Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES

MEMORANDUM 

Date: 23-September-2009

Subject: Spirodiclofen. Dietary Risk Assessment in Support of the Requested use on Avocado, 

Black Sapote, Canistel, Mamey Sapote, Mango, Papaya, Sapodilla, and Star Apple. 

PC Code: 124871 DP Barcode: D367559

Decision No.: 404221 Registration No.: 264-830

Petition No.: 8F7500 Regulatory Action: Section 3 

Risk Assessment Type: single chemical; dietary Case No.: none

TXR No.: not applicable CAS No.: 148477-71-8

MRID Nos: none 40 CFR: 180.608

From/To: Tom Bloem, Chemist

Risk Assessment Branch I/Health Effects Division (RABI/HED; 7509P)

Through: Amelia Acierto, Chemist, RABIII/HED

Mohesen Sahafeyan, Chemist, RABVI/HED

Dietary Exposure Science Advisory Council (DESAC)

George F. Kramer, Ph.D., Senior Chemist

HED/RAB1 (7509P)

Executive Summary

Chronic and cancer dietary risk assessments were conducted using the Dietary Exposure 

Evaluation Model - Food Consumption Intake Database (DEEM-FCID, ver. 2.03) in support of 

Section 3 registration for application of spirodiclofen to avocado, black sapote, canistel, mamey

sapote, mango, papaya, sapodilla, and star apple. Acute dietary risk assessment was not 

conducted since an appropriate endpoint attributable to a single dose was not identified for the 

general U.S. population or any population subgroup. The chronic and cancer analyses assumed 

the following: (1) average field trial residues; (2) experimentally determined processing factors

for apple and grape processed commodities and for citrus oil, peeled citrus, and citrus peel 

(DEEM (ver 7.81) defaults assumed for the remaining processed commodities); (3) BEAD 

projected average percent crop treated estimates for hop (92%), pome fruit (15%), stone fruit 

(10%), grape (7%), and citrus (14%); (4) drinking water estimates derived from the Pesticide Root 

Zone/Exposure Analysis Modeling System (PRZM/EXAMS) model (citrus application scenario; 1 

x 0.31 lb ai/acre) and (5) maximum reasonably balanced livestock diets. The resulting chronic 

risk estimates (food and water) were ≤3.3% cPAD and are not of concern to HED (infants (<1 

year old) were the most highly exposed population). The cancer risk estimate (food and water) for 

the U.S. population was 3 x 10-6. The major contributors to the cancer analysis were hop (40%; 

assumes 100% transfer of residues from hop to beer; spirodiclofen Log KOW = 5.83), water (19%; 

87% of the basin cropped and 100% crop treated), and orange (17%; pending submission of a new 

processing study, default processing factors were assumed). 
Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

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I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to point 

of departure (POD; NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one 

in one million. References which discuss the acute and chronic risk assessments in more detail 

are available on the EPA/pesticides web site: “Available Information on Assessing Exposure 

from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPAPEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (20-AUG-1999). The most recent dietary

risk assessment for spirodiclofen was conducted by Mohsen Sahafeyan (D346757, 3-Jan-2008).

II. Residue Information

Residues of Concern in Plants and Livestock: Table 1 is a summary of the conclusion made by

HED concerning the residues of concern in fruit crops, livestock, and drinking water (Risk 

Assessment Document: D285047, M Clock-Rust et al, 22-Jun-2005; residue chemistry reviews: 

D341847, T. Bloem, 25-Oct-2007 and D359773, T. Bloem, 24-Jun-2009). 

Table 1: Residues of Concern for Tolerance Expression and Risk Assessment.

