j ..~ ~ ~ • ~ 

I 

r 

SANiTiZED 

REPC3RT 

DETERMINATIQN OIF Tk1E UENS9TY (LIQUfD) OF 

1,1,3,3-TETRAMETHYL®l1TYLPEROXY PMALATE 

., _ c~ c,~~ (`~ ~o~C 

~ 

IV01"OX Projed 

IdOi'OX Substanc~ 

a._--.-~ 

- Page 1 of 11 - 

N 
I 

1,1,3,3aTETRAN)ETHYLBUTYLPEROXY P{VAf_ATE NOTQK Proj+✓ct 

~ CUi•lFIi3ENTiALITY STATEMENT 

This report cQntains the unpublished re$uits of research sponsored by Akzo iVobef Ghemicafs 

B.V.. Reproductiorr, issue or disclosure io third parties in any form is not permitted without prior 

tnrritten authorization from the sponsor. 

~,, ... ',•.' . 

~ 11 ri x~ ~ 

-2 - 
1,1,3,3-TETRAMETHYL.BUTYL.PEROXY PIVALATE NOTOX Proje:ct 

STATEMENT OF GLPCOMPLIAN CE 

NOTQX B.V., 's-Hertogenbosch, The Netherlands 

The study described in this report has been correctly reported and was Gonducted in compliance 

with the most recent edition of: 

The OECD Principles of Good f„aboratory Praetice 

which are essentfally fn conformity with: 

The United States Food and Drug Administration. Title 21 Code of Federal Regulations Part 5$. 

The United States Environmental Protection Agency (F)FRA). Title 40 Code of Federal 

Regulations Part 130, 

The United States Environmental Protection Agency (TSCA). Titid 49 CQde of Federaf 

Regu(ations Part 792. 

Study Director 

1ng. H.J. Krips 

;. 

Date:\ 

( / 

nllanagement , 

Dr. !r. H. Vllillems 

Head of Chernistry 

~ 

Date: 

-3- 
-•• 

_ __~ 

1,1,3,3-TETRAMETHYLBUTYLPEROXY PIVALATE NOTOX Project ~ 

QUAL9TY ASSURA.NCE STATENIENT 

`- NOTOX B.V., `s-Hertogenbosoh, The Netherlands 

This reporl was audited dy the (VOTOX Quaiity Assurance lJnat to ensure that the rneth4ds and 

results accurafioly reflect t'ne raw data. 

The dates of Quality Assurance inspections anci audits are given below. 

uuring [ne orl-slie inspeCiioris prouedures applicdhie io thls typG o ~ sfiudy vvere in: pectert. 

DATES OF QAU lNSPECTtOtVS/AUl=91TS 

on-site inspection (s) 

04 January 2000 

12 January 2000 

protocol inspecfion (s) 

07 March 2000 

report e,udit (s) 

14 Nlarch 2000 

Head Qf Cuality Assurance 

C.J. Mitpbell Q_Sc. 

, 

.,.:: ~5 

Date; 

REPORTING DATES 

04 January 2000 

12 January 2000 

07 March 2000 

14 lvlarch 2000 

e q, _ 
~ 

1,1,3,3-TETRAMETHYLBUTYLPEROXY PIVALATE NOTOX Project~ ~ 

~ SUMMAHY ~ 

The determination of the derasity (Eiquid) was based on the EEC-Directive 92169 EEC, A.3 

"Relative density" (1992) and on the OECD Guidetine no. 109 "Dertsity of llquids and solids" 

(1995). 

~ Theslensit-v- of theliquid-test substartce 1,1,3,3-TETRAMETHYLBUTYLPEROXY PIVALATE is 

~f . _ A giass-pycrt©metex~with nominal volume of 10 ml was used. I 

T$mperature of ineasurement was 20.0 ± 0.5°C. i 

 - 

The D~° is 0.89. 

~ 

~ 

I 

1 

I 

-5- 
1,1,3,3-TETRAMEi"HYLBUTYLPEFdOXY PIVALATE NOTOX Project; 

PREEACE 

I Sponsor AKZO Nobel Chemicals B.V. 

P.O. Box 247 

3800 AE Amersfoort I ~,.. Th ~ 1Vetherlands --- -.k. 

~` ",~--_..._ 

Study lvtonitor 

Testing Pacility NOTOh B.V. ~ 

Hambakenwetering 3 

I 5231 DD 's--Hertogenbosch 

The Netherlands 

~ Study Director 

Study Plan Stark : 08 March 2000 

i 

I 

Completed : 08 March 2000 

~ TEST SUBSTANCE 

! (dentification 1,1,3,3mTetramethylbutylperoxy Pivafate 

~ AFCZO Nobel trade narne Trigonox 425 

Chemical name 1,1,3,3°Tetrarnethylbutylperoxy Pivalate 

CAS No. 22288-4 1-1 

~ Description __M-Cotourless liauid 

Batch 

I Purity (See Ce'tiritifida3e af Analysis) 

Test substance stQrage 1n freezer in the dark 

i Stability under storage 

i eonditirarrs Stable 

I Expiry date 01 June 2004 

I The sponsor is respansible for the cornpleteness and CLP Compliance of ail test substance 

riata. 

~ 

j PURPOSE -- - 

I The purpose ofi the study was to determine the density of the test substance at a specific 

temperature by means of a pycndrneter. 

I 

I 

CUIDELIhIES 

I ~ 

The study procedure describecf in this reporf is based on the foltowing guidelines: 

I I Organization for Economic Co-operation and Developrnent (OECD), OECD guidelines for 

Testing of Chemicals, guideline No. 109: "Density of lictuids and salids", LJuly 27, 1995. 

