EX-10.14



 Exhibit 10.14 

EXECUTIVE EMPLOYMENT AGREEMENT 

THIS EXECUTIVE EMPLOYMENT AGREEMENT (“Agreement”), effective April 1, 2015 (“Effective Date”), is
made between Trillium Therapeutics USA Inc., a Delaware corporation (“Employer” or the “Company”), a subsidiary of Trillium Therapeutics Inc. (the “Parent Company”) and Eric L. Sievers (“Executive”). Executive
and the Company are sometimes referred to herein as the “Parties.” 
 RECITALS 

A. Employer and the Parent Company are in the business (the “Business”) of developing innovative therapies for the
treatment of cancer for sales, marketing and distribution world-wide. 
 B. Employer desires to obtain the services of
Executive as its Chief Medical Officer, and Executive desires to accept such full-time employment. 
 C. This Agreement is
contingent on the following: establishment of the Company as a legal entity in the United States of America; proof of right to work in the United States; and proof of right to travel to and work in Canada. 

AGREEMENT 
 NOW,
THEREFORE, in consideration of the mutual covenants herein contained, and other good and valuable consideration, the sufficiency and receipt of which are hereby acknowledged, the Parties agree as follows: 

1. Employment. 

a. Employer hereby employs Executive, and Executive agrees to be employed as Chief Medical Officer, in
accordance with the terms and conditions set forth in this Agreement. Executive will report initially to Niclas Stiernholm, the Chief Executive Officer of Employer. Changes may be made from time to time by Employer in its sole discretion to the
duties, authorities, reporting relationships and title of Executive. 
 b. Executive will devote full time,
attention, and reasonable efforts to achieving the purposes and discharging the responsibilities indicated on Exhibit A to this Agreement. Executive will comply with all rules, policies and procedures of Employer as modified from time to time.
Executive will perform all of Executive’s responsibilities in compliance with all applicable laws and will use reasonable efforts to ensure that the operations that Executive manages are in compliance with all applicable laws. During
Executive’s employment, Executive will not engage in any other business activity which, in the reasonable judgment of the Employer, conflicts with the duties of Executive under this Agreement, whether or not such activity is pursued for gain,
profit or other pecuniary advantage. 







 2. Term of Employment. The term of employment (“Term”) will not
be for a definite period, but rather continue indefinitely until terminated in accordance with the terms and conditions of this Agreement. 

3. Compensation and Stock Options. For the duration of Executive’s employment hereunder, the Executive will be
entitled to compensation which will be computed and paid pursuant to the following subsections. 
 a.
Base Salary. Employer will pay to Executive, via direct deposit, a base salary (“Base Salary”) at an annual rate of Three Hundred Seventy Five Thousand United States Dollars (USD $375,000), payable in such installments (but in no
event less than monthly), subject to withholdings and deductions as required or permitted by law (including, without limitation, withholdings or deductions required by Canadian law for employees performing services in Canada), as is Employer’s
policy with respect to other employees. Executive’s Base Salary will be reviewed periodically and may be increased in the sole discretion of Employer based on such review, but will not be reduced by Employer. 

b. Incentive Bonus. Executive will also be eligible for an annual bonus (the “Bonus”) of up
to thirty five percent (35%) of the Base Salary, based on the performance of the Parent Company, according to annual corporate objectives, which shall be paid by Employer within 60 days from the end of the applicable calendar year. Executive
may also participate in other bonus or incentive plans adopted by Parent Company that are applicable to Executive’s position, as they may be changed from time to time, but nothing herein shall require the adoption or maintenance of any such
plan. 
 c. Stock Options. Upon the execution of this Agreement, the Parent Company will propose to
the Board of Directors of the Parent Company (the “Board”) to grant Executive stock options to purchase 85,000 shares of the Parent Company’s Common Stock, one third of which to vest upon date of grant and the remainder to vest
equally on the next four anniversaries of the date of grant, pursuant and subject to the Parent Company’s Stock Option Plan. 

