Mucopolysaccharidoses Fact Sheet

Table of Contents (click to jump to sections)

What are the mucopolysaccharidoses?

Who is at risk?

What are the signs and symptoms?

What are the different types of the mucopolysaccharidoses?

How are the mucopolysaccharidoses diagnosed?

How are the mucopolysaccharidoses treated?

What research is being done?

Where can I get more information?

What are the mucopolysaccharidoses?

The mucopolysaccharidoses are a group of inherited metabolic diseases caused by the absence or malfunctioning of certain enzymes needed to break down 

molecules called glycosaminoglycans - long chains of sugar carbohydrates in each of our cells that help build bone, cartilage, tendons, corneas, skin, and 

connective tissue. Glycosaminoglycans (formerly called mucopolysaccharides) are also found in the fluid that lubricates our joints. 

People with a mucopolysaccharidosis either do not produce enough of one of the 11 enzymes required to break down these sugar chains into proteins and 

simpler molecules or they produce enzymes that do not work properly. Over time, these glycosaminoglycans collect in the cells, blood, and connective tissues. 

The result is permanent, progressive cellular damage that affects the individual's appearance, physical abilities, organ and system functioning, and, in most 

cases, mental development. 

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Who is at risk?

It is estimated that one in every 25,000 babies born in the United States will have some form of the mucopolysaccharidoses. It is an autosomal recessive 

disorder, meaning that only individuals inheriting the defective gene from both parents are affected. (The exception is MPS II, or Hunter syndrome, in which 

the mother alone passes along the defective gene to a son.) When both people in a couple have the defective gene, each pregnancy carries with it a one in 

four chance that the child will be affected. The parents and siblings of an affected child may have no sign of the disorder. Unaffected siblings and select 

relatives of a child with one of the mucopolysaccharidoses may carry the recessive gene and could pass it to their own children. 

In general, the following factors may increase the chance of getting or passing on a genetic disease: 

z A family history of a genetic disease. 

z Parents who are closely related or part of a distinct ethnic or geographic circle. 

z Parents who do not show disease symptoms but carry a disease gene. 

The mucopolysaccharidoses are classified as lysosomal storage diseases. These are conditions in which large numbers of molecules that are normally 

broken down or degraded into smaller pieces by intracellular units called lysosomes accumulate in harmful amounts in the body's cells and tissues, particularly 

in the lysosomes. 

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What are the signs and symptoms?

The mucopolysaccharidoses share many clinical features but have varying degrees of severity. These features may not be apparent at birth but progress as 

storage of glycosaminoglycans affects bone, skeletal structure, connective tissues, and organs. Neurological complications may include damage to neurons 

(which send and receive signals throughout the body) as well as pain and impaired motor function. This results from compression of nerves or nerve roots in 

the spinal cord or in the peripheral nervous system, the part of the nervous system that connects the brain and spinal cord to sensory organs such as the eyes 

and to other organs, muscles, and tissues throughout the body. 

Depending on the mucopolysaccharidoses subtype, affected individuals may have normal intellect or may be profoundly retarded, may experience 

developmental delay, or may have severe behavioral problems. Many individuals have hearing loss, either conductive (in which pressure behind the ear drum 

causes fluid from the lining of the middle ear to build up and eventually congeal), neurosensitive (in which tiny hair cells in the inner ear are damaged), or both. 

Communicating hydrocephalus 3⁄4 in which the normal circulation of cerebrospinal fluid becomes blocked over time and causes increased pressure inside the 

head 3⁄4 is common in some of the mucopolysaccharidoses. Surgically inserting a shunt into the brain can drain fluid. The eye's cornea often becomes cloudy 

from intracellular storage, and degeneration of the retina and glaucoma also may affect the patient's vision. 

