COOING FORM FOR SRC INDEXING

Micrcfir:ho No.

. OTS0522945

REVISED 10115/86

REPORT ON THE STUDY OF THE ACUTE ORAL TOXICITY OF

HEXABROMOCYCLODODECANE IN THE MOUSE WITH COVER LETTER DATED

031290

HEXABROMOCYCLODODECANE (3194-55-5)

..
Attention: 8(d) Health & safety

Reporting Rule Notification

·U. S. Environmental Protection Agency

Document Processing Center (TS-790)

Office of Toxic Substances

401 M Street, sw

Washington, DC 20460

BASF Corporation

Certified Mail

Return Receipt Requested

March 12, 1990

Ladies and Gentlemen:

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Subject: Health & Safety Study Reporting

54 Federal Register 51114, December 12, 1989

25th ITC Report

In response to the TSCA reporting rule referenced above, BASF

Corporation is subm~tting the attached studies on:

CAS Reg. No.

1163-19-5

3194-55-6

32534-81-9

32536-52-0

DECABROMODIPHENYLETHER

Decabromodiphenyl Ether

Hexabromocyclododecane

Pentabromodiphenyl Ether

Octabromodiphenyl Ether

CAS REG. NO. 1163-19-5

1. Bericht uber Versuche zur Ermittlung der mittleren todlichen

Dosen funf verschiedener verbindungen, 10.03.1976

2. Ames Metabolic Activation Test to Assess the Potential

Mutagenic Effect of Bromkal 82-0 DE, 08.n.1978

3. Ames Metabolic Activation Test to Assess the Potential

Mutagenic Effect of Muster 83, 17.10.1984

4. Ames Metabolic Activation Test to Assess the Potential

Mutagenic Effect of Muster 88, 16.10.1984

5. Final Report. 14-Day Repeated Dose Feeding Study - Mice,

13.11.1978

6. Final Report. 14-Day Repeated Dose Feeding Study - Rats,

14.11.1978

7. 90-Day Subchronic Feeding Study in Rats on Dec~bromo(fphenyl

Oxide, 27.07.1979

1609 Biddle Avenue. Wyandotte, Michigan 48192 (313) 246-6100
Page 2

U. S. Environmental Protection Agency

DECABROMODIPHENYLETHER CAS REG. NO. 1163-19-5 (Cont.)

B. 90-Day Subchronic Feeding Study in Rats on Decabromodiphenyl

Oxide, 27.07.1979

9. Results of 30-Day Rat Dietary Feeding Studies on Octabromobiphenyl SA-1902 and Decabromodiphenyl Oxide SA-1892.1,

2B.01.1971 c

10. Ergebnisbericht uber Untersuchungen ZUl.' Bildung von Po1ybromdibenzofuranen und -dioxinen wahrend der Extrusion von

Polybutandio1-terephthalat (PBTP)i Flammschutzmittel: Decabromodiphenylether

11. Untersuchung zur Bildung von Polybrom-dibenzofuranen und

dioxinen bei der Extrusion von Po1y-Butanedio1-terephthalat

(PBTP)i Flamrnschutzmittel: Decabrom-diphenyletheri Tei1 2;

Produktionsanlage

HEXABROMOCYCLODODECANE CAS REG. NO. 3194-55-6

1. prufungsbericht uber die toxikologischen Untersuchungen mit

Hexabromocyclododecan der Firma Chemische Fctbrik Kalk GmbH,

Koln-Kalk an Laboratoriumstieren, 04.10.1971

2. Bericht uber die Prufung der akuten Toxizitat an der Go1-

dorfe (Leuciscus idus L., Goldvariante), 1B.03.1988

3. Ames Test for Hexabromid S, 24.04.1978

4. Hexabromocyclododecane: 28-day feeding trials with rats

(with Germany summary - 17.11.1969)

5. Hexabromocyclododecant 90·,day feeding trials with rats (with

Germany summary 04.02.1970)

6. Report on the study of the irritation of Hexabromocyclododecane to the dorsal skin of rabbits after 20-hour exposure,

04.10.1962

7. Report on the study of the primary irritation of Hexabromocyclododecane to the eye of rabbits, 04.10.1962

8. Report on the study of the acute oral toxicity of Hexabromocyclododecane in the mouse, 04.10.1962

9. Notiz: ALD 50; Ratte, oral, 28.11.1962

10. Ames metaholic activation test to assess the potenti~l

mutagenic effect of compound No. 49, 19.09.1978 '
Page 3

U. S. Environmental Protection Agency

HEXABROMOCYCLODODECANE CAS REG. NO. 3194-55-6 (Cont.)

