20862 Federal Register / Vol. 72, No. 80 / Thursday, April 26, 2007 / Notices 

1. Marker protein and target for 

antigen-specific immunotherapy in 

patients with malignant melanoma. 

2. Therapeutics and diagnostics for 

melanin-related disorders. 

Development Status: Early stage. 

Inventors: William J. Pavan and Stacie 

K. Loftus (NHGRI). 

Publications: Stacie K. Loftus, Denise 

M. Larson, Laura L. Baxter, Anthony 

Antonellis, Yidong Chen, Xufeng Wu, 

Yuan Jiang, Michael Bittner, John A. 

Hammer III, and William J. Pavan. 

Mutation of melanosome protein RAB38 

in chocolate mice. Proc Natl Acad Sci 

U.S.A. 2002 Apr 2;99(7):4471–4476. 

Patent Status: 

1. U.S. National Stage Application No. 

10/501,611 filed 20 Nov 2005, claiming 

priority to 18 Jan 2002 (HHS Reference 

No. E–315–2001/0–US–07). 

2. Foreign counterparts pending in 

Australia, Canada, Europe, and Japan. 

Licensing Status: Available for 

exclusive or non-exclusive licensing. 

Licensing Contact: Tara L. Kirby, 

Ph.D; 301/435–4426; 

tarak@mail.nih.gov. 

Novel Dmt-Tic Analogues Specific for 

Delta- and Mu-Opioid Receptors 

Description of Technology: Opioid 

receptor modulators, used historically 

for pain control, have more recently 

been shown to possess broader 

therapeutic potential in areas such as 

opiate and alcohol abuse, neurological 

disease or injury, neuropeptide or 

neurotransmitter imbalance, and 

immune system dysfunction. 

Furthermore, their interaction with key 

reward pathways presents interesting 

avenues for exploration in the treatment 

of food as an addictive substance, due 

to the fact that obesity is a major health 

problem in the U.S. Also, evidence of 

modulatory interactions between deltaand mu-opioid receptors has spurred 

interest in new opioid ligands 

possessing mixed and dual specificity 

for these receptors. These bifunctional 

compounds are particularly promising 

for treatment of addiction and treatment 

of pain with the elimination of drug 

tolerance. 

The inventors have developed a wide 

variety of highly selective Dmt-Tic 

analogues with potential therapeutic 

applications. These analogues include 

specific agonists and antagonists of the 

delta- and mu-opioid receptors and 

combinations thereof. 

Some disclosed analogues are di- and 

tri-peptidic derivatives of the Dmt-Tic 

pharmacophore; in addition to opioid 

receptor specificity, two of these 

derivatives have been shown to inhibit 

the activity of human multidrug 

resistance glycoprotein 1 (hMDR1) and 

may represent a novel chemosensitizing 

agent for treating cancer, and may also 

be used for reducing tolerance to 

morphine, the drug of choice in most 

hospitals around the world, thereby 

increasing its effectiveness. Also 

disclosed are compounds produced 

through derivatization of Dmt-Tic 

reference compounds with lysine, 

resulting in an unexpected and broad 

range of delta-and/or mu-opioid 

receptor modulation. The inventors 

have also prepared symmetric and 

asymmetric Dmt-Tic di-peptides that are 

potent dual delta- and mu-opioid 

receptor antagonists and that can pass 

through the gastrointestinal and bloodbrain barriers. Finally, the inventors 

have prepared various fluorescent DmtTic analogs that are useful for study of 

delta- and mu-opioid receptor structure 

and function. 

Applications: 

1. Potential opiate, food, and alcohol 

addiction therapeutics. 

2. Potential therapeutics for pain 

treatment. 

3. Potential therapeutics for cancer. 

4. Tools for screening ligand binding 

activity and differentiating between 

delta- and mu-opioid receptors. 

Market: 

1. In 2004, approximately 22 million 

Americans over the age of 12 required 

treatment for alcohol or illicit drug 

abuse and addiction; 13 million of these 

were classified as alcoholics. 

2. Approximately 50 million 

Americans suffer from pain, and an 

estimated 1.5 billion people suffer from 

moderate to severe pain worldwide. 

3. Two-thirds of the U.S. population 

is overweight, with a quarter designated 

as obese (9 million of whom are 

children); the number of overweight 

Americans doubled between 1980–1999 

and is predicted to increase 20% by 

2013 to 140 million. 

Development Status: In vitro data are 

available. 

Inventors: Lawrence H. Lazarus 

(NIEHS) et al. 

Publications: 

1. G. Balboni et al. Effect of lysine at 

C-terminus of the Dmt-Tic opioid 

pharmacophore. J Med Chem. 2006 Sep 

7;49(18):5610–5617. 

2. T Lovekamp et al. Inhibition of 

human multidrug resistance Pglycoprotein 1 by analogues of a potent 

delta-opioid antagonist. Brain Res. 2001 

May 25;902(1):131–134. 

