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EXHIBIT 10.2  


 
 

REGISTRATION RIGHTS AGREEMENT    
  


    THIS REGISTRATION RIGHTS AGREEMENT, dated as of January 22, 2001, between the investor or investors signatory hereto (each an "Investor" and together
the "Investors"), and Calypte Biomedical Corporation, a Delaware corporation (the "Company"). 


    WHEREAS,
simultaneously with the execution and delivery of this Agreement, the Investors are purchasing from the Company, pursuant to a Convertible Debentures and Warrants Purchase
Agreement dated the date hereof (the "Purchase Agreement") (capitalized terms not defined herein shall have the meanings ascribed to them in the Purchase Agreement), $1,100,000, in the aggregate,
principal amount of the Company's 6% Convertible Debentures; and 


    WHEREAS,
the Company desires to grant to the Investors the registration rights set forth herein with respect to the Conversion Shares of Common Stock issuable upon conversion of, or
as interest upon, the Convertible Debentures, shares of Common Stock issuable upon exercise of the Warrants purchased pursuant to the Purchase Agreement and shares issuable in the event of a
registration default pursuant to Section 3(e) (the "Securities"). 


    NOW,
THEREFORE, the parties hereto mutually agree as follows: 


    Section 1.  Registrable Securities.  As used herein the term "Registrable Security" means the
Securities until (i) the Registration Statement has been declared effective by the Commission, and all Securities have been disposed of pursuant to the Registration Statement, (ii) all
Securities have been sold under circumstances under which all of the applicable conditions of Rule 144 (or any similar provision then in force) under the Securities Act ("Rule 144") are
met, (iii) all Securities have been otherwise transferred to holders who may trade such Securities without restriction under the Securities Act, and the Company has delivered a new certificate
or other evidence of ownership for such Securities not bearing a restrictive legend or (iv) such time as, in the opinion of counsel to the Company, all Securities may be sold without any time,
volume or manner limitations pursuant to Rule 144(k) (or any similar provision then in effect) under the Securities Act. The term "Registrable Securities" means any and/or all of the securities
falling within the foregoing definition of a "Registrable Security." In the event of any merger, reorganization, consolidation, recapitalization or other change in corporate structure affecting the
Common Stock, such adjustment shall be deemed to be made in the definition of "Registrable
Security" as is appropriate in order to prevent any dilution or enlargement of the rights granted pursuant to this Agreement. 


    Section 2.  Restrictions on Transfer.  Each Investor acknowledges and understands that prior to
the registration of the Securities as provided herein, the Securities are "restricted securities" as defined in Rule 144 promulgated under the Securities Act. Each Investor understands that no
disposition or transfer of the Securities may be made by Investor in the absence of (i) an opinion of counsel to the Investor, in form and substance reasonably satisfactory to the Company, that
such transfer may be made without registration under the Securities Act or (ii) such registration. 


    With
a view to making available to the Investors the benefits of Rule 144 under the Securities Act or any other similar rule or regulation of the Commission that may at any
time permit the Investors to sell securities of the Company to the public without registration ("Rule 144"), the Company agrees to: 



    (a) comply
with the provisions of paragraph (c)(1) of Rule 144; 


    (b) file
with the Commission in a timely manner all reports and other documents required to be filed with the Commission pursuant to Section 13 or 15(d) under
the Exchange Act by companies subject to either of such sections, irrespective of whether the Company is then subject to such reporting requirements; and 


    (c) Upon
request by the Transfer Agent, the Company shall provide the Transfer Agent an opinion of counsel, which opinion shall be reasonably acceptable to the Transfer
Agent, that the 






 


Investor has complied with the applicable conditions of Rule 144 (or any similar provision then in force) under the Securities Act. 




    Section 3.  Registration Rights With Respect to the Securities.  


    (a) The
Company agrees that it will prepare and file with the Commission, prior to April 15, 2001, a registration statement (on Form S-3, or
other appropriate registration statement form) under the Securities Act (the "Registration Statement"), at the sole expense of the Company (except as provided
in Section 3(c) hereof), in respect of the Investors, so as to permit a public offering and resale of the Securities under the Act by the Investors as selling stockholders and not as
underwriters. 


