value

(ppb) Toxicity

Category MRID No./

Author/Year Study

Classification

Rainbow trout

( Oncorhynchus

mykiss)

Rainbow trout

( Oncorhynchus

mykiss) 94.2

Zoxamide

(TGAI)

69%mancozeb +

8.26% zoxamide 156

1900 Highly toxic

Moderately 447319

- 26

/Sword/1995

449505

- 03/

Rhodes/1998 Core

Core

Rainbow Trout

( Salmo

gairdneri)/ static 80.0

Mancozeb

(TGAI) 460

Highly toxic 40118502/Terr.&

Aquatic Bio.

Lab.,Beltsville,

MD/1980 Core

## 17 Table 9

- Ecotoxicity Comparison of mancozeb, zoxamide, and co

- formulated

product using the freshwater daphnid.

Species %ai EC 50 (ppb) Toxicity

Category MRID/Author/

Year Study

Classification

Daphnid

( Daphnia magna )

Daphnid

( Daphnia magna ) 94.2%

Zoxamide

(TGAI)

69% mancozeb +

8.26 Zoxamide > 780

3800 Highly toxic

Moderately

toxic 447319

- 20/

Sword/ 1995

449505

- 02/

Madsen/1998 Core

Core

Daphnid

( Daphnia magna ) 80.0

Mancozeb

(TGAI) 580 Highly toxic 40118503/Terr &

aquatic Biology

Lab MD/1980 Core



## As for non

- target insects, mancozeb, zoxamide, and its co

- formulated product do not

show any significant toxicological differences. In each case the toxicity rating still shows

that all three are practically non

- toxic to non

- target insects (Table 10).

Table 10

- Non

- target insect toxicity using zoxamide, co

- formulated product, and

mancozeb

Species/(Static

Renewal) % ai LD 50

(ug/bee) Toxicity

Category MRID No.

Author/Year Study

Classification

Honeybee

( Apis mellifera )

Honey bee

( Apis mellifera )

Honey bee

( Apis mellifera ) >95%

Zoxamide

(TGAI)

69% mancozeb &

8.3% Zoxamide

72.%

Mancozeb

(TGAI) >153 ug ai/bee

>200 ug ai/bee

>178.87 ug/bee Practically

non

- toxic

Relatively

Non

- toxic

Relatively

Non

- toxic 447319

- 19/

Kirkland/1993

449505

- 04/

Engelhard/1997

00018842/Atkins/

1969 Core

Core

Core

## 18 Risk Quotient Calculation for Aquatic Organisms

Based on the ratio of the predicted EECs and the most sensitive species toxicity value, risk

quotient calculations were performed using the guidance in Appendix D. The risk quotients for

aquatic organisms are presented in Tables 11

- 16.

Table 11

- Risk q uotients for Freshwater fishes using the Rainbow Trout And

PRZM/EXAM Modeling

Site LC 50 (ppb) NOAEC

(ppb) PRZM/EXAM

Initial

(ppb) PRZM/EXAM

60 day

(ppb) Acute

Risk

quotient Chronic

Risk

Quotient

Grapes

(0.2 lbs ai/A, 8

applications, 7

day intervals)

Potatoes

(0.2 lbs ai/A, 8

applications, 5

day intervals) 156 ppb

(Rainbow

trout

Onchorynchus

mykiss)

156 ppb

(Rainbow

trout

Onchorynchus

mykiss) 3.48

Rainbow

trout

( Onchorynchu

s mykiss)

3.48

Rainbow

trout

( Onchorynchu

s mykiss) 7.5

2.3 1.1

0.4 0.05

0.015 0.32

0.11



## Table 12

- Freshwater Fish Early Life

- Stage Toxicity Under Flow

- through Conditions

Site NOAEC

(ppb) PRZM/EXAMS

60

- Day Chronic

Risk

Quotient

Grapes,

(0.2 lbs ai/A, 8 applications, 7

day intervals)

Potatoes

(0.2 lbs ai/A, 8 applications, 5

day intervals) 3.48

3.48 1.1

0.4 0.32

0.11



## Table 13

-- Risk Quotients For Early Life

- Stage Freshwater Fish Using The Fathead

minnow

## 19 Site NOAEC

(ppb) PRZM/EXAMS

60

- Day

(ppb) Chronic

Risk

Quotient

Grapes,

(0.2 lbs ai/A, 8 applications, 7

day intervals)

Potatoes

(0.2 lbs ai/A, 8 applications, 5

day intervals) 60

60 1.1

0.4 0.018

0.007



## Table 14

- Risk Quotients For Freshwater Invertebrates Using the **Daphnia magna**

And PRZM/EXAMS Modeling.

Site EC 50 (ppb) NOAEC

(ppb) PRZM/EXAMS

Initial

(pbb) PRZM/EXAM

21

- day

(ppb) Acute

Risk

Quotient Chronic

Risk

Quotient

Grapes,

(0.2 lbs ai/A, 8

applications, 7

day intervals) > 780

Daphnid

Daphnia

magna ) 39

Daphnid

Daphnia

magna ) 7.5 2.1 <0.01 0.05

Potatoes

(0.2 lbs ai/A, 8

applications, 5

day intervals) 3800

Daphnid

Daphnia

magna ) 39

Daphnid

Daphnia

magna ) 2.3 0.6 0.0006 0.015



## Table 15

-- Risk Quotients For Estuarine/marine fishes using the sheepshead

minnow and PRZM/EXAMS Modeling

Site EC 50 NOAEC

(ppb) PRZM/EXAM

Initial

(ppb) PRZM/EXAM

60

- day

(ppb) Acute

Risk

Quotient Chronic

Risk

Quotient

Grapes,

(0.2 lbs ai/A, 8

applications, 7

day intervals)

Potatoes

(0.2 lbs ai/A, 8

applications, 5

day intervals) >860

Sheepshead

minnow

( Cyprinodon

variegatus )

>860

Sheepshead

minnow

( Cyprinodon

variegatus ) 40

Sheepshead

minnow

( Cyprinodon

variegatus )

40

Sheepshead

minnow

( Cyprinodon

variegatus 7.5

2.3 1.1

0.4 <0.009

<0.003 0.03

0.01

## 20 Table 16

-- Risk Quotients for Estuarine/marine invertebrates using the mysid

shrimp and PRZM/EXAMS Modeling

Site EC 50 (ppb) NOAEC

(ppb) PRZM/EXAM

Initial

(ppb) PRZM/EXAM

21

- Day

(ppb) Acute

Risk

Quotient Chronic

Risk

quotient

Grapes,

(0.2 lbs ai/A, 8

applications, 7

day intervals)

Potatoes

(0.2 lbs ai/A, 8

applications, 5

day intervals) 75

75 7.2

7.2 7.5

2.3 2.1

0.6 0.1

0.03 0.29

0.08



## Aquatic Organism Risk Characterization

Risk to aquatic organisms are expected to be low even when the high end use rate for

zoxamide (0.2 lbs ai/A at 8 applications per year) is used. No levels of concern (LOCs)

were exceeded and therefore it is concluded that aquatic organisms will be at low risk

when multiple applications are used. However, the Agency’s level of concern for endangered

and threatened freshwater fish and estuarine/marine invertebrates is exceeded for the proposed use

of zoxamide on grapes.

TERRESTRIAL EXPOSURE AND RISK ASSESSMENT

Toxicological Profile

Based on acceptable ecotoxicity effects data the Technical Grade Active Ingredient (TGAI) of

zoxamide is classified as:

 Practically non

- toxic to avian (Bobwhite Quail) on an acute basis (LD 50 

## >2000

mg/kg)

 Practically non

- toxic to avian species (B obwhite Quail) on a subacute dietary

toxicity basis (LC 50 

## >5250 ppm)

 Practically non

- toxic to mammals on an acute oral toxicity basis (LD 50 

## = >5,000

mg/kg)

 Practically non

- toxic to non

- targeted insects on an acute basis (LD 50 

## = >100

ug/bee)

## 21  Practically non

- toxic to mammals on a chronic reproductive basis (NOAEL=20,000

ppm)

 Practically non

- toxic to avian species on a chronic reproductive basis (NOAEC

1000ppm)

 Practically non

- toxic to earthworm species on a chronic reproductive basis

(NOAEC 2000 ppm)

Based on acceptable ecological effects data the Co

- Formulation (69% mancozeb + 8.26%

zoxamide)is classified as:

 Practically non

- toxic to non

- targeted insects on an acute basis (LD 50 

## = >153

ug/bee)

Terrestrial Exposure

Initial zoxamide residue levels on vari ous types of vegetation from single applications

are based on research of Hoerger and Kenaga (1972) and later modified by Fletcher et al.

(1994). Estimated terrestrial exposure levels of multiple application residues available

for dietary ingestion were g enerated by calculating first

- order decay of a chemical applied

to foliar surfaces. The foliar dissipation half

- life was set at a default 35 days because

foliar dissipitation data were not available. The ELL

- FATE Model was used for the

purpose of genera ting terrestrial EECs. EECs were generated for potatoes and grapes

set at an application rate of 0.20 lbs ai/A. This program calculates the decay of a

chemical pesticide applied to foliar surfaces for single and multiple applications. The

foliar diss ipation rate is based on a number of routes which include photolysis, hydrolysis

and volatilization. Moreover, the program calculates concentrations on each type of

food or plant surface on a daily interval for one year (365 days). The maximum

concentrat ion during the year and the highest average 56

- days concentration are

calculated. The calculated concentrations are used to derive both avian and mammalian

Risk Quotient (RQ’s) values. The maximum calculated concentration is divided by the

user input val ues for the chronic NOAEL and acute LC 50 

## to give Risk Quotients for each

type of plant surface.

Avian Risk

Predicted exposure levels on food sources were divided by the most sensitive dietary

LC 50 

## (>5,250 ppm) or the chronic NOAEL (1000 ppm). Results are presented in Table 17 .

Based on these results, there is a low risk for birds. Therefore, zoxamide will pose

minimal risk to avian species at the suggested application rates for multiple applications

using rates for potatoes and grapes (0. 20 lbs ai/A)

.

## 22 Table 17

-- Multiple Applications of Zoxamide for Avian Species

Site Food Items Maximum

EECs

(ppm)

Chronic Maximum

EECs

(ppm **)**

For acute LC 50 (ppm) NOAEC

ppm Acute RQ

(EEC/LC 50 Chronic RQ

(EEC/NOAEC)

Grapes/

Aerial/

0.2 lbs ai/A 8

times per yr Short Grass

Tall Grass

Broadleaf

plants/insects

Seeds 248.48

113.89

139.77

15.53 248.48

113.89

139.77

15.53 >5250 1000 <0.05

<0.02

<0.03

<0.01 0.25

0.11

0.14

0.015

Potatoes/

Aerial/

0.2 lbs ai/ Short Grass

Tall Grass

Broadleaf

plants/insects

Seeds 278.57

127.68

156.70

17.41 278.57

127.68

156.70

17.41 >5250 1000 <0.05

<0.02

<0.03

<0.01 0.30

0.13

0.16

0.02



## Mammalian Risk

Terrestrial risk estimates for both crops were calculated based on the exposures

generated from the application rate and application interval of each crop and the avian

and mammalian toxicity. Each crop represents the best case scenario in which avian

and mammalian species may be exposed. Calculations for mammalian risk quotients

were based on a laboratory mouse LD 50 

## value >5,000 mg/kg (MRID 44731837) and a

chronic reproductive effects observed at 20,000 ppm (MRID 44770001). Results can

found in Tables 18

- 20.

Predicted levels of risk for mammals were as follows:

 Acute Levels Of Concerns( RQ> 0.5) for herbivorous/insectivorous

mammals were not triggered by estimated exposures to multiple applications of

zoxamide at a rate of 0.20 lbs ai/A for both scenarios. Therefore, risks to

herbivorous/insectivorous mammals are expected to be low from the

consumption of food items treated with zoxamide.

 Acute Restricted Use Concerns for most mammals ( RQ > 0.2) were not

triggered by multiple applications at 0.20 lbs ai/A for the two scenarios

 Chronic levels of concerns ( RQ > 1.0) for herbivorous/insectivorous

mammals were not triggered for the four modeled multiple application crop

scenarios (grapes and potatoes @ 0.20 lbs ai/A ), therefore risk to mammals is

expected to be low from the consumption of food items treated wi th zoxamide.

 Acute Endangered Species Concerns (RQ > 0.1) for all classes of

herbivorous/insectivorous mammals ( up to 35 grams) were not triggered

using both multiple applications scenarios (use rate 0.20 lbs ai/A)

## 23 Table 18

-- Mammalian (Herbivore/Insect ivore) Acute Risk Quotients For Multiple

Applications Of Non

- granular Products(Broadcast) Based on Rattus norvegicus

LD 50 

## of >5,000 mg/kg

Site/App.

Method/

App Rate/

No. Of App Body

weight

(grams) % Body

weight

Consume

d Rat

LD 50 (mg/kg) EEC

(ppm)

Short

Grass EEC

(ppm)

Forage &

Small

Insects EEC

(ppm)

Large

Insects Acute

RQ

Short

Grass Acute

RQ

Forage

Small

Insects Acute

RQ

Large

Insects

Grapes/

Aerial/

0.2 lbs ai/A 8

times per yr 15

35

1000 95

66

15 >5,000

>5,000

>5,000 248.48

248.48

248.48 113.89

113.89

113.89 139.77

139.77

139.77 <0.05

<0.03

<0.01 <0.02

<0.02

<0.01 <0.03

<0.02

<0.01

Potatoes/

Aerial/

0.2 lbs ai/ 15

35

1000 95

66

15 >5,000

>5,000

>5,000 278.57

278.57

278.57 127.68

127.68

127.68 156.70

156.70

156.70 <0.05

<0.04

<0.01 <0.02

<0.02

<0.01 <0.03

<0.02

<0.01

1

Mammalian RQ’s = EEC

LD 50 / (%Body weight Of Mammals)



## Table 19

-- Mammalian (Granivore) Acute Risk Quotients for Multiple Applications of

Non

- granular Products (Broadcast) based on Rattus norvegicus LD 50 

## of >5,000 mg/kg

Site Body Weight

(g) %Body Weight

Consumed Rat LD 50 (mg/kg) EEC

(ppm)

Seeds Acute RQ 1 Seed

Grapes/Aerial/

0.2 lbs ai/A 8 times

per yr

15

35

1000 21

15

3 >5000

>5,000

>5,000 15.53

15.53

15.53 <0.01

<0.01

<0.01

Potatoes/

Aerial/

0.2 lbs ai/ 15

35

1000 21

15

3 >5000

>5,000

>5,000 17.41

17.41

17.41 <0.01

<0.01

<0.01

1 

## Mammalian RQ=

Table

- 20

- Mammalian (Granivore) Chronic Risk Quotients For Multiple

Applications of Non

- granular products (Broadcast) based on Rattus norvegicus

NOAEL of 20,000 ppm EEC

LD 50 

## /(%Body Weight)

Site/

Application

rate/

Number of

application Rat NOAEL

Toxicity

(ppm)

Value EEC

(ppm)

Short Grass EEC

(ppm)

Forage &

Small

Insects EEC

(ppm)

Large

Insects Chronic

Risk

Quotient

Short Grass Chronic

Risk

Quotients

(Forage &

Small

Insects) Chronic

Risk

Quotients

(Large

Insects)

## 24 Grapes/

Aerial/

0.2 lbs ai/A 8

times per yr 20,000 248.48 113.89 139.77 0.01 0.006 0.007

Potatoes/

Aerial/

0.2 lbs ai/ 20,000 278.57 127.68 156.70 0.01 0.006 0.008



## Semi

- Aquatic And Terrestrial Plant Exposure And Risk Assessment

Based on valid semi

- aquatic and terrestrial plant ecotoxicity data, TGAI zoxamide is:

 Toxic to semi

- aquatic plants ( S.capricorntum EC 50 

## 23 ppb, Scenedesmus

subspicatus , EC 50 

## 10 ppb, Lemna gibba EC 50 

## 19ppb)

 Toxic to freshwater diatoms (EC 50 

## >930 ppb), Marine diatoms (EC 50 

## >910 ppb),

and Freshwater Alga (EC 50 

## >860 ppb)

Based on valid semi

- aquatic and terrestrial plant ecotoxicity data, the Co

- Formu lation (69%

mancozeb + 8.26% zoxamide)is classified as:

 Toxic to semi

- aquatic plants { Lemna gibba (duckweed) EC 50 

## 19ppb,

Scenedesmus subspicatus (freshwater alga) EC 50 

## 10 ppb}

Table

- 21

-- Risk Quotients For Terrestrial and Semi

- aquatic plants

Species Application Site EC 50 (ppb) PRZM/EXAMS

(ppb) Acute

Value

Navicula pelliculosa

(freshwater diatom) Grapes

(0.2 lbs ai/A, 8

applications, 7 day

intervals)

Potatoes > 930 7.5 <0.08

## 25 (0.2 lbs ai/A, 8

applications, 5 day

intervals)

>930 2.3 <0.02

Lemna gibba

(Duckweed) Grapes

(0.2 lbs ai/A, 8

applications, 7 day

intervals)

Potatoes

(0.2 lbs ai/A, 8

applications, 5 day

intervals) 19

19 7.5

2.3 0.40

0.12



## Terrestrial Risk Characterization

Risk to mammals are expected to be low even when the high end use rate for zoxamide

(0.2 lbs ai/A at 8 applications per year) is used. No levels of concern (LOCs) were

exceeded and therefore it is concluded that mammals will be at low risk when multiple

applications are used .

Risk quotients for non

- target insects are not estimated, however, an acceptable study

(MRID #447319

- 19 and #449505

- 04) suggest that zoxamide is practically non

- toxic to

non

- target insects.

EFED’s assessme nt suggests that no ecological risk concerns are posed to birds from the

use of this fungicide at the acute and chronic levels. No LOCs were exceeded for birds

when using the high end use scenarios for potatoes and grapes. (Table 17).

ENDANGERED SPECIES

The Agency’s level of concern for endangered and threatened freshwater fish and estuarine/marine

invertebrates is exceeded for the proposed use of zoxamide on grapes (note that there are currently

no endangered estuarine invertebrates). The registrant must provide information on the proximity

of Federally listed freshwater fish and estuarine/marine invertebrates to the proposed use sites.

This information may best be provided via the FIFRA Endangered Species Task Force (Pesticide

Registration [PR] Noti ce 2000

- 2) but may be produced independently, providing the information

is of sufficient quality to meet FIFRA and Endangered Species Act requirements. The

information will be used by the OPP Endangered Species Protection Program to develop

recommendation s to avoid adverse effects to listed species

.

## 26 APPENDIX A

ENVIRONMENTAL FATE DISCUSSION

and

STRUCTURES OF ZOXAMIDE AND DEGRADATES

## 27 Degradate Environmental Fate and Transport

Degradation

Hydrolysis (161

- 1)

-- An experiment to assess the hydrolysis of [ 14 

## C]RH

- 117281 at a concentration

of 0.5 ppm was conducted in the dark at 25 ± 1 **°** C in sterile aqueous buffered solutions at pH 4, pH

7 and pH 9. The first

- order linear regression calculated half

- lives of [ 14 

## C]RH

- 1172 81 were 15.5,

15.7 and 8.1 days for pH 4, pH 7 and pH 9, respectively. The four major (>10% of parent

compound) transformation products were:

1.) RH

- 150721 ( CAS: Benzoic acid, 3,5

- dichloro

- 4

- methyl, 3

- amino

- 3

- methyl

- 2

- oxopentyl ester)

, 2.) RH

- 24549 ( CAS: Benzoic acid, 3,5

- dichloro

- 4

- methyl ),

3.) RH

- 141288 ( CAS: Benzamide,

3,5

- dichloro

- N

- (1

- ethyl

- 3

- hydroxy

- 1

- methyl

- 2

- oxopropyl)

- 4

- methyl )

4.) RH

- 129151 ( CAS: 4 H

- 1,3

- Oxazin

- 5(6 H )

- one,

2

- (3,5

- dichloro

- 4

- methylphenyl)

- 4

- ethyl

- 4

- methyl ).

These account ed for maximums of 37.6 % (pH 4), 30.9 % (pH 4), 50.2% (pH 9) and 24.5% (pH 7),

respectively of the total applied parent compound. The table below shows the EFED (using first

order linear regression) and registrant calculated (using nonlinear regression i n SAS) half

- lives of

the degradates, if they could be calculated; the “<10%” means the concentration was <10% of

applied radioactivity and no half

- life was calculated, and “stable” means that the degradate either

kept increasing or reached a plateau and di d not decrease during the study:

pH 4 pH 7 pH 9

EFED Registrant 

## EFED Registrant 

## EFED Registrant



## RH

- 129151 <10% <10% 28.5 days 9.1 days 9.9 days 2.4 days

RH

- 150721 22 days 18.3 days <10% <10% <10% <10%

RH

- 24549 stable stable stable stable stable stable

RH

- 141288 <10% <10% stable stable stable stable

Up to nine minor transformation products were detected, none of which exceeded 10% of the

applied parent compound. The radioactivity balance ranged from 90.8 to 96% of the initial

radioactivity. The data show that hydrolysis, especially at pH 9, is an imp ortant

degradation process of zoxamide. The data requirement for hydrolysis is satisfied. (MRID

44731908 and 44731909 )

Photodegradation in water (161

- 2)

-- The aqueous phototransformation of [ 14 

## C]RH

- 117281 was

studied at ~25 **°** C in sterile aqueous buffered solutions at pH 4, at an initial concentration of 0.5

mg/L under artificial light for 30 days. The half

- life of [ 14 

## C]RH

- 117281, calculated by linear

regression by the registrant and uncorrected for the dark control, was 7.8 days. The half

- life was

## 28 12 days when corrected for the dark control. The dark control half

- life was 22.4 days. EPA

notes that the half

- life in the pH 4 hydrolysis study was 15.5 days. If the pH 4 study half

- life is

used as the dark control, then the aq ueous photolysis half

- life is 15.7 days. Combining the two

half lives give a mean of approximately 14 days which was used in modeling. The mass balance

was 98.1 and 98.9% for the irradiated and control samples, respectively. The total CO 2 

## and other

volatile compounds amounted to < 0.2 and < 0.3% of the applied radioactivity, respectively. The

major transformation products were:

1.) RH

- 150721, (CAS: Benzoic acid, 3,5

- dichloro

- 4

- methyl, 3

- amino

- 3

- methyl

- 2

- oxopentyl

ester)

2.) RH

- 24549, ( CAS: Benzoic acid, 3,5

- dichloro

- 4

- methyl )

3.) RH

- 139432, (CAS: Benzamide, 3,5

- dichloro

- 4

- methyl )

These accounted for maximums of 15, 27.7 and 42.4% of the applied radioactivity in irradiated

samples, respectively.

This study satisfies the guideline r equirement for a phototransformation study in water. (MRID

44731911)

Photodegradation on soil (161

- 3)

-- The phototransformation of zoxamide was studied on sandy

loam soil for 30 days at 25 **°** C. Test and dark control soil samples were treated with 1 ppm

rad iolabeled zoxamide equivalent to 2000 g ai/ha. The test samples were irradiated under artificial

light.

Photodegradation of zoxamide on soil does not appear to be a major route of dissipation because

the half

- lives in irradiated and dark control samples w ere similar, 10.2 and 11.7 days, respectively.

Correcting for the dark control half

- life produced a soil photolysis half

- life of 78 days, also

indicating a little soil photodegradation . Furthermore, the pattern of transformation products

formation was ve ry similar in the irradiated samples and the dark controls. It appears that

degradation was primarily microbial or hydrolytic and not due to photolytic processes.

The mass balance was 102.23 and 100.22% for the irradiated and control samples, respectivel y.

The total recovery of radiolabelled CO 2 

## and volatile compounds was minor, averaging 0.34% for

irradiated samples and 0.29% control samples. Mean total radiocarbon as bound residues (in the

post extraction solid (PES).

Soil bound residues acc ounted for 32% of the applied radioactivity. fraction) on day 30 was

30.77% and 31.86% for irradiated and control samples. Less than 1% of the applied radioactivity

was CO 2 

## . In addition to the parent compound, 12 other transformation products were detect ed

during the 30 day study. The major transformation product (RH

- 24549 or 3,5

- dichloro

- 4

- methyl

benzoic acid) accounted for approximately 22% of the applied dose. Another transformation

product (RH

- 127450, a dechlorination product of the parent chemical), which accounted for nearly

11% of the total applied radioactivity at Day 14. The third most prevalent transformation product

## 29 (# 1) reached a maximum of 6.73% of the total applied dose at Day 21 and was proposed as a

dihydroxy product. The concentration of all other transformation products was never greater than

4% of the applied dose. This study is acceptable and satisfies the guideline requirement for a

phototransformation study on soil.(MRID 44731910 )

Metabolism

Aerobic soil metabolism 162

- 1)

-- The biotr ansformation of zoxamide was studied on loamy sand

and silt loam soils for 122 d under aerobic conditions at 25 **°** C, pH 6.8

- 6.9 and 75% field moisture

capacity (FMC) at 1.5 mg a.i/kg dry soil. The DT 50 

## s of RH

- 117281 in soil were 14 d (loamy

sand) and 7

- 14 d (silt loam) based on a visual examination of the dissipation curves. Using 1 st



## order linear regression of time vs. natural log of the concentration, EFED determined the half

- lives

to be 38.1days (loamy sand) and 37.5 days (silt loam). The total CO 2 

## and other volatile

compounds released at the end of the 122 d incubation period amounted to 34.36% (loamy sand

soil) and 47.77 % (silt loam soil) of the applied amount. No transformation products were

detected in concentrations > 10% of applied radioactivity . The major transformation pathway of

zoxamide was to CO 2 

## via the transformation products RH

- 139432 and RH

- 24549. After 122 d,

13.59

- 23.59% and 33.01

- 38.43% of the applied amount of radioactivity was present in the test

soils as extractable and bound resi dues, respectively. The overall average mass balances were

98.42% (loamy sand) and 97.03% (silt loam). This study is acceptable and satisfies the guideline

requirement for a biotransformation study in aerobic soil. (MRID 44731912 )

Anaerobic soil metabolism (162

- 2)

-- Zoxamide (1.5 ppm) was studied in a pH 7.2 sandy loam

soil for 59 days under anaerobic conditions at 25 + 1 **°** C and 75 % moisture. The half

- life of

zoxamide in soil was 14.6 days.

The total CO 2 

## and volatile compounds released amounted to ~ 5 % of the applied dose, indicating

little if any oxidative mineralization. The average total 14 

## C recovery throughout the 59

- day study

was 99.04 %. Parent chemical and eleven transformation products were observed in this study.

Two major transformat ion products were detected: RH

- 24549 (2,5

- dichloro

- 4

- methyl benzoic

acid) and RH

- 127450 (a dechlorination product); the concentrations of other transformation

product did not exceed 5 %.

The total amount of radioactivity remaining as parent compo und was determined to be 47.39 % at

the beginning of anaerobic incubation (day 0) and decreased to 2.43 % by day 59. At the end of

59

- day incubation period under anaerobic conditions, the amount of total extractable residues

decreased from an average of 67 .84 % at day 0 to 45.24 % of the applied dose, whereas the amount

of bound residue in the post extraction solids (PES) increased from 27.26 % at day 0 to 53.50% of

the applied dose. The majority of the radioactivity was extracted into the organic phase.

I t should be noted by the registrant that EFED prefers the submission of the anaerobic aquatic

metabolism study instead of the anaerobic soil metabolism study. The anaerobic aquatic

metabolism study provides more information related to patterns of formati on and decline of parent

and major degradates, half

- life, etc., through the use of more frequent sampling intervals and a

## 30 longer sampling period (generally up to a year). It should be noted that in future submissions, the

anaerobic aquatic metabolism stud y will be required. Furthermore, the redox potential should be

measured in future studies to verify that anaerobic conditions occurred.

This study is acceptable and satisfies the guideline requirement for a biotransformation study in

anaerobic soil. (MR ID 44731914 )

Aerobic aquatic metabolism (162

- 4)

-- This study is classified as acceptable and shows that

zoxamide degradates in the water + sediment with half

- lives of 3.6 and 7.6 days, respectively in

river and pond systems.

The biotransformation of [ 14 

## C ]RH

- 117281 was studied in river and pond sediment/water systems

for 106 d under aerobic conditions at 20 **°** C and 10 **°** C and pH 7

- 8 at an application rate of 0.072 mg

a.i/L. The registrant determined the half

- lives in the water, sediment and total system (wate r +

sediment) by use of first order non

- linear regression. The decline times (DT 50 

## ) of [ 14 

## C]RH

- 117281

in the water + sediment of system 1 (Rhine River) were: 7.0 d (20 **°** C) and 10.9 d (10 **°** C ).

Similarly, the decline times in the water + sediment of system 2 (pond, Judenweiher) were:6.1 d

and 21.0 d, respectively.

Since Tier I and Tier II models for estimating drinking water concentrations are based on first

order kinetics, EFED used a linear first order model to estimate the aerobic aquatic metabolism

hal f

- lives for zoxamide in the total systems (water + sediment). The total system is used because

total degradation can be accounted for without considering the impact of adsorption on pesticide

removal. The coefficient of determination (R 2 

## = 0.97, 0.99, 0.96 , and 0.95) indicates the linear first

order model adequately describes the variability in the data. The first order linear regression (time

vs. natural logarithm of the percent concentration remaining) produced the following half

- lives:

Rhine River: 3.6 d (20 **°** C) and 10.9 d (10 **°** C ); Pond system:7.6 d (20 **°** C) and 14.5 d (10 **°** C).

The total CO 2 

## and volatile compounds released during the 106 d incubation period in system 1,

amounted to 21.9% (20 **°** C) and 6.5% (10 **°** C) of the applied amount. In system 2, the

corresponding values were 19.7% and 4.0%, respectively. The mass balance in system 1 was

98.0 ± 2.4% (20 **°** C) and 96.8 ± 2.3% (10 **°** C) and in system 2, it was 97.5 ± 2.5% (20 **°** C) and 96.4 ±

1.8% (10 **°** C). The major transformation products detected were RH

- 127450 (IUPAC:

3,5

- Dichloro

- N

- (1

- ethyl

- 1

- methylacetonyl)

- p

- toluamide) and RH

- 163353 (name not specified).

The major pathway of transformation of [ 14 

## C]RH

- 117281 was dechlorination, followed by ring

closure and oxidation. In system 1, maximums of 64.4% (2 0 **°** C) and 71.7% (10 **°** C) of the applied

radioactivity partitioned from the water into the sediment. In system 2, maximums of 79.3 %

(20 **°** C) and 83.2% (10 **°** C) of the applied radioactivity partitioned from the water into the sediment.

In system 1, at the end of the 106 d incubation period, 16.7%, 27.8% and 36.6% of applied amount

was present in the water, sediment extractable and sediment

- bound residues, respectively at 20 **°** C.

The corresponding values at 10 **°** C were: 22.5%, 31.0%, and 33.5%, respectively. In syst em 2, at

the end of the 106 d incubation period, 6.9%, 33.0% and 39.0% of applied amount was present in

the water, sediment extractable and sediment

- bound residues, respectively at 20 **°** C. The

corresponding values at 10 **°** C were: 10.7%, 43.3%, and 37.3%, resp ectively.

- This study satisfies

## 31 the guideline requirement for a biotransformation study in aerobic sediment/water (MRID

44770002 )

Mobility

Leaching/adsorption/desorption (163

- 1)

-- EFED concludes that parent zoxamide does not

appear to have the potential to be mobile in the soil.

