Cyprodinil (PC Code 288202) 

### Dietary Exposure and Ri s k A ss essment DP # 428822 :



### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON

, D

. C

. 20460

O ffi ce of Che mi ca l Safety 

### a n d Po ll ution P r evention



### MEMORANDUM



### March 30

, 2016

SUB J ECT: Cy pr o di n il

- Acute and Chronic Dietary and Drinking Water Ex po s ure and Ri sk

Assessment for the New Use o n T r ee Nut Crop Group 14-12; 

### except almond

, except pistachio.

PC Code: 

### 288202

Dec i s i on No.: 497939

Pet i tio n No.: 4F8333 DP Barcode: 0428822

Reg i st r at i on No. : 

### 100-81 1 

### & 100-13 17

Reg ul atory Ac ti o n: 

### Sect i on 3

Risk Assessmen t Type: Dietary



### TXR No .: NA Case No.: NA

CAS No: 121552-61-2

MRlDNo.: NA

# ~ FROM:

T H ROUG H : 

### Thurston G. Morton, Chem i st

Ri sk Assessme nt Branch I V



### Health Effects Di vision (7509 P )**~**



### Mohsen Sahafeyan, Chemist 

### <-

# //,**.£__.~~~** Seyed Tadayon, C h emist

# ;;:;:,._ / /

Dietary Exposure Science

# ry Counc il (DESAC)

,

and

### ~ 

# 11;2_

E lissa R eaves

, PhD

, Branch Chief

### ~ Health Effects Division ( 750 9P)

TO: 

### Marcel How a rd

Fung i cide Branch

Registration Division 

### (RD) (7505 P )



### Thi s document provides an acute and chronic dietary and drinking water risk analyses of

exposures r esulting from use of cyprodini l as a fungicide on food crops. This assessment

supports requests for the new use on tree nut crop group 14-1 2

, 

### except almond and pistachio.

Page I of22

### Cyprodinil (PC Code 288202) Dietary Exposure and Risk Assessment DP # 428822:



### Executive Summary



### Acut e and chronic di e tary risk assess m e nt s were conducted for cyprodinil using the Dietary

Exposure Eva lu at i o n Model ( D E E M-FC I D

, Version 3. 18 ), w hich incorporates consumption d a ta

from U S DA 's Nationa l H ea lth and N utriti o n Exami n ation Survey, What We Ea t in America,

(NHANES/WWE I A)

. This dietary survey was con du cted from 2003 to 2008

.

Acute Dietan 1 Exposure A nal vs i s R esu lt s and Character iza tion

A co n servat i ve acute dietary exposure analysis was performed for the ge ner a l U

. S. popu l a tion

and v ari o u s pop ul at i on s u bgroups

. To l erance le ve l r es idue s an d 100 % c r op treated assumptions

we r e used. D EEM d efau l t and empi ri cal processi n g fac t o r s we r e used to m odify the to l erance

va lu es

. T h e ac ute ana l ysis incorporat e d th e l in 10 year peak surface drinkin g water estimate

from app licati on of cyprodinil t o grapes. The resulting 95th percentile acute ex p osure estimates

are not of concern for the ge neral U

. S. populat i on or any of the other p op ulation s ubgroup s

. The

s ub group with the highest ri sk est im ate is c hildr en 1-2 years o ld wit h a% acute population

adjusted dose (a P AD) of 8.6%. The% 

## aP A D for the ge neral U.S. popula ti on i s 4.8 %.

C h ro ni c Diet ary Exposu r e Analysis R es ult s and C h aracter i zat ion

A part i a ll y r e fin e d chro ni c diet ary exposure an a l ys i s was performed for the ge neral U.S.

p op ulati o n and var i o u s p o pulati o n subgroups

. For the c hr on i c di e t ary ana l ysis

, tol erance level

residues fo r most commod iti es ; average fie l d tri a l residues for pom e fruit

, he a d lettuce

, l eaf

lettuce

, spi na c h

, t o m ato, and g r apes; and I 00% crop treated assu mpti o n s we r e u sed. D EEM

default and emp iri ca l processing facto r s were used to modi fy the to l e r a n ce values. Th e c hroni c

a n alys i s in corporated th e l 0 yea r average su rfa ce drinking wa ter est imat e from application of

cyprod inil to grapes. Chro ni c dietary risk estimates are ' not of concern fo r the ge n era l U.S.

populati on or any of the o ther populat i on s ubgr oups. The s ub gro up w ith the highest risk est im ate

i s c hildr e n 1-2 years old wit h a% chronic PAD (c PAD ) of 85%. T h e% c P A D fo r the gene ral

U

. S. populati o n i s 29%

.

I. Introduction



### Dietary ri s k assessment in corpo r ates both ex po s ure and to x icity of a g i ve n p est i cide

. For acute

and chronic assessments, the r isk i s exp re sse d as a percentage of a maximum accep tabl e dose

(i.e., th e dose which HED h as co nclud e d w ill result in no unrea sona bl e adverse h ea lth effects).

Th is dose is referred to as the P AD. The PAD i s equiva lent to the po int of departure ( POD

, NOAEL, LOAEL, etc) divided by th e requ ir e d un ce rt ainty o r safety factors.

For ac ut e and non-canc e r chron i c exposu r es, H E D i s co n ce rn ed whe n estimated die t ary ri s k

exceeds l 

### 00% of the P AD. R efe ren ces t h at di scuss the acute and c hroni c risk assessments in

m o r e detail are avai l able o n the E P A/ p es ticid es web s ite: "Av ailable I nformation on Assessing

P age 2 of22Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 3 of 22 Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link:

http://www.epa.gov/fedrgstr/EPA_PEST/2000/July/Day_12/6061.pdf ; or see SOP 99.6

(8/20/99).

The m ost recent dietary risk assessment for cyprodinil was conducted by T. Morton ( 1

- July

- 201 5 ;

DP# 425997 

### ).

II. Residue Information

Residues of Concern

The metabolism of cyprodinil has been studied in apple, peach, potato, tomato, and wheat. The

residue of concern in plants is the parent compound cyprodinil as determined by the HED

Metabolism Assessment Review Committee (MARC) (D243198, G. Kramer, 3/11/98). The

nature of the residue in ruminants is adequately understood based on acceptable lactating goat

m etabolism studies. HED has concluded that the residues of concern for both risk assessment

and the tolerance definition should include the combined residues of cyprodinil and free and

conjugated CGA

- 304075, expressed in parent equivalents (D345970 and D34 5182, G. Kramer,

6/4/08). The water residue s of concern as determined by MARC are the parent and CGA 249287

(4

- cyclopropyl

- 6

- methylpyrimidin

- 2

- amine) (D292557, 6/8/03). HED continues to consider

these metabolites and degradates to be the residues of conc ern.

Table 1 : Summ ary of Residues of Concern for Cyprodini l

Matrix Residues of Concern

For Risk Assessment For Tolerance Expression

Plants cyprodinil cyprodinil

Livestock cyprodinil and CGA

- 304075 cyprodinil and CGA

- 304075

Water cyprodinil and C GA 249287 NA



### Established/Recommended Tolerances

Permanent tolerances are established (40 CFR §180.532(a)) for residues of cyprodinil per se

in/on a variety of crop commodities, at levels ranging from 0.02 ppm in/on almonds to 340 ppm

in citrus oil. Rec ommended tolerances for the proposed new u se are as follows ( D 42 5723

, T

. Morton

, 3 / 30 / 201 6 )

.

Nut, Tree, Group 14

- 12; except almond, except pistachio

........................... 0.04 ppm



### HED continues to recommend that the current tolerance expression for animal commodities be

cha nged to reflect both parent and metabolite CGA

- 304075 ( 4

- [(4

- cyclopropyl

- 6

- methyl

- 2

- 2

- pyrimidinyl)amino]

- phenol ).Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 4 of 22 Residues U sed in the Acute and Chronic Analysis

For the acute dietary analysis, tolerance level residues and 100% crop treated assumptions w ere

used for all treated commodities

. For the chronic dietary analysis, tolerance level residues for

most commodities; average field trial residues for pome fruit, head lettuce, leaf lettuce, spinach,

tomato, and grapes; and 100% crop treated assumptions were used. Default processing factors

were used for most processed commodities , except for tomato paste /puree in the chronic ( 1x ) and

lemon/lime juice (1x) . R esidues used in the acute and chronic dietary analys i s are provided in

Table 2

. Average residue s where noted were used in the chronic dietary analysis.