    The
Company shall cause such Registration Statement to become effective within ninety (90) calendar days (or 120 calendar days in the event of a "full review" by the
Commission) from the Closing Date, or, if earlier, within five (5) days of SEC clearance to request acceleration of effectiveness. The number of shares designated in the Registration Statement
to be registered shall include all the Warrant Shares and at least 200% of the shares which would be issuable upon the conversion of the then outstanding principal amount of the Convertible Debentures
at the Conversion Price in effect on the date of the filing of the Registration Statement and such number of shares as the Company deems prudent for the purpose of issuing shares of Common Stock as
interest on the Convertible Debentures, and shall include appropriate language regarding reliance upon Rule 416 to the extent permitted by the Commission. The Company will notify the Investors
and its transfer agent of the effectiveness of the Registration Statement within one (1) Trading Day of such event. After the Effective Date, in the event that the number of shares so
registered shall prove to be insufficient to register the resale of all of the Securities then issuable (notwithstanding the limitations on conversion herein and in the Purchase Agreement), then the
Company shall be obligated to file, within fifteen (15) days after the day on which the number of Securities registered for public offering and resale by the Investors is less than 125% of the
number of Securities (calculated at the Conversion Price on such date) held by the Investors on such date (the "Further Registration Date") and the Company shall file a further registration
statement registering a number of shares of Common Stock to the extent that at least 200% of the shares which would be required to be issued upon the conversion of the remaining Convertible Debentures
at the Conversion Price on the date of the filing of such further registration statement are registered and shall use diligent best efforts to prosecute such additional registration statement to
effectiveness within sixty (60) calendar days of the date of the Further Registration Date. Each Investor shall have the right to convert all or any of its Convertible Debenture into up to a
number of registered shares of Common Stock equal to such Investor's fraction of the aggregate Purchase Price multiplied by the initially registered and, if applicable, subsequently registered
Securities; provided, however, in no event shall this provision limit each Investor's right to convert its Convertible Debenture into unregistered
Common Stock. 


    (b) The
Company will maintain the Registration Statement or post-effective amendment filed under this Section 3 effective under the Securities Act
until the earlier of (i) the date that none of the Securities covered by such Registration Statement are or may become issued and outstanding, (ii) the date that all of the Securities
have been sold pursuant to such Registration Statement, (iii) the date the Investors receive an opinion of counsel to the Company, which counsel shall be reasonably acceptable to the Investors,
that the Securities may be sold under the provisions of Rule 144 without limitation as to volume, (iv) all Securities have been otherwise transferred to persons who may trade such shares
without restriction under the Securities Act, and the Company has delivered a new certificate or other evidence of ownership for such securities not bearing a restrictive legend, (v) all
Securities may be sold without any time, volume or manner limitations pursuant to Rule 144(k) or any similar provision then in effect under the Securities Act in the opinion of counsel to the
Company, which counsel shall be reasonably acceptable to the Investor (the "Effectiveness Period"), or (vi) three (3) years from the Effective Date. 


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    (c) All fees, disbursements and out-of-pocket expenses and costs incurred by the Company in connection with the preparation and filing of the
Registration Statement under subparagraph 3(a) and in complying with applicable securities and Blue Sky laws (including, without limitation, all attorneys' fees of the Company) shall be borne by the
Company. The Investors shall bear the cost of underwriting and/or brokerage discounts, fees and commissions, if any, applicable to the Securities being registered and the fees and expenses of their
counsel. The Investors and their counsel shall have a reasonable period, not to exceed five (5) Trading Days, to review the proposed Registration Statement or any amendment thereto, prior to
filing with the Commission, and the Company shall provide each Investor with copies of any comment letters received from the Commission with respect thereto within two (2) Trading Days of
receipt thereof. The Company shall use its best efforts to qualify any of the securities for sale in such states as any Investor reasonably designates and shall furnish indemnification in the manner
provided in Section 6 hereof. However, the Company shall not be required to qualify in any state which will require an escrow or other restriction relating to the Company and/or the sellers, or
which will require the Company to qualify to do business in such state or require the Company to file therein any general consent to service of process. The Company at its expense will supply the
Investors with copies of the applicable Registration Statement and the prospectus included therein and other related documents in such quantities as may be reasonably requested by the Investors. 