3. T Li et al. Potent Dmt-Tic 

pharmacophoric delta- and mu-opioid 

receptor antagonists. J Med Chem. 2005 

Dec 15;48(25):8035–8044. 

4. T Li et al. Transformation of a muopioid agonist into biologically potent 

mu-opioid antagonists. Bioorg Med 

Chem. 2007 Feb 1;15(3):1237–1251. 

5. G. Balboni et al. Highly selective 

fluorescent analogue of the potent *eltaopioid receptor antagonist Dmt-Tic. J 

Med Chem. 2004 Dec 16:47(26):6541–

6546. 

Patent Status: 

1. U.S. Patent No. 6,753,317 issued 22 

Jun 2004 (HHS Reference No. E–103–

2000/0–US–02). 

2. U.S. Patent No. 6,916,905 issued 12 

Jul 2005 (HHS Reference No. E–103–

2000/1–US–01). 

3. U.S. Patent Application No. 10/ 

280,752 filed 16 Nov 2005 (HHS 

Reference No. E–103–2000/2–US–02). 

4. U.S. Provisional Application No. 

60/834,438 filed 31 Jul 2006 (HHS 

Reference No. E–103–2000/3–US–01). 

5. PCT Application No. PCT/US06/ 

33560 filed 30 Aug 2006 (HHS 

Reference No. E–305–2005/0–PCT–02). 

Licensing Status: Available for 

exclusive or nonexclusive licensing. 

Licensing Contact: Tara L. Kirby, PhD; 

301/435–4426; tarak@mail.nih.gov. 

Dated: April 17, 2007. 

Steven M. Ferguson, 

Director, Division of Technology Development 

and Transfer, Office of Technology Transfer, 

National Institutes of Health. 

[FR Doc. E7–7933 Filed 4–25–07; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HOMELAND 

SECURITY 

Coast Guard 

[USCG–2007–27858] 

National Boating Safety Advisory 

Council; Vacancies 

AGENCY: Coast Guard, DHS. 

ACTION: Request for applications. 

SUMMARY: The Coast Guard seeks 

applications for membership on the 

National Boating Safety Advisory 

Council (NBSAC). NBSAC advises the 

Coast Guard on matters related to 

recreational boating safety. 

DATES: Application forms should reach 

us on or before August 17, 2007. 

ADDRESSES: You may request an 

application form by writing to 

Commandant, Office of Boating Safety 

(CG–3PCB–1), U.S. Coast Guard, 2100 

Second Street, SW., Washington, DC 

20593–0001; by calling 202–372–1062; 

or by faxing 202–372–1932. Send your 

application in written form to the above 

street address. This notice and the 

application form are also available on 

the Internet at: http:// 

www.uscgboating.org/nbsac/nbsac.htm. 

FOR FURTHER INFORMATION CONTACT: Mr. 

Jeff Ludwig, Executive Secretary of 


rwilkins on PROD1PC63 with NOTICES
Federal Register / Vol. 72, No. 80 / Thursday, April 26, 2007 / Notices 20863 

NBSAC, telephone 202–372–1062, fax 

202–372–1932, or e-mail: 

jeffrey.a.ludwig@uscg.mil. 

SUPPLEMENTARY INFORMATION: The 

National Boating Safety Advisory 

Council (NBSAC) is a Federal advisory 

committee under 5 U.S.C. App. 2. It 

advises the Coast Guard regarding 

regulations and other major boating 

safety matters. NBSAC’s 21 members are 

drawn equally from the following three 

sectors of the boating community: State 

officials responsible for State boating 

safety programs, recreational boat and 

associated equipment manufacturers, 

and national recreational boating 

organizations and the general public. 

Members are appointed by the Secretary 

of the Department of Homeland 

Security. 

NBSAC normally meets twice each 

year at a location selected by the Coast 

Guard. When attending meetings of the 

Council, members are provided travel 

expenses and per diem. 

We will consider applications 

received in response to this notice for 

the following seven positions that 

expire or become vacant in December 

2007: Two representatives of State 

officials responsible for State boating 

safety programs, three representatives of 

recreational boat and associated 

equipment manufacturers, and two 

representatives of the general public or 

national recreational boating 

organizations. 

Applicants are considered for 

membership on the basis of their 

particular expertise, knowledge, and 

experience in recreational boating 

safety. Prior applicants should submit 

an updated application to ensure 

consideration for the vacancies 

announced in this notice. Each member 

serves for a term of up to 3 years. 

Members may reapply to serve a 

consecutive term. In support of the 

policy of the U.S. Coast Guard on 

gender and ethnic diversity, we 

encourage qualified women and 

members of minority groups to apply. 

