### COOING FORM FORSRC INDEXING

Micrcfir:ho No.

. OTS0522945 

### REVISED 10115/86

REPORT ON THE STUDY OF THE ACUTE ORAL TOXICITY OF HEXABROMOCYCLODODECANE IN THE MOUSE WITH COVER LETTER DATED 031290

HEXABROMOCYCLODODECANE (3194-55-5)



# ..Attention: 8(d) Health & safety Reporting Rule Notification ·U. S. Environmental Protection Agency

Document Processing Center (TS-790) Office of Toxic Substances 401 M Street, sw Washington, DC 20460 BASFCorporation
Certified Mail Return Receipt Requested
March 12, 1990

Ladies and Gentlemen: 

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### &Safety Study Reporting 54 Federal Register 51114, December 12, 1989 25th ITC Report In response to the TSCA reporting rule referenced above, BASF Corporation is**subm~tting** the attached studies on: CAS Reg. No. 1163-19-5 3194-55-6 32534-81-9 32536-52-0 DECABROMODIPHENYLETHER Decabromodiphenyl Ether Hexabromocyclododecane Pentabromodiphenyl Ether Octabromodiphenyl Ether CAS REG. NO. 1163-19-5 1. Bericht uber Versuche zur Ermittlung der mittleren todlichen Dosen funf verschiedener verbindungen, 10.03.1976 2. Ames Metabolic Activation Test to Assess the Potential Mutagenic Effect of Bromkal 82-0 DE, 

### 08.n.1978 3. Ames Metabolic Activation Test to Assess the Potential Mutagenic Effect of Muster 83, 17.10.1984 4. Ames Metabolic Activation Test to Assess the Potential Mutagenic Effect of Muster 88, 16.10.1984 5. Final Report. 14-Day Repeated Dose Feeding Study

- Mice, 13.11.1978 6. Final Report. 14-Day Repeated Dose Feeding Study

- Rats, 14.11.1978 7. 90-Day Subchronic Feeding Study in Rats on**Dec~bromo(fphenyl** Oxide, 27.07.1979

1609 BiddleAvenue. Wyandotte, Michigan 48192 (313) 246-6100Page 2 U. S. Environmental Protection Agency

DECABROMODIPHENYLETHER CAS REG. NO. 1163-19-5 (Cont.)

B. 90-Day Subchronic Feeding Study in Rats on Decabromodiphenyl Oxide, 27.07.1979 9. Results of 30-Day Rat Dietary Feeding Studies on Octabromobiphenyl SA-1902 and Decabromodiphenyl Oxide SA-1892.1, 2B.01.1971 c 10. Ergebnisbericht uber Untersuchungen ZUl.' Bildung von Po1ybromdibenzofuranen und -dioxinen wahrend der Extrusion von Polybutandio1-terephthalat (PBTP)i Flammschutzmittel: Decabromodiphenylether 11. Untersuchung zur Bildung von Polybrom-dibenzofuranen und dioxinen bei der Extrusion von Po1y-Butanedio1-terephthalat (PBTP)i Flamrnschutzmittel: Decabrom-diphenyletheri Tei1 2; Produktionsanlage HEXABROMOCYCLODODECANE CAS REG. NO. 3194-55-6

1. prufungsbericht uber die toxikologischen Untersuchungen mit Hexabromocyclododecan der Firma Chemische Fctbrik Kalk GmbH, Koln-Kalk an Laboratoriumstieren, 04.10.1971 2. Bericht uber die Prufung der akuten Toxizitat an der Go1- dorfe (Leuciscus idus L., Goldvariante), 1B.03.1988 3. Ames Test for Hexabromid S, 24.04.1978 4. Hexabromocyclododecane: 28-day feeding trials with rats (with Germany summary - 17.11.1969) 5. Hexabromocyclododecant 90·,day feeding trials with rats (with Germany summary 04.02.1970) 6. Report on the study of the irritation of Hexabromocyclododecane to the dorsal skin of rabbits after 20-hour exposure, 04.10.1962 7. Report on the study of the primary irritation of Hexabromocyclododecane to the eye of rabbits, 04.10.1962 8. Report on the study of the acute oral toxicity of Hexabromocyclododecane in the mouse, 04.10.1962 9. Notiz: ALD 50; Ratte, oral, 28.11.1962 10. Ames metaholic activation test to assess the**potenti~l** mutagenic effect of compound No. 49, 19.09.1978 'Page 3 U. S. Environmental Protection Agency

HEXABROMOCYCLODODECANE CAS 

### REG. NO. 3194-55-6 (Cont.) 11. Migration von HECD aus geschaumtern"Polystyrol,**27.06.8~** 12. Migration von Flarnmschutzmitteln aus geschaurntem Polystyrol 08.08.85, 19.12.85, 28.08.86 13. APME: Expandable Polystyrene Information Dossier, p 18 with Data to Aquatic toxicity and Bioaccurnulation (log Pow a.o.), March 1988 14. Algal Growth Inhibition Test, 1990/01/31 15. Determination of the acute toxicity of Hexabrornid S to the waterflea Daphnia magna Straus, 1990/01/30 16. Oxygen Consumption Test (using Pseudomonas putida by the test method of Robra), 1989/04/19 17. Biologische Abbau Tests, 1980/05/06, 1981/10/16 PENTABROMODIPHENYLETHER CAS REG. NO. 32534-81-9