The adsorption/desorption characteristics of [ 14 

## C]RH

- 117281 were studied for 2 or 24 hours in

five soils (loam, sandy loam

, silty clay loam

, sandy loam and silty loam) from the U.S. The

adsorption K d 

## and K

oc 

## values 3.4, 10.3, 12 .4, 15.2, and 25.3 L/Kg and 815, 1196, 1294, 1385, and

1431L/Kg, respectively. The percent of the applied radioactivety adsorbed in soils ranged from

33.3 to 80.4%. The desorption K d 

## and K

oc 

## values ranged from 4.2 to 29.6 L/Kg and 927 to 1671

L/Kg, respec tively. The percent of adsorbed amount desorbed in soils ranged from 16 to 61.8%.

The desorption K d 

## and K

oc 

## values were similar to those obtained for adsorption. The mass

balance at the end of study amounted to > 97%. The authors stated that little, if any, parent,

degraded during the equilibrium phase of the studies and they assumed that all of the radioactivity

was due to parent zoxamide. Therefore, the adsorption/desorption characteristics of the soils

were c alculated based only on the radioactivity and not on concentration of parent in water and

soil.

The coefficient of determination (r2) values for the K d 

## values versus the soil organic carbon

content, pH, cation exchange capacity, and clay content were 0.8 37, 0.178, 0.551, and 0.584,

respectively. Only the correlation between K d 

## and soil organic carbon was significant.

No additional information on the mobility of unaged zoxamide in soil is required at this time. To

fulfill the data requirement, data are required on the mobility of zoxamide degradates that were

detected in the other laboratory studies at concentrations > 10% of applied radioactivity. Batch

equilibrium studies using radiolabeled synthesized degradates may be necessary to assess

degradate m obility.

In order to determine whether the K

oc 

## model is valid (i.e., K d 

## correlates with the organic carbon

content of the soils analyzed), and subsequently which value to use (either K d 

## or K

oc 

## ) in the

models, a plot of K d 

## vs. %OC was performed and checked for a significant correlation. This

was done by running a linear regression between the two variables. The F

- test (see below)

indicated that a significant correlation exists between K d 

## and %OC; therefore, the slope (1345

L/kg) of the regress ion between K d 

## and %OC is the K

oc 

## to be used in PRZM/EXAMS modeling.

For GENEEC modeling the lowest non

- sand K

oc 

## is used.

The average soil distribution coefficients for adsorption, K d 

## ads, the adsorption coefficient

normalized for organic carbon, K

oc 

## as well as the desorption coefficients, K d 

## des, are given below:

SOIL %OC K d 

## ads K d 

## des K

oc 

## ads K

oc 

## des 1/N

## 32 Loam 1.27 10.35 11.78 815 927 .896

Sandy loam 0.26 3.36 4.21 1294 1618 .986

Silty clay

loam 1.77 25.33 29.57 1431 1671 .963

Sandy Loam 1.10 15.23 15.56 1385 1415 .953

Silty Loam 1.04 12.44 10.73 1196 1032 1.067



## This study is marginally acceptable and partially fulfills the leaching/adsorption/desorption by

providing information on the mobility (batch equilibrium) of unaged zoxamide in loam, sandy

loam

, silty clay loam

, and silty loam soils. (MRID 44731916 )

Dissipation

Field dissipation (164

- 1)

-- Soil dissipation/accumulation of RH

- 7281 under US field conditions

was conducted in bare plots at 2 sites, one in Madera, California and the other one in Lyons, New

York. The sites at Madera and Lyons were in ecoregions California mediterranean and Mixed

wood plains, respectively. The registrant calculated the half

- lives from non

- linear regression of

time vs. zoxamide concentration after multiple applications. Under field conditions at Madera,

RH

- 7281 had a DT 50 

## value of 5.8 days in a loamy sand. Under field conditions at Lyons,

RH

- 7281had a DT 50 

## value of 8.2 days in a sandy soil. The DT 90 

## s were < 30 days.

RH

- 7281dissipated from the maximum residue level of 0.5 mg a.i./kg soil at Day 0 (0

- 7.5 cm

depth) to or below the limit of detection at 0.003 mg a.i./kg soil by Day 91. At the end of the 91

day period, there was no carryover of residues. The trans formation products of RH

- 7281 were

neither identified nor was their fate monitored. An additional field dissipation study was also

conducted in New York with a single application of zoxamide. The nonlinear half

- life was 5.5

days.

EPA calculated the half

- lives from linear regression of time vs. natural logarithm of the

concentration. The half

- lives were 11.5 and 17.7 days, respectively, for the California and New

York soils with multiple applications, and 15 days in the New York soil with a single applic ation.

The storage stability study showed an approximate 25% and 35% decrease after 280 and 365 days

of storage, respectively based on extrapolation from the regression curve of time in storage vs.

concentration. Furthermore, the individual data show a significant amount of variation in

recovery after storage, ranging from 113 to 50.8%. This study does not satisfy the guideline

requirement for terrestrial field studies of dissipation in the California and New York because the

fate of transformati on products, detected in the laboratory studies, has not been described and

because there are insufficient data on the stability of zoxamide during storage. (MRID

44732127 )

Soil dissipation of RH

- 7281 under Canadian field conditions was conducted in ba re plots at 3 sites:

(1) Minto, Manitoba, (2) Branchton, Ontario and (3) Hunter River, Prince Edward Island. Under

field conditions at Minto, RH

- 7281 had a DT 50 

## value of 4.6 days in a loam. Under field

## 33 conditions at Branchton, RH

- 7281had a DT 50 

## value of 9.0 days in a silt loam. Under field

conditions at Hunter River, RH

- 7281had a DT 50 

## value of 15 days in a sandy loam.

RH

- 7281dissipated from the maximum residue level of 0.5 mg a.i./kg soil at Day 0 (0

- 7.5 cm

depth) to or below the limit of detection at 0. 003 mg a.i./kg soil by Day 231. No carryover of

residues to the next field season is expected to occur based on these data. The transformation

products of RH

- 7281 were neither identified nor was their fate monitored.

The residues of RH

- 7281 were primari ly detected in the top (0

- 7.5 cm) soil layer. Plant uptake

and volatilization were not measured. The major routes of dissipation of RH

- 7281 under terrestrial

field conditions are unknown. The mass accounting could not be calculated because

volatilization , bound residues and/or plant uptake were not measured.

EPA calculated the half

- lives from linear regression of natural logarithm vs. time of the

concentration in the 0

- 15 cm soil depth. The half

- lives were 9.4, 14.2, and 68.6 days,

respectively, for th e Manitoba, Ontario and Prince Edward Island soils after 10 applications of 200

g ai/ha (0.18 lb ai/A).

The registrant

- calculated half

- lives for the three field sites were determined based on data for the

0

- to 3

- inch (0

- to 7.5

- cm) depth only and, theref ore, are of questionable worth. It is necessary

that half

- life calculations be based on data for the top 0

- 6 inches (0

- 15 cm). Additionally, the

registrant calculated the half

- lives using data points for intervals at which the parent was not

detected (23 0

- 359 days, 261

- 365 days, and 293 days for the Manitoba, Ontario, and Prince Edward

Island field sites, respectively.

This study does not satisfy the guideline requirement for terrestrial field studies of

dissipation/accumulation in Canada because the fa te of transformation products, detected in the

laboratory studies in concentrations > 10% has not been described and because there is insufficient

data to determine storage stability of zoxamide during storage. Therefore, this study is classified

as suppl ementary information. (MRID 44732126)

Accumulation

Bioconcentration in fish (165

- 4)

-- A bioaccumulation study with Bluegill sunfish ( Lepomis

macrochirus ) was conducted to determine the potential of RH

- 117281 to bioaccumlate in fish

tissue. Exposu re concentrations of 0.5 and 5.0 μg/L were used for the 28

- day bioconcentration

portion of the study which was followed by a 14

- day depuration period.

The rate of uptake in the exposure phase, k 1, 

## were estimated to be 228 + 26 and 180 + 32 μg/kg of

fish per μg/L of water per day at the low and high exposure levels, respectively. A 90 %

steady

- state in the uptake was reached on day 1.4 +

Kinetic bioconcentration factors (BCFKs) were 8.1

- 30 for muscle, 64

- 360 for vicera, and 34

- 180

for whole fish. Steady

- state bioconcentration factors for whole fish were determined to be 136 + 19

at 0.05 μg/L and 95 + 24 at 5.0 μg/L. The depuration constant, k 2 

## , was estimated to be 1.7 + 0.14 and 0.11 and on day 1.2 + 0.22 post

- initiation at the

low and high exposure levels, respectively.

## 34 1.9 + 0.33 per day at the low and high exposure levels, respectively. By day 0.41 + 0.034 following

low exposure, and day 0.37 + 0.065 following high exposure, 50 % of RH

- 117281 had depurated.

The results of this stud y indicated that RH

- 117281 was rapidly absorbed and moderately rapidly

excreted. The kinetic BCF values did not exceed 360 in viscera, 30 in fillets and 180 in whole fish,

but the lipid adjusted BCF values ranged from 464

- 1670 which suggested that RH

- 11728 1 has a

moderate potential to bioaccumulate in fish.

This study is classified as acceptable and satisfies the guideline requirement for bioaccumulation

in fish study.

Spray Drift (201

- 1 and 202

- 1) :

No spray drift

- specific studies were reviewed for this pesticide. Droplet size spectrum (201

- 1)

and drift field evaluation (202

- 1) studies are required since the product may be applied by aerial

and ground spray equipment and due to the concern for potential risk to nontarget plants.

However, to satisfy the se requirements the registrant, in conjunction with other registrants of other

pesticide active ingredients, formed the Spray Drift Task Force (SDTF). The SDTF has

completed and submitted to the Agency its series of studies which are intended to character ize

spray droplet drift potential due to various factors, including application methods, application

equipment, meteorological conditions, crop geometry, and droplet characteristics. In the interim

and for this assessment, the Agency is relying on previou sly submitted spray drift data and the

open literature for off

- target drift rates. The standard assumption used by EFED for ground and

aerial application is that 1 and 5% of the application rate is deposited 100 ft down wind,

respectively. After peer rev iew of the SDTF data is completed, the Agency will determine

whether a reassessment is warranted of the potential risks from the application of this chemical.

## 35 Table A

- 1. Environmental Degradates of Zoxamide

Confirmed

Degradate Lab Results

Max %AR 1 

## Chemical Structure

(Study)

RH

- 150721 38 (hydrolysis, pH 4)

11 (aerobic aquatic,

soil)

11 (aqueous photol)

Benzoic acid, 3,5

- dichloro

- 4

- methyl,

3

- amino

- 3

- methyl

- 2

- oxopentyl ester



## RH

- 24549 31 (hydrolysis, pH 4)

21 (hydrolysis, pH 7)

12 (hydrolysis, pH 9)

28 (aqueous photol)

22 (soil photol)

7 (aerobic soil)

17 (anaerobic soil)

RH

- 141288 22 (hydrolysis, pH 7)

50 (hydrolysis, pH 9)

0.7 (anaerobic soil)

10.5 (fish)

RH

- 129151 25 (hydrolysis, pH 7)

1 

## %AR =% of applied radioactivity.

## 36 16 (hydrolysis, pH 9)

4 (soil photol)

1.6 (aerobic soil)

0.9 (anaerobic soil)

RH

- 139432 42 (aqueous photol)

1 (aerobic soil)

0.5 (anaerobic soil)

RH

- 127450 11 (soil photol)

6 (aerobic soil)

13 (anaerobic soil)

13 (aerobic aquatic, water 

## )

20 (aerobic aquatic, sed. 

## )

17 (fish)

RH

- 163353 16 (aerobic aquatic, water 

## )

7 (aerobic aquatic, sed. 

## )

## 37 RH

- 141452 0.2 (anaerobic soil) No structure reported

Bound

residues 32 (soil photolysis)

39 (aerobic soil)

56 (anaerobic soil)

37 (aerobic aquatic,

sed.) Not applicable

Carbon

Dioxide <1 (aqueous

photolysis)

<1 (soil photolysis)

48 (aerobic soil)

5 (anaerobic soil)

20 (aerobic aquatic) N/A

Volatile

compounds N/A

## 38 APPENDIX B

MODELING DISCUSSION

## 39 AQUATIC EXPOSURE AND DRINKING WATER ASSESSMENT

Uncertainties, Assumptions and Limitations

Input parameters used in Tier I (GENEEC) and Tier II (PRZM/EXAMS) modeling were selecting

using Agency guidance (“ Guidance for Chemistry and Management Practice Input Parameters

for Use in Modeling the Environmental Fate and Transport of” dated August 6, 2000) and EFED

calculated degradation rate constants from review of registrant submitted environmental fate

studies . The abiotic hydrolysis of zoxamide was assumed to be important degradation

mechanism in aquatic metabolism studies. Therefore, in order to avoid double

- counting hydrolysis

in surface water modeling, the aquatic metabolism data were not corrected for abi otic hydrolysis.

Zoxamide is proposed for use on grapes and potatoes throughout the U.S., therefore, two scenarios

were simulated to estimate what the runoff concentrations would be under a range of cropping

systems. EFED selected scenarios in New York f or grapes and Maine for potatoes. Both

scenarios represent EFED standard scenarios developed for use in modeling the respective crops.

Each scenario was developed to approximately represent the 90 th 

## percentile site for runoff

vulnerability in a high usage state with New York representing the third highest acreage state for

grapes and Maine representing the fifth highest acreage state for potatoes. Application timing

was taken from registrant provided information and recent labels.

The standard scenario for potatoes is based on usage patterns in Arastook County, Maine. The soil

is a Conant silt loam (coarse

- loamy, mixed, frigid Aquic Haplorthods) in Major Land Use Area

(MLRA) 143. The Conant silt loam is a very deep, moderately well drained and somewhat poorly

drained soil formed in glacial till. The soil is characterized as a Hydrologic Group C soil. The

standard scenario for grapes is based on usage patterns in Chautauqua County, New York. The

soil is a Hornell silt loam (fine, illitic, acid, mesic A eric Endoaquepts) in MLRA 100. The Hornell

silt loam is a moderately deep, somewhat poorly drained soil formed in till overlying shale or

siltstone. The soil is characterized as a Hydrologic Group D soil.

A major uncertainty in the assessment is the lack of environmental fate data for the transformation

products of zoxamide. In order to address this uncertainty, EFED has conducted the Tier II

modeling on the zoxamide residues (RH

- 150721, RH

- 24549, RH

- 141288, RH

- 129151,

RH

- 139432, RH

- 127450, and RH

- 163353) identified in the fate studies instead of individual

residues. This approach was taken because the environmental fate studies were deficient in

addressing the fate of zoxamide transformation. No data were provided by the registrant assessing

fat e parameters for zoxamide residues, therefore, the half

- lives were calculated on sum of the total

identifiable residues. The Agency has estimated various fate parameters for use in the drinking

water exposure assessment by performing linear regression on the total residues (as employed

through the Sigmaplot

- Regression Wizard) for the Aerobic Aquatic Metabolism, Photolysis,

Anaerobic Soil Metabolism, and Aerobic Soil Metabolism. Although the persistence of

zoxamide residues was estimated from registrant submitted environmental fate data for parent

zoxamide, the mobility of zoxamide residues was estimated using the zoxamide degradate

RH

- 24549 (Benzoic acid, 3,5

- dichloro

- 4

- methyl ). This compound is expected to be an anion

under most environmental conditio ns; hence, it is expected to be highly mobile in soil and

## 40 aquatic environments Physical chemistry parameters were estimated for RH

- 24549 (Estimation

Programs Interface (EPI), Version 3.04, 1999) which estimates fate parameter using published

equations. More detail on EPI estimation techniques may be found at

http://syrres.com/interkow/epi.htm.and degradation rate constants were estimated by performing

linear regression on the total residues (Sigmaplot

- Regression Wizard, Version 6.00, 2000) from

several fate studies.

The index reservoir represents potential drinking water exposure from a specific area (Mississippi)

with specific cropping patterns, weather, soils, and other factors (use of an index reservoir for

areas with different climates, crops, pe sticides used, sources of water, and hydrogeology creates

uncertainties). If a community derives its drinking water from a large river, then the estimated

exposure would likely be higher than the actual exposure. Conversely, a community that derives

its drinking water from smaller bodies of water with minimal outflow would likely get higher

drinking water exposure that estimated using the index reservoir. Areas with a less humid climate

that use a similar reservoir and cropping patterns would likely get less pesticides in their drinking

water than predicted levels. A single steady flow has been used to represent the flow through the

reservoir. Discharge from the reservoir also removes chemical from it so this assumption will

underestimate removal from the reservoir during wet periods and overestimates removal during

dry periods. This assumption can both underestimate or overestimate the concentration in the

pond depending upon the annual precipitation pattern at the site. The index reservoir scenario

uses the characteristic of a single soil to represent the soil in the basin. In fact, soils can vary

substantially across even small areas, and thus, this variation is not reflected in these simulations.

The index reservoir scenario does not consider t ile drainage. Areas that are prone to substantial

runoff are often tile drained. This may underestimate exposure, particularly on a chronic basis.

EXAMS is unable to easily model spring and fall turnover which results in complete mixing of the

chemical through the water column at these times. Because of this inability, Shipman City Lake

has been simulated without stratification. There is data to suggest that Shipman City Lake does

indeed stratify in the deepest parts of the lake at least in some years. This may result in both over

and underestimation of the concentration in drinking water depending upon the time of the year

and the depth the drinking water intake is drawing from.

PRZM/EXAMS is a field

- scale model which treats watersheds as la rge fields. It assumes that the

entire area of the watershed is planted with the crop of interest (i.e., 100% crop coverage). This

assumption may not hold for areas larger than a few hectares, such as watersheds containing

drinking water reservoirs. The refore, pesticide concentrations (peak and/or long

- term average)

were estimated with PRZM/EXAMS (the index reservoir modification changes the surface water

body parameters used in EXAMS) and the model results from PRZM/EXAMS were adjusted

by a factor tha t represents the maximum percent crop area found for the crop or crops being

evaluated. Percent crop areas (PCAs) were derived on a watershed basis with GIS tools using 1992

Census of Agriculture data and 8

- digit Hydrologic Unit Code (HUC) coverage for the coterminous

United States. The maximum PCA derived from this project was selected to represent the

modeled crop or crops. The PCA assumes the distribution of the crops within a county is uniform

and homogeneous throughout the county area. Distance betwe en the treated fields and the water

body is not addressed.

## 41 The PCA is a watershed

- based modification. Implicit in its application is the assumption that

currently

- used field

- scale models reflect basin

- scale processes consistently for all pesticides and

u ses. In other words, we assume that the large field simulated by the coupled PRZM and EXAMS

models is a reasonable approximation of pesticide fate and transport within a watershed that

contains a drinking water reservoir. If the models fail to capture pe rtinent basin

- scale fate and

transport processes consistently for all pesticides and all uses, the application of a factor that

reduces the estimated concentrations predicted by modeling could, in some instances, result in

inadvertently passing a chemical through the screen that may actually pose a risk. Some

preliminary assessments made in the development of the PCA suggest that PRZM/EXAMS may

not be realistically capturing basin

- scale processes for all pesticides or for all uses. A preliminary

survey of water assessments which compared screening model estimates to readily available

monitoring data suggest uneven model results. In some instances, the screening model estimates

are more than an order of magnitude greater than the highest concentrations rep orted in available

monitoring data; in other instances, the model estimates are less than monitoring concentrations.

Because of these concerns, the SAP recommended using the PCA only for “major” crops in the

South. For other crops, development of PCAs wi ll depend on the availability of relevant

monitoring data that could be used to evaluate the result of the PCA adjustment.



# Water Resources Summary

Because zoxamide is not included among regulated or unregulated chemicals required as analytes

in testing of public drinking water supplies, drinking

- water monitoring results are not available.

Therefore, the aquatic and drinking water exposure assessment s are based on modeling

predictions.

Ecological Assessment

Tier I Modeling

-- Input parameters for GENEEC (Table B

- 1) were selected according to current

EFED guidance (“ Guidance for Chemistry and Management Practice Input Parameters for Use in

Modeling t he Environmental Fate and Transport of Pesticides” dated August 6, 2000).

GENEEC modeling estimates that aerially and ground

- applied zoxamide are not expected to

exceed, respectively, 16.4 and 18.4 μg/L for the annual peak concentration (acute) and 4.2 a nd

4.7 μg/L for the 56 day average concentration (chronic), respectively for the grape and potato uses

(Table B

- 2).

Table B

- 1. Input Parameters for Zoxamide for GENEEC (Version 1.2) used in the

Aquatic Exposure Assessment

Parameter

(units) Input Value Source of Information/

Reference

Application rate

(pounds a.i. acre

- 1 ) 0.2 Product label

Number of applications 8 Product label

## 42 Table B

- 1. Input Parameters for Zoxamide for GENEEC (Version 1.2) used in the

Aquatic Exposure Assessment

Parameter

(units) Input Value Source of Information/

Reference

Interval between applications (days) 5 (potatoes) 7 (grapes) Product label

Partition Coefficient

K

d or K

oc (mL g

o.c. - 1 or L kg

o.c. - 1 ) Koc = 815 L/kg MRID 44731916

Aerobic Soil Metabolism (t 1/2 in days) 38.7 days (UB 90 th % of 37.5 and 38.1

days) MRID 44731912

MRID 44731913

Wetted in? No Product label

Depth of incorporation (inches) 0 Product label

Method of application aerial and ground Product label

Solubility in water (mg/L) 0.68 MRID 44731803

Aerobic Aquatic Metabolism (t 1/2 in

days) 11.8 days (UB 90 th % of 3.6 and 7.6 days) MRID 44700002

Hydrolysis (pH 7) (t 1/2 in days) 0 days MRID 44731908

Aquatic Photolysis (pH 7) (t 1/2 in days) 14 days (dark corrected value) MRID 44731911



## Table B

- 2. Estimated Environmental Concentrations (μg/L) of Zoxamide in Surface Water

(GENEEC Tier 1 modeling) used for Aquatic Exposure Assessment.

Application Regime Crop Peak 4 day 21 day 56 day

Multiple Aerial Potatoes 18.4 16.6 9.8 4.7

Multiple Ground Potatoes 17.6 15.8 9.4 4.5

Multiple Aerial Grapes 16.4 14.8 8.7 4.2

Multiple Ground Grapes 15.8 14.2 8.4 4.0



## GENEEC modeling was performed to estimate parent equivalent concentrations of zoxamide

residues (zoxamide + degradation products). The input for modeling zoxamide residues is in

Table B

- 3. Tier I modeling estimates that zoxamide residues (zoxamide + degradation products)

which are aerially and ground

- applied are not expected to exceed, respectively , 61.1 and 57.0

μg/L for the annual peak concentration (acute) and 48.3 and 45.1 μg/L for the 56 day average

concentration (chronic), respectively for the grape and potatoes (Table B

- 4).

Table B

- 3. Input Parameters for Total Zoxamide Residues for GENEEC (Version 1.2)

used in the Aquatic Exposure Assessment

## 43 Parameter

(units) Input Value Source of Information/

Reference

Application rate

(pounds a.i. acre

- 1 ) 0.2 Product label

Number of applications 8 Product label

Interval between applications (days) 5 (potatoes) 7 (grapes) Product label

Partition Coefficient

K

d or K

oc (mL g

o.c. - 1 or L kg

o.c. - 1 ) Koc = 64.2 L/kg EPI

Aerobic Soil Metabolism (t 1/2 in days) 61.8 days (UB 90 th % of 53.7 and 45.9

days) Estimated from

MRID 44731912

MRID 44731913

Wetted in? No Product label

Depth of incorporation (inches) 0 Product label

Method of application aerial and ground Product label

Solubility in water (mg/L) 27.9 EPI

Aerobic Aquatic Metabolism (t 1/2 in

days) 85.4 days (UB 90 th % of 90, 73.7, 58.7 and

77 days) Estimated from

MRID 44700002

Hydrolysis (pH 7) (t 1/2 in days) 0 days Estimated from

MRID 44731908

Aquatic Photolysis (pH 7) (t 1/2 in days) 0 days Estimated from

MRID 44731911



## Table B

- 4. Estimated Environmental Concentrations (μg/L) of Total Zoxamide Residues in

Surface Water (GENEEC Tier 1 modeling) used for Aquatic Exposure Assessment.

Application Regime Crop Peak 4 day 21 day 56 day

Multiple Aerial Potatoes 57.0 56.2 52.1 45.1

Multiple Ground Potatoes 56.3 55.5 51.5 44.5

Multiple Aerial Grapes 61.1 60.3 55.9 48.3

Multiple Ground Grapes 60.4 59.6 55.2 47.8



## Tier II Modeling

Standard pond scenario modeling for EECs

-- 

## Tier II (PRZM/EXAMS) was performed for

zoxamide because Tier I results exceeded certain aquatic exposure levels. In performing the Tier

II assessment, several factors were considered in choosing the modeling scenario to represent an

upper end (90 th 

## percentile) runoff site. These factors included maximum application rate, number

of applications, interval between applications, irrigati on system, and the vulnerability of the soil in

the use area. EFED standard scenarios were used for both grape and potato scenarios (for both

## 44 standard pond and Index Reservoir). Input parameters for PRZM/EXAMS modeling for aquatic

exposure (Tables B

- 5 an d B

- 6) were selected according to current EFED guidance.

Tier II surface water modeling for aquatic exposure assessment using the standard pond predicts

the 1 in 10 year peak (acute) concentration of parent zoxamide on grapes is not likely to exceed 7.5

μ g/L and on potatoes is not likely to exceed 2.3 μg/L. The 1 in 10 year 4 day average

concentration of parent zoxamide residues on grapes is not likely to exceed 4.3 μg/L and on

potatoes is not likely to exceed 1.2 μg/L. The 1 in 10 year 21 day average co ncentration of parent

zoxamide residues on grapes is not likely to exceed 2.1 μg/L and on potatoes is not likely to exceed

0.6 μg/L. The 1 in 10 year 60 day average concentration of parent zoxamide residues on grapes is

not likely to exceed 1.1 μg/L and o n potatoes is not likely to exceed 0.4 μg/L. Results of Tier II

modeling of zoxamide for Aquatic exposure are presented in Table B

- 7.

## 45 Table B

- 5. Input Parameters for Zoxamide for PRZM (Version 3.12) for Aquatic

Exposure Assessment.

Variable Description Variable (Units) Input Value Source of

Info/Reference

Application date(s) (day/mo/yr) APD, APM, IAPYR

(day/mo/yr) 8 times per year

5 day minimum interval Product label or

location

- specific

Incorporation depth DEPI (cm) 0 Product label

Application rate TAPP

(kg a.i. ha

- 1 ) 0.22 Product label

Application efficiency APPEFF

(decimal) 0.95 Spray Drift Task Force

Data

Spray drift fraction: For aquatic ecological

exposure assessment, use 0.05 for aerial spray;

0.01 for ground spray. For drinking water

assessment, use 0.16 for aerial 0.064 for ground

spray. DRFT

(decimal) 0.05 or 0.01 for Eco

0.16 or 0.064 for DW Spray Drift Task Force

Data

Foliar extraction FEXTRA

(frac./cm rain) 0.5 is the default unless field

data is available Default or field data

Decay rate on foliage PLDKRT

(day

- 1 ) 0.0 is the default unless field

data is available Default or field data

Volatilization rate from foliage PLVKRT

(day

- 1 ) 0.0 is the default unless field

data is available Default or field data

Plant uptake factor UPTKF

(frac. of evap) 0.0 is the default unless field

data is available Default or field data

Dissolved phase pesticide decay rate in surface

horizon

(aerobic soil metabolism) DWRATE (surface)

(day

- 1 ) T 1/2 =38.7 days (UB 90 th %

of 37.5 and 38.1 days)

Rate constant = 0.01791/day MRID 44731912

Adsorbed phase pesticide decay rate in surface

horizon

(aerobic soil metabolism) DSRATE (surface)

(day

- 1 ) T 1/2 =38.7 days (UB 90 th %

of 37.5 and 38.1 days)

Rate constant = 0.01791/day MRID 44731912

Dissolved phase pesticide decay rate in

subsequent subsurface horizons (aerobic or

anaerobic soil metabolism) DWRATE (subsurface

horizons) (day

- 1 ) T 1/2 =38.7 days (UB 90 th %

of 37.5 and 38.1 days)

Rate constant = 0.01791/day MRID 44731912

Adsorbed phase pesticide decay rate in

subsequent subsurface horizons (aerobic or

anaerobic soil metabolism) DSRATE (subsurface

horizons) (day

- 1 ) T 1/2 =38.7 days (UB 90 th %

of 37.5 and 38.1 days)

Rate constant = 0.01791/day MRID 44731912

Pesticide partition or distribution coefficients for

each horizon

(Leaching/Adsorption/Desorption) Koc (slope of regression

from registrant submitted

data) 1345 mL g

- 1 MRID 44731916



## Table B

- 6. Input Parameters for Zoxamide.chm Files Used in EXAMS (version 2.97.5 ) for

Aquatic Exposure Assessment.

## 46 Variable Description Variable (Units) Input Value Source of

Info/Reference

Henry's law constant HENRY

(atm

- m 3 mole

- 1 ) <6.59 x 10

- 3 Pa/mol.m 3 From registrant or

product chemistry

Bacterial biolysis in water column

(aerobic aquatic metabolism) KBACW

(cfu/mL)

- 1 hour

- 1 T 1/2 =11.8 days (UB 90 th % of

3.6 and 7.6 days)

Rate constant = 0.00245/hr MRID 44770002

Bacterial biolysis in benthic sediment

(anaerobic aquatic or aerobic aquatic

metabolism) KBACS 1

(cfu/mL)

- 1 hour

- 1 0 MRID 44770002

Direct photolysis (aqueous photolysis) KDP

(hour

- 1 ) T 1/2 = 14 days (dark corrected

value)

Rate constant =0.0021/hr MRID 44731911

Base hydrolysis KBH (mole

- 1 hour

- 1 ) 0 MRID 44731908

Neutral hydrolysis KNH (mole

- 1 hour

- 1 ) 0 MRID 44731908

Acid hydrolysis KAH (mole

- 1 hour

- 1 ) 0 MRID 44731908

Partition coefficient for sediments

(Leaching/Adsorption/Desorption)

need Kd from soil closest to crop scenario Koc (mL g

- 1 or L kg

- 1 ) 1345 mL g

- 1 MRID 44731916

Molecular weight MWT (g mole

- 1 ) 336.1 Calculated

Aqueous solubility (Multiply water solubility by

10) SOL (mg L

- 1 ) = 6.8 MRID 44731803

Vapor pressure VAPR (torr) <1.0 x 10

- 7 torr @ 25 **°** C MRID 44731803

Sediment bacteria temperature coefficient QTBAS 2 Standard value

Water bacteria temperature coefficient QTBAW 2 Standard value



## Table B

- 7. PRZM

- EXAMS Predicted Zoxamide Concentrations in the Aquatic (Pond)

Scenario

Simulation Scenarios Concentration (ug/L)

1 in 10 Year Estimate

Crop and Location Scenario Peak 96 Hour 21 Day 60 Day

Potatoes, Arastook Co.,

ME Aquatic(Pond) Scenario 2.3 1.2 0.6 0.4

Grapes Chautauqua Co,

NY Aquatic (Pond) Scenario 7.5 4.3 2.1 1.1



## Index reservoir and percent crop area

## 47 Tier II drinking water assessment for the use of zoxamide on grapes and potatoes was performed

using the PRZM/EXAMS modeling with a reservoir index (IR) and a percent crop area (PCA)

scenario and a standard pond scenario. As per the EFED guidance document for using the percent

area crop for Tier II modeling, the default PCA of 0.87 was used because there are no peer

reviewed PCAs for these crops. According to the label ( DP Barcode D259459), zoxamide can be

applied to grapes and potatoes at a maximum appli cation rate of 0.2 lb. a.i./acre with eight

applications at five

- or seven

- day intervals per season. Input parameters for PRZM/EXAMS

modeling for drinking water exposure (Tables B

- 8 and B

- 9) were selected according to current

EFED guidance.

