Exhibit 4.2


 


BIOXCEL THERAPEUTICS,
INC.

REGISTRATION RIGHTS AGREEMENT


 


This Registration
Rights Agreement (this “Agreement”) is made as of April 19, 2022, by and among BioXcel Therapeutics,
Inc., a Delaware corporation (the “Company”), the purchasers identified on Schedule A hereto (each, a
 “Purchaser”) and such other Persons, if any, from time to time, that become a party hereto as holders of Registrable
Securities (as defined below).


 


RECITALS


 


Whereas,
pursuant to the Credit Agreement (as defined below), on the Closing Date (as defined below), the Company will issue to each Purchaser
a warrant to purchase such number of shares of Common Stock (as defined below) as is set forth opposite such Purchaser’s name on
Schedule A hereto (as such number may be adjusted pursuant to the terms of such warrant) (each, a “Warrant”
and collectively, the “Warrants”);


 


Whereas,
the Warrants will be exercisable for shares of Common Stock from time to time on or after the Closing Date and on or prior to the close
of business on April 19, 2029, in accordance with the terms thereof;


 


Whereas,
in connection with the execution and delivery of the Credit Agreement and the issuance of the Warrants and the consummation of the transactions
contemplated thereby the Company has agreed to grant the Holders (as defined below) certain registration rights as set forth below; and


 


Now,
Therefore, in consideration of the mutual promises and covenants herein contained, and other consideration, the receipt and
adequacy of which is hereby acknowledged, the parties hereto agree as follows:


 


Article
I

Definitions


 


1.1             
Definitions. Unless otherwise defined herein, capitalized terms used in this Agreement have the meanings ascribed
to them in the Credit Agreement. As used in this Agreement, the following terms shall have the meanings set forth below:


 


(a)              
“Additional Shares” means any shares of Common Stock issued to the Purchasers pursuant to a stock
split, stock dividend or other distribution with respect to, or in exchange or in replacement of, the Underlying Shares, or in connection
with a combination of shares, distribution, recapitalization, merger, consolidation, other reorganization or other similar event.


 


(b)              
“Agreement” has the meaning set forth in the Preamble.


 






     


     


    

 


(c)              
 “Business Day” means any day, excluding Saturday, Sunday and any day which is a legal holiday
in the City of New York or is a day on which banking institutions located in the City of New York are authorized or required by law or
other governmental action to remain closed.


 


(d)              
“Change of Control” means an event or series of events (i) as a result of which any “person”
or “group” (as such terms are used in Sections 13(d) and 14(d) of the Securities Act, but excluding any of such person or
its Subsidiaries, and any Person acting in its capacity as trustee, agent or other fiduciary or administrator of any such Plan and excluding
any Permitted Holder becomes the “beneficial owner”, directly or indirectly, of thirty-five percent (35%) or more of the Equity
Interests of the Company entitled to vote for members of the Board of the Company on a fully-diluted basis (and taking into account all
such Equity Interests that such person or group has the right to acquire pursuant to any Option Right); (ii) as a result of which any
Permitted Holder or “group” (as such terms are used in Sections 13(d) and 14(d) of the Securities Act) including any Permitted
Holder becomes the “beneficial owner”, directly or indirectly, of forty-five percent (45%) or more of the Equity Interests
of the Company entitled to vote for members of the Board of the Company on a fully-diluted basis (and taking into account all such Equity
Interests that such Permitted Holder or group has the right to acquire pursuant to any Option Right); (iii) that results in the sale of
all or substantially all of the assets or businesses of the Company and its Subsidiaries, taken as a whole, or (iv) that results in the
Company’s failure to own, directly or indirectly, beneficially and of record, one-hundred percent (100%) of all issued and outstanding
Equity Interests of each Subsidiary Guarantor (other than, in the case of this clause (iv), as a result of any Asset Sale permitted by
Section 9.09 of the Credit Agreement, liquidation or dissolution permitted by Section 9.03(b) of the Credit Agreement, the issuance of
any Equity Interests in BXCL 701 Subsidiaries pursuant to Section 9.09(o) of the Credit Agreement or a Permitted BXCL 701 Disposition
Event, or any interest in or exercise of any 701 Warrant). For purposes of this definition, “beneficial owner” is as defined
in Rules 13d-3 and 13d-5 under the Exchange Act, except that a person or group shall be deemed to have “beneficial ownership”
of all Equity Interests that such person or group has the right to acquire, whether such right is exercisable immediately or only after
the passage of time (such right, an “Option Right”).


 


(e)              
“Closing Date” has the meaning set forth in the Credit Agreement.


 


(f)               
“Common Stock” means shares of the common stock of the Company, par value $0.001 per share.


 


(g)              
“Company” has the meaning set forth in the Preamble.


 


(h)              
“Company Indemnified Party” has the meaning set forth in Section 2.4(b).


 


(i)                
“Controlling Person” has the meaning set forth in Section 2.4(a).


 






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(j)                
 “Credit Agreement” means that certain Credit Agreement and Guaranty (as may be amended or restated
from time to time), dated as of April 19, 2022, by and among the Company, the subsidiaries of the Company party thereto as Guarantors,
the lenders party thereto and Oaktree Fund Administration, LLC, as administrative agent.


 


(k)              
“Default” has the meaning set forth in Section 2.1(c).


 


(l)                
“Effectiveness Deadline” means the Shelf Effectiveness Deadline and the Subsequent Shelf Effectiveness
Deadline.


 


(m)            
“End of Suspension Notice” has the meaning set forth in Section 2.2(c).


 


(n)              
“Holder” (collectively, “Holders”) means any Purchaser and any transferee
permitted under Section 3.1, in each case, to the extent holding or beneficially owning Registrable Securities or Warrants exercisable
for Registrable Securities.


 


(o)              
“Holder Indemnified Parties” has the meaning set forth in Section 2.4(a).


 


(p)              
“Indemnified Party” has the meaning set forth in Section 2.4(c).


 


(q)              
“Liquidated Damages” has the meaning set forth in Section 2.1(c).


 


(r)               
“Option Right” has the meaning set forth in the definition of “Change of Control”.


 


(s)               
“Person” means any person, individual, corporation,
limited liability company, partnership, trust or other nongovernmental entity or any governmental agency, court, authority or other body
(whether foreign, federal, state, local or otherwise).


 


(t)                
“Prospectus” means the prospectus or prospectuses (whether preliminary or final) included in any
Registration Statement and relating to Registrable Securities, as amended or supplemented and including all material incorporated by reference
in such prospectus or prospectuses.


 


(u)              
“Purchaser” has the meaning set forth in the Recitals.


 


(v)              
“register,” “registered” and “registration”
refer to a registration effected by filing with the SEC a registration statement in compliance with the Securities Act, and the declaration
or ordering by the SEC of the effectiveness of such registration statement.


 


(w)             “Registrable
Securities” means (i) the Underlying Shares, and (ii) any Additional Shares; provided, however, that Underlying
Shares or Additional Shares shall cease to be treated as Registrable Securities on the earliest to occur of, (A) the date such
security has been disposed of pursuant to an effective registration statement, (B) the date on which such security is sold pursuant
to Rule 144 or (C) the date on which the Holder thereof, together with its Affiliates, is able to dispose of all of its Registrable
Securities without restriction or limitation pursuant to Rule 144 and without the requirement for the Company to be in compliance
with Rule 144 (or any successor rule).


 






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(x)              
“Registration Expenses” means any and all expenses incident to the Company’s performance
of or compliance with this Agreement, including without limitation: (i) all SEC registration and filing fees, (ii) all fees and expenses
associated with filings to be made with, or the listing of any Registrable Securities on, any securities exchange or over-the-counter
trading market on which the Registrable Securities are to be listed or quoted, (iii) all fees and expenses with respect to filings required
to be made with an exchange or any securities industry self-regulatory body, (iv) all fees and expenses of compliance with securities
or “blue sky” laws (including fees and disbursements of counsel for the Company in connection therewith), (v) all transfer
agent’s and registrar’s fees, (vi) all fees and disbursements of counsel for the Company and customary fees and expenses for
independent certified public accountants retained by the Company, (vii) securities acts liability insurance, if the Company so desires,
(viii) all internal expenses of the Company (including, without limitation, all salaries and expenses of its officers and employees performing
legal or accounting duties), (ix) the expense of any annual audit, and (x) the fees and expenses of any Person, including special
experts, retained by the Company. “Registration Expenses” shall not include underwriting discounts or commissions
attributable to the sale of the Registrable Securities or any legal fees and expenses of counsel to the Holders.


