Dietary Exposure and Risk Assessment

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departure (POD), such as the NOAEL or LOAEL, divided by the requisite uncertainty and/or 

safety factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in 

more detail are available on the EPA pesticides web site, Available Information on Assessing 

Exposure from Pesticides, A User’s Guide (21 June 2000), which can be accessed via the web 

link http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf (or see SOP 99.6, 

dated 20 August 1999). 

The most recent dietary risk assessment for thifensulfuron methyl was conducted by W.T. Drew 

(D369038; 19 January 2010). That assessment appended the previous assessment to include 

residue estimates in safflower, supporting the establishment of a permanent tolerance for 

thifensulfuron methyl in the raw agricultural commodity (RAC), safflower seeds. This current 

document includes residue estimates in chicory roots and tops (leaves), supporting the requested 

Section 3 registration of thifensulfuron methyl for use on chicory. 

2. Residue Information

The Interregional Research Project Number 4 (IR-4), has submitted a tolerance petition, 1E7885, 

proposing the establishment of tolerances for residues of the herbicide, thifensulfuron methyl, in 

or on chicory roots and tops (the RACs) at 0.01 ppm. Permanent tolerances have been 

established for thifensulfuron methyl (40CFR §180.439[a]) in cereal grains (barley, field corn, 

oat, rice, sorghum, triticale and wheat), canola, cotton, flax and soybeans. A regional tolerance

has been established (40CFR §180.439[c]) in safflower seeds. A listing of the current tolerances 

for residues of thifensulfuron methyl in the various commodities is appended to this document as 

Attachment 1 (Table 6). The ROC, for both tolerance enforcement and risk assessment, is the 

parent compound, thifensulfuron methyl. Both the acute and chronic assessments are highly 

conservative, and assume 100%CT, along with tolerance-level residues for all agricultural 

commodities. The default processing factor from DEEM 7.81 was used for corn syrup in the 

analyses. 

The lowest limit of method validation (LLMV) was 0.01 ppm in chicory roots and tops (leaves). 

Thifensulfuron methyl residues were <LLMV in all samples from both the 1X and 5X field 

trials. There are no animal feedstuffs associated with the use on chicory. 

3. Drinking Water Data

The thifensulfuron methyl drinking water residues used in these dietary risk assessments were

provided in Drinking Water Assessments (DWAs) by the Environmental Fate and Effects 

Division (EFED), and incorporated directly into the dietary assessments. Water residues were 

incorporated in DEEM-FCIDTM via entry into the food categories “water, direct, all sources” and 

“water, indirect, all sources.” 
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The highest estimated drinking water concentration (EDWC) for acute scenarios was in surface 

water, at 0.0044 ppm. This concentration was derived via utilization of the FQPA Index 

Reservoir Screening Tool (FIRST) model (D391089; W.J. Shaughnessy; 12 January 2012). The 

highest EDWC for chronic scenarios was also in surface water, at 0.0015 ppm. This 

concentration was also obtained by utilizing the FIRST model (D332797; J. Breithaupt; 26 

October 2006). 

In order to be more conservative, the highest of the acute, and the highest of the chronic EDWCs 

(among all the various acute and chronic scenarios modeled) were taken from EFED’s two 

DWAs. The acute and chronic EDWCs used in the respective dietary analyses are shown in 

bold type in Tables 1 and 2 (below), respectively, along with the other scenarios assessed by 

EFED. 

TABLE 1 Maximum EDWCs for Drinking Water Risk Assessment, Based upon Ground Application 

of Thifensulfuron Methyl.* 

Drinking Water Source 

[Model Used]

Use [Rate Modeled] Scenario Maximum EDWC 

(ppb)

Groundwater [SCIGROW] Safflower [0.0188 lbs ai/A] Acute and Chronic 0.0326

Barley, fallow [0.056 lbs ai/A] Acute and Chronic 0.0972

Surface water [FIRST] Safflower [0.0188 lbs ai/A] Acute 1.656

Chronic 0.336

Barley, fallow [0.056 lbs ai/A] Acute 4.429

Chronic 0.900

* D391089; W.J. Shaughnessy; 12 January 2012. 

