EX-10.10





 Exhibit 10.10 

AMENDMENT NO. 2 
 TO THE LICENSE
AGREEMENT 
 BETWEEN INTRINSIC MEDICINE, INC. (FKA LUPA BIO, INC.) AND 

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 
 This
Amendment No. 2 to the License Agreement (this “Amendment No. 2”) is entered into by and between Intrinsic Medicine, Inc. (fka Lupa Bio, Inc.) (hereinafter “LICENSEE”) and the Regents of the University of California
(“UNIVERSITY”) represented by its San Diego campus (“UC San Diego”), each referred to herein as a “Party”, or collectively as the “Parties”. Capitalized terms used herein and not otherwise defined have the
meanings ascribed to them in the License Agreement. 
 WHEREAS, and the University entered into a License Agreement, UC San Diego Control Number 2019-03-0146 (the “Agreement”) effective October 10, 2018 (“Effective Date”) whereby LICENSEE obtained certain rights from University for Therapeutic
Products. 
 WHEREAS, the Parties amended the Agreement with Amendment No. 1, UC San Diego Control Number 2019-03-0146 (R501), effective October 10, 2019 to modify certain terms in the Agreement. 
 WHEREAS,
the Parties now wish to amend the Agreement, to be effective upon the date of last signature of this Amendment No. 2 (“Amendment No. 2 Effective Date”), to modify certain terms in the Agreement. 

NOW, THEREFORE, the Parties hereto agree as follows: 

Amendment Fee 
 Within thirty (30) days of the
Amendment No. 2 Effective Date, LICENSEE will pay to UNIVERSITY an amendment fee of three thousand dollars ($3,000). 
 With respect to the
Preamble 
 The address of LICENSEE shall be changed to: [***]. 

Article 4.1. Reports (b), last paragraph shall be deleted and replaced with: 

If no sales of Licensed Products have been made and no Sublicense revenue has been received by LICENSEE during any reporting period, LICENSEE shall so report.
The reports referred to in this Paragraph 4.1(b) should be marked with the following title and case number: “License Agreement between UC SAN DIEGO and Intrinsic Medicine, Inc. for case number
SD2018-048.” Reports shall be submitted as an attachment to UC SAN DIEGO’s email address: oic-reports@ucsd.edu. 

  
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 Article 10. MISCELLANEOUS PROVISIONS (c) 

Licensee’s address shall be changes as follows: 
 If sent to
LICENSEE: 
 Intrinsic Medicine, Inc. 

[***] 
 [***] 

Attention: [***] 
 Phone: [***]

 Email: [***] 
 Exhibit C –
Milestone Payments shall be deleted and replaced with: 
  

			
	 Milestone
	  	 Payment

	[***]	  	[***]
	[***]	  	[***]
	[***]	  	[***]
	[***]	  	[***]
	[***]	  	[***]
	[***]	  	[***]

 Exhibit D-Due Diligence shall be deleted and replaced with: 

 

					
	 Milestone
	  	 Due Date
	  	 Status

	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]


  
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 Capitalized terms shall have the meaning assigned to them in the License Agreement. Except as expressly and
unambiguously stated herein, no other changes are made to the License Agreement. All other terms and conditions of the License Agreement shall remain in full force and effect. The License Agreement, Amendment No.1 and this Amendment No. 2 shall
constitute the entire understanding of the parties with respect to the subject matter hereof and supersede any prior understanding, oral or written, between the parties with respect thereto. The License Agreement, Amendment No.1 and this Amendment
No. 2 shall be governed in all respects by the laws of the State of California without regard to its conflict of laws provisions. 
 The parties agree
that this Amendment No. 2 may be executed electronically and in two (2) or more counterparts each of which shall be deemed an original and all of which together shall constitute but one and the same instrument. 

[SIGNATURE PAGE FOLLOWS] 

  
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 IN WITNESS WHEREOF, each of the parties has caused this Amendment No. 2 to the License to be executed
by a duly authorized representative. 
  

									
	INTRINSIC MEDICINE, INC.:	  	        	  	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA:
					
	By:	  	 /s/ Alexander Martinez
	  		  	By:	  	 Victoria Cajipe

	Name: Alexander Martinez	  		  	Victoria Cajipe, Ph.D.
	Title: CEO & Co-Founder	  		  	Associate Director
	Date:	  	11/30/2020	  		  	Date:	  	11/30/2020


  
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 [***]