 


(y)              
“Registration Statement” means any registration statement of the Company under the Securities
Act which covers any of the Registrable Securities pursuant to the provisions of this Agreement, including the Prospectus, all amendments
and supplements to such Registration Statement, including post-effective amendments, all exhibits and all documents incorporated by reference
in such Registration Statement.


 


(z)              
“Rule 144” means Rule 144 under the Securities Act.


 


(aa)           
“SEC” means the U.S. Securities and Exchange Commission.


 


(bb)          
“Securities Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated
thereunder, as the same may be amended from time to time.


 


(cc)           
“Shelf Effectiveness Deadline” has the meaning set forth in Section 2.1(b).


 


(dd)          
“Shelf Registration” has the meaning set forth in Section 2.1(a).


 


(ee)           
“Shelf Registration Statement” has the meaning set forth in Section 2.1(a).


 


(ff)             
“Subsequent Shelf Effectiveness Deadline” has the meaning set forth in Section 2.1(b).


 






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(gg)          
 “Subsequent Shelf Registration Statement” has the meaning set forth in Section 2.1(b).


 


(hh)          
“Suspension Event” has the meaning set forth in Section 2.2(b).


 


(ii)             
“Suspension Notice” has the meaning set forth in Section 2.2(c).


 


(jj)             
“Termination Date” has the meaning set forth in Section 2.1(b).


 


(kk)          
"Trading Day” means a day on which the Common Stock is traded on a Trading Market or, if the Common
Stock is not traded on a Trading Market, then on the principal securities exchange or securities market on which the Common Stock is then
traded.


 


(ll)             
“Trading Market” means any market or exchange of The Nasdaq Stock Market LLC or the New York Stock
Exchange.


 


(mm)         
“Underlying Shares” means any and all shares of Common Stock issuable upon exercise of the Warrants.


 


(nn)          
 “Warrant” has the meaning set forth in the Recitals.


 


Article
II

Registration Rights


 


2.1             
Shelf Registration.


 


(a)              
Filing. Within 45 days following the date hereof, the Company shall file with the SEC a Registration Statement on
Form S-3 (unless the Company is ineligible to register for resale the Registrable Securities on Form S-3, in which case such registration
shall be on another appropriate form) or the then appropriate form for an offering to be made on a delayed or continuous basis pursuant
to Rule 415 under the Securities Act or any successor rule thereto (a “Shelf Registration Statement”) pursuant
to which all of the Registrable Securities shall be included (on the initial filing or by supplement or amendment thereto) to enable the
public resale of the Registrable Securities on a delayed or continuous basis pursuant to Rule 415 under the Securities Act or any successor
rule thereto (a “Shelf Registration”). If permitted under the Securities Act, such Shelf Registration Statement
shall be an “automatic shelf registration statement” as defined in Rule 405 under the Securities Act.


 






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(b)               Effectiveness.
The Company shall use its reasonable best efforts to (i) cause the Shelf Registration Statement filed pursuant to Section
2.1(a) to be declared effective by the SEC as soon as reasonably practicable, and in any event by the date that is the earlier
of (A) 120 days following the date hereof and (B) five Trading Days after the date the Company receives written notification from
the SEC that the Shelf Registration will not be reviewed (the “Shelf Effectiveness Deadline”) and
(ii) maintain the effectiveness of such Shelf Registration Statement, including by filing any necessary post-effective
amendments and Prospectus supplements and by filing one or more replacement or renewal Shelf Registration Statements (each, a
 “Subsequent Shelf Registration Statement”) upon the expiration of such Shelf Registration Statement, if
required by Rule 415 under the Securities Act, continuously until the earliest to occur of (1) the 30-month anniversary of the date
hereof, (2) a Change of Control and (3) such time as there are no Registrable Securities remaining or issuable upon exercise of the
Warrants (the “Termination Date”). If a Subsequent Shelf Registration Statement is filed, the Company
shall use its reasonable best efforts to (i) cause such Subsequent Shelf Registration Statement to be declared effective by the SEC
as soon as reasonably practicable after such filing, but in any event by the date that is fifty (50) days after such Subsequent
Shelf Registration Statement is filed (the “Subsequent Shelf Effectiveness Deadline”), and (ii) keep
such Subsequent Shelf Registration Statement (or another Subsequent Shelf Registration Statement) continuously effective until the
Termination Date. Any Subsequent Shelf Registration Statement shall be a Shelf Registration Statement.


 


(c)              
Default. In the event that (i) the Shelf Registration Statement filed pursuant to Section 2.1(a) is not declared
effective by the SEC by the Shelf Effectiveness Deadline, (ii) a Subsequent Shelf Registration Statement (if required to be filed pursuant
to Section 2.1(b)) is not filed by the Subsequent Shelf Effectiveness Deadline, or (iii) after a Shelf Registration Statement has
been declared effective, sales cannot be made continuously pursuant to such Shelf Registration Statement for any reason (including without
limitation by reason of a stop order, or the Company’s failure to update the Shelf Registration Statement), other than, in each
case, during the time period(s) permitted by Section 2.2(b) (each such event, a “Default”), then, in
addition to any other rights a Holder may have hereunder or under applicable law, on the first day of the occurrence of the Default, and
on the same day of each succeeding month (if the applicable Default shall not have been cured by such date) until the applicable Default
is cured, the Company shall pay to each Holder an amount in cash, as liquidated damages and not as a penalty (the “Liquidated
Damages”), on the date of the Default and the same day each succeeding month, equal to 1% of the aggregate purchase price
paid for the Registrable Securities held by such Holder. The parties agree that in no event shall the aggregate amount of Liquidated Damages
payable to any Holder exceed, in the aggregate, twenty-five percent (25%) of the aggregate purchase price paid for the Registrable Securities
held by such Holder. If the Company fails to pay any Liquidated Damages pursuant to this Section 2.1(c) in full within five (5)
Business Days after the date payable, the Company will pay interest thereon at a rate of 1.5% per month (or such lesser maximum amount
that is permitted to be paid by applicable law) to each Holder, accruing daily from the date such Liquidated Damages are due until such
amounts, plus all such interest thereon, are paid in full. The Liquidated Damages pursuant to the terms hereof shall apply on a daily
pro-rata basis for any portion of a month prior to the cure of a Default, except in the case of the first occurrence of the Default. The
applicable Effectiveness Deadline shall be extended without Default or Liquidated Damages hereunder in the event that the Company’s
failure to obtain the effectiveness of such Shelf Registration Statement or Subsequent Shelf Registration Statement on a timely basis
results from the failure of any Holder to timely provide the Company with information requested by the Company and necessary to complete
the Shelf Registration Statement or Subsequent Shelf Registration Statement in accordance with the requirements of the Securities Act
(in which case the applicable Effectiveness Deadline would be extended with respect to Registrable Securities held by such Holder).


 






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(d)              
 Additional Selling Stockholders. At any time and from time to time that a Shelf Registration Statement is effective,
if a Holder of Registrable Securities requests that such Holder be added as a selling stockholder in such Shelf Registration Statement,
the Company shall as promptly as practicable amend or supplement the Shelf Registration Statement to cover such Holder.


 


2.2             
Provisions Relating to Registration.


 


(a)              
If and whenever the Company is required to effect the registration of any Registrable Securities pursuant to this Agreement,
the Company shall use its reasonable best efforts to effect and facilitate the registration of such Registrable Securities as promptly
as is practicable and, pursuant thereto, the Company shall as expeditiously as possible and as applicable:


 


(i)               
prepare and file with the SEC a Registration Statement with respect to such Registrable Securities, make all required filings
required in connection therewith and (if the Registration Statement is not automatically effective upon filing) use its reasonable best
efforts to cause such Registration Statement to become effective as promptly as practicable; provided that before filing a Registration
Statement or any amendments or supplements thereto, the Company shall furnish to counsel to the Holders for such registration copies of
all documents proposed to be filed, which documents shall be subject to review by counsel to the Holders at the Holder’s expense,
and give the Holders participating in such registration an opportunity to comment on such documents and keep such Holders reasonably informed
as to the registration process;


 


(ii)             
furnish to each Holder participating in the registration, without charge, such number of copies of the Prospectus included
in such Registration Statement (including each preliminary Prospectus) and any supplement thereto (in each case including all exhibits
thereto and all documents incorporated by reference therein) and such other documents as such Holder may reasonably request, including
in order to facilitate the disposition of the Registrable Securities owned by such Holder;


 


