SAT Report

PMN Number: P-08-0733

SAT Date: 9/30/2008

Print Date: 3/21/2011

Related cases: CBI: Yes

Health related cases: P08-0734

Ecotox related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 1-2 1

 Persistence Bioaccum Toxicity Comments

3 U2

Exposure Based Review:

Health: No

Ecotox: No

Routes of exposure: Health: Inhalation, dermal, and drinking water.

Ecotox: No releases to water

Fate: ;

Keywords:

 Keywords: LUNG IMMUNO UNCERT-ONCO-LUNG

Summary of Assessment:

 Fate:

Fate Summary: P-08-0733-34

FATE: 

Solid with MP = Dec 500-600 EC (E)

S < 0.001 mg/L at 25 EC (E)

VP < 1.0E-6 torr at 25 EC (E)

BP > 400 EC (E)

H < 1.00E-8 (E)

POTW removal (%) = U via U

Time for complete ultimate aerobic biodeg = U

Sorption to soils/sediments = U

PBT Potential: P3BU
*CEB FATE: Migration to ground water = U

 Health:

 Health Summary: Absorption is poor all routes based on analogs. The PMN 

materials are multi-walled carbon nanotubes. There is concern for lung overload if respirable 

particles are inhaled and uncertain concern for cancer if inhaled. There is also concern for 

immunotoxicity. Low moderate concern.

 Test Data: negative in Salmonella and E coli (both materials were 

tested)

negative for chromosome aberrations in CHL cells (both materials were tested)

acute oral study in rats - no deaths or signs of toxicity at 2000 mg/kg (both materials tested)

not a dermal irritant (P08-0733)

very slight skin irritant (P08-0734)

not a dermal sensitizer in guinea pigs (both materials were tested)

4-hr nose-only inhalation study in rats - 1 of 10 died at 1.87 mg/l, increased respiratory rate, 

labored respiration, noisy respiration, hunched posture, piloerection, fur staining by test material, 

wet fur (P08-0733)

4-hr nose-only inhalation study in rats - no deaths at 1.65 mg/l, increased respiratory rate, 

hunched posture, piloerection, fur staining by test material, wet fur, abnormally dark lungs with 

patches

intratracheal administration of 0.2 mg/animal once a week for 6 weeks in hamsters animals were 

then kept for 2 years after first administration of test material (group 1 - vehicle alone; group 2 - 

test substance alone; group 3 - test substance plus benzo[a]pyrene; group 4 - test substance plus 

chrysotile and benzo[a[]pyrene) no deaths, crouching position, sedation, decreased body weight, 

suppressed body weight gain; carcinogenicity of test material is weak (no tumors in group 2)

 Ecotox:

Test 

Organism

Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 *

daphnid 48-h LC50 *

green algal 96-h EC50 *

fish _ chronic value *

daphnid _ chronic value *

algal _ chronic value *

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic Value _

Ecotox Values Comments: Predictions are based on SARs for neutral organic chemicals; 

SAR chemical class = -multi-walled carbon nanotubes; MW>1,000,000; solid; log 

Kow >> 10 (P); S = negligible; pH7; effective concentrations based on 100% active 

ingredients and nominal concentrations; DW hardness < 150.0 mg/L as CaCO3; and DW TOC 

<2.0 mg/L;
Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

*

SARs

SAR Class

Ecotox Factors Comments: 

 SAT Chair: Becky Jones