Table 2. Residue Estimates Used in the Cyprodinil Acute and Chronic Dietary / Drinking Water Analys i s

Commodity Tolerance (ppm)

Crop Subgroup 1B , except sugarbeet 0.75

Crop Group 2 10

Onion

, bulb subgroup 3

- 07A 0.6

Onion, green subgroup 3

- 07B 4.0

Crop Subgroup 4A 5 0 tolerance/0.87 avg head lettuce

50 tolerance/13 avg leaf lettuce

50 tolerance/11.8 avg spinach

Crop Subgroup 4 B 30

Crop Subgroup 5A Head and stem 1.0

Crop Subgroup 5B Leafy Bras sica greens 10

Bean, dry; Bean, succulent 0.6

Vegetable, fruiting, group 8

- 10 1. 5

Crop Group 9 0.7

Lemon, Lime 0.6

Citrus Oil 60

Pome fruit , Crop group 11

- 10 (B. Cropp

- Kohlligian, D378920, 10/27/10) 1.7 tolerance/0.50 avg apple

1.7 tolerance/0.38 av g pear

Stone fruit , Crop group 12 2

Caneberry , s ubgroup 13

- 07A 10

Bushberry s ubgroup 13

- 07 B 3

Small fruit vine climbing subgroup 13

- 07F, except fuzzy kiwifruit (G.

Kramer, D247620, 6/14/02) 3 .0 tolerance/0.81 avg grapes

Low growing berry subgroup 13

- 0 7G, except cranberry 5.0 (inc. strawberry)

Almond 0.02

Pistachio 0.1

Tree Nut Crop Group 14

- 12; except almond, except pistachio 0.04

Crop Subgroup 19A Herb Fresh (except parsley) 3

Crop Subgroup 19A Herb Dried (except parsley) 15

Parsley, dried leaves 170

Parsley leaves 35

Rape seed oil (canola, seed) 0.03

Avocado, Canistel ; Mango ; Papaya ; Sapodilla ; Sapote, black; Sapote,

mamey; Star apple 1.2

Dragonfruit 2.0

Kiwifruit 1.8Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 5 of 22 Table 2. Residue Estimates Used in the Cyprodinil Acute and Chronic Dietary / Drinking Water Analys i s

Commodity Tolerance (ppm)

Watercress 20

Beef, Goat, Ho rse, Sheep, meat byproducts (including liver and kidney ) 0.02

Grape, raisin 5 .0

Turnip, greens 10.0



### The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009,

and 2010. PDP analyze d 1479 catfish samples for cyprodini l residues. There were no detectable

cyprodinil residues. As a result, residues in fish were not included in the assessment.

III. Percent Crop Treated Information

The acute and chronic dietary exposure analyses assumed 100% crop treated (CT).

I V

. Dr inking Water Data

Drinking water residues were incorporated directly into the acute and chronic dietary analys e s as

“water, direct, all sources” and “water, indirect, all sources” and were provided by the

Environmental Fate and Effects Division ( EFED ) ( D 4 25914 , J Melendez 5 / 4 / 1 5 ). The tier 2

aquatic models PRZM (Pesticide Root Zone Model)

- EXAMS (Exposure Analysis Modeling

System) , and the models Screening Concentration in Ground Water ( SCI

- GROW ) and Pesticide

Root Zone Model for Groundwater ( PRZM

- GW ) w ere used to obtain estimated drinking water

concentrations ( EDWCs ) in surface water and groundwater, respectively. The acute EDWC in

surface water is 34.8 μg/L for the total residues of cyprodinil plus CGA

- 249287. The chronic

EDWC in surface waters is 24.7 μg/L for the total residues of cyprodinil and CGA

- 249287. The

cancer/chronic EDWC in surface waters is 16.4 μg/L for the total residues of cyprodinil and

CGA

- 249287. All surface waters EDWCs were obtained using the New York grapes PRZM

scenario. The PRZM

- GW generated EDWC for the use on grapes, using the FL citrus surrogate

scenario were 2.05 μg/L for the total residues of cyprodinil and CGA

- 249287 (acute) and 1.80

μg/L for the total residues (chronic). For details on methods, characterization of results,

uncertainties, etc., please, refer to the previous DWAs. Tab le 3 provides a summary of the Tier 2

modeled drinking water concentrations.

Table 3 . Maximum Estimated Drinking Water Concentrations for the Use of Cyprodinil (expressed as total

residues of cyprodinil plus its degradate CGA

- 249287)

DRINKING WATER SOURC E

(MODEL USED) USE (rate modeled per year ) MAXIMUM ESTIMATED DRINKING WATER

CONCENTRATION (EDWC) ( ppb )

Groundwater ( PRZM

- GW ) FL citrus 1 (1.4 lb a.i.) Acute 2.05

Chronic 1.80

Surface water

(PRZM/ EXAMS) NY grapes (1.4 lb a.i.) Acute 34.8

Chronic 24.7

Cancer/Chronic 16.4

1 Scenario was used as a surrogate and run with the maximum application rate for grapes.Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 6 of 22 V. DEEM

- FCID Program and Consumption Information

Cyprodinil acute and chronic dietary exposure assessments were conducted using the Die tary

Exposure Evaluation Model software with the Food Commodity Intake Database DEEM

- FCID,

Version 3.18 , which incorporates consumption data from USDA’s National Health and Nutrition

Examination Survey, What We Eat in America, (NHANES/WWEIA). This dietary survey was

conducted from 2003 to 20 08 . The data are based on the reported consumption of more than

20,000 individuals over two non

- consecutive survey days. Foods “as consumed” (e.g., apple pie)

are linked to EPA

- defined food commodities (e.g. apples, p eeled fruit

- cooked; fresh or N/S;

baked; or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation

files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption

data are averaged for the entire U.S. population and within population subgroups, but for acute

exposure assessment are retained as individual consumption events. Based on analysis of the

2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the following

population subgroups: the general U.S. population, all infants (<1 year old), children 1

- 2,

children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50

- 99 y ears old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food

form ( e .g. , orange or orange juice) on the food commodity residue list is multiplied by the

average daily consumption estimate for that food/food form . The resulting residue consumption

estimate for each food/food form is summed with the residue consumption estimates for all other

food/food forms on the commodity residue list to arrive at the total average estimated exposure.

Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure

is performed for each population subgroup.

For acute exposure assessments, individual one

- day food consumption data are used on an

individual

- by

- individual basis. The reported consumptio n amounts of each food item can be

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a

deterministic exposure assessment, or “matched” in multiple random pairings with residue values

and then summed in a proba bilistic assessment. The resulting distribution of exposures is

expressed as a percentage of the aPAD on both a user ( i.e. , those who reported eating relevant

commodities/food forms) and a per

- capita ( i.e. , those who reported eating the relevant

commoditi es as well as those who did not) basis. In accordance with HED policy, per capita

exposure and risk are reported for all tiers of analysis. However, for Tiers 1 and 2, significant

differences in user vs. per capita exposure and risk are identified and no ted in the risk

assessment.

VI. Toxicological Information

HED evaluated the toxicology data base for cyprodinil and selected doses and endpoints for chronicCyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 7 of 22 dietary and drinking water risk assessments provided in Table 4

.

Table 4. Summary of Toxicol ogical Doses and Endpoints for Cyprodinil for Use in Dietary Human Health Risk Assessments

Exposure/Scenario Point of

Departure Uncertainty/F

QPA Safety

Factors RfD, PAD, LOC

for Risk

Assessment Study and Toxicological Effects

Acute Dietary

(All Popul ations) NOAEL = 20 0

mg/kg/day UF A = 10x

UF H =10x

FQPA SF= 1x Acute RfD = 2.0

mg/kg/day

aPAD = 2.0

mg/kg/day Acute Neurotoxicity

- Rat

LOAEL = 600 mg/kg/day based on clinical

signs of toxicity, low motor activity and

reversible hypothermia

Chronic Dietary

(All Populations) NOAEL= 2.7

mg/kg/day UF A = 10x

UF H =10x

FQPA SF= 1x Chronic RfD =

0.0 27

mg/kg/day

cPAD =

0.0 27 mg/kg/day 2

- Year Chronic Toxicity/ Carcinogenicity

- rat

LOAEL = 35.6 mg/kg/day based on

degenerative liver lesions (spongiosis hepatis)

in males.

Cancer (all routes) Classification: “Not likely to be carcinogenic to humans”

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of

extrapolati on to determine risk associated with lower environmentally relevant human exposures.

NOAEL = no observed adverse effect level.

LOAEL = lowest observed adverse effect level.

UF = uncertainty factor.

UF A = extrapolation from animal to human (interspe cies).

UF H = potential variation in sensitivity among members of the human population (intraspecies).

