Exhibit 31
                                  CERTIFICATION

Certification of Chief Executive  Officer,  President and the person  performing
similar  functions  to the  Chief  Financial  Officer,  pursuant  to  Securities
Exchange Act rules 13a-14(a) and 15d-14(a) as adopted pursuant to Section 302 of
the Sarbanes Oxley Act of 2002.

I, Marvin Maslow, certify that:

1. I have reviewed  this annual report on Form 10-KSB of Manhattan  Scientifics,
Inc.;

2.  Based on my  knowledge,  this  annual  report  does not  contain  any untrue
statement of a material fact or omit to state a material fact  necessary to make
the statements made, in light of the  circumstances  under which such statements
were made,  not  misleading  with  respect to the period  covered by this annual
report;

3.  Based  on my  knowledge,  the  financial  statements,  and  other  financial
information  included  in this annual  report,  fairly  present in all  material
respects the financial  condition,  results of operations  and cash flows of the
small  business  issuer as of, and for,  the  periods  presented  in this annual
report;

4. I am responsible for  establishing  and maintaining  disclosure  controls and
procedures (as defined in Exchange Act Rules 13a-15 and 15d-15(e)) for the small
business issuer and have:

     a)  designed  such  disclosure   controls  and  procedures  or  cause  such
disclosure  controls and  procedures  to be designed  under my  supervision,  to
ensure  that  material  information  relating  to  the  small  business  issuer,
including its  consolidated  subsidiaries,  is made known to me by others within
those  entities,  particularly  during the period in which this annual report is
being prepared;

     b) evaluated the  effectiveness of the small business  issuer's  disclosure
controls and procedures and presented in this report our  conclusions  about the
effectiveness  of the disclosure  controls and procedures,  as of the end of the
period covered by this annual report based on such evaluation; and

     c)  disclosed  in this  annual  report  any  change in the  small  business
issuer's  internal  control over financial  reporting  that occurred  during the
small business issuer's most recent fiscal quarter that has materially affected,
or its  reasonably  likely to materially  affect,  the small  business  issuer's
internal control over financial reporting; and

5.  I  have  disclosed,  based  on my  most  recent  evaluation  over  financial
reporting,  to the small business  issuer's  auditors and the audit committee of
small business issuer's board of directors (or persons performing the equivalent
functions):

     a) all  significant  deficiencies  and  material  weakness in the design or
operation of internal  controls over  financial  reporting  which are reasonably
likely to  adversely  affect  the small  business  issuer's  ability  to record,
process, summarize and report financial information; and

     b) any fraud,  whether or not material,  that involves  management or other
employees who have a significant  role in the small business  issuer's  internal
controls over financial reporting; and



Date: April 4, 2006



/s/ Marvin Maslow
--------------------------------------
Marvin Maslow
Chief Executive Officer, President and
Principal Financial Officer