(iii)            
use its reasonable best efforts to register or qualify such Registrable Securities under such other securities or blue sky
laws of such U.S. jurisdiction(s) or such U.S. self-regulatory bodies as any Holder participating in the registration reasonably requests
and do any and all other acts and things that may be necessary or reasonably advisable to enable such Holder to consummate the disposition
of such Holder’s Registrable Securities in such jurisdiction(s); provided, that the Company shall not be required to qualify
generally to do business, subject itself to taxation or consent to general service of process in any jurisdiction where it would not otherwise
be required to do so but for its obligations pursuant to this Section 2.2(a)(iii);


 






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(iv)             notwithstanding
any other provisions of this Agreement to the contrary, cause (A) any Registration Statement (as of the effective date of the
Registration Statement), any amendment thereof (as of the effective date thereof) or supplement thereto (as of its date),
(1) to comply in all material respects with the applicable requirements of the Securities Act and the rules and regulations of
the SEC and (2) not to contain any untrue statement of a material fact or omit to state a material fact required to be stated
therein or necessary in order to make the statements therein not misleading and (B) any related Prospectus, preliminary Prospectus
and any amendment thereof or supplement thereto (as of its date), (1) to comply in all material respects with the applicable
requirements of the Securities Act and the rules and regulations of the SEC, and (2) not to contain any untrue statement of a
material fact or omit to state a material fact required to be stated therein or necessary in order to make the statements therein,
in the light of the circumstances under which they were made, not misleading; provided, however, the Company shall have no
such obligations or liabilities with respect to any written information pertaining to a Holder and furnished to the Company by or on
behalf of such Holder specifically for inclusion therein; provided further, that each Holder of Registrable Securities,
upon receipt of any notice from the Company of any noncompliance event or material misstatement or omission of the kind described in
this Section 2.2(a)(iv), shall forthwith discontinue disposition of Registrable Securities pursuant to the Registration
Statement covering such Registrable Securities until such Holder is advised in writing by the Company that the use of the Prospectus
may be resumed and, if appropriate, is furnished with a supplemented or amended Prospectus as contemplated by this Section
2.2(a)(iv);


 


(v)              
as promptly as practicable (and in any event, within twenty-four (24) hours), notify the Holders: (A) when the Registration
Statement, any pre-effective amendment thereto, the Prospectus or any Prospectus supplement or any post-effective amendment thereto has
been filed with the SEC and when the Registration Statement or any post-effective amendment thereto has become effective, (B) of any oral
or written comments by the SEC or of any request by the SEC for amendments or supplements to the Registration Statement or the Prospectus
included therein or for any additional information regarding such Holder, (C) of the issuance by the SEC of any stop order suspending
the effectiveness of such Registration Statement or the initiation or threatening of any proceedings for that purpose and of any other
action, event or failure to act that would cause the Registration Statement not to remain effective, and (D) of the receipt by the Company
of any notification with respect to the suspension of the qualification or exemption from qualification of any Registrable Securities
for sale under the applicable securities or blue sky laws of any jurisdiction or the initiation of any proceeding for such purpose;


 


(vi)             in
the event of the issuance of any stop order suspending the effectiveness of a Registration Statement, any order suspending or
preventing the use of any related Prospectus or any suspension of the qualification or exemption from qualification of any
Registrable Securities for sale in any jurisdiction, use its reasonable best efforts to promptly obtain the withdrawal or lifting of
any such order or suspension, and each Holder of Registrable Securities, upon receipt of any notice from the Company of any event of
the kind described in this Section 2.2(a)(vi), shall forthwith discontinue disposition of Registrable Securities
pursuant to the Registration Statement covering such Registrable Securities until such Holder is advised in writing by the Company
that the use of the Prospectus may be resumed and is furnished with a supplemented or amended Prospectus, if applicable;


 






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(vii)           
not file or make any amendment to any Registration Statement with respect to any Registrable Securities, or any amendment
of or supplement to the Prospectus used in connection therewith, that refers to any Holder covered thereby by name or otherwise identifies
such Holder as the holder of any securities of the Company without the consent of such Holder (which consent shall not be unreasonably
withheld, conditioned or delayed), unless and to the extent such disclosure is required by law; provided, that (A) each Holder
shall furnish to the Company in writing such information regarding itself and the distribution proposed by it as the Company may reasonably
request for use in connection with a Registration Statement or Prospectus and (B) each Holder agrees to notify the Company as promptly
as practicable of any inaccuracy or change in information previously furnished to the Company by such Holder or of the occurrence of any
event that would cause the Prospectus included in such Registration Statement to contain an untrue statement of a material fact regarding
such Holder or the distribution of such Registrable Securities or to omit to state any material fact regarding such Holder or the distribution
of such Registrable Securities required to be stated therein or necessary to make the statements made therein not misleading in light
of the circumstances under which they were made and to furnish to the Company, as promptly as practicable, any additional information
required to correct and update the information previously furnished by such Holder such that such Prospectus shall not contain any untrue
statement of a material fact regarding such Holder or the distribution of such Registrable Securities or omit to state a material fact
regarding such Holder or the distribution of such Registrable Securities necessary to make the statements therein not misleading in light
of the circumstances under which they were made;


 


(viii)          
cause such Registrable Securities to be listed on each securities exchange on which the Common Stock is then listed or,
if the Common Stock is not then listed on any securities exchange, use its reasonable best efforts to cause such Registrable Securities
to be listed on a national securities exchange selected by the Company after consultation with the Holders participating in such registration;


 


(ix)            
provide a transfer agent and registrar (which may be the same Person) for all such Registrable Securities not later than
the effective date of such Registration Statement and, within a reasonable time prior to any proposed sale of Registrable Securities pursuant
to a Registration Statement, provide the transfer agent if reasonably required by the transfer agent, an opinion of counsel as to the
effectiveness of the Registration Statement, together with any other authorizations, certificates and directions required by the transfer
agent which authorize and direct the transfer agent to issue such Registrable Securities without legend upon sale by the Holder of such
Registrable Securities under the Registration Statement, subject to the provisions of Section 3.1;


 






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(x)              
 otherwise use its reasonable best efforts to comply with all applicable rules and regulations of the SEC, and make available
to its stockholders, as soon as reasonably practicable, an earnings statement (in a form that satisfies the provisions of Section 11(a)
of the Securities Act and Rule 158 under the Securities Act or any successor rule thereto) covering the period of at least 12 months beginning
with the first day of the Company’s first full fiscal quarter after the effective date of the applicable Registration Statement,
which requirement shall be deemed satisfied if the Company timely files complete and accurate information on Forms 10-K, 10-Q and 8-K
under the Exchange Act and otherwise complies with Rule 158 under the Securities Act or any successor rule thereto;


 


(xi)            
(A) furnish to each Holder all legal opinions of outside counsel to the Company required to be included in the Registration
Statement, which provision shall be satisfied by filing with the SEC any such opinion as an exhibit to the Registration Statement and
(B) obtain all consents of independent public accountants required to be included in the Registration Statement;


 


(xii)           
cooperate with the Holders of the Registrable Securities to facilitate the timely preparation and delivery of certificates
representing the Registrable Securities to be sold pursuant to such Registration Statement free of any restrictive legends and representing
such number of shares of Common Stock and registered in such names as the Holders of the Registrable Securities may reasonably request
a reasonable period of time prior to sales of Registrable Securities pursuant to such Registration Statement; provided, that the
Company may satisfy its obligations hereunder without issuing physical stock certificates through the use of The Depository Trust Company’s
Direct Registration System; and


 


(xiii)          
otherwise use its reasonable best efforts to take or cause to be taken all other actions necessary or reasonably advisable
to effect the registration of such Registrable Securities contemplated by this Agreement.


 


(b)               As
promptly as practicable after becoming aware of such event, the Company shall notify the Holders of the happening of any event (a
 “Suspension Event”), of which the Company has knowledge, as a result of which the Prospectus included in a
Registration Statement as then in effect includes an untrue statement of a material fact or omits to state a material fact required
to be stated therein or necessary to make the statements therein not misleading in light of the circumstances under which they were
made, and as promptly as practicable, the Company shall prepare and file with the SEC a supplement or amendment to the Registration
Statement to correct such untrue statement or omission, and deliver such number of copies of such supplement or amendment to the
Holders as the Holders may reasonably request so that, as thereafter delivered to the purchasers of such Registrable Securities,
such Prospectus will not contain any untrue statement of a material fact or omit to state any fact necessary to make the statements
therein not misleading in the light of the circumstances under which they were made; provided, however, that, for not more
than forty-five (45) consecutive days (or a total of not more than one hundred and twenty (120) Trading Days in any 12-month
period), the Company may delay or suspend the filing, effectiveness or use of a Registration Statement or Prospectus, to the extent
permitted by and in a manner not in violation of applicable securities laws, if the board of directors of the Company determines in
good faith, based on the advice of counsel, that (i) proceeding with the filing, effectiveness or use of such Registration Statement
or Prospectus would reasonably be expected to require the Company to disclose any information the disclosure of which would have a
material adverse effect on the Company and that the Company would not otherwise be required to disclose at such time or (ii) the
registration or offering proposed to be delayed or suspended would reasonably be expected to, if not delayed or suspended, have a
material adverse effect on any pending negotiation or plan of the Company to effect a merger, acquisition, disposition, financing,
reorganization, recapitalization or similar transaction, in each case that, if consummated, would be material to the Company.


