# Patent

## Title
Method of and apparatus for monitoring for electrode displacement in the

## Abstract

This is a division, of application Ser. No. 440,629, filed Feb. 7, 1974 now Pat. No. 3933889 which is a continuation-in-part of Ser. No. 247993, filed Apr. 27, 1972 now abandoned.

## Background
This invention relates to novel compositions of matter, to novel methods for producing those, and to novel chemical intermediates useful in those processes. Particularly, this invention relates to certain novel analogs of known prostaglandins in which a cis carbon-carbon double bond links C-4 and C-5 in the carboxy-terminated chain.

The essential material for this application, including the background of the invention, the disclosure of the invention, and the description of the preferred embodiments, including Preparations and Examples, is incorporated by reference from U.S. Pat. No. 3,933,889 columns 1-50, inclusive, under the provisions of M.P.E.P. 608.01(p).

It is a purpose of this invention to provide novel 4,5-didehydro PG.sub.1 analogs in which a cis carbon-carbon double bond links C-4 and C-5 in the carboxyterminated chain and in which there is variable chain length, branching, and fluoro substitution in the hydroxysubstituted side chain. It is a further purpose to provide 4,5-didehydro-13,14-dihydro-PG.sub.1 analogs. It is a further purpose to provide esters, lower alkanoates, and pharmacologically acceptable salts of said analogs. It is a further purpose to provide novel processes for preparing these acids and esters. It is still a further purpose to provide novel intermediates useful in said processes.

The presently described acids and esters of the 4,5-unsaturated prostaglandin analogs include compounds of the following formulas, and also the racemic compounds of each respective formula and the mirror image thereof: ##STR1##

In formulas VIII, XII, XVI, and XX, R.sub.1 is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, phenyl substituted with one to 3 chloro or alkyl of one to 4 carbon atoms, inclusive; R.sub.5 is hydrogen, methyl, or ethyl; and R.sub.x is (1) alkyl of 2 to 4 carbon atoms, inclusive, substituted with zero to 2 fluoro, inclusive, (2) branched-chain alkyl of 5 carbon atoms or alkyl of 5 carbon atoms substituted with one or 2 fluoro, or (3) alkyl of 6 to 10 carbon atoms, inclusive, substituted with zero to 2 fluoro, inclusive.

## Claims

1. An optically active compound of the formula ##STR2## or a racemic compound of that formula and the mirror image thereof, wherein M is ##STR3## wherein R.sub.5 is hydrogen, methyl, or ethyl; and wherein R.sub.1 is hydrogen or alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive; including the lower alkanoates thereof, and the pharmacologically acceptable salts thereof when R.sub.1 is hydrogen.

2. A compound according to claim 1 wherein M is ##STR4##

3. 4,5-cis-Didehydro-13,14-dihydro-PGE.sub.1, a compound according to claim 2.

4. 4,5-cis-Didehydro-13,14-dihydro-PGE.sub.1, methyl ester, a compound according to claim 2.

5. An optically active compound of the formula ##STR5## or a racemic compound of that formula and the mirror image thereof, wherein M is ##STR6## wherein R.sub.5 is hydrogen, methyl, or ethyl; wherein R.sub.1 is hydrogen or alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive; wherein R.sub.2 is alkyl of 2 to 4 carbon atoms, inclusive, substituted with one or 2 fluoro; and wherein E is trans--CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --; including the lower alkanoates thereof, and the pharmacologically acceptable salts thereof when R.sub.1 is hydrogen.

6. A compound according to claim 5 wherein any fluoro substitution is at either or both of the C-16 and C-17 carbon atoms.

7. 4,5-cis-Didehydro-16-fluoro-20-nor-PGE.sub.1, a compound according to claim 6.

8. 4,5-cis-Didehydro-16-fluoro-20-nor-PGE.sub.1, methyl ester, a compound according to claim 6.

9. 4,5-cis-Didehydro-16,16-difluoro-20-nor-PGE.sub.1, a compound according to claim 6.

10. 4,5-cis-Didehydro-16,16-difluoro-20-nor-PGE.sub.1, methyl ester, a compound according to claim 6.

11. An optically active compound of the formula ##STR7## or a racemic compound of that formula and the mirror image thereof, wherein M is ##STR8## wherein R.sub.5 is hydrogen, methyl, or ethyl; wherein R.sub.1 is hydrogen or alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive; wherein R.sub.3 is alkyl of 5 carbon atoms substituted with one or 2 fluoro; and wherein E is trans--CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --; including the lower alkanoates thereof, and the pharmacologically acceptable salts thereof when R.sub.1 is hydrogen.

12. A compound according to claim 11 wherein fluoro substitution is at either or both of the C-16 and C-17 carbon atoms.

13. 4,5-cis-Didehydro-16-fluoro-PGE.sub.1, a compound according to claim 12.

14. 4,5-cis-Didehydro-16-fluoro-PGE.sub.1, methyl ester, a compound according to claim 12.

15. 4,5-cis-Didehydro-16,16-difluoro-PGE.sub.1, a compound according to claim 12.

16. 4,5-cis-Didehydro-16,16-difluoro-PGE.sub.1, methyl ester, a compound according to claim 12.

17. An optically active compound of the formula ##STR9## or a racemic compound of that formula and the mirror image thereof, wherein M is ##STR10## wherein R.sub.5 is hydrogen, methyl, or ethyl; wherein R.sub.1 is hydrogen or alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive, wherein R.sub.4 is alkyl of 6 to 10 carbon atoms, inclusive, substituted with one or 2 fluoro; and wherein E is trans--CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --; including the lower alkanoates thereof, and the pharmacologically acceptable salts thereof when R.sub.1 is hydrogen.

18. A compound according to claim 17 wherein fluoro substitution is at either or both of the C-16 and C-17 carbon atoms.

19. 4,5-cis-Didehydro-16-fluoro-20-methyl-PGE.sub.1, a compound according to claim 18.

20. 4,5-cis-Didehydro-16-fluoro-20-methyl-PGE.sub.1, methyl ester, a compound according to claim 18.

21. 4,5-cis-Didehydro-16,16-difluoro-20-methyl-PGE.sub.1, a compound according to claim 18.

22. 4,5-cis-Didehydro-16,16-difluoro-20-methyl-PGE.sub.1, methyl ester, a compound according to claim 18.