SCREENING-LEVEL HAZARD CHARACTERIZATION AND 

PRIORITIZATION DOCUMENT 

BUTENEDIOIC ACID DIALKYL ESTERS CLUSTER 

14 Chemicals 

MPV Chemical(s)

CAS Registry Number CA1 Index Name

141-02-6 2-Butenedioic acid (2E)-, 1,4-bis(2-ethylhexyl) ester 

141-05-9 2-Butenedioic acid (2Z)-, 1,4-diethyl ester 

2915-52-8 2-Butenedioic acid (2Z)-, 1,4-didodecyl ester 

14234-82-3 2-Butenedioic acid (2Z)-, 1,4-bis(2-methylpropyl) ester 

53817-54-2 2-Butenedioic acid (2Z)-, 1,4-diisononyl ester 

61791-92-2 2-Butenedioic acid (2Z)-, 1,4-ditridecyl ester 

624-48-6 2-Butenedioic acid (2Z)-, 1,4-dimethyl ester 

HPV Chemical(s)

CAS Registry Number CA Index Name

621-13-6 2-Butenedioic acid (2Z)-, 1,4-dicyclohexyl ester 

68610-90-2 2-Butenedioic acid (2E)-, di-C8-18-alkyl esters 

68921-51-7 2-Butenedioic acid (2E)-, di-C12-18-alkyl esters 

Supporting Chemical(s)

CAS Registry Number CA Index Name

105-52-2 2-Butenedioic acid (2Z)-, 1,4-bis(1,3-dimethylbutyl) ester 

105-76-0 2-Butenedioic acid (2Z)-, 1,4-dibutyl ester 

142-16-5 2-Butenedioic acid (2Z)-, 1,4-bis(2-ethylhexyl) ester 

623-91-6 2-Butenedioic acid (2E)-, 1,4-diethyl ester 

 

1

 Chemical Abstracts 
U.S. Environmental Protection Agency March 2009 

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Prepared by

Office of Pollution Prevention and Toxics 

Environmental Protection Agency 

1200 Pennsylvania Avenue, NW 

Washington, DC 20460-0001 
U.S. Environmental Protection Agency March 2009 

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SCREENING-LEVEL HAZARD CHARACTERIZATION AND 

PRIORITIZATION DOCUMENT 

Screening-level hazard characterizations for medium production volume chemicals are 

important contributions to the chemicals cooperation work being done in North America2

through the EPA Chemical Assessment and Management Program (ChAMP)3

. This 

chemical cluster was organized to maximize the potential information available to inform 

screening-level prioritization of chemicals needing further consideration and, where 

possible, to prioritize among multiple needs. Although most of the information 

considered relates to hazard, inferences about exposure that can be drawn from existing 

environmental fate and regulatory information have also been used, and information from 

the 2006 Inventory Update Reporting (IUR)4 is included to inform exposure potential 

when it is available. 

These screening-level hazard characterizations are technical documents intended to 

support subsequent decisions and actions by Office of Pollution Prevention and Toxics 

(OPPT). They provide a vehicle for public access to a concise assessment of the 

technical data on MPV chemicals and provide information previously not readily 

available to the public. The screening-level hazard characterizations, as the name 

indicates, do not evaluate the potential risks of a chemical or cluster of chemicals. This 

initial prioritization does not constitute a final Agency determination. Recommended 

actions may be considered by EPA in the future based on a relative judgment regarding 

one or more of the chemicals in comparison with others evaluated under this program, 

and in light of the uncertainties presented by gaps in the available data that may be 

determined to exist. 

The purpose of organizing chemicals into structural clusters for this characterization was 

to maximize the number of potential analogs identified for the MPV chemicals, thus 

maximizing the potential data available to inform the MPV hazard characterizations. 

Organizing each chemical and associated data within a cluster will help assessors identify 

chemical trends, detect outlying estimates and measured data, facilitate read across, assist 

in weight of evidence approaches, and support identification of appropriate sub 

clustering. During the review of each cluster, assessors will likely determine endpoint 

specific subclasses depicting sets of compounds with potentially similar mechanistic or 

biological properties within the larger structural cluster. These endpoint specific sub 

clusters, breakpoints, and trends will be described within each section of the hazard 

characterization. 

 

2

 USEPA, U.S. Commitments to North American Chemicals Cooperation: 

http://www.epa.gov/hpv/pubs/general/sppframework.htm. 3

 USEPA, ChAMP information: http://www.epa.gov/champ/. 4

 USEPA, IUR Reporting information: http://www.epa.gov/oppt/iur/index.htm. 
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1. STRUCTURAL CLUSTER JUSTIFICATIONS 

The butenedioic acid dialkyl esters cluster consists of fourteen symmetrical alkyl and alkenyl 

esters of maleic and fumaric acid ((Z)- and (E)- butenedioic acid). The alkyl groups range from 

C1-C18 and may be linear, branched or cyclic. Two of the cluster members are mixtures of 

varying chain lengths. For these mixtures, the lowest molecular weight member was used for 

structural representation on the data tables. However, for sections of the hazard assessment 

where models were used to estimate endpoints, the representative structures used as input to the 

models or as the basis for read across vary depending on the hazard assessed. Therefore, refer to 

the text of each hazard section for information on specific assessment methods applied. 

The following chemicals are listed on the 2006 IUR reporting as either HPVs or MPVs and are 

subject to this prioritization assessment. 

MPV Chemical(s)

CAS Registry Number CA Index Name

141-02-6 2-Butenedioic acid (2E)-, 1,4-bis(2-ethylhexyl) ester 

141-05-9 2-Butenedioic acid (2Z)-, 1,4-diethyl ester 

2915-52-8 2-Butenedioic acid (2Z)-, 1,4-didodecyl ester 

14234-82-3 2-Butenedioic acid (2Z)-, 1,4-bis(2-methylpropyl) ester 

53817-54-2 2-Butenedioic acid (2Z)-, 1,4-diisononyl ester 

61791-92-2 2-Butenedioic acid (2Z)-, 1,4-ditridecyl ester 

624-48-6 2-Butenedioic acid (2Z)-, 1,4-dimethyl ester 

HPV Chemical(s)

CAS Registry Number CA Index Name

621-13-6 2-Butenedioic acid (2Z)-, 1,4-dicyclohexyl ester 

68610-90-2 2-Butenedioic acid (2E)-, di-C8-18-alkyl esters 

68921-51-7 2-Butenedioic acid (2E)-, di-C12-18-alkyl esters 

The following other chemicals provided in this cluster are used as supporting chemicals to help 

inform the hazard characterization and prioritization decisions. 2-Butenedioic acid (2Z)-, 1,4-

bis(1,3-dimethylbutyl) (105-52-2), 2-butenedioic acid (2Z)-, 1,4-dibutyl ester (105-76-0), and 2-

butenedioic acid (2Z)-, 1,4-bis(2-ethylhexyl) ester (142-16-5) have been assessed previously by 

EPA as part of the Diesters Category Risk-Based Prioritization. 2-Butenedioic acid (2E)-, 1,4-
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diethyl ester (623-91-6) has been assessed previously in the Organisation for Economic 

Cooperation and Development’s (OECD) HPV Programme. 

