Exhibit
10.1


 


Response
to AIM ImmunoTech’s


Request
for Proposal for Trial Services to Support a Phase II Pancreatic Cancer Study


March
30, 2022


 











 


 





 





 









    	 



     


    

 


EXPLANATORY
NOTE: [***] INDICATES THE PORTION OF THIS EXHIBIT


THAT
HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL


AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.


 





 





Important
Information


 


This
proposal for a Project Work Order is provided to AIM ImmunoTech Inc (AIM) for the purpose of its evaluation and the information contained
herein is not intended to be used by (AIM) for any other purpose than the subject of this proposal. (AIM) agrees not to voluntarily disclose
any of the information contained herein to any third party without the prior written consent of Amarex Clinical Research, LLC (Amarex).


 


This
proposal document is subject to negotiation and, when the final version is signed by both parties, shall create a Project Work Order
with legal obligations on the part of both parties.


 


Proposal
Expiration Date: April 8, 2022


 


Prepared
for:


 


AIM
ImmunoTech Inc


2117
SW Highway 484


Ocala,
FL 34473


 





Prepared
by:


 


Amarex
Clinical Research, LLC


20201
Century Boulevard, Suite 450


Germantown,
MD 20874


Phone:
(301) 528-7000


Fax:
(301) 528-2300


 







    	Amarex’s Response to AIM’s Request for Proposal
Amarex Clinical Research, LLC Confidential and Proprietary Information
	3/30/2022
Page i 




     


    

 



EXPLANATORY
                                            NOTE: [***] INDICATES THE PORTION OF THIS EXHIBIT


THAT
HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL


AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.


 





 






Our
Understanding of AIM’s Needs


 


Based
on our discussions with AIM, Amarex understands that AIM plans to conduct a trial entitled: “A Phase 2, Randomized, Open-Label,
Controlled Study to Evaluate the Efficacy and Safety of Ampligen® Compared to Control Group / No Treatment Following FOLFIRINOX in
Subjects with Locally Advanced Pancreatic Adenocarcinoma.” The study will be conducted at up to 30 sites in the United States and
Europe. This proposal covers 20 sites in the US. It is assumed that not all 20 sites will start at once, and that as the course of the
trial goes on, certain sites will be closed out early if they have no active patients left. Discussions around adding European sites
to the project can be addressed in an amendment to this proposal. For the time being, it is assumed one site will be included in the
Netherlands. DSMB meetings have been estimated to occur every 4 months. No interim analysis is planned.


 


Study
Parameters


 


Following
is a list of study parameters Amarex has used in order to prepare this proposal response:


 


Table
1. Study Parameters Used to Prepare This Proposal


 


	STUDY
    PARAMETERS	 	 
	Number
    of US sites	 	[***]
	Number
    of Dutch sites	 	[***]
	Number
    of countries participating in study	 	[***]
	Number
    of subjects randomized/enrolled	 	[***]
	SITE
    MONITORING AND AUDITING	 	 
	Number
    of qualification sites	 	[***]
	Number
    of site initiation visits	 	[***]
	Number
    of interim monitoring sites	 	[***]
	Number
    of closeout visits	 	[***]
	IRB
    MANAGEMENT	 	 
	Number
    of Local IRB to manage	 	[***]
	Number
    of Central IRB to manage	 	[***]
	Number
    of DSMB meetings to review data	 	[***]
	Number
    of statistical tables per DSMB	 	[***]
	Number
    of statistical listings per DSMB	 	[***]



 



    	Amarex’s Response to AIM’s Request for Proposal
Amarex Clinical Research, LLC Confidential and Proprietary Information
	3/30/2022
Page 1




     


    

 



EXPLANATORY
                                            NOTE: [***] INDICATES THE PORTION OF THIS EXHIBIT


THAT
HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL


AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.


 





 



 


	MEDICAL
    MONITORING	 	 
	Estimated
    number of SAEs	 	[***]
	Estimated
    number of reportable events	 	[***]
	DATA
    MANAGEMENT 	 	 
	Estimated
    Number of Adverse Events, Concomitant Medications, and Medical Histories to code	 	[***]
	Number
    of unique pages in eCRF book	 	[***]
	Number
    of central labs & vendors	 	[***]
	BIOSTATISTICS	 	 
	Number
    of stat. tables for final analysis (uniques/replicates)	 	[***]
	Number
    of listings for final analysis (uniques/replicates)	 	[***]
	Number
    of graphs for final analysis (unique/replicate)	 	[***]
	CLINICAL
    STUDY REPORT WRITING	 	 
	Write
    final clinical trial report  	 	[***]
	PROJECT
    MANAGEMENT	 	 
	Number
    of months for project setup	 	[***]
	Number
    of months for enrollment	 	[***]
	Number
    of months for follow-up (treatment period)	 	[***]
	Number
    of months of active study phase for monitoring	 	[***]
	Number
    of months for close out	 	[***]
	Number
    of months of project management (including set up and close out)	 	[***]



 



    	Amarex’s Response to AIM’s Request for Proposal
Amarex Clinical Research, LLC Confidential and Proprietary Information
	3/30/2022
Page 2




     


    

 



EXPLANATORY
                                            NOTE: [***] INDICATES THE PORTION OF THIS EXHIBIT


THAT
HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL


AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.