 






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(c)              
Upon a Suspension Event, the Company shall promptly give written notice (a “Suspension Notice”)
to the Holders to suspend sales of the affected Registrable Securities, and such notice shall state that such suspension shall continue
only for so long as the Suspension Event or its effect is continuing and the Company is pursuing with reasonable diligence the completion
of the matter giving rise to the Suspension Event or otherwise taking all reasonable steps to terminate suspension of the effectiveness
or use of the Registration Statement. In no event shall the Company, without the prior written consent of the Holders, disclose to the
Holders any of the facts or circumstances giving rise to the Suspension Event. The Holders shall not effect any sales of the Registrable
Securities pursuant to the Registration Statement (or such filings), at any time after they have received a Suspension Notice and prior
to receipt of an End of Suspension Notice. The Holders may resume effecting sales of the Registrable Securities under the Registration
Statement (or such filings), following further notice to such effect (an “End of Suspension Notice”) from the
Company. This End of Suspension Notice shall be given by the Company to the Holders in the manner described above promptly following the
conclusion of any Suspension Event and its effect. For the avoidance of doubt, a Suspension Notice shall not affect or otherwise limit
sales of affected Registrable Securities under Rule 144 or otherwise outside of the Registration Statement;


 


(d)              
Notwithstanding any provision herein to the contrary, if the Company gives a Suspension Notice pursuant to Section 2.2(c)
with respect to any Registration Statement, the Company shall extend the period during which the Registration Statement shall be maintained
effective under this Agreement by the number of days during the period from the date of the giving of the Suspension Notice to and including
the date when the Holders shall have received the End of Suspension Notice and copies of the supplemented or amended Prospectus necessary
to resume sales.


 


(e)              
Notwithstanding anything to the contrary contained in this Agreement, the Company shall not be required to include Registrable
Securities in any Registration Statement unless the Holder owning the Registrable Securities to be registered on the Registration Statement,
following reasonable advance written request by the Company, furnishes to the Company, at least ten Business Days prior to the scheduled
filing date of the Registration Statement, an executed stockholder questionnaire in the form attached hereto as Exhibit A.


 






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2.3             
 Registration Expenses


 


(a)              
The Company shall bear all Registration Expenses.


 


(b)              
The obligation of the Company to bear and pay the Registration Expenses shall apply irrespective of whether a registration
becomes effective or is withdrawn or suspended; provided, that the Registration Expenses for any Registration Statement withdrawn
solely at the request of one or more Holder(s) (unless withdrawn following commencement of a Suspension Event) shall be borne by such
Holder(s).


 


2.4             
Indemnification.


 


(a)              
The Company shall, to the fullest extent permitted by law, indemnify and hold harmless each Holder and any Person who is
or might be deemed to be a “controlling person” of such Holder (within the meaning of the Securities Act or the Exchange Act)
(each such Person, a “Controlling Person”), as well as their respective direct and indirect general and limited
partners, advisory board members, directors, officers, trustees, managers, members, employees, agents, Affiliates and shareholders, and
each other Person, if any, who acts on behalf of or controls any such Holder or Controlling Person (collectively, the “Holder
Indemnified Parties”) from and against any losses, claims, damages, liabilities or expenses, joint or several, or any actions
in respect thereof to which each Holder Indemnified Party may become subject under the Securities Act, the Exchange Act, any state blue
sky securities laws, insofar as such losses, claims, damages, liabilities, expenses or actions arise out of or are based upon (i) any
untrue statement or alleged untrue statement of a material fact contained in or incorporated by reference in any Registration Statement
or in any amendment thereof, in each case at the time such became effective under the Securities Act, (ii) the omission or alleged omission
to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading or (iii) any
violation or alleged violation by the Company of the Securities Act or any other similar federal or state securities laws or any rule
or regulation promulgated thereunder applicable to the Company and relating to any action or inaction required of the Company in connection
with any registration of securities, and the Company shall reimburse, as incurred, the Holder Indemnified Parties for any reasonable and
documented legal or other expenses reasonably incurred by them in connection with investigating, defending or settling any such loss,
claim, damage, liability, expense or action in respect thereof; provided, however, that the Company shall not be liable in any
such case to the extent that such loss, claim, damage, liability, expense or action arises out of or is based upon any untrue statement
or omission made or incorporated by reference in any such Registration Statement, any Prospectus or in any amendment thereof or supplement
thereto in reliance upon and in conformity with written information pertaining to a Holder and furnished to the Company by or on behalf
of such Holder Indemnified Party specifically for inclusion therein; and provided further, however, that this indemnity agreement
will be in addition to any liability that the Company may otherwise have to such Holder Indemnified Party. Such indemnity shall remain
in full force and effect regardless of any investigation made by or on behalf of any Holder Indemnified Parties and shall survive the
transfer of the Registrable Securities by any Holder.


 






    12


     


    

 


(b)              
 In connection with any registration in which a Holder of Registrable Securities is participating, each such Holder shall
furnish to the Company in writing such information as the Company reasonably requests for use in connection with any such Registration
Statement or Prospectus and shall, severally and not jointly, to the fullest extent permitted by law, indemnify and hold harmless the
Company, its directors and officers, employees, agents and any Person who is or might be deemed to be a Controlling Person (a “Company
Indemnified Party”) from and against any losses, claims, damages, liabilities or expenses or any actions in respect thereof,
to which a Company Indemnified Party may become subject under the Securities Act, the Exchange Act, any state blue sky securities laws,
any equivalent non-U.S. securities laws or otherwise, insofar as such losses, claims, damages, liabilities or actions arise out of or
are based upon (i) any untrue statement or alleged untrue statement of a material fact contained in the Registration Statement or in any
amendment thereof, in each case at the time such became effective under the Securities Act, or in any Prospectus or in any amendment thereof
or supplement thereto, or (ii) the omission or alleged omission to state therein a material fact required to be stated therein or necessary
to make the statements therein (in the case of any Prospectus, in the light of the circumstances under which they were made) not misleading,
but in each of clauses (i) and (ii), only to the extent that the untrue statement or omission or alleged untrue statement or omission
was made in reliance upon and in conformity with written information pertaining to such Holder and furnished to the Company by or on behalf
of such Holder specifically for inclusion therein, and, subject to the limitation immediately preceding this clause, shall reimburse,
as incurred, the Company Indemnified Parties for any legal or other expenses reasonably incurred by them in connection with investigating,
defending or settling any such loss, claim, damage, liability, expense or action in respect thereof. Such indemnity shall remain in full
force and effect regardless of any investigation made by or on behalf of such Holder, or any such director, officer, employees, Affiliates
and agents and shall survive the transfer of such Registrable Securities by such Holder, and such Holder shall reimburse the Company,
and each such director, officer, employees, Affiliates and agents for any legal or other expenses reasonably incurred by them in connection
with investigating, defending, or settling any such loss, claim, damage, liability, action, or proceeding; provided, however, that
the indemnity amount contained in this Section 2.4(b) shall in no event exceed the net proceeds actually received by such Holder
in the sale of Registrable Securities to which such Registration Statement or Prospectus relates. Such indemnity shall remain in full
force and effect, regardless of any investigation made by or on behalf of the Company or any such director, officer, employees, Affiliates
and agents and shall survive the transfer by a Holder of such Registrable Securities.