    (d) The
Company shall not be required by this Section 3 to include an Investor's Registrable Securities in any Registration Statement which is to be filed if, in
the opinion of counsel for both the Investor and the Company (or, should they not agree, in the opinion of another counsel experienced in securities law matters acceptable to counsel for the Investor
and the Company) the proposed offering or other transfer as to which such registration is requested is exempt from applicable federal and state securities laws and would result in all purchasers or
transferees obtaining securities which are not "restricted securities", as defined in Rule 144 under the Securities Act. 



    (e) In
the event that (i) the Registration Statement to be filed by the Company pursuant to Section 3(a) above is not filed prior to April 15,
2001, (ii) the Registration Statement is not declared effective by the Commission within ninety (90) calendar days (120 calendar days in the event of a "full review" by the Commission)
of the Closing Date, or within five (5) days of clearance by the Commission to request effectiveness, (iii) such Registration Statement is not maintained as effective by the Company for
the period set forth in Section 3(b) above, or (iv) the additional registration statement referred to in Section 3(a) is not filed within 15 calendar days or declared effective
within 60 calendar days as set forth therein (each a "Registration Default") then the Company will pay each Investor (pro-rata on a monthly basis), for each Registration Default then in
effect, as liquidated damages and not as a penalty, during any period in which a Registration Default is occurring, two percent (2%) per month of (i) the then outstanding principal amount of
the Convertible Debentures, and (ii) the value of any outstanding Warrants (valued at the difference between the average closing bid price during the applicable month and the Exercise Price
multiplied by the number of Warrant Shares the Warrants are exercisable into), held by such Investor until such Registration Default no longer exists ("Liquidated
Damages"). Such payment of the Liquidated Damages shall be made to the Investors in cash, or, at the option of the Investor, in shares of Common Stock (based on the Conversion Price (as defined in the
Convertible Debenture)) on the Trading Day prior to the date of payment) on the last day of each month during which a Registration Default occurred or was continuing, without demand therefor by the
Investor; provided, however, that the payment of the Liquidated Damages shall not relieve the Company from its obligations to register the Securities
pursuant to this Section. Notwithstanding anything to the contrary contained herein, a failure to maintain the effectiveness of an filed Registration Statement or the ability of an Investor to use an
otherwise effective Registration Statement to effect resales of Securities during the period after forty-five (45) days and within ninety (90) days from the end of the
Company's fiscal year resulting solely from the need to update the Company's financial statements contained or incorporated by 


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reference in such Registration Statement shall not constitute a Registration Default and shall not trigger the accrual of liquidated damages hereunder. 


    If
the Company does not remit the payment to the Investors as set forth above, the Company will pay the Investors reasonable costs of collection, including attorneys' fees, in
addition to the Liquidated Damages. The registration of the Securities pursuant to this provision shall not affect or limit the Investors' other rights or remedies as set forth in this Agreement. 



    (f)  The
Company shall not be precluded from including in any registration statement which it is required to file pursuant to this Section 3 any other securities
apart from the Registrable Securities. 


    (g) If
at any time or from time to time after the effective date of any Registration Statement, the Company notifies the Investors in writing of the existence of a
Potential Material Event (as defined in Section 3(h) below), the Investors shall not offer or sell any Securities or engage in any other transaction involving or relating to Securities, from
the time of the giving of notice with respect to a Potential Material Event until the Investors receive written notice from the Company that such Potential Material Event either has been disclosed to
the public or no longer constitutes a Potential Material Event; provided, however, that the Company may not so suspend the right to such holders of
Securities for more than twenty (20) calendar days in the aggregate during any twelve month period, during the period the Registration Statement is required to be in effect, and if such period
is exceeded, such event shall be a Registration Default and subject to liquidated damages as set forth in Section 3(e) hereof. If a Potential Material Event shall occur prior to the date a
Registration Statement is required to be filed, then the Company's obligation to file such Registration Statement shall be delayed without penalty for not more than twenty (20) days, and such
delay or delays shall not constitute a Registration Default. Such twenty (20) day period shall not be in addition to the twenty (20) day
period allowed during the period the Registration Statement is required to be in effect. The Company must give the Investors notice in writing prior to the first day of the
blackout period immediately upon knowledge that such a blackout period will occur and such notice must be acknowledged in writing by the
Investors. Failure to provide the Investors with such notice shall constitute a Registration Default during the entire applicable period that the Registration Statement is
suspended. Compliance by the Company with this Section 3(g) will not result in or be deemed a breach of any of the Company's obligations set forth in the Purchase
Agreement not to disclose non-public information to the Investors. 