If you are selected as a member who 

represents the general public, we will 

require you to complete a Confidential 

Financial Disclosure Report (OGE Form 

450). We may not release the report or 

the information in it to the public, 

except under an order issued by a 

Federal court or as otherwise provided 

under the Privacy Act (5 U.S.C. 552a). 

Dated: April 18, 2007. 

F.J. Sturm, 

Captain, U.S. Coast Guard, Acting Director 

of Inspections and Compliance. 

[FR Doc. E7–7947 Filed 4–25–07; 8:45 am] 

BILLING CODE 4910–15–P 

DEPARTMENT OF HOMELAND 

SECURITY 

Coast Guard 

[CGD08–07–009] 

Lower Mississippi River Waterway 

Safety Advisory Committee 

AGENCY: Coast Guard, DHS. 

ACTION: Notice of meeting. 

SUMMARY: The Lower Mississippi River 

Waterway Safety Advisory Committee 

(LMRWSAC) will meet to discuss 

various issues relating to navigational 

safety on the Lower Mississippi River 

and related waterways. The meeting 

will be open to the public. 

DATES: The next meeting of LMRWSAC 

will be held on Wednesday, May 23, 

2007, from 9 a.m. to 12 p.m. This 

meeting may adjourn early if all 

business is finished. Requests to make 

oral presentations or submit written 

materials for distribution at the meeting 

should reach the Coast Guard on or 

before May 9, 2007. Requests to have a 

copy of your material distributed to 

each member of the committee in 

advance of the meeting should reach the 

Coast Guard on or before May 9, 2007. 

ADDRESSES: The meeting will be held in 

the World Trade Center of New Orleans, 

2 Canal Street, 18th Floor, New Orleans, 

LA 70130. This notice is available on 

the Internet at http://dms.dot.gov. 

FOR FURTHER INFORMATION CONTACT: 

Lieutenant Junior Grade (LTJG) Thao 

Nguyen, Assistant Committee 

Administrator, e-mail 

thao.v.nguyen@uscg.mil, telephone 

(504) 589–6196 extension 369. Written 

materials and requests to make 

presentations should be mailed to 

Commanding Officer, USCG Sector New 

Orleans, Attn: Waterways Management, 

1615 Poydras St, New Orleans, LA 

70112. 

SUPPLEMENTARY INFORMATION: Notice of 

this meeting is given under the Federal 

Advisory Committee Act, 5 U.S.C. App. 

2. 

Agenda of Meeting 

Lower Mississippi River Waterway 

Safety Advisory Committee 

(LMRWSAC). The agenda includes the 

following: 

(1) Introduction of committee 

members. 

(2) Opening Remarks. 

(3) Approval of the December 14, 

2006 minutes. 

(4) Old Business: 

(a) Captain of the Port status report. 

(b) VTS update report. 

(c) Subcommittee / Working Group 

update reports. 

(5) New Business. 

(6) Adjournment. 

Procedural 

The meeting is open to the public. 

Please note that the meeting may close 

early if all business is finished. At the 

Chair’s discretion, members of the 

public may make oral presentations 

during the meeting. If you would like to 

make an oral presentation at the 

meeting, please notify the Committee 

Administrator no later than May 9, 

2007. Written material for distribution 

at the meeting should reach the Coast 

Guard no later than May 9, 2007. If you 

would like a copy of your material 

distributed to each member of the 

committee in advance of the meeting, 

please submit 25 copies to the 

Committee Administrator no later than 

May 9, 2007. 

Information on Services for Individuals 

with Disabilities 

For information on facilities or 

services for individuals with 

disabilities, or to request special 

assistance at the meetings, contact the 

Committee Administrator at the location 

indicated under Addresses as soon as 

possible. 

Dated: April 13, 2007. 

Richard G. Sullivan, 

Captain, U.S. Coast Guard, Commander, 

Eighth Coast Guard District, Acting. 

[FR Doc. E7–7941 Filed 4–25–07; 8:45 am] 

BILLING CODE 4910–15–P 

DEPARTMENT OF HOMELAND 

SECURITY 

Coast Guard 

[USCG–2007–27656] 

High Frequency (HF) Radio Broadcasts 

of Marine Weather Forecasts and 

Warnings 

AGENCY: Coast Guard, DHS. 

ACTION: Notice; request for public 

comments. 

SUMMARY: The Coast Guard is soliciting 

public comment on the need to continue 

providing high frequency (HF) radio 

broadcasts of weather forecasts and 

warnings. Public comment is necessary 

in order to assess the demand for the HF 

radio broadcasts of weather forecasts in 

each of three forms: (1) Radiofacsimile; 

(2) voice; and, (3) Simplex Teletype 

Over Radio (SITOR), also known as 

Narrow Band Direct Printing (NBDP). 

The infrastructure necessary to provide 

these services has exceeded its life 

expectancy; the equipment is no longer 

manufactured, repairs are difficult to 


rwilkins on PROD1PC63 with NOTICES