### UNITED STATES ENVIRONME NTAL PROTECTION AGENCY WASHINGTON , D .C. 204 60

March 3, 20 15 OFFICE OF C HE MICA L SAFETY AND POLLUTI ON PREVENTION 

### Office of Pesticide Program s Reg istrati on Divis ion (7505P)

MEMORANDUM DER for acute tox icity s tudi es for 1 00-RUAL Subject: Name ofthe Product SYN

- Al6003 Herbicide EPA File Symbo l : 100-R UA L DP Barcode 411849 Decis i on No 470873 Actio n Code: ROlO.O PC Code : 018986 From: 

## Princess Campbell , DVM , MS , DACVPM 

# P

- \

**~** C ITAB \ Through : John Redden , M.S.l ( 

# V\-- CITAB Registration Division (7505P) T o: Grant Rowland / Kathryn Montague 

## RM 23 Herb icide Branch Registration Division (7505P) App li can t: Syngenta Crop Protect ion, LLC
. Greens boro, NC 274 19
FO RMULATION FROM LABEL: Active Ingr edient(s) : Bicyclopyrone Other Ingredient( s): Total : %by wt. 

### 18 .5 _ll2 

### 1 00 .0

### Bicyclopyrone

**(A~6003)** 

### Reviewer: Princess Campbell, DVM 

### BACKGROUND: Syngenta Crop Protection, LLC has submitted a set of six acute tox icity studies to sup port the regist ration of SYN- A 16003, an herbicide. The toxicity studies were performed by Harlan Laboratorie s Ltd, Wolferstrasse 4 , Switzerland, in 2009 (MRIDs 47842224- 29). Deficiencies: All studies are in com plianc e with EPA guidelines ; an y deficiency i s not significant and doe s not affect the outcome ofthe stu d y. FINDINGS: All s ix studies have been classified as acc eptable. The toxicology profil e is as follows: Acute oral toxicity IV acceptable Acute dermal toxicity IV acceptable Acute inhalation I V acceptable Primary eye irritation IV acceptable Primary dermal irritation 

### IV acceptable Dermal sensitization -ve acceptable

2 

### MRID 47842224 MRID 47842225 MRID 47842226 MRID 47842227 MRID 47842228 MRID 47842 229Bicyclopyrone (Al6003) Reviewer: Princess Campbell, DVM



### LABEL: PRODUCT 

### ID #: 000100-01465 PRODUCT NAME: SYN-A16003 PRECAUTIONARY STATEMENTS SIGNAL WORD: CAUTION Hazards to Humans and Domestic Animals: Wear: Long-sleeved shirt and long pants, Socks, Shoes, and chemical-resistant gloves (such as Natural Rubber, Selection Category A).


### User Safety Recommendations: Users should remove doth ing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing. Users should remove PPE immediate ly after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing.

3Bicyclopyrone (A 16003) Reviewer: Princess Campbell, DVM **DER ti Fl" S b I 100 RUAL or 1e ;ym o 

# - 1. DP BARCODE: 411849 

### l. PC CODE: 018986 3. CURRENT DATE: F ebruary 3, 2015 4. TEST ARTICLE: NOA449280 SL ; Ba tch # : 18308 / 145 ; Brown liqu id ; Study/Species/Lab MRID Results Tox Core Study # /Date Cat Grade Acute oral toxicity 

### I rat 47842224 LDso females is 

### > 5000 mglkg mgt kg 

### IV A Harlan Laboratories Ltd / C26644 / 08- 25-2009 OCSPP 870.11 00; OECD 425; JMAFF 12 Nohsan 8147

Acute dermal toxicity / rat 47842225 Dermal LDs o Males / females 

### > 5000 

### IV A 

### I Harlan Laboratories Ltd mglkg bw / C26655/ 08-24-2009 OCSPP 870.1200; OECD 402; JMAFF 12 NohSan 8147 Acute inhalation toxicity 

### I rat 47842226 LC s o Males and females 

### > 5.08 mg!L 

### IV A LAB Research Ltd / 09/052-004 P / 04- MMAD= 3.10 1-1m 08

-2009 GSD
.. 3.22 OCS PP 870.1300; OE CD 403; All survived exposure (nose on ly). JMAFF 59 Nohsan 4200 Primary Skin irritation 

### I rabbit 47842227 Non i rritating 

### I V A Harlan L aboratories Ltd /C26 666/ 09- 17-2009 OCSPP 870.2400; OECD 404; JMAFF 12 NohSan 8147 Primary eye irritation 

### I rabbit 47842228 Slightly irritating 

### IV A Harlan Laboratories Ltd / 38396 /08- 12-20009 OCSPP 870. 250 0; OECD 405; JMAFF 12 NohSan 8147 Dermal sensitization 

### I mouse LLNA- 47842229 Negative.


# -- A Harlan Laboratories Ltd / C26688/ 09- P ositjve control (5% HCA): 29-2009 OCSPP 870.2600; Nohsan 8147 Core Grade Key: A =Acceptable , S = Supplementary , U = Unacceptable , D = Data Gap 

## ** Detailed DER completed for acute toxic i ty studies (6 pack ) in Global Joi nt Review format.

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