Matrix Residues included in Risk Assessment Residues included in Tolerance Expression

Citrus fruit, Pome Fruit, Stone Fruit, Tree Nut1spirodiclofen spirodiclofen

Grape1

spirodiclofen spirodiclofen, BAJ 2510

Livestock - Ruminants spirodiclofen, BAJ 2510 spirodiclofen, BAJ 2510

Livestock - Poultry no data submitted

Rotational Crops no data submitted

Drinking Water spirodiclofen, BAJ 2510, BAJ 2740-

dihydroxy, BAJ 2740-ketohydroxy not applicable

1

 Pending the submission of the orange processing data, human-health risk assessments should assume default processing factors 

for all processed commodities excluding the processed commodities for apple and grape (D341847, T. Bloem, 25-Oct-2007). 

Recommended Tolerances: The current petition is for application to avocado, black sapote, 

canistel, mamey sapote, mango, papaya, sapodilla, and star apple (1 x 0.31 lb ai/acre; 2-day

preharvest interval). HED determined that the conclusions concerning the residues of concern in 

the currently registered fruit crops may be extended to the requested crops (see Table 1). Based 

on the review of the residue chemistry data submitted in support of the current petition 

(D363343, T. Bloem, 22-Sep-2009), HED concluded that a 1.0 ppm tolerance for residues of 

spirodiclofen per se in/on the requested crops is appropriate. 

Plant Residues Used in the Chronic/Cancer Risk Assessments: The chronic and cancer dietary

analyses incorporated projected average percent crop treated estimates and average field trial 

residues (see Table 2). Default processing factors were assumed for all commodities excluding 

the processed commodities derived from apple and grape and for citrus oil, peeled citrus, and 

citrus peel where experimentally determined processing factors were incorporated (see Table 2). 

To confirm that the projected percent crop treated estimates remained appropriate, HED requested 

a screening level usage analysis (SLUA) for the registered crops (see Attachment 2). The 

projected percent crop treated estimates are greater than the SLUA for all relevant crops. Since 

the projected percent crop treated estimates are for crops registered in 2007, HED concludes that 

incorporation of the SLUA data into a dietary analysis is not appropriate at this time. 
Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

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Livestock Residues Used in the Chronic/Cancer Risk Assessments: The recommended ruminant 

tolerances were based on maximum theoretical dietary burdens (no poultry/hog feed commodities 

proposed/registered). A more realistic dietary burden (DB) was calculated for ruminants using the 

revised Table 1 feedstuffs. Guidance submitted along with the revised Table 1 indicates that all 

three feed commodities associated with spirodiclofen (dried citrus pulp (beef and dairy), wet apple 

pomace (dairy only), and almond hulls (dairy only)) are considered alternative feedstuffs and only 

one these should be included in livestock dietary burden calculations. Of these three commodities, 

almond hulls and wet apple pomace yields the highest dietary burden estimates for dairy and beef 

cattle, respectively. The guidance associated with revised Table 1 indicates that almond hulls can 

be fed at up to 10% of the dairy cattle diet but 5% is more likely. Since the refined livestock 

residue estimates are for a chronic analysis, HED concluded that almond hulls will be consumed at 

5% of the dairy cattle diet. In addition, the dietary burden calculations for diary cattle were used 

for determination of residues in tissues as diary cattle are ultimately slaughtered for meat. Tables 3 

and 4 are summaries of the dietary burden calculations and ruminant residue estimate, respectively. 

Table 2: Summary of Residue Estimates for the Chronic and Cancer Dietary Exposure Analyses. 

Matrix

Avg Fld Trl Res and 

Projected Ruminant 

Residues (ppm)

% Crop 

Treated 

Estimates1

Processing Factors Crop Translation and/or Comments

pome fruit

apple2- 0.146 15

apple sauce - 0.07x; dried 

apple - 0.18x; peeled apple

- 0.15x; juice - 0.03x

- Apple and pear residues - D285249, T. Bloem, 18-Apr-2005. 

- Apple processing study - D341847, T. Bloem, 25-Oct-2007; 

dried apple and apple juice processing factors translated to dried 

pear and pear juice.