    (h) "Potential
Material Event" means any of the following: (a) the possession by the Company of material information not ripe for disclosure in a registration
statement, as determined in good faith by the Chief Executive Officer or the Board of Directors of the Company that disclosure of such information in a Registration Statement would be detrimental to
the business and affairs of the Company; or (b) any material engagement or activity by the Company which would, in the good faith determination of the Chief Executive Officer or the Board of
Directors of the Company, be adversely affected by disclosure in a registration statement at such time, which determination shall be accompanied by a good faith determination by the Chief Executive
Officer or the Board of Directors of the Company that the applicable Registration Statement would be materially misleading absent the inclusion of such information. 


    Section 4.  Cooperation with Company.  The Investors will cooperate with the Company in all
respects in connection with this Agreement, including timely supplying all information reasonably requested by the Company (which shall include all information regarding the Investors and proposed
manner of sale of the Registrable Securities required to be disclosed in any Registration Statement) and executing and returning all documents reasonably requested in connection with the registration
and sale of the Registrable Securities and entering into and performing their obligations under any underwriting agreement, if the offering is an underwritten offering, in usual and customary form,
with the managing underwriter or underwriters of such underwritten offering. Nothing in this Agreement 


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shall obligate any Investor to consent to be named as an underwriter in any Registration Statement. The obligation of the Company to register the Registrable Securities shall be absolute and
unconditional as to those Securities which the Commission will permit to be registered without naming the Investors as underwriters. Any delay or delays caused by the Investors by failure to cooperate
as required hereunder shall not constitute a Registration Default. 


    Section 5.  Registration Procedures.  If and whenever the Company is required by any of the
provisions of this Agreement to effect the registration of any of the Registrable Securities under the Act, the Company shall (except as otherwise provided in this Agreement), as expeditiously as
possible, subject to the Investors' assistance and cooperation as reasonably required with respect to each Registration Statement: 



    (a) (i)  prepare
and file with the Commission such amendments and supplements to the Registration Statement and the prospectus used in connection
therewith as may be necessary to keep such Registration Statement effective and to comply with the provisions of the Act with respect to the sale or other disposition of all Registrable Securities
covered by such Registration Statement whenever the Investors shall desire to sell or otherwise dispose of the same (including prospectus supplements with respect to the sales of Registrable
Securities from time to time in connection with a registration statement pursuant to Rule 415 promulgated under the Act) and (ii) take all lawful action such that each of (A) the
Registration Statement and any amendment thereto does not, when it becomes effective, contain an untrue statement of a material fact or omit to state a material fact required to be stated therein or
necessary to make the statements therein, in light of the circumstances under which they were made, not misleading and (B) the prospectus forming part of the Registration Statement, and any
amendment or supplement thereto, does not at any time during the Registration Period include an untrue statement of a material fact or omit to state a material fact required to be stated therein or
necessary to make the statements therein, in light of the circumstances under which they were made, not misleading; 


    (b) (i)  prior
to the filing with the Commission of any Registration Statement (including any amendments thereto) and the distribution or delivery of any
prospectus (including any supplements thereto), provide draft copies thereof to the Investors as required by Section 3(c) and reflect in such documents all such comments as the Investors (and
their counsel) reasonably may propose respecting the Selling Shareholders and Plan of Distribution sections (or equivalents); (ii) furnish to each Investor such numbers of copies of a
prospectus including a preliminary prospectus or any amendment or supplement to any prospectus, as applicable, in conformity with the requirements of the Act, and such other documents, as such
Investor may reasonably request in order to facilitate the public sale or other disposition of the Registrable Securities owned by such Investor; and (iii) provide to each Investor copies of
any comments and communications from the Commission relating to the Registration Statement, if lawful to do so; 