TABLE 2 Maximum EDWCs for Drinking Water Risk Assessment, Based upon Aerial Application 

of Thifensulfuron Methyl.* 

Drinking Water Source 

[Model Used]

Use [Rate Modeled] Scenario Maximum EDWC 

(ppb)

Surface water [FIRST] Soybean [0.032 lbs ai/A] Acute 3.9

Chronic 1.5

* D332797; James Breithaupt; 26 October 2006. 

The various models used by EFED in conducting DWAs, and their descriptions, are available at 

the EPA website via the web link, http://www.epa.gov/oppefed1/models/water/. No surface or 

ground water monitoring data were available for thifensulfuron methyl. 

4. DEEM-FCIDTM Program and Consumption Information

Thifensulfuron methyl acute and chronic dietary exposure assessments were conducted using 

DEEM-FCIDTM (Version 2.03), which incorporates consumption data from USDA’s CSFII, 

1994 to 1996, and 1998. The 1994-96, 1998 data are based on the reported consumption of more 

than 20,000 individuals over two non-consecutive survey days. Foods “as consumed” (such as 

apple pie) are linked to EPA-defined food commodities (such as apples, peeled fruit - cooked, 
Dietary Exposure and Risk Assessment

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fresh/unspecified, or baked; or wheat flour - cooked, fresh/unspecified, or baked) using publicly 

available recipe translation files developed jointly by USDA/ARS and EPA. For chronic 

exposure assessment, consumption data are averaged for the entire US population, and within 

population subgroups, but for acute exposure assessment, they are retained as individual 

consumption events (which is why it is appropriate to add residue values together for the acute 

assessment, while separate exposure estimates are summed for the chronic assessment). Based 

on analysis of the 1994-96, 1998 CSFII consumption data, which took into account dietary 

patterns and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general US population, all infants (<1 year old), children 1-

2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years 

old. 

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (such as orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form. The resulting residue consumption 

estimate for each food/food form is summed with the residue consumption estimates for all other 

food/food forms on the commodity residue list to arrive at the total average estimated exposure. 

Exposure is expressed in mg/kg body weight/day, and as a percent of the cPAD. This procedure 

is performed for each population subgroup. 

For acute exposure assessments, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate, and summed to obtain a total daily pesticide exposure for 

a deterministic exposure assessment, or “matched” in multiple random pairings with residue 

values, and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (those who reported eating relevant 

commodities/food forms) and a per-capita (those who reported eating the relevant commodities 

as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk 

are reported for all levels of refinement of the analysis. However, for analyses which are largely 

unrefined, significant differences in user versus per capita exposure and risk are identified, and 

noted in the risk assessment. 

5. Toxicological Information

For detailed information, please refer to the human health risk assessment conducted for 

thifensulfuron methyl use on chicory (D391088; W.T. Drew; 1 June 2012). The database 

adequately characterizes thifensulfuron methyl as having low (Category III or IV) acute oral, 

dermal and inhalation toxicity. The data show moderate eye irritation (Category III), and slight 

dermal irritation (Category IV). Thifensulfuron methyl is not a dermal sensitizer. 

The risk assessment team evaluated the toxicology database for thifensulfuron methyl, and 

selected doses and endpoints for acute and chronic dietary exposure risk assessments. The acute 

and chronic dietary reference doses and PADs are summarized in Table 3 (below). The risk 
Dietary Exposure and Risk Assessment

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assessment team also evaluated the potential for increased susceptibility of infants and children 

from exposure to thifensulfuron methyl. The team concluded that the FQPA Safety Factor 

should be reduced to 1X, as there are no residual uncertainties for pre- or post-natal toxicity. 