 





  


Study
Tasks


 


Clearly-defined
roles are essential to project success, and Amarex will work closely with AIM to make sure all project tasks are covered. It is our current
understanding that the tasks associated with this trial are assigned as shown in Table 2, below.


 


Table
2. Study Tasks


 


	Service	 	Not
    Required	 	Amarex	 	AIM
	PROJECT
    MANAGEMENT	 	 	 	 	 	 
	Meetings,
    Training, and Study Start Up	 	 	 	 	 	 
	Prepare
    for and Attend Kick-off Meeting & Study Start-Up	 	 	 	X	 	 
	Prepare
    for and Attend Project Team Training	 	 	 	X	 	 
	Communication
    and Tracking	 	 	 	 	 	 
	Coordinate
    Amarex's Internal Project Team	 	 	 	X	 	 
	Communicate
    with Sponsor (includes standard teleconferences with activities reports, emails, faxes)	 	 	 	X	 	 
	Manage
    Central Labs/Vendors	 	 	 	X	 	 
	Tracking
    Systems Setup	 	 	 	X	 	 
	Management
    of Payments to Sites, IRBs, and/or Vendors	 	 	 	X	 	 
	REGULATORY
    SERVICES	 	X*	 	 	 	 
	PRODUCT
    MANAGEMENT	 	 	 	 	 	 
	Support
    Initial Drug Shipments	 	 	 	X	 	 
	Set
    up of WebView IRTTM product supply tracking and email alert system.  Track drug shipments to sites, drug supply depots,
    auto-email requests for resupply based on randomization.  Require acknowledgement email from drug depot.	 	 	 	X	 	 
	Maintenance
    for WebView IRTTM Resupply and Tracking	 	 	 	X	 	 
	DATA
    MANAGEMENT SERVICES	 	 	 	 	 	 
	Data
    Management	 	 	 	 	 	 
	Develop
    Data Management Plan	 	 	 	X	 	 
	Standard
    Data Cleaning (Run edit checks; generate, process, and track data queries)	 	 	 	X	 	 
	Develop
    Edit Specifications	 	 	 	X	 	 
	Data
    Operations	 	 	 	 	 	 



 



    	Amarex’s Response to AIM’s Request for Proposal
Amarex Clinical Research, LLC Confidential and Proprietary Information
	3/30/2022
Page 3




     


    

 


EXPLANATORY
NOTE: [***] INDICATES THE PORTION OF THIS EXHIBIT


THAT
HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL


AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.


 





  


	Program
    Edit Checks	 	 	 	X	 	 
	Set
    Up Data Transfer from Vendors	 	 	 	X	 	 
	Receive
    and Reconcile Headers of Clean Data from Vendors	 	 	 	X	 	 
	Set
                                            Up Transfer of Final SAS Data to Sponsor

    (In
    Amarex's format)
	 	 	 	X	 	 
	Perform
                                            Data Transfer to Sponsor

    (Including
    export of final SAS Analysis Datasets)
	 	 	 	X	 	 
	EDC
    Support	 	 	 	 	 	 
	Conduct
    Electronic Data Capture Site Training	 	 	 	X	 	 
	Prepare
    EDC Manual and Completion Instructions (includes up to 1 round of edits)	 	 	 	X	 	 
	Prepare
    User Acceptance Testing (UAT) Management Plan	 	 	 	X	 	 
	Conduct
    QC of EDC Database	 	 	 	X	 	 
	Provide
    Electronic Data Capture Help Desk	 	 	 	X	 	 
	WEBVIEW
    EDC PROGRAMMING	 	 	 	 	 	 
	Development
    of CRF Screen Shots	 	 	 	X	 	 
	EDC
    Programming	 	 	 	X	 	 
	EDC
    Maintenance	 	 	 	X	 	 
	CLINICAL
    SITE SERVICES	 	 	 	 	 	 
	Site
    Identification and Contracting	 	 	 	 	 	 
	Prepare
    Site Identification Plan	 	 	 	X	 	 
	Perform
    Site Identification	 	 	 	X	 	 
	Present
    Sites for Site Qualification Visits	 	 	 	X	 	 
	Develop
    Site Contracts (includes up to 2 rounds of edits)	 	 	 	X	 	 
	Negotiate
    Site Contract CTAs	 	 	 	X	 	 
	Negotiate
    Site Contract Budgets	 	 	 	X	 	 
	IRB
    and Ethics Committee Management	 	 	 	 	 	 
	Submit
    and Obtain Initial Approval of Local IRB	 	 	 	X	 	 
	Submit
    and Obtain Initial Approval of Central IRB	 	 	 	X	 	 
	Obtain
    Initial Approval for Sites Affiliated with the Central IRB	 	 	 	X	 	 
	Review
    and Approve IRB Informed Consent Comments	 	 	 	X	 	 
	Review
    and Approve Site Informed Consent Prior to IRB Submission	 	 	 	X	 	 
	Site
    Regulatory Document Collection	 	 	 	 	 	 
	Set
    Up Trial Master File	 	 	 	X	 	 