- Per the suggestion of BEAD, the 15% projected average apple 

percent crop treated estimate was translated to all crops in the 

pome fruit crop group.

pear2- 0.239 15 dried pear - 0.18x; pear 

juice - 0.03x

citrus fruit

orange2- 0.104 14

peeled fruit - 0.06x; juice -

1.8x (default); oil - 69x; 

peel - 1.2x

- Orange, lemon, and grapefruit residues - D285249, T. Bloem, 

18-Apr-2005.

- Orange processing study - D285249, T. Bloem, 18-Apr-2005; 

orange peeled fruit and peel processing factors translates to all 

citrus peeled and peel commodities. 

- Per the suggestion of BEAD, the 14% projected average orange 

percent crop treated was translated to all citrus except grapefruit

temple oranges.

lemon2- 0.121 14 juice - 2.0x (default)

grapefruit2- 0.103 13 juice - 2.1x (default)

tree nut almond2

- 0.023 100 --

- Almond and pecan residues -D285249, T. Bloem, 18-Apr-2005.

pecan2-0.019 100 --

stone fruit

peach2- 0.368 10 dried peach - 7.0x (default) - Peach, plum and cherry residues - D285249, T. Bloem, 18-Apr2005.

- per the suggestion of BEAD, the 10% projected average peach 

percent crop treated estimate was translated to all crops in the 

stone fruit crop group.

plum2- 0.068 10 prune dried - 5.0x (default)

prune juice - 1.4x (default)

cherry2- 0.286 10 juice - 1.5x (default)

grape grape - 0.697 7 raisin - 4.3x; juice - 0.17x

- Grape residues - D285249, T. Bloem, 18-Apr-2005; grape 

processing factors - D341847, T. Bloem, 25-Oct-2007.

hop hop - 11.6 92 -- - Hop residues - 47105301.der.doc (14-day PHI).

avocado avocado - 0.110 100 --

- Avocado residue translated to black sapote, canistel, mamey 

sapote, mango, papaya, sapodilla, and star apple based on 

Reviewer’s Guide and Summary of HED ChemSAC Approvals 

for Amending Commodity Definitions [40CFR § 180.1(h)] and 

Crop Group/Subgroups [40 CFR § 180.41] (B. Schneider; 14-

Jun-2002). Default processing factors assumed for papaya. 

cattle, 

goat, 

sheep, 

horse

liver - 0.0009 -- --

- See Tables 3 and 4.

- Residue in kidney translated to meat byproducts (highest of

liver, kidney, and fat).

- Since spirodiclofen may concentrate in milk fat (Kow=5.83), 

residues in milk fat were estimated using the default 25x milk 

fat concentration factor (0.0002 ppm x 25 = 0.005 ppm).

kidney - 0.004 -- --

muscle - 0.0001 -- dried beef - 1.92x (default)

fat - 0.0007 -- --

meat bypdcts - 0.004 -- --

whole milk - 0.0002 -- --

milk fat - 0.005 -- --

1

See attachment 1.

2 Representative crops translated to the remaining crops according to HED SOP 2000.1. 
Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

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Table 3: Calculation of Spirodiclofen Dietary Brudens.

Feed Commodity % Dry Matter1 % Diet1 Average Residue (ppm)2 Dietary Contribution (ppm)3

Beef Cattle

almond hull 90 5 7.20 0.40

MTDB -- 10 -- 0.41

Diary Cattle

almond hull 90 5 7.20 0.40

MTDB -- 10 -- 0.41

1 Revised Table 1 Feedstuffs (June 2008).

2 Average almond hull field trial residue (D285249, T. Bloem, 18-Apr-2005)

3 Dietary contribution = tolerance  % dry matter x % diet.

Table 4: Summary of Cattle Feeding Study and Projected Residue.