4. Other Benefits. 

a. Vacation. Executive will be entitled to accrued paid vacation of four (4) weeks each calendar
year, to be scheduled at times that are mutually acceptable to Executive and the Company. Executive’s paid vacation for the calendar year 2015 will be prorated to 1.67 days per each month of service from the Effective Date through the end of
the calendar year 2015. 
 b. Health and Welfare Benefits. Until such time as the Company offers
health and welfare benefits to its U.S. employees, Executive’s monthly salary will be increased by $2000, less withholdings. Executive hereby acknowledges that he will not be eligible to participate in any group health, welfare, life insurance
or other plans maintained by the Parent Company. 







 c. Expenses. Employer will reimburse Executive in
accordance with company policies and procedures for reasonable expenses necessarily incurred in the performance of duties hereunder against appropriate receipts and vouchers indicating the specific business purpose for each such expenditure. 

d. Right of Set-off. By accepting this Agreement, Executive consents to a deduction from any amounts
Employer owes Executive from time to time (including amounts owed to Executive as wages or other compensation, fringe benefits, or vacation pay, as well as any other amounts owed to Executive by Employer), to the extent of the amounts Executive owes
to Employer. Whether or not Employer elects to make any set-off in whole or in part, if Employer does not recover by means of set-off the full amount Executive owes it, calculated as set forth above, Executive agrees to pay immediately the unpaid
balance to Employer. 
 5. Termination By Employer. 

a. For Cause. Employer will have the right to immediately terminate Executive’s services and this
Agreement for Cause. “Cause” means any of the following has occurred: 
 (i) any material breach of
Sections 7, 8, 9 and 10 of this Agreement by Executive; 
 (ii) any other material breach of this Agreement
by Executive that continues unremedied for a period of thirty (30) days after written notice to Executive by Employer; 

(iii) any failure to perform assigned job responsibilities that continues unremedied for a period of thirty
(30) days after written notice to Executive by Employer; 
 (iv) Executive’s deliberate malfeasance
or willful misconduct in connection with Executive’s duties hereunder or any intentional act or omission of Executive which is materially injurious to the financial condition or business reputation of the Company, the Parent Company or any
subsidiary or affiliate of the Company or the Parent Company; 
 (v) conviction of a felony or failure to
contest prosecution for a felony; or 
 (vi) the engagement by Executive in unethical practices, dishonesty
or disloyalty. 







 Upon termination of Executive’s employment hereunder for
Cause or upon the death or disability of Executive, Executive will have no rights to any unvested benefits or any other compensation or payments after the termination date or the last day of the month in which Executive’s death or disability
occurred, other than (i) Executive’s earned but unpaid Base Salary through the date of termination, (ii) any accrued but unpaid vacation time through the date of termination, (iii) any unreimbursed expenses under
Section 4(c) hereof, or (iv) such other benefits, compensation or payments as are mandated by applicable law. For purposes of this Agreement, “disability” means the incapacity or inability of Executive, whether due to accident,
sickness or otherwise, as determined by a medical doctor acceptable to the Board and confirmed in writing by such doctor, to perform the essential functions of Executive’s position under this Agreement, with or without reasonable accommodation
(provided that no accommodation that imposes undue hardship on Employer will be required) for a period of ninety (90) consecutive days or for an aggregate of ninety (90) days during any period of twelve (12) months, or such longer
period as may be required under disability law. 
 b. Without Cause. Employer may terminate
Executive’s employment under this Agreement without cause, advance notice or severance pay during the first six months of employment (the “Review Period”). After the Review Period, Employer may terminate Executive’s employment
under this Agreement without cause and without advance notice; provided, however, that Employer will pay, in addition to the amounts specified in Section 5(a) above, as severance pay (the “Severance Pay”),
Executive’s Base Salary at the rate in effect on the termination date through the date that is twelve (12) months from the termination date (“Payment Period”). Beginning on the Termination Date and continuing through the Payment
Period, Executive agrees to use reasonable efforts to seek other employment and to take other reasonable actions to mitigate the amounts payable under this Section 5(b). If Executive obtains other employment or earns compensation during the
Payment Period, such earnings shall be offset against the severance pay described in this Section 5(b). For purposes of this Section 5(b), Executive agrees to promptly inform the Company regarding his employment status (and any changes
thereto) and the amount of any compensation he earns during the Payment Period. Executive’s obligation to mitigate shall cease on the tenth anniversary of the Effective Date of the Agreement. Executive shall only be entitled to such Severance
if, within thirty (30) days following the date of termination, Executive executes (and then Executive does not rescind, as may be permitted by law) a general release of claims in a form reasonably acceptable to the Company. Such payments of
Base Salary will be at usual and customary pay intervals of Employer, in each case subject to all appropriate deductions and withholdings. Upon termination, Executive will have no rights to any unvested benefits or any other compensation or payments
except as stated in this Section 5(b). 
 6. Termination By Executive. Executive may terminate Executive’s
employment under this Agreement for any reason provided that Executive gives 