CAS Registry Number CA Index Name

105-52-2 2-Butenedioic acid (2Z)-, 1,4-bis(1,3-dimethylbutyl) 

ester 

105-76-0 2-Butenedioic acid (2Z)-, 1,4-dibutyl ester 

142-16-5 2-Butenedioic acid (2Z)-, 1,4-bis(2-ethylhexyl) ester 

623-91-6 2-Butenedioic acid (2E)-, 1,4-diethyl ester 

2. PHYSICAL-CHEMICAL PROPERTIES (Table A) 

Experimental physical-chemical properties data are available for the majority of members in this 

cluster. Where measured data were not available, the physical-chemical property values were 

estimated using EPISuite v4.00. For physical-chemical property estimations on the non-discrete 

mixtures in this cluster, the smallest molecular weight member was used as structural input to the 

model, or was used as the basis for read-across. The members of this cluster are expected to be 

liquids under standard temperature and pressure conditions with the exception of four members 

which are solids. The log of the octanol/water partition coefficients range from 0.8 to greater 

than 15 and the boiling point values range from 168 to >540 degrees Celsius. Vapor pressure is 

negligible to high and water solubility is negligible to high. All endpoints generally trend as 

expected with increasing carbon chain length and degree of branching. 

3. ENVIRONMENTAL FATE (Table A) 

Limited experimental environmental fate data were available for the members of the butenedioic 

acid dialkyl esters cluster. Where measured data were not available, the environmental fate 

properties for members of this cluster were estimated using EPI SuiteTM v4.00. For the mixtures 

in this cluster, the environmental fate estimates were completed using the smallest molecular 

weight member of the mixture. The members of this cluster are expected to have high to low 

mobility in soil. Volatilization from water and wet soil for the butenedioic acid dialkyl esters is 

considered moderate based on Henry’s Law constants. The rate of atmospheric photooxidation 

for members of this cluster is considered slow to moderate. The rate of hydrolysis is considered 

slow to negligible. Some of the members in this cluster undergo photolysis. The rate of aerobic 

biodegradation is expected to be rapid to moderate. Fugacity models indicate that the cluster 

members partition predominately to water and soil. The BAF values are less than the BCF values 

for the butenedioic acid dialkyl esters cluster because the BCFBAFTM v3.00 program accounts 

for metabolic biotransformation when calculating BAF values, which mitigates the 

bioaccumulation potential compared to BCF values. Butenedioic acid dialkyl esters are expected 

to have low overall persistence and low bioaccumulation potential. 

4. AQUATIC ORGANISM TOXICITY (Table B) 
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OPPT previously used read across from 2-butenedioic acid (2Z)-, 1,4-dibutyl ester (105-76-0) to 

characterize aquatic toxicity endpoints for: 2-butenedioic acid (2Z)-, 1,4-bis(1,3-dimethylbutyl) 

ester (105-52-2) and 2-Butenedioic acid (2Z)-, 1,4-bis(2-ethylhexyl) ester (142-16-5) (U.S. EPA, 

2008). This same read-across is applied to cluster member, 2-butenedioic acid (2E)-, 1,4-bis(2-

ethylhexyl) ester (141-02-8), which is an optical isomer of 2-butenedioic acid (2Z)-, 1,4-bis(2-

ethylhexyl) ester (142-16-5). It is noted that the chemicals for which read across was applied 

have higher log Kow values than 105-76-0, and therefore may present slightly higher toxicity. 

Where measured data were not available, the aquatic toxicity values for the members of this 

cluster were estimated using the neutral organics class in ECOSAR v1.00. For the 2 members of 

this cluster which are mixtures comprised of a range of homologs with varying alkyl chains the 

largest molecular weight member (reflecting the highest log Kow value) was used as input to the 

model. This approach is expected to provide a ‘worst case’ estimate because for neutral organics, 

aquatic toxicity increases with increasing log Kow up the point where solubility is so low (and log 

Kow correspondingly high) as to limit toxicity and no effects at saturation are expected. 

Available experimental and estimated data for fish, daphnia and green algae indicate acute 

toxicity ranges from high to low in a predictable trend related to log Kow and water solubility. 

Acute toxicity for 2-butenedioic acid (2Z)-, dimethyl ester (624-48-6) is estimated to be low. 

The remaining eight members of this cluster with log Kows ranging between 2 and 8 are expected 

to have moderate to high acute toxicity that increases with increasing carbon number and log 

Kow. Cluster members with log Kow above 8 (68610-90-2, 53817-54-2, 2915-52-8, 61791-92-2, 

and 68921-51-7) are estimated to show no effects at saturation due to their limited water 

solubility. 

With the exception of two invertebrate studies, all chronic toxicity data were estimated and 

follow the same expected trend related to log Kow and water solubility as acute toxicity. Chronic 

toxicity for 2-butenedioic acid (2Z)-, dimethyl ester (624-48-6) is estimated to be low and 

chronic toxicity of the remaining eight cluster members with log Kows ranging between 2 and 8 

are estimated to have moderate to high chronic toxicity that increases with increasing carbon 

number and log Kow. Low chronic hazard (no effects at saturation) for 68610-90-2, 53817-54-2, 

2915-52-8, 61791-92-2, and 68921-51-7 are expected due to their limited water solubility. 

5. HUMAN HEALTH TOXICITY (Table C) 

OPPT previously used read across from 2-butenedioic acid (2Z)-, 1,4-dibutyl ester (105-76-0) to 

characterize acute, repeated-dose, developmental, reproductive, genotoxicity and skin 

sensitization endpoints for: 2-butenedioic acid (2Z)-, 1,4-bis(1,3-dimethylbutyl) ester (105-52-2) 

and 2-butenedioic acid (2Z)-, 1,4-bis(2-ethylhexyl) ester (142-16-5) (U.S. EPA, 2008). This 

same read-across is applied to cluster member, 2-butenedioic acid (2E)-, 1,4-bis(2-ethylhexyl) 

ester (141-02-8), which is an optical isomer of 2-butenedioic acid (2Z)-, 1,4-bis(2-ethylhexyl) 

ester (142-16-5). 

Seven cluster members have been tested for acute toxicity. Acute toxicity of the butenedioic 

acid dialkyl esters cluster is generally low via the oral route of exposure in rats. Acute toxicity of 

the lower molecular weight cluster member, 2-butenedioic acid (2Z)-, dimethyl ester (624-48-6) 

was moderate via dermal exposure. Data for repeated-dose toxicity data were available for three 
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cluster members. Systemic toxicity was moderate for the lower molecular weight cluster 

members via the dermal (624-48-6) and oral (623-91-6 and by extension 141-05-9) routes of 

exposure. Systemic toxicity was low via oral exposure for 2-butenedioic acid (2Z)-, 1,4-dibutyl 

ester (105-76-0) and by extension the other mid-range (C16-C20) cluster members (105-52-2 

(C16), 142-16-5 (C20), 141-02-6(C20)). Although data is generally lacking for the higher 

molecular weight cluster members, those chemicals with log Kows above 12, are expected to have 

poor or no absorption and therefore limited toxicity. 

