Dietary Exposure and Risk Assessment

Thifensulfuron Methyl PC Code 128 8 4 5 DP Barcode D 399156



### Page 3 of 14 departure ( POD), such as the NOAEL or LOAEL, divided by the requisite uncertainty and/ or safety factors

.

For acute and non

- cancer chronic exposures, HED is concerned when estimated dietary risk

exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in

more detail a re available on the EPA pesticides web site, Available Information on Assessing Exposure from Pesticides

, A User’s Guide ( 21 June 2000 )

, which can be accessed via the web

link http://www.epa.gov/fedrgstr/ EPA

- PEST/2000/July/Day

- 12/6061.pdf ( or see SOP 99.6

, dated 20 August 19 99).

The most recent dietary risk assessment for thifensulfuron methyl was conducted by W.T. Drew ( D369038 ; 19 January 2010 ). That assessment appended the previous assessment to include

residue estimates in safflower

, supporting the establishment of a permanent tolerance for thifensulfuron methyl i n th e raw agricultural commodity (RAC ), safflower seeds

. This current

docu ment includes residue es timates in chicory roots and tops (leaves) , supporting the requested

Section 3 registration of thifensulfuron methyl for use on chicory

.

2

. Residue Information

The Interregional Research Project Number 4 (IR

- 4), has submitted a tolerance petition, 1E 7 88 5, proposing the establishment of tolerance s for residues of the herbicide, thifensulfuron methyl, in

or on chicory roots and tops ( the RAC s ) at 0.0 1 ppm

. Permanent t olerances have been

established for thifensulfuron methyl (40CFR §180.43 9 [a] ) in cereal grains (barley, field corn, oat, rice, sorghum, triticale and wheat), canola, cotton, flax and soybeans

. A regional t olerance

ha s been established (40CFR §180.439[ c ]) in safflower seeds

. A list ing of the current tolerances

for residues of thifensulfuron methyl in the various commodities is appended to this document as

Attachment 1 (Table 6). The ROC, for both tolerance enforcement and risk assessment, is the parent compound, thifensulfuron methyl . Both the acute and chronic assessments are highly conservative, and assume 100%CT, along with tolerance

- level residues for all agricultural

commodities. The default processing factor from DEEM 7.81 was used for corn syrup in the analyses.

The lowest limit of method validation (LLMV) was 0.0 1 ppm in chicory roots and tops (leaves)

. T hifensulfuron methyl residues were <LLMV in all samples from both the 1X and 5X field

trials. There are no animal feedstuff s associated with the use on chicory

.

3. Dr inking Water Data

The t hifensulfuron methyl drinking water residue s used in the se dietary risk assessment s w ere provided in Drinking Water Assessments (DWAs) by the Environmental Fate and Effects Division ( EFED )

, and incorporated directly into th e dietary assessment s . Water residues were incorporated in DEEM

- FCID TM via entry into the food categories “water, direct, all sources” and “water, indirect, all sources.”Dietary Exposure and Risk Assessment

Thifensulfuron Methyl PC Code 128 8 4 5 DP Barcode D 399156



### Page 4 of 14 The highest estimated drinking water concentration (EDWC) for acute scenarios was in surface

water

, at 0.0044 ppm. This concentration was derived via utilization of the FQPA Index Reservoir Screening Tool ( FIRST ) model ( D 391089 ; W.J. Shaughnessy ; 12 January 2012 ). The highest EDWC for chronic scenarios was also in surface water

, at 0. 0015 ppm. This concentration was also obtained by utilizing the FIRST model ( D332797; J

. Breithaupt; 26

October 2006 ).

I n order t o be more c onservative, the highest of the acute

, and the highest of the chronic EDWCs (among all t h e various acute and chronic scenarios modeled) were taken from EFED’s two

DWAs

. The acute and chronic EDWCs used in the respective dietary analyses are shown in

bold type in Tables 1 and 2 (below), respectively, along with the other scenarios assessed by

EFED.