Dose; ppm (DBx) Residue (ppm) Projected Residue Assuming a 

Spirodiclofen BAJ 2510 Total 0.41 ppm dietary burden

liver

1.38 (3.4x) not analyzed

4.12 (10.0x) not analyzed

13.75 (33.5x) <0.01 0.01-0.02 <0.02-<0.03 0.0009

kidney

1.38 (3.4x) not analyzed

4.12 (10.0x) <0.01 <0.01-0.03 <0.01-<0.04 0.004

13.75 (33.5x) <0.01 0.04-0.09 <0.05-<0.10 0.003

muscle

1.38 (3.4x) not analyzed

4.12 (10.0x) not analyzed

13.75 (33.5x) <0.002 <0.002 <0.004 0.0001

fat

1.38 (3.4x) not analyzed

4.12 (10.0x) <0.002 <0.002 <0.004 0.0004

13.75 (33.5x) 0.003-0.021 <0.002-0.008 <0.005-0.024 0.0007

whole milk (days 4, 8, 12, 16, 20, 24, 26, and 28)1

1.38 (3.4x) not analyzed

4.12 (10.0x) not analyzed

13.75 (33.5x) <0.001-0.003 <0.001-0.003 <0.002-0.006 0.0002

whey2

1.38 (3.4x) not analyzed

4.12 (10.0x) not analyzed

13.75 (33.5x) <0.001 <0.001-0.001 <0.002 0.00006

cream2

1.38 (3.4x) not analyzed

4.12 (10.0x) not analyzed

13.75 (33.5x) 0.005-0.012 <0.002- 0.002 <0.008- <0.014 0.0004

1

In milk collected from animals dosed at 13.75 ppm, combined residues of spirodiclofen and BAJ 2510 reached a plateau within 

the first week of treatment (0.004 ppm); however, a peak of 0.006 ppm was observed in a single animal on day 20 of dosing. 

2 A milk sample collected from animals dosed at 13.75 ppm with combined residues of 0.004 ppm was processed into whey and 

cream.
Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

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III. Drinking Water Data

Surface and ground estimated drinking water concentrations were previously generated by the 

Environmental Fate and Effects Division (EFED) using PRZM-EXAMS and Screening 

Concentration in Ground Water Model (SCI-GROW), respectively (D311291, F. Kahn, 4-Jan2005). The SCI-GROW model was run using the highest application rate (1 x 0.53 lb ai/acre) and 

resulted in a point estimate of 0.44 ppb. Multiple crop scenarios were modeled using PRZMEXAMS (citrus, pecan, apple, peach, and grape; 87% cropped and 100% crop treated assumed) 

with citrus (1 x 0.31 lb ai/acre) resulting in the highest 1-in-10-year peak concentration (23.86 

ppb), 1-in-10-year yearly average (4.99 ppb), and 30-year average (1.67 ppb). Since the 

applications rates proposed as part of the current petition are identical to the citrus application 

rate, HED concludes that the previously generated water estimates remain relevant. Therefore, the 

chronic and cancer analyses employed the citrus 1-in-10-year yearly average (4.99 ppb) and 30-

year average (1.67 ppb), respectively. 

IV. DEEM-FCID Program and Consumption Information

Spirodiclofen chronic dietary exposure assessments were conducted using the DEEM-FCID

(ver. 2.03), which incorporates consumption data from USDA’s CSFII (1994-1996 and 1998). 

The 1994-96, 98 data are based on the reported consumption of more than 20,000 individuals over 

two non-consecutive survey days. Foods “as consumed” (i.e., apple pie) are linked to EPAdefined food commodities (i.e., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour -

cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by

USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the 

entire U.S. population and within population subgroups, but for acute exposure assessment are 

retained as individual consumption events. Based on analysis of the 1994-96, 98 CSFII 

consumption data, which took into account dietary patterns and survey respondents, HED 

concluded that it is most appropriate to report risk for the following population subgroups: the 

general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 

13-19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (i.e., orange or orange juice) on the food commodity residue list is multiplied by the average 

daily consumption estimate for that food/food form. The resulting residue consumption estimate 

for each food/food form is summed with the residue consumption estimates for all other food/food 

forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is 

expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed 

for each population subgroup.
Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

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IV. Toxicological Information

Table 5 below summarizes the endpoints selected for dietary exposure analyses; for more 

detailed discussion on these endpoints see the HED risk assessment D363343 (in draft). 