 



    	Amarex’s Response to AIM’s Request for Proposal
Amarex Clinical Research, LLC Confidential and Proprietary Information
	3/30/2022
Page 4




     


    

 



EXPLANATORY
                                            NOTE: [***] INDICATES THE PORTION OF THIS EXHIBIT


THAT
HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL


AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.


 





  


	Set
    Up, File, and Track Investigator/Site Regulatory Files	 	 	 	X	 	 
	Conduct
    Ongoing Regulatory Document Collection, Review, Tracking, and Maintenance of Trial Master File	 	 	 	X	 	 
	Monitoring
    Services	 	 	 	 	 	 
	Prepare
    Study Operations Manual (includes up to 2 rounds of edits)	 	 	 	X	 	 
	Prepare
    Monitoring Guidelines (includes up to 2 round of edits)	 	 	 	X	 	 
	Perform
    Site Management	 	 	 	X	 	 
	Prepare
    for Site Visit	 	 	 	X	 	 
	Prepare
    Documents for Site Initiation	 	 	 	X	 	 
	Conduct
    Site Qualification Visits	 	 	 	X	 	 
	Conduct
    Study Initiation Visits	 	 	 	X	 	 
	Conduct
    Interim Monitoring Visits	 	 	 	X	 	 
	Conduct
    Close Out Visits	 	 	 	X	 	 
	Travel
    Time for Monitoring Visits	 	 	 	X	 	 
	SAFETY	 	 	 	 	 	 
	Set
    Up Tracking System and SAE Start Up	 	 	 	X	 	 
	Prepare
    Safety Management Plan	 	 	 	X	 	 
	Prepare
    Medical Monitoring Plan	 	 	 	X	 	 
	Set
    Up EDC Safety Reporting Module	 	 	 	X	 	 
	Collect,
    Process, Evaluate SAE or Pregnancy, and Prepare Narrative	 	 	 	X	 	 
	Prepare
    CIOMS or MedWatch Form	 	 	 	X	 	 
	Prepare
    SAE Follow up Reports	 	 	 	X	 	 
	Medical
    Monitoring (24/7)	 	 	 	X	 	 
	Distribute
    SAE "Dear Dr." Letters to Sites	 	 	 	X	 	 
	Submit
    Safety Reports to Regulatory Authorities	 	 	 	X	 	 
	Prepare
    and Submit Full Annual Report for IND (includes TLGs and up to 1 round of edits)	 	 	 	X	 	 
	Set
    Up of Coding System to Code AEs, ConMeds, and Histories	 	 	 	X	 	 
	Prepare
    Medical Coding Plan (includes up to 2 rounds of edits)	 	 	 	X	 	 
	Code
    Adverse Events, Medications, and Histories (Using MedDRA and WHO Drug ATC Level)	 	 	 	X	 	 



 



    	Amarex’s Response to AIM’s Request for Proposal
Amarex Clinical Research, LLC Confidential and Proprietary Information
	3/30/2022
Page 5




     


    

 



EXPLANATORY
                                            NOTE: [***] INDICATES THE PORTION OF THIS EXHIBIT


THAT
HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL


AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.


 





 






	DATA
    SAFETY MONITORING BOARD (DSMB)	 	 	 	 	 	 
	Establish
    and Manage 3-Member DMC	 	 	 	X	 	 
	Develop
    DSMB Charter (includes up to 1 round of edits)	 	 	 	X	 	 
	Organize,
    Conduct and Participate in DSMB Meetings	 	 	 	X	 	 
	Prepare
    Statistical Analysis Plan for DSMB	 	X	 	 	 	 
	Program
    Tables, Listings and Graphs for DSMB	 	 	 	X	 	 
	Prepare
    Statistical Report for DSMB Meetings	 	 	 	X	 	 
	RANDOMIZATION
    AND ENROLLMENT	 	 	 	X	 	 
	Develop
    WebView IRTTM Enrollment/Randomization Module	 	 	 	X	 	 
	Generate
    WebView IRTTM Randomization Code and Plan	 	 	 	X	 	 
	Conduct
    WebView IRTTM Enrollment/Randomization Maintenance	 	 	 	X	 	 
	BIOSTATISTICS	 	 	 	 	 	 
	Prepare
    Statistical Analysis Plan (includes list of TLGs in Amarex standard format, and data set conventions)	 	 	 	X	 	 
	Program
    Tables, Listings and Graphs for Final Analysis	 	 	 	X	 	 
	Conduct
    QC Audit of Stats	 	 	 	X	 	 
	Production
    and Review of Tables, Listings, and Graphs for Final Analysis (per unique display)	 	 	 	X	 	 
	Production
    and Review of Tables, Listings, and Graphs for Final Analysis (per replicate display)	 	 	 	X	 	 
	Base
    ADaM CDISC Conversion (mapping and programming)	 	 	 	X	 	 
	MEDICAL
    WRITING	 	 	 	 	 	 
	Prepare
                                            Interim Clinical Study Report