TABLE 1 Maximum EDWCs for Drinking Water Risk Assessment, Based upon Ground Application

of Thifensulfuron Methyl. * Drinking Water Source
[Model Used] Use [Rate Modeled] Scenario Maximum EDWC (ppb)

Groundwater [SCIGROW] Safflower [ 0 .0188 lbs ai/A] Acute and Chronic 0.0326 Barley, f allow [ 0 .0 56 lbs ai/A] Acute and Chronic 0.0972
Surface water [FIRST] Safflower [ 0.0188 lbs ai /A ] Acute 1.656

Chronic 0.336 Barley, f allow [ 0.0 56 lbs ai/A] Acute 4.429

Chronic 0.900

* D391089; W.J. Shaughnessy; 12 January 2012

.

TABLE 2 Maximum EDWCs for Drinking Water Risk Assessment, Based upon Aerial Application

of Thifensulfuron Methyl. * Drinking Water Source
[Model Used] Use [Rate Modeled] Scenario Maximum EDWC (ppb)

Surface water [FIRST] Soybean [ 0.032 lbs ai/A] Acute 3.9

Chronic 1.5
* D332797; James Breithaupt; 26 October 2006.



### Th e variou s model s used by EFED in conducting DWAs

, and their description s, are available at

the EPA web site via the web link

, http://www.epa.gov/oppefed1/models/water/

. No surface or ground water monitoring data were available for t hifensulfuron methyl

.

4

. DEEM

- FCIDTM Program and Consumption Information

T hifensulfuron methyl acute and chronic dietary exposure asses sments were conducted using

DEEM

- FCIDTM ( Version 2.03), which incorporates consumption data from USDA’s CSFII,

1994 to 1996

, and 1998. The 1994

- 96, 19 98 data are based on the reported consumption of more

than 20,000 individuals over two non

- consecutive survey days. Foods “as consumed” ( such as apple pie) are linked to EPA

- defined food commodities ( such as apples, peeled fruit

- cooked,Dietary Exposure and Risk Assessment

Thifensulfuron Methyl PC Code 128 8 4 5 DP Barcode D 399156



### Page 5 of 14 fresh/unspecified, or baked; or wheat flour

- cooked, fresh/unspecified, or baked ) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire US population

, and within population subgroups, but for acute exposure assessmen t

, they are retained as individual consumption events (which is why it is appropriate to add residue values together for the acute assessment, while separate exposure estimates are summed for the chronic assessment) . Based on analysis of the 1994

- 96, 19 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general US population, all infants (<1 year old), children 1

- 2, c hildren 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50+ years

old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food

form ( such as orange or orange juice) on the food commodity re sidue list is multiplied by the average daily consumption estimate for that food/food form. The resulting residue consumption estimate for each food/food form is summed with the residue consumption estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day

, and as a percent of the cPAD. This procedure is performed for each population subgroup.

For acute exposure assessments, individual one

- day food consumption data are used on an

individual

- by

- individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate

, and summed to obtain a total daily pesticide exposure for a deterministic exposure asses sment, or “matched” in multiple random pairings with residue

values

, and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (those who reported eating relevant

commodi ties/food forms) and a per

- capita (those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for all levels of refinement of the analysis. However, for analyses which are largely

unrefined , significant differences in user v ersu s per capita exposure and risk are identified

, and

noted in the risk assessment.

5

. Toxicological Information

For detailed information, please refer to the human health risk assessment conducted for

t hifensulfuron methyl use on chicory ( D39 1 0 88 ; W

. T . Dr ew ; 1 June 2012 ). The database adequately characterizes t hifensulfuron methyl as having low (Category III or IV) acute oral, dermal and inhalation toxicity

. The data show moderate eye irritation (Category III)

, and slight dermal irritation (Category IV). Thifensulfuron methyl is not a dermal sensitizer.

The risk assessment team evaluated the toxicology database for thifensulfuron methyl

, and selected doses and endpoints for acute and chronic dietary exposure risk assessments. The acute and chronic dietary reference doses and PADs are summarized in Table 3 (below). The riskDietary Exposure and Risk Assessment

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### Page 6 of 14 assessment team a lso evaluated the potential for increased susceptibility of infants and children from exposure to thifensulfuron methyl. The team concluded that the FQPA Safet y Factor
should be reduced to 1X, as there are no residual uncertainties for pre

- or post

- natal toxicity.