 
Employer at least ninety (90) days’ notice in writing. Employer may, at its option, accelerate such termination date to any date at least two weeks after Executive’s notice of
termination. Employer may also, at its option, relieve Executive of all duties and authority after notice of termination has been provided. All compensation, payments and unvested benefits will cease on the termination date. 

a. Upon termination of this Agreement or upon request of the Company, Executive shall deliver to the Company
all property, documents and materials pertaining to the Company’s business including, but not limited to, memoranda, notes, records, drawings, manuals, disks, copies, representations, extracts, summaries and analyses, all inventory,
demonstration units, and any other property, documents or media of the Company, and all equipment belonging to the company, including but not limited to corporate cards, access cards, office keys, office equipment, laptop and desktop computers, cell
phones and other wireless devices, thumb drives, zip drives and all other media storage devices. 
 7. Covenant Not To
Compete. During Executive’s employment by Employer and for a period expiring twelve (12) months after the termination of Executive’s employment for any reason, Executive covenants and agrees that Executive will not: 

a. Directly, indirectly, or otherwise, own, manage, operate, control, serve as a consultant to, be employed by,
participate in, or be connected, in any manner, with the ownership, management, operation or control of any business that competes with the Business or that competes with Employer, the Parent Company or any of their affiliates, or that is engaged in
any type of business which, at any time during Employee’s employment with Employer, Employer, the Parent Company or any of their affiliates demonstrably planned to develop; 

b. Hire, offer to hire, entice away or in any other manner persuade or attempt to persuade any officer,
employee or agent of Employer, the Parent Company or any of their affiliates to alter or discontinue a relationship with Employer or the Parent Company; 

c. Directly or indirectly solicit, divert, take away or attempt to solicit, divert or take away any customers
of Employer, the Parent Company, or any of their affiliates; or 
 d. Directly or indirectly solicit, divert,
or in any other manner persuade or attempt to persuade any supplier of Employer, the Parent Company, or any of their affiliates to alter or discontinue its relationship with Employer, the Parent Company, or any of their affiliates. 

For the purposes of this Section 7, businesses that are deemed to compete with the Business, Employer the Parent Company
or any their affiliates shall be comprised only of businesses engaged in the development of cancer drugs related to the CD47 







 
pathway, or any other drugs developed by Employer or the Parent Company during Executive’s employment with the Company. The geographic scope of the prohibitions in this Section 7 shall
be worldwide. Notwithstanding Executive’s obligations under this Section 7, Executive will be entitled to own, as a passive investor, up to five percent (5%) of any publicly traded company without violating this provision. 

Employer and Executive agree that: this provision does not impose an undue hardship on Executive and is not injurious to the
public; that this provision is necessary to protect the business of Employer and its affiliates; the nature of Executive’s responsibilities with Employer under this Agreement require Executive to have access to confidential information which is
valuable and confidential to all of the Business; the scope of this Section 7 is reasonable in terms of length of time and geographic scope; and adequate consideration supports this Section 7, including consideration herein. 