    (non-ICH
    Format) - includes up to one round of edits
	 	X	 	 	 	 
	Prepare
    Final Clinical Study Report Shell 

    (ICH Format) - includes up to one round of edits	 	 	 	X	 	 
	Prepare
    Subject Narratives for CSR	 	 	 	X	 	 
	Prepare
    Final Clinical Study Report (ICH Format) with Appendices - includes up to two rounds of edits	 	 	 	X	 	 
	Conduct
    QC Audit of Clinical Study Report	 	 	 	X	 	 


 


X*
- Regulatory work is covered under a separate agreement.


 




    	Amarex’s Response to AIM’s Request for Proposal
Amarex Clinical Research, LLC Confidential and Proprietary Information
	3/30/2022
Page 6




     


    

 


EXPLANATORY
NOTE: [***] INDICATES THE PORTION OF THIS EXHIBIT


THAT
HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL


AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.


 





 



Proposed
Amarex Direct Services Budget


(US
Dollars)


US


 


	AMAREX
    DIRECT SERVICES FEES	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	Bid
    ID	 	Service	 	Unit
    Description	 	Unit
    Cost $	 	 	No.
    
 Units	 	 	Total
    
 Cost $	 	 	Category
    
 Total $	 
	B	 	PROJECT
    MANAGEMENT	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	Meetings,
    Training, and Study Start Up	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	11	 	Prepare
    for and Attend Kick-off Meeting & Study Start-Up	 	per protocol	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	16	 	Prepare
    for and Attend Project Team Training	 	per day	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	 	 	Communication
    and Tracking	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	17	 	Coordinate
    Amarex's Internal Project Team	 	per month	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	18	 	Communicate
    with Sponsor (includes standard teleconferences with activities reports and emails)	 	per month	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	19	 	Manage
    Central Labs/Vendors	 	per lab-vendor/per
    month	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	20	 	Tracking
    Systems Setup	 	fixed
    fee	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	27.1	 	Management
    of Payments to Sites, IRBs, Labs, and/or Vendors	 	per
    payment / site, IRB or vendor	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 
	D	 	PRODUCT
    MANAGEMENT	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	59	 	Set
    up of WebView IRT product supply tracking and email alert system.  Track drug shipments to sites, supply depots, auto-email
    requests for resupply based on randomization.  Require acknowledgement email from supply depot.	 	per project	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	60	 	Maintenance
    for WebView IRT Product Resupply and Tracking	 	per site per month	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	63	 	Support
    Initial Drug Shipments	 	per site per shipment	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 
	E	 	DATA
    MANAGEMENT SERVICES	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	Data
    Management	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	65	 	Develop
    Data Management Plan	 	per project	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	73	 	Standard
    Data Cleaning (Run edit checks; generate, process, and track data queries)	 	per query	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	78	 	Develop
    Edit Specifications	 	per project	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	 	 	Data
    Operations	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	86	 	Program
    Edit Checks	 	per edit check	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	88	 	Set
    Up Data Transfer from Vendors	 	fixed
    cost/per vendor	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	89	 	Receive
    and Reconcile Headers of Clean Data from Vendors	 	per transfer/per
    vendor	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	91	 	Set
    Up Transfer of Final SAS Data to Sponsor (in Amarex's format)	 	per dataset	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	92	 	Perform
    Data Transfer to Sponsor 
 (Including export of final SAS Analysis Datasets)	 	per transfer	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	 	 	EDC
    Support	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	95	 	Conduct
    Electronic Data Capture Site Training	 	per training	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	96	 	Prepare
    EDC Manual and Completion Instructions (includes up to 1 round of edits)	 	per manual	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	97	 	Prepare
    User Acceptance Testing (UAT) Management Plan	 	per document	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	98	 	Conduct
    QC of EDC Database	 	per subject enrolled	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	99	 	Provide
    Electronic Data Capture Help Desk	 	per month	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 
	 	 	WEBVIEW
    EDC PROGRAMMING	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	101	 	Development
    of CRF Screen Shots	 	per unique page	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	102	 	WebView
    EDC Programming (Initiation)	 	per study	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	103	 	WebView
    EDC Programming (UAT 1)	 	per study	 	$	[***]	 	 	 	[***]	 	 	$	 [***]	 	 	 	 

                                                                           

                                                                           
	 
	104	 	WebView
    EDC Programming (System Activation)	 	per
    study	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	105	 	WebView
    EDC Maintenance	 	per
    month	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 



 






    	Amarex’s Response to AIM’s Request for Proposal
Amarex Clinical Research, LLC Confidential and Proprietary Information
	3/30/2022
Page 7




     


    

  



EXPLANATORY
                                            NOTE: [***] INDICATES THE PORTION OF THIS EXHIBIT


THAT
HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL


AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.