~ European Econornic Community (EEC), EEC-airective 92/69 EEC, Part A, Methods for the 

~ determination af physico-chemica! properties, A.3 °Relative density", EEC Publication IVo. L383, 

I December 1992. 

a M. 
1,1,3,3-TETRAMETHYLBUTYLPERQXY PIVAI..ATE NOTGX Project: ~ 

• ~~...4........~.~.-:~ 

~ . 

I ARCHIVING 

~ NOT4X B.V. will archive the following data for at least 10 years; protocol, report, test substance ~ ~ reference sampie and raw data. Thereafter, no data will be withdrawn without the sponsor's 

I written consent. ! i 

. ~ 

, I 

I TEST SYSTEM AND RATIONALE ~ ~ Test system A pycnometer with a ground-in thermometer and a 1 

l caplilary side-tuke and with a volume of 14 ml. I 

Wei hin s An anai icaf balance with an ac+curac of 0.7 m_ I I 9 g Yt Y' 9 ~ 

Conditions AII manipulations were performed at 20.0 ± 0.5°C with I 

gquipment having the same temperature. ~ 

Rationafe Recognazed by the internat#onal guidelines as I 

recornmended test system (EEC, OECD). I 

~ PERFtJRMANCE CJF THE TEST j 

~ First the volume of the pycnometer was determined ( in duplicate); the pycnometer was weighed I 

 dry and empty (A), fil7ed with Niilli-Q water (Nliliipore Corp., Sedford, MA, USA), thoroughly dried 

~ on the outside and weighed again (B). I 

I The density ofi the liquid test substance was catculated from the difference in weight between I 

the full (C) and empty pycnometer (mean A) and its known votume {mean % This procedure 

was repeated until reproducible results (deviation in the density s 0.01 g/cm ) were obtained. ~ 

• • ~ ~ DATA HAN DLING j 

Definitions: ( 

The density of a substance is the quotient of the mass m and the volume v of that substance at I 

a specific temperature. i 

density = m/v j 

SI unit in kg/m3. One gram per cm3corresponds with 1000 kg/rn 3. I 

The i74 °: The ratio between the mass of a volume nf the test substance, ~ determined at 20 0C, and the mass of the same volume of water, determined i 

at 400. The relative density has na dimension. 

. ~ ~ 

. I 

I 

~ 

-7- 
1,1,3,3-TETRAMETHYLBUTYLPEROXY P1VALATE NOTOX Project: 

~ 

Calculations: 

The follawing calculations were performed: 

(B-A)JSNIIIV=Q 

(C ° Amfsen)JDmean 

=.; E density af the test substartce at the test temperature (glcrn 3) 

, A :z= weight of the empty pycnomefier (g) 

B = weight ofi ihe pycnometer with Milli-Q water (g) 

c = weight of the pycnometer with the test substance (g) 

Q = vo{urne of the pycnometer (crri) 

SMW = density of water at the test temperature (gJcm) (CRG Handbooft of Chemistry and 

Physics, 1981) 

RE'SUL`f"S 

The test was performed in duplicate. lndividLial results are shown in Tabfe 1. Measurernents and 

caiculations are shown in tPio Appendix. 

Table 1 Ueterm inations of the density of 1,1,3,3-TETR AMETHYLBUTYLPEROXY PIVAL,ATL 

Measurement Temperature of t?ensity 

measurerrient °C 4m 

1 20.0 ~ 

2 20.0 ( 

rn ean: r 

-.~.._ 

/ ......../. ._._l-+~ ._...-... ~ t.0. 

,,ir•r-,concfusion, fhe density of 1,1,3,3-TETRAfvtETHYLBUTYLPEROXY P1VALATE ~.is - ~ 

Tl-io D~° 

;. 
1,1,3,3-TETRAMETHYLBU7'YLf'ERt7XY PIVALATE NOTOX Pro}ect } i 

APPENDfX ~ 

. i 

Individual measurements 

E'xperiment 1 i Experiment 2 

PYCNOMEi"EFt EMPTY (A) 27.0989 g 27.0992 g 

TEMP.MILLI-Q WATER 20.0°C 20.0°C 

PYCNOMETER + MIl,L!-Q WATER (B) 36,8266 g 36.8313 g 

TEMP.TEST SUBSTANCE 20.0°C 20.0°C 

PYCNOMETEFt + TEST SUBSTANCE (C) 35.7459 g 35.7454 g 

Calculations 

1. SMW (resufting frgm the test temperatura) = 0.9982 g/c0 

2. Volume pycnometer = D = (B - A) / SMW 

Exp. 1: D= 9.7452 cm3 

Exp. 2: D= 9.7496 cros 

Mean D= 9.7474 cma 

3.Density test substance =(C - A )/ D 

msan mean 

Exp. 1 : density ~ 

Exp. 2 : density 

Mean density = 0.89 g7cm~'~ 

WE 
, 1,1,3,3-TETRAMETHYLBUTYLPERQXY P1VAZATE 

I 

APPENDIX: CERTIFtCATE OF ANALYSiS 

r~,.,..----.."„ti`A 

NQTQX Proj~ ect 

-~._.......w...- 

_~----~~% 

x Yr- ~r~ ~ i,n~~~ 

SCs-33i 

'oduct name : 1,1,3,3-tetramethylbutyl peroxypivalate 

ade narne : Tn~ o~t~_o_x425 

3tch tiumb'er ~ 

Test results: - -- --~---~-~~ 

~ 

~ 

File cade 

Analytrcal documentatian 

Authorized hu----- ~------___ 

Name ~ Functian 

Date 

Signature 

~~~ 
1,1,3,3-TETRAMETNYLBEITYLPERQXY PlVALATE IVOTOX Project 

.,~...._.__..r..~ 

Central Research 

~ • 

I 

page 2 of 2 

Trigonox 425 batck 

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-11 -