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                                                                   EXHIBIT 10.16


                              EMPLOYMENT AGREEMENT



         THIS AGREEMENT, made effective as of this 1st day of January, 2001, by
and between STEVEN A. GOULD, M.D. ("Employee") and NORTHFIELD LABORATORIES INC.,
a Delaware corporation (the "Company").

                              W I T N E S S E T H :

         WHEREAS, Employee is now employed as the President of the Company;

         WHEREAS, the Company and Employee now desire to enter into this
Agreement in order to continue such employment for the term set forth herein and
subject to the terms and conditions set forth herein; and

         WHEREAS, the Company and Employee desire to continue the Proprietary
Information and Inventions Agreement entered into by and between Employee and
the Company dated September 1, 1985 (the "Proprietary Information and Inventions
Agreement") in full force and effect;

         NOW, THEREFORE, in consideration of the premises, and of the mutual
covenants hereinafter set forth, the parties do hereby agree as follows:

         1. Employment. The Company agrees to employ Employee, and Employee
agrees to remain in the employ of the Company, for the period (the "Employment
Period") beginning on January 1, 2001 and ending on the earlier to occur of (a)
December 31, 2002 or (b) the date as of which Employee's employment is
terminated pursuant to paragraph 5 of this Agreement. During the Employment
Period, Employee shall serve as the President of the Company and shall perform
such executive and managerial duties consistent with such position as the Chief
Executive Officer and the Board of Directors of the Company shall from time to
time direct. Employee shall devote his full business time and attention to the
business of the Company and its subsidiaries.

         2. Location. Employee shall be based at the Company's headquarters in
Evanston, Illinois, or at such other location as may be agreed upon by Employee
and the Board of Directors of the Company. Employee shall, however, also travel
to other locations at such times as may be reasonably required for the
performance of his duties under this Agreement; provided that the frequency and
duration of such travel shall not be substantially greater than the frequency
and duration of Employee's travel during his employment by the Company prior to
the date of this Agreement.



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         3. Compensation. During the Employment Period, Employee shall be
compensated as follows:

                  (a) Salary. An "Employment Year" shall be the twelve-month
         period beginning on the first day of the Employment Period and on each
         anniversary of such date during the Employment Period. For the first
         Employment Year, Employee shall be paid an annual base salary at a rate
         which is not less than $294,973 per year. For the second Employment
         Year, Employee shall be paid an annual base salary at a rate which is
         not less than $303,822 per year. Employee's base salary shall be paid
         in equal, semi-monthly installments.

                  (b) Bonus. Employee shall be paid a cash bonus of $147,486 as
         of the date the Company files a Biologic License Application for its
         PolyHeme blood substitute product with the United States Food and Drug
         Administration. Employee shall be paid an additional cash bonus of
         $294,973 as of the date the Company is granted approval for the
         commercial sale of PolyHeme in the United States for any indication.
         The Board of Directors of the Company may in its discretion determine
         to award Employee additional cash bonuses from time to time during the
         term of this Agreement.

                  (c) Award of Stock Options. On January 1, 2001, the Company
         awarded Employee stock options under the Northfield Laboratories Inc.
         1999 Stock Option Plan to acquire 15,000 shares of the Company's Common
         Stock at an exercise price per share equal to the fair market value of
         the Company's Common Stock as of the date of grant. On or before
         January 1, 2002, the Compensation Committee of the Board of Directors
         of the Company shall review the performance of the Company and
         Executive during the first Employment Year and shall determine whether
         the award of additional stock options to Employee is appropriate. The
         Board of Directors of the Company may in its discretion determine to
         award Employee additional stock options or other forms of equity
         incentive compensation from time to time during the term of this
         Agreement.

                  (d) Paid Vacation. Employee shall be entitled to five weeks
         paid vacation in each calendar year. Any vacation which is not used by
         Employee shall be forfeited at the end of the calendar year.

                  (e) Expenses. Employee shall be reimbursed for all reasonable
         business expenses incurred in the performance of his duties pursuant to
         this Agreement, to the extent such expenses are substantiated and are
         consistent with the general policies of the Company and its
         subsidiaries relating to the reimbursement of expenses of senior
         executive officers.





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                  (f) Fringe Benefits. In addition to any other compensation
         provided under this Agreement, Employee shall also be entitled to
         participate, during the Employment Period, in any and all pension,
         stock option, relocation, profit sharing, and other employee benefit
         plans or fringe benefit programs which are from time to time maintained
         by the Company or its subsidiaries for their senior executive officers,
         in accordance with the provisions of such plans or programs as from
         time to time in effect.

                  (g) Deduction and Withholding. All compensation and other
         benefits payable to or on behalf of Employee pursuant to this Agreement
         shall be subject to such deductions and withholding as may be agreed to
         by Employee or required by applicable law.