    (c) register
and qualify the Registrable Securities covered by the Registration Statement under such other securities or blue sky laws of such jurisdictions as the
Investors shall reasonably request (subject to the limitations set forth in Section 3(c) above), and do any and all other acts and things which may be necessary or advisable to enable each
Investor to consummate the public sale or other disposition in such jurisdiction of the Registrable Securities owned by such Investor; 


    (d) list
such Registrable Securities on the Principal Market, if the listing of such Registrable Securities is then permitted under the rules of such Principal Market; 


    (e) notify
each Investor at any time when a prospectus relating thereto covered by the Registration Statement is required to be delivered under the Act, of the
happening of any event of which it has knowledge as a result of which the prospectus included in the Registration Statement, as then in effect,
includes an untrue statement of a material fact or omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the 



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light of the circumstances then existing, subject to Section 3(g), and the Company shall prepare and file a curative amendment under Section 5(a) as quickly as commercially
possible and during such period, the Investors shall not make any sales of Registrable Securities pursuant to the Registration Statement; 


    (f)  as
promptly as practicable after becoming aware of such event, notify each Investor who holds Registrable Securities being sold (or, in the event of an
underwritten offering, the managing underwriters) of the issuance by the Commission of any stop order or other suspension of the effectiveness of the Registration Statement at the earliest possible
time and take all lawful action to effect the withdrawal, recession or removal of such stop order or other suspension; 


    (g) cooperate
with the Investors to facilitate the timely preparation and delivery of certificates for the Registrable Securities to be offered pursuant to the
Registration Statement and enable such certificates for the Registrable Securities to be in such denominations or amounts, as the case may be, as the Investors reasonably may request and registered in
such names as the Investors may request; and, within three (3) Trading Days after a Registration Statement which includes Registrable Securities is declared effective by the Commission, deliver
and cause legal counsel selected by the Company to deliver to the transfer agent for the Registrable Securities (with copies to the Investors) an appropriate instruction and, to the extent necessary,
an opinion of such counsel; 


    (h) take
all such other lawful actions reasonably necessary to expedite and facilitate the disposition by the Investors of their Registrable Securities in accordance
with the intended methods therefor provided in the prospectus which are customary for issuers to perform under the circumstances; 


    (i)  in
the event of an underwritten offering, promptly include or incorporate in a prospectus supplement or post-effective amendment to the Registration
Statement such information as the managers reasonably agree should be included therein and to which the Company does not reasonably object and make all required filings of such prospectus supplement
or post-effective amendment as soon as practicable after it is notified of the matters to be included or incorporated in such Prospectus supplement or post-effective amendment;
and 


    (j)  maintain
a transfer agent and registrar for its Common Stock. 




    Section 6.  Indemnification.  


    (a) To
the maximum extent permitted by law, the Company agrees to indemnify and hold harmless the Investors and each person, if any, who controls an Investor within the
meaning of the Securities Act (each a "Distributing Investor") against any losses, claims, damages or liabilities, joint or several (which shall, for all purposes of this Agreement, include, but not
be limited to, all reasonable costs of defense and investigation and all reasonable attorneys' fees and expenses), to which the Distributing Investor may become subject, under the Securities Act or
otherwise, insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon any untrue statement or alleged untrue statement of any material fact
contained in any Registration Statement, or any related final prospectus or amendment or supplement thereto, or arise out of or are based upon the omission or alleged omission to state therein a
material fact required to be stated therein or necessary to make the statements therein not misleading; provided, however, that the Company will not be liable in any such case to the extent, and only
to the extent, that any such loss, claim, damage or liability arises out of or is based upon an untrue statement or alleged untrue statement or omission or alleged omission made in such Registration
Statement, preliminary prospectus, final prospectus or amendment or supplement thereto in reliance upon, and in conformity with, written information furnished to the Company by the Distributing
Investor, its counsel, affiliates or any underwriter, specifically for use in the preparation thereof or (ii) by such Investor's failure to deliver to the 


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purchaser a copy of the most recent prospectus (including any amendments or supplements thereto. This indemnity agreement will be in addition to any liability, which the Company may otherwise have. 