 






    13


     


    

 


(c)               Promptly
after receipt by a Holder Indemnified Party or a Company Indemnified Party (each, an “Indemnified Party”)
of notice of the commencement of any action or proceeding (including a governmental investigation), such Indemnified Party will, if
a claim in respect thereof is to be made against the indemnifying party under this Section 2.4, notify the indemnifying party
of the commencement thereof; provided, that the omission to so notify the indemnifying party will not relieve the
indemnifying party from liability under Sections 2.4(a) or 2.4(b) unless and to the extent it did not otherwise learn
of such action and the indemnifying party has been materially prejudiced by such failure. In case any such action is brought against
any Indemnified Party, and it notifies the indemnifying party of the commencement thereof, the indemnifying party will be entitled
to participate therein and, to the extent that it may wish, jointly with any other indemnifying party similarly notified, to assume
the defense thereof at the indemnifying party’s expense, with counsel reasonably satisfactory to such Indemnified Party (who
shall not, except with the consent of the Indemnified Party, be counsel to the indemnifying party); provided, that any
Indemnified Party shall continue to be entitled to participate in the defense of such claim or action, with counsel of its own
choice, but the indemnifying party shall not be obligated to reimburse such Indemnified Party for any fees, costs and expenses
subsequently incurred by the Indemnified Party in connection with such defense unless (i) the indemnifying party has agreed in
writing to pay such fees, costs and expenses, (ii) the indemnifying party has failed to assume the defense of such claim or action
within a reasonable time after receipt of notice of such claim or action, (iii) having assumed the defense of such claim or action,
the indemnifying party fails to employ counsel reasonably acceptable to the Indemnified Party or to pursue the defense of such claim
or action in a reasonably vigorous manner, (iv) the use of counsel chosen by the indemnifying party to represent the Indemnified
Party would present such counsel with a conflict of interest or (v) the Indemnified Party has reasonably concluded that there may be
one or more legal or equitable defenses available to it and/or other any other Indemnified Party which are different from or
additional to those available to the indemnifying party. In no event shall the indemnifying party be liable for the fees and
expenses of more than one counsel (together with appropriate local counsel) at any time for any Indemnified Party in connection with
any one action or separate but substantially similar or related actions arising in the same jurisdiction out of the same general
allegations or circumstances. No indemnifying party shall, without the prior written consent of the Indemnified Party (which consent
shall not be unreasonably withheld, conditioned or delayed), effect any settlement of any pending or threatened action in respect of
which any Indemnified Party is or could have been a party and indemnity could have been sought hereunder by such Indemnified Party
unless such settlement (i) includes an unconditional release of such Indemnified Party from all liability on any claims that are the
subject matter of such action, in form and substance reasonably satisfactory to such Indemnified Party, and (ii) does not include a
statement as to or an admission of fault, culpability or a failure to act by or on behalf of any Indemnified Party.


 









    14


     


    

 


(d)               If
the indemnification provided for in this Section 2.4 is unavailable or insufficient to hold harmless an Indemnified Party
under Sections 2.4(a) or 2.4(b), then each indemnifying party shall contribute to the amount paid or payable by such
Indemnified Party as a result of the losses, claims, damages or liabilities (or actions in respect thereof) referred to in Sections
2.4(a) or 2.4(b) in such proportion as is appropriate to reflect the relative fault of the indemnifying party or parties
on the one hand and the Indemnified Party on the other in connection with the statements or omissions that resulted in such losses,
claims, damages or liabilities (or actions in respect thereof) as well as any other relevant equitable considerations. The relative
fault of the parties shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of a
material fact or the omission or alleged omission to state a material fact relates to information supplied by the Company on the one
hand or a Holder or Holder Indemnified Party, as the case may be, on the other, and the parties’ relative intent, knowledge,
access to information and opportunity to correct or prevent such statement or omission. The amount paid by an Indemnified Party as a
result of the losses, claims, damages or liabilities referred to in the first sentence of this Section 2.4 shall be deemed to
include any legal or other expenses reasonably incurred by such Indemnified Party in connection with investigating or defending any
action or claim that is the subject of this Section 2.4(c). The parties agree that it would not be just and equitable if
contributions were determined by pro rata allocation (even if a Holder was treated as one Person for such purpose) or any
other method of allocation that does not take account of the equitable considerations referred to above. Notwithstanding any other
provision of this Section 2.4(c), no Holder shall be required to contribute any amount in excess of the amount by which the
net proceeds received by such Holder from the sale of the Registrable Securities pursuant to the Registration Statement exceeds the
amount of damages that such Holder has otherwise been required to pay by reason of such untrue or alleged untrue statement or
omission or alleged omission. No person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the
Securities Act) shall be entitled to contribution from any person who was not guilty of such fraudulent misrepresentation.


 


(e)              
The agreements contained in this Section 2.4 shall survive the sale of the Registrable Securities pursuant to the
Registration Statement and shall remain in full force and effect, regardless of any termination or cancellation of this Agreement or any
investigation made by or on behalf of any Indemnified Party.


 


Article
III

Transfer Restrictions


 


3.1             
Transfer Restrictions. Each Holder acknowledges and agrees that the following legend shall be imprinted on any certificate
or book-entry security entitlement evidencing any of the Registrable Securities to the extent that at the time of issuance such Registrable
Securities are not covered by an effective Registration Statement:


 


THE SECURITIES REPRESENTED HEREBY
HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER THE SECURITIES LAWS
OF ANY STATE. THESE SECURITIES ARE SUBJECT TO RESTRICTIONS ON TRANSFERABILITY AND RESALE AND MAY NOT BE TRANSFERRED OR RESOLD EXCEPT AS
PERMITTED UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS, PURSUANT TO REGISTRATION OR EXEMPTION THEREFROM. INVESTORS SHOULD BE AWARE
THAT THEY MAY BE REQUIRED TO BEAR THE FINANCIAL RISKS OF THIS INVESTMENT FOR AN INDEFINITE PERIOD OF TIME. THE ISSUER OF THESE SECURITIES
MAY REQUIRE AN OPINION OF COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE ISSUER TO THE EFFECT THAT ANY PROPOSED TRANSFER OR RESALE
IS IN COMPLIANCE WITH THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS.


 






    15


     


    

 


This legend shall be removed by the Company from
any certificate or book-entry security entitlement evidencing the Registrable Securities upon delivery by the holder thereof to the Company
of a written request to that effect if at the time of such written request (a) a registration statement under the Securities Act
is at that time in effect with respect to the legended security, or (b) the legended security can be transferred in a transaction in compliance
with Rule 144, and, in the case of (b), upon the request and in the reasonable discretion of the Company’s transfer agent, the holder
of such Registrable Securities executes and delivers a representation letter that includes customary representations regarding the holding
requirements and whether such holder is an “affiliate” for purposes of Rule 144. The Company represents and warrants to the
Purchasers that the Company is not currently a shell company (as defined in Rule 405 promulgated under the Securities Act).


 


3.2             
Rule 144 Compliance. With a view to making available to the Holders of Registrable Securities the benefits of Rule
144 and any other rule or regulation of the SEC that may at any time permit a Holder to sell securities of the Company to the public without
registration until such date on which the Holders no longer hold any Registrable Securities, the Company shall:


 


(a)              
make and keep public information available, as those terms are understood and defined in Rule 144;


 


(b)              
use reasonable best efforts to file with the SEC in a timely manner all reports and other documents required of the Company
under the Securities Act and the Exchange Act; and


 


(c)              
furnish to any Holder of Registrable Securities, promptly upon request, a written statement by the Company as to its compliance
with the reporting requirements of Rule 144 and of the Securities Act and the Exchange Act.


 


Article
IV

Miscellaneous.


 


4.1             
Remedies; Specific Performance. In the event of a breach or a threatened breach by any party to this Agreement of
its obligations under this Agreement, any party injured or to be injured by such breach shall be entitled to specific performance of its
rights under this Agreement or to injunctive relief, in addition to being entitled to exercise all rights provided in this Agreement and
granted by law, it being agreed by the parties that the remedy at law, including monetary damages, for breach of any such provision will
be inadequate compensation for any loss and that any defense or objection in any action for specific performance or injunctive relief
for which a remedy at law would be adequate is hereby waived.


 


4.2             
No Waivers. No failure or delay by any party in exercising any right, power or privilege hereunder shall operate
as a waiver thereof nor shall any single or partial exercise thereof preclude any other or further exercise thereof or the exercise of
any other right, power or privilege.


 






    16


     


    

 


4.3             
Further Assurances. Each party shall do and perform, or cause to be done and performed, all such further acts and
things, and shall execute and deliver all such other agreements, certificates, instruments and documents, as any other party may reasonably
request in order to carry out the intent and accomplish the purposes of this Agreement and the consummation of the transactions contemplated
hereby.


 


4.4             
Notices. All notices and other communications provided for herein shall be in writing and shall be delivered by hand
or overnight courier service, mailed by certified or registered mail or sent by facsimile or e-mail as follows:


 


If to the Company:


 


BioXcel Therapeutics, Inc.