Thifensulfuron methyl was classified as not likely to be a human carcinogen, based on the lack 

of evidence of carcinogenicity in both the rat and the mouse. Therefore, cancer dietary risk is 

not of concern. 

TABLE 3 Summary of Thifensulfuron Methyl Toxicological Doses and Endpoints for Use in Dietary 

Exposure and Risk Assessments. 

Exposure/

Scenario

Point of 

Departure

Uncertainty/FQPA 

Safety Factors

LOC for Risk 

Assessment

Study and Toxicological Effects

Acute dietary

(females 13-49 

only)

NOAEL = 

159

mg/kg/day

UFA = 10X

UFH = 10X

FQPA SF = 1

aRfD = 1.59 

mg/kg/day

aPAD = 1.59 

mg/kg/day

Developmental oral toxicity in rats. 

LOAEL = 725 mg/kg/day, based on 

decreased mean body weight, and 

increased incidence of small renal 

papillae. 

Chronic dietary

(all populations)

NOAEL = 

4.3

mg/kg/day

UFA = 10X

UFH = 10X

FQPA SF = 1

cRfD = 0.043 

mg/kg/day

cPAD = 0.043 

mg/kg/day

Carcinogenicity oral toxicity in mice. 

LOAEL = 128 mg/kg/day, based on 

decreased body weight and body 

weight gain. 

Cancer (oral) Not likely to be a human carcinogen, based on the lack of evidence of carcinogenicity in rats 

and mice.

Point of Departure (POD) = a data point or estimated point derived from observed dose-response data, which is used 

to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. UF = Uncertainty Factor. UFA = extrapolation from animal to human (interspecies). UFH = potential 

variation in sensitivity among members of the human population (intraspecies). UFDB = database uncertainty factor

to account for the absence of key data (such as the lack of a critical study). FQPA SF = FQPA Safety Factor. 

NOAEL = No Observed Adverse Effect Level. LOAEL = Lowest Observed Adverse Effect Level. PAD = 

Population Adjusted Dose (a = acute, c = chronic). RfD = Reference Dose. MOE = Margin Of Exposure. LOC = 

Level Of Concern. 

6. Results/Discussion

As previously stated, for acute and chronic assessments, HED is concerned when dietary risk 

exceeds 100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the 

US population, and various population subgroups. The results of the acute analysis are 

summarized in Table 4 (below) for females 13-49 years of age, the only subgroup for which an 

acute dietary endpoint was identified. As shown in Table 4, the risk estimate associated with 

acute dietary exposure to thifensulfuron methyl is below HED’s LOC. The acute dietary risk 

estimate at the 95th percentile of exposure is less than 1% of the aPAD for females 13-49. 
Dietary Exposure and Risk Assessment

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TABLE 4 Summary of Acute Dietary Exposure and Risk Estimates for Thifensulfuron Methyl. 

Population Subgroup

[Years of Age]

DEEM Acute Dietary Analysis (95th Percentile)

aPAD (mg/kg/day) Exposure Estimate 

(mg/kg/day)

% aPAD

General US Population NA* NA NA

All Infants [< 1]

Children [1-2]

Children [3-5]

Children [6-12]

Youths [13-19]

Adults [20-49]

Adults [50+]

Females [13-49] 1.59 0.000544 <1

* NA = Not Applicable. 

The results of the chronic analysis are summarized in Table 5 (below) for the general US 

population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

females 13-49, adults 20-49, and adults 50+ years. Chronic dietary risk estimates are less than or 

equal to 1.4% of the cPAD for all population subgroups, as shown in Table 5. Children 3 to 5

years of age are the most highly-exposed subgroup. 

TABLE 5 Summary of Chronic Dietary Exposure and Risk Estimates for Thifensulfuron Methyl. 