         4. Other Benefits. The compensation provisions of this Agreement shall
be in addition to, and not in derogation or diminution of, any benefits that
Employee or his beneficiaries may be entitled to receive under the provisions of
any pension, stock option, profit sharing, disability (except as otherwise
provided in subparagraph 6(b)), relocation or other employee benefit plan now or
hereafter maintained by the Company or by any of its subsidiaries. The Company
shall not make any changes in such plans or arrangements which would adversely
affect Employee's rights or benefits thereunder, unless such change is made
uniformly in a plan of general application to all of the Company's or a
subsidiary's eligible employees.

         5. Termination. Employee's employment may be terminated without any
breach of this Agreement only under the following circumstances:

                  (a) Death. Employee's employment shall terminate upon his
         death.

                  (b) Disability. If, as a result of Employee's incapacity due
         to physical or mental illness or accident, (i) Employee shall have been
         absent from his duties for the Company on a full-time basis for the
         entire period of six consecutive months and (ii) within thirty days
         after written Notice of Termination is given (which may occur before or
         after the end of such six-month period) shall not have returned to the
         performance of his duties, the Company may terminate Employee's
         employment for "disability."

                  (c) Cause. The Company may terminate Employee's employment
         hereunder for "cause." For purposes of this Agreement, "cause" shall
         mean the conviction of Employee of any felony or any failure by
         Employee to comply in all material respects with any material term of
         this Agreement or the Proprietary Information and Inventions Agreement
         which conduct or failure is materially injurious to the Company,
         monetarily or otherwise. Notwithstanding the foregoing, Employee shall
         not be deemed to have been terminated for cause without (i) at least 60
         days prior written notice from the Company to Employee setting forth
         the reasons for the Company's intention to terminate for cause, (ii) an
         opportunity to cure the stated cause during the 60-day notice period,
         and (iii) after all of the preceding procedures have been satisfied or
         made available, delivery to Employee


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         of a Notice of Termination from the Board of Directors of the Company
         finding that in the good faith opinion of such Board of Directors,
         Employee was guilty of the conduct or of the failure described in the
         second sentence of this subparagraph, specifying the particulars in
         detail, and that Employee has failed to cure the stated cause.

                  (d) Termination by Employee. Employee may voluntarily
         terminate his employment at any time. Employee's termination of
         employment shall be for "good reason" if he voluntarily terminates his
         employment:

                           (i) within 90 days after a "change in control" (as
                  defined below) of the Company for any reason;

                           (ii) at any time after a "change in control" of the
                  Company because:

                                    (A) he has been reassigned to a position of
                           lesser rank or status or to a location other than
                           Evanston, Illinois (or such other location as
                           Employee may agree), without his consent; or

                                    (B) his annual base salary has been reduced;
                           or

                                    (C) his benefits have been reduced;

                           (iii) because of a failure by the Company to comply
                  with any material provision of this Agreement which has not
                  been cured within ten days after written notice of such
                  noncompliance has been given by the Employee to the Company;
                  or

                           (iv) because of any purported termination of the
                  Employee's employment by the Company which is not effected
                  pursuant to a Notice of Termination satisfying the
                  requirements of subparagraph 5(e) hereof (and for purposes of
                  this Agreement no such purported termination shall be
                  effective).

                  For purposes of this Agreement, a "change in control" shall
         mean a change in control of the Company of a nature that would be
         required to be reported in response to Item 1(a) of the Current Report
         on Form 8-K, as in effect as of the date of this Agreement, promulgated
         pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934,
         as amended (the "Exchange Act"), whether or not the Company is then
         subject to the reporting requirements of the Exchange Act; provided
         that, without limitation, such a change in control shall be deemed to
         have occurred if:

                           (i) there shall be consummated any sale, lease,
                  exchange or other transfer (in one transaction or a series of
                  related transactions) of all or substantially all of the
                  Company's assets;






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                           (ii) the stockholders of the Company approve any plan
                  or proposal of liquidation or dissolution of the Company;

                           (iii) there shall be consummated any consolidation or
                  merger of the Company in which the Company is not the
                  surviving or continuing corporation, or pursuant to which
                  shares of the Company's Common Stock would be converted into
                  cash, securities or other property, other than a merger of the
                  Company in which the holders of the Company's Common Stock
                  immediately prior to the merger have, directly or indirectly,
                  at least an 80% ownership interest in the outstanding Common
                  Stock of the surviving corporation immediately after the
                  merger;

                           (iv) any "person" or "group" (as such terms are used
                  in Section 13(d) and 14(d) of the Exchange Act) becomes the
                  "beneficial owner" (as defined in Rule 13d-3 under the
                  Exchange Act), directly or indirectly, of securities of the
                  Company representing 15% or more of the combined voting power
                  of the Company's then outstanding voting securities ordinarily
                  having the right to vote for the election of directors;

                           (v) individuals who, as of the date of this
                  Agreement, constitute the Board of Directors of the Company
                  (the "Board" generally, and as of the date hereof, the
                  "Incumbent Board") cease for any reason to constitute a
                  majority of the Board; provided that any individual becoming a
                  director subsequent to the date of this Agreement whose
                  election, or nomination for election by the Company's
                  stockholders, was approved by a vote of at least
                  three-quarters of the directors comprising the Incumbent Board
                  shall be, for purposes of this Agreement, considered as though
                  such individual were a member of the Incumbent Board; provided
                  further that, notwithstanding the foregoing, an individual
                  whose initial assumption of office as a director is in
                  connection with any actual or threatened "solicitation" of
                  "proxies" (as such terms are defined in Rule 14a-1 of
                  Regulation 14A promulgated under the Exchange Act) by any
                  "person" or "group" (as such terms are used in Section 13(d)
                  and 14(d) of the Exchange Act) other than the Incumbent Board
                  shall not be considered as a member of the Incumbent Board for
                  purposes of this Agreement; or