FQPA SF = FQPA Safety Factor.

PAD = population adjusted dose (a = acute, c = chronic).

RfD = reference dose.



### VII. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds

100% of the PAD. The DEEM

- FCIDTM analyses estimate the dietary exposure of the U.S.

population and various population subgroups. The results reported in Table s 5 & 6 are for the

general U.S. Population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth

13

- 19, females 13

- 49, adults 20

- 49, and adults 50

- 99 years.Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 8 of 22 Results of Acute Dietary Exposure Analysis

The results of the acute dieta ry exposure analysis are reported in Table 5.

Table 5 : Summary of Acute Dietary Exposure and Risk for Cyprodinil

Population Subgroup a PAD (mg/kg/day) Acute (9 5 th Percentile)

Exposure (mg/kg/day) %aPAD

General U.S. Population

2.0 0.0 9 519 9 4. 8

All Infants (< 1 year old) 0. 101 590 5.1

Children 1

- 2 years old 0. 1726 30 8 .6

Children 3

- 5 years old 0. 158663 7.9

Children 6

- 12 years old 0.0 83374 4. 2

Youth 13

- 19 years old 0.0 71 55 4 3.6

Adults 20

- 49 years old 0.0 9 186 7 4. 6

Adults 50+ years old 0.0 9 1 59 6 4

. 6

Females 13

- 49 years old 0.0 9 670 7 4.8

The bolded % a PAD is the highest.



### Results of Chronic Dietary Exposure Analysis

The results of the chronic dietary exposure analysis are reported in T able 6

.

Table 6 : Summary of Chronic Dietary Exposure and Risk for Cyprodinil

Population Subgroup cPAD (mg/kg/day) Chronic

Exposure (mg/kg/day) % cPAD

General U.S. Population

0.0 27 0.0 0 779 5 2 9

All Infants (< 1 year old) 0.0 1 304 4 4 8

Children 1

- 2 years old 0. 0 2 3 04 7 85

Children 3

- 5 years old 0.0 1 659 4 62

Children 6

- 12 years old 0.0 08 52 4 32

Youth 13

- 19 years old 0.0 0 4 66 6 1 7

Adults 20

- 49 years old 0.0 0 6 32 9 2 3

Adults 50+ years old 0.0 0 7 77 5 2 9

Females 13

- 49 years old 0.0 0 6 70 8 2 5

The bolded %cPAD is the highest.



### VIII. Characterization of Inputs/O utputs

For the acute dietary analysis, tolerance level residues and 100% crop treated assumptions were

used for all treated commodities

. For the chronic dietary analysis, tolerance level residues for

most commodities ; average field trial residues for pom e fruit, head lettuce, leaf lettuce, spinach,

tomatoes, lemon, and grapes; and 100% crop treated assumptions were used. Default processing

factors were used for all processed commodities except tomato paste /puree ( 1 x) and lemon/lime

juice (1x). Risk driv ers are celery, pome fruit, and strawberry. Residues do not warrant further

refinement at this time.Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 9 of 22 IX. Conclusions

An acute and chronic dietary exposure analyses was performed for the general U.S. population

and various population subgroups

. The acut e and chronic risk estimates are below HED’s level

of concern. HED is confid ent the acute and chronic dietary exposures to cyprodinil are not

underestimated.

X. List of Attachments

1. Acute DEEM

- FCID Residue Input File.

2. Results of Acute DEEM

- FCID Dietary Exposure Analysis.

3. Chronic DEEM

- FCID Residue Input File.

4. Results of Chronic DEEM

- FCID Dietary Exposure Analysis.Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 10 of 22 Attachment 1 Acute DEEM

- FCID Residue Input File

Filename: C: \ Users \ tmorton \ Documents \ My Files \ DEEM Files \ 288202 Cyprodinil \ Tr ee Nuts Except

Almond Except Pistachios \ 288202 Acute Food and Water.R08

Chemical: cyprodinil

RfD(Chronic): .03 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 2 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 04

- 09

- 2015/09:44 :19 Program ver. 3.16, 03

- 08

- d

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment

Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101050000 1AB Beet, garden, roots 0.750000 1.000 1.000

0101050001 1AB Beet, garden, roots

- babyfood 0.750000 1.000 1. 000

0101067000 1AB Burdock 0.750000 1.000 1.000

0101078000 1AB Carrot 0.750000 1.000 1.000

0101078001 1AB Carrot

- babyfood 0.750000 1.000 1.000

0101079000 1AB Car rot, juice 0.750000 1.000 1.000

0101084000 1AB Celeriac 0.750000 1.000 1.000

0101100000 1AB Chicory, roots 0.750000 1.000 1.000

0101168000 1AB Ginseng, dried 0.750000 1.000 1.000

0101190000 1AB Horseradish 0.750000 1.000 1.000

0101250000 1AB Parsley, turnip rooted 0.750000 1.000 1.000

0101251000 1AB Parsnip 0.750000 1.000 1.000

0101251001 1AB Parsnip

- babyfood 0.750000 1.000 1.000

0101314000 1AB Radish, roots 0.750000 1.000 1.000

0101316000 1AB Radish, Oriental, roots 0.750000 1.000 1.000

0101327000 1AB R utabaga 0.750000 1.000 1.000

0101331000 1AB Salsify, roots 0.750000 1.000 1.000

0101388000 1AB Turnip, roots 0.750000 1.000 1.000

0200051000 2 Beet, garden, tops 10.000000 1.000 1.000

0200101000 2 Chicory, tops 10.000000 1.000 1.000

0200140000 2 Dasheen, leaves 10.000000 1.000 1.000

0200315000 2 Radish, tops 10.000000 1.000 1.000

0200317000 2 Radish, Oriental, tops 10.000000 1.000 1.000

0200332000 2 Salsify, tops 10.000000 1.000 1.000

0301165000 3A Garlic, bulb 0.600000 1.000 1.000

0301165001 3A Garlic, bulb

- babyfood 0.600000 1.000 1.000

0301237000 3A Onion, bulb 0.600000 1.000 1.000

0301237001 3A Onion, bulb

- babyfood 0.600000 1.000 1.000

0301238000 3A Onion, bulb, dried 0.600000 9.000 1.000

0301238001 3A Onion, bulb, dried

- babyfood 0.600000 9.000 1.000

0301338000 3A Shallot, bulb 0.600000 1.000 1.000

0302103000 3B Chive, fresh leaves 3.000000 1.0 00 1.000

0302198000 3B Leek 4.000000 1.000 1.000

0302239000 3B Onion, green 4.000000 1.000 1.000

0302338500 3B Shallot, fresh leaves 4.000000 1.000 1.000

0401005000 4A Amaranth, leafy 50.000000 1.000 1.000

0401018000 4A Arugula 50.000000 1.000 1.000

0401104000 4A Chrysanthemum, garland 50.000000 1.000 1.000

0401133000 4A Cress, garden 50.000000 1.000 1.000

0401134000 4A Cress, upland 50.000000 1.000 1.000

0401138000 4A Dandelion, leaves 50.000000 1.000 1.000

0401150000 4A Endive 50.000000 1 .000 1.000

0401204000 4A Lettuce, head 50.000000 1.000 1.000

0401205000 4A Lettuce, leaf 50.000000 1.000 1.000

0401248000 4A Parsley, leaves 50.000000 1.000 1.000

0401313000 4A Radicchio 50.000000 1.000 1.000

0401355000 4A Spinach 50.000000 1.000 1.000

0401355001 4A Spinach

- babyfood 50.000000 1.000 1.000

0402076000 4B Cardoon 30.000000 1.000 1.000

0402085000 4B Celery 30.000000 1.000 1.000

0402085001 4B Celery

- babyfood 30.000000 1.000 1.000

0402086000 4B Celery, juice 30.000000 1.000 1.000

0402087000 4B Celtuce 30.000000 1.000 1.000

0402152000 4B Fennel, Florence 30.000000 1.000 1.000

0402322000 4B Rhubarb 30.000000 1.000 1.000

040236700 0 4B Swiss chard 30.000000 1.000 1.000

0501061000 5A Broccoli 1.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 11 of 22 0501061001 5A Broccoli