Tier II ( PRZM

- EXAMS) surface water modeling for zoxamide (parent only) using the index

reservoir with the percent cropped area (PCA=0.87 for grapes and potatoes) predicts the 1 in 10

year peak (acute) concentration of zoxamide residues on grapes is not likely to excee d 16.9 μg/L

and on potatoes is not likely to exceed 4.9 μg/L. The 1 in 10 year annual average concentration

(non

- cancer chronic) of zoxamide residues on grapes is not likely to exceed 0.9 μg/L and on

potatoes is not likely to exceed 0.2 μg/L. The 36 year a nnual average concentration (cancer

chronic) of zoxamide residues on grapes is not likely to exceed 0.5 μg/L and on potatoes is not

likely to exceed 0.2 μg/L (Table B

- 10).

## 48 Table B

- 8. Input Parameters for Zoxamide for PRZM (Version 3.12) for Index Reservoir

and PCA.

Variable Description Variable (Units) Input Value Source of

Info/Reference

Application date(s) (day/mo/yr) APD, APM, IAPYR

(day/mo/yr) 8 times per year

5 day minimum interval Product label or

location

- specific

Incorporation depth DEPI (cm) 0 Product label

Application rate TAPP

(kg a.i. ha

- 1 ) 0.22 Product label

Application efficiency APPEFF

(decimal) 0.95 Spray Drift Task Force

Data

Spray drift fraction: For aquatic ecological

exposure assessment, use 0.05 for aerial spray;

0.01 for ground spray. For drinking water

assessment, use 0.16 for aerial 0.064 for ground

spray. DRFT

(decimal) 0.05 or 0.01 for Eco

0.16 or 0.064 for DW Spray Drift Task Force

Data

Foliar extraction FEXTRA

(frac./cm rain) 0.5 is the default unless field

data is available Default or field data

Decay rate on foliage PLDKRT

(day

- 1 ) 0.0 is the default unless field

data is available Default or field data

Volatilization rate from foliage PLVKRT

(day

- 1 ) 0.0 is the default unless field

data is available Default or field data

Plant uptake factor UPTKF

(frac. of evap) 0.0 is the default unless field

data is available Default or field data

Dissolved phase pesticide decay rate in surface

horizon

(aerobic soil metabolism) DWRATE (surface)

(day

- 1 ) T 1/2 =38.7 days (UB 90 th %

of 37.5 and 38.1 days)

Rate constant = 0.01791/day MRID 44731912

Adsorbed phase pesticide decay rate in surface

horizon

(aerobic soil metabolism) DSRATE (surface)

(day

- 1 ) T 1/2 =38.7 days (UB 90 th %

of 37.5 and 38.1 days)

Rate constant = 0.01791/day MRID 44731912

Dissolved phase pesticide decay rate in

subsequent subsurface horizons (aerobic or

anaerobic soil metabolism) DWRATE (subsurface

horizons) (day

- 1 ) T 1/2 =38.7 days (UB 90 th %

of 37.5 and 38.1 days)

Rate constant = 0.01791/day MRID 44731912

Adsorbed phase pesticide decay rate in

subsequent subsurface horizons (aerobic or

anaerobic soil metabolism) DSRATE (subsurface

horizons) (day

- 1 ) T 1/2 =38.7 days (UB 90 th %

of 37.5 and 38.1 days)

Rate constant = 0.01791/day MRID 44731912

Pesticide partition or distribution coefficients for

each horizon

(Leaching/Adsorption/Desorption) Koc (slope of regression

from registrant submitted

data) 1345 mL g

- 1 MRID 44731916

## 49 Table B

- 9. Input Parameters for Zoxamide.chm Files Used in EXAMS (Version 2.97. 5) for

Index Reservoir and PCA.

Variable Description Variable (Units) Input Value Source of

Info/Refere

nce

Henry's law constant HENRY

(atm

- m 3 mole

- 1 ) <6.59 x 10

- 3 Pa/mol.m 3 From registrant or

product chemistry

Bacterial biolysis in water column

(aerobic aquatic metabolism) KBACW

(cfu/mL)

- 1 hour

- 1 T 1/2 =11.8 days (UB 90 th % of

3.6 and 7.6 days)

Rate constant = 0.00245/hr MRID 44770002

Bacterial biolysis in benthic sediment

(anaerobic aquatic or aerobic aquatic

metabolism) KBACS 1

(cfu/mL)

- 1 hour

- 1 0 MRID 44770002

Direct photolysis (aqueous photolysis) KDP

(hour

- 1 ) T 1/2 = 14 days (dark corrected

value)

Rate constant =0.0021/hr MRID 44731911

Base hydrolysis KBH (mole

- 1 hour

- 1 ) 0 MRID 44731908

Neutral hydrolysis KNH (mole

- 1 hour

- 1 ) 0 MRID 44731908

Acid hydrolysis KAH (mole

- 1 hour

- 1 ) 0 MRID 44731908

Partition coefficient for sediments

(Leaching/Adsorption/Desorption)

need Kd from soil closest to crop scenario KPS (mL g

- 1 or L kg

- 1 ) 1345 mL g

- 1 MRID 44731916

Molecular weight MWT (g mole

- 1 ) 336.1 Calculated

Aqueous solubility (Multiply water solubility by

10) SOL (mg L

- 1 ) = 0.800 6.8 MRID 44731803

Vapor pressure VAPR (torr) <1.0 x 10

- 7 torr @ 25 **°** C MRID 44731803

Sediment bacteria temperature coefficient QTBAS 2 Standard value

Water bacteria temperature coefficient QTBAW 2 Standard value

1

- 

## Note that hydrolysis set to 0. Hydrolysis accounted for in aerobic aquatic metabolism and

anaerobic soil metabolism input parameters. An alternate scenario was run with hydrolysis

adjusted metabolism rate constants resulting in similar EECs.

## 50 Table B

- 10. PRZM

- EXAMS Predicted Zoxamide Concentrations in the Index Reservior

Simulation Scenarios Concentration (μg/L)

1 in 10 year

Mean of

Annual

Means Crop and

Location Scenario

Peak 96 Hour 21 Day 60 Day 90 Day Annual

Mean

Potatoes,

Arastook Co.,

ME Index Reservoir 5.6 3.4 1.8 1.1 0.8 0.2 0.2

Index Reservoir

w/PCA (0.87) 4.9 3.0 1.6 1.0 0.7 0.2 0.2

Grapes

Chautauqua

Co, NY Index Reservoir 19.5 13.4 7.1 3.5 2.7 1.0 0.6

Index Reservoir

w/PCA (0.87) 16.9 11.7 6.2 3.0 2.3 0.9 0.5



## Total Zoxamide Residues

EFED conducted a Tier II drinking water assessment for zoxamide (RH 117281) and its

transformation products. Input parameters for PRZM/EXAMS modeling for drinking water

exposure (Tables B

- 11 and B

- 12) were selected according to current EFED guidance. Tier II

surface water modeling using the index reservoir with the percent cropped area (PCA=0.87 for

grapes and potatoes ) predicts the 1 in 10 year peak (acute) concentration of zoxamide residues on

grapes is not likely to exceed 77.7 μg/L and on potatoes is not likely to exceed 20.9 μg/L. The 1 in

10 year annual average concentration (non

- cancer chronic) of zoxamide resid ues on grapes is not

likely to exceed 21.8 μg/L and on potatoes is not likely to exceed 6.2 μg/L. The 36 year annual

average concentration (cancer chronic) of zoxamide residues on grapes is not likely to exceed 12.4

μg/L and on potatoes is not likely to e xceed 4.1 μg/L. Tier II assessment results for total residues

are presented in Table B

- 13.

## 51 Table B

- 11: Input Parameters for Radioactivity Summary for PRZM (Version 3.12) for

Total Zoxamide Residues

Variable Description Variable (Units) Input Value Source of

Info/Reference

Application date(s) (day/mo/yr) APD, APM, IAPYR

(day/mo/yr) 8 times per year

5 day minimum interval Product label or

location

- specific

Incorporation depth DEPI (cm) 0 Product label

Application rate TAPP

(kg a.i. ha

- 1 ) 0.22 Product label

Application efficiency APPEFF

(decimal) 0.95 Spray Drift Task

Force Data

Spray drift fraction: For aquatic ecological

exposure assessment, use 0.05 for aerial spray;

0.01 for ground spray. For drinking water

assessment, use 0.16 for aerial 0.064 for ground

spray. DRFT

(decimal) 0.05 or 0.01 for Eco

0.16 or 0.064 for DW Spray Drift Task

Force Data

Foliar extraction FEXTRA

(frac./cm rain) 0.5 is the default unless field

data is available Default or field data

Decay rate on foliage PLDKRT

(day

- 1 ) 0.0 is the default unless field

data is available Default or field data

Volatilization rate from foliage PLVKRT

(day

- 1 ) 0.0 is the default unless field

data is available Default or field data

Plant uptake factor UPTKF

(frac. of evap) 0.0 is the default unless field

data is available Default or field data

Dissolved phase pesticide decay rate in surface

horizon

(aerobic soil metabolism) DWRATE (surface)

(day

- 1 ) T 1/2 =61.8 days (UB 90 th %

of 53.7 and 45.9 days)

Rate constant = 0.011/day Estimated from

MRID 44731912

Adsorbed phase pesticide decay rate in surface

horizon

(aerobic soil metabolism) DSRATE (surface)

(day

- 1 ) T 1/2 =61.8 days (UB 90 th %

of 53.7 and 45.9 days)

Rate constant = 0.011/day Estimated from

MRID 44731912

Dissolved phase pesticide decay rate in

subsequent subsurface horizons (aerobic or

anaerobic soil metabolism) DWRATE (subsurface

horizons) (day

- 1 ) T 1/2 =61.8 days (UB 90 th %

of 53.7 and 45.9 days)

Rate constant = 0.011/day Estimated from

MRID 44731912

Adsorbed phase pesticide decay rate in

subsequent subsurface horizons (aerobic or

anaerobic soil metabolism) DSRATE (subsurface

horizons) (day

- 1 ) T 1/2 =61.8 days (UB 90 th %

of 53.7 and 45.9 days)

Rate constant = 0.011/day Estimated from

MRID 44731912

Pesticide partition or distribution coefficients for

each horizon

(Leaching/Adsorption/Desorption) Koc (cm 3 gm - 1 or mL g

- 1 or L

kg

- 1 ) 64.2 mL g

- 1 EPI

## 52 Table B

- 12: Input Parameters for Radioactivity Summary for EXAM (Version 2.97. 5) for

Total Zoxamide Residues

Variable Description Variable (Units) Input Value Source of

Info/Reference

Henry's law constant HENRY

(atm

- m 3 mole

- 1 ) 1.52 x 10 - 6 EPI

Bacterial biolysis in water column

(aerobic aquatic metabolism) KBACW

(cfu/mL)

- 1 hour

- 1 3.4 E

- 4/hr Estimated from

MRID 44770002

Bacterial biolysis in benthic sediment

(anaerobic aquatic or aerobic aquatic

metabolism) KBACS 1

(cfu/mL)

- 1 hour

- 1 0 Estimated from

MRID 44770002

Direct photolysis (aqueous photolysis) KDP

(hour

- 1 ) 4.6 E

- 5/hr Estimated from

MRID 44731911

Base hydrolysis 1 KBH (mole

- 1 hour

- 1 ) 0 MRID 44731908

Neutral hydrolysis 1 KNH (mole

- 1 hour

- 1 ) 0 MRID 44731908

Acid hydrolysis 1 KAH (mole

- 1 hour

- 1 ) 0 MRID 44731908

Partition coefficient for sediments

(Leaching/Adsorption/Desorption)

need Kd from soil closest to crop scenario KPS (mL g

- 1 or L kg

- 1 ) 64.2 mL g

- 1 EPI

Molecular weight MWT (g mole

- 1 ) 205.4 EPI

Aqueous solubility (Multiply water solubility by

10) SOL (mg L

- 1 ) = 0.27.9 279 EPI

Vapor pressure VAPR (torr) 1.6 x 10 - 4 torr @ 25 **°** C EPI

Sediment bacteria temperature coefficient QTBAS 2 Standard value

Water bacteria temperature coefficient QTBAW 2 Standard value

1

- 

## Note that hydrolysis set to 0. Hydrolysis accounted for in aerobic aquatic metabolism and

anaerobic soil metabolism input parameters. An alternate scenario was run with hydrolysis

adjusted metabolism rate constants resulting in similar EECs.

## 53 Table B

- 13: PRZM

- EXAMS Predicted Total Zoxamide Residue Concentrations in the

Index Reservoir

Simulation Scenarios Concentration (μg/L)

1 in 10 Year

Mean

of Annual

Values Crop and

Location Scenario

Peak 96 Hour 21 Day 60 Day 90 Day Yearly

Potatoes,

Arastook Co.,

ME Index Reservoir 24.0 23.4 22.0 19.4 17.1 7.2 4.7

Index Reservoir

w/PCA (0.87) 20.9 20.3 19.2 16.9 14.9 6.2 4.1

Grapes

Chautauqua

Co, NY Index Reservoir 89.3 86.6 80.9 68.5 59.8 25.1 14.3

Index Reservoir

w/PCA (0.87) 77.7 75.3 70.4 59.6 52.1 21.8 12.4



## Ground Water Assessment

Ground water EECs were modeled using SCI

- GROW, a screening groundwater regression model

developed using data from prospective groundwater studies submitted to the OPP in support of

registration. SCI

- GROW provides a reasonable high

- end estimate of ground water

concentrations of pesticides on soils that a re known to be vulnerable to pesticide leaching (high

sand content with shallow depth to groundwater).

Table B

- 14 provides the environmental fate inputs and ground water concentration for the

application rate and interval listed above for parent zoxamide. Table B

- 15 provides the

environmental fate inputs and ground water concentration for the application rate and interval

listed above for total zoxamide residues. The estimated EEC is considered representative of both

a peak and long

- term average concentr ation because of the inherent transport nature of ground

water (generally slow movement from source of contamination both laterally and horizontally).

The acute and chronic zoxamide and zoxamide residue concentrations are not expected to exceed

0.061 μ g/L and 2.07 μ g/L , respectively.

Table B

- 14. SCI

- GROW Estimated Ground Water Concentrations for Parent Zoxamide

(μg/L)

Agricultural Setting Fate and Transport Inputs Concentration in Ground Water

(μg/L)

Aerobic Soil Metabolism (T 1/2 ) Soil Adsorption Coefficient (L/Kg)

Potatoes 37.8 days 1294 ml/g 0.061

Grapes 37.8 days 1294 ml/g 0.061

## 54 Table B

- 15. SCI

- GROW Estimated Ground Water Concentrations for Total Zoxamide

Residues (μg/L)

Agricultural Setting Fate and Transport Inputs Concentration in Ground Water

(μg/L)

Aerobic Soil Metabolism (T 1/2 ) Soil Adsorption Coefficient (L/Kg)

Potatoes 61.8 days 64.2 ml/g 2.07

Grapes 61.8 days 64.2 ml/g 2.07

## 55 Zoxamide Aerial Application to Potatoes

– Input Values and EECs for GENEEC.

-------------------------------------------------------------------- RATE (#/AC) APPLICATIONS SOIL SOLUBILITY % SPRAY INCORP

ONE(MULT) NO.

- INTERVAL KOC (PPB) DRIFT DEPTH(IN)

-------------------------------------------------------------------- .200( 1.194) 8 5 815.0 680.0 5.0 .0

FIELD AND STANDARD POND HALFLIFE VALUES (DAYS)

METABOLIC DAYS UNTIL HYDROLYSIS PHOTOLYSIS METABOLIC COMBINED

(FIELD) RAIN/RUNOFF (POND) (POND

- EFF) (POND) (POND)

--------------------------------------------------------------------

38.70 0 N/A 14.00

- 1717.80 11.80 11.72

GENERIC EECs (IN PPB)

--- ----------------------------------------------------- PEAK AVERAGE 4 AVERAGE 21 AVERAGE 56

GEEC DAY GEEC DAY GEEC DAY GEEC

--------------------------------------------------------

18.37 16. 59 9.82 4.69

Zoxamide Aerial Application to Grapes

- Input Values and EECs for GENEEC.

-------------------------------------------------------------------- RATE (#/AC) APPLICATIONS SOIL SOLUBILITY % SPRAY INCORP

ONE(MULT) NO.

- INTERVAL KOC (PPB) DRIFT DEPTH(IN)

-------------------------------------------------------------------- .200( 1.075) 8 7 815.0 680.0 5.0 .0

FIELD AND STANDARD POND HALFLIFE VALUES (DAYS)

-------------------------------------------------------------------- METABOLIC DAYS UNTIL HYDROLYSIS PHOTOLYSIS METABOLIC COMBINED

(FIELD) RAIN/RUNOFF (POND) (POND

- EFF) (POND) (POND)

----------------------------- ---------------------------------------

38.70 0 N/A 14.00

- 1717.80 11.80 11.72

GENERIC EECs (IN PPB)

-------------------------------------------------------- PEAK AVERAGE 4 AVERAGE 21 AVERAGE 56

GEEC DAY GEEC DAY GEEC DAY GEEC

--------------------------------------------------------

16.35 14.76 8.73 4.17

Zoxamide Ground Application to Potatoes

- Input Values and EECs for GENEEC.

---- ---------------------------------------------------------------- RATE (#/AC) APPLICATIONS SOIL SOLUBILITY % SPRAY INCORP

ONE(MULT) NO.

- INTERVAL KOC (PPB) DRIFT DEPTH(IN)

----------------------------------------------- --------------------- .200( 1.194) 8 5 815.0 680.0 1.0 .0

FIELD AND STANDARD POND HALFLIFE VALUES (DAYS)

-------------------------------------------------------------------- METABOLIC DAYS UNTIL HYDROLYSIS PHOTOLYSIS METABOLIC COMBINED

(FIELD) RAIN/RUNOFF (POND) (POND

- EFF) (POND) (POND)

--------------------------------------------------------------------

38.70 0 N/A 14. 00

- 1717.80 11.80 11.72

GENERIC EECs (IN PPB)

-------------------------------------------------------- PEAK AVERAGE 4 AVERAGE 21 AVERAGE 56

GEEC DAY GEEC DAY GEEC DAY GEEC

----------------- ---------------------------------------

17.59 15.82 9.35 4.47

Zoxamide Ground Application to Grapes

- Input Values and EECs for GENEEC



## .

--------------------------------------------------------------------

## 56 RATE (#/AC ) APPLICATIONS SOIL SOLUBILITY % SPRAY INCORP

ONE(MULT) NO.

- INTERVAL KOC (PPB) DRIFT DEPTH(IN)

-------------------------------------------------------------------- .200( 1.075) 8 7 815.0 680.0 1 .0 .0

FIELD AND STANDARD POND HALFLIFE VALUES (DAYS)

-------------------------------------------------------------------- METABOLIC DAYS UNTIL HYDROLYSIS PHOTOLYSIS METABOLIC COMBINED

(FIELD) RAIN/RUNOFF (POND) (P OND

- EFF) (POND) (POND)

--------------------------------------------------------------------

38.70 0 N/A 14.00

- 1717.80 11.80 11.72

GENERIC EECs (IN PPB)

------------------------------------------------------ -- PEAK AVERAGE 4 AVERAGE 21 AVERAGE 56

GEEC DAY GEEC DAY GEEC DAY GEEC

--------------------------------------------------------

15.79 14.20 8.40 4.01

Zoxamide Residues Aerial Application to Grapes

– Input Values and EECs for GENEEC

RUN No. 1 FOR Zoxamide + Degradates INPUT VALUES

--------------------------------------------------------------------

RATE (#/AC) APPLICATIONS SOIL SOLUBILITY % SPRAY INCOR P

ONE(MULT) NO.

- INTERVAL KOC (PPM) DRIFT DEPTH(IN)

--------------------------------------------------------------------

.200( 1.326) 8 5 64.2 27.9 5.0 .0

FIELD AND STANDARD POND HALFLIFE VALU ES (DAYS)

--------------------------------------------------------------------

METABOLIC DAYS UNTIL HYDROLYSIS PHOTOLYSIS METABOLIC COMBINED

(FIELD) RAIN/RUNOFF (POND) (POND

- EFF) (POND) (POND)

-------------------------- ------------------------------------------

61.80 0 N/A .00

- .00 85.40 85.40

GENERIC EECs (IN PPB)

--------------------------------------------------------

PEAK AVERAGE 4 AVERAGE 21 AVERAGE 56

GEEC DAY GEEC DAY GEEC DAY GEEC

--------------------------------------------------------

61.06 60.26 55.89 48.30

Zoxamide Residues Gro und Application to Grapes

– Input Values and EECs for GENEEC

RUN No. 2 FOR Zoxamide + Degradates INPUT VALUES

--------------------------------------------------------------------

RATE (#/AC) APPLICATIONS SOIL SOLUBILITY % SPRAY INCORP

ONE(MULT) NO.

- INTERVAL KOC (PPM) DRIFT DEPTH(IN)

--------------------------------------------------------------------

.200( 1.326) 8 5 64.2 27.9 1.0 .0

FIELD AND STANDARD POND HALFLIFE VALUES (DAYS)

--------------------------------------------------------------------

METABOLIC DAYS UNTIL HYDROLYSIS PHOTOLYSIS METABOLIC COMBINED

(FIELD) RAIN/RUNOFF (POND) (POND

- EFF) (POND) (POND)

---------------------------- ----------------------------------------

61.80 0 N/A .00

- .00 85.40 85.40

GENERIC EECs (IN PPB)

--------------------------------------------------------

PEAK AVERAGE 4 AVERAGE 21 AVERAGE 56

## 57 GEEC DAY GEEC DAY GEEC DAY GEEC

--------------------------------------------------------

60.37 59.56 55.24 47.75

Zoxamide Residues Aer ial Application to Potatoes

– Input Values and EECs for GENEEC

RUN No. 3 FOR Zoxamide + Degradates INPUT VALUES

--------------------------------------------------------------------

RATE (#/AC) APPLICATIONS SOIL SOLUBILITY % SPRAY INCOR P

ONE(MULT) NO.

- INTERVAL KOC (PPM) DRIFT DEPTH(IN)

--------------------------------------------------------------------

.200( 1.235) 8 7 64.2 27.9 5.0 .0

FIELD AND STANDARD POND HALF LIFE VALUES (DAYS)

--------------------------------------------------------------------

METABOLIC DAYS UNTIL HYDROLYSIS PHOTOLYSIS METABOLIC COMBINED

(FIELD) RAIN/RUNOFF (POND) (POND

- EFF) (POND) (POND)

----------------- ---------------------------------------------------

61.80 0 N/A .00

- .00 85.40 85.40

GENERIC EECs (IN PPB)

--------------------------------------------------------

PEAK AVERAGE 4 AVERAGE 21 AV ERAGE 56

GEEC DAY GEEC DAY GEEC DAY GEEC

--------------------------------------------------------

56.97 56.22 52.14 45.06

Zoxamide Residues Ground Application to Potatoes

– Input Values and EEC s for GENEEC

RUN No. 4 FOR Zoxamide + Degradates INPUT VALUES

--------------------------------------------------------------------

RATE (#/AC) APPLICATIONS SOIL SOLUBILITY % SPRAY INCORP

ONE(MULT) NO.

- INTERVAL KOC (P PM) DRIFT DEPTH(IN)

--------------------------------------------------------------------

.200( 1.235) 8 7 64.2 27.9 1.0 .0

FIELD AND STANDARD POND HALFLIFE VALUES (DAYS)

--------------------------------- -----------------------------------

METABOLIC DAYS UNTIL HYDROLYSIS PHOTOLYSIS METABOLIC COMBINED

(FIELD) RAIN/RUNOFF (POND) (POND

- EFF) (POND) (POND)

--------------------------------------------------------------------

61.80 0 N/A .00

- .00 85.40 85.40

GENERIC EECs (IN PPB)

--------------------------------------------------------

PEAK AVERAGE 4 AVERAGE 21 AVERAGE 56

GEEC DAY GEEC DAY GEE C DAY GEEC

--------------------------------------------------------

56.27 55.51 51.49 44.50

**Zoxamide PRZM and EXAMS New York grape crop inputs for use in Ecotox calculations.**

***PRZM 3.1 Input Data File conver ted from PRZM 2.3***

***Modeler M. Corbin***

***NYGrpPnd.INP, modified from NYGrape1.inp October 31, 2000; Chautauqua County, NY.***

***Chautauqua County has highest acreage of Grapes in NY (3rd highest state in US) ***

***Erie, PA Weather Station used

- c losest to county, Grapes with grass cover ***

***Soil Hornell, Hydrologic Group D ***

***Application timing provided by Phillip Throop of Cornell U. and Fredonia Regional Extension***

***Office, Viticulture Specialist: pthroop@cce.cornell.edu; (716) 672

- 21 91.***

***All values are average of 15 years of data collection for early

- mid bloom, fruit***

## 58 ***ripening (veraison), and prior to harvest. Prior to bunch closing is assumed to occur***

***at August 1, this benchmark is not a common factor to measure and w ill vary according to

environmental***

***conditions and type of grape. This scenario is based on the Concord variety.***

***Emergence, maturation and harvest are set as early bloom, veraison and harvest.***

***Assume poor grass coverage under vines and overland flow***

***Pesticide is spray applied***

*** set up for Koc input (see records 20 and 30)***

***Meteorology Data using MET100.met (Data from 1961 to 1983)***

Zoxamide

Hornell silt loam; MLRA L

- 100, Chautauqua County, New York, Grapes

0.780 0. 300 0 15.00 1 1

4

0.33 1.00 1.00 10.00 5.80 3 15.00 354.0

1

1 0.25 90.00 100.00 3 94 91 93 0.00 150.0

1 3

0101 0106 0110

0.50 0.50 0.50

.023 .023 .023

36

310548 220848 151048 1

310549 220849 151049 1

310550 220850 151050 1

310551 220851 151051 1

310552 220852 151052 1

310553 220853 151053 1

310554 220854 151054 1

310555 220855 151055 1

310556 220856 151056 1

310557 220857 151057 1

310558 220858 151058 1

310559 220859 151059 1

310560 220860 151060 1

310561 220861 151061 1

310562 220862 151062 1

310563 220863 151063 1

310564 220864 151064 1

310565 220865 151065 1

310566 220866 151066 1

310567 220867 151067 1

310568 220868 151068 1

310569 220869 1510 69 1

310570 220870 151070 1

310571 220871 151071 1

310572 220872 151072 1

310573 220873 151073 1

310574 220874 151074 1

310575 220875 151075 1

310576 220876 151076 1

310577 220877 151077 1

310578 220878 151078 1

310579 220879 151079 1

310580 220880 151080 1

310581 220881 151081 1

310582 220882 151082 1

310583 220883 151083 1

Application Schedule: 0.2 lb a.i./acre; aerial spray, 95% effic. w/16% drift

***(early

- mid bloom, prior bunch closing, begin fruit ripening, +5 apps. prior to harvest)***