Population Subgroup*

[Years of Age]

DEEM Chronic Dietary Analysis

cPAD (mg/kg/day) Exposure Estimate

(mg/kg/day)

% cPAD

General US Population 0.043 0.000284 <1

All Infants [<1] 0.000487 1.1

Children [1-2] 0.000602 1.4

Children [3-5] 0.000621 1.4

Children [6-12] 0.000447 1.0

Youth [13-19] 0.000310 <1

Adults [20-49] 0.000239 <1

Adults [50+] 0.000175 <1

Females [13-49] 0.000226 <1

* Values for the population subgroup with the highest risk are in bold type. 

All acute and chronic dietary risk estimates are below HED’s LOC. 

7. Characterization of Inputs/Outputs

This assessment is based on tolerance-level residues in all agricultural commodities, and assumes 

that all crops with existing or proposed tolerances are treated (100%CT). These assumptions 

result in highly conservative, health-protective estimates of dietary exposure and risk. 
Dietary Exposure and Risk Assessment

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8. Conclusions

There are no dietary exposure considerations that would preclude the establishment of permanent

tolerances for residues of thifensulfuron methyl in/on chicory roots and tops (leaves). 

9. List of Attachments

Attachment 1. Established Tolerances for Residues of Thifensulfuron Methyl. 

Attachment 2. Thifensulfuron Methyl Residues Used for Acute Dietary Exposure Estimates. 

Attachment 3. Summary of the Acute Dietary Exposure and Risk Estimates for Thifensulfuron 

Methyl. 

Attachment 4. Thifensulfuron Methyl Residues Used for Chronic Dietary Exposure Estimates. 

Attachment 5. Summary of the Chronic Dietary Exposure and Risk Estimates for Thifensulfuron

Methyl. 
Dietary Exposure and Risk Assessment

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Attachment 1. Established Tolerances for Residues of Thifensulfuron Methyl. 

TABLE 6 Established Tolerances for Residues of 

Thifensulfuron Methyl. 

Commodity Parts Per Million

Barley, grain 0.05

Barley, hay 0.8

Barley, straw 0.10

Canola, seed 0.02

Corn, field, forage 0.10

Corn, field, grain 0.05

Corn, field, stover 0.10

Cotton, gin byproducts 0.02

Cotton, undelinted seed 0.02

Flax, seed 0.02

Oat, forage 0.2

Oat, grain 0.05

Oat, hay 0.05

Oat, straw 0.10

Rice, grain 0.05

Rice, straw 0.05

Sorghum, grain, forage. 0.05

Sorghum, grain, grain 0.05

Sorghum, grain, stover 0.05

Soybean 0.10

Wheat, forage 2.5

Wheat, grain 0.05

Wheat, hay 0.7

Wheat, straw 0.10

Safflower, seed* 0.05

* Regional registration. 

Attachment 2. Thifensulfuron Methyl Residues Used for Acute Dietary Exposure 

Estimates.

US Environmental Protection Agency

DEEM-FCID Version 2.03 (1994-1996, 1998 data)

Filename: ThifensulfuronMethylDEEM022112AcuteInput.R98

Chemical: Thifensulfuron methyl

Reference Dose (Acute) = 1.59 mg/kg body weight/day

NOAEL (Acute) = 159 mg/kg body weight/day

Date created/last modified: 2/21/2012 at 14:15:38

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

15000250 15 Barley, pearled barley 0.050000 1.000 1.000 

15000251 15 Barley, pearled barley-babyfood 0.050000 1.000 1.000 

15000260 15 Barley, flour 0.050000 1.000 1.000 
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15000261 15 Barley, flour-babyfood 0.050000 1.000 1.000 

