### SAT Report PMN Number: P-08-0733 SAT Date: 9/30/2008 Print Date: 3/21/2011

Related cases : CBI : Yes Health related cases: P08-0734 Ecotox related cases:

Concern levels : Type of Concern: Health Eco Comments Level of Concern: 1-2 1

Persistence Bioaccum Toxicity Comments 3 U2

Exposure Based Review : Health: N o Ecotox: N o
Routes of exposure : Health: Inhalation, dermal, and drinking water. Ecotox: N o releases to water Fate: ; Keywords : Keywords: LUNG IMMUNO UNCERT-ONCO-LUNG
Summary of Assessment :

Fate : Fate Summary: P-08-0733-34 FATE: Solid with MP = Dec 500-600 EC (E) S < 0.001 mg/L at 25 EC (E) VP < 1.0E-6 torr at 25 EC (E) BP > 400 EC (E) H < 1.00E-8 (E) POTW removal (%) = U via U Time for complete ultimate aerobic biodeg = U Sorption to soils/sediments = U PBT Potential: P3BU*CEB FATE: Migration to ground water = U

Health : Health Summary: Absorption is poor all routes based on analogs. The PMN materials are multi-walled carbon nanotubes. There is concern for lung overload if respirable p articles are inhaled and uncertain concern for cancer if inhaled. There is also concern for immunotoxicity. Low moderate concern. Test Data: negative in Salmonella and E coli (both materials were tested) negative for chromosome aberrations in CHL cells (both materials were tested) acute oral study in rats - no deaths or signs of toxicity at 2000 mg/kg (both materials tested) not a dermal irritant (P08-0733) very slight skin irritant (P08-0734) not a dermal sensitizer in guinea pigs (both materials were tested) 4-hr nose-only inhalation study in rats - 1 of 10 died at 1.87 mg/l, increased respiratory rate, labored respiration, noisy respiration, hunched posture, p iloerection, fur staining by test material, wet fur (P08-0733) 4-hr nose-only inhalation study in rats - no deaths at 1.65 mg/l, increased respiratory rate, hunched posture, p iloerection, fur staining by test material, wet fur, abnormally dark lungs with p atches intratracheal administration of 0.2 mg/animal once a week for 6 weeks in hamsters animals were then kept for 2 years after first administration of test material (group 1 - vehicle alone; group 2 - test substance alone; group 3 - test substance plus benzo[a] p yrene; group 4 - test substance plus chrysotile and benzo[a[] p yrene) no deaths, crouching position, sedation, decreased body weight, suppressed body weight gain; carcinogenicity of test material is weak (no tumors in group 2)

Ecotox :

Test Organism Test Type Test End Point Predicted Measured Comments

fish 96-h LC50 * daphnid 48-h LC50 * green algal 96-h EC50 * fish

_ chronic value * daphnid

_ chronic value * algal

_ chronic value * Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value

_ Ecotox Values Comments: Predictions are based on SARs for neutral organic chemicals; SAR chemical class = -multi-walled carbon nanotubes; MW>1,000,000; solid; log Kow >> 10 (P); S = negligible; p H7; effective concentrations based on 100% active ingredients and nominal concentrations; DW hardness < 150.0 mg/L as CaCO3; and DW TOC <2.0 mg/L;Factors Values Comments Assessment Factor 10 Concentration of Concern ( p pb) *

SARs SAR Class

Ecotox Factors Comments:

SAT Chair: Becky Jones