Table 5: Summary of Toxicological Doses and Endpoints.

Exposure/

Scenario

Point of 

Departure

Uncertainty/FQPA 

Safety Factors

RfD, PAD, Level 

of Concern Study and Toxicological Effects

Acute Dietary An appropriate endpoint attributable to a single dose was not identified.

Chronic Dietary 

(All 

Populations)

NOAEL= 

1.38 

mg/kg/day

UF = 100

FQPA SF= 1x

cRfD = 0.014 

mg/kg/day

cPAD = 0.014

mg/kg/day

Chronic Oral Toxicity Study in Dogs: LOAEL= 4.7 

mg/kg/day based on increased relative adrenal weights in 

both sexes, increased relative testis weight in males and 

histopathology findings in the adrenal gland of both sexes.

Cancer Classification: “Likely to be Carcinogenic to Humans” with Q1* (mg/kg/day)-1 = 1.49 x 10-2.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and used to 

mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL 

= no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. FQPA SF = FQPA 

Safety Factor. RfD = reference dose. 

V. Results/Discussion

The chronic risk estimates (food and water) were ≤3.3% cPAD and are not of concern to HED 

(infants (<1 year old) were the most highly exposed population). The cancer risk estimate (food 

and water) for the U.S. population was 3 x 10-6. 

Table 6: Summary of Chronic Dietary Exposure and Risk.

Population Subgroup cPAD (mg/kg/day) Exposure (mg/kg/day) %cPAD1

General U.S. Population

0.014

0.000256 1.8

All Infants (< 1 year old) 0.000455 3.3

Children 1-2 years old 0.000432 3.1

Children 3-5 years old 0.000351 2.5

Children 6-12 years old 0.000213 1.5

Youth 13-19 years old 0.000162 1.2

Females 13-49 years old 0.000201 1.4

Adults 20-49 years old 0.000283 2.0

Adults 50+ years old 0.000213 1.5

1

 The bolded %cPAD represents the population with highest risk.

Table 7: Summary of Cancer Dietary Exposure and Risk.

Population Subgroup Q1* Exposure (mg/kg/day) Risk

General U.S. Population 0.0149 0.000186 3 x 10-6
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VI. Characterization of Inputs/Outputs

The chronic and cancer analyses assumed the following: (1) average field trial residues; (2)

experimentally determined processing factors for apple and grape processed commodities and for 

citrus oil, peeled citrus, and citrus peel (DEEM (ver 7.81) defaults assumed for the remaining 

processed commodities); (3) BEAD projected average percent crop treated estimates for hop 

(92%), apple (15%), peach (10%), grape (7%), and orange (14%); (4) drinking water estimates

derived from the PRZM/EXAMS model (citrus application scenario; 1 x 0.31 lb ai/acre); and (5)

maximum reasonably balanced livestock diets. In response to an HED inquiry, BEAD indicated 

that it is appropriate to translate the projected percent crop treated estimates for peach, apple, and 

orange to the remaining crops in the stone fruit, pome fruit, and citrus crop groups, respectively. 

Since the analysis made use of average residues derived from crop field trial studies (maximum 

application rate and minimum preharvest interval), incorporated maximum theoretical processing 

factors for citrus juice, and incorporated surface drinking water estimates which assumed 87% of 

the basin is cropped and 100% of the crops are treated at the maximum rate, HED concludes that 

the exposure estimates provided in this document are unlikely to underestimate actual exposure.