555 Long Wharf Drive


New Haven, CT


Attn: Chief Financial Officer

Email: [     ]


 


With a copy (which shall not constitute notice) to:


 


Cooley LLP


101 California Street, 5th Floor


San Francisco, CA 94111-5800


Attention: Mischi a Marca


Email: [      ]


 


If to a Purchaser: To the address set forth opposite
such Purchaser’s name on Schedule A hereto, or to such other address and/or e-mail address and/or to the attention of such
other person as the recipient party has specified by written notice given to each other party at least five days prior to the effectiveness
of such change.


 


With a copy (which shall not constitute notice) to:


 


Sullivan & Cromwell LLP


125 Broad Street


New York, NY 10004


E-mail: [      ]


Attn: Ari Blaut


 






    17


     


    

 


Notices or communications sent by hand or
overnight courier service, or mailed by certified or registered mail, shall be deemed to have been given when received, notices or
communications sent by facsimile shall be deemed to have been given when sent (except that, if not given during normal business
hours for the recipient, such notice or communication shall be deemed to have been sent at the opening of business on the next
Business Day for the recipient) and notices or communications sent by e-mail shall be deemed received upon the sender’s
receipt of an acknowledgement from the intended recipient (such as by the “return receipt requested” function, as
available, return e-mail or other written acknowledgement) (except that, if not given during the normal business hours of the
recipient, such notice or communication shall be deemed to have been sent at the opening of business on the next Business Day for
the recipient).


 


4.5             
Headings. Section headings herein are included for convenience of reference only and shall not constitute a part
hereof for any other purpose or be given any substantive effect.


 


4.6             
Counterparts. This Agreement may be executed in counterparts (and by different parties hereto in different counterparts),
each of which shall constitute an original, but all of which when taken together shall constitute a single contract. Delivery of an executed
counterpart of a signature page of this Agreement by facsimile or in electronic (i.e., “pdf” or “tif”) format
shall be effective as delivery of a manually executed counterpart of this Agreement.


 


4.7             
Governing Law; Disputes.


 


(a)              
Governing Law. This Agreement and any claims, controversy, dispute or cause of action (whether in contract or tort
or otherwise) based upon, arising out of or relating to this Agreement and the transactions contemplated hereby shall be governed by,
and construed in accordance with, the law of the State of New York.


 


(b)              
Jurisdiction. Each party hereto hereby irremovably and unconditionally agrees that it will not commence any action,
litigation or proceeding of any kind or description, whether in law or equity, whether in contract or tort or otherwise, against such
other party in any way relating to this Agreement or the transactions relating hereto or thereto, in any forum other than the courts of
the State of New York sitting in New York County, and of the United States District Court of the Southern District of New York, and any
appellate court from any thereof, and each of the parties hereto irrevocably and unconditionally submits to the jurisdiction of such courts
and agrees that all claims in respect of any such action, litigation or proceeding may be heard and determined in such New York State
court or, to the fullest extent permitted by applicable Law, in such federal court. Each of the parties hereto agrees that a final judgment
in any such action, litigation or proceeding shall be conclusive and may be enforced in other jurisdictions by suit on the judgment or
in any other manner provided by law.


 


(c)               Waiver
of Venue. Each party hereto irrevocably waives to the fullest extent permitted by law any objection that it may now or hereafter
have to the laying of the venue of any suit, action or proceeding arising out of or relating to this Agreement and hereby further
irrevocably waives to the fullest extent permitted by law any claim that any such suit, action or proceeding brought in any such
court has been brought in an inconvenient forum. A final judgment (in respect of which time for all appeals has elapsed) in any such
suit, action or proceeding shall be conclusive and may be enforced in any court to the jurisdiction of which such party is or may be
subject, by suit upon judgment.


 






    18


     


    

 


(d)              
Waiver of Jury Trial. EACH PARTY HERETO HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE
LAW, ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY IN ANY LEGAL PROCEEDING DIRECTLY OR INDIRECTLY ARISING OUT OF OR RELATING TO THIS AGREEMENT
OR THE TRANSACTIONS CONTEMPLATED HEREBY (WHETHER BASED ON CONTRACT, TORT OR ANY OTHER THEORY). EACH PARTY HERETO (A) CERTIFIES THAT NO
REPRESENTATIVE, AGENT OR ATTORNEY OF ANY OTHER PERSON HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH OTHER PERSON WOULD NOT, IN THE
EVENT OF LITIGATION, SEEK TO ENFORCE THE FOREGOING WAIVER AND (B) ACKNOWLEDGES THAT IT AND THE OTHER PARTIES HERETO HAVE BEEN INDUCED
TO ENTER INTO THIS AGREEMENT BY, AMONG OTHER THINGS, THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION 4.7.


 


(e)              
Service of Process. Each party hereto irrevocably consents to service of process in the manner provided for notices
in Section 4.4.


 


4.8             
Successors and Assigns. This Agreement and the rights and obligations evidenced hereby shall be binding upon and
inure to the benefit of the parties hereto and their respective the successors and permitted assigns. Neither this Agreement nor any right,
benefit, remedy, obligation or liability arising hereunder may be assigned by any party without the prior written consent of the other
parties, and any attempted assignment without such consent shall be null and void and of no effect; provided that that, (a) the
rights (and related obligations and liabilities) offered a Holder pursuant to this Agreement shall be assignable (in whole or in part)
by such Holder to any transferee of such Holder’s Registrable Securities or Warrants exercisable for Registrable Securities and
(b) any such assignment shall be effected hereunder only by giving written notice thereof from both the transferor and the transferee
to the Company and the transferee’s execution and delivery to the Company of an executed counterpart to this Agreement.


 


4.9             
Amendments. No provision of this Agreement may be amended, waived or modified other than by an instrument in writing
signed by the Company and Holders representing at least fifty percent (50%) (by number) of the Registrable Securities then held by the
Holders.


 


4.10           
Severability. Any provision of this Agreement held to be invalid, illegal or unenforceable in any jurisdiction shall,
as to such jurisdiction, be ineffective to the extent of such invalidity, illegality or unenforceability without affecting the validity,
legality and enforceability of the remaining provisions hereof, and the invalidity of a particular provision in a particular jurisdiction
shall not invalidate such provision in any other jurisdiction.


 






    19


     


    

 


4.11           
Termination. This Agreement shall terminate with respect to any Holder upon such time as such Holder ceases to hold
or beneficially own any remaining Registrable Securities or upon the dissolution, liquidation or winding up of the Company or a Change
of Control; provided that Section 2.3, Section 2.4 of this Agreement and this Article IV shall survive such
termination.


 


4.12           
No Third Party Beneficiaries. This Agreement is intended for the sole benefit of the parties hereto and their respective
permitted successors and assigns and transferees, and is not for the benefit of, nor may any provision hereof be enforced by, any other
person; provided, however, that the parties hereto hereby acknowledge that the Persons set forth in Section 2.4 shall be
express third-party beneficiaries of the obligations of the parties hereto set forth in Section 2.4.


 


4.13           
Language; Currency. This Agreement has been prepared in the English language and the English language shall control
its interpretation. In addition, all notices required or permitted to be given hereunder, and all written, electronic, oral or other communications
between the parties regarding this Agreement, shall be in the English language. All references to “$” contained in this Agreement
shall refer to United States Dollars unless otherwise stated.


 


[The remainder of this page intentionally
left blank]


 






    20


     


    

 



 


IN WITNESS WHEREOF, the parties hereto have
duly executed this Registration Rights Agreement as of the date first written above.