                           (vi) the Board fails to nominate Employee for
                  election as a director in connection with any annual or
                  special meeting of the Company's stockholders at which
                  directors are to be elected (Employee having indicated his
                  willingness to be nominated as a director and to serve as a
                  director if elected), Employee is nominated for election as a
                  director in connection with any annual or special meeting of
                  the Company's stockholders at which directors are to be
                  elected (Employee having indicated his willingness to serve as
                  a director if elected) but is not elected as a director by the
                  Company's stockholders at such meeting, or Employee is removed
                  from office as a director, with or without cause, by vote or
                  consent of the Company's stockholders, if, in each case, such
                  event occurs






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                  in connection with any actual or threatened "solicitation" of
                  "proxies" (as such terms are defined in Rule 14a-1 of
                  Regulation 14A promulgated under the Exchange Act) by any
                  "person" or "group" (as such terms are used in Section 13(d)
                  and 14(d) of the Exchange Act) other than the Incumbent Board.

                  (e) Notice of Termination. Any termination of Employee's
         employment by the Company or by Employee (other than termination
         because of Employee's death) shall be communicated by written Notice of
         Termination to the other party hereto. For purposes of this Agreement,
         a "Notice of Termination" shall mean a notice which shall indicate the
         specific termination provision of this Agreement relied upon and shall
         set forth in reasonable detail the facts and circumstances claimed to
         provide a basis for termination of Employee's employment under the
         provision so indicated.

                  (f) Date of Termination of Employment. "Date of Termination"
         shall mean (i) if Employee's employment is terminated by his death, the
         date of his death; (ii) if Employee's employment is terminated for
         disability pursuant to subparagraph 5(b) above, 30 days after Notice of
         Termination is given (provided that Employee shall not have returned to
         the performance of his duties during such thirty-day period); (iii) if
         Employee's employment is terminated for any other reason, the date
         specified in the Notice of Termination which shall not be less than 10
         days nor more than 60 days from the date Notice of Termination is
         given; provided that if within 30 days after any Notice of Termination
         is given the party receiving such Notice of Termination notifies the
         other party that a dispute exists concerning the termination, the Date
         of Termination shall be the date on which the dispute is finally
         determined, either by mutual written agreement of the parties, by a
         binding and final arbitration award or by a final judgment, order or
         decree of a court of competent jurisdiction (the time for appeal
         therefrom having expired and no appeal having been perfected).

         6. Compensation Upon Termination of Employment or During Disability.

                  (a) Death. If Employee's employment is terminated by his
         death, the Company shall continue to pay his full base salary at the
         rate then in effect to Employee's surviving spouse or, if he has no
         surviving spouse, to his estate as a death benefit for a period of one
         month following his Date of Termination.

                  (b) Disability. During any period that Employee fails to
         perform his duties hereunder as a result of incapacity due to physical
         or mental illness or accident, the Company shall continue to pay him
         his full base salary at the rate then in effect for such period until
         his Date of Termination and shall pay him any bonus that becomes
         payable prior to his Date of Termination. Notwithstanding the preceding
         sentence any salary payments made to Employee during such period of
         incapacity shall be reduced (but not below zero) by amounts actually
         paid to the Employee for the same period and at or prior to the time of
         any such salary payment under disability benefit plans maintained by
         the Company; provided such



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         disability benefit amounts were not previously applied to reduce any
         such salary payment.

                  (c) Cause. If Employee's employment is terminated for cause,
         the Company shall pay Employee his full base salary through the Date of
         Termination at the rate in effect at the time Notice of Termination is
         given and, except for other compensation or benefits accrued through
         his Date of Termination, the Company shall have no further obligations
         to Employee under this Agreement except as otherwise required by
         applicable law.

                  (d) Breach; Termination for Good Reason. If (i) in breach of
         this Agreement, the Company shall terminate Employee's employment other
         than pursuant to subparagraphs 5(a), 5(b) or 5(c) hereof (it being
         understood that a purported termination pursuant to subparagraphs 5(b)
         or 5(c) hereof which is disputed and finally determined not to have
         been proper shall be a termination of Employee's employment by the
         Company in breach of this Agreement) or (ii) Employee shall terminate
         his employment for good reason, then:

                           (i) the Company shall make a lump sum payment to
                  Employee, not later that five business days after the Notice
                  of Termination is given by the Company or Employee, as
                  applicable, in an amount equal to two times Employee's highest
                  annual base salary as in effect at any time during the twelve
                  months preceding the date such Notice of Termination is given;