HED is generally concerned when the cancer risk exceeds 10-6. Based on a critical commodity

analysis conducted in DEEM-FCID, the major contributors to the cancer risk were hops (40% 

of the total exposure), water (19% of the total exposure), and orange juice (16% of the total 

exposure). HED notes the following concerning the residue estimates for hop, water, and orange 

juice: (1) hop - DEEM-FCID assumes that 100% of the residue in hops are transferred to beer 

during the brewing process (no residue remain in/on the spent hops); based on the spirodiclofen 

log KOW of 5.83, this is a conservative assumption; in addition, assumed 92% crop treated for 

hops (average projected percent crop treated estimate); (2) water - the water residue estimate 

assumed 87% of the basin is cropped with 100% of the crops treated; and (3) orange juice -

pending the submission of a new orange processing study, default citrus juice processing factors 

are to be assumed (D341847, T. Bloem, 25-Oct-2007); in addition, assumed 14% crop treated for 

orange juice (average projected percent crop treated estimate). Therefore, HED concludes that 

the cancer risk estimate provided in this assessment is conservative and actual cancer risk will be 

significantly lower than 3 x 10-6. 

HED notes that spirodiclofen PDP monitoring data are available for almonds, apple juice, raisin, 

and heavy cream (<LOD residues in/on all samples). Since these commodities contributed only

4% to the total cancer exposure estimate, it was determined that incorporation of these data were 

unnecessary. 
Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

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VII. Conclusions

Aggregate (food + water) chronic and cancer dietary risk analyses for spirodiclofen were 

conducted using DEEM-FCID (ver 2.00) to support the Section 3 registration of spirodiclofen on 

avocado, black sapote, canistel, mamey sapote, mango, papaya, sapodilla, and star apple. The 

chronic and cancer analyses assumed the following: (1) average field trial residues; (2)

experimentally determined processing factors for apple and grape processed commodities and for 

citrus oil, peeled citrus, and citrus peel (DEEM (ver 7.81) defaults assumed for the remaining 

processed commodities); (3) BEAD projected average percent crop treated estimates for hop 

(92%), pome fruit (15%), stone fruit (10%), grape (7%), and citrus (14%); (4) drinking water 

estimates derived from the PRZM/EXAMS model (citrus application scenario; 1 x 0.31 lb 

ai/acre); and (5) maximum reasonably balanced livestock diets. The resulting chronic risk 

estimates (food and water) were ≤3.3% cPAD and are not of concern to HED (infants (<1 year 

old) were the most highly exposed population). The cancer risk estimate (food and water) for the 

U.S. population was 3 x 10-6. The major contributors to the cancer risk were hop (40%), water 

(19%), and orange juice (16%). 

VIII. List of Attachments

Attachment 1: BEAD Projected Percent Crop Treated Estimates.

Attachment 2: BEAD SLUA

Attachment 2: DEEM-FCID Chronic Residue File.

Attachment 3: DEEM-FCID Chronic Exposure Estimates.

Attachment 4: DEEM-FCID Cancer Residue File.

Attachment 5: DEEM-FCID Cancer Exposure Estimates.

Attachment 6: DEEM-FCID Critical Commodity Analysis for Cancer.

cc with all attachments: J. Herbert/Rita Kumar (RD; RM 07; 7505P)

T. Bloem:S10945:Potomac Yard 1:703-605-0217:7509P:RAB1
Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

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Attachment 1: BEAD Projected Percent Crop Treated Estimates; (J. Alsadek, DP # 340691, 

August 2007) 

Crop/New Use Market Leader AVG. PCT/Chronic Max. 