8. Confidential Information. Executive recognizes that Employer’s business and continued success depend upon the
use and protection of its confidential and proprietary business information, including, without limitation, the information and technology developed by or available through licenses to Employer or the Parent Company, to which Executive has access
(all such information being “Confidential Information”). For purposes of this Agreement, the phrase “Confidential Information” includes, for Employer, the Parent Company, and their current or future subsidiaries and affiliates,
without limitation, and whether or not specifically designated as confidential or proprietary: all business plans and marketing strategies; information concerning existing and prospective markets and customers; financial information; information
concerning the development of new products and services; information concerning any personnel of Employer and the Parent Company (including, without limitation, skills and compensation information); intellectual property; and technical and
non-technical data related to software programs, designs, specifications, compilations, inventions, improvements, methods, processes, procedures and techniques; provided, however, that the phrase does not include information that
(a) was lawfully in Executive’s possession prior to disclosure of such information by Employer; (b) was, or at any time becomes, available in the public domain other than through a violation of this Agreement; (c) is documented
by Executive as having been developed by Executive outside the scope of Executive’s employment and independently; or (d) is furnished to Executive by a third party not under an obligation of confidentiality to Employer. Executive agrees
that during Executive’s employment and after termination of employment irrespective of cause, Executive will use Confidential Information only (i) while employed by the Company, in the business of and for the benefit of the Company, or
(ii) when required to do so by a court of competent jurisdiction, by any governmental agency having supervisory authority over the business of the Company, or by any administrative body or legislative body (including a committee thereof) with
jurisdiction to order Executive to divulge, disclose or make accessible such information, and then only after providing written notice to Employer that such a demand has been made. Executive’s obligation under this Agreement is in addition to
any obligations Executive has under state or federal law. Executive agrees to deliver to Employer immediately upon termination of Executive’s employment, or at any time Employer so requests, all tangible items containing any Confidential
Information (including, without 







 
limitation, all memoranda, photographs, records, reports, manuals, drawings, blueprints, prototypes, notes taken by or provided to Executive, and any other documents or items of a confidential
nature belonging to Employer), together with all copies of such material in Executive’s possession or control. Executive agrees that in the course of Executive’s employment with Employer, Executive will not violate in any way the rights
that any entity has with regard to trade secrets or proprietary or confidential information. Executive’s obligations under this Section 8 are indefinite in term and shall survive the termination of this Agreement. Executive shall also be
bound by Employer’s Non-Disclosure and Proprietary Rights Agreement which is incorporated by reference into this Agreement. 

9. Work Product and Copyrights. Executive agrees that all right, title and interest in and to the materials resulting
from the performance of Executive’s duties at Employer and all copies thereof, including works in progress, in whatever media, (the “Work”), will be and remain Employer upon their creation. Executive will mark all Work with
Employer’s copyright or other proprietary notice as directed by Employer. Executive further agrees: 

a. To the extent that any portion of the Work constitutes a work protectable under the copyright laws of the
United States (the “Copyright Law”), that all such Work will be considered a “work made for hire” as such term is used and defined in the Copyright Law, and that Employer will be considered the “author” of such portion
of the Work and the sole and exclusive owner throughout the world of copyright therein; and 
 b. If any
portion of the Work does not qualify as a “work made for hire” as such term is used and defined in the Copyright Law, that Executive hereby assigns and agrees to assign to Employer, without further consideration, all right, title and
interest in and to such Work or in any such portion thereof and any copyright therein and further agrees to execute and deliver to Employer, upon request, appropriate assignments of such Work and copyright therein and such other documents and
instruments as Employer may request to fully and completely assign such Work and copyright therein to Employer, its successors or nominees, and that Executive hereby appoints Employer as attorney-in-fact to execute and deliver any such documents on
Executive’s behalf in the event Executive should fail or refuse to do so within a reasonable period following Employer’s request. 

10. Inventions and Patents. For purposes of this Agreement, “Inventions” includes, without limitation,
information, inventions, contributions, improvements, ideas, or discoveries, whether protectable or not, and whether or not conceived or made during work hours. Executive agrees that all Inventions conceived or made by Executive during the period of
employment with Employer belong to Employer, provided they grow out of Executive’s work with Employer or are related in some manner to the Business, including, without limitation, research and product development, and projected business of
Employer or its affiliated companies. Accordingly, Executive will: 
 a. Make adequate written records of
such Inventions, which records will be Employer’s property; 







 b. Assign to Employer, at its request, any rights Executive may
have to such Inventions for the U.S. and all foreign countries; 
 c. Waive and agree not to assert any moral
rights Executive may have or acquire in any Inventions and agree to provide written waivers from time to time as requested by Employer; and 

d. Assist Employer (at Employer’s expense) in obtaining and maintaining patents or copyright registrations
with respect to such Inventions. 
 Executive understands and agrees that Employer or its designee will determine, in its
sole and absolute discretion, whether an application for patent will be filed on any Invention that is the exclusive property of Employer, as set forth above, and whether such an application will be abandoned prior to issuance of a patent. Employer
will pay to Executive, either during or after the term of this Agreement, the following amounts if Executive is sole inventor, or Executive’s proportionate share if Executive is joint inventor: $750 upon filing of the initial application for
patent on such Invention; and $1,500 upon issuance of a patent resulting from such initial patent application, provided Executive is named as an inventor in the patent. 