                           (ii) the Company shall pay to Employee, not later
                  than five business days after the date they become due and
                  payable, any bonus that would have been payable to Employee
                  pursuant to subparagraph 3(b) had Employees employment with
                  the Company continued through the expiration of the Employment
                  Period;

                           (iii) if the termination of Employee's employment
                  occurs after the date of a change in control of the Company,
                  any stock options held by Executive that did not become fully
                  vested and exercisable as of the date of such change in
                  control shall become fully vested and exercisable as of the
                  Date of Termination; and

                           (iv) until the second anniversary of the date the
                  Notice of Termination is given by the Company or Employee, as
                  applicable, Employee shall continue to be eligible to
                  participate in any accident, health, disability, life or
                  similar employee welfare benefit plans maintained by the
                  Company or its subsidiaries, to the same extent he was
                  eligible to participate in such plans at any time during the
                  twelve months preceding the date such Notice of Termination is
                  given and at no cost to him; provided that if such continued
                  participation is precluded by the provisions of such plans or
                  by applicable law, the Company shall provide Employee with
                  comparable benefits of equivalent value.





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                  Employee understands and agrees that if he materially breaches
         any material provision of the Proprietary Information and Inventions
         Agreement, the Company shall cease to have any obligation to make any
         payment under this subparagraph 6(d).

                  (e) Voluntary Termination. If Employee voluntarily terminates
         his employment other than for good reason, he shall not be entitled to
         receive any compensation or benefits pursuant to this Agreement, other
         than compensation or benefits accrued through the Date of Termination
         or as otherwise required by law.

                  (f) Post-Employment Period Severance. If Employee's employment
         with the Company terminates at any time after December 31, 2002 for any
         reason other than Employee's death, disability or discharge for cause
         and an "employment offer" (as defined below) by the Company is not
         outstanding as of the date of the termination of Employee's employment,
         then the Company shall continue to pay Employee his full base salary,
         at a rate equal to the rate in effect immediately prior to December 31,
         2002, until December 31, 2004. If Employee's employment with the
         Company terminates at any time after December 31, 2002 for any reason
         other than Employee's death, disability or discharge for cause and an
         "employment offer" by the Company is outstanding as of the date of the
         termination of Employee's employment, then the Company shall continue
         to pay Employee his full base salary, at a rate equal to the rate in
         effect immediately prior to December 31, 2002, until December 31, 2003.
         An "employment offer" shall be deemed to be outstanding as of the date
         of the termination of Employee's employment with the Company if, as of
         such date, there is outstanding a written offer by the Company to enter
         into an employment agreement with Employee in substantially the form of
         this Agreement providing for a term of employment ending on or after
         December 31, 2004 and an annual base salary at least equal to
         Employee's base salary in effect immediately prior to December 31,
         2002. The Company shall notify Employee in writing at least 30 days
         prior to the expiration of the Employment Period as to whether the
         Company plans to extend an employment offer to Employee. Employee shall
         not be entitled to receive any severance payments under this
         subparagraph 6(f) if Employee and the Company enter into an employment
         or severance agreement after the date of this Agreement (including any
         renewal or extension of this Agreement) that includes severance
         arrangements relating to the termination of Employee's employment with
         the Company after December 31, 2002. Employee understands and agrees
         that if he materially breaches any material provision of the
         Proprietary Information and Inventions Agreement, the Company shall
         cease to have any obligation to make any severance payments under this
         subparagraph. Employee further understands and agrees that the payments
         to be made to Employee pursuant to this Section 6(f) may be applied by
         the Company to satisfy its payment obligations set forth in Section 5
         of the Proprietary Information and Inventions Agreement for the period
         during which payments are being made to Employee in accordance with
         this Section 6(f).






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                  (g) Mitigation. Employee shall not be required to mitigate the
         amount of any payment provided for this paragraph 6 by seeking other
         employment or otherwise, nor shall the amount of any payments provided
         in this Agreement be reduced by any compensation earned by Employee as
         the result of his self-employment or his employment by another employer
         after his Date of Termination.

         7. Excise Tax Payments.

                  (a) Right to Receive Gross-Up Payment. In the event that any
         payment or benefit (within the meaning of Section 280G(b)(2) of the
         Internal Revenue Code of 1986, as amended (the "Code")) to Employee or
         for Employee's benefit paid or payable or distributed or distributable
         pursuant to the terms of this Agreement or otherwise in connection
         with, or arising out of, Employee's employment with the Company or a
         change in ownership or effective control of the Company or of a
         substantial portion of its assets (a "Payment"), would be subject to
         the excise tax imposed by Section 4999 of the Code, or any interest or
         penalties are incurred by Employee with respect to such excise tax
         (such excise tax, together with any such interest and penalties, are
         hereinafter collectively referred to herein as the "Excise Tax"), then
         Employee shall be entitled to receive an additional payment (a
         "Gross-Up Payment") in an amount such that after payment by Employee of
         all taxes (including any interest or penalties imposed with respect to
         such taxes and the Excise Tax, other than interest and penalties
         imposed by reason of Employee's failure to file timely a tax return or
         pay taxes shown due on Employee's return, and including any Excise Tax
         imposed upon the Gross-Up Payment), Employee retains an amount of the
         Gross-Up Payment equal to the Excise Tax imposed upon the Payments.