 









 





	AMAREX
    DIRECT SERVICES FEES	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	Bid
    ID	 	Service	 	Unit
    Description	 	Unit
    Cost $	 	 	No.
    
 Units	 	 	Total
    
 Cost $	 	 	Category
    
 Total $	 
	F	 	CLINICAL
    SITE SERVICES	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	Site
    Identification and Contracting	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	106	 	Prepare
    Site Identification Plan	 	per
    plan	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	107	 	Perform
    Site Identification and Present Sites for Site Qualification Visits	 	per
    site recommended	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	108	 	Develop
    Site Contracts (includes up to 2 rounds of edits)	 	per
    contract	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	109	 	Negotiate
    Site Contract CTAs	 	per
    site	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	110	 	Negotiate
    Site Contract Budgets	 	per
    site	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	 	 	IRB
    and Ethics Committee Management	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	112	 	Submit
    and Obtain Initial Approval of Local IRB	 	per
    submission per Local IRB	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	113	 	Submit
    and Obtain Initial Approval of Central IRB	 	per
    submission per Central IRB	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	114	 	Obtain
    Initial Approval for Sites Affiliated with the Central IRB	 	per
    submission per site	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	116	 	Review
    and Approve IRB Informed Consent Comments	 	per
    IRB	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	117	 	Review
    and Approve Site Informed Consent Prior to IRB Submission	 	per
    site	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	Site
    Regulatory Document Collection	 	 	 	 	 	 	 	 	 	 	 	$	[***]	 	 	 	 	 
	120	 	Set
    Up Florence Trial Master File	 	per
    study	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	121	 	Set
    Up Investigator/Site Regulatory Files	 	per
    site	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	122	 	Conduct
    Ongoing Regulatory Document Collection, Review, and Maintenance of eTMF	 	per
    site/per month	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	 	 	Monitoring
    Services	 	 	 		 	 	 	 	 	 	 	 	 	 	 	 	 	 
	123	 	Prepare
    Study Operations Manual (includes up to 2 rounds of edits)	 	per
    project	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	124	 	Prepare
    Monitoring Guidelines (includes up to 2 round of edits)	 	per
    project	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	125	 	Perform
    Site Management	 	per
    site/per month	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	127	 	Prepare
    Documents for Site Initiation	 	per
    project	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	128	 	Conduct
    Site Qualification Visits (includes prep and visit report in Amarex format)	 	per
    one-day visit	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	129	 	Conduct
    Study Initiation Visits (includes prep and visit report in Amarex format)	 	per
    one-day visit	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	130	 	Conduct
    Interim Monitoring Visits (includes prep and visit report in Amarex format)	 	per
    one-day visit	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	131	 	Conduct
    Close Out Visits (includes prep and visit report in Amarex format)	 	per
    one-day visit	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	133	 	Travel
    Time for Monitoring Visits	 	per
    trip	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 
	G	 	SAFETY	 	 	 		 	 	 	 	 	 	 		 	 	 	 	 	 
	143	 	SAE
    Start Up	 	fixed
    fee	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	144	 	Prepare
    Safety Management Plan (includes up to 1 round of edits)	 	per
    plan	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	145	 	Prepare
    Medical Monitoring Plan (includes up to 1 round of edits)	 	per
    plan	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	146	 	Set
    Up WebView EDC Safety Reporting Module	 	per
    project	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	148	 	Collect,
    Process, Evaluate SAE/UADE or Pregnancy, and Prepare Narrative	 	per
    event	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	149	 	Prepare
    CIOMS or MedWatch Form	 	per
    reportable event	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	150	 	Prepare
    SAE/UADE Follow up Reports	 	per
    update	 	$	[***]	 	 	 	[***]	 	 	 	[***]	 	 	 	 	 
	152	 	Medical
    Monitoring Support Line (24/7)	 	per
    month	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	154	 	Distribute
    SAE/UADE "Dear Dr." Letters to Sites	 	per
    letter per site	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	155	 	Submit
    Safety Reports to Regulatory Authorities	 	per
    reportable event per country	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 



 







    	Amarex’s Response to AIM’s Request for Proposal
Amarex Clinical Research, LLC Confidential and Proprietary Information
	3/30/2022
Page 8




     


    

 



EXPLANATORY
                                            NOTE: [***] INDICATES THE PORTION OF THIS EXHIBIT


THAT
HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL


AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.