184 1 0 0

Zoxamide

140661 0 2 0.00 0.22 0.95 0.05

010861 0 2 0.00 0.22 0.95 0.05

220861 0 2 0.00 0.22 0.95 0.05

290861 0 2 0.00 0.22 0.95 0.05

050961 0 2 0.00 0.22 0.95 0.05

120961 0 2 0.00 0.22 0.95 0.05

190961 0 2 0.00 0.22 0.95 0.05

## 59 011061 0 2 0.00 0.22 0.95 0.05

140662 0 2 0.00 0.22 0.95 0.05

010862 0 2 0.00 0.22 0.95 0.05

220862 0 2 0.00 0.22 0.95 0.05

290862 0 2 0.00 0.22 0.95 0.05

050962 0 2 0.00 0.22 0.95 0.05

120962 0 2 0.00 0.22 0.95 0.05

190962 0 2 0.00 0.22 0.95 0.05

011062 0 2 0.00 0.22 0.95 0.05

140663 0 2 0.00 0 .22 0.95 0.05

010863 0 2 0.00 0.22 0.95 0.05

220863 0 2 0.00 0.22 0.95 0.05

290863 0 2 0.00 0.22 0.95 0.05

050963 0 2 0.00 0.22 0.95 0.05

120963 0 2 0.00 0.22 0.95 0.05

190963 0 2 0.00 0.22 0.95 0.05

011063 0 2 0.00 0.22 0.95 0.05

140664 0 2 0.00 0.22 0.95 0.05

010864 0 2 0.00 0.22 0.95 0.05

220864 0 2 0.00 0.22 0.95 0.05

290864 0 2 0.00 0.22 0.95 0.05

050964 0 2 0.00 0.22 0.95 0.05

120964 0 2 0.00 0.22 0.95 0.05

190964 0 2 0.00 0.22 0.95 0.05

011064 0 2 0.00 0.22 0.95 0.05

140665 0 2 0.00 0.22 0.95 0.05

010865 0 2 0.00 0.22 0.95 0.05

220865 0 2 0.00 0.22 0.95 0.05

290865 0 2 0.00 0.22 0.95 0.05

050965 0 2 0.00 0.22 0.95 0.05

120965 0 2 0.00 0.22 0.95 0.05

190965 0 2 0.00 0.22 0.95 0.05

011065 0 2 0.00 0.22 0.95 0.05

140666 0 2 0.00 0.22 0.95 0.05

010866 0 2 0.00 0.22 0.95 0.05

220866 0 2 0.00 0.22 0.95 0.05

290866 0 2 0.00 0.22 0.95 0.05

050966 0 2 0.00 0 .22 0.95 0.05

120966 0 2 0.00 0.22 0.95 0.05

190966 0 2 0.00 0.22 0.95 0.05

011066 0 2 0.00 0.22 0.95 0.05

140667 0 2 0.00 0.22 0.95 0.05

010867 0 2 0.00 0.22 0.95 0.05

220867 0 2 0.00 0.22 0.95 0.05

290867 0 2 0.00 0.22 0.95 0.05

050967 0 2 0.00 0.22 0.95 0.05

120967 0 2 0.00 0.22 0.95 0.05

190967 0 2 0.00 0.22 0.95 0.05

011067 0 2 0.00 0.22 0.95 0.05

140668 0 2 0.00 0.22 0.95 0.05

010868 0 2 0.00 0.22 0.95 0.05

220868 0 2 0.00 0.22 0.95 0.05

290868 0 2 0.00 0.22 0.95 0.05

050968 0 2 0.00 0.22 0.95 0.05

120968 0 2 0.00 0.22 0.95 0.05

190968 0 2 0.00 0.22 0.95 0.05

011068 0 2 0.00 0.22 0.95 0.05

140669 0 2 0.00 0.22 0.95 0.05

010869 0 2 0.00 0.22 0.95 0.05

220869 0 2 0.00 0.22 0.95 0.05

290869 0 2 0.00 0.22 0.95 0.05

050969 0 2 0.00 0.22 0.95 0.05

120969 0 2 0.00 0.22 0.95 0.05

190969 0 2 0.00 0.22 0.95 0.05

011069 0 2 0.00 0.22 0.95 0.05

140670 0 2 0.00 0.22 0.95 0.05

010870 0 2 0.00 0.22 0.95 0.05

220870 0 2 0.00 0.22 0.95 0.05

## 60 290870 0 2 0.00 0.22 0.95 0.05

050970 0 2 0.00 0.22 0.95 0.05

120970 0 2 0.00 0.22 0.95 0.05

190970 0 2 0.00 0.22 0.95 0.05

011070 0 2 0.00 0.22 0.95 0.05

140671 0 2 0.00 0.22 0.95 0.05

010871 0 2 0.00 0.22 0.95 0.05

220871 0 2 0.00 0.22 0.95 0.05

290871 0 2 0.00 0.22 0.95 0.05

050971 0 2 0.00 0.22 0.95 0.05

120971 0 2 0.00 0.22 0.95 0.05

190971 0 2 0.00 0.22 0.95 0.05

011071 0 2 0.00 0.22 0.95 0.05

140672 0 2 0.00 0.22 0.95 0.05

010872 0 2 0.00 0.22 0.95 0.05

220872 0 2 0.00 0.22 0.95 0.05

290872 0 2 0.00 0.22 0.95 0.05

050972 0 2 0.00 0.22 0.95 0.05

120972 0 2 0.00 0.22 0.95 0.05

190972 0 2 0.00 0.22 0.95 0.05

011072 0 2 0.00 0.22 0.95 0.05

140673 0 2 0.00 0.22 0.95 0.05

010873 0 2 0.00 0.22 0.95 0.05

220873 0 2 0.00 0.22 0.95 0.05

290873 0 2 0.00 0.22 0.95 0.05

050973 0 2 0.00 0.22 0.95 0.05

120973 0 2 0.00 0.22 0.95 0.05

190973 0 2 0.00 0.22 0.95 0.05

011073 0 2 0.00 0.22 0.95 0.05

140674 0 2 0.00 0.22 0.95 0.05

010874 0 2 0.00 0.22 0.95 0.05

220874 0 2 0.00 0.22 0.95 0.05

290874 0 2 0.00 0.22 0.95 0.05

050974 0 2 0.00 0.22 0.95 0.05

120974 0 2 0.00 0.22 0.95 0.05

190974 0 2 0.00 0.22 0.95 0.05

011074 0 2 0.00 0.22 0.95 0.05

140675 0 2 0.00 0.22 0.95 0.05

010875 0 2 0.00 0.22 0.95 0.05

220875 0 2 0.00 0 .22 0.95 0.05

290875 0 2 0.00 0.22 0.95 0.05

050975 0 2 0.00 0.22 0.95 0.05

120975 0 2 0.00 0.22 0.95 0.05

190975 0 2 0.00 0.22 0.95 0.05

011075 0 2 0.00 0.22 0.95 0.05

140676 0 2 0.00 0.22 0.95 0.05

010876 0 2 0.00 0.22 0.95 0 .05

220876 0 2 0.00 0.22 0.95 0.05

290876 0 2 0.00 0.22 0.95 0.05

050976 0 2 0.00 0.22 0.95 0.05

120976 0 2 0.00 0.22 0.95 0.05

190976 0 2 0.00 0.22 0.95 0.05

011076 0 2 0.00 0.22 0.95 0.05

140677 0 2 0.00 0.22 0.95 0.05

010877 0 2 0.00 0.22 0.95 0.05

220877 0 2 0.00 0.22 0.95 0.05

290877 0 2 0.00 0.22 0.95 0.05

050977 0 2 0.00 0.22 0.95 0.05

120977 0 2 0.00 0.22 0.95 0.05

190977 0 2 0.00 0.22 0.95 0.05

011077 0 2 0.00 0.22 0.95 0.05

140678 0 2 0.00 0.22 0.95 0.05

010878 0 2 0.00 0.22 0.95 0.05

220878 0 2 0.00 0.22 0.95 0.05

290878 0 2 0.00 0.22 0.95 0.05

050978 0 2 0.00 0.22 0.95 0.05

120978 0 2 0.00 0.22 0.95 0.05

190978 0 2 0.00 0.22 0.95 0.05

## 61 011078 0 2 0.00 0.22 0.95 0.05

140679 0 2 0.00 0.22 0.95 0.05

010879 0 2 0.00 0.22 0.95 0.05

220879 0 2 0.00 0.22 0.95 0.05

290879 0 2 0.00 0.22 0.95 0.05

050979 0 2 0.00 0.22 0.95 0.05

120979 0 2 0.00 0.22 0.95 0.05

190979 0 2 0.00 0.22 0.95 0.05

011079 0 2 0.00 0.22 0.95 0.05

140680 0 2 0.00 0.22 0.95 0.05

010880 0 2 0.00 0.22 0.95 0.05

220880 0 2 0.00 0.22 0.95 0.05

290880 0 2 0.00 0.22 0.95 0.05

050980 0 2 0.00 0.22 0.95 0.05

120980 0 2 0.00 0.22 0.95 0.05

190980 0 2 0.00 0.22 0.95 0.05

011080 0 2 0.00 0.22 0.95 0.05

140681 0 2 0.00 0.22 0.95 0.05

010881 0 2 0.00 0.22 0.95 0.05

220881 0 2 0.00 0.22 0.95 0.05

290881 0 2 0.00 0.22 0.95 0.05

050981 0 2 0.00 0.22 0.95 0.05

120981 0 2 0.00 0.22 0.95 0.05

190981 0 2 0.00 0.22 0.95 0.05

011081 0 2 0.00 0.22 0.95 0.05

140682 0 2 0.00 0.22 0.95 0.05

010882 0 2 0.00 0.22 0.95 0.05

220882 0 2 0.00 0.22 0.95 0.05

290882 0 2 0.00 0. 22 0.95 0.05

050982 0 2 0.00 0.22 0.95 0.05

120982 0 2 0.00 0.22 0.95 0.05

190982 0 2 0.00 0.22 0.95 0.05

011082 0 2 0.00 0.22 0.95 0.05

140683 0 2 0.00 0.22 0.95 0.05

010883 0 2 0.00 0.22 0.95 0.05

220883 0 2 0.00 0.22 0.95 0.05

290883 0 2 0.00 0.22 0.95 0.05

050983 0 2 0.00 0.22 0.95 0.05

120983 0 2 0.00 0.22 0.95 0.05

190983 0 2 0.00 0.22 0.95 0.05

011083 0 2 0.00 0.22 0.95 0.05

0.0 3 0.0

0.00 0.00 0.50

Hornell Silt Loam; Hydrologic Group D;

100.00 0.0 0 0 1 0 0 0 0 0 0

0.0 0.0 0.0

4 1345.

3

1 18.00 1.400 0.322 0.000 0.000 0.00

.01791 .01791 0.000

0.1 0.322 0.162 1.740 0.0

2 66.00 1.500 0.310 0.000 0.000 0.00

.01791 .01791 0.000

1.0 0.310 0.200 0.174 0.0

3 16.00 1.950 0.260 0.000 0.000 0.00

.01791 .01791 0.00 0

1.0 0.260 0.190 0.116 0.0

0

YEAR 5 YEAR 5 YEAR 5 1

1

1

-----

6 YEAR

PRCP TSER 0 0

RUNF TSER 0 0

ESLS TSER 0 0 1.0E3

RFLX TSER 0 0 1.0E5

EFLX TSER 0 0 1.0E5

RZFX TSER 0 0 1.0E5

## 62 **Zoxamide PRZM and EXAMS New York grape crop output for use in Ecotox calculations.**

WATER COLUMN DISSOLVED CO NCENTRATION (PPB)

YEAR PEAK 96 HOUR 21 DAY 60 DAY 90 DAY YEARLY

1961 1.994 1.015 0.457 0.302 0.266 0.106

1962 5.367 2.856 1.108 0.580 0.514 0.190

1963 2.737 1.851 0.650 0.308 0.271 0.113

1964 2.450 1.185 0.458 0.299 0.283 0.127

1965 3.768 2.118 0.662 0.432 0.369 0.143

1966 1.686 0.952 0.478 0.344 0.310 0.144

1967 3.725 2.029 0.845 0.567 0.478 0.178

1968 1.631 0.984 0.398 0.344 0.295 0.124

1969 1.547 1.029 0.404 0.308 0.260 0.105

1970 5.242 2.680 1.405 0.734 0.56 1 0.205

1971 2.801 1.923 0.728 0.563 0.432 0.161

1972 3.094 1.634 0.955 0.486 0.406 0.166

1973 1.338 0.806 0.439 0.298 0.260 0.102

1974 1.330 0.849 0.423 0. 298 0.281 0.124

1975 4.162 2.726 1.061 0.603 0.449 0.175

1976 2.407 1.460 0.615 0.484 0.369 0.145

1977 6.636 4.276 2.532 1.191 0.936 0.354

1978 3.752 2.155 1.129 0.641 0.537 0.189

1979 16.480 8.367 2.590 1.514 1.084 0.346

1980 4.861 3.055 1.047 0.853 0.715 0.249

1981 6.402 3.595 1.141 0.586 0.460 0.167

1982 2.571 1.357 0.627 0.445 0.400 0.154

1983 8.073 4.325 1.548 0.819 0.645 0.223

SORTED FOR PLOTTING

PROB PEAK 96 HOUR 21 DAY 60 DAY 90 DAY YEARLY

0.042 1 6.480 8.367 2.590 1.514 1.084 0.354

0.083 8.073 4.325 2.532 1.191 0.936 0.346

0.125 6.636 4.276 1.548 0.853 0.715 0.249

0.167 6.402 3.595 1.405 0.819 0.6 45 0.223

0.208 5.367 3.055 1.141 0.734 0.561 0.205

0.250 5.242 2.856 1.129 0.641 0.537 0.190

0.292 4.861 2.726 1.108 0.603 0.514 0.189

0.333 4.162 2.680 1.061 0.586 0.478 0.178

0.375 3.768 2.155 1.047 0.580 0.460 0.175

0.417 3.752 2.118 0.955 0.567 0.449 0.167

0.458 3.725 2.029 0.845 0.563 0.432 0.166

0.500 3.094 1.923 0.728 0.486 0.406 0.161

0.542 2.801 1.851 0.662 0.484 0.400 0.154

0.583 2.737 1.634 0.650 0.445 0.369 0.145

0.625 2.571 1.460 0.627 0.432 0.369 0.144

0.667 2.450 1.357 0.615 0.344 0.310 0.143

0.708 2.407 1.185 0.478 0.344 0.295 0.127

0.750 1.994 1.029 0.458 0.308 0.2 83 0.124

0.792 1.686 1.015 0.457 0.308 0.281 0.124

0.833 1.631 0.984 0.439 0.302 0.271 0.113

0.875 1.547 0.952 0.423 0.299 0.266 0.106

0.917 1.338 0.849 0.404 0.298 0.260 0.105

0.958 1.330 0.806 0.398 0.298 0.260 0.102

1/10 7.498 4.305 2.138 1.056 0.848 0.307

MEAN OF ANNUAL VALUES = 0.173

STANDARD DEVIATION OF ANNUAL VALUES = 0.068

UPPER 90% CONFIDENCE LIMIT ON MEAN = 0.194

**Zoxamide PRZM and EXAMS Maine potato crop inputs for use in Ecotox calculations.**

*** PRZM 3.1 Input Data File coverted from PRZM 2.3; S.ABEL ***

## 63 *** MEPoPond.INP created October 26, 2000 ***

*** Modeler: M. Corbin ***

*** Assume 4% slope, conventional tillage with crop residue left ***

*** on the field after harvest ***

*** Manning's N value for planted across slope poor stand at ***

*** 20% maturity (for small grains) ***

*** Applica tion by aerial spray ***

*** PCA for potatoes not available, use default PCA of 0.87 ***

Zoxamide

Conant Silt Loam MLRA M

- 143, Arastook County, ME

0.770 0.150 0 12.50 1 3

4

0.28 0.44 1.00 10.00 5.80 3 4.00 354.00

1

1 0.10 30.00 90.00 3 91 85 88 0.00 60.0

1 3

0101 0105 0109

0.43 0.27 0.43

.018 .018 .018

36

050548 080948 180948 1

050549 080949 180949 1

050550 08 0950 180950 1

050551 080951 180951 1

050552 080952 180952 1

050553 080953 180953 1

050554 080954 180954 1

050555 080955 180955 1

050556 080956 180956 1

050557 080957 180957 1

050558 080958 180958 1

050559 080959 180959 1

050560 080960 180960 1

050561 080961 180961 1

050562 080962 180962 1

050563 080963 180963 1

050564 080964 180964 1

050565 080965 180965 1

050566 080966 180966 1

050567 080967 180967 1

050568 080968 180968 1

050569 080969 180969 1

050570 080970 180970 1

050571 080971 180971 1

050572 080972 180972 1

050573 080973 180973 1

050574 080974 180974 1

050575 080975 180975 1

050576 080976 180976 1

050577 080977 180977 1

050578 080978 180978 1

050579 080979 180979 1

050580 080980 180980 1

050581 080981 180981 1

050582 080982 180982 1

050583 080983 180983 1

Application Schedule: Aerial Spray @ 0.22 kgs a.i/ha, 8 times @ 5 day intervals,

288 1 0 0

Zoxamide:

060548 0 2 0.0 0.22 0.95 0.05

110548 0 2 0.0 0.22 0.95 0.05

160548 0 2 0.0 0.22 0.95 0.05

210548 0 2 0.0 0.22 0.95 0.05

260548 0 2 0.0 0.22 0.95 0.05

310548 0 2 0.0 0.22 0.95 0.05

050648 0 2 0.0 0.22 0.95 0.05

110648 0 2 0.0 0.22 0.95 0.05

060549 0 2 0.0 0.22 0.95 0.05

## 64 110549 0 2 0.0 0.22 0.95 0.05

160549 0 2 0.0 0.22 0.95 0.05

210549 0 2 0.0 0.22 0.95 0.05

260549 0 2 0.0 0.22 0.95 0.05

310549 0 2 0.0 0.22 0.95 0.05

050649 0 2 0.0 0.22 0.95 0.05

110649 0 2 0.0 0.22 0.95 0.05

060550 0 2 0.0 0.22 0.95 0.05

110550 0 2 0.0 0.22 0.95 0.05

160550 0 2 0.0 0.22 0.95 0.05

210550 0 2 0.0 0.22 0.95 0.05

260550 0 2 0.0 0.22 0.95 0.05

310550 0 2 0.0 0.22 0.95 0.05

050650 0 2 0.0 0.22 0.95 0.05

110650 0 2 0.0 0.22 0.95 0.05

060551 0 2 0.0 0.22 0.95 0.05

110551 0 2 0.0 0.22 0.95 0.05

160551 0 2 0.0 0.22 0.95 0.05

210551 0 2 0.0 0.22 0.95 0.05

260551 0 2 0.0 0.22 0.95 0.05

310551 0 2 0.0 0.22 0.95 0.05

050651 0 2 0.0 0.22 0.95 0.05

110651 0 2 0.0 0.22 0.95 0.05

060552 0 2 0.0 0.22 0.95 0.05

110552 0 2 0.0 0.22 0.95 0.05

160552 0 2 0.0 0. 22 0.95 0.05

210552 0 2 0.0 0.22 0.95 0.05

260552 0 2 0.0 0.22 0.95 0.05

310552 0 2 0.0 0.22 0.95 0.05

050652 0 2 0.0 0.22 0.95 0.05

110652 0 2 0.0 0.22 0.95 0.05

060553 0 2 0.0 0.22 0.95 0.05

110553 0 2 0.0 0.22 0.95 0.05

160553 0 2 0.0 0.22 0.95 0.05

210553 0 2 0.0 0.22 0.95 0.05

260553 0 2 0.0 0.22 0.95 0.05

310553 0 2 0.0 0.22 0.95 0.05

050653 0 2 0.0 0.22 0.95 0.05

110653 0 2 0.0 0.22 0.95 0.05

060554 0 2 0.0 0.22 0.95 0.05

110554 0 2 0.0 0.22 0.95 0.05

160554 0 2 0.0 0.22 0.95 0.05

210554 0 2 0.0 0.22 0.95 0.05

260554 0 2 0.0 0.22 0.95 0.05

310554 0 2 0.0 0.22 0.95 0.05

050654 0 2 0.0 0.22 0.95 0.05

110654 0 2 0.0 0.22 0.95 0.05

060555 0 2 0.0 0.22 0.95 0.05

110555 0 2 0.0 0.22 0.95 0.05

160555 0 2 0.0 0.22 0.95 0.05

210555 0 2 0.0 0.22 0.95 0.05

260555 0 2 0.0 0.22 0.95 0.05

310555 0 2 0.0 0.22 0.95 0.05

050655 0 2 0.0 0.22 0.95 0.05

110655 0 2 0.0 0.22 0.95 0.05

060556 0 2 0.0 0.22 0.95 0.05

110556 0 2 0.0 0.22 0.95 0.05

160556 0 2 0.0 0.22 0.95 0.05

210556 0 2 0.0 0.22 0.95 0.05

260556 0 2 0.0 0.22 0.95 0.05

310556 0 2 0.0 0.22 0.95 0.05

050656 0 2 0.0 0.22 0.95 0.05

110656 0 2 0.0 0.22 0.95 0.05

060557 0 2 0.0 0.22 0.95 0.05

110557 0 2 0.0 0.22 0.95 0.05

160557 0 2 0.0 0.22 0.95 0.05

210557 0 2 0.0 0.22 0.95 0.05

260557 0 2 0.0 0.22 0.95 0.05

## 65 310557 0 2 0.0 0.22 0.95 0.05

050657 0 2 0.0 0.22 0.95 0.05

110657 0 2 0.0 0.22 0.95 0.05

060558 0 2 0.0 0.22 0.95 0.05

110558 0 2 0.0 0.22 0.95 0.05

160558 0 2 0.0 0.22 0.95 0.05

210558 0 2 0.0 0.22 0.95 0.05

260558 0 2 0.0 0. 22 0.95 0.05

310558 0 2 0.0 0.22 0.95 0.05

050658 0 2 0.0 0.22 0.95 0.05

110658 0 2 0.0 0.22 0.95 0.05

060559 0 2 0.0 0.22 0.95 0.05

110559 0 2 0.0 0.22 0.95 0.05

160559 0 2 0.0 0.22 0.95 0.05

210559 0 2 0.0 0.22 0.95 0.0 5

260559 0 2 0.0 0.22 0.95 0.05

310559 0 2 0.0 0.22 0.95 0.05

050659 0 2 0.0 0.22 0.95 0.05

110659 0 2 0.0 0.22 0.95 0.05

060560 0 2 0.0 0.22 0.95 0.05

110560 0 2 0.0 0.22 0.95 0.05

160560 0 2 0.0 0.22 0.95 0.05

210560 0 2 0.0 0.22 0.95 0.05

260560 0 2 0.0 0.22 0.95 0.05

310560 0 2 0.0 0.22 0.95 0.05

050660 0 2 0.0 0.22 0.95 0.05

110660 0 2 0.0 0.22 0.95 0.05

060561 0 2 0.0 0.22 0.95 0.05

110561 0 2 0.0 0.22 0.95 0.05

160561 0 2 0.0 0.22 0.95 0.05

210561 0 2 0.0 0.22 0.95 0.05

260561 0 2 0.0 0.22 0.95 0.05

310561 0 2 0.0 0.22 0.95 0.05

050661 0 2 0.0 0.22 0.95 0.05

110661 0 2 0.0 0.22 0.95 0.05

060562 0 2 0.0 0.22 0.95 0.05

110562 0 2 0.0 0. 22 0.95 0.05

160562 0 2 0.0 0.22 0.95 0.05

210562 0 2 0.0 0.22 0.95 0.05

260562 0 2 0.0 0.22 0.95 0.05

310562 0 2 0.0 0.22 0.95 0.05

050662 0 2 0.0 0.22 0.95 0.05

110662 0 2 0.0 0.22 0.95 0.05

060563 0 2 0.0 0.22 0.95 0.05

110563 0 2 0.0 0.22 0.95 0.05

160563 0 2 0.0 0.22 0.95 0.05

210563 0 2 0.0 0.22 0.95 0.05

260563 0 2 0.0 0.22 0.95 0.05

310563 0 2 0.0 0.22 0.95 0.05

050663 0 2 0.0 0.22 0.95 0.05

110663 0 2 0.0 0.22 0.95 0.05

060564 0 2 0.0 0.22 0.95 0.05

110564 0 2 0.0 0.22 0.95 0.05

160564 0 2 0.0 0.22 0.95 0.05

210564 0 2 0.0 0.22 0.95 0.05

260564 0 2 0.0 0.22 0.95 0.05

310564 0 2 0.0 0.22 0.95 0.05

050664 0 2 0.0 0. 22 0.95 0.05

110664 0 2 0.0 0.22 0.95 0.05

060565 0 2 0.0 0.22 0.95 0.05

110565 0 2 0.0 0.22 0.95 0.05

160565 0 2 0.0 0.22 0.95 0.05

210565 0 2 0.0 0.22 0.95 0.05

260565 0 2 0.0 0.22 0.95 0.05

310565 0 2 0.0 0.22 0.95 0.0 5

050665 0 2 0.0 0.22 0.95 0.05

110665 0 2 0.0 0.22 0.95 0.05

060566 0 2 0.0 0.22 0.95 0.05

## 66 110566 0 2 0.0 0.22 0.95 0.05

160566 0 2 0.0 0.22 0.95 0.05

210566 0 2 0.0 0.22 0.95 0.05

260566 0 2 0.0 0.22 0.95 0.05

310566 0 2 0.0 0.22 0.95 0.05

050666 0 2 0.0 0.22 0.95 0.05

110666 0 2 0.0 0.22 0.95 0.05

060567 0 2 0.0 0.22 0.95 0.05

110567 0 2 0.0 0.22 0.95 0.05

160567 0 2 0.0 0.22 0.95 0.05

210567 0 2 0.0 0.22 0.95 0.05

260567 0 2 0.0 0.22 0.95 0.05

310567 0 2 0.0 0.22 0.95 0.05

050667 0 2 0.0 0.22 0.95 0.05

110667 0 2 0.0 0.22 0.95 0.05

060568 0 2 0.0 0.22 0.95 0.05

110568 0 2 0.0 0.22 0.95 0.05

160568 0 2 0.0 0.22 0.95 0.05

210568 0 2 0.0 0. 22 0.95 0.05

260568 0 2 0.0 0.22 0.95 0.05

310568 0 2 0.0 0.22 0.95 0.05

050668 0 2 0.0 0.22 0.95 0.05

110668 0 2 0.0 0.22 0.95 0.05

060569 0 2 0.0 0.22 0.95 0.05

110569 0 2 0.0 0.22 0.95 0.05

160569 0 2 0.0 0.22 0.95 0.05

210569 0 2 0.0 0.22 0.95 0.05

260569 0 2 0.0 0.22 0.95 0.05

310569 0 2 0.0 0.22 0.95 0.05

050669 0 2 0.0 0.22 0.95 0.05

110669 0 2 0.0 0.22 0.95 0.05

060570 0 2 0.0 0.22 0.95 0.05

110570 0 2 0.0 0.22 0.95 0.05

160570 0 2 0.0 0.22 0.95 0.05

210570 0 2 0.0 0.22 0.95 0.05

260570 0 2 0.0 0.22 0.95 0.05

310570 0 2 0.0 0.22 0.95 0.05

050670 0 2 0.0 0.22 0.95 0.05

110670 0 2 0.0 0.22 0.95 0.05

060571 0 2 0.0 0. 22 0.95 0.05

110571 0 2 0.0 0.22 0.95 0.05

160571 0 2 0.0 0.22 0.95 0.05

210571 0 2 0.0 0.22 0.95 0.05

260571 0 2 0.0 0.22 0.95 0.05

310571 0 2 0.0 0.22 0.95 0.05

050671 0 2 0.0 0.22 0.95 0.05

110671 0 2 0.0 0.22 0.95 0.05

060572 0 2 0.0 0.22 0.95 0.05

110572 0 2 0.0 0.22 0.95 0.05

160572 0 2 0.0 0.22 0.95 0.05

210572 0 2 0.0 0.22 0.95 0.05

260572 0 2 0.0 0.22 0.95 0.05

310572 0 2 0.0 0.22 0.95 0.05

050672 0 2 0.0 0.22 0.95 0.05

110672 0 2 0.0 0.22 0.95 0.05

060573 0 2 0.0 0.22 0.95 0.05

110573 0 2 0.0 0.22 0.95 0.05

160573 0 2 0.0 0.22 0.95 0.05

210573 0 2 0.0 0.22 0.95 0.05

260573 0 2 0.0 0.22 0.95 0.05

310573 0 2 0.0 0.22 0.95 0.05

050673 0 2 0.0 0.22 0.95 0.05

110673 0 2 0.0 0.22 0.95 0.05

060574 0 2 0.0 0.22 0.95 0.05

110574 0 2 0.0 0.22 0.95 0.05

160574 0 2 0.0 0.22 0.95 0.05

210574 0 2 0.0 0.22 0.95 0.05

260574 0 2 0.0 0.22 0.95 0.05

## 67 310574 0 2 0.0 0. 22 0.95 0.05

050674 0 2 0.0 0.22 0.95 0.05

110674 0 2 0.0 0.22 0.95 0.05

060575 0 2 0.0 0.22 0.95 0.05

110575 0 2 0.0 0.22 0.95 0.05

160575 0 2 0.0 0.22 0.95 0.05

210575 0 2 0.0 0.22 0.95 0.05

260575 0 2 0.0 0.22 0.95 0.05

310575 0 2 0.0 0.22 0.95 0.05

050675 0 2 0.0 0.22 0.95 0.05

110675 0 2 0.0 0.22 0.95 0.05

060576 0 2 0.0 0.22 0.95 0.05

110576 0 2 0.0 0.22 0.95 0.05

160576 0 2 0.0 0.22 0.95 0.05

210576 0 2 0.0 0.22 0.95 0.05

260576 0 2 0.0 0.22 0.95 0.05

310576 0 2 0.0 0.22 0.95 0.05

050676 0 2 0.0 0.22 0.95 0.05

110676 0 2 0.0 0.22 0.95 0.05

060577 0 2 0.0 0.22 0.95 0.05

110577 0 2 0.0 0.22 0.95 0.05

160577 0 2 0.0 0. 22 0.95 0.05

210577 0 2 0.0 0.22 0.95 0.05

260577 0 2 0.0 0.22 0.95 0.05

310577 0 2 0.0 0.22 0.95 0.05

050677 0 2 0.0 0.22 0.95 0.05

110677 0 2 0.0 0.22 0.95 0.05

060578 0 2 0.0 0.22 0.95 0.05

110578 0 2 0.0 0.22 0.95 0.0 5

160578 0 2 0.0 0.22 0.95 0.05

210578 0 2 0.0 0.22 0.95 0.05

260578 0 2 0.0 0.22 0.95 0.05

310578 0 2 0.0 0.22 0.95 0.05

050678 0 2 0.0 0.22 0.95 0.05

110678 0 2 0.0 0.22 0.95 0.05

060579 0 2 0.0 0.22 0.95 0.05

110579 0 2 0.0 0.22 0.95 0.05

160579 0 2 0.0 0.22 0.95 0.05

210579 0 2 0.0 0.22 0.95 0.05

260579 0 2 0.0 0.22 0.95 0.05

310579 0 2 0.0 0.22 0.95 0.05

050679 0 2 0.0 0.22 0.95 0.05

110679 0 2 0.0 0.22 0.95 0.05

060580 0 2 0.0 0.22 0.95 0.05

110580 0 2 0.0 0.22 0.95 0.05

160580 0 2 0.0 0.22 0.95 0.05

210580 0 2 0.0 0.22 0.95 0.05

260580 0 2 0.0 0.22 0.95 0.05

310580 0 2 0.0 0.22 0.95 0.05

050680 0 2 0.0 0.22 0.95 0.05

110680 0 2 0.0 0.22 0.95 0.05

060581 0 2 0.0 0.22 0.95 0.05

110581 0 2 0.0 0.22 0.95 0.05

160581 0 2 0.0 0.22 0.95 0.05

210581 0 2 0.0 0.22 0.95 0.05

260581 0 2 0.0 0.22 0.95 0.05

310581 0 2 0.0 0.22 0.95 0.05

050681 0 2 0.0 0.22 0.95 0.05

110681 0 2 0.0 0.22 0.95 0.05

060582 0 2 0.0 0.22 0.95 0.05

110582 0 2 0.0 0.22 0.95 0.05

160582 0 2 0.0 0.22 0.95 0.05

210582 0 2 0.0 0.22 0.95 0.05

260582 0 2 0.0 0.22 0.95 0.05

310582 0 2 0.0 0.22 0.95 0.05

050682 0 2 0.0 0.22 0.95 0.05

110682 0 2 0.0 0.22 0.95 0.05

060583 0 2 0.0 0.22 0.95 0.05

## 68 110583 0 2 0.0 0.22 0.95 0.05

160583 0 2 0.0 0.22 0.95 0.05

210583 0 2 0.0 0.22 0.95 0.05

260583 0 2 0.0 0.22 0.95 0.05

310583 0 2 0.0 0.22 0.95 0.05

050683 0 2 0.0 0.22 0.95 0.05

110683 0 2 0.0 0.22 0.95 0.05

0.0 3

0.0 0.0 0.5

Soil Series: Conant Silt Loam

100.00 0 0 1 0 0 0 0 0 0

0.0 0.00 0. 00

4 1345.0

4

1 10.00 1.250 0.341 0.000 0.000 0.000

.01791 .01791 0.000

0.1 0.341 0.121 4.640 0.0

2 16.00 1.250 0.341 0.000 0.000 0.000

.01791 .01791 0.000

1.0 0.341 0.121 4.640 0.0

3 64.00 1.400 0.266 0.000 0.000 0.000

.01791 .01791 0.000

1.0 0.266 0.116 0.174 0.0

4 10.00 1.600 0.261 0.000 0.000 0.000

.01791 .01791 0.000

1.0 0.261 0.111 0.116 0.0

0

WATR YEAR 10 PEST YEAR 10 CONC YEAR 10 1

1

1

-----

6 DAY

PRCP TSER 0 0

RUNF TSER 0 0

ESLS TSER 0 0 1.0E3

RFLX TSER 0 0 1.0E5

EFLX TSER 0 0 1.0E5

RZFX TSER 0 0 1.0E5

**Zoxamide PRZM and EXAMS Maine potato crop output for use in Ecotox calculations.**

WATER COLUMN DISSOLVED CONCENTRATION (PPB)