- babyfood 1.000000 1.000 1.000

0501062000 5A Broccoli, Chinese 1.000000 1.000 1.000

0501064000 5A Brussels sprouts 1.000000 1.000 1.000

0501069000 5A Cabbage 1.000000 1.000 1.000

0501071000 5A Cabbage, Chinese, napa 1.000000 1.000 1.000

0501072000 5A Cabbage, Chinese, mustard 1.000000 1.000 1.000

0501083000 5A Cauliflower 1.000000 1.000 1.000

0501196000 5A Kohlrabi 1.000000 1.000 1.000

0502063 000 5B Broccoli raab 10.000000 1.000 1.000

0502070000 5B Cabbage, Chinese, bok choy 10.000000 1.000 1.000

0502117000 5B Collards 10.000000 1.000 1.000

0502194000 5B Kale 10.000000 1.000 1.000

0502229000 5B Mustard greens 10.000000 1.000 1.000

0502318000 5B Rape greens 10.000000 1.000 1.000

0502389000 5B Turnip, greens 10.0000 00 1.000 1.000

0602031000 6B Bean, broad, succulent 0.600000 1.000 1.000

0602033000 6B Bean, cowpea, succulent 0.600000 1.000 1.000

0602037000 6B Bean, lima, succulent 0.600000 1.000 1.000

06030 30000 6C Bean, black, seed 0.600000 1.000 1.000

0603032000 6C Bean, broad, seed 0.600000 1.000 1.000

0603034000 6C Bean, cowpea, seed 0.600000 1.000 1.000

0603035000 6C Bean, great n orthern, seed 0.600000 1.000 1.000

0603036000 6C Bean, kidney, seed 0.600000 1.000 1.000

0603038000 6C Bean, lima, seed 0.600000 1.000 1.000

0603039000 6C Bean, mung, seed 0.60 0000 1.000 1.000

0603040000 6C Bean, navy, seed 0.600000 1.000 1.000

0603041000 6C Bean, pink, seed 0.600000 1.000 1.000

0603042000 6C Bean, pinto, seed 0.600000 1.000 1.000

060 3098000 6C Chickpea, seed 0.600000 1.000 1.000

0603098001 6C Chickpea, seed

- babyfood 0.600000 1.000 1.000

0603099000 6C Chickpea, flour 0.600000 1.000 1.000

0603182000 6C Guar, seed 0.600000 1.000 1.000

0603182001 6C Guar, seed

- babyfood 0.600000 1.000 1.000

0603203000 6C Lentil, seed 0.600000 1.000 1.000

0801374000 8A Tomatillo 1. 500000 1.000 1.000

0801375000 8A Tomato 1.500000 1.000 1.000

0801375001 8A Tomato

- babyfood 1.500000 1.000 1.000

0801376000 8A Tomato, paste 1.500000 1.000 1.000

0 801376001 8A Tomato, paste

- babyfood 1.500000 1.000 1.000

0801377000 8A Tomato, puree 1.500000 1.000 1.000

0801377001 8A Tomato, puree

- babyfood 1.500000 1.000 1.000

0801378000 8A Tomato, dr ied 1.500000 14.300 1.000

0801378001 8A Tomato, dried

- babyfood 1.500000 14.300 1.000

0801379000 8A Tomato, juice 1.500000 1.000 1.000

0801380000 8A Tomato, Tree 1.500000 1.000 1.000

0802148000 8BC Eggplant 1.500000 1.000 1.000

0802234000 8BC Okra 1.500000 1.000 1.000

0802270000 8B Pepper, bell 1.500000 1.000 1.000

0802270001 8B Pepper, bell

- babyfood 1.500000 1.000 1.000

0802271000 8B Pepper, bell, dried 1.500000 1.000 1.000

0802271001 8B Pepper, bell, dried

- babyfood 1.500000 1.000 1.000

0802272000 8BC Pepper, nonbell 1.500000 1.000 1.000

0802272001 8BC Pepper, nonbell

- babyfood 1.500000 1.000 1.000

0802273000 8BC Pepper, nonbell, dried 1.500000 1.000 1.000

0901075000 9A Cantaloupe 0.700000 1.000 1.000

0901187000 9A Honeydew melon 0.700000 1.000 1.000

0901399000 9A Watermelon 0.700000 1.000 1.000

0901400000 9A Watermelon, juice 0.700000 1.000 1.000

0902021000 9B Balsam pear 0.700000 1.000 1.000

0902088000 9B Chayote, fruit 0.700000 1.000 1.000

0902102000 9B Chinese waxgourd 0.700000 1.000 1.000

0902135000 9B Cucumb er 0.700000 1.000 1.000

0902308000 9B Pumpkin 0.700000 1.000 1.000

0902309000 9B Pumpkin, seed 0.700000 1.000 1.000

0902356000 9B Squash, summer 0.700000 1.000 1.000

0902356001 9B Squash, summer

- babyfood 0.700000 1.000 1.000

0902357000 9B Squash, winter 0.700000 1.000 1.000

0902357001 9B Squash, winter

- babyfood 0.700000 1.000 1.0 00

1001108000 10A Citrus, oil 60.000000 1.000 1.000

1002199000 10B Lemon 0.600000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 12 of 22 1002200000 10B Lemon, juice 0.600000 1.000 1.000

1002200001 10B Lemo n, juice

- babyfood 0.600000 1.000 1.000

1002201000 10B Lemon, peel 0.600000 1.000 1.000

1002206000 10B Lime 0.600000 1.000 1.000

1002207000 10B Lime, juice 0.600000 1.000 1.000

1002207001 10B Lime, juice

- babyfood 0.600000 1.000 1.000

1100007000 11 Apple, fruit with peel 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100008000 11 Apple, peele d fruit 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100008001 11 Apple, peeled fruit

- babyfood 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100009000 11 Apple, dried 1.700000 8.000 1.000 PP#0F7

Full comment: PP#0F7696

1100009001 11 Apple, dried

- babyfood 1.700000 8.000 1.000 PP#0F7

Full comment: PP#0F7696

1100010000 11 Apple, juice 1.700000 1. 300 1.000 PP#0F7

Full comment: PP#0F7696

1100010001 11 Apple, juice

- babyfood 1.700000 1.300 1.000 PP#0F7

Full comment: PP#0F7696

1100011000 11 Apple, sauce 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100011001 11 Apple, sauce

- babyfood 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100129000 11 Crabapple 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100173500 11 Goji berry 1.500000 1.000 1.000

1100210000 11 Loquat 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100266000 11 Pear 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100266001 11 Pear

- babyfood 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100267000 11 Pear, dried 1.700000 6.250 1.000 PP#0F7

Full comment: PP#0F7696

1100268000 11 Pear, juice 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100268001 11 Pear, juice

- babyfood 1.700000 1.000 1.000 P P#0F7

Full comment: PP#0F7696

1100310000 11 Quince 1.700000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1201090000 12A Cherry 2.000000 1.000 1.000

1201090001 12A Ch erry

- babyfood 2.000000 1.000 1.000

1201091000 12A Cherry, juice 2.000000 1.500 1.000

1201091001 12A Cherry, juice

- babyfood 2.000000 1.500 1.000

1202012000 12B Apricot 2.000000 1.000 1.000

1202012001 12B Apricot

- babyfood 2.000000 1.000 1.000

1202013000 12B Apricot, dried 2.000000 6.000 1.000

1202014000 12B Apricot, juice 2.000000 1.000 1.000

1202014001 12B Apricot, juice

- babyfood 2.000000 1.000 1.000

1202230000 12B Nectarine 2.000000 1.000 1.000

1202260000 12B Peach 2.000000 1.000 1.000

1202260001 12B Peach

- babyfood 2.000000 1.000 1.000

1202261000 12B Peach, dried 2.000000 7.000 1.000

1202261001 12B Peach, dried

- babyfood 2.000000 7.000 1.000

1202262000 12B Peach, juice 2.000000 1.000 1.000

1202262001 12B Peach, juice

- babyfood 2.000000 1.000 1.000

1203285000 12C Plum 2.000000 1.000 1.000

1203285001 12C Plum

- babyfood 2.000000 1.00 0 1.000

1203286000 12C Plum, prune, fresh 2.000000 1.000 1.000

1203286001 12C Plum, prune, fresh

- babyfood 2.000000 1.000 1.000

1203287000 12C Plum, prune, dried 2.000000 5.000 1.000

1203287001 12C Plum, prune, dried

- babyfood 2.000000 5.000 1.000

1203288000 12C Plum, prune, juice 2.000000 1.400 1.000

1203288001 12C Plum, prune, juice

- babyfood 2.000000 1.400 1.000

1301055000 13A Blackberry 10.000000 1.000 1.000

1301056000 13A Blackberry, juice 10.000000 1.000 1.000

1301056001 13A Blackberry, juice

- babyfood 10.000000 1.000 1.000

1301058000 13A Boysenberry 10.000000 1. 000 1.000

1301208000 13A Loganberry 10.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 13 of 22 1301320000 13A Raspberry 10.000000 1.000 1.000

