Exhibit 10.11


 


CERTAIN CONFIDENTIAL
INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE
HARM TO THE COMPANY IF PUBLICLY DISCLOSED


 


THIRD AMENDMENT


TO


EXCLUSIVE LICENSE AGREEMENT


 


This THIRD AMENDMENT
TO EXCLUSIVE LICENSE AGREEMENT (this "Amendment") is made and entered into as of October 24, 2019 (“Third Amendment Effective
Date”) by and between Belite Bio, Inc ("Company") and The Trustees of Columbia
University in the City of New York ("Columbia").


 


W I T N E S S
E T H:


 





 



 




WHEREAS, Columbia and LIN BIOSCIENCE, INC. are
parties to that certain Exclusive License Agreement dated September 13, 2016, and amended on August 15, 2017 (the “License Agreement”);


 


WHEREAS, LIN BIOSCIENCE, INC. and LIN BIOSCIENCE
INTERNATIONAL LTD. entered an agreement dated June 30, 2018 to assign the License Agreement to LIN BIOSCIENCE INTERNATIONAL LTD. (the
 “First Assignment”);


 


WHEREAS, LIN BIOSCIENCE INTERNATIONAL LTD. and
Company (formerly known as Lin BioScience Co., Ltd.) entered an agreement dated July 1, 2018 to assign the License Agreement to Company
(the “Second Assignment”);


 


WHEREAS, Columbia provided its consent to the
First Assignment and the Second Assignment dated May 3, 2018;


 


WHEREAS, Company and
Columbia are parties to the License Agreement, and amended on March 28, 2019 (collectively, the “Agreement”). Each
capitalized term used herein, and not otherwise defined herein, shall have the meaning set forth in the Agreement;
and


 


WHEREAS, Company and
the Columbia wish to amend the Agreement in certain respects;


 


NOW, THEREFORE, in consideration of the premises
and the mutual covenants herein set forth, the parties hereto hereby agree as follows:


 






     


     


    

 


		1.	The first two lines of Section 2b of the Agreement is deleted in its entirety and replaced with the following:



 


“Columbia grants to Company the
right to grant sublicenses, provided that (i) the Sublicensee agrees to”


 


		2.	Section 4c(ii) of the Agreement shall be deleted in its entirety and replaced
with the following:



 


“Company or Sublicensee, as applicable,
will pay to Columbia an amount equal to [***] of Priority Review Voucher Revenue. If Company or Sublicensee, as applicable, have not sold
the Priority Review Voucher [***] receipt of the Priority Review Voucher, royalties due under Section 3b(ii)(A)(1) shall [***] of Net
Sales of Patent Products.”


 


		3.	Section 4d shall be amended by adding the following language at the end of
the provision:



 


“In the event that Company achieves
a milestone for a Product without the need to achieve any milestone(s) preceding it, Company will pay Columbia the milestone payment for
the achieved milestone and payment(s) due for any preceding milestone(s) not already paid for such Product.”


 


		4.	Except as expressly set forth in this Third Amendment, the Agreement shall
remain in full force and effect. If there is any inconsistency or conflict between this Third Amendment and the Agreement, the provisions
of this Amendment shall govern and control. This Third Amendment may be executed in any number of counterparts, each of which shall be
deemed an original, but all of which together shall constitute one and the same instrument. This Third Amendment shall be binding upon,
and shall inure to the benefit of, the parties hereto and their respective successors and assigns. 



 


IN WITNESS WHEREOF, the parties hereto have caused
this Third Amendment to the License Agreement to be executed as of the date first above written.


 


	 	THE TRUSTEES OF COLUMBIA

 UNIVERSITY IN THE CITY OF NEW YORK
	 	 	 
	 	 	 
	 	By	/s/ Scot G. Hamilton






	 	Name:	Scot G. Hamilton
	 	Title:	AVP





	 	
    TTs#55016
    

	 	 
	 	
    BELITE BIO, INC 

    

	 	 
	 	 
	 	By	/s/ Tom Lin






	 	
    Name:

    
	Tom Lin
	 	
    Title:

    
	Director