Developmental toxicity for 2-butenedioic acid (2Z)-, 1,4-dibutyl ester (105-76-0) was low via the 

oral route of exposure. Low developmental toxicity is expected for those mid-range cluster 

members for which the 2-butenedioic acid (2Z)-, 1,4-dibutyl ester (105-76-0) data was readacross (105-52-2 (C16), 142-16-5 (C20), 141-02-6(C20)). Reproductive toxicity data were 

available for two cluster members. Reproductive toxicity of 2-butenedioic acid (2Z)-, 1,4-

dibutyl ester (105-76-0) was low following oral exposure and is also expected to be low for other 

cluster members to which this data was read-across (105-52-2 (C16), 142-16-5 (C20), 141-02-

6(C20)). Also, 2-butenedioic acid (2E)-, 1,4-diethyl ester (623-91-6) did not cause effects on 

reproduction. 

Measured data available for eye and skin irritation show mixed results. 2-Butenedioic acid (2Z)-

, dimethyl ester (624-48-6) was irritating to eyes and skin in rabbits. Butenedioic acid (2Z)-, 1,4-

dibutyl ester (105-76-0) was irritating to eyes of rabbits but not to skin of rats and 2-butenedioic 

acid (2Z)-, 1,4-bis(2-ethylhexyl) ester (142-16-5) was not irritating to eyes in rabbits, but was a 

skin irritant in rabbits. Skin sensitization was reported in guinea pigs for both 2-butenedioic acid 

(2Z)-, dimethyl ester (624-48-6) and 2-butenedioic acid (2Z)-, 1,4-dibutyl ester (105-76-0). 

Mixed results were reported from genotoxicity studies for members of this cluster. Mutagenic 

effects were reported for 2-butenedioic acid (2Z)-, 1,4-diethyl ester (141-05-9) in an in vitro gene 

mutation test conducted on mouse lymphoma cells and for 2-butenedioic acid (2E)-, 1,4-diethyl 

ester (623-91-6) in in vitro chromosome aberration study. However, 2-butenedioic acid (2Z)-, 

dimethyl ester (624-48-6) and 2-butenedioic acid (2Z)-, 1,4-dibutyl ester (105-76-0) were 

negative in both chromosome aberrations in mice and in vitro mutagenicity tests. No measured 

carcinogenicity data are available for the members of this cluster and the chemicals in this cluster 

are not covered in the current version of OncoLogic. Expert judgment suggests low concern for 

the larger molecular weight members and at most a marginal cancer potential for the smaller 

molecular weight members of the cluster which may, under unusual conditions, undergo 

reduction reactions subsequently resulting in cyclization to form unsaturated lactones. 

6. OVERALL HAZARD CHARACTERIZATION SUMMARY (Table D) 

Persistence and Bioaccumulation: Available experimental and estimated data for butenedioic 

acid dialkyl esters indicate that members of this cluster are anticipated to have low persistence 

and low bioaccumulation. 

Environment: Available experimental and estimated data indicate that acute and chronic toxicity 

of butenedioic acid dialkyl esters to aquatic organisms ranges from low to high in a trend that is 

predictable based on log Kow and water solubility. Butenedioic acid dialkyl esters with log Kows 

above 8 are not expected to be toxic due to their low water solubility. 
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Human Health: Available experimental and estimated data indicate the acute toxicity for the 

butenedioic acid dialkyl esters cluster via oral exposure is low and via dermal exposure may be 

moderate. Repeated-dose toxicity ranges from moderate to low, apparently decreasing with 

increasing molecular size (and associated properties). Reproductive and developmental toxicity 

for the cluster members is considered low based on available data and is consistent with 

conclusions drawn from a larger category of diesters previously assessed (U.S. EPA, 2008). 

Mixed results were reported for eye and skin irritation suggest that lower molecular weight 

butenedioic acid dialkyl esters are expected to be eye and skin irritants, but do not support 

identification of a trend as molecular weight and log Kow increase. Positive indications of skin 

sensitization were seen for low and mid-range molecular weight cluster members. Mixed results 

were also reported for genotoxicity. The overall carcinogenicity concern is expected to be low. 

7. 2006 NON-CBI IUR INFORMATION 

IUR Information for the Moderate Production Volume (MPV) Butenedioic acid dialkyl 

esters (CASRN 141-02-6, 141-05-9, 624-48-6, 2915-52-6, 14234-82-3, 53817-54-2, 6179-19-2) 

2-Butenedioic acid (2E)-, 1,4-bis(2-ethylhexyl) ester (141-02-6): According to the 2006 IUR 

submissions, 2-Butenedioic acid (2E)-, 1,4-bis(2-ethylhexyl) ester had aggregated production 

and/or import volume(s) in the United States between 25,000 and 500,000 pounds. No industrial 

processing and uses were reported in the IUR submissions for this chemical. Also, no 

commercial and consumer uses were reported in the IUR submissions for this chemical. 

2-Butenedioic acid (2Z)-, 1,4-diethyl ester (141-05-9): According to the 2006 IUR submissions, 

2-Butenedioic acid (2Z)-, 1,4-diethyl ester had aggregated production and/or import volume(s) in 

the United States between 25,000 and 500,000 pounds. No industrial processing and uses were 

reported in the IUR submissions for this chemical. Also, no commercial and consumer uses were 

reported in the IUR submissions for this chemical. 

2-Butenedioic acid (2Z)-, 1,4-dimethyl ester (624-48-6): According to the 2006 IUR 

submissions, 2-Butenedioic acid (2Z)-, 1,4-dimethyl ester had aggregated production and/or 

import volume(s) in the United States between 25,000 and 500,000 pounds. No industrial 

processing and uses were reported in the IUR submissions for this chemical. Also, no 

commercial and consumer uses were reported in the IUR submissions for this chemical. 

2-Butenedioic acid (2Z)-, 1,4-didodecyl ester (2915-52-8): According to the 2006 IUR 

submissions, 2-Butenedioic acid (2Z)-, 1,4-didodecyl ester had aggregated production and/or 

import volume(s) in the United States between 25,000 and 500,000 pounds. No industrial 

processing and uses were reported in the IUR submissions for this chemical. Also, no 

commercial and consumer uses were reported in the IUR submissions for this chemical. 

2-Butenedioic acid (2Z)-, 1,4-bis(2-methylpropyl) ester (14234-82-3): According to the 2006 

IUR submissions, 2-Butenedioic acid (2Z)-, 1,4-bis(2-methylpropyl) ester had aggregated 

production and/or import volume(s) in the United States between 25,000 and 500,000 pounds. 

No industrial processing and uses were reported in the IUR submissions for this chemical. Also, 

no commercial and consumer uses were reported in the IUR submissions for this chemical. 
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2-Butenedioic acid (2Z)-, 1,4-diisononyl ester (53817-54-2): According to the 2006 IUR 

submissions, 2-Butenedioic acid (2Z)-, 1,4-diisononyl ester had aggregated production and/or 

import volume(s) in the United States between 25,000 and 500,000 pounds. No industrial 

processing and uses were reported in the IUR submissions for this chemical. Also, no 

commercial and consumer uses were reported in the IUR submissions for this chemical. 

2-Butenedioic acid (2Z)-, 1,4-ditridecyl ester (61791-92-2): According to the 2006 IUR 

submissions, 2-Butenedioic acid (2Z)-, 1,4-ditridecyl ester had aggregated production and/or 

import volume(s) in the United States between 25,000 and 500,000 pounds. No industrial 

processing and uses were reported in the IUR submissions for this chemical. Additionally, no 

commercial and consumer uses were reported in the IUR submissions for this chemical. 