Physical symptoms generally include coarse or rough facial features (including a flat nasal bridge, thick lips, and enlarged mouth and tongue), short stature 

with disproportionately short trunk (dwarfism), dysplasia (abnormal bone size and/or shape) and other skeletal irregularities, thickened skin, enlarged organs 

such as liver or spleen, hernias, and excessive body hair growth. Short and often claw-like hands, progressive joint stiffness, and carpal tunnel syndrome can 

restrict hand mobility and function. Recurring respiratory infections are common, as are obstructive airway disease and obstructive sleep apnea. Many 

affected individuals also have heart disease, often involving enlarged or diseased heart valves. 

Another lysosomal storage disease often confused with the mucopolysaccharidoses is mucolipidosis. In this disorder, excessive amounts of fatty materials 

known as lipids (another principal component of living cells) are stored, in addition to sugars. Persons with mucolipidosis may share some of the clinical 

features associated with the mucopolysaccharidoses (certain facial features, bony structure abnormalities, and damage to the brain), and increased amounts 

of the enzymes needed to break down the lipids are found in the blood. 

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What are the different types of the mucopolysaccharidoses?

Sevendistinct clinical types and numerous subtypes of the mucopolysaccharidoses have been identified. Although each mucopolysaccharidosis (MPS) differs 

clinically, most patients generally experience a period of normal development followed by a decline in physical and/or mental function. 

MPS I is divided into three subtypes based on severity of symptoms. All three types result from an absence of, or insufficient levels of, the enzyme alpha-Liduronidase. Children born to an MPS I parent carry the defective gene. 

z MPS I H, Hurler syndrome, is the most severe of the MPS I subtypes. Developmental delay is evident by the end of the first year, and patients 

usually stop developing between ages 2 and 4. This is followed by progressive mental decline and loss of physical skills. Language may be limited 

due to hearing loss and an enlarged tongue. In time, the clear layers of the cornea become clouded and retinas may begin to degenerate. Carpal 

tunnel syndrome (or similar compression of nerves elsewhere in the body) and restricted joint movement are common. 

Affected children may be quite large at birth and appear normal but may have inguinal (in the groin) or umbilical (where the umbilical cord passes through the 

abdomen) hernias. Growth in height may be faster than normal but begins to slow before the end of the first year and often ends around age 3. Many children 

develop a short body trunk and a maximum stature of less than 4 feet. Distinct facial features (including flat face, depressed nasal bridge, and bulging 

forehead) become more evident in the second year. By age 2, the ribs have widened and are oar-shaped. The liver, spleen, and heart are often enlarged. 

Children may experience noisy breathing and recurring upper respiratory tract and ear infections. Feeding may be difficult for some children, and many 

experience periodic bowel problems. Children with Hurler syndrome often die before age 10 from obstructive airway disease, respiratory infections, or cardiac 

complications. 

z MPS I S, Scheie syndrome, is the mildest form of MPS I. Symptoms generally begin to appear after age 5, with diagnosis most commonly made 

after age 10. Children with Scheie syndrome have normal intelligence or may have mild learning disabilities; some may have psychiatric problems. 

Glaucoma, retinal degeneration, and clouded corneas may significantly impair vision. Other problems include carpal tunnel syndrome or other nerve 

compression, stiff joints, claw hands and deformed feet, a short neck, and aortic valve disease. Some affected individuals also have obstructive 

airway disease and sleep apnea. Persons with Scheie syndrome can live into adulthood. 

z MPS I H-S, Hurler-Scheie syndrome, is less severe than Hurler syndrome alone. Symptoms generally begin between ages 3 and 8. Children may 

have moderate mental retardation and learning difficulties. Skeletal and systemic irregularities include short stature, marked smallness in the jaws, 

progressive joint stiffness, compressed spinal cord, clouded corneas, hearing loss, heart disease, coarse facial features, and umbilical hernia. 

Respiratory problems, sleep apnea, and heart disease may develop in adolescence. Some persons with MPS I H-S need continuous positive airway 

pressure during sleep to ease breathing. Life expectancy is generally into the late teens or early twenties. 

Although no studies have been done to determine the frequency of MPS I in the United States, studies in British Columbia estimate that one in 100,000 babies 

born has Hurler syndrome. The estimate for Scheie syndrome is one in 500,000 births and for Hurler-Scheie syndrome it is one in 115,000 births. 