                  (b) Determination Relating to Gross-Up Payment. An initial
         determination as to whether a Gross-Up Payment is required pursuant to
         this Agreement and the amount of such Gross-Up Payment shall be made at
         the Company's expense by an accounting firm of recognized national
         standing selected by the Company and reasonably acceptable to Employee
         (the "Accounting Firm"). The Accounting Firm shall provide its
         determination (the "Determination"), together with detailed supporting
         calculations and documentation, to the Company and Employee within five
         days of the Date of Termination, if applicable, or such other time as
         requested by the Company or by Employee (provided Employee reasonably
         believes that any of the Payments may be subject to the Excise Tax). If
         the Accounting Firm determines that no Excise Tax is payable by
         Employee with respect to a Payment or Payments, it shall furnish
         Employee with an opinion reasonably acceptable to Employee that no
         Excise Tax shall be imposed with respect to any such Payment or
         Payments. The Gross-Up Payment, if any, as determined pursuant to this
         subparagraph 7(b) shall be paid by the Company to Employee within five
         days after the receipt of the Determination. Within ten days after the
         delivery of the Determination to Employee, Employee shall have the
         right to dispute the Determination (the "Dispute"). The existence of
         the Dispute shall not




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         in any way affect Employee's right to receive the Gross-Up Payment in
         accordance with the Determination. If there is no Dispute, the
         Determination shall be binding, final and conclusive upon the Company
         and Employee, subject to the application of the provisions of
         subparagraph 7(c).

                  (c) Excess Payment and Underpayment. As a result of
         uncertainty in the application of Sections 280G and 4999 of the Code,
         it is possible that a Gross-Up Payment (or a portion thereof) shall be
         paid which should not be paid (an "Excess Payment") or that a Gross-Up
         Payment (or a portion thereof) which should be paid shall not be paid
         (an "Underpayment"). An Underpayment shall be deemed to have occurred
         (i) upon notice (formal or informal) to Employee from any governmental
         taxing authority that Employee's tax liability (whether in respect of
         Employee's current taxable year or in respect of any prior taxable
         year) may be increased by reason of the imposition of the Excise Tax on
         a Payment or Payments with respect to which the Company has failed to
         make a sufficient Gross-Up Payment, (ii) upon a determination by a
         court, (iii) by reason of a determination by the Company (which shall
         include the position taken by the Company, together with its
         consolidated group, on its federal income tax return) or (iv) upon the
         resolution of the Dispute to Employee's satisfaction. If an
         Underpayment occurs, Employee shall promptly notify the Company and the
         Company shall promptly, but in any event at least five days prior to
         the date on which the applicable government taxing authority has
         requested payment, pay to Employee an additional Gross-Up Payment equal
         to the amount of the Underpayment plus any interest and penalties
         (other than interest and penalties imposed by reason of Employee's
         failure to file timely a tax return or pay taxes shown due on
         Employee's return) imposed on the Underpayment. An Excess Payment shall
         deemed to have occurred upon a Final Determination (as hereinafter
         defined) that the Excise Tax shall not be imposed upon a Payment or
         Payments (or portion thereof) with respect to which Employee had
         previously received a Gross-Up Payment. A "Final Determination" shall
         be deemed to have occurred when Employee has received from the
         applicable government taxing authority a refund of taxes or other
         reduction in Employee's tax liability by reason of the Excise Payment
         and upon either (i) the date a determination is made by, or an
         agreement is entered into with, the applicable governmental taxing
         authority which finally and conclusively binds Employee and such taxing
         authority, or in the event that a claim is brought before a court of
         competent jurisdiction, the date upon which a final determination has
         been made by such court and either all appeals have been taken and
         finally resolved or the time for all appeals has expired or (ii) the
         statute of limitations with respect to Employee's applicable tax return
         has expired. If an Excess Payment is determined to have been made, the
         amount of the Excess Payment shall be treated as a loan by the Company
         to Employee and Employee shall pay to the Company on demand (but not
         less than 10 days after the determination of such Excess Payment and
         written notice has been delivered to Employee) the amount of the Excess
         Payment plus interest at an annual rate equal to the Applicable Federal
         Rate provided for in Section 1274(d) of the Code from the date the
         Gross-Up Payment (to which the Excess Payment relates) was paid to
         Employee until the date of repayment to the Company.





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                  (d) Payment of Excise Tax Withholding. Notwithstanding
         anything contained in this Agreement to the contrary, in the event
         that, according to the Determination, an Excise Tax is imposed on any
         Payment or Payments, the Company shall pay to the applicable government
         taxing authorities as Excise Tax withholding the amount of the Excise
         Tax that the Company has actually withheld from the Payment or
         Payments.