Thifensulfuron methyl was classified as not likely to be a human carcinogen

, based on the lack of evidence of carcinogenicity in both the rat and the mouse

. T herefore, cancer dietary risk is

not of concern

.

TABLE 3 Summary of Thifensulfuro n Methyl Toxicological Doses and Endpoints for Use in Dietary

Exposure and Risk Assessments.
Exposure/

Scenario Point of

Departure Uncertainty/FQPA

Safety Factors L O C for Risk

Assessment Study and Toxicological Effects

Acute d ietary ( females 13

- 49 only ) NOAEL =

159 mg/kg/day UF A = 10X

UF H = 10 X FQPA SF = 1 aRfD = 1.59

mg/kg/day

aPAD = 1.59 mg/kg/day Developmental o ral t oxicity in r ats.

LOAEL = 725 mg/kg/day, based on decreased mean body weight

, and

increased incidence of small renal papillae.

Chronic d ietary (a ll populations ) NOAEL =

4.3 mg/kg/day UF A = 10X

UF H = 10X FQPA SF = 1 cRfD = 0.043

mg/kg/day

cPAD = 0.043 mg/kg/day Carcinogenicity o ral t oxicity in m ice.

LOAEL = 128 mg/kg/day

, based on decreased body weight and body weight gain.
Cancer (oral) Not likely to be a human carcinogen

, based on the lack of evidence of carcinogenicity in rats

and mice.
Point of Departure (POD) = a data point or estimated point derived from observed dose

- response data

, which is used to mark the beginning of extrapolation to determine risk associa ted with lower environmentally relevant human

exposures. UF = Uncertainty Factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity among members of the human population (intraspecies). UF DB = database uncertainty factor to account for the absence of key data ( such as the lack of a critical study). FQPA SF = FQPA Safety Factor.

NOAEL = No Observ ed Adverse Effect Level. LOAEL = Lowest Observed Adverse Effect Level. PAD = Population Adjusted Dose (a = acute, c = chronic). RfD = Reference Dose. MOE = Margin Of Exposure. LOC =

Level Of Concern.



### 6

. Results/Discussion

As previously stated , for acute and chronic assessments, HED is concerned when dietary risk

exceeds 100% of the PAD. The DEEM

- FCIDTM analyses estimate the dietary exposure of the US population

, and various population subgroups. The results of the acute analysi s are summarized in Table 4 (below) for females 13

- 49 years of age

, the only subgroup for which an acute dietary endpoint was identified . As shown in Table 4 , the risk estimate associated with acute dietary exposure to t hifensulfuron methyl is below HED’s LOC

. T he acute dietary risk

estimate at the 95 th 

### percentile of exposure is less than 1% of the aPAD for females 13

- 49

.Dietary Exposure and Risk Assessment

Thifensulfuron Methyl PC Code 128 8 4 5 DP Barcode D 399156



### Page 7 of 14 TABLE 4 Summary of Acute Dietary Exposure and Risk Estimates for Thifensulfuron Methyl

. Population Subgroup [Years of Age] DEEM Acute Dietary Analysis (95 th Percentile)

aPAD (mg/kg/day) Exposure Estimate (mg/kg/day) % aPAD

General US Population NA * NA NA

All Infants [< 1]

Children [1

- 2]

Children [3

- 5]

Children [6

- 12]

Youths [13

- 19]

Adults [20

- 49]

Adults [50+]

Females [13

- 49] 1.59 0.000544 <1

* NA = Not Applicable

.



### The results of the chronic analysis are summarized in Table 5 (below) for the general US

p opulation, all infants (< 1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19,

females 13

- 49, adults 20

- 49, and adults 50+ years. Chronic dietary risk estimates are less than or equal to 1 .4 % of the cPAD for all population subgroups

, as shown in Table 5 . Children 3 to 5 years of age are the most highly

- exposed subgroup.

TABLE 5 Summary of Chronic Dietary Exposure and Risk Estimates for Thifensulfuron Methyl

. Population Subgroup* [Years of Age] DEEM Chronic Dietary Analysis cPAD (mg/kg/day) Exposure Estimate (mg/kg/day) % cPAD

General US Population 0.043 0.000284 < 1

All Infants [<1] 0.000487 1 .1

Children [1

- 2] 0.000602 1 .4

Children [3

- 5] 0.000621 1 .4

Children [6

- 12] 0.000447 1 .0

Youth [13

- 19] 0.000310 < 1

Adults [20

- 49] 0.000239 < 1

Adults [50+] 0.000175 <1

Females [13

- 49] 0.000226 < 1

* Values for the population subgroup with the highest risk are in bold type

.