IUR Information for the High Production Volume (HPV) Butenedioic acid dialkyl esters 

(CASRN 621-13-6, 68610-90-2, 68921-51-7) 

2-Butenedioic acid (2Z)-, 1,4-dicyclohexyl ester (621-13-6): According to the 2006 IUR 

submissions, 2-Butenedioic acid (2Z)-, 1,4-dicyclohexyl ester had aggregated production and/or 

import volume(s) in the United States between 1 and 10 million pounds. Non-confidential 

industrial processing and uses reported in the IUR submissions for this chemical include 

intermediate in other basic organic chemical manufacturing. 

Non-confidential commercial and consumer uses were reported as “other”. 

2-Butenedioic acid (2E)-, di-C8-18-alkyl esters (686140-90-2): According to the 2006 IUR 

submissions, 2-Butenedioic acid (2E)-, di-C8-18-alkyl esters had aggregated production and/or 

import volume(s) in the United States between 1 and 10 million pounds. Non-confidential 

industrial processing and uses reported in the IUR submissions for this chemical include 

lubricant in other basic organic chemical manufacturing. 

No commercial and consumer uses were reported in the IUR submissions for this chemical. 

2-Butenedioic acid (2E)-, di-C12-18-alkyl esters (68921-51-7): According to the 2006 IUR 

submissions, 2-Butenedioic acid (2E)-, di-C12-18-alkyl esters had aggregated production and/or 

import volume(s) in the United States between 1 and 10 million pounds. Non-confidential 

industrial processing and uses reported in the IUR submissions for this chemical include 

lubricant in other basic organic chemical manufacturing. 

No commercial and consumer uses were reported in the IUR submissions for this chemical. 

8. REGULATORY AND RELATED INFORMATION SUMMARY

• All cluster members are listed on the TSCA Inventory and are not otherwise regulated under 

TSCA. 

• One cluster member, 2-butenedioic acid (2E)-, di-C8-18-alkyl esters (686140-90-2), was 

included in a TSCA section 8(a) reporting rule for voluntary HPV challenge orphan 

chemicals, resulting in a requirement at 40 CFR §712.30 for submission of a Preliminary 
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Assessment Information Manufacturers Report by November 28, 2006. This chemical will 

continue to be the subject of follow-up by EPA under the orphan strategy described in 

Appendix 5 of the HPV Challenge Report.5

9. INITIAL PRIORITIZATION DECISION FOR: 

MPV Chemical(s)

CAS Registry Number CA Index Name

141-02-6 2-Butenedioic acid (2E)-, 1,4-bis(2-ethylhexyl) ester 

141-05-9 2-Butenedioic acid (2Z)-, 1,4-diethyl ester 

2915-52-8 2-Butenedioic acid (2Z)-, 1,4-didodecyl ester 

14234-82-3 2-Butenedioic acid (2Z)-, 1,4-bis(2-methylpropyl) ester 

53817-54-2 2-Butenedioic acid (2Z)-, 1,4-diisononyl ester 

61791-92-2 2-Butenedioic acid (2Z)-, 1,4-ditridecyl ester 

624-48-6 2-Butenedioic acid (2Z)-, 1,4-dimethyl ester 

HPV Chemical(s)

CAS Registry Number CA Index Name

621-13-6 2-Butenedioic acid (2Z)-, 1,4-dicyclohexyl ester 

68610-90-2 2-Butenedioic acid (2E)-, di-C8-18-alkyl esters 

68921-51-7 2-Butenedioic acid (2E)-, di-C12-18-alkyl esters 

Rationale and Uncertainties Considered in Prioritization Decision:

• Available estimated and experimental data indicate moderate to high acute and chronic 

aquatic toxicity for 141-05-9, 623-91-6, 14234-82-3, 105-76-0, 621-13-6, 105-52-2, 141-02-

6, and 142-16-5. Recognizing the low persistence and low bioaccumulation potential for 

these chemicals, information concerning frequency of releases to water and resultant 

exposures would be useful in determining the extent of potential concern for aquatic 

organisms. 

 

5 Status and Future Directions of the High Production Volume Challenge Program US EPA, HPV Challenge 

Program Report: http://www.epa.gov/hpv/pubs/general/hpvreport.pdf
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• Measured data indicate many members are expected to be irritating to the eyes and skin and 

skin sensitizers. The lowest molecular weight cluster member (624-48-6) showed moderate 

acute toxicity via the dermal route in rabbits and moderate repeated-dose toxicity via the 

dermal route in rats. This chemical also has a moderate vapor pressure. Additionally, 

chemical 623-91-6 showed moderate repeated-dose toxicity via the oral route in rats. 

Information received for cluster member 2-butenedioic acid (2E)-, di-C8-18-alkyl esters 

(686140-90-2) under 40 CFR §712.30 confirmed the chemical’s HPV status and indicated 

that there may be substantial consumer exposure. Therefore, information concerning 

occupational exposures and use of all the cluster members in consumer products would be 

useful in determining the extent of potential concern for workers, consumers and children. 

Prioritization Decision: 

HIGH PRIORITY: Need exposure information to determine next steps. 

• Recognizing the potential concerns for ecotoxicity for specific members of the cluster along 

with concerns for many human health effects and mixed results from current toxicity studies, 

the chemicals in this cluster, with the exception of 2-butenedioic acid (2E)-, di-C8-18-alkyl 

esters (686140-90-2) should be referred to the Interagency Testing Committee (ITC) as 

candidates for the collection of exposure-related information and unpublished health and 

safety studies. 

• Review of exposure data for the other cluster members may allow EPA to determine whether 

additional toxicity data may be warranted. 
If no units provided - endpoint is unitless

Next 6

Table A P-Chem Properties and Environmental Fate

Butenedioic acid dialkyl esters (14)

State Liquid Liquid Liquid Liquid Liquid Solid Liquid LiquidMelting Point (oC) -19 -10.46 0.2 <-60 80Boiling Point (oC) 205 223 218 254.3 277 (d) 168 290 >370

Vapor Pressure (hPa at 25oC) 0.28 0.14 2.6 0.03 >0.0075 0.63 0.004 <4.8E-05

Water Solubility (mg/L) 80000 1400 3100 30 173 0.17 0.159 <0.0025

log Kow 0.8 2.2 2.12 4 3.38 5.8 5.8 >8.1Koc 10 10 10 74 110 1200 640 13000pKA/pKB

HLC (atm-m3/mole) 7.1E-07 2.4E-07 2.4E-07 1.4E-07 3.7E-07 1.4E-08 2.4E-06 1.5E-06

Hydrolysis 50%/120d 50%/100d 50%/10d 50%/190d 50%/120d 50%/420d 50%/4500d 50%/270dPhotolysis 50%/2.2d 50%/2818d 50%/6.9d

Photooxidation (halflife days) 1.5 1.1 0.96 0.67 0.67 0.35 0.46 0.38

Readily Biodeg Yes Yes Yes Yes Yes Yes Yes YesRapid Biodeg Yes Yes Yes Yes Yes Yes Yes YesUltimate Biodeg weeks weeks weeks weeks days- weeks weeks weeks days- weeksAerobic Biodeg 90%/8d 98%/28d 95%/19d 67%/28dAnaerobic Biodeg