YEAR PEAK 96 HOUR 21 DAY 60 DAY 90 DAY YEARLY

1948 0.678 0.363 0.328 0.226 0.178 0.057

1949 0.667 0.362 0.326 0.206 0.160 0.051

1950 0.670 0.390 0.334 0.211 0.145 0.045

1951 0.667 0.362 0.326 0.212 0.162 0.048

1952 2.098 1.090 0.509 0.296 0.206 0.061

1953 0.729 0.385 0.332 0.234 0.16 4 0.057

1954 0.757 0.487 0.362 0.234 0.158 0.051

1955 3.478 1.813 0.895 0.439 0.309 0.101

1956 1.894 1.040 0.554 0.303 0.218 0.065

1957 2.640 1.430 0.439 0. 367 0.277 0.087

1958 0.800 0.549 0.379 0.237 0.162 0.048

1959 1.272 0.662 0.353 0.260 0.177 0.052

1960 1.251 0.654 0.406 0.305 0.217 0.067

1961 0.810 0 .408 0.341 0.247 0.176 0.052

1962 0.671 0.366 0.328 0.225 0.178 0.055

1963 0.667 0.363 0.328 0.207 0.144 0.044

1964 0.810 0.483 0.410 0.249 0.172 0.055

1965 1.661 0.868 0.461 0.276 0.190 0.062

1966 0.739 0.386 0.340 0.217 0.146 0.046

1967 0.678 0.369 0.331 0.217 0.161 0.049

1968 0.731 0.398 0.339 0.221 0.151 0.04 4

1969 1.138 0.714 0.425 0.288 0.197 0.057

1970 0.716 0.453 0.356 0.252 0.177 0.054

1971 0.668 0.363 0.328 0.213 0.153 0.049

1972 3.486 1.807 0.626 0.373 0.280 0.079

## 69 1973 2.023 1.111 0.575 0.398 0.287 0.086

1974 2.030 1.055 0.371 0.318 0.221 0.065

1975 0.667 0.362 0.326 0.206 0.15 6 0.047

1976 1.428 0.782 0.517 0.326 0.224 0.068

1977 0.786 0.378 0.326 0.206 0.142 0.049

1978 0.708 0.401 0.333 0.225 0.156 0.046

1979 0.858 0.497 0.368 0. 226 0.152 0.048

1980 1.105 0.553 0.326 0.207 0.192 0.059

1981 1.081 0.647 0.424 0.252 0.171 0.060

1982 1.041 0.656 0.420 0.298 0.219 0.067

1983 1.880 1.108 0.526 0.289 0.207 0.072

SORTED FOR PLOTTING

PROB PEAK 96 HOUR 21 DAY 60 DAY 90 DAY YEARLY

0.027 3.486 1.813 0.895 0.439 0.309 0.101

0.054 3.478 1.807 0.626 0.398 0.287 0.087

0.081 2.640 1.430 0.575 0.373 0.280 0.086

0.108 2.098 1.111 0.554 0.367 0.277 0.079

0.135 2.030 1.108 0.526 0.326 0.224 0.072

0.162 2.023 1.090 0.517 0.318 0.221 0.068

0.189 1.894 1.055 0.509 0.305 0.219 0.067

0.216 1.880 1.040 0.461 0.303 0.218 0.067

0.243 1.661 0.868 0.439 0. 298 0.217 0.065

0.270 1.428 0.782 0.425 0.296 0.207 0.065

0.297 1.272 0.714 0.424 0.289 0.206 0.062

0.324 1.251 0.662 0.420 0.288 0.197 0.061

0.351 1.138 0.656 0.410 0.276 0.192 0.060

0.378 1.105 0.654 0.406 0.260 0.190 0.059

0.405 1.081 0.647 0.379 0.252 0.178 0.057

0.432 1.041 0.553 0.371 0.252 0.178 0.057

0.459 0.858 0.549 0.368 0.249 0.177 0.057

0.486 0.810 0.497 0.362 0.247 0.177 0.055

0.514 0.810 0.487 0.356 0.237 0.176 0.055

0.541 0.800 0.483 0.353 0.234 0.172 0.054

0.568 0.786 0.453 0.341 0.234 0.171 0.052

0.595 0.757 0.408 0.340 0.226 0.164 0.052

0.622 0.739 0.401 0.339 0.226 0.1 62 0.051

0.649 0.731 0.398 0.334 0.225 0.162 0.051

0.676 0.729 0.390 0.333 0.225 0.161 0.049

0.703 0.716 0.386 0.332 0.221 0.160 0.049

0.730 0.708 0.385 0.331 0.217 0.158 0.049

0.757 0.678 0.378 0.328 0.217 0.156 0.048

0.784 0.678 0.369 0.328 0.213 0.156 0.048

0.811 0.671 0.366 0.328 0.212 0.153 0.048

0.838 0.670 0.363 0.328 0.211 0.152 0.047

0.865 0.668 0.363 0.326 0.207 0.151 0.046

0.892 0.667 0.363 0.326 0.207 0.146 0.046

0.919 0.667 0.362 0.326 0.206 0.145 0.045

0.946 0.667 0.362 0.326 0.206 0.144 0.044

0.973 0.667 0.362 0.326 0.206 0.142 0.044

1/10 2.261 1.207 0.560 0.369 0.278 0.081

MEAN OF ANNUAL VALUES = 0.058

STANDARD DEVIATION OF ANNUAL VALUES = 0.013

UPPER 90% CONFIDENCE LIMIT ON MEAN = 0.062

**Zoxamide PRZM and EXAMS New York grape crop input for use in index reservoir/PCA calculations.**

***P RZM 3.1 Input Data File converted from PRZM 2.3***

***Modeler M. Corbin***

***IRNYGrp.INP, modified from NYGrape1.inp October 31, 2000; Chautauqua County, NY.***

***Chautauqua County has highest acreage of Grapes in NY (3rd highest state in US) ***

## 70 ***Erie , PA Weather Station used

- closest to county, Grapes with grass cover ***

***Soil Hornell, Hydrologic Group D ***

***Application timing provided by Phillip Throop of Cornell U. and Fredonia Regional Extension***

***Office, Viticulture Specialist: pthroop@ cce.cornell.edu; (716) 672

- 2191.***

***All values are average of 15 years of data collection for early

- mid bloom, fruit***

***ripening (veraison), and prior to harvest. Prior to bunch closing is assumed to accur***

***at August 1, this benchmark is not a c ommon factor to measure and will vary according to

environmental***

***conditions and type of grape. This scenario is based on the Concord variety.***

***Emergence, maturation and harvest are set as early bloom, veraison and harvest.***

***Assume poor grass coverage under vines and overland flow***

***Pesticide is aerial spray applied***

*** set up for Koc input (see records 20 and 30)***

***Meteorology Data using MET100.met (Data from 1961 to 1983)***

Zoxamide

Hornell silt loam; MLRA L

- 100, Chautauqua County, New York, Grapes

0.780 0.300 0 15.00 1 1

4

0.33 1.00 1.00 172.80 5.80 3 15.00 600.0

1

1 0.25 90.00 100.00 3 94 91 93 0.00 150.0

1 3

0101 0106 01 10

0.50 0.50 0.50

.023 .023 .023

36

310548 220848 151048 1

310549 220849 151049 1

310550 220850 151050 1

310551 220851 151051 1

310552 220852 151052 1

310553 220853 151053 1

310554 220 854 151054 1

310555 220855 151055 1

310556 220856 151056 1

310557 220857 151057 1

310558 220858 151058 1

310559 220859 151059 1

310560 220860 151060 1

310561 220861 151061 1

310562 220862 151062 1

310563 220863 151063 1

310564 220864 151064 1

310565 220865 151065 1

310566 220866 151066 1

310567 220867 151067 1

310568 220868 151068 1

310569 220869 1510 69 1

310570 220870 151070 1

310571 220871 151071 1

310572 220872 151072 1

310573 220873 151073 1

310574 220874 151074 1

310575 220875 151075 1

310576 220876 151076 1

310577 220877 151077 1

310578 220878 151078 1

310579 220879 151079 1

310580 220880 151080 1

310581 220881 151081 1

310582 220882 151082 1

310583 220883 151083 1

Application Schedule: 0.2 lb a.i./acre; aerial spray, 95% effic. w/16% drift

***(early

- mid bloom, prior bunch closing, begin fruit ripening, +5 apps. prior to harvest)***

184 1 0 0

Zoxamide

140661 0 2 0.00 0.22 0.95 0.16

010861 0 2 0.00 0.22 0.95 0.16

## 71 220861 0 2 0.00 0.22 0.95 0.16

290861 0 2 0.00 0.22 0.95 0.16

050961 0 2 0.00 0.22 0.95 0.16

120961 0 2 0.00 0.22 0.95 0.16

190961 0 2 0.00 0.22 0.95 0.16

011061 0 2 0.00 0.22 0.95 0.16

140662 0 2 0.00 0.22 0.95 0.16

010 862 0 2 0.00 0.22 0.95 0.16

220862 0 2 0.00 0.22 0.95 0.16

290862 0 2 0.00 0.22 0.95 0.16

050962 0 2 0.00 0.22 0.95 0.16

120962 0 2 0.00 0.22 0.95 0.16

190962 0 2 0.00 0.22 0.95 0.16

011062 0 2 0.00 0.22 0.95 0.16

140663 0 2 0 .00 0.22 0.95 0.16

010863 0 2 0.00 0.22 0.95 0.16

220863 0 2 0.00 0.22 0.95 0.16

290863 0 2 0.00 0.22 0.95 0.16

050963 0 2 0.00 0.22 0.95 0.16

120963 0 2 0.00 0.22 0.95 0.16

190963 0 2 0.00 0.22 0.95 0.16

011063 0 2 0.00 0.22 0.95 0.16

140664 0 2 0.00 0.22 0.95 0.16

010864 0 2 0.00 0.22 0.95 0.16

220864 0 2 0.00 0.22 0.95 0.16

290864 0 2 0.00 0.22 0.95 0.16

050964 0 2 0.00 0.22 0.95 0.16

120964 0 2 0.00 0.22 0.95 0.16

190964 0 2 0.00 0.22 0.95 0.16

011064 0 2 0.00 0.22 0.95 0.16

140665 0 2 0.00 0.22 0.95 0.16

010865 0 2 0.00 0.22 0.95 0.16

220865 0 2 0.00 0.22 0.95 0.16

290865 0 2 0.00 0.22 0.95 0.16

050965 0 2 0.00 0.22 0.95 0.16

120965 0 2 0.00 0.22 0.95 0.16

190965 0 2 0.00 0.22 0.95 0.16

011065 0 2 0.00 0.22 0.95 0.16

140666 0 2 0.00 0.22 0.95 0.16

010866 0 2 0.00 0.22 0.95 0.16

220866 0 2 0.00 0.22 0.95 0.16

290866 0 2 0.00 0.22 0.95 0.16

050966 0 2 0.00 0.22 0.95 0.16

120966 0 2 0.00 0.22 0.95 0.16

190966 0 2 0.00 0.22 0.95 0.16

011066 0 2 0.00 0.22 0.95 0.16

140667 0 2 0.00 0.22 0.95 0.16

010867 0 2 0.00 0.22 0.95 0.16

220867 0 2 0.00 0.22 0.95 0.16

290867 0 2 0.00 0.22 0.95 0.16

050967 0 2 0.00 0.22 0.95 0.16

120967 0 2 0.00 0.22 0.95 0.16

190967 0 2 0.00 0.22 0.95 0.16

011067 0 2 0.00 0.22 0.95 0.16

140668 0 2 0.00 0.22 0.95 0.16

010868 0 2 0.00 0.22 0.95 0.16

220868 0 2 0.00 0.22 0.95 0.16

290868 0 2 0.00 0.22 0.95 0.16

050968 0 2 0.00 0.22 0.95 0.16

120968 0 2 0.00 0.22 0.95 0.16

190968 0 2 0.00 0.22 0.95 0.16

011068 0 2 0.00 0.22 0.95 0.16

140669 0 2 0.00 0.22 0.95 0.16

010869 0 2 0.00 0.22 0.95 0.16

220869 0 2 0.00 0 .22 0.95 0.16

290869 0 2 0.00 0.22 0.95 0.16

050969 0 2 0.00 0.22 0.95 0.16

120969 0 2 0.00 0.22 0.95 0.16

## 72 190969 0 2 0.00 0.22 0.95 0.16

011069 0 2 0.00 0.22 0.95 0.16

140670 0 2 0.00 0.22 0.95 0.16

010870 0 2 0.00 0.22 0.95 0.16

220870 0 2 0.00 0.22 0.95 0.16

290870 0 2 0.00 0.22 0.95 0.16

050970 0 2 0.00 0.22 0.95 0.16

120970 0 2 0.00 0.22 0.95 0.16

190970 0 2 0.00 0.22 0.95 0.16

011070 0 2 0.00 0.22 0.95 0.16

140671 0 2 0.00 0.22 0.95 0.16

010871 0 2 0.00 0.22 0.95 0.16

220871 0 2 0.00 0.22 0.95 0.16

290871 0 2 0.00 0.22 0.95 0.16

050971 0 2 0.00 0.22 0.95 0.16

120971 0 2 0.00 0.22 0.95 0.16

190971 0 2 0.00 0.22 0.95 0.16

011071 0 2 0.00 0.22 0.95 0.16

140672 0 2 0.00 0.22 0.95 0.16

010872 0 2 0.00 0.22 0.95 0.16

220872 0 2 0.00 0.22 0.95 0.16

290872 0 2 0.00 0.22 0.95 0.16

050972 0 2 0.00 0.22 0.95 0.16

120972 0 2 0.00 0.22 0.95 0.16

190972 0 2 0.00 0.22 0.95 0.16

011072 0 2 0.00 0.22 0.95 0.16

140673 0 2 0.00 0.22 0.95 0.16

010873 0 2 0.00 0.22 0.95 0.16

220873 0 2 0.00 0.22 0.95 0.16

290873 0 2 0.00 0.22 0.95 0.16

050973 0 2 0.00 0.22 0.95 0.16

120973 0 2 0.00 0.22 0.95 0.16

190973 0 2 0.00 0.22 0.95 0.16

011073 0 2 0.00 0.22 0.95 0.16

140674 0 2 0.00 0.22 0.95 0.16

010874 0 2 0.00 0.22 0.95 0.16

220874 0 2 0.00 0.22 0.95 0.16

290874 0 2 0.00 0.22 0.95 0.16

050974 0 2 0.00 0.22 0.95 0.16

120974 0 2 0.00 0.22 0.95 0.16

190974 0 2 0.00 0.22 0.95 0.16

011074 0 2 0.00 0.22 0.95 0.16

140675 0 2 0.00 0.22 0.95 0.16

010875 0 2 0.00 0.22 0.95 0.16

220875 0 2 0.00 0.22 0.95 0.16

290875 0 2 0.00 0.22 0.95 0.16

050975 0 2 0.00 0.22 0.95 0.16

120975 0 2 0.00 0.22 0.95 0.16

190975 0 2 0.00 0.22 0.95 0.16

011075 0 2 0.00 0.22 0.95 0.16

140676 0 2 0.00 0.22 0.95 0.16

010876 0 2 0.00 0.22 0.95 0.16

220876 0 2 0.00 0.22 0.95 0.16

290876 0 2 0.00 0.22 0.95 0 .16

050976 0 2 0.00 0.22 0.95 0.16

120976 0 2 0.00 0.22 0.95 0.16

190976 0 2 0.00 0.22 0.95 0.16

011076 0 2 0.00 0.22 0.95 0.16

140677 0 2 0.00 0.22 0.95 0.16

010877 0 2 0.00 0.22 0.95 0.16

220877 0 2 0.00 0.22 0.95 0.16

290877 0 2 0.00 0.22 0.95 0.16

050977 0 2 0.00 0.22 0.95 0.16

120977 0 2 0.00 0.22 0.95 0.16

190977 0 2 0.00 0.22 0.95 0.16

011077 0 2 0.00 0.22 0.95 0.16

140678 0 2 0.00 0.22 0.95 0.16

010878 0 2 0.00 0.22 0.95 0.16

## 73 220878 0 2 0.00 0.22 0.95 0.16

290878 0 2 0.00 0.22 0.95 0.16

050978 0 2 0.00 0.22 0.95 0.16

120978 0 2 0.00 0.22 0.95 0.16

190978 0 2 0.00 0.22 0.95 0.16

011078 0 2 0.00 0.22 0.95 0.16

140679 0 2 0.00 0.22 0.95 0.16

010879 0 2 0.00 0.22 0.95 0.16

220879 0 2 0.00 0.22 0.95 0.16

290879 0 2 0.00 0.22 0.95 0.16

050979 0 2 0.00 0.22 0.95 0.16

120979 0 2 0.00 0.22 0.95 0.16

190979 0 2 0.00 0.22 0.95 0.16

011079 0 2 0.00 0.22 0.95 0.16

140680 0 2 0.00 0.22 0.95 0.16

010880 0 2 0.00 0.22 0.95 0.16

220880 0 2 0.00 0.22 0.95 0.16

290880 0 2 0.00 0.22 0.95 0.16

050980 0 2 0.00 0.22 0.95 0.16

120980 0 2 0.00 0.22 0.95 0.16

190980 0 2 0.00 0.22 0.95 0.16

011080 0 2 0.00 0.22 0.95 0.16

140681 0 2 0.00 0.22 0.95 0.16

010881 0 2 0.00 0.22 0.95 0.16

220881 0 2 0.00 0.22 0.95 0.16

290881 0 2 0.00 0.22 0.95 0.16

050981 0 2 0.00 0.22 0.95 0.16

120981 0 2 0.00 0.22 0.95 0.16

190981 0 2 0.00 0.22 0.95 0.16

011081 0 2 0.00 0.22 0.95 0.16

140682 0 2 0.00 0.22 0.95 0.16

010882 0 2 0.00 0.22 0.95 0.16

220882 0 2 0.00 0.22 0.95 0.16

290882 0 2 0.00 0.22 0.95 0.16

050982 0 2 0.00 0.22 0.95 0.16

120982 0 2 0.00 0.22 0.95 0.16

190982 0 2 0.00 0.22 0.95 0.16

011082 0 2 0.00 0.22 0.95 0.16

140683 0 2 0.00 0.22 0.95 0.16

010883 0 2 0.00 0.22 0.95 0.16

220883 0 2 0.00 0.22 0.95 0.16

290883 0 2 0.00 0.22 0.95 0.16

050983 0 2 0.00 0.22 0.95 0.16

120983 0 2 0.00 0.22 0.95 0.16

190983 0 2 0.00 0.22 0.95 0.16

011083 0 2 0.00 0.22 0.95 0.16

0.0 3 0.0

0.00 0.00 0.50

Hornell Silt Loam; Hydrologic Group D;

100.00 0.0 0 0 1 0 0 0 0 0 0

0.0 0.0 0.0

4 1345.

3

1 18.00 1.400 0.322 0.000 0.000 0.00

.01791 .01791 0.000

0.1 0.322 0.162 1.740 0.0

2 66.00 1.500 0.310 0.000 0.000 0.00

.01791 . 01791 0.000

1.0 0.310 0.200 0.174 0.0

3 16.00 1.950 0.260 0.000 0.000 0.00

.01791 .01791 0.000

1.0 0.260 0.190 0.116 0.0

0

YEAR 5 YEAR 5 YEAR 5 1

1

1

-----

6 DAY

PRCP TSER 0 0

## 74 RUNF TSER 0 0

ESLS TSER 0 0 1.0E3

RFLX TSER 0 0 1.0E5

EFLX TSER 0 0 1.0E5

RZFX TSER 0 0 1.0E5

1Exposure Analysis Modeling System

-- EXAMS Version 2.97, Mode 3

Chemical: 1) zoxamide

--------------------------------------------------------------- Table 1.01.1 Chemical input data for neutral mo lecule (Sp.#1).

*** Chemical

- specific data: SET via "entry( 1)"

MWT: 3.36E+02 VAPR: 1.00E

- 07 HENRY: 6.59E

- 03 KOW:

KVO: EVPR: EHEN: KOC: 1.35E+03

*** Ion

- specific data: "entry(1, 1)"

SOL: 6.80 KPB: KPS:

ESOL: KPDOC:

*** Reactivity of dissolved species: SET via "entry(1, 1, 1)"

KAH: EAH: KNH: ENH:

KBH: EB H: KRED: ERED:

KBACW: 2.45E

- 03 QTBAW: 2.00 KBACS: 9.89E

- 04 QTBAS: 2.00

*** Reactivity of solids

- sorbed species: "entry(2, 1, 1)"

KAH: EAH: KNH: ENH:

KBH: EBH: KRED: ERED:

KBACW: 2.45E

- 03 QTBAW: 2.00 KBACS: 9.89E

- 04 QTBAS: 2.00

*** Reactivity of "DOC"

- complexed species: "entry(3, 1, 1)"

KAH: EAH: KNH: ENH:

KBH: EBH: KRED: ERED:

KBACW: 2.45E

- 03 QTBAW: 2.00 KBACS: 9.89E

- 04 QTBAS: 2.00

*** Reactivity of biosorbed species: "entry(4, 1, 1)"

KBACW: 2.45E

- 03 QTBAW: 2.00 KBACS: 9.89E

- 04 QTBAS: 2 .00

**Zoxamide PRZM and EXAMS New York grape crop output for use in Index Reservoir/Percent Crop Area**

**calculations.**

WATER COLUMN DISSOLVED CONCENTRATION (PPB)

YEAR PEAK 96 HOUR 21 DAY 60 DAY 90 DAY YEARLY

1961 4.969 3 .062 1.537 0.997 0.881 0.342

1962 13.230 8.466 3.670 1.907 1.673 0.640

1963 7.261 5.453 2.307 1.115 0.908 0.392

1964 5.994 3.492 1.521 0.958 0.917 0.458

1965 9.315 6.177 2.221 1.385 1.213 0.504

1966 4.407 2.858 1.664 1.149 1.066 0.495

1967 9.468 6.145 2.826 1.857 1.565 0.571

1968 4.064 2.862 1.254 1.109 0.940 0.41 2

1969 3.758 2.884 1.270 1.020 0.859 0.392

1970 12.720 7.845 4.589 2.343 1.770 0.648

1971 7.542 5.649 2.343 1.814 1.388 0.526

1972 7.793 4.972 3.094 1.609 1.317 0.555

1973 3.545 2.399 1.417 0.981 0.858 0.345

1974 3.417 2.407 1.390 0.970 0.922 0.427

1975 10.650 7.747 3.439 1.897 1.41 8 0.573

1976 5.926 4.248 2.001 1.568 1.187 0.484

1977 18.140 13.870 8.442 3.922 3.047 1.127

1978 9.614 6.590 3.682 2.108 1.742 0.635

1979 40.530 24.970 8.629 4. 960 3.496 1.130

1980 12.660 8.819 3.378 2.742 2.283 0.818

1981 15.660 10.380 3.806 1.939 1.507 0.540

1982 6.400 3.987 2.186 1.503 1.334 0.515

1983 20.400 12.570 5.165 2.693 2.116 0.723

SORTED FOR PLOTTING

PROB PEAK 96 HOUR 21 DAY 60 DAY 90 DAY YEARLY

0.042 40.530 24.970 8.629 4.960 3.496 1.130

0.083 20.400 13.870 8.442 3.922 3.047 1.127

0.125 18.140 12.570 5.165 2.742 2.283 0.818

0.167 15.660 10.380 4.589 2.693 2.116 0.723

## 75 0.208 13.230 8.819 3.806 2.343 1.770 0.648

0.250 12.720 8.466 3.682 2.108 1.742 0.640

0.292 12.660 7.845 3.670 1.939 1.673 0.635

0.333 10.650 7.747 3.439 1.907 1.565 0.573

0.375 9.614 6.590 3.378 1. 897 1.507 0.571

0.417 9.468 6.177 3.094 1.857 1.418 0.555

0.458 9.315 6.145 2.826 1.814 1.388 0.540

0.500 7.793 5.649 2.343 1.609 1.334 0.526

0.542 7.542 5.453 2.307 1.568 1.317 0.515

0.583 7.261 4.972 2.221 1.503 1.213 0.504

0.625 6.400 4.248 2.186 1.385 1.187 0.495

0.667 5.994 3.987 2.001 1.149 1.066 0.484

0.708 5.926 3.492 1.664 1.115 0.940 0.458

0.750 4.969 3.062 1.537 1.109 0.922 0.427

0.792 4.407 2.884 1.521 1.020 0.917 0.412

0 .833 4.064 2.862 1.417 0.997 0.908 0.392

0.875 3.758 2.858 1.390 0.981 0.881 0.392

0.917 3.545 2.407 1.270 0.970 0.859 0.345

0.958 3.417 2.399 1.254 0.95 8 0.858 0.342

1/10 19.496 13.350 7.131 3.450 2.741 1.003

MEAN OF ANNUAL VALUES = 0.576

STANDARD DEVIATION OF ANNUAL VALUES = 0.210

UPPER 90% CONFIDENCE LIMIT ON MEAN = 0.642

**Zoxamide PRZM and EXAMS Maine potato crop input for use in index reservoir/PCA calculations.** 

*** PRZM 3.1 Input Data File coverted from PRZM 2.3; S.ABEL ***

*** MEPoIR.INP created October 26, 2000 ***

*** Modeler: M. Corbin ***

*** Index Reservoir and PCA Scenario for DW Assessment***

*** Assume 4% slope, conventional tillage with crop residue left ***

*** on the field after harvest ***

*** Manning's N value for planted across slope poor stand at ***

*** 20% maturity (for small grains) ***

*** Application by aerial spra y ***

*** PCA for potatoes not available, use default PCA of 0.87 ***

Zoxamide

Conant Silt Loam MLRA M

- 143, Arastook County, ME

0.770 0.150 0 12.50 1 3

4

0.28 0.44 1.00 172.80 5.80 3 4.00 600.00

1

1 0.10 30.00 90.00 3 91 85 88 0.00 60.0

1 3

0101 0105 0109

0.43 0.27 0.43

.018 .018 .018

36

050548 080948 180948 1

050549 080949 180949 1

050550 080950 180950 1

050551 080951 180951 1

050552 080952 180952 1

050553 080953 180953 1

050554 080954 180954 1

050555 080955 180955 1

050556 080956 180956 1

050557 080957 180957 1

050558 080958 180958 1

050559 080959 180959 1

050560 080960 180960 1

050561 080961 180961 1

050562 080962 180962 1

050563 080963 180963 1

## 76 050564 080964 180964 1

050565 080965 180965 1

050566 080966 180966 1

050567 080967 180967 1

050568 080968 180968 1

050569 080969 180969 1

050570 080970 180970 1

050571 080971 180971 1

050572 080972 180972 1

050573 080973 180973 1

050574 080974 180974 1

050575 080975 180975 1

050576 080976 180976 1

050577 080977 180977 1

050578 080978 180978 1

050579 080979 180979 1

050580 080980 180980 1

050581 080981 180981 1

050582 080982 180982 1

050583 080983 180983 1

Application Schedule: Aerial Spray @ 0.22 kgs a.i/ha, 8 times @ 5 day intervals,

288 1 0 0

Zoxami de:

060548 0 2 0.0 0.22 0.95 0.16

110548 0 2 0.0 0.22 0.95 0.16

160548 0 2 0.0 0.22 0.95 0.16

210548 0 2 0.0 0.22 0.95 0.16

260548 0 2 0.0 0.22 0.95 0.16

310548 0 2 0.0 0.22 0.95 0.16

050648 0 2 0.0 0.22 0.95 0.16

11064 8 0 2 0.0 0.22 0.95 0.16

060549 0 2 0.0 0.22 0.95 0.16

110549 0 2 0.0 0.22 0.95 0.16

160549 0 2 0.0 0.22 0.95 0.16

210549 0 2 0.0 0.22 0.95 0.16

260549 0 2 0.0 0.22 0.95 0.16

310549 0 2 0.0 0.22 0.95 0.16

050649 0 2 0.0 0.22 0.95 0.16

110649 0 2 0.0 0.22 0.95 0.16

060550 0 2 0.0 0.22 0.95 0.16

110550 0 2 0.0 0.22 0.95 0.16

160550 0 2 0.0 0.22 0.95 0.16

210550 0 2 0.0 0.22 0.95 0.16

260550 0 2 0.0 0.22 0.95 0.16

310550 0 2 0.0 0.22 0.95 0.16

050650 0 2 0.0 0.22 0.95 0.16

110650 0 2 0.0 0.22 0.95 0.16

060551 0 2 0.0 0.22 0.95 0.16

110551 0 2 0.0 0.22 0.95 0.16

160551 0 2 0.0 0.22 0.95 0.16

210551 0 2 0.0 0.22 0.95 0.16

260551 0 2 0.0 0.22 0.95 0.16

310551 0 2 0.0 0.22 0.95 0.16

050651 0 2 0.0 0.22 0.95 0.16

110651 0 2 0.0 0.22 0.95 0.16

060552 0 2 0.0 0.22 0.95 0.16

110552 0 2 0.0 0.22 0.95 0.16

160552 0 2 0.0 0.22 0.95 0.16

210552 0 2 0.0 0 .22 0.95 0.16

260552 0 2 0.0 0.22 0.95 0.16

310552 0 2 0.0 0.22 0.95 0.16

050652 0 2 0.0 0.22 0.95 0.16

110652 0 2 0.0 0.22 0.95 0.16

060553 0 2 0.0 0.22 0.95 0.16

110553 0 2 0.0 0.22 0.95 0.16

160553 0 2 0.0 0.22 0.95 0.16

210553 0 2 0.0 0.22 0.95 0.16

260553 0 2 0.0 0.22 0.95 0.16

## 77 310553 0 2 0.0 0.22 0.95 0.16

050653 0 2 0.0 0.22 0.95 0.16

110653 0 2 0.0 0.22 0.95 0.16

060554 0 2 0.0 0.22 0.95 0.16

110554 0 2 0.0 0.22 0.95 0.16

160554 0 2 0.0 0.22 0.95 0.16

210554 0 2 0.0 0.22 0.95 0.16

260554 0 2 0.0 0.22 0.95 0.16

310554 0 2 0.0 0.22 0.95 0.16

050654 0 2 0.0 0.22 0.95 0.16

110654 0 2 0.0 0.22 0.95 0.16

060555 0 2 0.0 0. 22 0.95 0.16

110555 0 2 0.0 0.22 0.95 0.16

160555 0 2 0.0 0.22 0.95 0.16

210555 0 2 0.0 0.22 0.95 0.16

260555 0 2 0.0 0.22 0.95 0.16

310555 0 2 0.0 0.22 0.95 0.16

050655 0 2 0.0 0.22 0.95 0.16

110655 0 2 0.0 0.22 0.95 0.16

060556 0 2 0.0 0.22 0.95 0.16

110556 0 2 0.0 0.22 0.95 0.16

160556 0 2 0.0 0.22 0.95 0.16

210556 0 2 0.0 0.22 0.95 0.16

260556 0 2 0.0 0.22 0.95 0.16

310556 0 2 0.0 0.22 0.95 0.16

050656 0 2 0.0 0.22 0.95 0.16

110656 0 2 0.0 0.22 0.95 0.16

060557 0 2 0.0 0.22 0.95 0.16

110557 0 2 0.0 0.22 0.95 0.16

160557 0 2 0.0 0.22 0.95 0.16

210557 0 2 0.0 0.22 0.95 0.16

260557 0 2 0.0 0.22 0.95 0.16

310557 0 2 0.0 0.22 0.95 0.16

050657 0 2 0.0 0.22 0.95 0.16

110657 0 2 0.0 0.22 0.95 0.16

060558 0 2 0.0 0.22 0.95 0.16

110558 0 2 0.0 0.22 0.95 0.16

160558 0 2 0.0 0.22 0.95 0.16

210558 0 2 0.0 0.22 0.95 0.16

260558 0 2 0.0 0.22 0.95 0.16

310558 0 2 0.0 0 .22 0.95 0.16

050658 0 2 0.0 0.22 0.95 0.16

110658 0 2 0.0 0.22 0.95 0.16

060559 0 2 0.0 0.22 0.95 0.16

110559 0 2 0.0 0.22 0.95 0.16

160559 0 2 0.0 0.22 0.95 0.16

210559 0 2 0.0 0.22 0.95 0.16

260559 0 2 0.0 0.22 0.95 0. 16

310559 0 2 0.0 0.22 0.95 0.16

050659 0 2 0.0 0.22 0.95 0.16

110659 0 2 0.0 0.22 0.95 0.16

060560 0 2 0.0 0.22 0.95 0.16

110560 0 2 0.0 0.22 0.95 0.16

160560 0 2 0.0 0.22 0.95 0.16

210560 0 2 0.0 0.22 0.95 0.16

260560 0 2 0.0 0.22 0.95 0.16

310560 0 2 0.0 0.22 0.95 0.16

050660 0 2 0.0 0.22 0.95 0.16

110660 0 2 0.0 0.22 0.95 0.16

060561 0 2 0.0 0.22 0.95 0.16

110561 0 2 0.0 0.22 0.95 0.16

160561 0 2 0.0 0.22 0.95 0.16

210561 0 2 0.0 0.22 0.95 0.16

260561 0 2 0.0 0.22 0.95 0.16

310561 0 2 0.0 0.22 0.95 0.16

050661 0 2 0.0 0.22 0.95 0.16

110661 0 2 0.0 0.22 0.95 0.16

060562 0 2 0.0 0.22 0.95 0.16

## 78 110562 0 2 0.0 0.22 0.95 0.16

160562 0 2 0.0 0.22 0.95 0.16

210562 0 2 0.0 0.22 0.95 0.16

260562 0 2 0.0 0.22 0.95 0.16

310562 0 2 0.0 0.22 0.95 0.16

050662 0 2 0.0 0.22 0.95 0.16

110662 0 2 0.0 0.22 0.95 0.16

060563 0 2 0.0 0.22 0.95 0.16

110563 0 2 0.0 0.22 0.95 0.16

160563 0 2 0.0 0.22 0.95 0.16

210563 0 2 0.0 0.22 0.95 0.16

260563 0 2 0.0 0.22 0.95 0.16

310563 0 2 0.0 0.22 0.95 0.16

050663 0 2 0.0 0.22 0.95 0.16

110663 0 2 0.0 0.22 0.95 0.16

060564 0 2 0.0 0.22 0.95 0.16

110564 0 2 0.0 0.22 0.95 0.16

160564 0 2 0.0 0.22 0.95 0.16

210564 0 2 0.0 0.22 0.95 0.16

260564 0 2 0.0 0.22 0.95 0.16

310564 0 2 0.0 0.22 0.95 0.16

050664 0 2 0.0 0.22 0.95 0.16

110664 0 2 0.0 0.22 0.95 0.16

060565 0 2 0.0 0.22 0.95 0.16

110565 0 2 0.0 0.22 0.95 0.16

160565 0 2 0.0 0.22 0.95 0.16

210565 0 2 0.0 0.22 0.95 0.16

260565 0 2 0.0 0.22 0.95 0.16

310565 0 2 0.0 0.22 0.95 0.16

050665 0 2 0.0 0.22 0.95 0.16

110665 0 2 0.0 0.22 0.95 0.16

060566 0 2 0.0 0.22 0.95 0.16

110566 0 2 0.0 0.22 0.95 0.16

160566 0 2 0.0 0.22 0.95 0.16

210566 0 2 0.0 0.22 0.95 0.16

260566 0 2 0.0 0.22 0.95 0.16

310566 0 2 0.0 0.22 0.95 0.16

050666 0 2 0.0 0.22 0.95 0.16

110666 0 2 0.0 0.22 0.95 0.16

060567 0 2 0.0 0.22 0.95 0.16

110567 0 2 0.0 0.22 0.95 0.16

160567 0 2 0.0 0.22 0.95 0.16

210567 0 2 0.0 0.22 0.95 0.16

260567 0 2 0.0 0.22 0.95 0.16

310567 0 2 0.0 0.22 0.95 0.16

050667 0 2 0.0 0.22 0.95 0.16

110667 0 2 0.0 0.22 0.95 0.16

060568 0 2 0.0 0.22 0.95 0.16

110568 0 2 0.0 0.22 0.95 0.16

160568 0 2 0.0 0.22 0.95 0.16

210568 0 2 0.0 0.22 0.95 0.16

260568 0 2 0.0 0. 22 0.95 0.16

310568 0 2 0.0 0.22 0.95 0.16

050668 0 2 0.0 0.22 0.95 0.16

110668 0 2 0.0 0.22 0.95 0.16

060569 0 2 0.0 0.22 0.95 0.16

110569 0 2 0.0 0.22 0.95 0.16

160569 0 2 0.0 0.22 0.95 0.16

210569 0 2 0.0 0.22 0.95 0.16

260569 0 2 0.0 0.22 0.95 0.16

310569 0 2 0.0 0.22 0.95 0.16

050669 0 2 0.0 0.22 0.95 0.16

110669 0 2 0.0 0.22 0.95 0.16

060570 0 2 0.0 0.22 0.95 0.16

110570 0 2 0.0 0.22 0.95 0.16

160570 0 2 0.0 0.22 0.95 0.16

210570 0 2 0.0 0.22 0.95 0.16

260570 0 2 0.0 0.22 0.95 0.16

## 79 310570 0 2 0.0 0.22 0.95 0.16

050670 0 2 0.0 0.22 0.95 0.16

110670 0 2 0.0 0.22 0.95 0.16

060571 0 2 0.0 0.22 0.95 0.16

110571 0 2 0.0 0. 22 0.95 0.16

160571 0 2 0.0 0.22 0.95 0.16

210571 0 2 0.0 0.22 0.95 0.16

260571 0 2 0.0 0.22 0.95 0.16

310571 0 2 0.0 0.22 0.95 0.16

050671 0 2 0.0 0.22 0.95 0.16

110671 0 2 0.0 0.22 0.95 0.16

060572 0 2 0.0 0.22 0.95 0 .16

110572 0 2 0.0 0.22 0.95 0.16

160572 0 2 0.0 0.22 0.95 0.16

210572 0 2 0.0 0.22 0.95 0.16

260572 0 2 0.0 0.22 0.95 0.16

310572 0 2 0.0 0.22 0.95 0.16

050672 0 2 0.0 0.22 0.95 0.16

110672 0 2 0.0 0.22 0.95 0.16

060573 0 2 0.0 0.22 0.95 0.16

110573 0 2 0.0 0.22 0.95 0.16

160573 0 2 0.0 0.22 0.95 0.16

210573 0 2 0.0 0.22 0.95 0.16

260573 0 2 0.0 0.22 0.95 0.16

310573 0 2 0.0 0.22 0.95 0.16

050673 0 2 0.0 0.22 0.95 0.16

110673 0 2 0.0 0.22 0.95 0.16

060574 0 2 0.0 0.22 0.95 0.16

110574 0 2 0.0 0.22 0.95 0.16

160574 0 2 0.0 0.22 0.95 0.16

210574 0 2 0.0 0.22 0.95 0.16

260574 0 2 0.0 0.22 0.95 0.16

310574 0 2 0.0 0.22 0.95 0.16

050674 0 2 0.0 0.22 0.95 0.16

110674 0 2 0.0 0.22 0.95 0.16

060575 0 2 0.0 0.22 0.95 0.16

110575 0 2 0.0 0.22 0.95 0.16

160575 0 2 0.0 0.22 0.95 0.16

210575 0 2 0.0 0.22 0.95 0.16

260575 0 2 0.0 0.22 0.95 0.16

310575 0 2 0.0 0.22 0.95 0.16

050675 0 2 0.0 0.22 0.95 0.16

110675 0 2 0.0 0.22 0.95 0.16

060576 0 2 0.0 0.22 0.95 0.16

110576 0 2 0.0 0.22 0.95 0.16

160576 0 2 0.0 0.22 0.95 0.16

210576 0 2 0.0 0.22 0.95 0.16

260576 0 2 0.0 0.22 0.95 0.16

310576 0 2 0.0 0.22 0.95 0.16

050676 0 2 0.0 0.22 0.95 0.16

110676 0 2 0.0 0.22 0.95 0.16

060577 0 2 0.0 0.22 0.95 0.16

110577 0 2 0.0 0.22 0.95 0.16

160577 0 2 0.0 0.22 0.95 0.16

210577 0 2 0.0 0 .22 0.95 0.16

260577 0 2 0.0 0.22 0.95 0.16

310577 0 2 0.0 0.22 0.95 0.16

050677 0 2 0.0 0.22 0.95 0.16

110677 0 2 0.0 0.22 0.95 0.16

060578 0 2 0.0 0.22 0.95 0.16

110578 0 2 0.0 0.22 0.95 0.16

160578 0 2 0.0 0.22 0.95 0. 16

210578 0 2 0.0 0.22 0.95 0.16

260578 0 2 0.0 0.22 0.95 0.16

310578 0 2 0.0 0.22 0.95 0.16

050678 0 2 0.0 0.22 0.95 0.16

110678 0 2 0.0 0.22 0.95 0.16

060579 0 2 0.0 0.22 0.95 0.16

## 80 110579 0 2 0.0 0.22 0.95 0.16

160579 0 2 0.0 0.22 0.95 0.16

210579 0 2 0.0 0.22 0.95 0.16

260579 0 2 0.0 0.22 0.95 0.16

310579 0 2 0.0 0.22 0.95 0.16

050679 0 2 0.0 0.22 0.95 0.16

110679 0 2 0.0 0.22 0.95 0.16

060580 0 2 0.0 0.22 0.95 0.16

110580 0 2 0.0 0.22 0.95 0.16

160580 0 2 0.0 0.22 0.95 0.16

210580 0 2 0.0 0.22 0.95 0.16

260580 0 2 0.0 0.22 0.95 0.16

310580 0 2 0.0 0.22 0.95 0.16

050680 0 2 0.0 0.22 0.95 0.16

110680 0 2 0.0 0.22 0.95 0.16

060581 0 2 0.0 0.22 0.95 0.16

110581 0 2 0.0 0.22 0.95 0.16

160581 0 2 0.0 0.22 0.95 0.16

210581 0 2 0.0 0.22 0.95 0.16

260581 0 2 0.0 0.22 0.95 0.16

310581 0 2 0.0 0.22 0.95 0.16

050681 0 2 0.0 0.22 0.95 0.16

110681 0 2 0.0 0.22 0.95 0 .16

060582 0 2 0.0 0.22 0.95 0.16

110582 0 2 0.0 0.22 0.95 0.16

160582 0 2 0.0 0.22 0.95 0.16

210582 0 2 0.0 0.22 0.95 0.16

260582 0 2 0.0 0.22 0.95 0.16

310582 0 2 0.0 0.22 0.95 0.16

050682 0 2 0.0 0.22 0.95 0.16

110682 0 2 0.0 0.22 0.95 0.16

060583 0 2 0.0 0.22 0.95 0.16

110583 0 2 0.0 0.22 0.95 0.16

160583 0 2 0.0 0.22 0.95 0.16

210583 0 2 0.0 0.22 0.95 0.16

260583 0 2 0.0 0.22 0.95 0.16

310583 0 2 0.0 0.22 0.95 0.16

050683 0 2 0.0 0.22 0.95 0.16

110683 0 2 0.0 0.22 0.95 0.16

0.0 3

0.0 0.0 0.5

Soil Series: Conant Silt Loam

100.00 0 0 1 0 0 0 0 0 0

0.0 0.00 0.00

4 1345.0

4

1 10.00 1.250 0.341 0.000 0.000 0.000

.01791 .01791 0.000

0.1 0.341 0.121 4.640 0.0

2 16.00 1.250 0.341 0.000 0.000 0.000

.01791 .01791 0.000

1.0 0.341 0.121 4.640 0.0

3 64.00 1.400 0.266 0.000 0.000 0.000

.01791 .01791 0.000

1.0 0.266 0.116 0.174 0.0

4 10.00 1.600 0.261 0.000 0.000 0.000

. 01791 .01791 0.000

1.0 0.261 0.111 0.116 0.0

0

WATR YEAR 10 PEST YEAR 10 CONC YEAR 10 1

1

1

-----

6 DAY

PRCP TSER 0 0

RUNF TSER 0 0

ESLS TSER 0 0 1.0E3

RFLX TSER 0 0 1.0E5

EFLX TSER 0 0 1.0E5

## 81 RZFX TSER 0 0 1.0E5

1Exposure Analysis Modeling System

-- EXAMS Version 2.97, Mode 3

Chemical: 1) zoxamide

----------------------------------------- ---------------------- Table 1.01.1 Chemical input data for neutral molecule (Sp.#1).

*** Chemical

- specific data: SET via "entry( 1)"

MWT: 3.36E+02 VAPR: 1.00E

- 07 HENRY: 6.59E

- 03 KOW:

KVO: EVPR: EHEN: KOC: 1.35E+03

*** Ion

- specific data: "entry(1, 1)"

SOL: 6.80 KPB: KPS:

ESOL: KPDOC:

*** Reactivity of diss olved species: SET via "entry(1, 1, 1)"

KAH: EAH: KNH: ENH:

KBH: EBH: KRED: ERED:

KBACW: 2.45E

- 03 QTBAW: 2.00 KBACS: 9.89E

- 04 QTBAS: 2.00

*** Reactivity of solids

- sorbed species: "entry(2, 1, 1)"

KAH: EAH: KNH: ENH:

KBH: EBH: KRED: ERED:

KBACW: 2.45E

- 03 QTBAW: 2.00 KBACS: 9.89E

- 04 QTBAS: 2.00

*** Reactivity of "DOC"

- complexed species: "entry(3, 1, 1)"

KAH: EAH: KNH: ENH:

KBH: EBH: KRED: ERED:

KBACW: 2.45E

- 03 QTBAW: 2.00 KBACS: 9.89E

- 04 QTBAS: 2.00

*** Reacti vity of biosorbed species: "entry(4, 1, 1)"

KBACW: 2.45E

- 03 QTBAW: 2.00 KBACS: 9.89E

- 04 QTBAS: 2.00

**Zoxamide PRZM and EXAMS Maine potato crop output for use in Index Reservoir/PCA calculations.**

WATER COLUMN DISSOLVED CONCENTRATION (P PB)

YEAR PEAK 96 HOUR 21 DAY 60 DAY 90 DAY YEARLY

1948 1.811 1.156 1.053 0.721 0.557 0.173

1949 1.811 1.155 1.049 0.660 0.503 0.158

1950 1.819 1.218 1.074 0.674 0.459 0.140

1951 1.811 1.155 1.049 0.679 0.511 0.147

1952 5.233 3.136 1.587 0.911 0.625 0.183

1953 1.829 1.178 1.066 0.740 0.51 3 0.174

1954 2.064 1.471 1.161 0.741 0.496 0.158

1955 8.718 5.228 2.756 1.323 0.912 0.296

1956 4.774 3.055 1.732 0.940 0.668 0.198

1957 6.329 3.954 1.309 1. 139 0.845 0.262

1958 2.211 1.630 1.198 0.750 0.506 0.150

1959 3.185 1.909 1.095 0.818 0.547 0.157

1960 3.066 1.839 1.284 0.950 0.661 0.199

1961 1.913 1.243 1.094 0.775 0.549 0.159

1962 1.824 1.166 1.054 0.718 0.555 0.168

1963 1.811 1.156 1.051 0.662 0.459 0.138

1964 2.197 1.503 1.299 0.782 0.537 0.171

1965 4.165 2.509 1.431 0.858 0.580 0.185

1966 1.944 1.203 1.093 0.692 0.462 0.143

1967 1.840 1.176 1.063 0.694 0.509 0.151

1968 1.972 1.261 1.090 0.705 0.478 0.135

1969 3.024 2.109 1.352 0.899 0.602 0.172

1970 1.976 1.381 1.142 0.794 0.551 0.165

1971 1.811 1.156 1.052 0.683 0.483 0.152

1972 8.428 5.051 1.883 1.154 0.845 0 .232

1973 5.003 3.203 1.797 1.214 0.862 0.256

1974 4.806 2.881 1.180 0.993 0.675 0.193

1975 1.811 1.155 1.050 0.660 0.493 0.145

1976 3.505 2.243 1.614 1.005 0.678 0.203

1977 1.884 1.155 1.049 0.660 0.453 0.154

1978 1.910 1.219 1.072 0.716 0.491 0.143

1979 2.309 1.523 1.179 0.719 0.48 0 0.151

1980 2.611 1.511 1.049 0.662 0.600 0.179

1981 2.767 1.845 1.338 0.791 0.530 0.185

1982 2.761 1.935 1.325 0.926 0.665 0.202

## 82 1983 4.658 3.184 1.654 0. 898 0.630 0.220

SORTED FOR PLOTTING

PROB PEAK 96 HOUR 21 DAY 60 DAY 90 DAY YEARLY

0.027 8.718 5.228 2.756 1.323 0.912 0.296

0.054 8.428 5.051 1.883 1.214 0.862 0.262

0.081 6.329 3.954 1.797 1.154 0.845 0.256

0.108 5.233 3.203 1.732 1.139 0.845 0.232

0.135 5.003 3.184 1.654 1.005 0.678 0.220

0.162 4 .806 3.136 1.614 0.993 0.675 0.203

0.189 4.774 3.055 1.587 0.950 0.668 0.202

0.216 4.658 2.881 1.431 0.940 0.665 0.199

0.243 4.165 2.509 1.352 0.926 0.66 1 0.198

0.270 3.505 2.243 1.338 0.911 0.630 0.193

0.297 3.185 2.109 1.325 0.899 0.625 0.185

0.324 3.066 1.935 1.309 0.898 0.602 0.185

0.351 3.024 1.909 1.299 0.858 0.600 0.183

0.378 2.767 1.845 1.284 0.818 0.580 0.179

0.405 2.761 1.839 1.198 0.794 0.557 0.174

0.432 2.611 1.630 1.180 0.791 0.555 0.173

0.459 2.309 1.523 1.179 0.782 0.551 0.172

0.486 2.211 1.511 1.161 0.775 0.549 0.171

0.514 2.197 1.503 1.142 0.750 0.547 0.168

0.541 2.064 1.471 1.095 0.741 0.537 0.165

0.568 1.976 1.381 1.094 0.740 0.530 0.159

0.595 1.972 1.261 1.093 0.721 0.513 0.158

0.622 1.944 1.243 1.090 0.719 0.5 11 0.158

0.649 1.913 1.219 1.074 0.718 0.509 0.157

0.676 1.910 1.218 1.072 0.716 0.506 0.154

0.703 1.884 1.203 1.066 0.705 0.503 0.152

0.730 1.840 1.178 1.063 0.694 0.496 0.151

0.757 1.829 1.176 1.054 0.692 0.493 0.151

0.784 1.824 1.166 1.053 0.683 0.491 0.150

0.811 1.819 1.156 1.052 0.679 0.483 0.147

0.838 1.811 1.156 1.051 0.674 0.480 0.145

0.865 1.811 1.156 1.050 0.662 0.478 0.143

0.892 1.811 1.155 1.049 0.662 0.462 0.143

0.919 1.811 1.155 1 .049 0.660 0.459 0.140

0.946 1.811 1.155 1.049 0.660 0.459 0.138

0.973 1.811 1.155 1.049 0.660 0.453 0.135

1/10 5.562 3.428 1.752 1.144 0.845 0.239

MEAN OF ANNUAL VALUES = 0.178

STANDARD DEVIATION OF ANNUAL VALUES = 0.037

UPPER 90% CONFIDENCE LIMIT ON MEAN = 0.187

**Zoxamide Residues PRZM and EXAMS New York grapes crop input for use in index reservoir/PCA calculations**

***PRZM 3.1 Input Data File converted from PRZM 2.3***

***Modeler M. Corbin***

***IRNYGrp.INP, modified from NYGrape1.inp October 31, 2000; Chautauqua County, NY.***

***Chautauqua County has highest acreage of Grapes in NY (3rd highest state in US) ***

***Erie, P A Weather Station used

- closest to county, Grapes with grass cover ***

***Soil Hornell, Hydrologic Group D ***

***Application timing provided by Phillip Throop of Cornell U. and Fredonia Regional Extension***

***Office, Viticulture Specialist: pthroop@cce .cornell.edu; (716) 672

- 2191.***

***All values are average of 15 years of data collection for early

- mid bloom, fruit***

***ripening (veraison), and prior to harvest. Prior to bunch closing is assumed to accur***

***at August 1, this benchmark is not a comm on factor to measure and will vary according to

environmental***

***conditions and type of grape. This scenario is based on the Concord variety.***

***Emergence, maturation and harvest are set as early bloom, veraison and harvest.***

***Assume poor grass c overage under vines and overland flow***

***Pesticide is aerial spray applied***

*** set up for Koc input (see records 20 and 30)***

## 83 ***Meteorology Data using MET100.met (Data from 1961 to 1983)***

Zoxamide

Hornell silt loam; MLRA L

- 100, Chautauqua County, New York, Grapes

0.780 0.300 0 15.00 1 1

4

0.33 1.00 1.00 172.80 5.80 3 15.00 600.0

1

1 0.25 90.00 100.00 3 94 91 93 0.00 150.0

1 3

0101 0106 0110

0.50 0.50 0.50

.023 .023 .023

36

310548 220848 151048 1

310549 220849 151049 1

310550 220850 151050 1

310551 220851 151051 1

310552 220852 151052 1

310553 220853 151053 1

310554 220854 15 1054 1

310555 220855 151055 1

310556 220856 151056 1

310557 220857 151057 1

310558 220858 151058 1

310559 220859 151059 1

310560 220860 151060 1

310561 220861 151061 1

310562 220862 151062 1

310563 220863 151063 1

310564 220864 151064 1

310565 220865 151065 1

310566 220866 151066 1

310567 220867 151067 1

310568 220868 151068 1

310569 220869 1510 69 1

310570 220870 151070 1

310571 220871 151071 1

310572 220872 151072 1

310573 220873 151073 1

310574 220874 151074 1

310575 220875 151075 1

310576 220876 151076 1

310577 220877 151077 1

310578 220878 151078 1

310579 220879 151079 1

310580 220880 151080 1

310581 220881 151081 1

310582 220882 151082 1

310583 220883 151083 1

Application Schedule: 0.07 lb a.i./acre (adjusted); aerial spray, 95% effic. w/16% drift

***(early

- mid bloom, prior bunch closing, begin fruit ripening, +5 apps. prior to harvest)***

184 1 0 0

Zoxamide

140661 0 2 0.00 0.22 0.95 0.16

010861 0 2 0.00 0.22 0.95 0.16

220861 0 2 0.00 0.22 0.95 0.16

290861 0 2 0.00 0.22 0.95 0.16

050961 0 2 0.00 0.22 0.95 0.16

120961 0 2 0.00 0.22 0.95 0.16

190961 0 2 0.00 0.22 0.95 0.16

011061 0 2 0.00 0.22 0.95 0.16

140662 0 2 0.00 0.22 0.95 0.16

010862 0 2 0.00 0.22 0.95 0.16

220862 0 2 0.00 0.22 0.95 0.16

290862 0 2 0.00 0.22 0.95 0.16

050962 0 2 0.00 0.22 0.95 0.16

120962 0 2 0.00 0.22 0.95 0.16

190962 0 2 0.00 0.22 0.95 0.16

## 84 011062 0 2 0.00 0.22 0.95 0.16

140663 0 2 0.00 0.22 0.95 0.16

010863 0 2 0.00 0.22 0.95 0.16

220863 0 2 0.00 0.22 0.95 0.16

290863 0 2 0.00 0.22 0.95 0.16

050963 0 2 0.00 0.22 0.95 0.16

120963 0 2 0.00 0.22 0.95 0.16

190963 0 2 0.00 0.22 0.95 0.16

011063 0 2 0.00 0.22 0.95 0.16

140664 0 2 0.00 0.22 0.95 0.16

010864 0 2 0.00 0.22 0.95 0.16

220864 0 2 0.00 0.22 0.95 0.16

290864 0 2 0.00 0.22 0.95 0.16

050964 0 2 0.00 0.22 0.95 0.16

120964 0 2 0.00 0.22 0.95 0.16

190964 0 2 0.00 0.22 0.95 0.16

011064 0 2 0.00 0.22 0.95 0.16

140665 0 2 0.00 0.22 0.95 0.16

010865 0 2 0.00 0.22 0.95 0.16

220865 0 2 0.00 0.22 0.95 0.16

290865 0 2 0.00 0.22 0.95 0.16

050965 0 2 0.00 0.22 0.95 0.16

120965 0 2 0.00 0.22 0.95 0.16

190965 0 2 0.00 0.22 0.95 0.16

011065 0 2 0.00 0.22 0.95 0.16

140666 0 2 0.00 0.22 0.95 0.16

010866 0 2 0.00 0.22 0.95 0.16

220866 0 2 0.00 0.22 0.95 0.16

290866 0 2 0.00 0.22 0.95 0.16

050966 0 2 0.00 0.22 0.95 0.16

120966 0 2 0.00 0.22 0.95 0.16

190966 0 2 0.00 0.22 0.95 0.16

011066 0 2 0.00 0.22 0.95 0.16

140667 0 2 0.00 0.22 0.95 0.16

010867 0 2 0.00 0.22 0.95 0.16

220867 0 2 0.00 0.22 0.95 0.16

290867 0 2 0.00 0.22 0.95 0.16

050967 0 2 0.00 0.22 0.95 0.16

120967 0 2 0.00 0.22 0.95 0.16

190967 0 2 0.00 0.22 0.95 0.16

011067 0 2 0.00 0.22 0.95 0.16

140668 0 2 0.00 0.22 0.95 0.16

010868 0 2 0.00 0.22 0.95 0.16

220868 0 2 0.00 0.22 0.95 0.16

290868 0 2 0.00 0.22 0.95 0.16

050968 0 2 0.00 0.22 0.95 0.16

120968 0 2 0.00 0.22 0.95 0.16

190968 0 2 0.00 0.22 0.95 0.16

011068 0 2 0.00 0.22 0.95 0.16

140669 0 2 0.00 0.22 0.95 0.16

010869 0 2 0.00 0.22 0.95 0.16

220869 0 2 0.00 0.22 0.95 0.16

290869 0 2 0.00 0.22 0.95 0.16

050969 0 2 0.00 0.22 0.95 0.16

120969 0 2 0.00 0.22 0.95 0.16

190969 0 2 0.00 0.22 0.95 0.16

011069 0 2 0.00 0.22 0.95 0.16

140670 0 2 0.00 0 .22 0.95 0.16

010870 0 2 0.00 0.22 0.95 0.16

220870 0 2 0.00 0.22 0.95 0.16

290870 0 2 0.00 0.22 0.95 0.16

050970 0 2 0.00 0.22 0.95 0.16

120970 0 2 0.00 0.22 0.95 0.16

190970 0 2 0.00 0.22 0.95 0.16

011070 0 2 0.00 0.22 0.95 0.16

140671 0 2 0.00 0.22 0.95 0.16

010871 0 2 0.00 0.22 0.95 0.16

220871 0 2 0.00 0.22 0.95 0.16

## 85 290871 0 2 0.00 0.22 0.95 0.16

050971 0 2 0.00 0.22 0.95 0.16

120971 0 2 0.00 0.22 0.95 0.16

190971 0 2 0.00 0.22 0.95 0.16

011071 0 2 0.00 0.22 0.95 0.16

140672 0 2 0.00 0.22 0.95 0.16

010872 0 2 0.00 0.22 0.95 0.16

220872 0 2 0.00 0.22 0.95 0.16

290872 0 2 0.00 0.22 0.95 0.16

050972 0 2 0.00 0.22 0.95 0.16

120972 0 2 0.00 0.22 0.95 0.16

190972 0 2 0.00 0.22 0.95 0.16

011072 0 2 0.00 0.22 0.95 0.16

140673 0 2 0.00 0.22 0.95 0.16

010873 0 2 0.00 0.22 0.95 0.16

220873 0 2 0.00 0.22 0.95 0.16

290873 0 2 0.00 0.22 0.95 0.16

050973 0 2 0.00 0.22 0.95 0.16

120973 0 2 0.00 0.22 0.95 0.16

190973 0 2 0.00 0.22 0.95 0.16

011073 0 2 0.00 0.22 0.95 0.16

140674 0 2 0.00 0.22 0.95 0.16

010874 0 2 0.00 0.22 0.95 0.16

220874 0 2 0.00 0.22 0.95 0.16

290874 0 2 0.00 0.22 0.95 0.16

050974 0 2 0.00 0.22 0.95 0.16

120974 0 2 0.00 0.22 0.95 0.16

190974 0 2 0.00 0.22 0.95 0.16

011074 0 2 0.00 0.22 0.95 0.16

140675 0 2 0.00 0.22 0.95 0.16

010875 0 2 0.00 0.22 0.95 0.16

220875 0 2 0.00 0.22 0.95 0.16

290875 0 2 0.00 0.22 0.95 0.16

050975 0 2 0.00 0.22 0.95 0.16

120975 0 2 0.00 0.22 0.95 0.16

190975 0 2 0.00 0.22 0.95 0.16

011075 0 2 0.00 0.22 0.95 0.16

140676 0 2 0.00 0.22 0.95 0.16

010876 0 2 0.00 0.22 0.95 0.16

220876 0 2 0.00 0 .22 0.95 0.16

290876 0 2 0.00 0.22 0.95 0.16

050976 0 2 0.00 0.22 0.95 0.16

120976 0 2 0.00 0.22 0.95 0.16

190976 0 2 0.00 0.22 0.95 0.16

011076 0 2 0.00 0.22 0.95 0.16

140677 0 2 0.00 0.22 0.95 0.16

010877 0 2 0.00 0.22 0.95 0.16

220877 0 2 0.00 0.22 0.95 0.16

290877 0 2 0.00 0.22 0.95 0.16

050977 0 2 0.00 0.22 0.95 0.16

120977 0 2 0.00 0.22 0.95 0.16

190977 0 2 0.00 0.22 0.95 0.16

011077 0 2 0.00 0.22 0.95 0.16

140678 0 2 0.00 0.22 0.95 0.16

010878 0 2 0.00 0.22 0.95 0.16

220878 0 2 0.00 0.22 0.95 0.16

290878 0 2 0.00 0.22 0.95 0.16

050978 0 2 0.00 0.22 0.95 0.16

120978 0 2 0.00 0.22 0.95 0.16

190978 0 2 0.00 0.22 0.95 0.16

011078 0 2 0.00 0.22 0.95 0.16

140679 0 2 0.00 0.22 0.95 0.16

010879 0 2 0.00 0.22 0.95 0.16

220879 0 2 0.00 0.22 0.95 0.16

290879 0 2 0.00 0.22 0.95 0.16

050979 0 2 0.00 0.22 0.95 0.16

120979 0 2 0.00 0.22 0.95 0.16

190979 0 2 0.00 0 .22 0.95 0.16

## 86 011079 0 2 0.00 0.22 0.95 0.16

140680 0 2 0.00 0.22 0.95 0.16

010880 0 2 0.00 0.22 0.95 0.16

220880 0 2 0.00 0.22 0.95 0.16

290880 0 2 0.00 0.22 0.95 0.16

050980 0 2 0.00 0.22 0.95 0.16

120980 0 2 0.00 0.22 0.95 0.16

190980 0 2 0.00 0.22 0.95 0.16

011080 0 2 0.00 0.22 0.95 0.16

140681 0 2 0.00 0.22 0.95 0.16

010881 0 2 0.00 0.22 0.95 0.16

220881 0 2 0.00 0.22 0.95 0.16

290881 0 2 0.00 0.22 0.95 0.16

050981 0 2 0.00 0.22 0.95 0.16

120981 0 2 0.00 0.22 0.95 0.16

190981 0 2 0.00 0.22 0.95 0.16

011081 0 2 0.00 0.22 0.95 0.16

140682 0 2 0.00 0.22 0.95 0.16

010882 0 2 0.00 0.22 0.95 0.16

220882 0 2 0.00 0.22 0.95 0.16

290882 0 2 0.00 0 .22 0.95 0.16

050982 0 2 0.00 0.22 0.95 0.16

120982 0 2 0.00 0.22 0.95 0.16

190982 0 2 0.00 0.22 0.95 0.16

011082 0 2 0.00 0.22 0.95 0.16

140683 0 2 0.00 0.22 0.95 0.16

010883 0 2 0.00 0.22 0.95 0.16

220883 0 2 0.00 0.22 0.95 0.16

290883 0 2 0.00 0.22 0.95 0.16

050983 0 2 0.00 0.22 0.95 0.16

120983 0 2 0.00 0.22 0.95 0.16

190983 0 2 0.00 0.22 0.95 0.16

011083 0 2 0.00 0.22 0.95 0.16

0.0 3 0.0

0.00 0.00 0.50

Hornell Silt Loam; Hydrologic Group D;

100.00 0.0 0 0 1 0 0 0 0 0 0

0.0 0.0 0.0

4 64.16

3

1 18.00 1.400 0.322 0.000 0.000 0.00

.01100 .01100 0.000

0.1 0.322 0.162 1.740 0.0

2 66.00 1.500 0.310 0.000 0.000 0.00

.01100 .01100 0.000

1.0 0.310 0.200 0.174 0.0

3 16.00 1.950 0.260 0.000 0.000 0.00

.01100 .01100 0.0 00

1.0 0.260 0.190 0.116 0.0

0

YEAR 5 YEAR 5 YEAR 5 1

1

1

-----

6 DAY

PRCP TSER 0 0

RUNF TSER 0 0

ESLS TSER 0 0 1.0E3

RFLX TSER 0 0 1.0E5

EFLX TSER 0 0 1.0E5

RZFX TSER 0 0 1.0E5

1Exposure Analysis Modeling System

-- EXAMS Version 2.97, Mode 3

Chemical: 1) Benzoic Acid

----------------------------- ---------------------------------- Table 1.01.1 Chemical input data for neutral molecule (Sp.#1).