         8. Successors; Binding Agreement.

                  (a) Successors to the Company. The Company shall require any
         successor (whether direct or indirect, by purchase, merger,
         consolidation or otherwise) to all or substantially all of the business
         and/or assets of the Company, by agreement in form and substance
         satisfactory to Employee, to expressly assume and agree to perform this
         Agreement in the same manner and to the same extent that the Company
         would be required to perform it if no such succession had taken place.
         Failure of the Company to obtain such agreement prior to the
         effectiveness of any such succession shall be a breach of this
         Agreement and shall entitle Employee to terminate his employment with
         the Company for good reason. As used in this Agreement, "Company" shall
         mean the Company and any successor to its business and/or assets which
         executes and delivers the agreement provided for in this paragraph 8 or
         which otherwise becomes bound by all the terms and provisions of this
         Agreement by operation of law.

                  (b) Assignment. Employee's rights and interests under this
         Agreement may not be assigned, pledged or encumbered by him without the
         Company's written consent. This Agreement and all rights of Employee
         hereunder shall inure to the benefit of and be enforceable by
         Employee's personal or legal representatives, executors,
         administrators, successors, heirs, distributees, devisees and legatees.
         If Employee should die while any amounts would still be payable to him
         hereunder if he had continued to live all such amounts, unless
         otherwise provided herein, shall be paid in accordance with the terms
         of this Agreement to Employee's surviving spouse or, if there is no
         surviving spouse, to his estate.

         9. Proprietary Information. Employee and the Company have entered into
the Proprietary Information and Inventions Agreement, which agreement shall
remain in full force and effect.

         10. Payment of Costs and Indemnification.

                  (a) Payment of Costs. In the event that a dispute arises
         regarding termination of Employee's employment or the interpretation or
         enforcement of this Agreement, the Company shall promptly pay, or
         reimburse to Employee, as and when incurred, all reasonable fees and
         expenses (including reasonable legal fees and expenses, court costs,
         costs of investigation and similar expenses) incurred by Employee in
         contesting or disputing any such termination, in seeking to obtain or
         enforce any right or benefit provided for in this Agreement, or in
         otherwise pursuing his claim; provided, however, that the Company shall
         be entitled to




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         recover from Employee the amount of any such fees and expenses paid by
         the Company if the Company obtains a final judgment in its favor on the
         merits of such dispute from a court of competent jurisdiction from
         which no appeal may be taken, whether because the time to do so has
         expired or otherwise.

                  (b) Indemnification. The Company shall indemnify and hold
         Employee harmless to he maximum extent permitted by law against
         judgments, fines, amounts paid in settlement and reasonable expenses,
         including attorneys' fees, incurred by Employee in connection with the
         defense of, or as a result of, any action or proceeding (or any appeal
         from any action or proceeding) in which Employee is made or is
         threatened to be made a party by reason of the fact that Employee is or
         was an employee, officer, or director of the Company or any of its
         subsidiaries, regardless of whether such action or proceeding is one
         brought by or in the right of the Company to procure a judgment in its
         favor. The undertaking of subparagraph (a) above is independent of, and
         shall not be limited or prejudiced by, the undertakings of this
         subparagraph (b). The indemnification provided in this Agreement is in
         addition to, and not in derogation of, any rights to indemnification or
         advancement of expenses to which Executive may otherwise be entitled
         under the Certificate of Incorporation or Bylaws of the Company, any
         indemnification contract or agreement, any policy of insurance or
         otherwise.

                  (c) Warranty. The Company hereby represents and warrants that
         the undertakings of payment and indemnification set out in (a) and (b)
         above are not in conflict with the Certificate of Incorporation or
         Bylaws of the Company or with any validly existing agreement or other
         proper corporate action of the Company.

         11. Registration Rights.

                  (a) Demand Registration. Upon the terms and subject to the
         conditions set forth in this paragraph 11, Employee or his estate or
         legal representative may request a single registration (the "Demand
         Registration") under the Securities Act of 1933, as amended (the
         "Securities Act"), of all or part of the shares of the Company's Common
         Stock beneficially owned by Employee or his estate (collectively, the
         "Registrable Securities").

                  (b) Demand Priority. The Company shall not include in the
         Demand Registration any securities which are not Registrable Securities
         without the prior written consent of Employee or his estate or legal
         representative. If the Demand Registration is an underwritten offering
         and the managing underwriters advise the Company that in their opinion
         the number of Registrable Securities and, if permitted hereunder, other
         securities requested to be included in such offering exceeds the number
         of Registrable Securities and other securities which can be sold in an
         orderly manner in such offering within a price range acceptable to
         Employee or his estate or legal representative, the Company shall
         include in such registration prior to the inclusion of any securities
         which are not Registrable Securities the number of Registrable
         Securities requested to be included which in the opinion of







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<PAGE>   13

         such underwriters can be sold in an orderly manner within the price
         range of such offering.

                  (c) Postponement Right. The Company may postpone for up to 90
         days the filing or the effectiveness of a registration statement for
         the Demand Registration if the Board of Directors of the Company
         determines in good faith that such Demand Registration would reasonably
         be expected to have an adverse effect on any proposal or plan by the
         Company to engage in any acquisition of assets (other than in the
         ordinary course of business), merger, consolidation or tender offer or
         to enter into any material license agreement, joint venture arrangement
         or similar transaction; provided that in such event, the holders of
         Registrable Securities shall be entitled to withdraw such request and,
         if such request is withdrawn, such Demand Registration shall not count
         as the permitted Demand Registration hereunder and the Company shall
         pay all registration expenses in connection with such registration in
         accordance with subparagraph 11(h).