    (b) To
the maximum extent permitted by law, each Distributing Investor agrees that it will indemnify and hold harmless the Company, and each officer and director of the
Company or person, if any, who controls the Company within the meaning of the Securities Act, against any losses, claims, damages or liabilities (which shall, for all purposes of this Agreement,
include, but not be limited to, all reasonable costs of defense and investigation and all reasonable attorneys' fees and expenses) to which the Company or any such officer, director or controlling
person may become subject under the Securities Act or otherwise, insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon any untrue
statement or alleged untrue statement of any material fact contained in any Registration Statement, or any related final prospectus or amendment or supplement thereto, or arise out of or are based
upon the omission or the alleged omission to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading, but in each case only to the extent
that such untrue statement or alleged untrue statement or omission or alleged omission was made in such Registration Statement, final prospectus or amendment or supplement thereto in reliance upon,
and in conformity with, written information furnished to the Company by such Distributing Investor, its counsel, affiliates or any underwriter, specifically for use in the preparation thereof. This
indemnity agreement will be in addition to any liability, which the Distributing Investor may otherwise have. Notwithstanding anything to the contrary herein, the
Distributing Investor shall be liable under this Section 6(b) for only that amount as does not exceed the net proceeds to such Distributing Investor as a result of the sale of Registrable
Securities pursuant to the Registration Statement. 


    (c) Promptly
after receipt by an indemnified party under this Section 6 of notice of the commencement of any action against such indemnified party, such
indemnified party will, if a claim in respect thereof is to be made against the indemnifying party under this Section 6, notify the indemnifying party in writing of the commencement thereof;
but the omission so to notify the indemnifying party will not relieve the indemnifying party from any liability which it may have to any indemnified party except to the extent the failure of the
indemnified party to provide such written notification actually prejudices the ability of the indemnifying party to defend such action. In case any such action is brought against any indemnified
party, and it notifies the indemnifying party of the commencement thereof, the indemnifying party will be entitled to participate in, and, to the extent that it may wish, jointly with any other
indemnifying party similarly notified, assume the defense thereof, subject to the provisions herein stated and after notice from the indemnifying party to such indemnified party of its election so to
assume the defense thereof, the indemnifying party will not be liable to such indemnified party under this Section 6 for any legal or other expenses subsequently incurred by such indemnified
party in connection with the defense thereof other than reasonable costs of investigation, unless the indemnifying party shall not pursue the action to its final conclusion. The indemnified parties as
a group shall have the right to employ one separate counsel in any such action and to participate in the defense thereof, but the fees and expenses of such counsel shall not be at the expense of the
indemnifying party if the indemnifying party has assumed the defense of the action with counsel reasonably satisfactory to the indemnified party unless (i) the employment of such counsel has
been specifically authorized in writing by the indemnifying party, or (ii) the named parties to any such action (including any impleaded parties) include both the indemnified party and the
indemnifying party and the indemnified party shall have been advised by its counsel that there may be one or more legal defenses available to the indemnifying party different from or in conflict with
any legal defenses which may be available to the indemnified party or any other indemnified party (in which case the indemnifying party shall not have the right to assume the defense of such action on
behalf of such indemnified party, it being understood, however, that the indemnifying party shall, in connection with any one such action or separate but substantially similar or related actions in
the same jurisdiction arising out of the same general allegations or circumstances, be liable only for the reasonable fees and 


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expenses of one separate firm of attorneys for the indemnified party, which firm shall be designated in writing by the indemnified party). No settlement of any action against an indemnified party
shall be made without the prior written consent of the indemnified party, which consent shall not be unreasonably withheld so long as such settlement includes a full release of claims against the
indemnified party. 


    All
fees and expenses of the indemnified party (including reasonable costs of defense and investigation in a manner not inconsistent with this Section and all reasonable attorneys'
fees and expenses) shall be paid to the indemnified party, as incurred, within ten (10) Trading Days of written notice thereof to the
indemnifying party; provided, that the indemnifying party may require such indemnified party to undertake to reimburse all such fees and expenses to the extent it is finally judicially determined that
such indemnified party is not entitled to indemnification hereunder. 


