UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

December 26, 2012

MEMORANDUM

Subject: Transmission of Background Materials for the Session of the January 29–

Febuary 1, 2013 FIFRA Scientific Advisory Panel entitled “Scientific Issues 

Associated with Prioritization of the Endocrine Disruptor Screening 

Program Universe of Chemicals for an Estrogen Receptor Adverse 

Outcome Pathway Using Computational Toxicology Tools.”

To: Sharlene Matten, Ph.D, Designated Federal Official

FIFRA SAP

Office of Science Coordination and Policy (7201M)

From: Mary Manibusan, Director

Exposure Assessment, Coordination and Policy Division

Office of Science Coordination and Policy (7203M)

This memo transmits the charge questions, issue paper, and related documents for the

January 29–Febuary 1, 2013 FIFRA Scientific Advisory Panel “Prioritization of the 

Endocrine Disruptor Screening Program Universe of Chemicals for an Estrogen 

Receptor Adverse Outcome Pathway Using Computational Toxicology Tools.”

These documents include the White Paper, which is being provided for the Panel’s 

review, along with referenced materials. Additionally, these documents have been 

electronically transmitted to you via email. 

These documents do not contain any information protected under the statute as 

Confidential Business Information (CBI) or information protected from disclosure to 

foreign and multi-national pesticide producers under FIFRA Section 10(g).

The attached CD contains the documents identified in the table below. Please feel free 

to call upon us if you have any questions.
White Paper

(Review Document) Source Author(s) Date

FIFRA 10(g) 

Protected

Prioritization of the Endocrine Disruptor 

Screening Program Universe of 

Chemicals for an Estrogen Receptor 

Adverse Outcome Pathway Using 

Computational Toxicology Tools

CD

Folder U.S. EPA December 2012 No

Charge Questions for the Panel CD

Folder U.S. EPA December 2012 No

Appendix A

EDSP Universe of Chemicals and 

General Validation Principles

CD 

Folder U.S. EPA November 2012 No

Appendix B

An Effects-based Expert System to 

Predict Estrogen Receptor Binding 

Affinity for Food Use Inert Ingredients 

and Antimicrobial Pesticides: 

Application in a Prioritization Scheme 

for Endocrine Disruptor Screening

CD 

Folder U.S. EPA July 2009 No

Appendix C

SAP Minutes on “An Effects-based 

Expert System to Predict Estrogen 

Receptor Binding Affinity for Food Use 

Inert Ingredients and Antimicrobial 

Pesticides: Application in a 

Prioritization Scheme for Endocrine 

Disruptor Screening”

CD 

Folder U.S. EPA November 2009 No

Appendix D

Section 4 Supplemental, Details of 

Chemical Library

CD 

Folder U.S. EPA December 2012 No

Appendix E

Section 5 Supplemental, HTP Data 

Processing Pipeline

CD 

Folder U.S. EPA December 2012 No

Appendix F

Section 6 Supplemental, Descriptions 

of HTP Assays for the Detection of 

Estrogen Receptor Agonists

CD 

Folder U.S. EPA December 2012 No

Appendix G

Section 7 Supplemental, ERES TrSet 

Decision Criteria for Binder/Nonbinder 

and Data Collection and Processing 

Details

CD 

Folder U.S. EPA December 2012 No

Appendix H

Section 7 Supplemental, Tables

CD 

Folder U.S. EPA December 2012 No

Appendix I

Section 7 Supplemental, Figures

CD 

Folder U.S. EPA December 2012 No