                  (d) Piggyback Registrations. Whenever the Company proposes to
         register any of its securities under the Securities Act (other than
         pursuant to a Demand Registration) and the registration form to be used
         may be used for the registration of Registrable Securities (a
         "Piggyback Registration"), the Company shall give prompt written notice
         to Employee of its intention to effect such a registration and shall
         include in such registration all Registrable Securities with respect to
         which the Company has received written requests for inclusion therein
         within 15 days after the giving of the Company's notice.

                  (e) Piggyback Priority on Company Registrations. If a
         Piggyback Registration is an underwritten primary registration on
         behalf of the Company, and the managing underwriters advise the Company
         in writing that in their opinion the number of securities requested to
         be included in such registration exceeds the number which can be sold
         in an orderly manner in such offering within a price range acceptable
         to the Company, the Company shall include in such registration (i)
         first, the securities the Company proposes to sell, (ii) second, the
         Registrable Securities and any other securities requested to be
         included in such registration by holders entitled to registration
         rights in connection therewith, pro rata among such holders based on
         the number of shares requested to be included in such registration, and
         (iii) third, other securities requested to be included in such
         registration

                  (f) Piggyback Priority on Secondary Registrations. If a
         Piggyback Registration is an underwritten secondary registration on
         behalf of holders of the Company's securities, and the managing
         underwriters advise the Company in writing that in their opinion the
         number of securities requested to be included in such registration
         exceeds the number which can be sold in an orderly manner in such
         offering within a price range acceptable to the holders initially
         requesting such registration, the Company shall include in such
         registration (i) first, the securities requested to be included therein
         by the holders requesting such registration and the Registrable
         Securities requested to be included therein by the holders thereof, pro
         rata among such holders based on the number of shares requested to be
         included in




                                       13
<PAGE>   14

         such registration, and (ii) second, other securities requested to be
         included in such registration.

                  (g) Best Efforts by the Company. Whenever the holders of
         Registrable Securities have requested that any Registrable Securities
         be registered pursuant to this Agreement, the Company shall use its
         reasonable best efforts to effect the registration and the sale of such
         Registrable Securities in accordance with the intended method of
         disposition.

                  (h) Registration Expenses. The Company shall pay all expenses
         incident to the registration and disposition of the Registrable
         Securities pursuant to this Agreement, including all registration,
         filing and applicable securities exchange fees, all fees and expenses
         of complying with state securities or blue sky laws (including fees and
         disbursements of counsel to the underwriters or the holders of
         Registrable Securities in connection with "blue sky" qualification of
         the Registrable Securities and determination of their eligibility for
         investment under the laws of the various jurisdictions), all word
         processing, duplicating and printing expenses, all messenger and
         delivery expenses, the fees and disbursements of counsel for the
         Company and of counsel for any other person reasonably requested by the
         holders of a majority of the Registrable Securities included in the
         registration, the fees and expenses of the Company's independent public
         accountants and any other independent public accountants whose opinions
         are included in the registration statement, including the expenses of
         "cold comfort" letters or any special audits required by, or incident
         to, such registration, all fees and disbursements of underwriters
         (other than underwriting discounts and commissions), all transfer
         taxes, and the reasonable fees and expenses of counsel and accountants
         to the holders of Registrable Securities; provided that the holders of
         Registrable Securities will be required to pay all underwriting
         discounts and commissions in respect of the Registrable Securities
         being registered by such holders. In connection with any registration
         pursuant to this Agreement, the Company will not be obligated to pay
         the fees and expenses for more than one counsel, other than local and
         special counsel, or for more than one firm of accountants representing
         the holders of Registrable Securities.

                  (i) Indemnification by the Company. The Company agrees to
         indemnify, to the extent permitted by law, each holder of Registrable
         Securities, its officers and directors and each person who controls
         such holder (within the meaning of the Securities Act) against all
         losses, claims, damages, liabilities and expenses caused by any untrue
         or alleged untrue statement of material fact contained in any
         registration statement, prospectus or preliminary prospectus or any
         amendment thereof or supplement thereto or any omission or alleged
         omission of a material fact required to be stated therein or necessary
         to make the statements therein not misleading, except insofar as the
         same are caused by or contained in any information furnished in writing
         to the Company by such holder expressly for use therein or by such
         holder's failure to deliver a copy of the registration statement or
         prospectus or any amendments or supplements thereto after the Company
         has furnished such holder with a sufficient number of copies of the
         same. In






                                       14
<PAGE>   15

         connection with an underwritten offering, the Company shall indemnify
         such underwriters, their officers and directors and each person who
         controls such underwriters (within the meaning of the Securities Act)
         to the same extent as provided above with respect to the
         indemnification of the holders of Registrable Securities.