Executive further agrees that Executive will promptly disclose in writing to Employer during the term of Executive’s
employment, all Inventions (whether or not Employer has rights in such Inventions) so that Executive’s rights and Employer’s rights in such Inventions can be determined. Except as set forth on the initialed Exhibit B (List of Inventions)
to this Agreement, if any, Executive represents and warrants that Executive has no Inventions, software, writings or other works of authorship useful to Employer in the normal course of the Business, which were conceived, made or written prior to
the date of this Agreement and which are excluded from the operation of this Agreement. 
 NOTICE: In accordance
with Washington law, this Section 10 does not apply to Inventions for which no equipment, supplies, facility, or trade secret information of Employer was used and which was developed entirely on Executive’s own time, unless: (a) the
Invention relates (i) directly to the business of Employer or (ii) to Employer’s actual or demonstrably anticipated research or development, or (b) the Invention results from any work performed by Executive for Employer. 

11. Remedies. Notwithstanding other provisions of this Agreement regarding dispute resolution, Executive agrees that
Executive’s violation of any of Sections 7, 8, 9 or 10 of this Agreement would cause Employer irreparable harm which would not be adequately compensated by monetary damages and that an injunction may be granted by any court or courts having
jurisdiction, restraining Executive from violation of the terms of this Agreement, upon any breach or threatened breach of Executive of the 







 
obligations set forth in any of Sections 7, 8, 9 or 10. The preceding sentence shall not be construed to limit Employer from any other relief or damages to which it may be entitled as a result of
Executive’s breach of any provision of this Agreement, including Sections 7, 8, 9 or 10. 
 12. Dispute
Resolution. Except for the right of Employer and Executive to seek injunctive relief in court, any controversy, claim or dispute of any type arising out of or relating to Executive’s employment or the provisions of this Agreement shall be
resolved in accordance with this Section 12 regarding resolution of disputes, which will be the sole and exclusive procedure for the resolution of any disputes. This Agreement shall be enforced in accordance with the Federal Arbitration Act,
the enforcement provisions of which are incorporated by this reference. Matters subject to these provisions include, without limitation, claims or disputes based on statute, contract, common law and tort and will include, for example, matters
pertaining to termination, discrimination, harassment, compensation and benefits. Matters to be resolved under these procedures also include claims and disputes arising out of statutes such as the Fair Labor Standards Act, Title VII of the Civil
Rights Act, the Age Discrimination in Employment Act, the Washington Minimum Wage Act, and the Washington Law Against Discrimination. Nothing in this provision is intended to restrict Executive from submitting any matter to an administrative agency
with jurisdiction over such matter. 
 a. Mediation. Employer and Executive will make a good faith
attempt to resolve any and all claims and disputes by submitting them to mediation in King County, Washington before resorting to arbitration or any other dispute resolution procedure. The mediation of any claim or dispute must be conducted in
accordance with the then-current JAMS procedures for the resolution of employment disputes by mediation, by a mediator who has had both training and experience as a mediator of general employment and commercial matters. If the parties to this
Agreement cannot agree on a mediator, then the mediator will be selected by JAMS in accordance with JAMS’ strike list method. Within thirty (30) days after the selection of the mediator, Employer and Executive and their respective
attorneys will meet with the mediator for one mediation session of at least four hours. If the claim or dispute cannot be settled during such mediation session or mutually agreed continuation of the session, either Employer or Executive may give the
mediator and the other party to the claim or dispute written notice declaring the end of the mediation process. All discussions connected with this mediation provision will be confidential and treated as compromise and settlement discussions.
Nothing disclosed in such discussions, which is not independently discoverable, may be used for any purpose in any later proceeding. The mediator’s fees will be paid in equal portions by Employer and Executive, unless Employer agrees to pay all
such fees. 
 b. Arbitration. If any claim or dispute has not been resolved in accordance with
Section12 (a), then the claim or dispute will be determined by arbitration in accordance with the then-current JAMS employment arbitration rules and procedures, except as modified herein. The arbitration will be conducted by a sole neutral
arbitrator who has had both training and experience 