11. Migration von HECD aus geschaumtern"Polystyrol, 27.06.8~

12. Migration von Flarnmschutzmitteln aus geschaurntem Polystyrol

08.08.85, 19.12.85, 28.08.86

13. APME: Expandable Polystyrene Information Dossier, p 18 with

Data to Aquatic toxicity and Bioaccurnulation (log Pow a.o.),

March 1988

14. Algal Growth Inhibition Test, 1990/01/31

15. Determination of the acute toxicity of Hexabrornid S to the

waterflea Daphnia magna Straus, 1990/01/30

16. Oxygen Consumption Test (using Pseudomonas putida by the

test method of Robra), 1989/04/19

17. Biologische Abbau Tests, 1980/05/06, 1981/10/16

PENTABROMODIPHENYLETHER CAS REG. NO. 32534-81-9

1. Prufung der akuten Toxizitat au der Goldorfe, 13.02.1984

2. Toxicologische Prufung von Fenta-brom-diphenylaether

3. Prufung von Bromkal 70-5 DE im Augenreiztest am Kaninchen,

January 1981

4. Prufung von Bromkal 70-5 DE im Hautreiztest'am Kaninchen,

January 1981

5. Ames metabolic activation t~st to assess the potential

mutagenic effect of Bromkal 70-5 DE, 08.02.1978

OCTABROMODIPHENYLETHER CAS REG •.;:NO. 32536-52-0

1. Bericht uber Ve.rsuche zur Ermittlung der Vertraglichkeit von

Bromkal 82-0DE-Ruckstand, Brorokal 79-BDE:"lliedrigschmelzend

und Brornkal 79-8DE-Ruckstand, 04.09.1984

2. Ames metabolic activation test to assess the potential

mutagenic effect of Muster 84, 12.10.1984

3. Ames metabolic activation test to assess the potential

mutagenic effect of Muster 82, 30.10.1984
Page 4

u: S. Environmenta:i Protection Agency

OCTABROMODIPHENYLETHER CAS REG .. NO~ 32536-52-0

4.

5.

6.

Ames metabolic activation test to assess the potential

mutagenic effect of Muster 13, 15.05.1978

Prufung von Bromkal 79-8 DE im Augenre.iztest am Kaninchen,

June 1980

Prufung von Bromkal 79-8 DE im Hautreiztest am Kaninchen,

June 1980

submitting Site:

7. Bericht uber Versuche zur Ermittlung der mittleren todlichen

Dosen funf verschiedener Verbindungen, 10.03.1976

8. Bericht uber Versuche z~r Ermittlung der mittleren todlichen

Dosis von Bromkal 79-8 DE, 21.05.1976

BASF Corporation

8 Campus Drive

Parsippany, NJ 07054

Submitting Official: Roberta A. Hurley

Sr. Product Regulations Specialist

BASF Corporation

1609 Biddle Avenue

Wyandotte, MI 48192-3799

Telephone: (313) 246-6214

Please contact me at 313-246-6214 if you have any questions.

Very truly yours,

BASF CORPORATION

Roberta

V(oJMJ.A~ A. Hurley

Sr. Product Regulatio s Specialist

mk

Ene.
BASF Aktiengesellschaft

Abteilung Toxlkologie

Department Toxicology

:().6700 Ludwigshafen

'0JntJa~ fl'v

fOOi\ITAINS;'NO CBI

.APR 171985 */by-dd; 4211

Sheet 1

000688456·

~-90000D~~3

the acute oral toxicity of HexabroBocyc1o31 q~ '" s)".. ,~& EPA-aTa

~~~~ il~~~III~I~~ XII/252; Mouse/oral

Report on the study o~

dodecane in the mouse

Testing facility: BASF Aktiengesellschaft

Department of Toxicology

D-6700 Ludwigshafen/Rhein

Aim of the study: Estimate of the potential acute hazard

after single oral administration (determination of the ALDSO)

Test substance No.: XII!252

Name of test substance: Hexabromocyclododecane

A detailed product characterization ia included in the raw data.

* The original report of Oct. 4, 1962 is printed in German.

It was translated into English a~d reprinted in respect to the

reporting and evaluation standard of 1985. based on the raw data

of 1962.

Dieses Dokument enthalt Betriebs- und Geschaftsgeheimnissa

der BASF. Es ist Eigentum der BASF und dar! nur %u dem von.

8ASF vorgesehenen Zwack verwendet werden. Jede andere oder

daruber hinausgehende Verwendung, Verwertur.g. Weitergabe.

Vervielfaltigung oder Veroffenllichung bedar! der Einwilligung derBASF. .

This document contains manufacturing and trade secrets of

BASF. It is the j)rOpel'ty of BASF and may be used only f.or;~hat

purpose for which it was intended by BASF. Every other or,

additional use. exploitation. reproduction, publicationor ..

•SUbmission to other parties require the written permis.sion : of.B~SF,' .. .. ... . ...
. XII!252; Mouse/oral

ACUTE ORAL TOXICITY

Test 8ubstanc. No.:

Name of test substance:

Form of administrati~n:

Route of administration:

Observation period:

Examinations:

RESULT

Toxikologie

Sheet 2

XII/252

Hexabromocyclododecane

The product was administered to the

animals once by gavage as a ~O% aqueous

tragacanth suspension.

Oral

7 days

a) Determination of the approximative -

median lethal dose (ALD 50)

b) Signs of toxicit~

c) Necropsy of the animals sacrificed

by carbon dioxide at the end of the

observation period.

ALD 50 (mouse, oral): > 6,400 mg/kg body weight
XII/252; Mouse/oral

ACUTE ORAL TOXICITY

SIGNS:

Increasing apathy, trembling. Late mortalities!

Dr.med.vet. Schulze

NECROPSY FINDINGS:

Peritonitis. Product is not fully resorbed.

Dr.med.vet. Schulze

Responsible for correct translation:

.~

Toxlkologie

Sheet :5

t~~~'t fJrp",. II, letcg5

B.E. Byrt, B.A.