                  (j) Indemnification by Holders. In connection with any
         registration statement in which a holder of Registrable Securities is
         participating, each such holder shall furnish to the Company in writing
         such information and affidavits as the Company reasonably requests for
         use in connection with any such registration statement or prospectus
         and, to the extent permitted by law, shall indemnify the Company, its
         directors and officers and each person who controls the Company (within
         the meaning of the Securities Act) against any losses, claims, damages,
         liabilities and expenses resulting from any untrue or alleged untrue
         statement of material fact contained in the registration statement,
         prospectus or preliminary prospectus or any amendment thereof or
         supplement thereto or any omission or alleged omission of a material
         fact required to be stated therein or necessary to make the statements
         therein not misleading, but only to the extent that such untrue
         statement or omission is contained in any information or affidavit so
         furnished in writing by such holder; provided that the obligation to
         indemnify shall be individual to each holder and shall be limited to
         the net amount of proceeds received by such holder from the sale of
         Registrable Securities pursuant to such registration statement.

                  (k) Limitations on Exercise. The registration rights provided
         in this paragraph 11 shall be exercisable only after the occurrence of
         a change in control of the Company.

         12. General Provisions.

                  (a) Fees and Expenses. The Company shall pay as they become
         due all legal fees and related expenses (including the costs of
         experts) incurred by Employee as a result of (i) Employee's termination
         of employment (including all such fees and expenses, if any, incurred
         in contesting or disputing any such termination of employment) and (ii)
         Employee seeking to obtain or enforce any right or benefit provided by
         this Agreement (including any such fees and expenses incurred in
         connection with any Dispute or Gross-Up Payment, whether as a result of
         any applicable government taxing authority proceeding, audit or
         otherwise) or by any other plan or arrangement maintained by the
         Company under which Employee is or may be entitled to receive benefits.

                  (b) No Set-Off. The Company's obligation to make the payments
         provided for in this Agreement and otherwise to perform its obligations
         hereunder shall not be affected by any circumstances, including any
         right of set-off, counterclaim, recoupment, defense or other right
         which the Company may have against Employee or others.




                                       15
<PAGE>   16

                  (c) Effect of Headings. The headings of all of the paragraphs
         and subparagraphs of this Agreement are inserted for convenience of
         reference only and shall not affect the construction or interpretation
         of this Agreement.

                  (d) Modification, Amendment, Waiver. No modification,
         amendment, or waiver of any provision of this Agreement shall be
         effective unless approved in writing by both parties. The failure at
         any time to enforce any of the provisions of this Agreement shall in no
         way be construed as a waiver of such provisions and shall not affect
         the right of either party thereafter to enforce each and every
         provision of this Agreement in accordance with its terms.

                  (e) Severability. Whenever possible, each provision of this
         Agreement shall be interpreted in such manner as to be effective and
         valid under applicable law, but if any provision of this Agreement
         shall be held to be prohibited by or invalid under applicable law, such
         provision shall be ineffective only to the extent of such prohibition
         or invalidly, without invalidating the remainder of such provision or
         the remaining provisions of this Agreement.

                  (f) No Strict Construction. The language used in this
         Agreement shall be deemed to be the language chosen by the parties
         hereto to express their mutual intent, and no rule of strict
         construction shall be applied against any person.

                  (g) Choice of Law. All questions concerning the construction,
         validity and interpretation of this Agreement shall be governed by the
         internal laws of the State of Illinois.

                  (h) Notices. Any notice to be served under this Agreement
         shall be in writing and shall be mailed by registered mail, return
         receipt requested, addressed:

                  If to the Company, to:

                  Northfield Laboratories Inc.
                  1560 Sherman Avenue
                  Evanston, Illinois  60201-4422
                  Attention:  Board of Directors

                  If to Employee, to:

                  c/o Northfield Laboratories Inc.
                  1560 Sherman Avenue
                  Evanston, Illinois  60201-4422

                  or to such other place as either party may specify in writing,
         delivered in accordance with the provisions of this subparagraph.

                  (i) Survival. The rights and obligations of the parties shall
         survive the term of Employee's employment to the extent that any
         performance is required under this Agreement after the expiration or
         termination of such term.




                                       16
<PAGE>   17

                  (j) Entire Agreement. This Agreement, together with the
         Proprietary Information and Inventions Agreement described in paragraph
         9 above, constitutes the entire agreement of the parties with respect
         to the subject matter thereof, and supersedes all previous agreements
         between the parties relating to the same subject matter (but excluding
         the Proprietary Information and Inventions Agreement, which agreement
         shall remain in full force and effect).

                  (k) Counterparts. This Agreement may be executed in two or
         more counterparts, each of which shall be deemed an original but all of
         which shall together constitute one and the same document.



                                    * * * * *
















































                                       17
<PAGE>   18




                                    * * * * *

         IN WITNESS WHEREOF, the parties hereto have executed this Agreement
effective as of the day and year first above written.

EMPLOYEE                                            NORTHFIELD LABORATORIES INC.


/s/ Steven A. Gould, M.D.                           By
----------------------------                           -----------------------
Steven A. Gould, M.D.                               Its
                                                       -----------------------













































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