Federal Register / Vol. 72, No. 81 / Friday April 27, 2007 / Notices 21021 

Affected Public: Not-for-profit 

institutions. 

Annual Number of Respondents: 833. 

Total Annual Responses: 833. 

Average Burden per Response: 34 

minutes. 

Total Annual Hours: 472. 

To obtain copies of the supporting 

statement and any related forms for the 

proposed paperwork collections 

referenced above, e-mail your request, 

including your address, phone number, 

OMB number, and OS document 

identifier, to 

Sherette.funncoleman@hhs.gov, or call 

the Reports Clearance Office on (202) 

690–6162. Written comments and 

recommendations for the proposed 

information collections must be 

received within 30 days of this notice 

directly to the Desk Officer at the 

address below: OMB Desk Officer: John 

Kraemer, OMB Human Resources and 

Housing Branch, Attention: (OMB 

#0990–New), New Executive Office 

Building, Room 10235, Washington, DC 

20503. 

Dated: April 17, 2007. 

Alice Bettencourt, 

Office of the Secretary, Paperwork Reduction 

Act Reports Clearance Officer. 

[FR Doc. E7–8050 Filed 4–26–07; 8:45 am] 

BILLING CODE 4150–33–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

Centers for Disease Control and 

Prevention 

[60Day–07–07AW] 

Proposed Data Collections Submitted 

for Public Comment and 

Recommendations 

In compliance with the requirement 

of Section 3506(c)(2)(A) of the 

Paperwork Reduction Act of 1995 for 

opportunity for public comment on 

proposed data collection projects, the 

Centers for Disease Control and 

Prevention (CDC) will publish periodic 

summaries of proposed projects. To 

request more information on the 

proposed projects or to obtain a copy of 

the data collection plans and 

instruments, call 404–639–5960 and 

send comments to Joan Karr, CDC 

Acting Reports Clearance Officer, 1600 

Clifton Road, MS–D74, Atlanta, GA 

30333 or send an e-mail to 

omb@cdc.gov. 

Comments are invited on: (a) Whether 

the proposed collection of information 

is necessary for the proper performance 

of the functions of the agency, including 

whether the information shall have 

practical utility; (b) the accuracy of the 

agency’s estimate of the burden of the 

proposed collection of information; (c) 

ways to enhance the quality, utility, and 

clarity of the information to be 

collected; and (d) ways to minimize the 

burden of the collection of information 

on respondents, including through the 

use of automated collection techniques 

or other forms of information 

technology. Written comments should 

be received within 60 days of this 

notice. 

Proposed Project 

Experimental and Theoretical Study 

of Early Detection and Isolation of 

Influenza—NEW—The National 

Institute for Occupational Safety and 

Health (NIOSH), Centers for Disease 

Control and Prevention (CDC). 

Background and Brief Description 

The Federal Occupational Safety and 

Health Act of 1970, section 501, enables 

NIOSH to carry out research relevant to 

the health and safety of workers. Some 

diseases like influenza and Severe 

Acute Respiratory Syndrome (SARS) 

can be spread when people produce 

clouds of droplets (called aerosols) by 

coughing or sneezing. Aerosol 

transmission of infectious diseases is of 

particular interest today because of 

increased concern over a possible global 

influenza pandemic. The possible 

airborne spread of influenza is 

especially important to health-care 

workers and emergency responders, 

who face a much greater risk of 

exposure than does the general public. 

However, substantial gaps exist in our 

understanding of the generation and 

spread of infectious aerosols containing 

influenza. This lack of information 

hampers the ability of health scientists 

to model and predict the transmission of 

influenza by airborne particles and to 

understand whether or not aerosols are 

likely to be an important route of 

transmission of influenza during a 

pandemic. 

The purpose of this study is to gain 

a better understanding of the production 

and dissemination of aerosols 

containing the influenza virus. The 

results of this research will give 

scientists and health professional’s 

greater insight into the airborne 

transmission of influenza and allow 

them to better assess the potential 

effectiveness of preventive measures. 

The first part of this study will 

measure the quantity and size 

distribution of aerosol droplets 

produced by people with influenza 

when they cough. To accomplish this, 

volunteers with influenza-like illness 

will be asked to provide an oral swab for 

influenza testing, and then will cough 

into a spirometer. The aerosol produced 

by each person will be measured using 

commercially-available instrumentation. 

The oral swabs will be processed after 

the aerosol experiments are completed. 

The second part of this study will 

determine the amount and size of 

airborne particles containing influenza 

virus that are present in a hospital 

emergency department during influenza 

season. Health care workers will be 

recruited to wear small aerosol 

collection devices as they go about their 

normal duties. The collected samples 

will then be analyzed for influenza 

virus. Adult patients in the emergency 

department with influenza-like illness 

will be asked to provide an oral swab to 

test for the flu virus in order to estimate 

the number of potential sources of viralladen airborne particles. There will be 

no costs to study participants other than 

their time. 

ESTIMATED ANNUALIZED BURDEN HOURS

Respondents Number of 

respondents 

Number of 

responses per 

respondent 

Average 

burden per 

response 

(in hours) 

Total burden 

(in hours) 

Part 1 participants .......................................................................................... 40 2 1 80 

Part 2 health care workers ............................................................................ 30 1 1 30 

Part 2 patients ............................................................................................... 15 1 0.5 8 .0 

Total ........................................................................................................ ........................ ........................ ........................ 118 


cprice-sewell on PROD1PC66 with NOTICES
21022 Federal Register / Vol. 72, No. 81 / Friday April 27, 2007 / Notices 

Dated: April 23, 2007. 