 
as an arbitrator of general employment and commercial matters and who is and for at least ten (10) years has been, a partner, a shareholder, or a member in a law firm. The arbitration shall
be held in King County, Washington. If Employer and Executive cannot agree on an arbitrator, then the arbitrator will be selected by JAMS in accordance with Rule 15 of the JAMS employment arbitration rules and procedures. No person who has served as
a mediator under the mediation provision, however, may be selected as the arbitrator for the same claim or dispute. Reasonable discovery will be permitted and the arbitrator may decide any issue as to discovery. The arbitrator may decide any issue
as to whether or as to the extent to which any dispute is subject to the dispute resolution provisions in Section 12 and the arbitrator may award any relief permitted by law. The arbitrator must base the arbitration award on the provisions of
Section 12 and applicable law and must render the award in writing, including an explanation of the reasons for the award. Judgment upon the award may be entered by any court having jurisdiction of the matter, and the decision of the arbitrator
will be final and binding. The statute of limitations applicable to the commencement of a lawsuit will apply to the commencement of an arbitration under Section 12(b). The arbitrator’s fees will be paid in equal portions by Employer and
Executive, unless Employer agrees to pay all such fees. 
 13. Fees Related to Dispute Resolution. Unless otherwise
agreed, the prevailing party will be entitled to its costs and attorneys’ fees incurred in any litigation or dispute relating to the interpretation or enforcement of this Agreement. 

14. 409A. It is intended that any payment or benefit that is provided pursuant to or in connection with this Agreement
that is considered to be deferred compensation subject to Section 409A of the Internal Revenue Code of 1986, as amended (“Code”) shall be paid and provided in a manner, and at such time and form, as complies with the applicable
requirements of Section 409A of the Code to avoid the unfavorable tax consequences provided therein for non-compliance. It is further intended that the payments hereunder shall, to the maximum extent permissible under Section 409A of the
Code, be exempt from Section 409A of the Code under either (i) the exception for involuntary separation pay to the extent that all payments are payable within the limitations described in Treasury Regulation Section 1.409A-1(b)(9), or
(ii) the short-term deferral exception described in Treasury Regulation Section 1.409A-1(b)(4) to the extent that all payments are payable no later than two and a half months after the end of the first taxable year in which the right to
the payment is no longer subject to a substantial risk of forfeiture. 
 a. If the Executive is a
“specified employee” for purposes of Section 409A(a)(2)(B)(i) of the Code at such time, any payments to be made or benefits to be delivered in connection with the Executive’s “Separation from Service” (as defined below)
that constitute deferred compensation subject to Section 409A of the Code shall not be made until the later of (i) eighteen months following the Effective Date or (ii) six months plus one day after the Executive’s Separation from
Service (the “409A Deferral Period”) as required by Section 409A of the Code, provided that the payment of any such deferred compensation 







 
may be paid immediately following the Executive’s death. Payments of any such deferred compensation otherwise due to be made in installments or periodically during the 409A Deferral Period
shall be accumulated and paid in a lump sum as soon as the 409A Deferral Period ends, and the balance of the payment shall be made as otherwise scheduled. 

b. For purposes of this Agreement, all rights to payments and benefits hereunder shall be treated as rights to
receive a series of separate payments and benefits to the fullest extent allowed by Section 409A of the Code. 

c. For purposes of this Agreement, with respect to the timing of any amounts that constitute deferred
compensation subject to Section 409A of the Code that depends on termination of employment or separation from service, termination of employment or separation from service shall mean a “separation from service” within the meaning of
Section 409A of the Code where it is reasonably anticipated that no further services would be performed after such date or that the level of bona fide services the Executive would perform after that date (whether as an employee or independent
contractor) would permanently decrease to a level less than or equal to twenty percent (20%) of the average level of bona fide services the Executive performed over the immediately preceding thirty-six (36) month period. 