 





 






 



	156	 	Prepare
    and Submit Full Annual Report for IDE/IND (includes TLGs and up to 1 round of edits)	 	per
    submission	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	159	 	Set
    Up of Coding System to Code AEs, ConMeds, and Histories	 	fixed
    cost	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	160	 	Prepare
    Medical Coding Plan (includes up to 2 rounds of edits)	 	per
    plan	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	161	 	Code
    Adverse Events, Medications, and Histories (Using MedDRA and WHO Drug ATC Level)	 	per
    term	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 






	AMAREX
    DIRECT SERVICES FEES	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	Bid
    ID	 	Service	 	Unit
    Description	 	Unit
    Cost $	 	 	No.
    
 Units	 	 	Total
    
 Cost $	 	 	Category
    
 Total $	 
	H	 	DATA
    SAFETY MONITORING BOARD (DSMB)	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	163	 	Establish
    and Manage 3-Member DSMB	 	fixed
    cost	 	$	[***]	 	 	 	[***]	 	 	$	
                                            [***]	 	 	 	 	 
	164	 	Develop
    DSMB Charter (includes up to 1 round of edits)	 	per
    project	 	$	[***]	 	 	 	[***]	 	 	$	
                                            [***]	 	 	 	 	 
	165	 	Organize,
    Conduct and Participate in DSMB Meetings	 	per
    meeting	 	$	[***]	 	 	 	[***]	 	 	$	
                                            [***]	 	 	 	 	 
	167	 	Program
    and Produce Unique Tables for DSMB	 	per
    unique table	 	$	[***]	 	 	 	[***]	 	 	$	
                                            [***]	 	 	 	 	 
	168	 	Program
    and Produce Replicate Tables for DSMB	 	per
    replicate table	 	$	[***]	 	 	 	[***]	 	 	$	
                                            [***]	 	 	 	 	 
	169	 	Program
    and Produce Unique Listings for DSMB	 	per
    unique listing	 	$	[***]	 	 	 	[***]	 	 	$	
                                            [***]	 	 	 	 	 
	170	 	Program
    and Produce Replicate Listings for DSMB	 	per
    replicate listing	 	$	[***]	 	 	 	[***]	 	 	$	
                                            [***]	 	 	 	 	 
	172	 	Prepare
    Statistical Report for DSMB Meeting (open and closed session reports, includes up to 1 round of edits)	 	per
    meeting	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 
	I	 	RANDOMIZATION
    AND ENROLLMENT	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	176	 	Develop
    WebView IRT Enrollment/Randomization Module	 	per
    project	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	177	 	Generate
    WebView IRT Randomization Code and Plan	 	per
    project	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	178	 	Conduct
    WebView IRT Enrollment/Randomization Maintenance	 	per
    month	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 
	J	 	BIOSTATISTICS	 	 	 		 	 	 	 	 	 	 	 	 	 	 	 	 	 
	182	 	Prepare
    Statistical Analysis Plan (includes list of TLGs in Amarex standard format, and data set conventions)	 	per
    project	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	189	 	Program
    Tables for Final Analysis (unique tables)	 	per
    unique table	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	190	 	Program
    Tables for Final Analysis (replicate tables)	 	per
    replicate table	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	191	 	Program
    Listings for Final Analysis (unique listings)	 	per
    unique listing	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	192	 	Program
    Listings for Final Analysis (replicate listings)	 	per
    replicate listing	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	193	 	Program
    Graphs for Final Analysis (unique graph)	 	per
    unique graph	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	195	 	Conduct
    QC Audit of Stats	 	per
    lock	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	198	 	Production
    and Review of Tables, Listings, and Graphs for Final Analysis (per unique display)	 	per
    unique display	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	199	 	Production
    and Review of Tables, Listings, and Graphs for Final Analysis (per replicate display)	 	per
    replicate display	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	 	 	Other	 	 	 	 	 	 	 	 	 	 	 		 	 	 	 	 	 
	202	 	Base
    ADaM CDISC Conversion (mapping and programming)	 	per
    conversion	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	$
                                            [***]	 
	K	 	MEDICAL
    WRITING	 	 	 		 	 	 	 	 	 	 	 	 	 	 	 	 	 
	211	 	Prepare
    Final Clinical Study Report Shell (ICH Format) - includes up to one round of edits	 	per
    report	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	212	 	Prepare
    Subject Narratives for CSR	 	per
    narrative	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	213	 	Prepare
    Final Clinical Study Report (ICH Format) with Appendices - includes up to two rounds of edits	 	per
    report	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	214	 	Conduct
    QC Audit of Clinical Study Report	 	per
    report	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 
	M	 	GENERAL
    & ADMINISTRATIVE EXPENSES	 	 	 		 	 	 	 	 	 	 	 	 	 	 	 	 	 
	221	 	G&A
    Expenses	 	per
    month	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 
	N	 	ADDITIONAL
    SERVICES	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	253	 	Identify,
    Contract, and Setup Vendor	 	per
    vendor	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	Executive
    Discount ([***]%)	 	 	 	 	 	 	 	 	 	 	 	$	 
                                            ([***]])	 	 	 	 	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	TOTAL
    OF ACTIVITY-BASED COSTING	 	 	 	 	 	 	 	 	 	 	 	$	[***]
                                            
  
	 	 	 	 	 



  



    	Amarex’s Response to AIM’s Request for Proposal
Amarex Clinical Research, LLC Confidential and Proprietary Information
	3/30/2022
Page 9




     


    



EXPLANATORY
                                            NOTE: [***] INDICATES THE PORTION OF THIS EXHIBIT


THAT
HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL


AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.