 


	 	THE COMPANY:
	 	 
	 	BioXcel Therapeutics, Inc.
	 	a Delaware Corporation
	 	 
	 	By:	/s/ Vimal Mehta
	 	 	Name:	Vimal Mehta
	 	 	Title:	Chief Executive Officer


 






     


     


    

 


	 	PURCHASERS:
	 	 
	 	OAKTREE-TCDRS STRATEGIC CREDIT, LLC  
	 	 	 
	 	By: 	Oaktree Capital Management, L.P.
	 	Its:	Manager
	 	 
	 	By:	/s/ Jessica Dombroff
	 	 	Name:	Jessica Dombroff
	 	 	Title:	Vice President
	 	 	 	 
	 	By:	/s/ Kendall Bass
	 	 	Name:	Kendall Bass
	 	 	Title:	Vice President





 






     


     


    

 


	 	OAKTREE-FORREST MULTI-STRATEGY, LLC  
	 	 
	 	By:	 Oaktree Capital Management, L.P.
	 	Its:	Manager
	 	 
	 	By:	/s/ Jessica Dombroff
	 	 	Name:	Jessica Dombroff
	 	 	Title:	Vice President
	 	 	 	 
	 	By:	/s/ Kendall Bass
	 	 	Name:	Kendall Bass
	 	 	Title:	Vice President




 






     


     


    

 


	 	OAKTREE-TBMR STRATEGIC CREDIT FUND C, LLC  
	 	 
	 	By: 	Oaktree Capital Management, L.P.
	 	Its:	Manager
	 	 
	 	By:	/s/ Jessica Dombroff
	 	 	Name:	Jessica Dombroff
	 	 	Title:	Vice President
	 	 	 	 
	 	By:	/s/ Kendall Bass
	 	 	Name:	Kendall Bass
	 	 	Title:	Vice President




 






     


     


    

 


	 	OAKTREE-TBMR STRATEGIC CREDIT FUND F, LLC  
	 	 
	 	By:	 Oaktree Capital Management, L.P.
	 	Its:	Manager
	 	 
	 	By:	/s/ Jessica Dombroff
	 	 	Name:	Jessica Dombroff
	 	 	Title:	Vice President
	 	 	 	 
	 	By:	/s/ Kendall Bass
	 	 	Name:	Kendall Bass
	 	 	Title:	Vice President




 






     


     


    

 


	 	OAKTREE-FORREST MULTI-STRATEGY, LLC  
	 	 
	 	By: 	Oaktree Capital Management, L.P.
	 	Its:	Manager
	 	 
	 	By:	/s/ Jessica Dombroff
	 	 	Name:	Jessica Dombroff
	 	 	Title:	Vice President
	 	 	 	 
	 	By:	/s/ Kendall Bass
	 	 	Name:	Kendall Bass
	 	 	Title:	Vice President




 



     


     


    




 


	 	OAKTREE-TBMR STRATEGIC CREDIT FUND C, LLC  
	 	 
	 	By: 	Oaktree Capital Management, L.P.
	 	Its:	Manager
	 	 
	 	By:	/s/ Jessica Dombroff
	 	 	Name:	Jessica Dombroff
	 	 	Title:	Vice President
	 	 	 	 
	 	By:	/s/ Kendall Bass
	 	 	Name:	Kendall Bass
	 	 	Title:	Vice President





 






     


     


    

 


	 	OAKTREE-TBMR STRATEGIC CREDIT FUND F, LLC  
	 	 
	 	By:	 Oaktree Capital Management, L.P.
	 	Its:	Manager
	 	 
	 	By:	/s/ Jessica Dombroff
	 	 	Name:	Jessica Dombroff
	 	 	Title:	Vice President
	 	 	 	 
	 	By:	/s/ Kendall Bass
	 	 	Name:	Kendall Bass
	 	 	Title:	Vice President





 






     


     


    

 


 


	 	OAKTREE-TBMR STRATEGIC CREDIT FUND G, LLC  
	 	 
	 	By:	 Oaktree Capital Management, L.P.
	 	Its:	Manager
	 	 
	 	By:	/s/ Jessica Dombroff
	 	 	Name:	Jessica Dombroff
	 	 	Title:	Vice President
	 	 	 	 
	 	By:	/s/ Kendall Bass
	 	 	Name:	Kendall Bass
	 	 	Title:	Vice President





 






     


     


    

 


	 	OAKTREE-TSE 16 STRATEGIC CREDIT, LLC
	 	 	 
	 	By:	 Oaktree Capital Management, L.P.
	 	Its:	Manager
	 	 
	 	By:	/s/ Jessica Dombroff
	 	 	Name:	Jessica Dombroff
	 	 	Title:	Vice President
	 	 	 	 
	 	By:	/s/ Kendall Bass
	 	 	Name:	Kendall Bass
	 	 	Title:	Vice President





 




     


     


    



 


	 	INPRS STRATEGIC CREDIT HOLDINGS, LLC  
	 	 
	 	By:	Oaktree Capital Management, L.P.
	 	Its:	Manager
	 	 	 
	 	By:	/s/ Jessica Dombroff
	 	 	Name:	Jessica Dombroff
	 	 	Title:	Vice President
	 	 	 	 
	 	By:	/s/ Kendall Bass
	 	 	Name:	Kendall Bass
	 	 	Title:	Vice President



 






     


     


    

 


	 	OAKTREE STRATEGIC INCOME II, INC.
	 	 
	 	By:	Oaktree Fund Advisors, LLC
	 	Its:	Investment Advisor
	 	 	 
	 	By:	/s/ Jessica Dombroff
	 	 	Name:	Jessica Dombroff
	 	 	Title:	Vice President
	 	 	 	 
	 	By:	/s/ Kendall Bass
	 	 	Name:	Kendall Bass
	 	 	Title:	Vice President


 






     


     


    

 


	 	OAKTREE SPECIALTY LENDING CORPORATION
	 	 
	 	By:	Oaktree Fund Advisors, LLC
	 	Its:	Investment Advisor
	 	 	 
	 	By:	/s/ Jessica Dombroff
	 	 	Name:	Jessica Dombroff
	 	 	Title:	Vice President
	 	 	 	 
	 	By:	/s/ Kendall Bass
	 	 	Name:	Kendall Bass
	 	 	Title:	Vice President


 






     


     


    

 





	 	OAKTREE STRATEGIC CREDIT FUND
	 	 
	 	By:	Oaktree Fund Advisors, LLC
	 	Its:	Investment Advisor
	 	 	 
	 	By:	/s/ Jessica Dombroff
	 	 	Name:	Jessica Dombroff
	 	 	Title:	Vice President
	 	 	 	 
	 	By:	/s/ Kendall Bass
	 	 	Name:	Kendall Bass
	 	 	Title:	Vice President


 






     


     


    

 





	 	OAKTREE GCP FUND DELAWARE HOLDINGS, L.P.
	 	 
	 	By:	Oaktree Global Credit Plus Fund GP, L.P.
	 	Its:	General Partner
	 	 	 
	 	By:	Oaktree Global Credit Plus Fund GP Ltd.
	 	Its:	General Partner
	 	 	 
	 	By:	Oaktree Capital Management, L.P.
	 	Its:	Director
	 	 	 
	 	By:	/s/ Jessica Dombroff
	 	 	Name:	Jessica Dombroff
	 	 	Title:	Vice President
	 	 	 	 
	 	By:	/s/ Kendall Bass
	 	 	Name:	Kendall Bass
	 	 	Title:	Vice President


 






     


     


    

 





	 	OAKTREE DIVERSIFIED INCOME FUND INC.
	 	 
	 	By:	Oaktree Fund Advisors, LLC
	 	Its:	Investment Advisor
	 	 	 
	 	By:	/s/ Jessica Dombroff
	 	 	Name:	Jessica Dombroff
	 	 	Title:	Vice President
	 	 	 	 
	 	By:	/s/ Kendall Bass
	 	 	Name:	Kendall Bass
	 	 	Title:	Vice President


 






     


     


    

 





	 	OAKTREE AZ STRATEGIC LENDING FUND, L.P.
	 	 
	 	By:	Oaktree AZ Strategic Lending Fund GP, L.P.
	 	Its:	General Partner
	 	 	 
	 	By:	Oaktree Fund GP IIA, LLC
	 	Its:	General Partner
	 	 	 
	 	By:	Oaktree Fund GP II, L.P.
	 	Its:	Managing Member
	 	 	 
	 	By:	/s/ Jessica Dombroff
	 	 	Name:	Jessica Dombroff
	 	 	Title:	Authorized Signatory
	 	 	 	 
	 	By:	/s/ Kendall Bass
	 	 	Name:	Kendall Bass
	 	 	Title:	Authorized Signatory


 






     


     


    

 





	 	OAKTREE LOAN ACQUISITION FUND, L.P.
	 	 	 
	 	By:	Oaktree Fund GP IIA, LLC
	 	Its:	General Partner
	 	 	 
	 	By:	Oaktree Fund GP II, L.P.
	 	Its:	Managing Member
	 	 	 
	 	By:	/s/ Jessica Dombroff
	 	 	Name:	Jessica Dombroff
	 	 	Title:	Authorized Signatory
	 	 	 	 
	 	By:	/s/ Kendall Bass
	 	 	Name:	Kendall Bass
	 	 	Title:	Authorized Signatory


 






     


     


    

 





	 	OAKTREE LSL FUND DELAWARE HOLDINGS EURRC, L.P.
	 	 