15. Disclosure. Executive agrees fully and completely to reveal the terms of this Agreement to any future employer or
potential employer of Executive and authorizes Employer, at its election, to make such disclosure. 
 16. Representation
of Executive. Executive represents and warrants to Employer that Executive is free to enter into this Agreement and has no contract, commitment, arrangement or understanding to or with any party that restrains or is in conflict with
Executive’s performance of the covenants, services and duties provided for in this Agreement, and is not contravene the terms of any statute, law, or regulation to which Executive is subject. Executive agrees to indemnify Employer and to hold
it harmless against any and all liabilities or claims arising out of any unauthorized act or acts by Executive that, the foregoing representation and warranty to the contrary notwithstanding, are in violation, or constitute a breach, of any such
contract, commitment, arrangement or understanding. 
 17. Conditions of Employment. Employer’s obligations to
Executive under this Agreement are conditioned upon Executive’s ability to obtain the necessary Canadian visa for work-related travel to and work in Canada, and timely compliance with requirements of the United States and Canadian immigration
laws. 
 18. Assignability. During Executive’s employment, this Agreement may not be assigned by either party
without the written consent of the other; provided, however, that Employer may assign its rights and obligations under this Agreement without Executive’s consent to a successor by sale, merger or liquidation, if such successor carries on the
Business substantially in the form in which it is being conducted at the 







 
time of the sale, merger or liquidation. This Agreement is binding upon Executive, Executive’s heirs, personal representatives and permitted assigns and on Employer, its successors and
assigns. 
 19. Notices. Any notices required or permitted to be given hereunder are sufficient if in writing and
delivered by hand, by facsimile, by registered or certified mail, postage prepaid, or by overnight courier, to Executive at Executive’s home address at: 1137 36th Avenue, Seattle, WA 98122, or as most recently updated in Executive’s Human
Resources records, or to the Company c/o the Chief Executive Officer of Trillium Therapeutics, Inc., 96 Skyway Avenue, Toronto, ON, M9W 4Y9. Notices shall be deemed to have been given (i) upon delivery, if delivered by hand, (ii) seven
days after mailing, if mailed, (iii) one business day after delivery, if delivered by courier, and (iv) one business day following receipt of an appropriate electronic confirmation, if by facsimile. 

20. Severability. If any provision of this Agreement or compliance by any of the parties with any provision of this
Agreement constitutes a violation of any law, or is or becomes unenforceable or void, then such provision, to the extent only that it is in violation of law, unenforceable or void, shall be deemed modified to the extent necessary so that it is no
longer in violation of law, unenforceable or void, and such provision will be enforced to the fullest extent permitted by law. The Parties shall engage in good faith negotiations to modify and replace any provision which is declared invalid or
unenforceable with a valid and enforceable provision, the economic effect of which comes as close as possible to that of the invalid or unenforceable provision which it replaces. If such modification is not possible, said provision, to the extent
that it is in violation of law, unenforceable or void, shall be deemed severable from the remaining provisions of this Agreement, which provisions will remain binding on the parties. 

21. Waivers. No failure on the part of either party to exercise, and no delay in exercising, any right or remedy
hereunder will operate as a waiver thereof; nor will any single or partial waiver of a breach of any provision of this Agreement operate or be construed as a waiver of any subsequent breach; nor will any single or partial exercise of any right or
remedy hereunder preclude any other or further exercise thereof or the exercise of any other right or remedy granted hereby or by law. 

22. Governing Law. Except as provided in Section 12 above, the validity, construction and performance of this
Agreement shall be governed by the laws of the State of Washington without regard to the conflicts of law provisions of such laws. The King County Superior Court, Seattle, Washington shall have exclusive jurisdiction of any lawsuit arising from or
relating to Executive’s employment with, or termination from, Employer, or arising from or relating to this Agreement. Executive consents to such venue and personal jurisdiction. 

23. Counterparts. This agreement may be executed in counterpart in different places, at different times and on
different dates, and in that case all executed counterparts taken together collectively constitute a single binding agreement. 







 24. Costs and Fees Related to Negotiation and Execution of Agreement. Each
Party shall be responsible for the payment of its own costs and expenses, including legal fees and expenses, in connection with the negotiation and execution of this Agreement. Neither Party will be liable for the payment of any commissions or
compensation in the nature of finders’ fees or brokers’ fees, gratuity or other similar thing or amount in consideration of the other Party entering into this Agreement to any broker, agent or third party acting on behalf of the other
Party. 
 25. Entire Agreement. This instrument contains the entire agreement of the parties with respect to the
relationship between Executive and Employer and supersedes all prior agreements and understandings, and there are no other representations or agreements other than as stated in this Agreement related to the terms and conditions of Executive’s
employment. This Agreement may be changed only by an agreement in writing signed by the party against whom enforcement of any waiver, change, modification, extension or discharge is sought, and any such modification will be signed by an authorized
representative of Employer. 
 IN WITNESS WHEREOF, the parties have duly signed and delivered this Agreement as of
the day and year first above written. 
  