Joan F. Karr, 

Acting Reports Clearance Officer, Centers for 

Disease Control and Prevention. 

[FR Doc. E7–8073 Filed 4–26–07; 8:45 am] 

BILLING CODE 4163–18–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

Centers for Disease Control and 

Prevention 

[60Day–07–07AY] 

Proposed Data Collections Submitted 

for Public Comment and 

Recommendations 

In compliance with the requirement 

of section 3506(c)(2)(A) of the 

Paperwork Reduction Act of 1995 for 

opportunity for public comment on 

proposed data collection projects, the 

Centers for Disease Control and 

Prevention (CDC) will publish periodic 

summaries of proposed projects. To 

request more information on the 

proposed projects or to obtain a copy of 

the data collection plans and 

instruments, call 404–639–5960 and 

send comments to Joan Karr, CDC 

Acting Reports Clearance Officer, 1600 

Clifton Road, MS–D74, Atlanta, GA 

30333 or send an e-mail to 

omb@cdc.gov. 

Comments are invited on: (a) Whether 

the proposed collection of information 

is necessary for the proper performance 

of the functions of the agency, including 

whether the information shall have 

practical utility; (b) the accuracy of the 

agency’s estimate of the burden of the 

proposed collection of information; (c) 

ways to enhance the quality, utility, and 

clarity of the information to be 

collected; and (d) ways to minimize the 

burden of the collection of information 

on respondents, including through the 

use of automated collection techniques 

or other forms of information 

technology. Written comments should 

be received within 60 days of this 

notice. 

Proposed Project 

Long-Term Efficacy of a Program to 

Prevent Beryllium Disease—New—

National Institute for Occupational 

Safety and Health (NIOSH), Centers for 

Disease Control and Prevention (CDC). 

Background and Brief Description 

Beryllium is a lightweight metal with 

many applications. Exposed workers 

may be found in the primary 

production, nuclear power and 

weapons, aerospace, scrap metal 

reclamation, specialty ceramics, and 

electronics industries, among others. 

The size of the USA workforce at risk 

of chronic beryllium disease (CBD), 

from either current or past work-related 

exposure to the metal, may be as high 

as one million. Demand for beryllium is 

growing worldwide, which means that 

increasing numbers of workers are likely 

to be exposed. 

Exposure to beryllium can lead to 

sensitization and cause an immunologic 

granulomatous lung disease. 

Sensitization is a cell-mediated allergictype response that may be detected in 

the peripheral blood with the beryllium 

lymphocyte proliferation test (BeLPT), 

which is used by the industry as a 

surveillance tool. Workers found to be 

sensitized may be clinically evaluated 

for CBD with tests including 

bronchoalveolar lavage and 

transbronchial biopsy. Cross-sectional 

studies in various beryllium workplace 

populations have identified 

sensitization in the range of less than 

1% to 14% of workers. The proportion 

of sensitized workers who have 

beryllium disease at initial clinical 

evaluation has varied from 10 to 100% 

in different workplaces. Sensitized 

workers not initially diagnosed with 

CBD are often diagnosed with the 

disease upon follow-up, but whether all 

sensitized workers will eventually 

develop beryllium disease is unknown. 

Industry screening programs have 

enabled the identification of CBD in 

persons without apparent symptoms, 

often early in disease progression (often 

referred to as ‘‘subclinical disease’’). 

Progression from sensitization to 

subclinical disease to clinical 

impairment, while difficult to predict 

for any one individual, is not 

uncommon. 

Currently, there are no preventive 

programs that have been demonstrated 

to have long-term effectiveness in 

preventing beryllium sensitization and 

CBD among beryllium-exposed workers. 

In the United States, recent short-term 

evidence (i.e., average work tenure 16 

months, maximum four years) at one 

facility suggests that the comprehensive 

preventive program that was 

implemented by company management 

beginning in 2000 has successfully 

reduced the incidence of beryllium 

sensitization, as defined by the 

occurrence of confirmed abnormal 

BeLPTs. However, the follow-up has 

thus far been limited to current workers, 

the duration has been too short to 

document a reduced incidence of CBD, 

and it is possible that sensitization has 

been delayed, rather than prevented. 

Evaluation of this program’s 

effectiveness would therefore be more 

complete by including individuals who 

have left employment and documenting 

whether: (1) The program was effective 

at two other facilities at which it was 

implemented, (2) the program prevented 

beryllium sensitization over a longer 

period of time (i.e., up to eight years); 

and (3) the program prevented CBD, 

which generally takes longer to develop. 

Study Design 

This proposed study is designed to 

evaluate the effectiveness of a 

comprehensive preventive program at 

three beryllium plants. Eligible workers 

for this survey include those hired 

between implementation of a 

comprehensive program (2000–01) and 

December 31, 2008, including any 

already known to be sensitized. NIOSH 

will offer all eligible current and former 

workers the BeLPT to identify 

sensitization and administer a work and 

medical history questionnaire. 

There are no costs to former worker 

respondents except their time to 

participate in the interview. Current 

workers will participate during work 

hours, and will thus be compensated for 

their time by their employer. Former 

workers will participate during their 

own time. 

ESTIMATE OF ANNUALIZED BURDEN HOURS

Respondents Number of 

respondents 

Number of 

responses/respondent 

Avg. burden/ 

response 

(in hours) 

Total burden 

(in hours) 

Current Workers .............................................................................................. 239 1 45/60 179 

Former Workers ............................................................................................... 340 1 45/60 255 

Total .......................................................................................................... 579 434 


cprice-sewell on PROD1PC66 with NOTICES