----

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|   | ☐ | REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 |
|--------|---------|------------------------------------------------------------------------------------------------|
|   | ☒ | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
|--------|---------|--------------------------------------------------------------------------------------|
|   | ☐ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
|--------|---------|------------------------------------------------------------------------------------------|
|   | ☐ | SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 |
|--------|---------|---------------------------------------------------------------------------------------------|

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| Title of each class                                                                         |   | Name of each exchange on which registered |
|---------------------------------------------------------------------------------------------|--------|-------------------------------------------|
| American Depositary Shares, each representing 1ordinary share, par value NIS 0.10 per share |   | Nasdaq Capital Market                     |
|                                                                                        |   |                                      |
| Ordinary shares, par value NIS 0.10 per share                                               |   | Nasdaq Capital Market*                    |
|                                                                                        |   |                                      |

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| Large accelerated filer ☐ | Accelerated filer ☒ | Non-accelerated filer ☐ |
|---------------------------------|---------------------------|-------------------------------|
| U.S. GAAP ☐ | International Financial Reporting Standards as issued by the International Accounting Standards Board ☒ | Other ☐ |
|-------------------|---------------------------------------------------------------------------------------------------------------|---------------|

----

----

| Exhibit Number  |   | Exhibit Description                                                                                                                                                                                                                                                     |   |
|-----------------|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|
|            |   |                                                                                                                                                                                                                                                                    |   |
| 2.1(5)          |   | Articles of Association, as amended May 31, 2015                                                                                                                                                                                                                        |   |
|            |   |                                                                                                                                                                                                                                                                    |   |
| 2.2(2)          |   | Form of Deposit Agreement dated as of July 21, 2011 among the Registrant, The Bank of New York Mellon, as Depositary, and all Owners and Holders from time to time of American Depositary Shares issued thereunder                                                      |   |
|            |   |                                                                                                                                                                                                                                                                    |   |
| 2.3(2)          |   | Form of American Depositary Receipt; the Form is Exhibit A of the Form of Depositary Agreement                                                                                                                                                                          |   |
|            |   |                                                                                                                                                                                                                                                                    |   |
| 4.3(1)          |   | Employment Agreement with Kinneret Savitsky, Ph.D., dated October 13, 2004                                                                                                                                                                                              |   |
|            |   |                                                                                                                                                                                                                                                                    |   |
| 4.5(1)          |   | Employment Agreement with Philip Serlin, dated May 24, 2009                                                                                                                                                                                                             |   |
|            |   |                                                                                                                                                                                                                                                                    |   |
| 4.6†(1)   |   | License Agreement entered into as of January 10, 2005, between BioLine Innovations Jerusalem L.P. and B.G. Negev Technologies and Applications Ltd.                                                                                                                     |   |
|            |   |                                                                                                                                                                                                                                                                    |   |
| 4.7(1)          |   | Assignment Agreement entered into as of January 1, 2009 entered into between BioLine Innovations Jerusalem L.P. and the Registrant                                                                                                                                      |   |
|            |   |                                                                                                                                                                                                                                                                    |   |
| 4.16†(1)  |   | License Agreement entered into as of November 25, 2007 between BioLine Innovations Jerusalem L.P. and Innovative Pharmaceutical Concepts, Inc.                                                                                                                          |   |
|            |   |                                                                                                                                                                                                                                                                    |   |
| 4.17†(10) |   | Amended and Restated License and Commercialization Agreement among Ikaria Development Subsidiary One LLC, the Registrant and BioLine Innovations Jerusalem L.P. dated August 26, 2009, as amended and supplemented                                                      |   |
|            |   |                                                                                                                                                                                                                                                                    |   |
| 4.18(11)        |   | BioLineRx Ltd. Amended and Restated 2003 Share Incentive Plan                                                                                                                                                                                                           |   |
|            |   |                                                                                                                                                                                                                                                                    |
| 4.20(1)         |   | Amendment to Employment Agreement with Kinneret Savitsky, Ph.D., dated January 2, 2004.                                                                                                                                                                                 |
|            |   |                                                                                                                                                                                                                                                                    |
| 4.30(4)         |   | Employment Agreement with David Malek, dated August 8, 2011                                                                                                                                                                                                             |
|            |   |                                                                                                                                                                                                                                                                    |
| 4.31(3)         |   | Form of Warrant to purchase American Depositary Shares                                                                                                                                                                                                                  |
|            |   |                                                                                                                                                                                                                                                                    |
| 4.32(7)         |   | Form of Warrant to purchase American Depositary Shares                                                                                                                                                                                                                  |
|            |   |                                                                                                                                                                                                                                                                    |
| 4.33            |   | License Agreement entered into as of September 2, 2012 by and between the Registrant and Biokine Therapeutics Ltd.                                                                                                                                                      |
|            |   |                                                                                                                                                                                                                                                                    |
| 4.34(9)         |   | Consulting Agreement with Arnon Aharon, M.D., dated January 1, 2014                                                                                                                                                                                                     |
|            |   |                                                                                                                                                                                                                                                                    |
| 4.35†(9)  |   | License Agreement entered into as of February 15, 2011 between the Registrant and Valorisation-Recherche, Limited Partnership                                                                                                                                           |
|            |   |                                                                                                                                                                                                                                                                    |
| 4.36(8)         |   | Executive Compensation Plan                                                                                                                                                                                                                                             |
|            |   |                                                                                                                                                                                                                                                                    |
| 4.37(10)        |   | Lease Agreement entered into as of August 7, 2014 between S.M.L. Solomon Industrial Buildings Ltd. and Infrastructure Management and Development Established by C.P.M. Ltd. as Lessor and the Registrant as Lessee, as amended (English summary of the Hebrew original) |
|            |   |                                                                                                                                                                                                                                                                    |
| 4.38†(10) |   | Investment and Collaboration Agreement entered into as of December 16, 2014 between the Registrant and Novartis Pharma AG                                                                                                                                               |

