EXHIBIT 10.19

ALZA Corporation
Amended and Restated Executive Deferral Plan II
2000 Amendment 1

     ALZA Corporation, a Delaware corporation (the "Company"),
pursuant to the power granted to it by Section 10.2 of the ALZA
Corporation Amended and Restated Executive Deferral Plan II, as
amended (the "Plan"), hereby amends the Plan, as follows,
effective as of February 8, 2000.

1.   Section 1.21 is amended in its entirety to read as follows:

     ""Retirement" and "Retire" shall mean termination of
     employment or severance of directorship with the
     Company (i) on or after the attainment of age sixty-two
     (62), (ii) at a time when Years of Service are equal to
     or greater than 20, (iii) at a time when the sum of age
     at last birthday plus Years of Service equal 62 or more
     ("Rule of 62") or (iv) within two years after a Change
     in Control, provided the Participant was an employee or
     director at the time of the Change in Control."  If a
     Participant is both an employee and a Director,
     Retirement shall not occur until he or she retires as
     both an employee and a Director.

2.   Section 10.1 is amended in its entirety to read as follows:

     "Plan Termination.  The Company reserves the right to
     terminate the Plan at any time, subject to the payout of
     benefits as set forth below.  Upon termination of the Plan,
     the Participants' then existing EDP II Accounts, including
     the Secondary Account Balance and all interest earned
     through the date of such termination, shall be paid out as
     if each Participant Retired on the date of termination based
     on the most recent payout election made by the Participant
     in accordance with Article 5 above.  If the Plan is
     terminated prior to a Change in Control, the Company
     reserves the right, at its sole discretion and
     notwithstanding any elections made by the Participant, to
     pay such benefits in a lump sum or in annual installments
     for up to 15 years, with interest credited on the unpaid
     balance at the Preferred Distribution Rate.  The termination
     of the Plan shall not adversely affect any Participant or
     Beneficiary who has become entitled to the payment of any
     benefits under the Plan as of the date of termination."

3.   Section 10.2 is amended in its entirety to read as follows:

     "Amendment or Modification.  The Company may, at any time,
     amend or modify the Plan in whole or in part; provided,
     however, that no amendment or modification shall have the
     effect of decreasing or restricting any EDP II Account
     balance, calculated as if (a) the Participant experienced a
     Termination of Employment as of the effective date of the
     amendment or modification, or (b) if the Participant was
     eligible to Retire on the effective date of the amendment or
     modification, or if such amendment or modification is made
     after a Change in Control, calculated as if the Participant
     had Retired as of the effective date of the amendment or
     modification.  The amendment or modification of the Plan
     shall have no effect on any Participant or Beneficiary who
     has become entitled to the payment of benefits under the
     Plan as of the date of the amendment or modification."

4.   Except as expressly provided herein, the provisions of the
     Plan will continue in their entirety as set forth immediately
     prior to the effective date of this amendment.

     The Company has caused this Amendment to be signed by its
duly authorized officer as of the date written below.

                              ALZA Corporation, a Delaware Corporation

                              By: David R. Hoffmann

                              Its: Vice President, Treasurer

                              Date: February 8, 2000