UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

March 3, 2015 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

Office of Pesticide Programs 

Registration Division (7505P) 

MEMORANDUM DER for acute toxicity studies for 1 00-RUAL 

Subject: Name ofthe Product SYN-Al6003 Herbicide 

EPA File Symbol: 100-RUAL 

DP Barcode 411849 

Decision No 4 70873 

Action Code: ROlO.O 

PC Code: 018986 

From: 

C

Princess 

ITAB 

Campbell, DVM, MS, DACVPM P -\ ~ \ 

Through: John Redden, M.S.l ( V\--

CITAB 

Registration Division (7505P) 

To: Grant Rowland/Kathryn Montague RM 23 

Herbicide Branch 

Registration Division (7505P) 

Applicant: Syngenta Crop Protection, LLC. 

Greensboro, NC 27419 

FORMULATION FROM LABEL: 

Active Ingredient(s): 

Bicyclopyrone 

Other Ingredient(s): 

Total: 

%by wt. 

18.5 

_ll2 

100.0 
Bicyclopyrone (A~6003) 

Reviewer: Princess Campbell, DVM 

BACKGROUND: 

Syngenta Crop Protection, LLC has submitted a set of six acute toxicity studies to support the 

registration of SYN- A 16003, an herbicide. The toxicity studies were performed by Harlan 

Laboratories Ltd, Wolferstrasse 4, Switzerland, in 2009 (MRIDs 47842224- 29). 

Deficiencies: All studies are in compliance with EPA guidelines; any deficiency is not 

significant and does not affect the outcome of the study. 

FINDINGS: 

All six studies have been classified as acceptable. 

The toxicology profile is as follows: 

Acute oral toxicity IV acceptable 

Acute dermal toxicity IV acceptable 

Acute inhalation IV acceptable 

Primary eye irritation IV acceptable 

Primary dermal irritation IV acceptable 

Dermal sensitization -ve acceptable 

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MRID 47842224 

MRID 47842225 

MRID 47842226 

MRID 47842227 

MRID 47842228 

MRID 47842229 
Bicyclopyrone (Al6003) 

Reviewer: Princess Campbell, DVM 

LABEL: 

PRODUCT ID #: 000100-01465 

PRODUCT NAME: SYN-A16003 

PRECAUTIONARY STATEMENTS 

SIGNAL WORD: CAUTION 

Hazards to Humans and Domestic Animals: 

Wear: Long-sleeved shirt and long pants, Socks, Shoes, and chemical-resistant gloves (such as Natural 

Rubber, Selection Category A). 

User Safety Recommendations: 

Users should remove dothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on 

clean clothing. 

Users should remove PPE immediately after handling this product. Wash the outside of gloves before 

removing. As soon as possible, wash thoroughly and change into clean clothing. 

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Bicyclopyrone (A16003) 

Reviewer: Princess Campbell, DVM 

**DER ti or Fl" 1e S ;ym b o I 100 -RUAL 

1. DP BARCODE: 411849 

l. PC CODE: 018986 

3. CURRENT DATE: February 3, 2015 

4. TEST ARTICLE: NOA449280 SL; Batch #: 18308/ 145; Brown liquid; 

Study/Species/Lab MRID Results Tox Core 

Study # /Date Cat Grade 

Acute oral toxicity I rat 47842224 LDso females is > 5000 mglkg mgt kg IV A 

Harlan Laboratories Ltd /C26644/08-

25-2009 

OCSPP 870.11 00; OECD 425; 

JMAFF 12 Nohsan 8147 

Acute dermal toxicity /rat 47842225 Dermal LDso Males/females > 5000 IV A 

I Harlan Laboratories Ltd mglkg bw 

/C26655/08-24-2009 

OCSPP 870.1200; OECD 402; 

JMAFF 12 NohSan 8147 

Acute inhalation toxicity I rat 47842226 LCso Males and females > 5.08 mg!L IV A 

LAB Research Ltd /09/052-004P/04- MMAD= 3.10 1-1m 

08-2009 GSD .. 3.22 

OCSPP 870.1300; OECD 403; All survived exposure (nose only). 

JMAFF 59 Nohsan 4200 

Primary Skin irritation I rabbit 47842227 Non irritating IV A 

Harlan Laboratories Ltd /C26666/09-

17-2009 

OCSPP 870.2400; OECD 404; 

JMAFF 12 NohSan 8147 

Primary eye irritation I rabbit 47842228 Slightly irritating IV A 

Harlan Laboratories Ltd /38396/08-

12-20009 

OCSPP 870.2500; OECD 405; 

JMAFF 12 NohSan 8147 

Dermal sensitization I mouse LLNA- 47842229 Negative. -- A 

Harlan Laboratories Ltd /C26688/09- Positjve control (5% HCA): 

29-2009 

OCSPP 870.2600; Nohsan 8147 

Core Grade Key: A =Acceptable, S = Supplementary, U = Unacceptable, D = Data Gap 

** Detailed DER completed for acute toxicity studies (6 pack) in Global Joint Review format. 

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