----

| Exhibit Number |   | Exhibit Description |
|----------------|--------|---------------------|

|            |   |                                                                                                                                                                                                 |
|-----------------|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 4.39†(11) |   | License Agreement entered into as of December 22, 2014 between the Registrant and Wartner Europe BV                                                                                                  |
|            |   |                                                                                                                                                                                                 |
| 4.40†     |   | Clinical Trial Collaboration and Supply Agreement entered into as of January 11, 2016 between Merck Sharp & Dohme B.V. and the Registrant                                                        |
|            |   |                                                                                                                                                                                                 |
| 4.41(12)        |   | Employment Agreement with Merril Gersten, dated March 1, 2016                                                                                                                                        |
|            |   |                                                                                                                                                                                                 |
| 12.1            |   | Certification by Chief Executive Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002                                                                                                   |
|            |   |                                                                                                                                                                                                 |
| 12.2            |   | Certification by Chief Financial Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002                                                                                                   |
|            |   |                                                                                                                                                                                                 |
| 13.1(12)        |   | Certification by Chief Executive Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002                                                    |
|            |   |                                                                                                                                                                                                 |
| 13.2(12)        |   | Certification by Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002                                                    |
|            |   |                                                                                                                                                                                                 |
| 15.1(3)         |   | Form of Purchase Agreement between the Registrant and the Purchasers named therein, dated February 2012                                                                                              |
|            |   |                                                                                                                                                                                                 |
| 15.4(7)         |   | Subscription Agreement entered into as of February 6, 2013 between the Registrant and OrbiMed Israel Partners Limited Partnership                                                                    |
|            |   |                                                                                                                                                                                                 |
| 15.5(12)        |   | Consent of Kesselman & Kesselman, Certified Public Accountant (Isr.), a member of PricewaterhouseCoopers International Limited, independent registered public accounting firm for the Registrant |
|            |   |                                                                                                                                                                                                 |
| 15.6(6)         |   | Purchase Agreement entered into as of May 28, 2014 between the Registrant and Lincoln Park Capital Fund, LLC                                                                                         |
|            |   |                                                                                                                                                                                                 |
| 15.7(6)         |   | Registration Rights Agreement entered into as of May 28, 2014 between the Registrant and Lincoln Park Capital Fund, LLC                                                                              |
|       |

| † | Portions of this exhibit have been omitted and filed separately with the Securities and Exchange Commission pursuant to a confidential treatment request. |
|---------|-----------------------------------------------------------------------------------------------------------------------------------------------------------|

| (1) | Incorporated by reference to the Registrant's Registration Statement on Form 20-F (No. 001-35223) filed on July 1, 2011. |
|-----|--------------------------------------------------------------------------------------------------------------------------|

| (2) | Incorporated by reference to Exhibit 1 of the Registration Statement on Form F-6 (No. 333-175360) filed by the Bank of New York Mellon with respect to the Registrant's American Depositary Receipts. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (3) | Incorporated by reference to the Registrant's Form 6-K filed on February 15, 2012. |
|-----|------------------------------------------------------------------------------------|

| (4) | Incorporated by reference to the Registrant's Registration Statement on Form F-1 (No. 333-179792) filed on February 29, 2012. |
|-----|-------------------------------------------------------------------------------------------------------------------------------|

| (5) | Incorporated by reference to the Registrant's Registration Statement on Form F-3 (No. 333-205700) filed on July 16, 2015. |
|-----|---------------------------------------------------------------------------------------------------------------------------|

| (6) | Incorporated by reference to the Registrant's Form 6-K filed on May 30, 2014. |
|-----|-------------------------------------------------------------------------------|

| (7) | Incorporated by reference to the Registrant's Form 6-K filed on February 6, 2013. |
|-----|-----------------------------------------------------------------------------------|

| (8) | Incorporated by reference to the Registrant's Form 6-K filed on November 13, 2013. |
|-----|------------------------------------------------------------------------------------|

| (9) | Incorporated by reference to Amendment No. 1 to the Registrant's Annual Report on Form 20-F/A filed on May 15, 2014. |
|-----|----------------------------------------------------------------------------------------------------------------------|

| (10) | Incorporated by reference to the Registrant's Annual Report on Form 20-F filed on March 23, 2015. |
|------|---------------------------------------------------------------------------------------------------|

| (11) | Incorporated by reference to Amendment No. 2 to the Registrant's Annual Report on Form 20-F/A filed on September 22, 2015. |
|------|----------------------------------------------------------------------------------------------------------------------------|

| (12) | Incorporated by reference to the Registrant's Annual Report on Form 20-F filed on March 10, 2016. |
|------|---------------------------------------------------------------------------------------------------|

----

|               | **BIOLINERX LTD.** |                       |
|--------------------|--------------------|----------------------------|
|               |               |                       |   |
| Date: May 31, 2016 | By:                | /s/ Kinneret Savitsky |   |
|               |               | Kinneret Savitsky, Ph.D.   |   |
|               |               | Chief Executive Officer    |   |
|               |               |                       |   |

----