    Section 7.  Contribution.  In order to provide for just and equitable contribution under the
Securities Act in any case in which (i) the indemnified party makes a claim for indemnification pursuant to Section 6 hereof but is judicially determined (by the entry of a final
judgment or decree by a court of competent jurisdiction and the expiration of time to appeal or the denial of the last right of appeal) that such indemnification may not be enforced in such case
notwithstanding the fact that the express provisions of Section 6 hereof provide for indemnification in such case, or (ii) contribution under the Securities Act may be required on the
part of any indemnified party, then the Company and the applicable Distributing Investor shall contribute to the aggregate losses, claims, damages or liabilities to which they may be subject (which
shall, for all purposes of this Agreement, include, but not be limited to, all reasonable costs of defense and investigation and all reasonable attorneys' fees and expenses), in either such case
(after contribution from others) on the basis of relative fault as well as any other relevant equitable considerations. The relative fault shall be determined by reference to, among other things,
whether the untrue or alleged untrue statement of a material fact or the omission or alleged omission to state a material fact relates to information supplied by the Company on the one hand or the
applicable Distributing Investor on the other hand, and the parties' relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission. The Company and
the Distributing Investor agree that it would not be just and equitable if contribution pursuant to this Section 7 were determined by pro rata allocation or by any other method of allocation
which does not take account of the equitable considerations referred to in this Section 7. The amount paid or payable by an indemnified party as a result of the losses, claims, damages or
liabilities (or actions in respect thereof) referred to above in this Section 7 shall be deemed to include any legal or other expenses reasonably incurred by such indemnified party in
connection with investigating or defending any such action or claim. No person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) shall be
entitled to contribution from any person who was not guilty of such fraudulent misrepresentation. 


Notwithstanding
any other provision of this Section 7, in no event shall any (i) Investor be required to undertake liability to any person under this Section 7 for any amounts in
excess of the dollar amount of the proceeds received by such Investor from the sale of such Investor's Registrable Securities (after deducting any fees, discounts and commissions applicable thereto)
pursuant to any Registration Statement under which such Registrable Securities are registered under the Securities Act and (ii) underwriter be required to undertake liability to any person
hereunder for any amounts in excess of the aggregate discount, commission or other compensation payable to such underwriter with respect to the Registrable Securities underwritten by it and
distributed pursuant to such Registration Statement. 


    Section 8.  Notices.  All notices, demands, requests, consents, approvals, and other
communications required or permitted hereunder shall be in writing and, unless otherwise specified herein, shall be (i) hand delivered, (ii) deposited in the mail, registered or
certified, return receipt requested, postage
prepaid, (iii) delivered by reputable air courier service with charges prepaid, or (iv) transmitted by facsimile, addressed as set forth in the Purchase Agreement or to such other 


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address as such party shall have specified most recently by written notice. Any notice or other communication required or permitted to be given hereunder shall be deemed effective (a) upon hand
delivery or delivery by facsimile, with accurate confirmation generated by the transmitting facsimile machine, at the address or number designated below (if delivered on a business day during normal
business hours where such notice is to be received), or the first business day following such delivery (if delivered other than on a business day during normal business hours where such notice is to
be received) or (b) on the first business day following the date of sending by reputable courier service, fully prepaid, addressed to such address, or (c) upon actual receipt of such
mailing, if mailed. Either party hereto may from time to time change its address or facsimile number for notices under this Section 8 by giving at least ten (10) days' prior written
notice of such changed address or facsimile number to the other party hereto. 


    Section 9.  Assignment.  This Agreement is binding upon and inures to the benefit of the parties
hereto and their respective heirs, successors and permitted assigns. The rights granted the Investors under this Agreement may be assigned to any purchaser of substantially all of the Registrable
Securities (or the rights thereto) from an Investor, as otherwise permitted by the Purchase Agreement. 