MPS II, Hunter syndrome, is caused by lack of the enzyme iduronate sulfatase. Hunter syndrome has two clinical subtypes and is the only one of the 

mucopolysaccharidoses in which the mother alone can pass the defective gene to a son. The incidence of Hunter syndrome is estimated to be one in every 

100,000 to 150,000 male births. 

z Children with MPS II A, the more severe form of Hunter syndrome, share many of the same clinical features associated with Hurler syndrome (MPS I 

H) but with milder symptoms. Onset of the disease is usually between ages 2 and 4. Developmental decline is usually noticed between the ages of 

18 and 36 months, followed by progressive loss of skills. Other clinical features include coarse facial features, skeletal irregularities, obstructive 

airway and respiratory complications, short stature, joint stiffness, retinal degeneration (but no corneal clouding), communicating hydrocephalus (see 

"What are the signs and symptoms?"), chronic diarrhea, enlarged liver and spleen, and progressive hearing loss. Whitish skin lesions may be found 

on the upper arms, back, and upper legs. Death from upper airway disease or cardiovascular failure usually occurs by age 15. 

z Physical characteristics of MPS II B are less obvious and progress at a much slower rate. Diagnosis is often made in the second decade of life. 

Intellect and social development are not affected. Skeletal problems may be less severe, but carpal tunnel syndrome and joint stiffness can restrict 

movement and height is somewhat less than normal. Other clinical symptoms include hearing loss, poor peripheral vision, diarrhea, and sleep 

apnea, although respiratory and cardiac complications can contribute to premature death. Persons with MPS II B may live into their 50s or beyond. 

MPS III, Sanfilippo syndrome, is marked by severe neurological symptoms. These include progressive dementia, aggressive behavior, hyperactivity, 

seizures, some deafness and loss of vision, and an inability to sleep for more than a few hours at a time. This disorder tends to have three main stages. 

During the first stage, early mental and motor skill development may be somewhat delayed. Affected children show a marked decline in learning between 

ages 2 and 6, followed by eventual loss of language skills and loss of some or all hearing. Some children may never learn to speak. In the syndrome's second 

stage, aggressive behavior, hyperactivity, profound dementia, and irregular sleep may make children difficult to manage, particularly those who retain normal 

physical strength. In the syndrome's last stage, children become increasingly unsteady on their feet and most are unable to walk by age 10. 

Thickened skin and mild changes in facial features, bone, and skeletal structures become noticeable with age. Growth in height usually stops by age 10. Other 

problems may include narrowing of the airway passage in the throat and enlargement of the tonsils and adenoids, making it difficult to eat or swallow. 

Recurring respiratory infections are common. 

There are four distinct types of Sanfilippo syndrome, each caused by alteration of a different enzyme needed to completely break down the heparan sulfate 

sugar chain. Little clinical difference exists between these four types but symptoms appear most severe and seem to progress more quickly in children with 

type A. The average duration of Sanfilippo syndrome is 8 to 10 years following onset of symptoms. Most persons with MPS III live into their teenage years, 

and some live longer. 

z Sanfilippo A is the most severe of the MPS III disorders and is caused by the missing or altered enzyme heparan N-sulfatase. Children with 

Sanfilippo A have the shortest survival rate among those with the MPS III disorders. 

z Sanfilippo B is caused by the missing or deficient enzyme alpha-N-acetylglucosaminidase. 

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z Sanfilippo C results from the missing or altered enzyme acetyl-CoAlpha-glucosaminide acetyltransferase. 

z Sanfilippo D is caused by the missing or deficient enzyme N-acetylglucosamine 6-sulfatase. 

The incidence of Sanfilippo syndrome (for all four types combined) is about one in 70,000 births. 