### All acute and chronic dietary risk estimates are below HED’s LOC.

7

. Characterization of Inputs/Outputs

This assessment is based on tolerance

- level residues in all agricultural commodities , and assumes that all crops with existing or proposed tolerances are treated ( 100%CT) . These assumptions result in highly conservative, health

- protective estimates of dietary exposure and risk.Dietary Exposure and Risk Assessment

Thifensulfuron Methyl PC Code 128 8 4 5 DP Barcode D 399156



### Page 8 of 14 8

. Conclusions

There are no dietary exposure considerations that would preclude the establishment of permanent

tolerance s for residues of t hif ensulfuron methyl in/on chicory roots and tops (leaves)

.

9

. List of Attachments

Attachment 1. Established Tolerances for Residues of Thifensulfuron Methyl.

Attachment 2

. Thifensulfuron Methyl Residues Used for Acute Dietary Exposure Estimates.

Attachment 3

. Summary of the Acute Dietary Exposure and Risk Estimates for Thifensulfuron

Methyl

. Attachment 4

. Thifensulfuron Methyl Residues Used for Chronic Dietary Exposure Estimates.

Attachment 5

. Summary of the Chronic Dietary Exposure and Ris k Estimates for Thifensulfuron

Methyl

.Dietary Exposure and Risk Assessment

Thifensulfuron Methyl PC Code 128 8 4 5 DP Barcode D 399156



### Page 9 of 14 Attachment 1. Established Tolerances for Residues of Thifensulfuron Methyl.

TABLE 6 Established Tolerances for Residues of

Thifensulfuron Methyl.
Commodity Parts Per Million
Barley, grain 0.05 Barley, hay 0.8 Barley, straw 0.10
Canola, seed 0.02 Corn, field, forage 0.10 Corn, field, grain 0.05
Corn, field, stover 0.10 Cotton, gin byproducts 0.02
Cotton, undelinted seed 0.02

Flax, seed 0.02 Oat, forage 0.2 Oat, grain 0.05 Oat, hay 0.05

Oat, straw 0.10 Rice, grain 0.05
Rice, straw 0.05 Sorghum, grain, forage. 0.05 Sorghum, grain, grain 0.05 Sorghum, grain, stover 0.05 Soybean 0.10 Wheat, forage 2.5 Wheat, grain 0.05 Wheat, hay 0.7

Wheat, straw 0.10
Safflower, seed * 0.05
* Regional registration.



### Attachment 2

. Thifensulfuron Methyl Residues Used for Acute Dietary Exposure

Estimates

.

US Environmental Protection Agency

DEEM

- FCID Ver sion 2.03 (1994

- 1996, 19 98 data)

Filename: ThifensulfuronMethylDEEM 022 1 1 2AcuteInput.R98

Chemical: Thifensulfuron methyl

R e f erence D ose (Acute) = 1.59 mg/kg body w eigh t /day

NO A EL (Acute) = 159 mg/kg body w eigh t /day

Date created/last modified: 2 / 21 / 2012 at 14:15:38

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment

Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 15000250 15 Barley, pearled barley 0.050000 1.000 1.000
15000251 15 Barley, pearled barley

- babyfood 0.050000 1.000 1.000
15000260 15 Barley, flour 0.050000 1.000 1.000Dietary Exposure and Risk Assessment

Thifensulfuron Methyl PC Code 128 8 4 5 DP Barcode D 399156



### Page 10 of 14 15000261 15 Barley, flour

- babyfood 0.050000 1.000 1.000
15000270 15 Barley, bran 0.050000 1.000 1.000

01011000 1AB Ch icory, roots 0.010000 1.000 1.000 1E7885
02001010 2 Chicory, tops 0.010000 1.000 1.000 1E7885
15001200 15 Corn, field, flour 0.050000 1.000 1.000
15001201 15 Corn, field, flour