1. Prufung der akuten Toxizitat au der Goldorfe, 13.02.1984 2. Toxicologische Prufung von Fenta-brom-diphenylaether 3. Prufung von Bromkal 70-5 DE im Augenreiztest 

### am Kaninchen, January 1981 4. Prufung von Bromkal 70-5 DE im Hautreiztest'am Kaninchen, January 1981 5. Ames metabolic activation**t~st** to assess the potential mutagenic effect of Bromkal 70-5 DE, 08.02.1978 OCTABROMODIPHENYLETHER CAS REG•.;:NO. 32536-52-0

1. Bericht uber Ve.rsuche zur Ermittlung der Vertraglichkeit von Bromkal 82-0DE-Ruckstand, Brorokal 79-BDE:"lliedrigschmelzend und Brornkal 79-8DE-Ruckstand, 04.09.1984 2. Ames metabolic activation test to assess the potential mutagenic effect of Muster 84, 12.10.1984 3. Ames metabolic activation test to assess the potential mutagenic effect of Muster 82, 30.10.1984Page 4 

## u: S. Environmenta:i Protection Agency

OCTABROMODIPHENYLETHER CAS REG

..**NO~** 32536-52-0

4.
5.
6. Ames metabolic activation test to assess the potential mutagenic effect of Muster 13, 15.05.1978 Prufung von Bromkal 79-8 DE im Augenre.iztest 

### am Kaninchen, June 1980 Prufung von Bromkal 79-8 DE im Hautreiztest 

### am Kaninchen, June 1980

submitting Site: 7. Bericht uber Versuche zur Ermittlung der mittleren todlichen Dosen funf verschiedener Verbindungen, 10.03.1976 8. Bericht uber Versuche**z~r** Ermittlung der mittleren todlichen Dosis von Bromkal 79-8 DE, 21.05.1976 BASF Corporation 8 Campus Drive Parsippany, NJ 07054 Submitting Official: Roberta A. Hurley Sr. Product Regulations Specialist BASF Corporation 1609 Biddle Avenue Wyandotte, MI 48192-3799 Telephone: (313) 246-6214 Please contact me at 313-246-6214 if you have any questions. Very truly yours, BASF CORPORATION

# V(oJMJ.A~ Roberta A. Hurley Sr. Product Regulatio s Specialist
mk Ene.BASFAktiengesellschaft AbteilungToxlkologie DepartmentToxicology :().6700 Ludwigshafen

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### .APR 171985 */by-dd; 4211

Sheet 1 000688456·

### ~-90000D~~3 the acute oral toxicity of HexabroBocyc1o

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# ~~~~**il~~~III~I~~** XII/252; Mouse/oral Report on the study**o~** dodecane in the mouse

Testing facility: BASF Aktiengesellschaft Department of Toxicology D-6700 Ludwigshafen/Rhein

Aim of the study: Estimate of the potential acute hazard after single oral administration (determination of the ALDSO)

Test substance No.: XII!252

Name of test substance: Hexabromocyclododecane

A detailed product characterization ia included in the raw data.



## * The original report of Oct. 4, 1962 is printed in German. It was translated into English**a~d** reprinted in respect to the reporting and evaluation standard of 1985. based on the raw data of 1962.

DiesesDokumententhalt Betriebs- und Geschaftsgeheimnissa derBASF. Es ist Eigentum derBASFund dar! nur%u demvon. 8ASFvorgesehenen Zwackverwendetwerden. Jedeandere oder daruberhinausgehendeVerwendung,Verwertur.g. Weitergabe. Vervielfaltigung oderVeroffenllichung bedar!derEinwilligung derBASF.

. Thisdocumentcontains manufacturingandtradesecretsof BASF. Itisthej)rOpel'tyof BASFand maybeused only**f.or;~hat** purposeforwhich itwasintendedbyBASF. Everyotheror, additionaluse. exploitation. reproduction, publicationor

.. •SUbmission tootherparties requirethewritten permis.sion :**of.B~SF,'** .. .. ... . .... XII!252; Mouse/oral

ACUTE ORAL TOXICITY

Test 8ubstanc. No.:

Name of test substance:

Form of**administrati~n:**

Route of administration:

Observation period:

Examinations:

RESULT Toxikologie Sheet 2

XII/252

Hexabromocyclododecane

The product was administered to the animals once by gavage as a**~O%** aqueous tragacanth suspension.

Oral

7 days

a) Determination of the approximative

- median lethal dose (ALD 50) b) Signs of**toxicit~** c) Necropsy of the animals sacrificed by carbon dioxide at the end of the observation period.

ALD 50 (mouse, oral): 

### > 6,400 mg/kg body weightXII/252; Mouse/oral

ACUTE ORAL TOXICITY

SIGNS: Increasing apathy, trembling. Late mortalities!

Dr.med.vet. Schulze

NECROPSY FINDINGS: Peritonitis. Product is not fully resorbed.

Dr.med.vet. Schulze

Responsible for correct translation:**.~** Toxlkologie Sheet :5

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