MPS IV, Morquio syndrome, is estimated to occur in one of every 200,000 births. Its two subtypes result from the missing or deficient enzymes Nacetylgalactosamine 6-sulfatase (Type A) or beta-galactosidase (Type B) needed to break down the keratan sulfate sugar chain. Clinical features are similar 

in both types but appear milder in Morquio Type B. Onset is between ages 1 and 3. Neurological complications include spinal nerve and nerve root 

compression resulting from extreme, progressive skeletal changes, particularly in the ribs and chest; conductive and/or neurosensitive loss of hearing (see 

"What are the signs and symptoms?"); and clouded corneas. Intelligence is normal unless hydrocephalus develops and is not treated. 

Physical growth slows and often stops around age 8. Skeletal abnormalities include a bell-shaped chest, a flattening or curvature of the spine, shortened long 

bones, and dysplasia of the hips, knees, ankles, and wrists. The bones that stabilize the connection between the head and neck can be malformed (odontoid 

hypoplasia); in these cases, a surgical procedure called spinal cervical bone fusion can be lifesaving. Restricted breathing, joint stiffness, and heart disease 

are also common. Children with the more severe form of Morquio syndrome may not live beyond their twenties or thirties. 

Children with MPS VI, Maroteaux-Lamy syndrome, usually have normal intellectual development but share many of the physical symptoms found in Hurler 

syndrome. Caused by the deficient enzyme N-acetylgalactosamine 4-sulfatase, Maroteaux-Lamy syndrome has a variable spectrum of severe symptoms. 

Neurological complications include clouded corneas, deafness, thickening of the dura (the membrane that surrounds and protects the brain and spinal cord), 

and pain caused by compressed or traumatized nerves and nerve roots. 

Growth is normal at first but stops suddenly around age 8. By age 10 children have developed a shortened trunk, crouched stance, and restricted joint 

movement. In more severe cases, children also develop a protruding abdomen and forward-curving spine. Skeletal changes (particularly in the pelvic region) 

are progressive and limit movement. Many children also have umbilical or inguinal hernias. Nearly all children have some form of heart disease, usually 

involving valve dysfunction. 

MPS VII, Sly syndrome, one of the least common forms of the mucopolysaccharidoses, is estimated to occur in fewer than one in 250,000 births. The 

disorder is caused by deficiency of the enzyme beta-glucuronidase. In its rarest form, Sly syndrome causes children to be born with hydrops fetalis, in which 

extreme amounts of fluid are retained in the body. Survival is usually a few months or less. Most children with Sly syndrome are less severely affected. 

Neurological symptoms may include mild to moderate mental retardation by age 3, communicating hydrocephalus, nerve entrapment, corneal clouding, and 

some loss of peripheral and night vision. Other symptoms include short stature, some skeletal irregularities, joint stiffness and restricted movement, and 

umbilical and/or inguinal hernias. Some patients may have repeated bouts of pneumonia during their first years of life. Most children with Sly syndrome live 

into the teenage or young adult years. 

As of 2001, only one case of MPS IX had been reported. The disorder results from hyaluronidase deficiency. Symptoms included nodular soft-tissue masses 

located around joints, with episodes of painful swelling of the masses and pain that ended spontaneously within 3 days. Pelvic radiography showed multiple 

soft-tissue masses and some bone erosion. Other traits included mild facial changes, acquired short stature as seen in other MPS disorders, and normal joint 

movement and intelligence. 

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How are the mucopolysaccharidoses diagnosed?

Diagnosis often can be made through clinical examination and urine tests (excess mucopolysaccharides are excreted in the urine). Enzyme assays (testing a 

variety of cells or body fluids in culture for enzyme deficiency) are also used to provide definitive diagnosis of one of the mucopolysaccharidoses. Prenatal 

diagnosis using amniocentesis and chorionic villus sampling can verify if a fetus either carries a copy of the defective gene or is affected with the disorder. 

Genetic counseling can help parents who have a family history of the mucopolysaccharidoses determine if they are carrying the mutated gene that causes the 

disorders. 

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How are the mucopolysaccharidoses treated?

Currently there is no cure for these disorders. Medical care is directed at treating systemic conditions and improving the person's quality of life. Physical 

therapy and daily exercise may delay joint problems and improve the ability to move. 