- ba byfood 0.050000 1.000 1.000
15001210 15 Corn, field, meal 0.050000 1.000 1.000
15001211 15 Corn, field, meal

- babyfood 0.050000 1.000 1.000
15001220 15 Corn, field, bran 0.050000 1.000 1.000
15001230 15 Corn, field, starch 0.050000 1.000 1.000
15001231 15 Corn, field, starch

- babyfood 0.050000 1.000 1.000
15001240 15 Corn, field, syrup 0.050000 1.500 1.000
15001241 15 Corn, fi eld, syrup

- babyfood 0.050000 1.500 1.000
15001250 15 Corn, field, oil 0.050000 1.000 1.000
15001251 15 Corn, field, oil

- babyfood 0.050000 1.000 1.000
95001280 O Cottonseed, oil 0.02 0000 1.000 1.000
95001281 O Cottonseed, oil

- babyfood 0.020000 1.000 1.000
20001630 20 Flaxseed, oil 0.020000 1.000 1.000
15002310 15 Oat, bran 0.050000 1.000 1.000

15002320 15 Oat, flour 0.050000 1.000 1.000
15002321 15 Oat, flour

- babyfood 0.050000 1.000 1.000 15002330 15 Oat, groats/rolled oats 0.050000 1.000 1.000 15002331 15 Oat, groats/rolled oats

- ba byfood 0.050000 1.000 1.000
20003190 20 Rapeseed, oil 0.020000 1.000 1.000
20003191 20 Rapeseed, oil

- babyfood 0.020000 1.000 1.000
15003230 15 Rice, white 0.050000 1.000 1.000
15003231 15 Rice, white

- babyfood 0.050000 1.000 1.000
15003240 15 Rice, brown 0.050000 1.000 1.000
15003241 15 Rice, brown

- babyfood 0.050000 1.000 1.000
15003250 15 Rice, flo ur 0.050000 1.000 1.000
15003251 15 Rice, flour

- babyfood 0.050000 1.000 1.000
15003260 15 Rice, bran 0.050000 1.000 1.000
15003261 15 Rice, bran

- babyfood 0.050 000 1.000 1.000
20003300 20 Safflower, oil 0.050000 1.000 1.000
20003301 20 Safflower, oil

- babyfood 0.050000 1.000 1.000
15003440 15 Sorghum, grain 0.050000 1.000 1.000

15003450 1 5 Sorghum, syrup 0.050000 1.000 1.000
06003470 6 Soybean, seed 0.100000 1.000 1.000
06003480 6 Soybean, flour 0.100000 1.000 1.000
06003481 6 Soybean, flour

- babyfood 0.100000 1.000 1.000
06003490 6 Soybean, soy milk 0.100000 1.000 1.000
06003491 6 Soybean, soy milk

- babyfood or in 0.100000 1.000 1.000
06003500 6 Soybean, oil 0.100000 1.000 1.000
06003501 6 Soybean, oil

- babyfood 0.100000 1.000 1.000
86010000 O Water, direct, all sources 0.004429 1.000 1.000
86020000 O Water, indirect, all sources 0.004429 1.000 1.000
15004010 15 Wheat, grain 0.050000 1.000 1.000
15004011 15 Wheat, grain

- babyfood 0.050000 1.000 1.000
15004020 15 Wheat, flour 0.050000 1.000 1.000
15004021 15 Wheat, flour

- babyfood 0.050000 1.000 1.000
15004030 15 Wheat, germ 0.050000 1.000 1.000
15004040 15 Wheat, bran 0.050000 1.000 1.000

15004050 15 Wild rice 0.050000 1.000 1.000Dietary Exposure and Risk Assessment

Thifensulfuron Methyl PC Code 128 8 4 5 DP Barcode D 399156



### Page 11 of 14 Attachment 3

. Summary of the Acute Dietary Exposure and Risk Estimates for

Thifensulfuron Methyl.

US Environmental Protection Agency

DEEM

- FCID Version 2.03 (1994

- 1996, 1998 data)

DEEM

- FCID A cute Analysis for t hifensulfuron methyl
Analysis d ate: 2 / 21 / 2012 at 14:20:43

Residue file: ThifensulfuronMethylDEEM 022112 AcuteInput.R98

Residue file date: 2/21/2012 at 14:15:38

R e f erence D ose (Acute) = 1.59 mg/kg body w eigh t /day NOEL (Acute) = 159 mg/kg body w eigh t/day
Daily totals for food and foodform consumption used.

