Filed by Bowne Pure Compliance




Exhibit 10.29


	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT	 	1. CONTRACT ID CODE	 	 	 	PAGE OF PAGES
	 

	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	1	 	 	1	 	 
	 
	2. AMENDMENT/MODIFICATION NO:	 	 	 	3. EFFECTIVE DATE	 	4. REQUISITION/PURC	 	5. PROJECT NO. (If applicable)
	Four (4)	 	 	 	April 4, 2008	 	N/A	 	 	 	N/A	 	 	 	 	 	 
	 
	6. ISSUED BY	 	CODE	 	 	7. ADMINISTERED
BY (If other than Item 6)	 	CODE	 
	 
	Assistant Secretary for Preparedness and Response (ASPR)

Biomedical Advanced Research and Development Authority (BARDA)

U.S. Department of Health and Human Services

330 Independence Avenue, SW Room G640

Washington, DC 20201	 	 	 	 	 	 	 	 	 	 
	 
	8. NAME AND ADDRESS OF
CONTRACTOR (No., street, county, State and ZIP Code)	 	þ 	 	9A. AMENDMENT OF SOLICITATION NO.	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	BioCryst Pharmaceuticals, Inc

2190 Parkway Lake Drive

Birmingham, AL 35244

DUNS 61-819-4609

	 	 	 	 	 	 	 	9B. DATED (SEE ITEM 11)	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 	 	 	 	þ 	 	10A. MODIFICATION OF CONTRACT/ ORDER 
    HHSO100200700032C
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	10B. DATED (SEE ITEM 13)	 	 	 	 
	CODE	 	 	 	 	 	FACILITY CODE	 	 	 	 	 	01-03-07	 	 	 	 
	 
	11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS
 
	o The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers o is extended, o is not extended.
	 
	Offers must
acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods: (a) By completing Items 8 and 15, and returning
              
copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR
ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE
RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN
REJECTION OF YOUR OFFER. If by virtue of this amendment, you
desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.
	 
	12. ACCOUNTING AND
APPROPRIATION DATA (If required)
	SOCC:                      DOC#                      TIN#                      LOC#              
        CAN#                     
	 
	13. THIS ITEM APPLIES ONLY TO MODIFICATIONS OF CONTRACTS/ORDERS; IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.
	 
	 	 	A.	 	THIS CHANGE ORDER IS
ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	B.	 	THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT
 THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR

43.103(b).	 	

	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	þ 	 	C.	 	THIS SUPPLEMENTAL
AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:


Far 1.602-1,
FAR 52-242-15 Stop-Work Order	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	D.	 	OTHER (Specify type of modification and authority)	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	E. IMPORTANT: Contractor o is not, þ  is required to sign this document and return 2 copies to the issuing office.
	 
	14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible)
	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	PURPOSE: The purpose of this modification is to:
	 
	 	 	1. Extend the period
of the Stop-Work Order issued January 4, 2008 an additional 90 days
from April 4, 2008  through July 3, 2008. 
	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	The total contract amount remains unchanged. ($102,661,429)
	 
	The contract completion date remains unchanged. (December 31, 2010)
	 
	Except as provided herein, all terms and conditions referenced in item 9A or 10A, as heretofore changed, remains full force and effect.
	 
	15A. NAME AND TITLE OF SIGNER (Type or print)	 	16A. NAME AND TITLE OF CONTRACTING OFFICER (Type or print)
	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 Michael Darwin	 	 	 	 	 	Schuyler T. Eldridge	 	 	 	 	 	 	 	 
	 
	15B. CONTRACTOR/OFFEROR	 	 	 	15C. DATE SIGNED	 	16B. UNITED STATES OF AMERICA	 	 	16C. DATE SIGNED
	 
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 

	/s/ Michael Darwin	 	4/3/08 	 	BY  /s/ Schuyler T. Eldridge                        	 	 	 	4/3/08
	(Signature of person authorized to sign)	 	 	 	(Signature of Contracting Officer)	 	 	 	 	 	 	 	 	 	 
	 
	NSN
7540-01-152-8070	 	 	 	OMB No. 0990–0115	 	STANDARD FORM 30 (REV. 10-83)