    Section 10.  Additional Covenants of the Company.  The Company agrees that at any time that the
Registration Statement is on Form S-3, for so long as it shall be required to maintain the effectiveness of such registration statement, it shall file all reports and information
required to be filed by it with the Commission in a timely manner and take all such other action so as to maintain such eligibility for the use of such form. 


    Section 11.  Counterparts/Facsimile.  This Agreement may be executed in two or more counterparts,
each of which shall constitute an original, but all of which, when together shall constitute but one and the same instrument, and shall become effective when one or more counterparts have been signed
by each party hereto and delivered to the other parties. In lieu of the original, a facsimile transmission or copy of the original shall be as effective and enforceable as the original. 


    Section 12.  Remedies.  The remedies provided in this Agreement are cumulative and not exclusive
of any remedies provided by law. If any term, provision, covenant or restriction of this Agreement is held by a court of competent jurisdiction to be invalid, illegal, void or unenforceable, the
remainder of the terms, provisions, covenants and restrictions set forth herein shall remain in full force and effect and shall in no way be affected, impaired or invalidated, and the parties hereto
shall use their best efforts to find
and employ an alternative means to achieve the same or substantially the same result as that contemplated by such term, provision, covenant or restriction. 


    Section 13.  Conflicting Agreements.  The Company shall not enter into any agreement with respect
to its securities that is inconsistent with the rights granted to the holders of Registrable Securities in this Agreement or otherwise prevents the Company from complying with all of its obligations
hereunder. 


    Section 14.  Headings.  The headings in this Agreement are for reference purposes only and shall
not affect in any way the meaning or interpretation of this Agreement. 


    Section 15.  Governing Law, Arbitration.  This Agreement shall be governed by and construed in
accordance with the laws of the State of New York applicable to contracts made in New York by persons domiciled in New York City and without regard to its principles of conflicts of laws. Any dispute
under this Agreement shall be submitted to arbitration under the American Arbitration Association (the "AAA") in New York City, New York, and shall be finally and conclusively determined by the
decision of a board of arbitration consisting of three (3) members (hereinafter referred to as the "Board of Arbitration") selected as according to the rules governing the AAA. The Board of
Arbitration shall meet on consecutive business days in New York City, New York, and shall reach and render a decision in writing (concurred in by a majority of the members of the Board of Arbitration) 


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with respect to the amount, if any, which the losing party is required to pay to the other party in respect of a claim filed. In connection with rendering its decisions, the Board of Arbitration shall
adopt and follow the laws of the State of New York. To the extent practical, decisions of the Board of Arbitration shall be rendered no more than thirty (30) calendar days following
commencement of proceedings with respect thereto. The Board of Arbitration shall cause its written decision to be delivered to all parties involved in the dispute. Any decision made by the Board of
Arbitration (either prior to or after the expiration of such thirty (30) calendar day period) shall be final, binding and conclusive on the parties to the dispute, and entitled to be enforced
to the fullest extent permitted by law and entered in any court of competent jurisdiction. The Board of Arbitration shall be authorized and is hereby directed to enter a default judgment against any
party failing to participate in any proceeding hereunder within the time periods set forth in the AAA rules. The non-prevailing party to any arbitration (as determined by the Board of
Arbitration) shall pay the expenses of the prevailing party, including reasonable attorneys' fees, in connection with such arbitration. Any party shall be entitled to obtain injunctive relief from a
court in any case where such relief is available, and the non-prevailing party in any such injunctive proceeding shall pay the expenses of the prevailing party, including reasonable
attorneys' fees, in connection with such injunctive proceeding. 


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    IN WITNESS WHEREOF, the parties hereto have caused this Registration Rights Agreement to be duly executed, on this 22nd day of January, 2001. 



	 	 	CALYPTE BIOMEDICAL CORPORATION
	

 	
 	

By:	
 	

/s/ Nancy Katz
	 	 	 	 	

	 	 	 	 	Nancy Katz, President & CEO
	

 	
 	
INVESTOR:
	

 	
 	

AMRO INTERNATIONAL, S.A.
	

 	
 	

By:	
 	

/s/ H.U. Bachofen
	 	 	 	 	

	 	 	 	 	H.U. Bachofen, Director




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REGISTRATION RIGHTS AGREEMENT