Other FateFugacity

Air (%) 2.4 0.42 1.6 0.9 1.8 0.18 0.93 1.3

Water (%) 38 32 37 26 28 18 25 27Soil (%) 60 67 62 73 70 81 74 71Sediment (%) 0.09 0.07 0.08 0.13 0.15 0.74 0.57 0.9

BCF 3.2 13 13 206 111.61 2901 3300 986BAF 1 3 2.8 13 8.7 58 35 10

CASRN 624-48-6 141-05-9 623-91-6 14234-82-3 105-76-0 621-13-6 105-52-2 68610-90-2Molecular Weight 144.1283 172.178 172.178 228.285 228.285 280.3673 284.391 340.497

Production Volume
If no units provided - endpoint is unitless

Previous 8

Table A P-Chem Properties and Environmental FateButenedioic acid dialkyl esters (14)

CASRN 141-02-6 142-16-5 53817-54-2 2915-52-8 61791-92-2 68921-51-7Molecular Weight 340.497 340.497 368.551 452.71 480.763 536.87

Production Volume

State Liquid Liquid Liquid Solid Solid SolidMelting Point (oC) -10 -60 28Boiling Point (oC) 364.8 338.6 380 423.2 490 >540

Vapor Pressure (hPa at 25oC) 7.9E-05 0.01 2.9E-05 2.8E-06 8.5E-09 <1.8E-10Water Solubility (mg/L) 100 12.8 3.4E-04 2.3E-07 7.5E-09 <6.9E-11log Kow 7.9 7.88 8.9 12 13 >15Koc 14000 11000 30000 1600000 5200000 57000000pKA/pKB

HLC (atm-m3/mole) 7.3E-06 7.32E-06 4.5E-06 2.5E-05 4.9E-05 1.9E-04

Hydrolysis 50%/190d 50%/190d 50%/120d 50%/270d 50%/270d 50%/270d

Photolysis 50%/0.2d

Photooxidation (half-life days) 0.36 0.37 0.35 0.28 0.26 0.22

Readily Biodeg Yes Yes Yes Yes Yes YesRapid Biodeg Yes Yes Yes Yes Yes YesUltimate Biodeg days- weeks days- weeks weeks- months weeks weeks weeksAerobic Biodeg 72%/28d

Anaerobic BiodegOther FateFugacity

Air (%) 1.3 1.3 0.322 0.55 0.42 0.38

Water (%) 27 27 18 24 22 22Soil (%) 71 71 81 76 77 77Sediment (%) 1 1.2 0.73 0.02 0.0068 0.00082

BCF 1164 1248 384 46 15 3.2BAF 12 13 3.9 1.6 1.3 0.98
Table B Aquatic Toxicity

Butenedioic acid dialkyl esters (14)

CASRN 624-48-6 141-05-9 623-91-6 14234-82-3 105-76-0 621-13-6 105-52-2 68610-90-2Molecular Weight 144.1283 172.178 172.178 228.285 228.285 280.3673 284.391 340.497Production VolumeState Liquid Liquid Liquid Liquid Liquid Solid Liquid LiquidACUTE

Fish (mg/L) 1293 18 2.4 3.3 1.2 0.14 <1.2 0.000000000016 (NES)

Freshwater fish

Pimephales promelas

Freshwater fish

Freshwater fish

Oncorhynchus mykiss

Freshwater fish

Oncorhynchus mykiss Freshwater fish

96h LC50 96h LC50 72h LC50 96h LC50 96h LC50 96h LC50 96h LC50 96h LC50Neutral Organic SAR

Neutral Organic SAR

Neutral organics

Neutral Organic SAR

Invertebrate (mg/L) 641 11 11 2.4 21 0.13 <21 0.14 (NES)

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna Daphnia magna

48h LC50 72h LC50 72h LC50 48h LC50 48h EC50 48h LC50 48h EC50 48h LC50Neutral Organic SAR

Neutral Organic SAR

Neutral organics

Neutral Organic SAR

Algae (mg/L) 165 1.1 1.1 2.4 6.2 0.26 <6.2 0.14 (NES)

Green Algae Green Algae Green Algae Green Algae Scenedesmus subspicatus Green Algae Scenedesmus subspicatus Green Algae96h EC50 72h EC50 72h EC50 96h EC50 72h LC50 96h EC50 72h EC50 96h EC50Neutral Organic SAR

Neutral Organic SAR

Neutral organics

Neutral Organic SAR

CHRONIC

Fish (mg/L) 126 8.6 10 0.3 1.1 0.013 0.011 0.0000000000011 (NES)

Freshwater fish

Freshwater fish

Freshwater fish

Freshwater fish

Freshwater fish

Freshwater fish

Freshwater fish Freshwater fish

ChV ChV ChV ChV ChV ChV ChV ChVNeutral Organic SAR

Neutral Organic SAR

Neutral Organic SAR

Neutral Organic SAR

Neutral Organic SAR

Neutral Organic SAR

Neutral Organics SAR

Neutral Organic SAR

Invertebrate (mg/L) 47 1.5 1.5 0.31 0.96 0.24 0.021 0.0000000001 (NES)

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna Daphnia magna

ChV 21d EC50 21d EC50 ChV ChV ChV ChV ChVNeutral Organic SAR

Neutral Organic SAR

Neutral Organic SAR

Neutral Organic SAR

Neutral Organic SAR

Neutral Organic SAR

Algae (mg/L) 47 9.4 10 1.2 2.9 0.19 0.11 0.00000013 (NES)

Green Algae Green Algae Green Algae Green Algae Green Algae Green Algae Green Algae Green AlgaeChV ChV ChV ChV ChV ChV ChV ChVNeutral Organic SAR

Neutral Organic SAR

Neutral Organic SAR

Neutral Organic SAR

Neutral Organic SAR

Neutral Organic SAR Acrylates Neutral Organic SAR
Previous 8

Table B Aquatic Toxicity

Butenedioic acid dialkyl esters (14)

CASRN 141-02-6 142-16-5 53817-54-2 2915-52-8 61791-92-2 68921-51-7Molecular Weight 340.497 340.497 368.551 452.71 480.763 536.87Production VolumeState Liquid Liquid Liquid Solid Solid SolidACUTE

Fish (mg/L) <1.2 <1.2 0.00039 (NES) 0.0000012 (NES) 0.00000018 (NES) 0.000000000000058 (NES)

Oncorynchus mykiss

Oncorhynchus mykiss

Freshwater fish

Freshwater fish

Freshwater fish Freshwater fish

96h LC50 96h LC50 96h LC50 96h LC50 96h LC50 96h LC50

Neutral organics

Neutral organics

Neutral organics

Neutral Organic SAR

Invertebrate (mg/L) <21 <21 0.00052 (NES) 0.0000022 (NES) 0.0000004 (NES) 0.00000000000034 (NES)

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna Daphnia magna

48h LC50 48h EC50 48h LC50 48h LC50 48h LC50 48h LC50

Neutral organics

Neutral organics

Neutral organics

Neutral Organic SAR

Algae (mg/L) <6.2 <6.2 0.004 (NES) 0.000059 (NES) 0.000015 (NES) 0.00000000033 (NES)