1301320001 13A Raspberry

- babyfood 10.000000 1.000 1.000

1301321000 1 3A Raspberry, juice 10.000000 1.000 1.000

1301321001 13A Raspberry, juice

- babyfood 10.000000 1.000 1.000

1302057000 13B Blueberry 3.000000 1.000 1.000

1302057001 13B Blueberry

- babyfood 3.000000 1.000 1.000

1302136000 13B Currant 3.000000 1.000 1.000

1302137000 13B Currant, dried 3.000000 1.000 1.000

1302149000 13B Elderberry 3.000000 1.000 1.000

1302174000 13B Gooseberry 3.000000 1.000 1.000

1302191000 13B Huckleberry 3.000000 1.000 1.000

1304175000 13D Grape 3.000000 1.000 1.000

1304176000 13D Grape, juice 3.000000 1.200 1.000

1304176001 13D Grape, juice

- babyfood 3.000000 1.200 1.000

1304179000 13D Grape, wine and sherry 3.000000 1.000 1.000

1304195000 13D Kiwifruit, fuzzy 1.800000 1.000 1.000

1307359000 13G Strawberry 5.000000 1.000 1.000

1307359001 13G Strawberry

- babyfood 5.000000 1.000 1.000

1307360000 13G Strawberry, juice 5.000000 1.000 1.000

1307360001 13G Strawberry, juice

- babyfood 5.000000 1.000 1.000

1400003000 14 Almond 0.020000 1.000 1.000

1400003001 14 Almond

- babyfood 0.020000 1.000 1.000

14000040 00 14 Almond, oil 0.020000 1.000 1.000

1400004001 14 Almond, oil

- babyfood 0.020000 1.000 1.000

1400059000 14 Brazil nut 0.040000 1.000 1.000

1400068000 14 Butternut 0.040000 1.000 1.000

1400081000 14 Cashew 0.040000 1.000 1.000

1400092000 14 Chestnut 0.040000 1.000 1.000

1400155000 14 Hazelnut 0.04000 0 1.000 1.000

1400156000 14 Hazelnut, oil 0.040000 1.000 1.000

1400185000 14 Hickory nut 0.040000 1.000 1.000

1400213000 14 Macadamia nut 0.040000 1.000 1.000

140026 9000 14 Pecan 0.040000 1.000 1.000

1400278000 14 Pine nut 0.040000 1.000 1.000

1400282000 14 Pistachio 0.100000 1.000 1.000

1400391000 14 Walnut 0.040000 1.000 1.000

1901028000 19A Basil, fresh leaves 3.000000 1.000 1.000

1901028001 19A Basil, fresh leaves

- babyfood 3.000000 1.000 1.000

1901029000 19A Basil, dried leaves 15.000 000 1.000 1.000

1901029001 19A Basil, dried leaves

- babyfood 15.000000 1.000 1.000

1901102500 19A Chive, dried leaves 15.000000 1.000 1.000

1901118000 19A Cilantro, leaves 3.000000 1.000 1.000

1901 118001 19A Cilantro, leaves

- babyfood 3.000000 1.000 1.000

1901144000 19A Dillweed 3.000000 1.000 1.000

1901184000 19A Herbs, other 3.000000 1.000 1.000

1901184001 19A Herbs, other

- babyfood 3.000000 1.000 1.000

1901202000 19A Lemongrass 3.000000 1.000 1.000

1901220000 19A Marjoram 3.000000 1.000 1.000

1901220001 19A Marjoram

- babyfood 3.0 00000 1.000 1.000

1901249000 19A Parsley, dried leaves 170.000000 1.000 1.000

1901249001 19A Parsley, dried leaves

- babyfood 170.000000 1.000 1.000

1901334000 19A Savory 3.000000 1.000 1.000

20 01319000 20A Rapeseed, oil 0.030000 1.000 1.000

2001319001 20A Rapeseed, oil

- babyfood 0.030000 1.000 1.000

3100046000 31 Beef, meat byproducts 0.020000 1.000 1.000

3100046001 31 Beef, meat byproducts

- babyfood 0.020000 1.000 1.000

3100048000 31 Beef, kidney 0.020000 1.000 1.000

3100049000 31 Beef, liver 0.020000 1.000 1.000

3100049001 31 Beef, liver

- babyfood 0 .020000 1.000 1.000

3200170000 32 Goat, meat byproducts 0.020000 1.000 1.000

3200172000 32 Goat, kidney 0.020000 1.000 1.000

3200173000 32 Goat, liver 0.020000 1.000 1.000

3500340000 35 Sheep, meat byproducts 0.020000 1.000 1.000

3500342000 35 Sheep, kidney 0.020000 1.000 1.000

3500343000 35 Sheep, liver 0.020000 1.000 1.000

8601000000 86A Water, di rect, all sources 0.034800 1.000 1.000

8602000000 86B Water, indirect, all sources 0.034800 1.000 1.000

9500001000 O Acerola 1.500000 1.000 1.000

9500016000 O Artichoke, globe 4.000000 1.000 1.000

9500020000 O Avocado 1.200000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 14 of 22 9500074000 O Canistel 1.200000 1.000 1.000

9500151000 O Feijoa 1.500000 1.000 1.000

9500177000 O Grape, leaves 3.000000 1.000 1.000

9500178000 O Grape, raisin 5.000000 1.000 1.000

9500183000 O Guava 1.500000 1.000 1.000

9500183001 O Guava

- b abyfood 1.500000 1.000 1.000

9500209000 O Longan 2.000000 1.000 1.000

9500211000 O Lychee 2.000000 1.000 1.000

9500212000 O Lychee, dried 2.000000 1.850 1.000

9500215000 O Mango 1.200000 1.000 1.000

9500215001 O Mango

- babyfood 1.200000 1.000 1.000

9500216000 O Mango, dried 1.200000 1.000 1.00 0

9500217000 O Mango, juice 1.200000 1.000 1.000

9500217001 O Mango, juice

- babyfood 1.200000 1.000 1.000

9500245000 O Papaya 1.200000 1.000 1.000

9500245001 O Papay a

- babyfood 1.200000 1.000 1.000

9500246000 O Papaya, dried 1.200000 1.800 1.000

9500247000 O Papaya, juice 1.200000 1.500 1.000

9500252000 O Passionfruit 1.500000 1.000 1.000

9500252001 O Passionfruit

- babyfood 1.500000 1.000 1.000

9500253000 O Passionfruit, juice 1.500000 1.000 1.000

9500253001 O Passionfruit, juice

- babyfood 1.500000 1.000 1. 000

9500289000 O Pomegranate 10.000000 1.000 1.000

9500333000 O Sapote, Mamey 1.200000 1.000 1.000

9500351000 O Spanish lime 2.000000 1.000 1.000

9500358000 O Sta rfruit 1.500000 1.000 1.000

9500398000 O Watercress 20.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 15 of 22 Attachment 2 Chronic DEEM

- FCID Residue Input File

Filename: C: \ Users \ tmorton \ Documents \ My Files \ DEEM Files \ 288202 Cyprodinil \ Tree Nuts Except Almond Except

Pistachios \ 288202 Chronic Food and Water.R08

Chemical: cyprodinil

RfD(Chronic): .027 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 1.5 mg/kg bw/day NOEL(Acute): 0 mg /kg bw/day

Date created/last modified: 08

- 24

- 2015/07:49:41 Program ver. 3.16, 03

- 08

- d

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comm ent

Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101050000 1AB Beet, garden, roots 0.750000 1.000 1.000