15000270 15 Barley, bran 0.050000 1.000 1.000 

01011000 1AB Chicory, roots 0.010000 1.000 1.000 1E7885

02001010 2 Chicory, tops 0.010000 1.000 1.000 1E7885

15001200 15 Corn, field, flour 0.050000 1.000 1.000 

15001201 15 Corn, field, flour-babyfood 0.050000 1.000 1.000 

15001210 15 Corn, field, meal 0.050000 1.000 1.000 

15001211 15 Corn, field, meal-babyfood 0.050000 1.000 1.000 

15001220 15 Corn, field, bran 0.050000 1.000 1.000 

15001230 15 Corn, field, starch 0.050000 1.000 1.000 

15001231 15 Corn, field, starch-babyfood 0.050000 1.000 1.000 

15001240 15 Corn, field, syrup 0.050000 1.500 1.000 

15001241 15 Corn, field, syrup-babyfood 0.050000 1.500 1.000 

15001250 15 Corn, field, oil 0.050000 1.000 1.000 

15001251 15 Corn, field, oil-babyfood 0.050000 1.000 1.000 

95001280 O Cottonseed, oil 0.020000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.020000 1.000 1.000 

20001630 20 Flaxseed, oil 0.020000 1.000 1.000 

15002310 15 Oat, bran 0.050000 1.000 1.000 

15002320 15 Oat, flour 0.050000 1.000 1.000 

15002321 15 Oat, flour-babyfood 0.050000 1.000 1.000 

15002330 15 Oat, groats/rolled oats 0.050000 1.000 1.000 

15002331 15 Oat, groats/rolled oats-babyfood 0.050000 1.000 1.000 

20003190 20 Rapeseed, oil 0.020000 1.000 1.000 

20003191 20 Rapeseed, oil-babyfood 0.020000 1.000 1.000 

15003230 15 Rice, white 0.050000 1.000 1.000 

15003231 15 Rice, white-babyfood 0.050000 1.000 1.000 

15003240 15 Rice, brown 0.050000 1.000 1.000 

15003241 15 Rice, brown-babyfood 0.050000 1.000 1.000 

15003250 15 Rice, flour 0.050000 1.000 1.000 

15003251 15 Rice, flour-babyfood 0.050000 1.000 1.000 

15003260 15 Rice, bran 0.050000 1.000 1.000 

15003261 15 Rice, bran-babyfood 0.050000 1.000 1.000 

20003300 20 Safflower, oil 0.050000 1.000 1.000 

20003301 20 Safflower, oil-babyfood 0.050000 1.000 1.000 

15003440 15 Sorghum, grain 0.050000 1.000 1.000 

15003450 15 Sorghum, syrup 0.050000 1.000 1.000 

06003470 6 Soybean, seed 0.100000 1.000 1.000 

06003480 6 Soybean, flour 0.100000 1.000 1.000 

06003481 6 Soybean, flour-babyfood 0.100000 1.000 1.000 

06003490 6 Soybean, soy milk 0.100000 1.000 1.000 

06003491 6 Soybean, soy milk-babyfood or in 0.100000 1.000 1.000 

06003500 6 Soybean, oil 0.100000 1.000 1.000 

06003501 6 Soybean, oil-babyfood 0.100000 1.000 1.000 

86010000 O Water, direct, all sources 0.004429 1.000 1.000 

86020000 O Water, indirect, all sources 0.004429 1.000 1.000 

15004010 15 Wheat, grain 0.050000 1.000 1.000 

15004011 15 Wheat, grain-babyfood 0.050000 1.000 1.000 

15004020 15 Wheat, flour 0.050000 1.000 1.000 

15004021 15 Wheat, flour-babyfood 0.050000 1.000 1.000 

15004030 15 Wheat, germ 0.050000 1.000 1.000 

15004040 15 Wheat, bran 0.050000 1.000 1.000 

15004050 15 Wild rice 0.050000 1.000 1.000 
Dietary Exposure and Risk Assessment

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Attachment 3. Summary of the Acute Dietary Exposure and Risk Estimates for 

Thifensulfuron Methyl. 

US Environmental Protection Agency

DEEM-FCID Version 2.03 (1994-1996, 1998 data)

DEEM-FCID Acute Analysis for thifensulfuron methyl

Analysis date: 2/21/2012 at 14:20:43

Residue file: ThifensulfuronMethylDEEM022112AcuteInput.R98

Residue file date: 2/21/2012 at 14:15:38

Reference Dose (Acute) = 1.59 mg/kg body weight/day

NOEL (Acute) = 159 mg/kg body weight/day

Daily totals for food and foodform consumption used.