*** Chemical

- specific data: SET via "entry( 1)"

MWT: 2.05E+02 VAPR: 1.57E

- 04 HENRY: 1.52E

- 06 KOW:

## 87 KVO: EVPR: EHEN: KOC: 6.42E+01

*** Ion

- specific data: "entry(1, 1)"

SOL: 2.79E+02 KPB: KPS:

ESOL: KPDOC:

*** Reactivity of dissolved species: SET via "entry(1, 1, 1)"

KAH: EAH: KNH: ENH:

KBH: EBH: KRED: ERED:

KBACW: 3.40E

- 04 QTBAW: 2.00 KBACS: QTBAS: 2.00

*** Reactivity of solids

- sorbed species: "entry(2, 1, 1) "

KAH: EAH: KNH: ENH:

KBH: EBH: KRED: ERED:

KBACW: 3.40E

- 04 QTBAW: 2.00 KBACS: QTBAS: 2.00

*** Reactivity of "DOC"

- complexed species: "entry(3, 1, 1)"

KAH: EAH: KNH: ENH:

KBH: EBH: KRED: ERED:

KBACW: 3.40E

- 04 QTBAW: 2.00 KBACS: QTBAS: 2.00

*** Reactivity of bi osorbed species: "entry(4, 1, 1)"

KBACW: 3.40E

- 04 QTBAW: 2.00 KBACS: QTBAS: 2.00

**Zoxamide Residues PRZM and EXAMS New York grapes crop output for use in Index Reservoir/PCA**

**calculations.**

Zoxamide Residues. Grapes in New York. Index Res. Koc=64.2

WATER COLUMN DISSOLVED CONCENTRATION (PPB)

YEAR PEAK 96 HOUR 21 DAY 60 DAY 90 DAY YEARLY

---- ---- ------- ------ ------ ------ ------

196 1 30.630 29.700 27.230 24.890 22.180 7.279

1962 55.840 54.260 51.890 44.550 38.220 15.910

1963 19.370 18.960 17.320 14.070 11.990 8.468

1964 36.600 35.490 32.960 28.430 24.510 10.480

1965 29.950 29.050 25.790 21.470 20.280 9.864

1966 29.120 28.360 26.650 23.570 20.850 10.390

1967 53.830 52.320 47.240 40.890 35.640 14.500

1968 30.760 30.020 27.670 23.060 21.010 10.750

1969 30.690 29.770 27.150 23.000 20.780 9.018

1970 63.730 61.540 58.600 50.060 43.130 16.980

1971 47.110 45.700 40.810 35.000 31.34 0 14.100

1972 45.930 44.930 40.850 35.910 31.620 14.190

1973 27.600 26.770 23.730 20.630 18.120 8.864

1974 27.140 26.320 23.930 20.840 18.940 8.619

1975 43.460 41.850 38.400 37. 920 35.270 13.730

1976 42.230 40.960 37.400 32.560 29.710 12.590

1977 97.710 94.890 88.600 75.470 64.800 24.680

1978 55.530 54.080 49.720 42.250 36.710 17.980

1979 128.000 124.000 11 2.000 95.850 81.930 29.610

1980 75.860 73.890 67.290 56.980 52.470 25.380

1981 53.220 51.620 47.110 37.300 31.610 14.900

1982 30.330 29.290 27.540 25.570 22.860 11.600

1983 76.790 74.150 69.300 58.030 49.580 18.430

SORTED FOR PLOTTING

------ --- --------

PROB PEAK 96 HOUR 21 DAY 60 DAY 90 DAY YEARLY

---- ---- ------- ----- - ------ ------ ------

0.042 128.000 124.000 112.000 95.850 81.930 29.610

0.083 97.710 94.890 88.600 75.470 64.800 25.380

0.125 76.790 74.150 69.300 58.030 52.470 24.680

0.167 75.860 73.890 67.290 56.980 49.580 18.430

0.208 63.730 61.540 58.600 50.060 43.130 17.980

0.250 55.840 54.260 51.890 44.550 38.220 16.980

0.292 55.530 54.080 49.720 42.250 36.710 15.910

0.333 53.830 52.320 47.240 40.890 35.640 14.900

0.375 53.220 51.620 47.110 37.920 35.270 14.500

## 88 0.417 47.110 45.700 40.850 37.300 31.620 14.190

0.458 4 5.930 44.930 40.810 35.910 31.610 14.100

0.500 43.460 41.850 38.400 35.000 31.340 13.730

0.542 42.230 40.960 37.400 32.560 29.710 12.590

0.583 36.600 35.490 32.960 28.430 24.5 10 11.600

0.625 30.760 30.020 27.670 25.570 22.860 10.750

0.667 30.690 29.770 27.540 24.890 22.180 10.480

0.708 30.630 29.700 27.230 23.570 21.010 10.390

0.750 30.330 29.290 27.150 23.060 20.850 9.864

0.792 29.950 29.050 26.650 23.000 20.780 9.018

0.833 29.120 28.360 25.790 21.470 20.280 8.864

0.875 27.600 26.770 23.930 20.840 18.940 8.619

0.917 27.140 26.320 23.730 20.630 18.120 8.468

0.958 19.370 18.960 17.320 14.070 11.990 7.279

1/10 89.342 86.594 80.880 68.494 59.868 25.100

MEAN OF ANNUAL VALUES = 14.274

STANDARD DEVIATION OF ANNUAL VALUES = 5.844

UPPER 90% CONFIDENCE LIMIT ON MEAN = 16.094

**Zoxamide Residues PRZM and EXAMS Maine potato crop input for use in index reservoir/PCA calculations**

*** PRZM 3.1 Input Data File coverted from PRZM 2.3; S.ABEL ***

*** IRMeTotl.INP created October 26, 2000 ***

*** ***

*** Total Parent Plus Degradates Run

*** ***

*** Modeler: M. Corbin ***

*** Index Reservoir and PCA Scenario for DW Assessment***

*** Assume 4% slope, conventional tillage with crop residue left ***

*** on the field after harvest ***

*** Manning's N value for planted across slope poor stand at ***

*** 20% maturity (for small grains) ***

*** Application by aerial spray ***

*** PCA for potatoes not available, use default PCA of 0. 87 ***

Zoxamide

Conant Silt Loam MLRA M

- 143, Arastook County, ME

0.770 0.150 0 12.50 1 3

4

0.28 0.44 1.00 172.80 5.80 3 4.00 600.00

1

1 0.10 30.00 90.00 3 91 85 88 0.00 60.0

1 3

0101 0105 0109

0.43 0.27 0.43

.018 .018 .018

36

050548 080948 180948 1

050549 080949 180949 1

050550 080950 180950 1

050551 080951 180951 1

050552 080952 180952 1

050553 080953 180953 1

050554 080954 180954 1

050555 080955 180955 1

050556 080956 180956 1

050557 080957 180957 1

050558 0 80958 180958 1

050559 080959 180959 1

050560 080960 180960 1

050561 080961 180961 1

050562 080962 180962 1

050563 080963 180963 1

## 89 050564 080964 180964 1

050565 080965 180965 1

050566 080966 180966 1

050567 080967 180967 1

050568 080968 180968 1

050569 080969 180969 1

050570 080970 180970 1

050571 080971 180971 1

050572 080972 180972 1

050573 080973 180973 1

050574 080974 180974 1

050575 080975 180975 1

050576 080976 180976 1

050577 080977 180977 1

050578 080978 180978 1

050579 080979 180979 1

050580 080980 180980 1

050581 080981 180981 1

050582 080982 180982 1

050583 080983 180983 1

Application Schedule: Aerial @ 0.22 kgs a.i/ha (adjusted), 8 times @ 5 day intervals,

288 1 0 0

Zoxamide:

060548 0 2 0.0 0.22 0.95 0.16

110548 0 2 0.0 0.22 0.95 0.16

160548 0 2 0.0 0.22 0.95 0.16

210548 0 2 0.0 0.22 0.95 0.16

260548 0 2 0.0 0.22 0.95 0.16

310548 0 2 0.0 0.22 0.95 0.16

050648 0 2 0.0 0.22 0.95 0.16

110648 0 2 0.0 0.22 0.95 0.16

060549 0 2 0.0 0.22 0.95 0.16

110549 0 2 0.0 0.22 0.95 0.16

160549 0 2 0.0 0.22 0.95 0.16

210549 0 2 0.0 0.22 0.95 0.16

260549 0 2 0.0 0.22 0.95 0.16

310549 0 2 0.0 0.22 0.95 0.16

050649 0 2 0.0 0.22 0.95 0.16

110649 0 2 0.0 0.22 0.95 0.16

060550 0 2 0.0 0.22 0.95 0.16

110550 0 2 0.0 0.22 0.95 0.16

160550 0 2 0.0 0.22 0.95 0.16

210550 0 2 0.0 0.22 0.95 0.16

260550 0 2 0.0 0.22 0.95 0.16

310550 0 2 0.0 0. 22 0.95 0.16

050650 0 2 0.0 0.22 0.95 0.16

110650 0 2 0.0 0.22 0.95 0.16

060551 0 2 0.0 0.22 0.95 0.16

110551 0 2 0.0 0.22 0.95 0.16

160551 0 2 0.0 0.22 0.95 0.16

210551 0 2 0.0 0.22 0.95 0.16

260551 0 2 0.0 0.22 0.95 0.1 6

310551 0 2 0.0 0.22 0.95 0.16

050651 0 2 0.0 0.22 0.95 0.16

110651 0 2 0.0 0.22 0.95 0.16

060552 0 2 0.0 0.22 0.95 0.16

110552 0 2 0.0 0.22 0.95 0.16

160552 0 2 0.0 0.22 0.95 0.16

210552 0 2 0.0 0.22 0.95 0.16

260552 0 2 0.0 0.22 0.95 0.16

310552 0 2 0.0 0.22 0.95 0.16

050652 0 2 0.0 0.22 0.95 0.16

110652 0 2 0.0 0.22 0.95 0.16

060553 0 2 0.0 0.22 0.95 0.16

110553 0 2 0.0 0.22 0.95 0.16

160553 0 2 0.0 0.22 0.95 0.16

210553 0 2 0.0 0.22 0.95 0.16

260553 0 2 0.0 0.22 0.95 0.16

## 90 310553 0 2 0.0 0.22 0.95 0.16

050653 0 2 0.0 0.22 0.95 0.16

110653 0 2 0.0 0.22 0.95 0.16

060554 0 2 0.0 0.22 0.95 0.16

110554 0 2 0.0 0.22 0.95 0.16

160554 0 2 0.0 0.22 0.95 0.16

210554 0 2 0.0 0.22 0.95 0.16

260554 0 2 0.0 0.22 0.95 0.16

310554 0 2 0.0 0.22 0.95 0.16

050654 0 2 0.0 0.22 0.95 0.16

110654 0 2 0.0 0.22 0.95 0.16

060555 0 2 0.0 0.22 0.95 0.16

110555 0 2 0.0 0.22 0.95 0.16

160555 0 2 0.0 0.22 0.95 0.16

210555 0 2 0.0 0.22 0.95 0.16

260555 0 2 0.0 0.22 0.95 0.16

310555 0 2 0.0 0.22 0.95 0.16

050655 0 2 0.0 0.22 0.95 0.16

110655 0 2 0.0 0.22 0.95 0.16

060556 0 2 0.0 0.22 0.95 0.16

110556 0 2 0.0 0.22 0.95 0.16

160556 0 2 0.0 0.22 0.95 0.16

210556 0 2 0.0 0.22 0.95 0.16

260556 0 2 0.0 0.22 0.95 0.16

310556 0 2 0.0 0.22 0.95 0.16

050656 0 2 0.0 0.22 0.95 0.16

110656 0 2 0.0 0 .22 0.95 0.16

060557 0 2 0.0 0.22 0.95 0.16

110557 0 2 0.0 0.22 0.95 0.16

160557 0 2 0.0 0.22 0.95 0.16

210557 0 2 0.0 0.22 0.95 0.16

260557 0 2 0.0 0.22 0.95 0.16

310557 0 2 0.0 0.22 0.95 0.16

050657 0 2 0.0 0.22 0.95 0. 16

110657 0 2 0.0 0.22 0.95 0.16

060558 0 2 0.0 0.22 0.95 0.16

110558 0 2 0.0 0.22 0.95 0.16

160558 0 2 0.0 0.22 0.95 0.16

210558 0 2 0.0 0.22 0.95 0.16

260558 0 2 0.0 0.22 0.95 0.16

310558 0 2 0.0 0.22 0.95 0.16

050658 0 2 0.0 0.22 0.95 0.16

110658 0 2 0.0 0.22 0.95 0.16

060559 0 2 0.0 0.22 0.95 0.16

110559 0 2 0.0 0.22 0.95 0.16

160559 0 2 0.0 0.22 0.95 0.16

210559 0 2 0.0 0.22 0.95 0.16

260559 0 2 0.0 0.22 0.95 0.16

310559 0 2 0.0 0.22 0.95 0.16

050659 0 2 0.0 0.22 0.95 0.16

110659 0 2 0.0 0.22 0.95 0.16

060560 0 2 0.0 0.22 0.95 0.16

110560 0 2 0.0 0.22 0.95 0.16

160560 0 2 0.0 0.22 0.95 0.16

210560 0 2 0.0 0.22 0.95 0.16

260560 0 2 0.0 0. 22 0.95 0.16

310560 0 2 0.0 0.22 0.95 0.16

050660 0 2 0.0 0.22 0.95 0.16

110660 0 2 0.0 0.22 0.95 0.16

060561 0 2 0.0 0.22 0.95 0.16

110561 0 2 0.0 0.22 0.95 0.16

160561 0 2 0.0 0.22 0.95 0.16

210561 0 2 0.0 0.22 0.95 0 .16

260561 0 2 0.0 0.22 0.95 0.16

310561 0 2 0.0 0.22 0.95 0.16

050661 0 2 0.0 0.22 0.95 0.16

110661 0 2 0.0 0.22 0.95 0.16

060562 0 2 0.0 0.22 0.95 0.16

## 91 110562 0 2 0.0 0.22 0.95 0.16

160562 0 2 0.0 0.22 0.95 0.16

210562 0 2 0.0 0.22 0.95 0.16

260562 0 2 0.0 0.22 0.95 0.16

310562 0 2 0.0 0.22 0.95 0.16

050662 0 2 0.0 0.22 0.95 0.16

110662 0 2 0.0 0.22 0.95 0.16

060563 0 2 0.0 0.22 0.95 0.16

110563 0 2 0.0 0.22 0.95 0.16

160563 0 2 0.0 0.22 0.95 0.16

210563 0 2 0.0 0.22 0.95 0.16

260563 0 2 0.0 0.22 0.95 0.16

310563 0 2 0.0 0.22 0.95 0.16

050663 0 2 0.0 0.22 0.95 0.16

110663 0 2 0.0 0.22 0.95 0.16

060564 0 2 0.0 0. 22 0.95 0.16

110564 0 2 0.0 0.22 0.95 0.16

160564 0 2 0.0 0.22 0.95 0.16

210564 0 2 0.0 0.22 0.95 0.16

260564 0 2 0.0 0.22 0.95 0.16

310564 0 2 0.0 0.22 0.95 0.16

050664 0 2 0.0 0.22 0.95 0.16

110664 0 2 0.0 0.22 0.95 0.16

060565 0 2 0.0 0.22 0.95 0.16

110565 0 2 0.0 0.22 0.95 0.16

160565 0 2 0.0 0.22 0.95 0.16

210565 0 2 0.0 0.22 0.95 0.16

260565 0 2 0.0 0.22 0.95 0.16

310565 0 2 0.0 0.22 0.95 0.16

050665 0 2 0.0 0.22 0.95 0.16

110665 0 2 0.0 0.22 0.95 0.16

060566 0 2 0.0 0.22 0.95 0.16

110566 0 2 0.0 0.22 0.95 0.16

160566 0 2 0.0 0.22 0.95 0.16

210566 0 2 0.0 0.22 0.95 0.16

260566 0 2 0.0 0.22 0.95 0.16

310566 0 2 0.0 0. 22 0.95 0.16

050666 0 2 0.0 0.22 0.95 0.16

110666 0 2 0.0 0.22 0.95 0.16

060567 0 2 0.0 0.22 0.95 0.16

110567 0 2 0.0 0.22 0.95 0.16

160567 0 2 0.0 0.22 0.95 0.16

210567 0 2 0.0 0.22 0.95 0.16

260567 0 2 0.0 0.22 0.95 0.1 6

310567 0 2 0.0 0.22 0.95 0.16

050667 0 2 0.0 0.22 0.95 0.16

110667 0 2 0.0 0.22 0.95 0.16

060568 0 2 0.0 0.22 0.95 0.16

110568 0 2 0.0 0.22 0.95 0.16

160568 0 2 0.0 0.22 0.95 0.16

210568 0 2 0.0 0.22 0.95 0.16

260568 0 2 0.0 0.22 0.95 0.16

310568 0 2 0.0 0.22 0.95 0.16

050668 0 2 0.0 0.22 0.95 0.16

110668 0 2 0.0 0.22 0.95 0.16

060569 0 2 0.0 0.22 0.95 0.16

110569 0 2 0.0 0.22 0.95 0.16

160569 0 2 0.0 0.22 0.95 0.16

210569 0 2 0.0 0.22 0.95 0.16

260569 0 2 0.0 0.22 0.95 0.16

310569 0 2 0.0 0.22 0.95 0.16

050669 0 2 0.0 0.22 0.95 0.16

110669 0 2 0.0 0.22 0.95 0.16

060570 0 2 0.0 0.22 0.95 0.16

110570 0 2 0.0 0.22 0.95 0.16

160570 0 2 0.0 0 .22 0.95 0.16

210570 0 2 0.0 0.22 0.95 0.16

260570 0 2 0.0 0.22 0.95 0.16

## 92 310570 0 2 0.0 0.22 0.95 0.16

050670 0 2 0.0 0.22 0.95 0.16

110670 0 2 0.0 0.22 0.95 0.16

060571 0 2 0.0 0.22 0.95 0.16

110571 0 2 0.0 0.22 0.95 0.16

160571 0 2 0.0 0.22 0.95 0.16

210571 0 2 0.0 0.22 0.95 0.16

260571 0 2 0.0 0.22 0.95 0.16

310571 0 2 0.0 0.22 0.95 0.16

050671 0 2 0.0 0.22 0.95 0.16

110671 0 2 0.0 0.22 0.95 0.16

060572 0 2 0.0 0.22 0.95 0.16

110572 0 2 0.0 0.22 0.95 0.16

160572 0 2 0.0 0.22 0.95 0.16

210572 0 2 0.0 0.22 0.95 0.16

260572 0 2 0.0 0.22 0.95 0.16

310572 0 2 0.0 0.22 0.95 0.16

050672 0 2 0.0 0.22 0.95 0.16

110672 0 2 0.0 0.22 0.95 0.16

060573 0 2 0.0 0.22 0.95 0.16

110573 0 2 0.0 0.22 0.95 0.16

160573 0 2 0.0 0.22 0.95 0.16

210573 0 2 0.0 0.22 0.95 0.16

260573 0 2 0.0 0.22 0.95 0.16

310573 0 2 0.0 0.22 0.95 0.16

050673 0 2 0.0 0.22 0.95 0 .16

110673 0 2 0.0 0.22 0.95 0.16

060574 0 2 0.0 0.22 0.95 0.16

110574 0 2 0.0 0.22 0.95 0.16

160574 0 2 0.0 0.22 0.95 0.16

210574 0 2 0.0 0.22 0.95 0.16

260574 0 2 0.0 0.22 0.95 0.16

310574 0 2 0.0 0.22 0.95 0.16

050674 0 2 0.0 0.22 0.95 0.16

110674 0 2 0.0 0.22 0.95 0.16

060575 0 2 0.0 0.22 0.95 0.16

110575 0 2 0.0 0.22 0.95 0.16

160575 0 2 0.0 0.22 0.95 0.16

210575 0 2 0.0 0.22 0.95 0.16

260575 0 2 0.0 0.22 0.95 0.16

310575 0 2 0.0 0.22 0.95 0.16

050675 0 2 0.0 0.22 0.95 0.16

110675 0 2 0.0 0.22 0.95 0.16

060576 0 2 0.0 0.22 0.95 0.16

110576 0 2 0.0 0.22 0.95 0.16

160576 0 2 0.0 0.22 0.95 0.16

210576 0 2 0.0 0.22 0.95 0.16

260576 0 2 0.0 0. 22 0.95 0.16

310576 0 2 0.0 0.22 0.95 0.16

050676 0 2 0.0 0.22 0.95 0.16

110676 0 2 0.0 0.22 0.95 0.16

060577 0 2 0.0 0.22 0.95 0.16

110577 0 2 0.0 0.22 0.95 0.16

160577 0 2 0.0 0.22 0.95 0.16

210577 0 2 0.0 0.22 0.95 0. 16

260577 0 2 0.0 0.22 0.95 0.16

310577 0 2 0.0 0.22 0.95 0.16

050677 0 2 0.0 0.22 0.95 0.16

110677 0 2 0.0 0.22 0.95 0.16

060578 0 2 0.0 0.22 0.95 0.16

110578 0 2 0.0 0.22 0.95 0.16

160578 0 2 0.0 0.22 0.95 0.16

210578 0 2 0.0 0.22 0.95 0.16

260578 0 2 0.0 0.22 0.95 0.16

310578 0 2 0.0 0.22 0.95 0.16

050678 0 2 0.0 0.22 0.95 0.16

110678 0 2 0.0 0.22 0.95 0.16

060579 0 2 0.0 0.22 0.95 0.16

## 93 110579 0 2 0.0 0.22 0.95 0.16

160579 0 2 0.0 0.22 0.95 0.16

210579 0 2 0.0 0.22 0.95 0.16

260579 0 2 0.0 0.22 0.95 0.16

310579 0 2 0.0 0.22 0.95 0.16

050679 0 2 0.0 0.22 0.95 0.16

110679 0 2 0.0 0.22 0.95 0.16

060580 0 2 0.0 0.22 0.95 0.16

110580 0 2 0.0 0.22 0.95 0.16

160580 0 2 0.0 0.22 0.95 0.16

210580 0 2 0.0 0.22 0.95 0.16

260580 0 2 0.0 0.22 0.95 0.16

310580 0 2 0.0 0.22 0.95 0.16

050680 0 2 0.0 0.22 0.95 0.16

110680 0 2 0.0 0.22 0.95 0.16

060581 0 2 0.0 0.22 0.95 0.16

110581 0 2 0.0 0.22 0.95 0.16

160581 0 2 0.0 0.22 0.95 0.16

210581 0 2 0.0 0.22 0.95 0.16

260581 0 2 0.0 0.22 0.95 0.16

310581 0 2 0.0 0.22 0.95 0.16

050681 0 2 0.0 0.22 0.95 0.16

110681 0 2 0.0 0.22 0.95 0.16

060582 0 2 0.0 0.22 0.95 0.16

110582 0 2 0.0 0.22 0.95 0.16

160582 0 2 0.0 0.22 0.95 0.16

210582 0 2 0.0 0.22 0.95 0.16

260582 0 2 0.0 0.22 0.95 0.16

310582 0 2 0.0 0.22 0.95 0.16

050682 0 2 0.0 0. 22 0.95 0.16

110682 0 2 0.0 0.22 0.95 0.16

060583 0 2 0.0 0.22 0.95 0.16

110583 0 2 0.0 0.22 0.95 0.16

160583 0 2 0.0 0.22 0.95 0.16

210583 0 2 0.0 0.22 0.95 0.16

260583 0 2 0.0 0.22 0.95 0.16

310583 0 2 0.0 0.22 0.95 0.1 6

050683 0 2 0.0 0.22 0.95 0.16

110683 0 2 0.0 0.22 0.95 0.16

0.0 3

0.0 0.0 0.5

Soil Series: Conant Silt Loam

100.00 0 0 1 0 0 0 0 0 0

0.0 0.00 0.00

4 64.16

4

1 10.00 1.250 0.341 0.000 0.000 0.000

.0110 .01100 0.000

0.1 0.341 0.121 4.640 0.0

2 16.00 1.250 0.341 0.000 0.000 0.000

.01100 .01100 0.000

1.0 0.341 0.121 4.640 0.0

3 64.00 1.400 0.266 0.000 0.000 0.000

.01100 .01100 0.000

1.0 0.266 0.116 0.174 0.0

4 10.00 1.600 0.261 0.000 0.000 0.000

.01100 .01100 0 .000

1.0 0.261 0.111 0.116 0.0

0

WATR YEAR 10 PEST YEAR 10 CONC YEAR 10 1

1

1

-----

6 DAY

PRCP TSER 0 0

RUNF TSER 0 0

ESLS TSER 0 0 1.0E3

RFLX TSER 0 0 1.0E5

EFLX TSER 0 0 1.0E5

## 94 RZFX TSER 0 0 1.0E5

1Exposure Analysis Modeling System

-- EXAMS Version 2.97, Mode 3

Chemical: 1) Benzoic Acid

---------------------------- ----------------------------------- Table 1.01.1 Chemical input data for neutral molecule (Sp.#1).

*** Chemical

- specific data: SET via "entry( 1)"

MWT: 2.05E+02 VAPR: 1.57E

- 04 HENRY: 1.52E

- 06 KOW:

KVO: EVPR: EHEN: KOC: 6.42E+01

*** Ion

- specific data: "entry(1, 1)"

SOL: 2.79E+02 KPB: KPS:

ESOL: KPDOC:

*** Reactivity of dissolved species: SET via "entry(1, 1, 1)"

KAH: EAH: KNH: ENH:

KBH: EBH: KRED: ERED:

KBACW: 3.40E

- 04 QTBAW: 2.00 KBACS: QTBAS: 2.00

*** Reactivity of solids

- sorbed species: "entr y(2, 1, 1)"

KAH: EAH: KNH: ENH:

KBH: EBH: KRED: ERED:

KBACW: 3.40E

- 04 QTBAW: 2.00 KBACS: QTBAS: 2.00

*** Reactivity of "DOC"

- complexed species: "entry(3, 1, 1)"

KAH: EAH: KNH: ENH:

KBH: EBH: KRED: ERED:

KBACW: 3.40E

- 04 QTBAW: 2.00 KBACS: QTBAS: 2.00

*** Reactivity of bi osorbed species: "entry(4, 1, 1)"

KBACW: 3.40E

- 04 QTBAW: 2.00 KBACS: QTBAS: 2.00

**Zoxamide Residues PRZM and EXAMS Maine potato crop output for use in Index Reservoir/PCA calculations.**

Zoxamide Residues. Potatoes in Maine. Index Res. Koc=64.2

WATER COLUMN DISSOLVED CONCENTRATION (PPB)

YEAR PEAK 96 HOUR 21 DAY 60 DAY 90 DAY YEARLY

---- ---- ------- ------ ------ ------ ------

1948 10.660 10.390 9.687 8. 832 8.095 3.392

1949 8.852 8.627 7.996 7.315 7.038 3.461

1950 9.804 9.555 8.897 7.606 6.820 3.144

1951 8.750 8.528 8.106 7.650 6.946 3.078

1952 20.060 19.550 1 8.880 15.580 13.360 5.344

1953 12.930 12.600 11.220 9.982 9.581 4.659

1954 14.230 13.870 12.990 10.710 9.384 4.132

1955 38.130 37.160 34.960 28.650 24.990 9.527

1956 25.250 24.610 23.470 19.920 17.200 7.397

1957 22.370 22.040 20.050 16.010 14.350 6.656

1958 13.700 13.350 12.780 10.850 9.462 4.365

1959 15.890 15.490 13.910 11.010 9.65 0 4.136

1960 20.990 20.460 19.300 15.760 14.160 6.068

1961 11.680 11.360 10.730 9.939 8.879 4.247

1962 12.430 12.120 11.050 9.571 8.687 3.963

1963 9.099 8.869 8.230 7. 317 6.724 3.190

1964 12.750 12.430 11.830 10.820 9.712 4.147

1965 21.030 20.590 19.300 15.430 13.110 5.481

1966 11.380 11.090 10.250 8.604 7.604 3.594

1967 10.500 10.330 9.569 8.214 7.368 3.257

1968 9.596 9.353 8.851 8.035 7.183 3.114

1969 18.870 18.400 16.570 13.630 12.200 4.922

1970 13.230 12.870 11.910 10.460 9.596 4.363

1971 9.443 9.204 8.785 7.886 7.142 3.297

1972 30.490 29.720 26.740 21.030 17.800 7.090

1973 23.470 22.880 21.410 19.170 17.030 7.356

1974 21.520 20.970 18.740 15.020 13.520 6.114

1975 9.238 9.004 8.363 7.542 7.016 3.575

## 95 1976 19.200 18.720 17.660 16.540 14.910 6.087

1977 9.123 8.892 8.254 7.105 6.440 3.156

1978 11.610 11.320 10.650 9.022 7.924 3 .349

1979 12.240 11.930 10.940 9.430 8.171 3.425

1980 10.750 10.470 9.846 7.983 7.879 4.000

1981 15.050 14.670 13.720 11.960 10.710 4.632

1982 20.950 20.420 18.490 16.570 14.690 6.142

1983 19.420 19.010 18.520 15.690 13.610 5.767

SORTED FOR PLOTTING

------ --- --------

PROB PEAK 96 HOUR 21 DAY 60 DAY 90 DAY YEARLY

---- ---- ------- ------ ------ ------ ------

0.027 38.130 37.160 34.960 28.650 24.990 9.527

0.054 30.490 29.720 26.740 21.030 17.800 7 .397

0.081 25.250 24.610 23.470 19.920 17.200 7.356

0.108 23.470 22.880 21.410 19.170 17.030 7.090

0.135 22.370 22.040 20.050 16.570 14.910 6.656

0.162 21.520 20.970 19.3 00 16.540 14.690 6.142

0.189 21.030 20.590 19.300 16.010 14.350 6.114

0.216 20.990 20.460 18.880 15.760 14.160 6.087

0.243 20.950 20.420 18.740 15.690 13.610 6.068

0.270 20.060 19.550 18.520 15.580 13.520 5.767

0.297 19.420 19.010 18.490 15.430 13.360 5.481

0.324 19.200 18.720 17.660 15.020 13.110 5.344

0.351 18.870 18.400 16.570 13.630 12.200 4.922

0.378 15.890 15.490 13.910 11.960 10.710 4.659

0.405 15.050 14.670 13.720 11.010 9.712 4.632

0.432 14.230 13.870 12.990 10.850 9.650 4.365

0.459 13.700 13.350 12.780 10.820 9.596 4.363

0.486 13.230 12.870 11.910 10.710 9.581 4.247

0.514 12.930 12.600 11.830 10.460 9.462 4.147

0.541 12.750 12.430 11.220 9.982 9.384 4.136

0.568 12.430 12.120 11.050 9.939 8.879 4.132

0.595 12.240 11.930 10.940 9.571 8.687 4.000

0.622 11.680 11.360 10.730 9.430 8.171 3.963

0.649 1 1.610 11.320 10.650 9.022 8.095 3.594

0.676 11.380 11.090 10.250 8.832 7.924 3.575

0.703 10.750 10.470 9.846 8.604 7.879 3.461

0.730 10.660 10.390 9.687 8.214 7.6 04 3.425

0.757 10.500 10.330 9.569 8.035 7.368 3.392

0.784 9.804 9.555 8.897 7.983 7.183 3.349

0.811 9.596 9.353 8.851 7.886 7.142 3.297

0.838 9.443 9.204 8.785 7.650 7.038 3.257

0.865 9.238 9.004 8.363 7.606 7.016 3.190

0.892 9.123 8.892 8.254 7.542 6.946 3.156

0.919 9.099 8.869 8.230 7.317 6.820 3.144

0.946 8.852 8.627 8.106 7.315 6.724 3.114

0.973 8.750 8.528 7.996 7.105 6.440 3.078

1/10 24.004 23.399 22.028 19.395 17.081 7.170

MEAN OF ANNUAL VALUES = 4.712

STANDARD DEVIATION OF ANNUAL VALUES = 1.560

UPPER 90% CONFIDENCE LIMIT ON MEAN = 5.097

**Zoxamide SCIGROW input/output for ground water concentration.**

RUN No. 1 FOR Parent Zoxamide INPUT VALUES

------------------------------- -------------------------------------

APPL (#/AC) APPL. URATE SOIL SOIL AEROBIC

## 96 RATE NO. (#/AC/YR) KOC METABOLISM (DAYS)

--------------------------------------------------------------------

.200 8 1.600 1294.0 37.8

GROUND

- WATER SCREENING CONCENTRATIONS IN PPB

--------------------------------------------------------

.060639

--------------------------------------------------------

A= 32.800 B= 1299.000 C= 1 .516 D= 3.114 RILP= 1.344

F=

- 1.421 G= .038 URATE= 1.600 GWSC= .060639

**Zoxamide Residues SCIGROW input/output for ground water concentration.**

RUN No. 1 FOR Zoxamide + Degradates

- INPUT VALUES

---------------- ----------------------------------------------------

APPL (#/AC) APPL. URATE SOIL SOIL AEROBIC

RATE NO. (#/AC/YR) KOC METABOLISM (DAYS)

--------------------------------------------------------------------

.22 0 8 1.760 64.2 61.8

GROUND

- WATER SCREENING CONCENTRATIONS IN PPB

--------------------------------------------------------

2.069801

--------------------------------------------------------

A= 56.800 B= 69.200 C= 1.754 D= 1.840 RILP= 3.789

F= .070 G= 1.176 URATE= 1.760 GWSC= 2.069801

## 97 APPENDIX C

TOXICITY DATA TABLES

## 98 ECOLOGICAL HAZARD SUMMARY :

Hazard Summary :

Toxicity to Freshwater Aquatic Animals

Freshwater Fish, Acute

Zoxamide in its simplest formulation is categorized as highly toxic to freshwater fishes on an

acute basis while as a co

- formulated product mancozeb it is categorized as moderately toxic to

freshwater fishes. The guideline (72

- 1) is fulfilled. The results of this test are tabulated below:

Table C1

- Freshwater Fish Acute Toxicity Test :

Species/Flow

Through %ai LC 50 

### Value

(ppb) Toxicity

Category MRID No./

Author/Year Study

Classification

Rainbow trout

( Oncorhynchus

mykiss)

Rainbow trout

( Oncorhynchus

mykiss) 94.2

69%mancozeb

+ 8.26%

zoxamide 156

1900 Highly toxic

Moderately 447319

- 26

/Sword/1995

449505

- 03/

Rhodes/1998 Core

Core

Bluegill sunfish

(Lepomis

macrochirus) 94.2 >790 Highly toxic 447319

- 27/

Sword/

1995 Core



## Freshwater Fish, Chronic

Zoxamide is categorized as a reproductive inhibitor for freshwater fishes on a chronic basis. The

guideline (72

- 4) is fulfilled. The results of this test are tabulated below:

Table C 2

--- Freshwater Fish Early Life

- Stage Toxicity Under Flow

- through Conditions

NOAEC /

## 99 Species/ %ai LOAEC

(ppb) Endpoints

Affected MRID/

Author/

Year Study

Classification

Rainbow trout

( Oncorhynchus

mykiss) 92.9% 3.48/

6.87 Post hatch

survival rate

affected.