Run Comment: Adjustment factor #2 NOT used.

==== ============================================================================ ===

Summary calculations (per capita):

95th Percentile 99th Percentile 99.9th Percentile

Exposure %aRfD MOE Exposure %aRfD MOE Exposure %aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Females 13

- 49 yrs:

0.000544 0.03 292150 0.000746 0.05 213279 0.001097 0.07 144880Dietary Exposure and Risk Assessment

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### Page 12 of 14 Attachment 4

. Thifensulfuron Methyl Residues Used for Chronic Dietary Exposure

Estimates

.

US Environmental Protection Agency

DEEM

- FCID Ver sion 2.03 (1994

- 1996, 19 98 data)

Filename: ThifensulfuronMethylDEEM102309ChronicInput.R98

Chemical: Thifensulfuron methyl

RfD (Chronic) = 0 .043 mg/kg body w eigh t /day

NO A EL (Chronic) = 4.3 mg/kg body w eigh t /day

Date created/last modified: 2 / 21 / 2012 at 14:05:53

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment
Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 15000250 15 Barley, pearled barley 0.050000 1.000 1.000
15000251 15 Barley, pearled barley

- babyfood 0.050000 1.000 1.000
15000260 15 Barley, flour 0.050000 1.000 1.000
15000261 15 Barley, flour

- babyfood 0.050000 1.000 1.000
15000270 15 Barley, bran 0.050000 1.000 1.000

01011000 1AB Ch icory, roots 0.010000 1.000 1.000 1E7885
02001010 2 Chicory, tops 0.010000 1.000 1.000 1E7885
15001200 15 Corn, field, flour 0.050000 1.000 1.000
15001201 15 Corn, field, flour

- ba byfood 0.050000 1.000 1.000
15001210 15 Corn, field, meal 0.050000 1.000 1.000
15001211 15 Corn, field, meal

- babyfood 0.050000 1.000 1.000
15001220 15 Corn, field, bran 0.050000 1.000 1.000
15001230 15 Corn, field, starch 0.050000 1.000 1.000
15001231 15 Corn, field, starch

- babyfood 0.050000 1.000 1.000
15001240 15 Corn, field, syrup 0.050000 1.500 1.000
15001241 15 Corn, fi eld, syrup

- babyfood 0.050000 1.500 1.000
15001250 15 Corn, field, oil 0.050000 1.000 1.000
15001251 15 Corn, field, oil

- babyfood 0.050000 1.000 1.000
95001280 O Cottonseed, oil 0.02 0000 1.000 1.000
95001281 O Cottonseed, oil

- babyfood 0.020000 1.000 1.000
20001630 20 Flaxseed, oil 0.020000 1.000 1.000
15002310 15 Oat, bran 0.050000 1.000 1.000

15002320 15 Oat, flour 0.050000 1.000 1.000
15002321 15 Oat, flour

- babyfood 0.050000 1.000 1.000 15002330 15 Oat, groats/rolled oats 0.050000 1.000 1.000 15002331 15 Oat, groats/rolled oats

- ba byfood 0.050000 1.000 1.000
20003190 20 Rapeseed, oil 0.020000 1.000 1.000
20003191 20 Rapeseed, oil

- babyfood 0.020000 1.000 1.000
15003230 15 Rice, white 0.050000 1.000 1.000
15003231 15 Rice, white

- babyfood 0.050000 1.000 1.000
15003240 15 Rice, brown 0.050000 1.000 1.000
15003241 15 Rice, brown

- babyfood 0.050000 1.000 1.000
15003250 15 Rice, flo ur 0.050000 1.000 1.000
15003251 15 Rice, flour

- babyfood 0.050000 1.000 1.000
15003260 15 Rice, bran 0.050000 1.000 1.000
15003261 15 Rice, bran

- babyfood 0.050 000 1.000 1.000
20003300 20 Safflower, oil 0.050000 1.000 1.000
20003301 20 Safflower, oil