0101050001 1AB Beet, garden, roots

- babyfood 0.750000 1.000 1.000

0101067000 1AB Burdock 0.750000 1.000 1.000

0101078000 1AB Carrot 0.750000 1.000 1.000

0101078001 1AB Carrot

- babyfood 0.750000 1.000 1.000

0101079000 1AB Carrot, juice 0.750000 1.000 1.000

0101084000 1AB Celeriac 0.750000 1.000 1.000

0101100000 1AB Chicory, roots 0.750000 1.00 0 1.000

0101168000 1AB Ginseng, dried 0.750000 1.000 1.000

0101190000 1AB Horseradish 0.750000 1.000 1.000

0101250000 1AB Parsley, turnip rooted 0.750000 1.000 1.000

0101251000 1AB Parsnip 0.750000 1.000 1.000

0101251001 1AB Parsnip

- babyfood 0.750000 1.000 1.000

0101314000 1AB Radish, roots 0.750000 1.000 1.000

0101316000 1AB Radish, Oriental, roots 0.750000 1.000 1.000

0101327000 1AB Rutabaga 0.750000 1.000 1.000

0101331000 1AB Salsify, roots 0.750000 1.000 1.000

0101388000 1AB Turnip, roots 0.750000 1. 000 1.000

0200051000 2 Beet, garden, tops 10.000000 1.000 1.000

0200101000 2 Chicory, tops 10.000000 1.000 1.000

0200140000 2 Dasheen, leaves 10.000000 1.000 1.000

0200315000 2 Radish, tops 10.000000 1.000 1.000

0200317000 2 Radish, Oriental, tops 10.000000 1.000 1.000

0200332000 2 Salsify, tops 10.000000 1.000 1.000

0301165000 3A Garlic, bulb 0.600000 1.000 1.000

0301165001 3A Garlic, bulb

- babyfood 0.600000 1.000 1.000

0301237000 3A Onion, bulb 0.600000 1.000 1.000

0301237001 3A Onion, bulb

- babyfood 0.600000 1.000 1.000

0301238000 3A Onion, bulb, dried 0.600000 9.000 1.000

0301238001 3A Onion, bulb, dried

- babyfood 0.600000 9.000 1.000

0301338000 3A Shallot, bulb 0.600000 1.000 1.000

0302103000 3B Chive, fresh leaves 3.000000 1.000 1.000

0302198000 3B Leek 4.000000 1.000 1.000

0302239000 3B Onion, green 4.000000 1.000 1.000

0302338500 3B Shallot, fresh leav es 4.000000 1.000 1.000

0401005000 4A Amaranth, leafy 50.000000 1.000 1.000

0401018000 4A Arugula 50.000000 1.000 1.000

0401104000 4A Chrysanthemum, garland 50.000000 1.000 1.000

0401133000 4A Cress, garden 50.000000 1.000 1.000

0401134000 4A Cress, upland 50.000000 1.000 1.000

0401138000 4A Dandelion, leaves 50.000000 1.000 1.000

04011500 00 4A Endive 50.000000 1.000 1.000

0401204000 4A Lettuce, head 0.870000 1.000 1.000

0401205000 4A Lettuce, leaf 13.000000 1.000 1.000

0401248000 4A Parsley, leaves 35.000000 1.000 1.000

0401313000 4A Radicchio 50.000000 1.000 1.000

0401355000 4A Spinach 11.800000 1.000 1.000

0401355001 4A Spinach

- babyfood 11.80000 0 1.000 1.000

0402076000 4B Cardoon 30.000000 1.000 1.000

0402085000 4B Celery 30.000000 1.000 1.000

0402085001 4B Celery

- babyfood 30.000000 1.000 1.000

040208 6000 4B Celery, juice 30.000000 1.000 1.000

0402087000 4B Celtuce 30.000000 1.000 1.000

0402152000 4B Fennel, Florence 30.000000 1.000 1.000

0402322000 4B Rhubarb 30.000000 1.000 1.000

0402367000 4B Swiss chard 30.000000 1.000 1.000

0501061000 5A Broccoli 1.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 16 of 22 0501061001 5A Broccoli

- babyfood 1.000 000 1.000 1.000

0501062000 5A Broccoli, Chinese 1.000000 1.000 1.000

0501064000 5A Brussels sprouts 1.000000 1.000 1.000

0501069000 5A Cabbage 1.000000 1.000 1.000

0501 071000 5A Cabbage, Chinese, napa 1.000000 1.000 1.000

0501072000 5A Cabbage, Chinese, mustard 1.000000 1.000 1.000

0501083000 5A Cauliflower 1.000000 1.000 1.000

0501196000 5A Kohlrabi 1.000000 1.000 1.000

0502063000 5B Broccoli raab 10.000000 1.000 1.000

0502070000 5B Cabbage, Chinese, bok choy 10.000000 1.000 1.000

0502117000 5B Collards 10.0 00000 1.000 1.000

0502194000 5B Kale 10.000000 1.000 1.000

0502229000 5B Mustard greens 10.000000 1.000 1.000

0502318000 5B Rape greens 10.000000 1.000 1.000

05 02389000 5B Turnip, greens 10.000000 1.000 1.000

0602031000 6B Bean, broad, succulent 0.600000 1.000 1.000

0602033000 6B Bean, cowpea, succulent 0.600000 1.000 1.000

0602037000 6B Bean, lima, succulent 0.600000 1.000 1.000

0603030000 6C Bean, black, seed 0.600000 1.000 1.000

0603032000 6C Bean, broad, seed 0.600000 1.000 1.000

0603034000 6C Bean, cowpea, seed 0 .600000 1.000 1.000

0603035000 6C Bean, great northern, seed 0.600000 1.000 1.000

0603036000 6C Bean, kidney, seed 0.600000 1.000 1.000

0603038000 6C Bean, lima, seed 0.600000 1.000 1.000

0603039000 6C Bean, mung, seed 0.600000 1.000 1.000

0603040000 6C Bean, navy, seed 0.600000 1.000 1.000

0603041000 6C Bean, pink, seed 0.600000 1.000 1.000

0603042000 6C Bean, pin to, seed 0.600000 1.000 1.000

0603098000 6C Chickpea, seed 0.600000 1.000 1.000

0603098001 6C Chickpea, seed

- babyfood 0.600000 1.000 1.000

0603099000 6C Chickpea, flour 0.600000 1.000 1.000

0603182000 6C Guar, seed 0.600000 1.000 1.000

0603182001 6C Guar, seed

- babyfood 0.600000 1.000 1.000

0603203000 6C Lentil, seed 0.600000 1.000 1.000

0801374000 8A Tomatillo 0.160000 1.000 1.000

0801375000 8A Tomato 0.160000 1.000 1.000

0801375001 8A Tomato

- babyfood 0.160000 1.000 1.000

0801376000 8A Tomato, paste 0.160000 1.000 1.000

0801376001 8A Tomato, paste

- babyfood 0.160000 1.000 1.000

0801377000 8A Tomato, puree 0.160000 1.000 1.000

0801377001 8A Tomato, puree

- babyfood 0.160000 1.000 1.000

0801378000 8A Tomato, dried 0.160000 14.300 1.000

0801378001 8A Tomato, dried

- babyfood 0.160000 14.300 1.000

0801379000 8A Tomato, juice 0.160000 1.000 1.00 0

0801380000 8A Tomato, Tree 0.160000 1.000 1.000

0802148000 8BC Eggplant 1.500000 1.000 1.000

0802234000 8BC Okra 1.500000 1.000 1.000

0802270000 8B Peppe r, bell 1.500000 1.000 1.000

0802270001 8B Pepper, bell

- babyfood 1.500000 1.000 1.000

0802271000 8B Pepper, bell, dried 1.500000 1.000 1.000

0802271001 8B Pepper, bell, dried

- babyfood 1.500000 1.000 1.000

0802272000 8BC Pepper, nonbell 1.500000 1.000 1.000

0802272001 8BC Pepper, nonbell

- babyfood 1.500000 1.000 1.000

0802273000 8BC Pepper, nonbell, dried 1.500000 1.000 1. 000

0901075000 9A Cantaloupe 0.700000 1.000 1.000

0901187000 9A Honeydew melon 0.700000 1.000 1.000

0901399000 9A Watermelon 0.700000 1.000 1.000

0901400000 9A Wat ermelon, juice 0.700000 1.000 1.000

0902021000 9B Balsam pear 0.700000 1.000 1.000

0902088000 9B Chayote, fruit 0.700000 1.000 1.000

0902102000 9B Chinese waxgourd 0.700000 1.000 1.000

0902135000 9B Cucumber 0.700000 1.000 1.000

0902308000 9B Pumpkin 0.700000 1.000 1.000

0902309000 9B Pumpkin, seed 0.700000 1.000 1.000

0902356000 9B Squash, summer 0.700000 1.000 1.000

0902356001 9B Squash, summer

- babyfood 0.700000 1.000 1.000

0902357000 9B Squash, winter 0.700000 1.000 1.000

0902357001 9B S quash, winter

- babyfood 0.700000 1.000 1.000

1001108000 10A Citrus, oil 60.000000 1.000 1.000

1002199000 10B Lemon 0.260000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 17 of 22 1002200000 10B Lemon, juice 0.260000 1.000 1.000

1002200001 10B Lemon, juice

- babyfood 0.260000 1.000 1.000

1002201000 10B Lemon, peel 0.260000 1.000 1.000

1002206000 10B Lime 0.260000 1.000 1.000

1002207000 10B Lime, juice 0.260000 1.000 1.000

1002207001 10B Lime, juice

- babyfood 0.260000 1.000 1.000

1100007000 11 Apple, fruit with peel 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100008000 11 Apple, peeled fruit 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100008001 11 Apple, peeled fruit