Changes to the diet will not prevent disease progression, but limiting milk, sugar, and dairy products has helped some individuals experiencing excessive 

mucus. 

Surgery to remove tonsils and adenoids may improve breathing among affected individuals with obstructive airway disorders and sleep apnea. Sleep studies 

can assess airway status and the possible need for nighttime oxygen. Some patients may require surgical insertion of an endotrachial tube to aid breathing. 

Surgery can also correct hernias, help drain excessive cerebrospinal fluid from the brain, and free nerves and nerve roots compressed by skeletal and other 

abnormalities. Corneal transplants may improve vision among patients with significant corneal clouding. 

Enzyme replacement therapies are currently in use or are being tested. Enzyme replacement therapy has proven useful in reducing non-neurological 

symptoms and pain. 

Bone marrow transplantation (BMT) and umbilical cord blood transplantation (UCBT) have had limited success in treating the mucopolysaccharidoses. 

Abnormal physical characteristics, except for those affecting the skeleton and eyes, may be improved, but neurologic outcomes have varied. BMT and UCBT 

are high-risk procedures and are usually performed only after family members receive extensive evaluation and counseling. 

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What research is being done?

Research funded by the National Institute of Neurological Disorders and Stroke (NINDS) has shown that viral-delivered gene therapy in animal models of the 

mucopolysaccharidoses can stop the buildup of storage materials in brain cells and improve learning and memory. Researchers are planning additional 

studies to understand how gene therapy prompts recovery of mental function in these animal models. It may be years before such treatment is available to 

humans. 

Scientists are working to identify the genes associated with the mucopolysaccharidoses and plan to test new therapies in animal models and in humans. 

Animal models are also being used to investigate therapies that replace the missing or insufficient enzymes needed to break down the sugar chains. 

Gene therapy trials in humans are studying the effects of enzyme replacement on enlarged organs (such as the liver or spleen) and on cardiac and pulmonary 

dysfunction. Additional trials will determine the extent and immediate cause(s) of hearing loss and inner ear dysfunction common to many storage diseases, 

and will identify possible methods to correct structural and functional problems contributing to hearing and balance disturbance. 

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 Where can I get more information?

For more information on neurological disorders or research programs funded by the National Institute of Neurological Disorders and Stroke, contact the 

Institute's Brain Resources and Information Network (BRAIN) at: 

BRAIN 

P.O. Box 5801 

Bethesda, MD 20824 

(800) 352-9424 

www.ninds.nih.gov

Information also is available from the following organizations: 

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"Mucopolysaccharidoses Fact Sheet", NINDS. 

NIH Publication No. 03-5115 

Back to Mucopolysaccharidoses Information Page 

Prepared by: 

Office of Communications and Public Liaison 

National Institute of Neurological Disorders and Stroke 

National Institutes of Health 

Bethesda, MD 20892 

NINDS health-related material is provided for information purposes only and does not necessarily represent endorsement by or an official position of the 

National Institute of Neurological Disorders and Stroke or any other Federal agency. Advice on the treatment or care of an individual patient should be 

National MPS Society, Inc.

P.O. Box 736 

Bangor, ME 04402-0736 

info@mpssociety.org

http://www.mpssociety.org

Tel: 207-947-1445 

Fax: 207-990-3074 

National Organization for Rare Disorders (NORD)

P.O. Box 1968 

(55 Kenosia Avenue) 

Danbury, CT 06813-1968 

orphan@rarediseases.org

http://www.rarediseases.org

Tel: 203-744-0100 Voice Mail 800-999-NORD (6673)

Fax: 203-798-2291 

National Tay-Sachs and Allied Diseases Association

2001 Beacon Street 

Suite 204 

Brighton, MA 02135 

info@ntsad.org

http://www.ntsad.org

Tel: 617-277-4463 800-90-NTSAD (906-8723) 

Fax: 617-277-0134 

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obtained through consultation with a physician who has examined that patient or is familiar with that patient's medical history. 

All NINDS-prepared information is in the public domain and may be freely copied. Credit to the NINDS or the NIH is appreciated. 

Last updated November 04, 2004 

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