	 	By:	Oaktree Life Sciences Lending Fund, L.P.
	 	Its:	General Partner
	 	 	 
	 	By:	Oaktree Life Sciences Lending Fund GP Ltd.
	 	Its:	General Partner
	 	 	 
	 	By:	Oaktree Capital Management, L.P.
	 	Its:	Director
	 	 	 
	 	By:	/s/ Jessica Dombroff
	 	 	Name:	Jessica Dombroff
	 	 	Title:	Vice President
	 	 	 	 
	 	By:	/s/ Kendall Bass
	 	 	Name:	Kendall Bass
	 	 	Title:	Vice President


 






     


     


    

 


	 	PURCHASER:
	 	 
	 	Q BOOST HOLDING LLC
	 	 
	 	By:	/s/ Ahmed Nasser Al-Abdulghani
	 	 	Name:	Ahmed Nasser Al-Abdulghani
	 	 	Title:	Director


 









     



     


    

 


Exhibit A

Form of Selling Stockholder Questionnaire

BIOXCEL THERAPEUTICS, INC.


 


SELLING STOCKHOLDER
NOTICE AND QUESTIONNAIRE


 


The undersigned holder of Registrable Securities
issued by BioXcel Therapeutics, Inc. (the “Company”) understands that the Company intends to file with the Securities
and Exchange Commission a registration statement on Form S-3 (the “Registration Statement”) for the registration
and the resale under Rule 415 of the Securities Act of 1933, as amended (the “Securities Act”), of the Registrable
Securities in accordance with the terms of the Registration Rights Agreement, dated April 19, 2022, by and among the Company and the Purchasers
party thereto (the “Registration Rights Agreement”). All capitalized terms not otherwise defined herein shall
have the meanings ascribed thereto in the Registration Rights Agreement.


 


In order to sell or otherwise dispose of any Registrable
Securities pursuant to the Registration Statement, a holder of Registrable Securities generally will be required to be named as a selling
stockholder in the related prospectus or a supplement thereto (as so supplemented, the “Prospectus”), deliver
the Prospectus to purchasers of Registrable Securities (including pursuant to Rule 172 under the Securities Act) and be bound by the provisions
of the Registration Rights Agreement (including certain indemnification provisions, as described therein). Holders must complete and deliver
this notice and questionnaire (“Notice and Questionnaire”) in order to be named as selling stockholders in the
Prospectus. Certain legal consequences arise from being named as a selling stockholder in the Registration Statement and the Prospectus.
Holders of Registrable Securities are advised to consult their own securities law counsel regarding the consequences of being named or
not named as a selling stockholder in the Registration Statement and the Prospectus.


 


NOTICE


 


The undersigned holder (the “Selling
Stockholder”) of Registrable Securities hereby gives notice to the Company of its intention to sell or otherwise dispose
of Registrable Securities owned by it and listed below in Part III(b) pursuant to the Registration Statement. The undersigned, by signing
and returning this Notice and Questionnaire, understands and agrees that it will be bound by the terms and conditions of this Notice and
Questionnaire and the Registration Rights Agreement.


 


The undersigned hereby provides the following information
to the Company and represents and warrants that such information is materially accurate and complete:


 






     



     


    

 


QUESTIONNAIRE


 


PART I. Name:


 


	 	(a)	Full legal name of the Selling Stockholder:
	 	 	 
	 	 	 
	 	 	 
	 	(b)	Full legal name of the registered holder (if not the same as Part I(a) above) through which the Registrable Securities listed in Part III below are held:
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	 	(c)	Full legal name of any natural control person (which means a natural person who directly or indirectly alone or with others has power to vote or dispose of the Registrable Securities listed in Part III below):
	 	 	 
	 	 	 


PART II. Notices to Selling Stockholder:


 


	 	(a)	Address:
	 	 	 
	 	 	 
	 	 	 
	 	(b)	Telephone:
	 	 	 
	 	 	 
	 	 	 
	 	(c)	Fax:
	 	 	 
	 	 	 
	 	 	 
	 	(d)	Contact person:
	 	 	 
	 	 	 
	 	 	 
	 	(e)	E-mail address of contact person:
	 	 	 
	 	 	 


 






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PART III. Beneficial Ownership of Registrable Securities:


 


	 	(a)	Type and number of Registrable Securities beneficially owned:
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	 	(b)	Number of shares of Common Stock to be registered for resale pursuant to this Notice and Questionnaire:
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	 	 	 


PART IV. Broker-Dealer Status:


 


	 	(a)	Are you a broker-dealer?
	 	 	 
	 	 	Yes o   No o
	 	 	 
	 	(b)	If you answered “yes” to Part IV(a) above, did you receive your Registrable Securities as compensation for investment banking services provided to the Company?
	 	 	 
	 	 	Yes o   No o
	 	 	 
	 	 	Note: If you answered “no”, the SEC’s staff has indicated that you should be identified as an underwriter in the Registration Statement.
	 	 	 
	 	(c)	Are you an affiliate of a broker-dealer?
	 	 	 
	 	 	Yes o   No o
	 	 	 
	 	 	If you answered “yes”, provide a narrative explanation below:

                                                

                                                

	 	 	 
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	 	(d)	If you are an affiliate of a broker-dealer, do you certify that you bought the Registrable Securities in the ordinary course of business, and at the time of the purchase of the Registrable Securities to be resold, you had no agreements or understandings, directly or indirectly, with any person to distribute the Registrable Securities?
	 	 	 
	 	 	Yes o   No o
	 	 	 
	 	 	Note: If you answered “no”, the SEC’s staff has indicated that you should be identified as an underwriter in the Registration Statement.


 






    A-3



     


    

 


PART V. Beneficial Ownership of Other Securities of the Company
Owned by the Selling Stockholder:


 


Except as set forth below in this Part V, the undersigned
is not the beneficial or registered owner of any securities of the Company, other than the Registrable Securities listed above in Part III.


 


Type and amount of other securities beneficially
owned:


 





	 	 
	 	 
	 	 
	 	 
	 	 



 


PART VI. Relationships with the Company:


 


	 	(a)	Have you or any of your affiliates, officers, directors or principal equity holders (owners of 5% or more of the equity securities of the undersigned) held any position or office or have you had any other material relationship with the Company (or its predecessors or affiliates) within the past three years?
	 	 	 
	 	 	Yes o   No o
	 	 	 
	 	(b)	If your response to Part VI(a) above is “yes”, please state the nature and duration of your relationship with the Company:





 





	 	 
	 	 
	 	 
	 	 
	 	 








 


PART VII. Plan of Distribution:


 


The undersigned has reviewed the form of Plan of
Distribution attached as Annex I hereto, and hereby confirms that, except as set forth below, the information contained therein regarding
the undersigned and its plan of distribution is correct and complete.


 


State any exceptions here:


 








	 	 
	 	 
	 	 
	 	 
	 	 


 









    A-4



     


    

 


The undersigned agrees to promptly notify the Company
of any inaccuracies or changes in the information provided herein that may occur subsequent to the date hereof and prior to the effective
date of any applicable Registration Statement. All notices hereunder shall be delivered as set forth in the Registration Rights Agreement.
In the absence of any such notification, the Company shall be entitled to continue to rely on the accuracy of the information in this
Notice and Questionnaire.


 


By signing below, the undersigned consents to the
disclosure of the information contained herein in its answers to Parts I through VII above and the inclusion of such information in the
Registration Statement and the Prospectus. The undersigned understands that such information will be relied upon by the Company in connection
with the preparation or amendment of any such Registration Statement and Prospectus.


 


By signing below, the undersigned acknowledges
that it understands its obligation to comply, and agrees that it will comply, with the provisions of the Exchange Act and the rules and
regulations thereunder, particularly Regulation M in connection with any offering of Registrable Securities pursuant to the Registration
Statement. The undersigned also acknowledges that it understands that the answers to this Notice and Questionnaire are furnished for use
in connection with registration statements filed pursuant to the Registration Rights Agreement and any amendments or supplements thereto
filed with the SEC pursuant to the Securities Act.


 


The undersigned confirms that, to the best of his/her
knowledge and belief, the foregoing answers to this Notice and Questionnaire are correct.


 


IN WITNESS WHEREOF, the undersigned, by authority
duly given, has caused this Notice and Questionnaire to be executed and delivered either in person or by its duly authorized agent.


 


Dated: _____________


 


	 	Selling Stockholder
	 	 
	 	 
	 	Name of Entity or Individual
	 	 	 
	 	By:	 
	 	Name:	 
	 	Title:	 


 






    A-5



     


    

 


Annex I


 


Plan of Distribution


 






    A-6