 







 













Netherlands


 






 


	CLINICAL
    SITE SERVICES
	Bid
    ID	 	Service	 	Unit
    Description	 	 	 Unit
                                            Cost $ 	 	 	 	No.
                                            Units	 	 	 	 Total
                                            Cost $ 	 	 	 	 Category
                                            Total $ 	 
	 	 	Study
start-up (1 months)	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	1	 	Study
familiarisation	 	Once	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	2	 	Study
KO meeting (TC)	 	Once	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	3	 	Preparation
    of PM Plans	 	Plans	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	4	 	Site
initiation	 	Sites	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	5	 	In-house
SCRA activities - set up including site communication	 	Site / months	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	6	 	Sponsor
TCs - set up	 	Alternate
Weeks	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	 
                                            [***]	 
	 	 	Conduct
(5 months)	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	7	 	Monitoring
    Visits	 	IMV	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	8	 	In-house
SCRA activities - conduct including site communication	 	Site / months	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	9	 	Sponsor
TCs - Conduct	 	monthly	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	 
                                            [***]	 
	 	 	Study
closure (1 months)	 	 	 		 	 	 	 	 	 	 	 	 	 	 	 	 	 
	10	 	Close-Out	 	 COVs	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	11	 	In-house
SCRA activities - closure including site communication	 	Site / months	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	12	 	Sponsor
TCs - closure	 	Alternate
    Weeks	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	TOTAL	 		 	 		 	 	 		 	 	$	 
                                            [***] 		 	 		 



 


	OPTIONAL
    SERVICES
	Bid
    ID	 	Service	 	Unit
    Description	 	 	Unit
                                            Cost $ 	 	 	 	No.
                                            
 Units	 	 	 	Total
                                            
 Cost $ 	 	 	 	Category
                                            
 Total $ 	 
	 	 	Study
    start-up (1 months)	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	13	 	Backup
    CRA familiarization and training	 	per CRA	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	14	 	Set
    up shadow TMF	 	Sites	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	15	 	Set
    up ISFs	 	Sites	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 
	 	 	Conduct(5
    months)	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	16	 	Maintenance
    of TMF - Conduct	 	Site / months	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 
	 	 	Study
    closure (1 months)	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	17	 	Return
    of TMF to sponsor	 	Sites	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 
	 	 	Ad
    Hoc	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	18	 	Ad
    hoc project support	 	per hour	 	$	[***]
                                            	 	 	 	TBD	 	 	 	 TBD
                                            	 	 	 	 TBD
                                            	 



 


The
unit costs provided in the budget are discounted according to certain economies of scale. A reduction of tasks or units could result
in higher unit costs for remaining tasks or units.


 




    	Amarex’s Response to AIM’s Request for Proposal
Amarex Clinical Research, LLC Confidential and Proprietary Information
	3/30/2022
Page 10




     


    

 



EXPLANATORY
                                            NOTE: [***] INDICATES THE PORTION OF THIS EXHIBIT


THAT
HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL


AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.


 








 


Additional
units in excess of those planned above will be billed at the same unit rate as shown above.


 


Amarex
budgets services by ‘tasks’ as opposed to by hours. Each task has a fixed unit price associated with it and an estimated
number of units proposed for the project. Please examine the estimated number of units for each task carefully to make sure they agree
with your expectation. Amarex reserves the right to increase its rates on an annual basis. This increase will not exceed 5% per year.





 


Estimated
Pass-Through Costs


 






 


	ESTIMATED
                                            PASS THROUGH COSTS






	Bid
    ID	 	Expense	 	Unit
    Description	 	 	Unit
                                            
 Cost $	 	 	 	No.
                                            