- babyfood 0.500000 1.000 1.000 PP#0F7

Full comment: P P#0F7696

1100009000 11 Apple, dried 0.500000 8.000 1.000 PP#0F7

Full comment: PP#0F7696

1100009001 11 Apple, dried

- babyfood 0.500000 8.000 1.000 PP#0F7

Full comment: PP#0F7696

110001000 0 11 Apple, juice 0.500000 1.300 1.000 PP#0F7

Full comment: PP#0F7696

1100010001 11 Apple, juice

- babyfood 0.500000 1.300 1.000 PP#0F7

Full comment: PP#0F7696

1100011000 11 Apple, sauc e 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100011001 11 Apple, sauce

- babyfood 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100129000 11 Crabapple 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100173500 11 Goji berry 1.500000 1.000 1.000

1100210000 11 Loquat 0.500000 1.000 1.000 PP#0F7

Full comme nt: PP#0F7696

1100266000 11 Pear 0.380000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100266001 11 Pear

- babyfood 0.380000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100 267000 11 Pear, dried 0.380000 6.250 1.000 PP#0F7

Full comment: PP#0F7696

1100268000 11 Pear, juice 0.380000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100268001 11 Pear, juice

- babyfood 0.380000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1100310000 11 Quince 0.500000 1.000 1.000 PP#0F7

Full comment: PP#0F7696

1201090000 12A Cherry 2.000000 1.000 1.000

1201090001 12A Cherry

- babyfood 2.000000 1.000 1.000

1201091000 12A Cherry, juice 2.000000 1.500 1.000

1201091001 12A Cherry, juice

- babyfood 2.000000 1.5 00 1.000

1202012000 12B Apricot 2.000000 1.000 1.000

1202012001 12B Apricot

- babyfood 2.000000 1.000 1.000

1202013000 12B Apricot, dried 2.000000 6.000 1.000

1202014000 12 B Apricot, juice 2.000000 1.000 1.000

1202014001 12B Apricot, juice

- babyfood 2.000000 1.000 1.000

1202230000 12B Nectarine 2.000000 1.000 1.000

1202260000 12B Peach 2.000000 1.000 1.000

1202260001 12B Peach

- babyfood 2.000000 1.000 1.000

1202261000 12B Peach, dried 2.000000 7.000 1.000

1202261001 12B Peach, dried

- babyfood 2.000000 7 .000 1.000

1202262000 12B Peach, juice 2.000000 1.000 1.000

1202262001 12B Peach, juice

- babyfood 2.000000 1.000 1.000

1203285000 12C Plum 2.000000 1.000 1.000

1203285001 12C Plum

- babyfood 2.000000 1.000 1.000

1203286000 12C Plum, prune, fresh 2.000000 1.000 1.000

1203286001 12C Plum, prune, fresh

- babyfood 2.000000 1.000 1.000

1203287000 12C Plum, prune, dried 2.000000 5.000 1.000

1203287001 12C Plum, prune, dried

- babyfood 2.000000 5.000 1.000

1203288000 12C Plum, prune, juice 2.000000 1.400 1.000

1203288001 12C Plum, prune, juice

- babyfood 2.000000 1.400 1.000

1301055000 13A Blackberry 10.000000 1.000 1.000

1301056000 13A Blackberry, juice 10.000000 1.000 1.000

1301056001 13A Blackberry, juice

- babyfood 10.000000 1.000 1.000

130105800 0 13A Boysenberry 10.000000 1.000 1.000

1301208000 13A Loganberry 10.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 18 of 22 1301320000 13A Raspberry 10.000000 1.000 1.000

1301320001 13A Raspberry

- babyfood 10.000000 1.000 1.000

1301321000 13A Raspberry, juice 10.000000 1.000 1.000

1301321001 13A Raspberry, juice

- babyfood 10.000000 1.000 1.000

1302057000 13B Blueberry 3.000000 1.000 1.000

1302057001 13B Blueberry

- babyfood 3.000000 1.000 1.000

1302136000 13B Currant 3.000000 1.000 1.000

1302137000 13B Currant, dried 3.000000 1.000 1.000

1302149 000 13B Elderberry 3.000000 1.000 1.000

1302174000 13B Gooseberry 3.000000 1.000 1.000

1302191000 13B Huckleberry 3.000000 1.000 1.000

1304175000 13D Grape 0.810000 1.000 1.000

1304176000 13D Grape, juice 0.810000 1.200 1.000

1304176001 13D Grape, juice

- babyfood 0.810000 1.200 1.000

1304179000 13D Grape, wine and sherry 0.8100 00 1.000 1.000

1304195000 13D Kiwifruit, fuzzy 1.800000 1.000 1.000

1307359000 13G Strawberry 5.000000 1.000 1.000

1307359001 13G Strawberry

- babyfood 5.000000 1.000 1.000

13073 60000 13G Strawberry, juice 5.000000 1.000 1.000

1307360001 13G Strawberry, juice

- babyfood 5.000000 1.000 1.000

1400003000 14 Almond 0.020000 1.000 1.000

1400003001 14 Almond

- babyfoo d 0.020000 1.000 1.000

1400004000 14 Almond, oil 0.020000 1.000 1.000

1400004001 14 Almond, oil

- babyfood 0.020000 1.000 1.000

1400059000 14 Brazil nut 0.04 0000 1.000 1.000

1400068000 14 Butternut 0.040000 1.000 1.000

1400081000 14 Cashew 0.040000 1.000 1.000

1400092000 14 Chestnut 0.040000 1.000 1.000

140 0155000 14 Hazelnut 0.040000 1.000 1.000

1400156000 14 Hazelnut, oil 0.040000 1.000 1.000

1400185000 14 Hickory nut 0.040000 1.000 1.000

1400213000 14 Macadamia nu t 0.040000 1.000 1.000

1400269000 14 Pecan 0.040000 1.000 1.000

1400278000 14 Pine nut 0.040000 1.000 1.000

1400282000 14 Pistachio 0. 100000 1.000 1.000

1400391000 14 Walnut 0.040000 1.000 1.000

1901028000 19A Basil, fresh leaves 3.000000 1.000 1.000

1901028001 19A Basil, fresh leaves

- babyfood 3.000000 1.000 1.000

1 901029000 19A Basil, dried leaves 15.000000 1.000 1.000

1901029001 19A Basil, dried leaves

- babyfood 15.000000 1.000 1.000

1901102500 19A Chive, dried leaves 15.000000 1.000 1.000

1901118000 19A Cilantro, leaves 3.000000 1.000 1.000

1901118001 19A Cilantro, leaves

- babyfood 3.000000 1.000 1.000

1901144000 19A Dillweed 3.000000 1.000 1.000

1901184000 19A Herbs, other 3.000000 1.000 1.000

1901184001 19A Herbs, other

- babyfood 3.000000 1.000 1.000

1901202000 19A Lemongrass 3.000000 1.000 1.000

1901220000 19A Marjoram 3.000000 1.000 1.000

1901220001 19A Marjoram

- babyfood 3.000000 1.000 1.000

1901249000 19A Parsley, dried leaves 170.000000 1.000 1.000

1901249001 19A Parsley, dried leaves

- babyfood 170.000000 1.000 1.000

1901334000 19A Savory 3.000000 1.000 1.000

2001319000 20A Rapeseed, oil 0.030000 1.000 1.000

2001319001 20A Rapeseed, oil

- babyfood 0.030000 1.000 1.000

3100046000 31 Beef, meat byproducts 0.020000 1.000 1.000

3100046001 31 Beef, meat byproducts

- babyfood 0.020000 1.000 1.000

3100048000 31 Beef, kidney 0.020000 1.000 1.000

3100049000 31 Beef, liver 0.020000 1.000 1.000

3100049001 31 Beef, liver

- babyfood 0.020000 1.000 1.000

3200170000 32 Goat, meat byproducts 0.020000 1.000 1.000

3200172000 32 Goat, kidney 0.020000 1.000 1.000

3200173000 32 Goat, liver 0.020000 1.000 1.000

3500340000 35 Sheep, meat byproducts 0.020000 1.000 1.000

3500342000 35 Sheep, kidney 0.020000 1.000 1.000

3500343000 35 Sheep, liver 0.020000 1.000 1.000

8601000000 86A Water, direct, all sources 0.024700 1.000 1.000

8602000000 86B Water, indirect, all sources 0.024700 1.000 1.000

9500001000 O Acerola 1.500000 1.000 1.0 00

9500016000 O Artichoke, globe 4.000000 1.000 1.000

9500020000 O Avocado 1.200000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 19 of 22 9500074000 O Canistel 1.200000 1.000 1.000