Run Comment: Adjustment factor #2 NOT used.

===================================================================================

Summary calculations (per capita):

 95th Percentile 99th Percentile 99.9th Percentile

Exposure %aRfD MOE Exposure %aRfD MOE Exposure %aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Females 13-49 yrs:

 0.000544 0.03 292150 0.000746 0.05 213279 0.001097 0.07 144880 
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Attachment 4. Thifensulfuron Methyl Residues Used for Chronic Dietary Exposure 

Estimates.

US Environmental Protection Agency

DEEM-FCID Version 2.03 (1994-1996, 1998 data)

Filename: ThifensulfuronMethylDEEM102309ChronicInput.R98

Chemical: Thifensulfuron methyl

RfD (Chronic) = 0.043 mg/kg body weight/day

NOAEL (Chronic) = 4.3 mg/kg body weight/day

Date created/last modified: 2/21/2012 at 14:05:53

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

15000250 15 Barley, pearled barley 0.050000 1.000 1.000 

15000251 15 Barley, pearled barley-babyfood 0.050000 1.000 1.000 

15000260 15 Barley, flour 0.050000 1.000 1.000 

15000261 15 Barley, flour-babyfood 0.050000 1.000 1.000 

15000270 15 Barley, bran 0.050000 1.000 1.000 

01011000 1AB Chicory, roots 0.010000 1.000 1.000 1E7885

02001010 2 Chicory, tops 0.010000 1.000 1.000 1E7885

15001200 15 Corn, field, flour 0.050000 1.000 1.000 

15001201 15 Corn, field, flour-babyfood 0.050000 1.000 1.000 

15001210 15 Corn, field, meal 0.050000 1.000 1.000 

15001211 15 Corn, field, meal-babyfood 0.050000 1.000 1.000 

15001220 15 Corn, field, bran 0.050000 1.000 1.000 

15001230 15 Corn, field, starch 0.050000 1.000 1.000 

15001231 15 Corn, field, starch-babyfood 0.050000 1.000 1.000 

15001240 15 Corn, field, syrup 0.050000 1.500 1.000 

15001241 15 Corn, field, syrup-babyfood 0.050000 1.500 1.000 

15001250 15 Corn, field, oil 0.050000 1.000 1.000 

15001251 15 Corn, field, oil-babyfood 0.050000 1.000 1.000 

95001280 O Cottonseed, oil 0.020000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.020000 1.000 1.000 

20001630 20 Flaxseed, oil 0.020000 1.000 1.000 

15002310 15 Oat, bran 0.050000 1.000 1.000 

15002320 15 Oat, flour 0.050000 1.000 1.000 

15002321 15 Oat, flour-babyfood 0.050000 1.000 1.000 

15002330 15 Oat, groats/rolled oats 0.050000 1.000 1.000 

15002331 15 Oat, groats/rolled oats-babyfood 0.050000 1.000 1.000 

20003190 20 Rapeseed, oil 0.020000 1.000 1.000 

20003191 20 Rapeseed, oil-babyfood 0.020000 1.000 1.000 

15003230 15 Rice, white 0.050000 1.000 1.000 

15003231 15 Rice, white-babyfood 0.050000 1.000 1.000 

15003240 15 Rice, brown 0.050000 1.000 1.000 

15003241 15 Rice, brown-babyfood 0.050000 1.000 1.000 

15003250 15 Rice, flour 0.050000 1.000 1.000 

15003251 15 Rice, flour-babyfood 0.050000 1.000 1.000 

15003260 15 Rice, bran 0.050000 1.000 1.000 

15003261 15 Rice, bran-babyfood 0.050000 1.000 1.000 

20003300 20 Safflower, oil 0.050000 1.000 1.000 

20003301 20 Safflower, oil-babyfood 0.050000 1.000 1.000 

15003440 15 Sorghum, grain 0.050000 1.000 1.000 

15003450 15 Sorghum, syrup 0.050000 1.000 1.000 

06003470 6 Soybean, seed 0.100000 1.000 1.000 

06003480 6 Soybean, flour 0.100000 1.000 1.000 
Dietary Exposure and Risk Assessment