 Units	 	 	 	Total
                                            
 Cost $ 	 	 	 	Category
                                            
 Total $ 	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	A	 	TRAVEL
    AND MEETINGS	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	US
    Monitoring Visit Costs (Travel and Living)	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	1	 	Airfare	 	per flight	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	2	 	Ground
    Transportation	 	per day	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	3	 	Parking	 	per trip	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	4	 	Hotel
    Accommodations	 	per night	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	5	 	Meals	 	per day	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 
	B	 	PRINTING
    & ASSEMBLY OF STUDY MATERIALS	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	36	 	Miscellaneous
    Printing/Copying	 	per site per month	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 
	C	 	SHIPPING
    COSTS (CRFs, Study Binders, etc.)	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	39	 	Overnight
    delivery (UPS/FedEx)	 	per site per month	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 
	E	 	MISCELLANEOUS	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	48	 	DSMB
    Honorarium	 	per person per meeting	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	51	 	Ad
    Hoc Electronic Data Transfers Over 12MB	 	per transfer	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	53	 	Florence
    eTMF Annual Study Fee	 	per study per year	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	 	 	 
	54	 	Florence
    eTMF Annual Entity User Fee	 	per entity per year	 	$	[***]	 	 	 	[***]	 	 	$	[***]	 	 	$	[***]	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	TOTAL
                                            OF ESTIMATED PASS THROUGHS
 
	 	 	 	 	 	 	 	 	 	 	 	$	1,027,000.00	 	 	 	 	 



 


Pass-through
expenses, such as: approved travel, document shipping and printing, and other project related out-of-pocket expenses incurred by Amarex
in the conduct of the study will be invoiced to AIM at the actual cost. These expenses will be supported by acceptable documentation
or actual receipts.


 




    	Amarex’s Response to AIM’s Request for Proposal
Amarex Clinical Research, LLC Confidential and Proprietary Information
	3/30/2022
Page 11




     


    





 



EXPLANATORY
                                            NOTE: [***] INDICATES THE PORTION OF THIS EXHIBIT


THAT
HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL


AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.


 






 


Third
Party Costs


 






 


Third
party costs are not included in this proposal. They can be further discussed with AIM.


 







    	Amarex’s Response to AIM’s Request for Proposal
Amarex Clinical Research, LLC Confidential and Proprietary Information
	3/30/2022
Page 12




     


    

 






EXPLANATORY
                                            NOTE: [***] INDICATES THE PORTION OF THIS EXHIBIT


THAT
HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL


AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.


 








 


Payment
Schedule and Terms


Payment
Schedule for Services


 






 


The
payment terms and obligations for the services outlined in this proposal are as follows:


 


	Payment
    Description	 	Percentage
    Due	 	 	Amount	 
	Execution
    of Project Work Order	 	 	[***]	% 	 	$	[***]	 
	Monthly
    Unit-Based Billing	 	 	Balance
                                            Due	 	 	$	[***]	 
	TOTAL	 	 	 	 	 	$	7,186,493.11	 



 


Optional
services will be billed on a monthly basis, as needed.


 


The
Execution fee will be credited back as follows: $[***] will be credited when the total service invoicing reaches each of the following
amounts $[***], $[***], and $[***].


 


Payment
Schedule for Pass-Through Expenses


 






 


Pass-through
expenses such as approved travel, document shipping and printing, and other reasonable expenses will be invoiced to AIM at cost. These
expenses will be supported by acceptable documentation or actual receipts and will be invoiced on a monthly basis.


Payment
Terms


 






		■	Payments
                                            are due 30 days after delivery of an invoice.



		■	Late
                                            payment fee: 1% per month interest on all past due, unpaid balances.



		■	Amarex
                                            Clinical Research, LLC Tax ID: [***]



		■	Please
                                            include Invoice numbers on all payments



		■	Payments
                                            will be sent to Amarex’s partner company NSF International



		■	Payments
                                            will be wire transferred to the NSF International bank account at:



JP
Morgan Chase


New
York, NY, USA


Acct.
No.: [***]


ABA
No.:  021000021


SWIFT
Code: CHASUS33


 







    	Amarex’s Response to AIM’s Request for Proposal
Amarex Clinical Research, LLC Confidential and Proprietary Information
	3/30/2022
Page 13




     


    

 






EXPLANATORY
                                            NOTE: [***] INDICATES THE PORTION OF THIS EXHIBIT


THAT
HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL


AND
(II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.


 








 


Project
Work Order Signatures


 


In
Witness Whereof, AIM ImmunoTech Inc. and Amarex Clinical Research, LLC agree to all items and payment terms and conditions presented
in this Project Work Order as indicated by the signatures below of their respective duly authorized representatives as of the “Effective
Date”, appearing below.


 


ACKNOWLEDGED,
ACCEPTED, AND AGREED TO:


 


	For
    and on behalf of AIM ImmunoTech Inc.:	 	For
    and on behalf of Amarex Clinical Research, LLC:
	 	 	 
	Print
    Name:	Peter
    W. Rodino, III	 	Print
    Name:	Kazem
    Kazempour
	Signature:	/s/
    Peter W. Rodino	 	Signature:	/s/
    Kazem Kazempour
	Title:	COO
    & General Counsel	 	Title:	President
    and CEO (Member)
	Effective
    Date:	April
    7, 2022	 	Effective
    Date:	April
    7, 2022



 






    	Amarex’s Response to AIM’s Request for Proposal
Amarex Clinical Research, LLC Confidential and Proprietary Information
	3/30/2022
Page 14