9500151000 O Feij oa 1.500000 1.000 1.000

9500177000 O Grape, leaves 0.810000 1.000 1.000

9500178000 O Grape, raisin 5.000000 1.000 1.000

9500183000 O Guava 1.500000 1.000 1.000

9500183001 O Guava

- babyfood 1.500000 1.000 1.000

9500209000 O Longan 2.000000 1.000 1.000

9500211000 O Lychee 2.000000 1.000 1 .000

9500212000 O Lychee, dried 2.000000 1.850 1.000

9500215000 O Mango 1.200000 1.000 1.000

9500215001 O Mango

- babyfood 1.200000 1.000 1.000

9500216000 O Ma ngo, dried 1.200000 1.000 1.000

9500217000 O Mango, juice 1.200000 1.000 1.000

9500217001 O Mango, juice

- babyfood 1.200000 1.000 1.000

9500245000 O Papaya 1.200000 1.000 1.000

9500245001 O Papaya

- babyfood 1.200000 1.000 1.000

9500246000 O Papaya, dried 1.200000 1.800 1.000

9500247000 O Papaya, juice 1.200000 1.500 1.000

9500252000 O Passionfruit 1.500000 1.000 1.000

9500252001 O Passionfruit

- babyfood 1.500000 1.000 1.000

9500253000 O Passionfruit, juice 1.500000 1.000 1.000

9500253001 O Passionfruit, juice

- babyfood 1.500000 1.000 1.000

9500289000 O Pomegranate 10.000000 1.000 1.000

9500333000 O Sapote, Mamey 1.200000 1.000 1.000

9500351000 O Spanish lime 2.000000 1.000 1.000

9500358000 O Starfruit 1.500000 1.000 1.000

9500398000 O Watercress 20.000000 1.000 1.000Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 20 of 22 Attachment 3 Results of Acute DEEM

- FCID Dietary Exposure Analysis

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for CYPRODINIL NHANES 2003

- 2008 2

- Day

Residue file: 288202 Acute Food and Water.R08 Adjustment fa ctor #2 used.

Analysis Date: 08

- 24

- 2015/07:54:56 Residue file dated: 08

- 24

- 2015/07:52:54

RAC/FF intake summed over 24 hours

Run Comment: ""

===============================================================================

Summary calculations

-- per capita :

95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Total US Popula tion:

0.095199 4.76 0.181586 9.08 0.310240 15.51

All Infants:

0.101590 5.08 0.168266 8.41 0.529162 26.46

Children 1

- 2:

0.172630 8.63 0.277216 13.86 0.443584 22.18

Children 3

- 5:

0.158663 7.93 0.253671 12.68 0.412078 20.60

Children 6

- 12:

0.083374 4.17 0.178318 8.92 0.276164 13.81

Youth 13

- 19:

0.071554 3.58 0.141339 7.07 0.295998 14.80

Adults 20

- 49:

0.091867 4.59 0.182139 9.11 0.314329 15.72

Adults 50

- 99:

0.091596 4.58 0.154314 7.72 0.272421 13.62

Female 13

- 49:

0.096707 4.84 0.187551 9.38 0.327239 16.36



### FOOD ONLY

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis fo r CYPRODINIL NHANES 2003

- 2008 2

- Day

Residue file: 288202 Acute Food Only.R08 Adjustment factor #2 used.

Analysis Date: 08

- 24

- 2015/07:58:22 Residue file dated: 08

- 24

- 2015/07:48:54

RAC/FF intake summed over 24 hours

Run Comme nt: ""

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aR fD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Total US Population:

0.094415 4.72 0.179918 9.00 0.311007 15.55

All Infants:

0.099630 4.9 8 0.167444 8.37 0.528811 26.44

Children 1

- 2:

0.172243 8.61 0.275997 13.80 0.445950 22.30

Children 3

- 5:

0.157736 7.89 0.254674 12.73 0.408833 20.44

Children 6

- 12:

0.082437 4.12 0.177095 8.85 0.274526 13.73

Youth 13

- 19:

0.071136 3.56 0.139979 7.00 0.295954 14.80

Adults 20

- 49:

0.091021 4.55 0.180185 9.01 0.312479 15.62

Adults 50

- 99:

0.090603 4.53 0.153666 7.68 0.270463 13.52

Female 13

- 49:

0.095954 4.80 0.187076 9.35 0.325848 16.29Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 21 of 22 Attachment 4 Results of Chronic DEEM

- FCID Dietary Exposur e Analysis

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for CYPRODINIL NHANES 2003

- 2008 2

- day

Residue file name: C: \ Users \ tmorton \ Documents \ My Files \ DEEM Files \ 288202 Cypro dinil \ Tree Nuts

Except Almond Except Pistachios \ 288202 Chronic Food and Water.R08

Adjustment factor #2 used.

Analysis Date 08

- 24

- 2015/08:28:21 Residue file dated: 08

- 24

- 2015/08:27:06

Reference dose ( RfD, Chronic) = .027 mg/kg bw/day

===============================================================================

Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of

Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.007795 28.9%

Hispanic 0.007304 27.1%

Non

- Hisp

- White 0.008034 29.8%

Non

- Hisp

- Black 0.006326 23.4%

Non

- Hisp

- Other 0.009385 34.8%

Nursing Infants 0.008688 32.2%

Non

- Nursing Infants 0.014990 55.5%

Female 13+ PREG 0.006603 24.5%

Children 1

- 6 0.018326 67.9%

Children 7

- 12 0.007698 28.5%

Male 13

- 19 0.004192 15.5%

Female 13

- 19/NP 0.005154 19.1%

Male 20+ 0.006068 22.5%

Female 20+/NP 0.007733 28.6%

Seniors 55+ 0.007842 29.0%

All Infants 0.013044 48.3%

Female 13

- 50 0.006756 25.0%

Children 1

- 2 0.023047 85.4%

Children 3

- 5 0.016594 61.5%

Children 6

- 12 0.008524 31.6%

Youth 13

- 19 0.004666 17.3%

Adults 20

- 49 0.006329 23.4%

Adults 50

- 99 0.0 07775 28.8%

Female 13

- 49 0.006708 24.8%

-------------------------------------------------------------------------------Cyprodinil (PC C ode 288202 ) Dietary Exposure an d Risk Assessment DP # 42 8822 :



### Page 22 of 22 FOOD ONLY

US EPA Ver. 3.16, 03

- 08

- d

DEEM

- FCID Chronic analysis for CYPRODINIL NHANES 2003

- 2008 2

- day

Residue file name: C: \ Users \ tmorton \ Documents \ My Files \ DEEM Files \ 288202 Cyprodinil \ Tree Nuts

Except Almond Except Pistachios \ 288 202 Chronic Food Only.R08

Adjustment factor #2 used.

Analysis Date 08

- 24

- 2015/08:29:45 Residue file dated: 08

- 24

- 2015/08:27:46

Reference dose (RfD, Chronic) = .027 mg/kg bw/day

====================== =========================================================

Total exposure by population subgroup

-------------------------------------------------------------------------------

Total E xposure

----------------------------------- Population mg/kg Percent of

Subgroup body wt/day Rfd

----------------- --------------------- ------------- ---------------- Total US Population 0.007278 27.0%

Hispanic 0.006810 25.2%

Non

- Hisp

- White 0.0 07502 27.8%

Non

- Hisp

- Black 0.005900 21.9%

Non

- Hisp

- Other 0.008789 32.6%

Nursing Infants 0.008220 30.4%

Non

- Nur sing Infants 0.013270 49.1%

Female 13+ PREG 0.006116 22.7%

Children 1

- 6 0.017664 65.4%

Children 7

- 12 0.007266 26.9%

Male 13

- 19 0.003837 14.2%

Female 13

- 19/NP 0.004756 17.6%

Male 20+ 0.005586 20.7%

F emale 20+/NP 0.007190 26.6%

Seniors 55+ 0.007342 27.2%

All Infants 0.011711 43.4%

Female 13

- 50 0.006241 23.1%

Children 1

- 2 0.022301 82.6%

Children 3

- 5 0.015966 59.1%

Children 6

- 12 0.008070 29.9%

Youth 13

- 19 0.004289 15.9%

Adults 20

- 49 0.005813 21.5%

Adults 50

- 99 0.007264 26.9%

Female 13

- 49 0.006194 22.9%

-------------------------------------------------------------------------------