Resulted show

10% below the

normal rate 447319

- 29/

Downing/1996 Core



## Freshwater Fish Life

- Cycle Toxicity Test :

Zoxamide is categorized as a reproductive inhibitor to freshwater fishes on a chronic using the

Fish Life

- Cycle Toxicity Test The preferred test organism is the fathead minnow. The guideline

(72

- 5) is fulfilled. The results of t his test are tabulated below

Table C3

- Freshwater Fish Life

- Cycle Toxicity Test

Species %ai NOAEC/

LOAEC

(ppb) Toxicity

Endpoints MRID/

Author/ Year Study

Classification

Fathead

minnow

( Pimephales

promelas ) 92.3% 60/

121 Affected

parameters

length, hatch

success, 28 D

survival 447319

- 31/

Drottar/

1998 Core



## Freshwater Invertebrates, Acute

Technical grade zoxamide is categorized as very highly toxic to freshwater invertebrates and

when co

- formulated with mancozeb it is categorized as moderately toxic to freshwater

invertebrates on an acute level. The guideline (72

- 2) is fulfilled. The pr eferred test species is

Daphnia magna . Results of this test are tabulated below

Table C4

-- Freshwater Invertebrate Acute Toxicity Test

Species %ai EC 50 

### (ppb) Toxicity

Category MRID/Author/

Year Study

Classification

## 100 Daphnid

( Daphnia

magna )

Daphnid

( Daphnia

magna ) 94.2%

69% mancozeb

+ 8.26

Zoxamide > 780

3800 No More than

Highly toxic

Moderately

toxic 447319

- 20/

Sword/ 1995

449505

- 02/

Madsen/1998 Core

Core



## Freshwater Invertebrate, Chronic

Zoxamide is categorized as survival rate and reproductive inhibitor to freshwater invertebrates on

a chronic basis. The guideline (72

- 4) is fulfilled. The data for this information is presented

below

Table C5

- Freshwater Invertebrate Chronic Reproduction Toxicity Te st

Species %ai NOAEC/

LOAEC

(ppb) Toxicity

Endpoints

Affected MRID/Author/

Year Study

Classification

Daphnid

( Daphnia

magna )

Midge

( Chironomus

riparius ) 92.3%

92.3% 39/74

210/340 Survival Rate

Affected

Survival rate

Affected 447319

- 21/

Murrell/

1997

447319

- 22/

Kolk/1998 Core

Supplemental



## Toxicity to Estuarine and Marine Animals

Estuarine and Marine Fish, Acute

Zoxamide is categorized as practically non

- toxic to estuarine/marine fishes on an acute basis as

the high does nears the solubility limit. The preferred test species is sheepshead minnow. The

guideline (72

- 3) is fulfilled. Results of these tests are tabulated below.

Table C6

- Estuarine/marine fish Acute Toxicity Test

Species %ai EC 50 

### Value

(ppb) Toxicity

Category MRID/

Author/ Year Study

Classification

## 101 Sheepshead

minnow

( Cyprinodon

variegatus ) 92.3% >860 Practically

non

- toxic 447319

- 28/

Roberts/

1997 Core



## Estuarine and Marine Fish, Chronic

The results of this test show zoxamide is categorized as a growth inhbitor to estuarine/marine

fishes on a chronic basis. The preferred test species is sheepshead minnow. The guideline

(72

- 4a) is fulfilled. Results of this test are tabula ted below:

Table C7

- Estuarine/marine Fish Chronic Toxicity Test

Species %ai NOAEC/

LOAEC

(ppb) Toxicity

Endpoints

Affected MRID/

Author/ Year Study

Classification

Sheepshead

minnow

( Cyprinodon

variegatus ) 92.3% 40/78 Length affected

at

250 ppb 447319

- 30/

Drottar &

Krueger/

1998 Core



## Estuarine and Marine Invertebrates, Acute

The results of this test indicate zoxamide is very highly toxic to estuarine/marine shrimp and

highly toxic to the Eastern oyster on an acute basis. The preferred test species are mysid shrimp

and eastern oyster. The guideline (72

- 3b and 72

- 3c) is fulfilled. Results of these tests are

tabulated below.

Table C8

- Estuarine/marine Invertebrate Acute Toxicity Test

Species/

Flow

- through % ai. 96

- hour

LC 50 

### (ppb)

(measured) Toxicity

Category MRID No.

Author/Year Study

Classification

Eastern Oyster 447319

- 24/

## 102 ( Crassostrea

virginica ) 92.3% 715 Highly

Toxic Roberts/

1997 Core

Saltwater Mysid

( Mysidopsis

bahia ) 92.3% 75 Very Highly

Toxic 447319

- 23/

Roberts

1997 Core



## Estuarine and Marine Invertebrate, Chronic

The results indicate zoxamide is reproductive inhibitor to estuarine/marine invertebrates on a

chronic basis as growth and reproduction rates are affected in this study. The preferred test

species is mysid shrimp. The guideline (72

- 4b) is fulfilled. Results of this test are tabulated

below:

Table C9

- Estuarine/marine Invertebrate Chronic Toxicity Test

Species % ai NOAEC/

LOAEC

(ppb) Toxicity

Endpoints

Affected MRID No.

Author/ Year Study

Classification

Saltwater Mysid

( Mysidopsis

bahia 92.3% 7.2/14 Reproduction

and

growth affected.

Results 10%

below the

normal

measurements 447319

- 25

Drottar/1998 Core



## Insects

An analysis of the results show zoxamide is practically non

- toxic to honey bees on an acute

contact and acute oral basis. The guideline (141

- 1) is fulfilled (256454). The results of these test

are tabulated below:

Table C10

- acute Oral & Contact Toxicity Test

Species/(Static

Renewal) % ai LD 50



### (ug/bee) Toxicity

Category MRID No.

Author/Year Study

Classification

## 103 Honeybee

( Apis mellifera )

Honey bee

( Apis

mellifera ) > 95%

69% mancozeb

&

8.3% Zoxamide >153 ug ai/bee

>200 ug ai/bee Practically

non

- toxic

Relatively

Non

- toxic 447319

- 19/

Kirkland/1993

449505

- 04/

Engelhard/1997 Core

Core



## Toxicity to Terrestrial Animals

Mammals, Acute and Chronic

Wild mammal testing is required on a case

- by

- case basis, depending on the results of lower tier

laboratory mammalian studies, intended use pattern and pertinent environmental fate

characteristics. In most cases, rat or mouse toxicity va lues obtained from the Agency's Health

Effects Division (HED) substitute for wild mammal testing. An analysis of the results indicate

that zoxamide is categorized as practically non

- toxic to mammals on an acute oral basis and

the potential for chronic reproductive effects appears to be low when using the highest does tested.

The guidelines are fulfilled. These toxicity values are reported below.

Table C11

- Mammalian Acute Oral Toxicity

Species %ai Test Type Toxicity

Values MRID No. Study

Classification

Laboratory Rat

( Rattus

norvegicus ) 97.7% (Purity) Acute Oral LD 50 

### = >5,000

mg/kg 44731837 Core

Laboratory

mouse 97.7% (Purity) Acute Oral LD50 = >5,000

mg/kg 44731834 Core



## Table C12

- Mammalian Reproductive Toxicity

Species % ai Test Type Toxicity

Values MRID No. Study

Classification

2

- Generation

## 104 reproduction

laboratory rat

(Rattus

norvegicus 92.3% Chronic

Reproductive NOAEL=

20,000 ppm 44770001 Core



## Birds, Oral Acute and Subacute

On an oral acute basis zoxamide is categorized as practically non

- toxic to avian species. The

guideline (71

- 1) is fulfilled. Results of this test are tabulated below:

Table C13

-- Avian Acute Oral Toxicity

Species %ai LD 50 

### mg/kg Toxicity

Category MRID/Author/

Yr Study

Classification

Bobwhite quail

( Colinus

virginianus ) 92.9% >2000 mg/kg Practically

non

- toxic 447319

- 33/Will

iams/1997 Core



## On an oral subacute basis, the LC 50 

## value for both species tested was greater than 5250 ppm.

Zoxamide practically non

- toxic for avian organisms on a subacute basis. The guideline (71

- 2) is

fulfilled. The results of this test are tabulated below:

Table C14

- Avian Subacute Dietary Toxic ity

Species %ai LC 50 

### (ppm) Toxicity

category MRID/Author/

Yr Study

Classification

Bobwhite quail

( Colinus

virginianus 92.9% >5250 Practically

non

- toxic 447319

- 34/

Williams/1997 Core

Mallard duck

( Anas

platyrhnchos ) 92.9% >5250 Practically

non

- toxic 447319

- 35/

Williams/1997 Core



## Birds, Chronic

The data submitted indicate that zoxamide exposures of 1000 ppm to bobwhite quail and mallard

duck will not result in reproductive effects. Therefore, the guideline (71

- 4) is fulfilled.

Results of these tests are tabulated below:

Table C15

- Avian Reproduction

## 105 Species %ai NOAEC/

LOAEC

(ppm) Toxicity

Endpoint

Affected MRID/Author/

Yr Study

Classification

Bobwhite quail

( Colinus

virginianus

Mallard duck

( Anas

platyrhnchos ) 92.3%

92.3% 1000/>1000

1000/>1000 None

None 447319

- 36/Kap

ustka/1998

449474

- 01/

Gallagher/1999 Core

Core



## Toxicity to Plants

Of the five semi

- aquatic plants tested, the most sensitive were the Lemna gibba and green algae as

indicated in the OECD and FIFRA studies. The guideline (123

- 2

- Tier II) is fulfilled. The data is

tabulated below.

Table C16

- Semi

- Aquatic Plant Acute and Chronic Toxicity

Species %ai EC 50 

### Value

(ppb) NOAEC

(ppb) MRID/Author/

Yr Study

Classification

S. capricorntum 92.9% 23 4.1 447319

- 38/Zieg

ler/

1996 Core

Navicula

## 106 pelliculosa

(freshwater

diatom) 92.3% >930 210 447700

- 05/

Drottar/1998 Core

Skeletonema

costatum

(Marine diatom) 92.3% >910 490 447319

- 42/

Drottar/1998 Core

Lemna gibba

(Duckweed)

Lemna gibba

(Duckweed) 92.3%

96.3% 19

19 9.0

9.0 447319

- 45/

Drottar/1998

447319

- 45/

Drottar/1998 Core

Core

Anabaena

flos

- aquae (Freshwater Alga)

Scenedesmus

subspicatus

(freshwater alga)

Scenedesmus

subspicatus

(freshwater alga) 92.3%

92.3%

96.3% >860

10

10 860

7.0

7.0 447319

- 40/

Drottar/1998

447319

- 39/

Drottar/1998

447319

- 39/

Drottar/1998 Core

Supplemental 1

Supplemental 1

1. The algae tested is not a recommended test species

## 107 APPENDIX D

GENERALIZED EFED RISK ASSESSMENT METHOD AND CALCULATION TABLES

FOR RISK QUOTIENTS

## 108 The risk assessment integrates the results of the exposure and ecotoxicity data to evaluate the likelihood of adverse

ecological effects. The means of this integration is called the quotient method. Risk quotients (RQs) are calculated

by dividing acute a nd chronic exposure estimates by toxicity values.

RQ = EXPOSURE/TOXICITY

RQs are then compared to OPP's levels of concern (LOCs). These LOCs are used by OPP to assess potential risk to

nontarget organisms and the need to consider regulatory action. The criteria indicate that a pesticide used as directed

has the potential to cause adverse effects on nontarget organisms. LOCs currently address the following risk

presumption categories: (1) acute high

-- potential for acute risk is high; regulatory action may be warranted in

addition to restricted use classification, (2) acute restricted use

-- the potential for acute risk is high, but may be

mitigated through restricted use classification, (3) acute endangered species

- endangered species may be adversely

affected if actual exposure occurs, and (4) chronic risk

- the potential for chronic risk is high, regulatory action may be

warranted. Currently, EFED does not perform assessments for chronic risk to plants, acute or chronic risk s to

nontarget insects, or chronic risk from granular/bait formulations to birds or mammals.

The ecotoxicity test values (measurement endpoints) used in the acute and chronic risk quotients are derived from

required studies. Examples of ecotoxicity value s derived from short

- term laboratory studies that assess acute effects

are: (1) LC50 (fish and birds), (2) LD50 (birds and mammals), (3) EC50 (aquatic plants and aquatic invertebrates) and

(4) EC25 (terrestrial plants). Examples of toxicity test effect le vels derived from the results of long

- term laboratory

studies that assess chronic exposure

- related effects are: (1) LOAEC (birds, fish, and aquatic invertebrates) and (2)

NOAEC (birds, fish and aquatic invertebrates). For birds and mammals, the NOAEC gene rally is used as the

ecotoxicity test value in assessing chronic exposure risks, although other values may be used when justified.

Generally, the NOAEC is used as the ecotoxicity test value in assessing chronic exposure risks to fish and aquatic

invertebr ates.

Risk presumptions and the corresponding RQs and LOCs, are tabulated on the following page.



## Risk Presumptions for Terrestrial Animals

Risk Presumption RQ LOC

Birds

Acute High Risk EEC 1 

## /LC50 or LD50/sqft 2 

## or LD50/day 3 

## 0.5

Acute Restricted Use EEC/LC50 or LD50/sqft or LD50/day (or

LD50 < 50 mg/kg) 0.2

Acute Endangered Species EEC/LC50 or LD50/sqft or LD50/day 0.1

## 109 Risk Presumptions for Terrestrial Animals

Risk Presumption RQ LOC

Chronic Risk EEC/NOEC 1

1 

## abbreviation for Estimated Environmental Concentration (ppm) on avian/mammalian food

items

2 

## mg/ft 2 3



## Risk Presumptions for Aquatic Animals mg of toxicant consumed/day

LD50 * wt. of bird LD50 * wt. of bird

Risk Presumption RQ LOC

Acute High Risk EEC 1 

## /LC50 or EC50 0.5

Acute Restricted Use EEC/LC50 or EC50 0.1

Acute Endangered Species EEC/LC50 or EC50 0.05

Chronic Risk EEC/MATC or NOEC 1

1 

## EEC = (ppm or ppb) in water

## 110 Table D1

- Risk quotients for Freshwater fishes using the Rainbow Trout And

PRZM/EXAM Modeling

Site LC 50 (ppb) NOAEC

(ppb) PRZM/EXAM

Initial

(ppb) PRZM/EXAM

60 day

(ppb) Acute

Risk

quotient Chronic

Risk

Quotient

Grapes

(0.2 lbs ai/A, 8

applications, 7

day intervals)

Potatoes

(0.2 lbs ai/A, 8

applications, 5

day intervals) 156 ppb

(Rainbow

trout

Onchorynchus

mykiss)

156 ppb

(Rainbow

trout

Onchorynchus

mykiss) 3.48

Rainbow

trout

( Onchorynchu

s mykiss)

3.48

Rainbow

trout

( Onchorynchu

s mykiss) 7.5

2.3 1.1

0.4 0.05

0.015 0.32

0.11



## Table D2

- Freshwater Fish Early Life

- Stage Toxicity Under Flow

- through

Conditions

Site NOAEC

(ppb) PRZM/EXAMS

60

- Day Chronic

Risk

Quotient

Grapes,

(0.2 lbs ai/A, 8 applications, 7

day intervals)

Potatoes

(0.2 lbs ai/A, 8 applications, 5

day intervals) 3.48

3.48 1.1

0.4 0.32

0.11



## Table D3

-- Risk Quotients For Early Life

- Stage Freshwater Fish Using The Fathead

minnow

Site NOAEC

(ppb) PRZM/EXAMS

60

- Day

(ppb) Chronic

Risk

Quotient

Grapes,

(0.2 lbs ai/A, 8 applications, 7

day intervals)

Potatoes

(0.2 lbs ai/A, 8 applications, 5

day intervals) 60

60 1.1

0.4 0.018

0.007

## 111 Table D4

- Risk Quotients For Freshwater Invertebrates Using the **Daphnia magna**

And PRZM/EXAMS Modeling.

Site EC 50 (ppb) NOAEC

(ppb) PRZM/EXAMS

Initial

(pbb) PRZM/EXAM

21

- day

(ppb) Acute

Risk

Quotient Chronic

Risk

Quotient

Grapes,

(0.2 lbs ai/A, 8

applications, 7

day intervals) > 780

Daphnid

Daphnia

magna ) 39

Daphnid

Daphnia

magna ) 7.5 2.1 <0.01 0.05

Potatoes

(0.2 lbs ai/A, 8

applications, 5

day intervals) 3800

Daphnid

Daphnia

magna ) 39

Daphnid

Daphnia

magna ) 2.3 0.6 0.0006 0.015



## Table D5

-- Risk Quotients For Estuarine/marine fishes using the sheepshead

minnow and PRZM/EXAMS Modeling

Site EC 50 NOAEC

(ppb) PRZM/EXAM

Initial

(ppb) PRZM/EXAM

60

- day

(ppb) Acute

Risk

Quotient Chronic

Risk

Quotient

Grapes,

(0.2 lbs ai/A, 8

applications, 7

day intervals)

Potatoes

(0.2 lbs ai/A, 8

applications, 5

day intervals) >860

Sheepshead

minnow

( Cyprinodon

variegatus )

>860

Sheepshead

minnow

( Cyprinodon

variegatus ) 40

Sheepshead

minnow

( Cyprinodon

variegatus )

40

Sheepshead

minnow

( Cyprinodon

variegatus 7.5

2.3 1.1

0.4 <0.009

<0.003 0.03

0.01



## Table D6

-- Risk Quotients for Estuarine/marine invertebrates using the mysid

shrimp and PRZM/EXAMS Modeling

Site EC 50 (ppb) NOAEC

(ppb) PRZM/EXAM

Initial

(ppb) PRZM/EXAM

21

- Day

(ppb) Acute

Risk

Quotient Chronic

Risk

quotient

Grapes,

(0.2 lbs ai/A, 8

applications, 7

day intervals)

Potatoes

(0.2 lbs ai/A, 8

applications, 5

day intervals) 75

75 7.2

7.2 7.5

2.3 2.1

0.6 0.1

0.03 0.29

0.08

## 112 Table D7

-- Multiple Applications of Zoxamide for Avian Species

Site Food Items Maximum

EECs

(ppm)

Chronic Maximum

EECs

(ppm **)**

For acute LC 50 (ppm) NOAEC

ppm Acute RQ

(EEC/LC 50 Chronic RQ

(EEC/NOAEC)

Grapes/

Aerial/

0.2 lbs ai/A 8

times per yr Short Grass

Tall Grass

Broadleaf

plants/insects

Seeds 248.48

113.89

139.77

15.53 248.48

113.89

139.77

15.53 >5250 1000 <0.05

<0.02

<0.03

< 0.01 0.25

0.11

0.14

0.015

Potatoes/

Aerial/

0.2 lbs ai/ Short Grass

Tall Grass

Broadleaf

plants/insects

Seeds 278.57

127.68

156.70

17.41 278.57

127.68

156.70

17.41 >5250 1000 <0.05

<0.02

<0.03

<0.01 0.30

0.13

0.16

0.02



## Table D8

-- Mammalian (Herbivore/Insectivore) Acute Risk Quotients For Multiple

Applications Of Non

- granular Products(Broadcast) Based on Rattus norvegicus

LD 50 

## of >5,000 mg/kg

Site/App.

Method/

App Rate/

No. Of App Body

weight

(grams) % Body

weight

Consume

d Rat

LD 50 (mg/kg) EEC

(ppm)

Short

Grass EEC

(ppm)

Forage &

Small

Insects EEC

(ppm)

Large

Insects Acute

RQ

Short

Grass Acute

RQ

Forage

Small

Insects Acute

RQ

Large

Insects

Grapes/

Aerial/

0.2 lbs ai/A 8

times per yr 15

35

1000 95

66

15 >5,000

> 5,000

>5,000 248.48

248.48

248.48 113.89

113.89

113.89 139.77

139.77

139.77 <0.05

<0.03

<0.01 <0.02

<0.02

<0.01 <0.03

<0.02

<0.01

Potatoes/

Aerial/

0.2 lbs ai/ 15

35

1000 95

66

15 >5,000

>5,000

>5,000 278.57

278.57

278.57 127.68

127.68

127.68 156.70

156.70

156.70 <0.05

<0.04

<0.01 <0.02

<0.02

<0.01 <0.03

<0.02

<0.01

1

Mammalian RQ’s = EEC

LD 50 / (%Body weight Of Mammals)

## 113 Table D9

-- Mammalian (Granivore) Acute Risk Quotients for Multiple Applications of

Non

- granular Products (Broadcast) based on Rattus norvegicus LD 50 

## of >5,000 mg/kg

Site Body Weight

(g) %Body Weight

Consumed Rat LD 50 (mg/kg) EEC

(ppm)

Seeds Acute RQ 1 Seed

Grapes/Aerial/

0.2 lbs ai/A 8 times

per yr

15

35

1000 21

15

3 >5000

>5,000

>5,000 15.53

15.53

15.53 <0.01

<0.01

<0.01

Potatoes/

Aerial/

0.2 lbs ai/ 15

35

1000 21

15

3 >5000

> 5,000

>5,000 17.41

17.41

17.41 <0.01

<0.01

<0.01

1 

## Mammalian RQ= EEC

LD 50 

## /(%Body Weight)

Table

- D10

- Mammalian (Granivore) Chronic Risk Quotients For Multiple

Applications of Non

- granular products (Broadcast) based on Rattus norvegicus

NOAEL of 20,000 ppm

Site/

Application

rate/

Number of

application Rat NOAEL

Toxicity

(ppm)

Value EEC

(ppm)

Short Grass EEC

(ppm)

Forage &

Small

Insects EEC

(ppm)

Large

Insects Chronic

Risk

Quotient

Short Grass Chronic

Risk

Quotients

(Forage &

Small

Insects) Chronic

Risk

Quotients

(Large

Insects)

Grapes/

Aerial/

0.2 lbs ai/A 8

times per yr 20,000 248.48 113.89 139.77 0.01 0.006 0.007

Potatoes/

Aerial/

0.2 lbs ai/ 20,000 278.57 127.68 156.70 0.01 0.006 0.008

## 114 Table

- D11

-- Risk Quotients For Terrestrial and Semi

- aquatic plants

Species Application Site EC 50 (ppb) PRZM/EXAMS

(ppb) Acute

Value

Navicula pelliculosa

(freshwater diatom) Grapes

(0.2 lbs ai/A, 8

applications, 7 day

intervals)

Potatoes

(0.2 lbs ai/A, 8

applications, 5 day

intervals) >930

>930 7.5

2.3 <0.08

<0.02

Lemna gibba

(Duckweed) Grapes

(0.2 lbs ai/A, 8

applications, 7 day

intervals)

Potatoes

(0.2 lbs ai/A, 8

applications, 5 day

intervals) 19

19 7.5

2.3 0.40

0.12

## 115 APPENDIX E

DATA REQUIREMENTS

## 116 Table D

- 1. Environmental Fate Data Requirements For Zoxamide

Guideli

ne # Data Requirement Is Data

Requirement

Satisfied? MRID #’s Study

Classification



### 161

- 1 Hydrolysis yes 44731908 acceptable

161

- 2 Photodegradation in Water yes 44731911 acceptable

161

- 3 Photodegradation on Soil yes 44731910 acceptable

161

- 4 Photodegradation in Air Not required

162

- 1 Aerobic Soil Metabolism yes

no 44731912

44731913 acceptable

162

- 2 Anaerobic Soil Metabolism yes 44731914 acceptable

162

- 3 Anaerobic Aquatic Metabolism Not

submitted

162

- 4 Aerobic Aquatic Metabolism yes 44770002 acceptable

163

- 1 Leaching/Adsorption/Desorption no 44731916 partially

163

- 2 Laboratory Volatility

163

- 3 Field Volatility not required

164

- 1 Terrestrial Field Dissipation no

no 44732126

44732127 supplemental

164

- 2 Aquatic Field Dissipation not required supplemental

164

- 3 Forestry Dissipation not required

165

- 4 Accumulation in Fish yes acceptable

165

- 5 Accumulation

- aquatic non

- target not required

166

- 1 Ground Water

- small prospective not required

166

- 2 Ground Water

- small

retrospective not required

201

- 1 Droplet Size Spectrum reserved

202

- 1 Drift Field Evaluation reserved

## 117 Table D

- 2. Ecological Effects Data Requirements for Zoxamide



### Guidelin

e # Data Requirement MRID # Classification Is data requirement satisfied?

71

- 1 Avian acute oral LD 50 

### Bobwhite quail

Mallard Duck 447319

- 33 Core

Core Yes

71

- 2 Avian subacute dietary LC 50 

### bobwhite quail

mallard duck 447319

- 44

447319

- 35 Core

Core Yes

71

- 4 Avian reproduction

bobwhite quail

mallard duck 447319

- 36

447319

- 37 Core

Core Yes

72

- 1 Freshwater fish acute LC 50 

### /EC 50



### rainbow trout

bluegill sunfish 447319

- 26

447319

- 27 Core

Core Yes

72

- 2 Freshwater invertebrate acute

LC 50 

### (daphnia) 447319

- 20 Core Yes

72

- 3a Estuarine/marine fish acute LC 50 

### (sheepshead minnow) 447319

- 28 Core Yes

72

- 3b Estuarine/marine acute

invertebrateEC 50 

### (mysid) 447319

- 23 Core Yes

72

- 3c Estuarine/marine acute

invertebrate EC 50 

### (mollusc) 447319

- 24 Core Yes

72

- 4a Freshwater fish early life stage

(rainbow trout) 447319

- 29 Supplemental Yes

72

- 4c Estuarine/marine fish early life

stage

(sheepshead minnow) 447319

- 30 Supplemental Yes

72

- 4b Freshwater invertebrate life cycle

(daphnia) 447319

- 21 Core Yes

72

- 4d Estuarine/marine life cycle

(mysid) 447319

- 25 Core Yes

72

- 5 Freshwater fish full life cycle

(fathead minnow) 447319

- 31 Core Yes

81

- 1 Acute mammalian oral LD 50 

### (rat) 44731837

44731834 Core Yes

83

- 1 Mammalian Chronic (rat) 44770001 Core Yes

123

- 2 Aquatic plant acute EC 50 

### 447319

- 38

---- -----

144

- 1 Acute honeybee oral LC 50 

### 447319

- 19 Core Yes

144

- 2 Acute honeybee contact 4490505

- 04 Core Yes

70

- 1 earthworm toxicity 44770003 Supplemental Yes

## 118 APPENDIX F

REFERENCES

## 119 REFERENCES

Jones, R.D., S.W. Abel, W. Effland, R. Matzner, and R. Parker. 1998. “An Index Reservoir for Use in Assessing Drinking Water

Exposures. Chapter IV in Proposed Methods for Basin

- Scale Estimation of Pesticide Concentrations in Flowing Water and

Reservoirs f or Tolerance Reassessment. , presented to the FIFRA Science Advisory Panel, Junly 29,

1998. http://www.epa.gov/pesticides/SAP/1998/index.htm

Water Quality Technical Team/Environmental Fate and Effects Division/OPP. August 6,. 2000. Guidance for Chemistry and

Management Practice Input Parameters For Use in Modeling the Environmental Fate and Transport of Pesticides: GENEEC,

PRZM/EXAMS/SCI

- GROW.