Scenedesmus subspicatus

Scenedesmus subspicatus Green Algae Green Algae Green Algae Green Algae

72h LC50 72h EC50 96h EC50 96h EC50 96h EC50 96h EC50

Neutral organics

Neutral organics

Neutral organics

Neutral Organic SAR

CHRONIC

Fish (mg/L) 0.0002 0.00023 0.000032 (NES) 0.000000088 (NES) 0.000000014 (NES) 3.7E-15 (NES)

Freshwater fish

Freshwater fish

Freshwater fish

Freshwater fish

Freshwater fish Freshwater fish

ChV ChV ChV ChV ChV ChVNeutral organics

Neutral organics

Neutral organics

Neutral organics

Neutral organics

Neutral Organic SAR

Invertebrate (mg/L) 0.3 0.3 0.00016 (NES) 0.0000012 (NES) 0.00000026 (NES) 0.00000000000087 (NES)

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna Daphnia magna

21d LOEC 21d LOEC ChV ChV LC50 ChV

Neutral organics

Neutral organics

Neutral organics Neutral Organic AR

Algae (mg/L) 0.015 0.017 0.005 (NES) 0.00013 (NES) 0.000042 (NES) 0.0000000038 (NES)

Green Algae Green Algae Green Algae Green Algae Green Algae Green AlgaeChV ChV ChV ChV ChV ChVNeutral organics

Neutral organics

Neutral organics

Neutral organics

Neutral organics

Neutral Organic SAR
Next 6

Table C Human Health

Butenedioic acid dialkyl esters (14)

CASRN 624-48-6 141-05-9 623-91-6 14234-82-3 105-76-0 621-13-6 105-52-2 141-02-6Molecular Weight 144.1283 172.178 172.178 228.285 228.285 280.3673 284.391 340.497Production VolumeState Liquid Liquid Liquid Liquid Liquid Solid Liquid LiquidAcute 610 mg/kg 3200 mg/kg 1367 mg/kg 3730 mg/kg 7460 mg/kg 29200 mg/kg

Rabbit Rat Rat Rat Rat Rat

Repeat Dose 60 mg/kg/day 30 mg/kg/day 30 mg/kg/day 300 mg/kg/day 300 mg/kg/day 300 mg/kg/day

Rat Rat Rat Rat Rat Rat28d 6wk 6wk

Reproductive 100 mg/kg/day 100 mg/kg/day 300 mg/kg/day 300 mg/kg/day 300 mg/kg/day

Rat Rat Rat Rat Rat

Developmental 300 mg/kg/day 300 mg/kg/day 300 mg/kg/day

Rat Rat Rat

GenotoxicityCancerEye Irritation

Rabbit Rabbit Rabbit Rabbit

Skin Irritation

Rabbit Rat

Skin Sensitization

Guinea Pig Guinea Pig Guinea Pig Guinea Pig

Other Toxicity
Previous 8

Table C Human Health

Butenedioic acid dialkyl esters (14)

CASRN 142-16-5 68610-90-2 53817-54-2 2915-52-8 61791-92-2 68921-51-7Molecular Weight 340.497 340.497 368.551 452.71 480.763 536.87

Production Volume

State Liquid Liquid Liquid Solid Solid SolidAcute >9440 mg/kg >5000 mg/kg

Rat Rat

Repeat Dose 300 mg/kg/day

Rat

Reproductive 300 mg/kg/day

Rat

Developmental 300 mg/kg/day

Rat

GenotoxicityCancerEye Irritation

Rabbit

Skin Irritation

Rabbit

Skin Sensitization

Guinea Pig

Other Toxicity
Next 6

Table D Overall Hazard Characte

Butenedioic acid dialkyl esters (14)

CASRN 624-48-6 141-05-9 623-91-6 14234-82-3 105-76-0 621-13-6 105-52-2 68Molecular Weight 144.1283 172.178 172.178 228.285 228.285 280.3673 284.391 3Production VolumeState Liquid Liquid Liquid Liquid Liquid Solid Liquid Environmental

Persistence

Bioaccumulation

Aquatic Toxicity

Acute

Chronic

Human Health Effects

Acute Toxicity

Repeated-DoseReproductiveDevelopmentalGenotoxicityCancer HazardEye IrritationSkin IrritationSkin Sensitization
Previous 8

Table D Overall Hazard Characterization

Butenedioic acid dialkyl esters (14)

CASRN 141-02-6 142-16-5 53817-54-2 2915-52-8 61791-92-2 68921-51-7Molecular Weight 340.497 340.497 368.551 452.71 480.763 536.87

Production Volume

State Liquid Liquid Liquid Solid Solid SolidEnvironmental

Persistence

Bioaccumulation

Aquatic Toxicity

Acute

Chronic

Human Health Effects

Acute Toxicity

Repeated-DoseReproductiveDevelopmentalGenotoxicityCancer HazardEye IrritationSkin IrritationSkin Sensitization
U.S. Environmental Protection Agency March 2009 