			
	 EMPLOYER

		
	 By
		  

	 Title:
		  

	
	 EXECUTIVE

	
	  

	
	
Print Name:                          
                                         










 EXHIBIT A 

INITIAL DUTIES AND RESPONSIBILITIES 

JOB SUMMARY: 
 The Chief
Medical Officer is a key member of the senior management team providing medical expertise in the decisions affecting the company’s clinical development programs in support of Trillium’s corporate goals. The Chief Medical Officer will
oversee the Company’s team of clinical, medical and regulatory staff, consultants and advisors. The position involves regular written and verbal summaries of findings and communication to the executive team. This position reports to the Chief
Executive Officer. 
 MAJOR RESPONSIBILITIES: 
  

	 	 •
	 	 Develop clinical trial strategies and oversee all clinical development activities 



 

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	 	 Lead all interactions with regulatory authorities 


  

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	 	 Lead the assembly and submission of the first SIRPaFc IND, and phase I trial design and execution 



 

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	 	 Direct a multidisciplinary team including staff, collaborators and external contract resources to manage the Company’s medical, clinical and
regulatory activities. 


  

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	 	 Build and maintain relationships with KOLs, hospitals, clinical sites, CROs and partners. 



 

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	 	 Serve as the clinical lead for advisory meetings. 


  

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	 	 Assist in defining corporate strategy with respect to technology, clinical, regulatory and medical strategy. 



 

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	 	 Ensure adherence to FDA, HC, and pertinent clinical and regulatory standards. 



 

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	 	 Perform medical monitoring and reporting for all clinical activities. 



 

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	 	 Review analysis and documentation of clinical results. 


  

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	 	 Work effectively with the R&D team in supporting corporate goals. 



 

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	 	 Plan and budget all clinical and regulatory activities. 


  


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	 	 Monitor competitive clinical and regulatory activity and developments. 



 

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	 	 Reporting and presentation of program and data to internal and external supervisory and ethics boards, regulatory bodies, third party
collaborators, and the scientific community. 


  

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	 	 Conduct critical analysis of potential market opportunities from a clinical standpoint and be able to communicate such analysis.










 ADDITIONAL RESPONSIBILITIES: 

 

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	 	 Keep abreast of the competitive landscape and assist with the conduct of due diligence on competitive and complementary technologies/products.



  

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	 	 Assist with communication of clinical development plans to potential and existing investors. 



 

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	 	 Support business development activities. 



MINIMUM QUALIFICATIONS: 

Technical Knowledge/Experience 
  

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	 	 MD degree with a specialty in oncology and hematology preferred 



 

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	 	 Minimum of 10 years of medical/ clinical related industry experience 



 

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	 	 Strong background in oncology and hematology 


  

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	 	 Demonstrated leadership centered on the ability to develop an overall clinical development strategy 



 

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	 	 Extensive clinical development experience with biologic drug development (all clinical phases) 



 

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	 	 Comprehensive understanding of clinical regulatory requirements, and knowledge of all relevant guidelines 



 

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	 	 Ability to work in a small biotech company environment, interact across multiple disciplines, and manage outside consultants 



 

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	 	 Excellent organizational and communication skills 


  

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	 	 Supervisory experience 



Behavioral 
 Demonstrated
ability to apply the following behavioral competencies on the job: 
  

	 	 •
	 	 Leadership: Effectively manage, coach and mentor staff 



 

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	 	 Teamwork: Working effectively and productively with others 



 

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	 	 Written Communication: Writing clearly, succinctly and understandably 



 

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	 	 Problem Solving: Anticipating, analyzing, diagnosing and resolving problems 



 

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	 	 Organization and Planning: Utilizing logical, systematic and orderly procedures to meet objectives 



 

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	 	 Flexibility: Agility in adapting to change 



WORKING CONDITIONS: 
  

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	 	 Ability to work independently 


  

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	 	 Regular travel to Toronto office, industry events and meetings with stakeholders is expected (a minimum of 8-10 times a year)










 EXHIBIT B 

LIST OF INVENTIONS