- babyfood 0.050000 1.000 1.000
15003440 15 Sorghum, grain 0.050000 1.000 1.000

15003450 1 5 Sorghum, syrup 0.050000 1.000 1.000
06003470 6 Soybean, seed 0.100000 1.000 1.000
06003480 6 Soybean, flour 0.100000 1.000 1.000Dietary Exposure and Risk Assessment

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### Page 13 of 14 06003481 6 Soybean, flour

- babyfood 0.100000 1.000 1.000
06003490 6 Soybean, soy milk 0.100000 1.000 1.000
06003491 6 Soybean, soy milk

- babyfood or in 0.100000 1.000 1.000
06003500 6 Soybean, oil 0.100000 1.000 1.000
06003501 6 Soybean, oil

- babyfood 0.100000 1.000 1.000
86010000 O Water, direct, all sources 0.001500 1.000 1.000
86020000 O Water, indirect, all sources 0.001500 1.000 1.000
15004010 15 Wheat, grain 0.050000 1.000 1.000
15004011 15 Wheat, grain

- babyfood 0.050000 1.000 1.000
15004020 15 Wheat, flour 0.050000 1.000 1.000
15004021 15 Wheat, flour

- babyfood 0.050000 1.000 1.000
15004030 15 Wheat, germ 0.050000 1.000 1.000
15004040 15 Wheat, bran 0.050000 1.000 1.000

15004050 15 Wild rice 0.050000 1.000 1.000Dietary Exposure and Risk Assessment

Thifensulfuron Methyl PC Code 128 8 4 5 DP Barcode D 399156



### Page 14 of 14 Attachment 5

. Summary of the Chronic Dietary Exposure and Risk Estimates for

Thifensulfuron Methyl.

US Environmental Protection Agency DEEM

- FCID Version 2.03 (1994

- 1996, 1998 data)

DEEM

- FCID Chronic analysis for thifensulfuron methyl
Analysis Date: 2/21/2012 at 14:07:49

Residue file name: ThifensulfuronMethylDEEM 022112 ChronicInput.R98
Residue file date: 2/21/2012 at 14:05:53

Reference dose (Chronic) = 0 .043 mg/kg body weight /day NOAEL (Chronic) = 4.3 mg/kg body weight/day
Run Comment: Adjustment factor #2 NOT used.

Total exposure by population subgroup
Total Exposure Population Subgroup mg/kg bw/day % Rfd U.S. Population (total) 0.000284 0.7%

U.S. Population (spring season) 0.000288 0.7%
U.S. Population (summer season) 0.000288 0.7%
U.S. Population (autumn season) 0.000280 0.7%
U.S. Population (winter season) 0.000281 0.7%

Northeast region 0.000273 0.6%
Midwest region 0.000296 0.7% Southern region 0.000274 0.6%
Western region 0.000298 0.7%

Hispanics 0.000308 0.7%

Non

- hispanic whites 0.000276 0.6%

Non

- hispanic blacks 0.000291 0.7%

Non

- hisp/non

- white/non

- black 0.000335 0.8%

All infants (< 1 year) 0.000487 1.1%
Nursing infants 0.000185 0.4%

Non

- nursing infants 0.000602 1.4%

Children 1

- 6 yrs 0.000602 1.4%

Children 7

- 12 yrs 0.000429 1.0%

Females 13

- 19 (no t preg or nursing) 0.000270 0.6%
Females 20+ (not preg or nursing) 0.000196 0.5%

Females 13

- 50 yrs 0.000239 0.6% Females 13+ (preg/not nursing) 0.00024 4 0.6%
Females 13+ (nursing) 0.000261 0.6%

Males 13

- 19 yrs 0.000348 0.8%
Males 20+ yrs 0.000236 0.5%

Seniors 55 + 0.000171 0.4%

Children 1

- 2 yrs 0.000602 1.4%

Children 3

- 5 yrs 0.000621 1.4%

Children 6

- 12 yrs 0.000447 1.0%

Youth 13

- 19 yrs 0.000310 0.7%

Adults 20

- 49 yrs 0.000239 0.6%
Adults 50+ yrs 0.000175 0.4%

Fem ales 13

- 49 yrs 0.000226 0.5%