Hazard-Based Prioritization 

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REFERENCES

PCHEM/FATE 

Melting Point

105760 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

141026 PhysProp 

141059 Beilstein Crossfire 

142165 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

621136 Beilstein Crossfire 

623916 OECD 1996 SIAR and SIAP: 

http://www.chem.unep.ch/irptc/sids/OECDSIDS/FUMARATE.pdf 

624486 Beilstein Crossfire 

2915528 Beilstein Crossfire 

Boiling Point

105522 EPISuite ver 4.0 

105760 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

141026 Beilstein Crossfire 

141059 Beilstein Crossfire 

142165 Beilstein Crossfire 

621136 Beilstein Crossfire 

623916 OECD 1996 SIAR and SIAP: 

http://www.chem.unep.ch/irptc/sids/OECDSIDS/FUMARATE.pdf 

624486 Beilstein Crossfire 

2915528 Beilstein Crossfire 

14234823 Beilstein Crossfire 

53817542 EPISuite ver 4.0 

61791922 EPISuite ver 4.0 

68610902 EPISuite ver 4.0 

68921517 EPISuite ver 4.0 
U.S. Environmental Protection Agency March 2009 

Hazard-Based Prioritization 

13

Vapor Pressure

105522 EPISuite ver 4.0 

105760 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

141026 EPISuite ver 4.0 

141059 PhysProp 

142165 IUCLID 

621136 EPISuite ver 4.0 

623916 OECD 1996 SIAR and SIAP: 

http://www.chem.unep.ch/irptc/sids/OECDSIDS/FUMARATE.pdf 

624486 IUCLID 

2915528 EPISuite ver 4.0 

14234823 EPISuite ver 4.0 

53817542 EPISuite ver 4.0 

61791922 EPISuite ver 4.0 

68610902 EPISuite ver 4.0 

68921517 EPISuite ver 4.0 

Water Solubility

105522 PhysProp 

105760 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

141026 PhysProp 

141059 PhysProp 

142165 IUCLID 

621136 EPISuite ver 4.0 

623916 OECD 1996 SIAR and SIAP: 

http://www.chem.unep.ch/irptc/sids/OECDSIDS/FUMARATE.pdf 

624486 IUCLID 

2915528 EPISuite ver 4.0 

14234823 EPISuite ver 4.0 

53817542 EPISuite ver 4.0 
U.S. Environmental Protection Agency March 2009 

Hazard-Based Prioritization 

14

61791922 EPISuite ver 4.0 

68610902 EPISuite ver 4.0 

68921517 EPISuite ver 4.0 

Log Kow

105522 EPISuite ver 4.0 

105760 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

141026 EPISuite ver 4.0 

141059 PhysProp 

142165 IUCLID 

621136 EPISuite ver 4.0 

623916 OECD 1996 SIAR and SIAP: 

http://www.chem.unep.ch/irptc/sids/OECDSIDS/FUMARATE.pdf 

624486 IUCLID 

2915528 EPISuite ver 4.0 

14234823 EPISuite ver 4.0 

53817542 EPISuite ver 4.0 

61791922 EPISuite ver 4.0 

68610902 EPISuite ver 4.0 

68921517 EPISuite ver 4.0 

Koc

105522 EPISuite ver 4.0 

105760 EPISuite ver 4.0 

141026 EPISuite ver 4.0 

141059 EPISuite ver 4.0 

142165 EPISuite ver 4.0 

621136 EPISuite ver 4.0 

623916 EPISuite ver 4.0 

624486 EPISuite ver 4.0 

2915528 EPISuite ver 4.0 
U.S. Environmental Protection Agency March 2009 

Hazard-Based Prioritization 

15

14234823 EPISuite ver 4.0 

53817542 EPISuite ver 4.0 

61791922 EPISuite ver 4.0 

68610902 EPISuite ver 4.0 

68921517 EPISuite ver 4.0 

Henry's Law 

Constant

105522 PhysProp 

105760 PhysProp 

141026 PhysProp 

141059 PhysProp 

142165 PhysProp 

621136 EPISuite ver 4.0 

623916 PhysProp 

624486 PhysProp 

2915528 EPISuite ver 4.0 

14234823 EPISuite ver 4.0 

53817542 EPISuite ver 4.0 

61791922 EPISuite ver 4.0 

68610902 EPISuite ver 4.0 

68921517 EPISuite ver 4.0 

Hydrolysis

105522 EPISuite ver 4.0 

105760 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

141026 EPISuite ver 4.0 

141059 EPISuite ver 4.0 

142165 EPISuite ver 4.0 

621136 EPISuite ver 4.0 

623916 OECD 1996 SIAR and SIAP: 

http://www.chem.unep.ch/irptc/sids/OECDSIDS/FUMARATE.pdf 
U.S. Environmental Protection Agency March 2009 

