### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460



### December 26

, 201 2

MEMORANDUM

Subject: Transmission of Background Materials for the Session of the January 29

– Febuary 1, 2013 FIFRA Scientific Advisory Panel entitled “ Scientific Issues

Associated with Prioritization of the Endocrine Disruptor Screening Program Universe of Chemicals for an Estrogen Receptor Adverse Outcome Pathway Using Computational Toxicology Tools .”

To: Sharlene Matten

, Ph.D

, Designated Federal Official

FIFRA SAP Office of Science Coordination and Policy ( 7201M )

From: Mary Manibusan

, Director Exposure Assessment, Coordination and Policy Division Office of Science Coordination and Policy ( 720 3 M )

This memo transmits the charge questions, issue paper, and related documents for the January 29

– Febuary 1, 2013 FIFRA Scientific Advisory Panel “ Prioritization of the Endocrine Disruptor Screening Program Universe of Chemicals for an Estrogen Receptor Adverse Outcome Pathway Using Computational Toxicology Tools

. ”

These documents include the White Paper, which is being provided for the Panel’s review, along with reference d materials. Additionally, these documents have been electronically transmitted to you via email.

These documents do not cont ain any information protected under the statute as Confidential Business Information (CBI) or information protected from disclosure to foreign and multi

- national pesticide producers under FIFRA Section 10(g).

The attached CD contain s the documents identif ied in the table below. Please feel free to call upon us if you have any questions.White Paper (Review Document) S ource Author(s) Date FIFRA 10(g)

Protected Prioritization of the Endocrine Disruptor Screening Program Universe of

Chemicals for an Estrogen Receptor Adverse Outcome Pathway Using Computational Toxicology Tools CD

Folder U.S. EPA December 20 12 No

Charge Questions for the Panel CD

Folder U.S. EPA December 20 12 No

Appendix A

EDSP Universe of Chemicals and General Validation Principles CD

Folder U.S. EPA November 2012 No

Appendix B

An Effects

- based Expert System to Predict Estrogen Receptor Binding Affinity for Food Use Inert Ingredients

and Antimicrobial Pesticides: Application in a Prioritization Scheme for Endocrine Disruptor Screeni ng CD

Folder U.S. EPA July 2009 No

Appendix C

SAP Minutes on “An Effects

- based Expert System to Predict Estrogen Receptor Binding Affinity for Food Use Inert Ingredients and Antimicrobial Pesticides: Application in a

Prioritization Scheme for Endocrine Disruptor Screening” CD

Folder U.S. EPA November 2009 No

Appendix D Section 4 Supplemental, Details of Chemical Library CD

Folder U.S. EPA December 2012 No

Appendix E Section 5 Supplemental, HTP Data Processing Pipeline CD

Folder U.S. EPA December 2012 No

Appendix F Section 6 Supplemental, Descriptions of HTP Assays for the Detection of Estrogen Receptor Agonists CD

Folder U.S. EPA December 2012 No

Appendix G Section 7 Supplemental, ERES TrSet

Decision Criteria for Binder/Nonbinder

and Data Collection and Processing

Details CD

Folder U.S. EPA December 2012 No

Appendix H Section 7 Supplemental, Tables CD

Folder U.S. EPA December 2012 No

Appendix I Section 7 Supplemental, Figures CD

Folder U.S. EPA December 2012 No