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06003481 6 Soybean, flour-babyfood 0.100000 1.000 1.000 

06003490 6 Soybean, soy milk 0.100000 1.000 1.000 

06003491 6 Soybean, soy milk-babyfood or in 0.100000 1.000 1.000 

06003500 6 Soybean, oil 0.100000 1.000 1.000 

06003501 6 Soybean, oil-babyfood 0.100000 1.000 1.000 

86010000 O Water, direct, all sources 0.001500 1.000 1.000 

86020000 O Water, indirect, all sources 0.001500 1.000 1.000 

15004010 15 Wheat, grain 0.050000 1.000 1.000 

15004011 15 Wheat, grain-babyfood 0.050000 1.000 1.000 

15004020 15 Wheat, flour 0.050000 1.000 1.000 

15004021 15 Wheat, flour-babyfood 0.050000 1.000 1.000 

15004030 15 Wheat, germ 0.050000 1.000 1.000 

15004040 15 Wheat, bran 0.050000 1.000 1.000 

15004050 15 Wild rice 0.050000 1.000 1.000 
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Attachment 5. Summary of the Chronic Dietary Exposure and Risk Estimates for 

Thifensulfuron Methyl. 

US Environmental Protection Agency DEEM-FCID Version 2.03 (1994-1996, 1998 data)

DEEM-FCID Chronic analysis for thifensulfuron methyl

Analysis Date: 2/21/2012 at 14:07:49

Residue file name: ThifensulfuronMethylDEEM022112ChronicInput.R98

Residue file date: 2/21/2012 at 14:05:53

Reference dose (Chronic) = 0.043 mg/kg body weight/day

NOAEL (Chronic) = 4.3 mg/kg body weight/day

Run Comment: Adjustment factor #2 NOT used. 

Total exposure by population subgroup

Total Exposure

Population Subgroup mg/kg bw/day %Rfd 

U.S. Population (total) 0.000284 0.7%

U.S. Population (spring season) 0.000288 0.7%

U.S. Population (summer season) 0.000288 0.7%

U.S. Population (autumn season) 0.000280 0.7%

U.S. Population (winter season) 0.000281 0.7%

Northeast region 0.000273 0.6%

Midwest region 0.000296 0.7%

Southern region 0.000274 0.6%

Western region 0.000298 0.7%

Hispanics 0.000308 0.7%

Non-hispanic whites 0.000276 0.6%

Non-hispanic blacks 0.000291 0.7%

Non-hisp/non-white/non-black 0.000335 0.8%

All infants (< 1 year) 0.000487 1.1%

Nursing infants 0.000185 0.4%

Non-nursing infants 0.000602 1.4%

Children 1-6 yrs 0.000602 1.4%

Children 7-12 yrs 0.000429 1.0%

Females 13-19 (not preg or nursing) 0.000270 0.6%

Females 20+ (not preg or nursing) 0.000196 0.5%

Females 13-50 yrs 0.000239 0.6%

Females 13+ (preg/not nursing) 0.000244 0.6%

Females 13+ (nursing) 0.000261 0.6%

Males 13-19 yrs 0.000348 0.8%

Males 20+ yrs 0.000236 0.5%

Seniors 55+ 0.000171 0.4%

Children 1-2 yrs 0.000602 1.4%

Children 3-5 yrs 0.000621 1.4%

Children 6-12 yrs 0.000447 1.0%

Youth 13-19 yrs 0.000310 0.7%

Adults 20-49 yrs 0.000239 0.6%

Adults 50+ yrs 0.000175 0.4%

Females 13-49 yrs 0.000226 0.5%