Hazard-Based Prioritization 

16

624486 EPISuite ver 4.0 

2915528 EPISuite ver 4.0 

14234823 EPISuite ver 4.0 

53817542 EPISuite ver 4.0 

61791922 EPISuite ver 4.0 

68610902 EPISuite ver 4.0 

68921517 EPISuite ver 4.0 

Photolysis

105760 IUCLID 

142165 IUCLID 

623916 OECD 1996 SIAR and SIAP: 

http://www.chem.unep.ch/irptc/sids/OECDSIDS/FUMARATE.pdf 

624486 IUCLID 

Photooxidation

105522 EPISuite ver 4.0 

105760 EPISuite ver 4.0 

141026 EPISuite ver 4.0 

141059 EPISuite ver 4.0 

142165 EPISuite ver 4.0 

621136 EPISuite ver 4.0 

623916 EPISuite ver 4.0 

624486 EPISuite ver 4.0 

2915528 EPISuite ver 4.0 

14234823 EPISuite ver 4.0 

53817542 EPISuite ver 4.0 

61791922 EPISuite ver 4.0 

68610902 EPISuite ver 4.0 

68921517 EPISuite ver 4.0 

Ready 

Biodegradation
U.S. Environmental Protection Agency March 2009 

Hazard-Based Prioritization 

17

105522 EPISuite ver 4.0 

105760 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

141026 EPISuite ver 4.0 

141059 EPISuite ver 4.0 

142165 EPISuite ver 4.0 

621136 EPISuite ver 4.0 

623916 OECD 1996 SIAR and SIAP: 

http://www.chem.unep.ch/irptc/sids/OECDSIDS/FUMARATE.pdf 

624486 EPISuite ver 4.0 

2915528 EPISuite ver 4.0 

14234823 EPISuite ver 4.0 

53817542 EPISuite ver 4.0 

61791922 EPISuite ver 4.0 

68610902 EPISuite ver 4.0 

68921517 EPISuite ver 4.0 

Rapid 

Biodegradation

105522 EPISuite ver 4.0 

105760 EPISuite ver 4.0 

141026 EPISuite ver 4.0 

141059 EPISuite ver 4.0 

142165 EPISuite ver 4.0 

621136 EPISuite ver 4.0 

623916 EPISuite ver 4.0 

624486 EPISuite ver 4.0 

2915528 EPISuite ver 4.0 

14234823 EPISuite ver 4.0 

53817542 EPISuite ver 4.0 

61791922 EPISuite ver 4.0 

68610902 EPISuite ver 4.0 
U.S. Environmental Protection Agency March 2009 

Hazard-Based Prioritization 

18

68921517 EPISuite ver 4.0 

Ultimate 

Biodegradation

105522 EPISuite ver 4.0 

105760 EPISuite ver 4.0 

141026 EPISuite ver 4.0 

141059 EPISuite ver 4.0 

142165 EPISuite ver 4.0 

621136 EPISuite ver 4.0 

623916 EPISuite ver 4.0 

624486 EPISuite ver 4.0 

2915528 EPISuite ver 4.0 

14234823 EPISuite ver 4.0 

53817542 EPISuite ver 4.0 

61791922 EPISuite ver 4.0 

68610902 EPISuite ver 4.0 

68921517 EPISuite ver 4.0 

Aerobic 

Biodegradation

105760 OECD SIAR and SIAP: 

http://www.chem.unep.ch/irptc/sids/OECDSIDS/105760.pdf 

142165 IUCLID 

623916 OECD 1996 SIAR and SIAP: 

http://www.chem.unep.ch/irptc/sids/OECDSIDS/FUMARATE.pdf 

624486 IUCLID 

68610902 IUCLID 

Fugacity

105522 EPISuite ver 4.0 

105760 EPISuite ver 4.0 

141026 EPISuite ver 4.0 

141059 EPISuite ver 4.0 
U.S. Environmental Protection Agency March 2009 

Hazard-Based Prioritization 

19

142165 EPISuite ver 4.0 

621136 EPISuite ver 4.0 

623916 EPISuite ver 4.0 

624486 EPISuite ver 4.0 

2915528 EPISuite ver 4.0 

14234823 EPISuite ver 4.0 

53817542 EPISuite ver 4.0 

61791922 EPISuite ver 4.0 

68610902 EPISuite ver 4.0 

68921517 EPISuite ver 4.0 

BCF

105522 EPISuite ver 4.0 

105760 OECD SIAR and SIAP: 

http://www.chem.unep.ch/irptc/sids/OECDSIDS/105760.pdf 

141026 EPISuite ver 4.0 

141059 EPISuite ver 4.0 

142165 EPISuite ver 4.0 

621136 EPISuite ver 4.0 

623916 EPISuite ver 4.0 

624486 EPISuite ver 4.0 

2915528 EPISuite ver 4.0 

14234823 EPISuite ver 4.0 

53817542 EPISuite ver 4.0 

61791922 EPISuite ver 4.0 

68610902 EPISuite ver 4.0 

68921517 EPISuite ver 4.0 

BAF

105522 EPISuite ver 4.0 

105760 EPISuite ver 4.0 

141026 EPISuite ver 4.0 
U.S. Environmental Protection Agency March 2009 

Hazard-Based Prioritization 

20

141059 EPISuite ver 4.0 

142165 EPISuite ver 4.0 

621136 EPISuite ver 4.0 

623916 EPISuite ver 4.0 

624486 EPISuite ver 4.0 

2915528 EPISuite ver 4.0 

14234823 EPISuite ver 4.0 

53817542 EPISuite ver 4.0 

61791922 EPISuite ver 4.0 

68610902 EPISuite ver 4.0 

68921517 EPISuite ver 4.0 

ECOTOXICITY 

Acute Fish

105522 Read Across based on CASRN 105-76-0 

105760 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

141026 Read Across based on CASRN 105-76-0 

141059 Canada DSL 

142165 Read Across based on CASRN 105-76-0 

621136 ECOSAR v.1.00 

623916 OECD 1996 SIAR and SIAP: 

http://www.chem.unep.ch/irptc/sids/OECDSIDS/FUMARATE.pdf 

624486 ECOSAR v.1.00 

2915528 ECOSAR v.1.00 

14234823 ECOSAR v.1.00 

53817542 ECOSAR v.1.00 

61791922 ECOSAR v.1.00 

68610902 Read Across based on Daphnid 68610-90-2 

68921517 ECOSAR v.1.00 

Acute Daphnid
U.S. Environmental Protection Agency March 2009 

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21

105522 Read Across based on CASRN 105-76-0 

105760 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

141026 Read Across based on CASRN 105-76-0 

141059 Read Across based on 623-91-6 

142165 Read Across based on CASRN 105-76-0 

621136 ECOSAR v.1.00 

623916 OECD 1996 SIAR and SIAP: 

http://www.chem.unep.ch/irptc/sids/OECDSIDS/FUMARATE.pdf 

624486 ECOSAR v.1.00 

2915528 ECOSAR v.1.00 

14234823 ECOSAR v.1.00 

53817542 ECOSAR v.1.00 

61791922 ECOSAR v.1.00 

68610902 ECOSAR v.1.00 

68921517 ECOSAR v.1.00 

Acute Algae

105522 Read Across based on CASRN 105-76-0 

105760 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

141026 ECOSAR v.1.00 

141059 Read Across based on 623-91-6 

142165 ECOSAR v.1.00 

621136 ECOSAR v.1.00 

623916 OECD 1996 SIAR and SIAP: 

http://www.chem.unep.ch/irptc/sids/OECDSIDS/FUMARATE.pdf 

624486 ECOSAR v.1.00 

2915528 ECOSAR v.1.00 

14234823 ECOSAR v.1.00 

53817542 ECOSAR v.1.00 

61791922 ECOSAR v.1.00 
U.S. Environmental Protection Agency March 2009 

Hazard-Based Prioritization 

22

68610902 ECOSAR v.1.00 

68921517 ECOSAR v.1.00 

Chronic Fish

105522 ECOSAR v.1.00 

105760 ECOSAR v.1.00 

141026 ECOSAR v.1.00 

141059 ECOSAR v.1.00 

142165 ECOSAR v.1.00 

621136 ECOSAR v.1.00 

623916 ECOSAR v.1.00 

624486 ECOSAR v.1.00 

2915528 ECOSAR v.1.00 

14234823 ECOSAR v.1.00 

53817542 ECOSAR v.1.00 

61791922 ECOSAR v.1.00 

68610902 ECOSAR v.1.00 

68921517 ECOSAR v.1.00 

Chronic Daphnid

105522 ECOSAR v.1.00 

105760 ECOSAR v.1.00 

141026 Read Across based on 623-91-6 

141059 Read Across based on 623-91-6 

142165 IUCLID 

621136 ECOSAR v.1.00 

623916 OECD 1996 SIAR and SIAP: 

http://www.chem.unep.ch/irptc/sids/OECDSIDS/FUMARATE.pdf 

624486 ECOSAR v.1.00 

2915528 ECOSAR v.1.00 

14234823 ECOSAR v.1.00 

53817542 ECOSAR v.1.00 
U.S. Environmental Protection Agency March 2009 

Hazard-Based Prioritization 

23

61791922 ECOSAR v.1.00 

68610902 ECOSAR v.1.00 

68921517 ECOSAR v.1.00 

Chronic Algae

105522 ECOSAR v.1.00 

105760 ECOSAR v.1.00 

141026 ECOSAR v.1.00 

141059 ECOSAR v.1.00 

142165 ECOSAR v.1.00 

621136 ECOSAR v.1.00 

623916 ECOSAR v.1.00 

624486 ECOSAR v.1.00 

2915528 ECOSAR v.1.00 

14234823 ECOSAR v.1.00 

53817542 ECOSAR v.1.00 

61791922 ECOSAR v.1.00 

68610902 ECOSAR v.1.00 

68921517 ECOSAR v.1.00 

HUMAN HEALTH 

Acute Toxicity

105522 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

105760 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

141026 ChemID 

141059 ChemID 

142165 USEPA, Risk-based Prioritization Doc., Supporting Docs. 2008 

623916 OECD 1996 SIAR and SIAP: 

http://www.chem.unep.ch/irptc/sids/OECDSIDS/FUMARATE.pdf 

624486 ChemID 

68610902 IUCLID 
U.S. Environmental Protection Agency March 2009 

Hazard-Based Prioritization 

24

Repeat Dose 

Toxicity

105522 Read Across from 105-76-0 

105760 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

142165 Read Across from 105-76-0 

141026 Read Across from 105-76-0 

623916 OECD 1996 SIAR and SIAP: 

http://www.chem.unep.ch/irptc/sids/OECDSIDS/FUMARATE.pdf 

624486 IUCLID 

141059 Read Across from 623-91-6 

Reproductive 

Toxicity

105522 Read Across from 105-76-0 

105760 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

142165 Read Across from 105-76-0 

623916 OECD-SIAR 

141059 Read Across from 623-91-6 

141026 Read Across from 105-76-0 

Developmental 

Toxicity

105522 Read Across from 105-76-0 

105760 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

142165 Read Across from 105-76-0 

141026 Read Across from 105-76-0 

Genotoxicity

105522 Read Across from 105-76-0 

105760 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

141059 CCRIS 
U.S. Environmental Protection Agency March 2009 

Hazard-Based Prioritization 

25

142165 Read Across from 105-76-0 

623916 OECD 1996 SIAR and SIAP: 

http://www.chem.unep.ch/irptc/sids/OECDSIDS/FUMARATE.pdf 

624486 IUCLID 

141026 Read Across from 105-76-0 

Skin Irritation

105760 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

142165 IUCLID 

624486 IUCLID 

Eye Irritation

105760 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

142165 IUCLID 

624486 IUCLID 

141026 Read Across from 105-76-0 

105522 Read Across from 105-76-0 

Skin Sensitization

105522 Read Across from 105-76-0 

105760 USEPA 2008 Risk-based Prioritization Document: 

http://www.epa.gov/hpvis/rbp/Cat_Diesters_Web_SuppDocs_Sept2008.pdf

142165 USEPA Read Across from 105-76-0 

624486 IUCLID 

141026 Read Across from 105-76-0