Year ML Avg. PCT/Acute

Hops Abamectin

Abamectin

97

92

99

84 92 99

Oranges, excluding Temples

Abamectin

Abamectin

Abamectin

05

03

01

16

12

14

14 16

Grapes, All

Fenpropathrin/Imidacloprid

Abamectin

Propargite

05

03

01

8

5

9

7 9

Peaches

Hexythiazox

Fenbutatin-oxide

Fenbutatin-oxide

05

03

01

7

11

13

10 13

Apples

Pyridaben

Fenpropathrin/Formetanate 

Pyridaben 

05

03

01

16

12

17

15 17

References: 

National Center for Food & Agricultural Policy (NCFAP), 1992 and 1997

Agricultural Chemical Usage 2001 Fruit Summary, August 2002

Agricultural Chemical Usage 2003 Fruit Summary, August 2004

Agricultural Chemical Usage 2005 Fruit Summary, July 2006

Note: Average %CT of 13% for grapefruit, based on its use in 2005 was recommended by J. 

Alsadek (personal communication, 11/20/07)
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Attachment 2: BEAD SLUA
Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

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Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

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Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

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Attachment 3: DEEM-FCID Chronic Residue File.

Filename: C:\Documents and Settings\tbloem\spirodiclofen\tropical 

fruit\124871chronic.R98

Chemical: spirodiclofen

RfD(Chronic): .014 mg/kg bw/day NOEL(Chronic): 1.38 mg/kg bw/day

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0149

Date created/last modified: 08-04-2009/07:41:30/8 Program ver. 2.03

Comment: no acute endpoint identified; 100x uncertainity factor for chronic

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

95000200 O Avocado 0.110000 1.000 1.000 

95000740 O Canistel 0.110000 1.000 1.000 

95001750 O Grape 0.697000 1.000 0.070 

95001760 O Grape, juice 0.697000 0.170 0.070 

95001761 O Grape, juice-babyfood 0.697000 0.170 0.070 

95001770 O Grape, leaves 0.697000 1.000 0.070 

95001780 O Grape, raisin 0.697000 4.300 0.070 

95001790 O Grape, wine and sherry 0.697000 1.000 0.070 

95001880 O Hop 11.600000 1.000 0.920 

95002150 O Mango 0.110000 1.000 1.000 

95002151 O Mango-babyfood 0.110000 1.000 1.000 

95002160 O Mango, dried 0.110000 1.000 1.000 

95002170 O Mango, juice 0.110000 1.000 1.000 

95002171 O Mango, juice-babyfood 0.110000 1.000 1.000 

95002450 O Papaya 0.110000 1.000 1.000 

95002451 O Papaya-babyfood 0.110000 1.000 1.000 

95002460 O Papaya, dried 0.110000 1.800 1.000 

95002470 O Papaya, juice 0.110000 1.500 1.000 

95003330 O Sapote, Mamey 0.110000 1.000 1.000 

86010000 O Water, direct, all sources 0.004990 1.000 1.000 

86020000 O Water, indirect, all sources 0.004990 1.000 1.000 

21000440 M Beef, meat 0.000100 1.000 1.000 

21000441 M Beef, meat-babyfood 0.000100 1.000 1.000 

21000450 M Beef, meat, dried 0.000100 1.920 1.000 

21000460 M Beef, meat byproducts 0.004000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.004000 1.000 1.000 

21000470 M Beef, fat 0.000700 1.000 1.000 

21000471 M Beef,fat-babyfood 0.000700 1.000 1.000 

21000480 M Beef, kidney 0.004000 1.000 1.000 

21000490 M Beef, liver 0.000900 1.000 1.000 

21000491 M Beef, liver-babyfood 0.000900 1.000 1.000 

23001690 M Goat, meat 0.000100 1.000 1.000 

23001700 M Goat, meat byproducts 0.004000 1.000 1.000 

23001710 M Goat, fat 0.000700 1.000 1.000 

23001720 M Goat, kidney 0.004000 1.000 1.000 

23001730 M Goat, liver 0.000900 1.000 1.000 

24001890 M Horse, meat 0.000100 1.000 1.000 

26003390 M Sheep, meat 0.000100 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.000100 1.000 1.000 

26003400 M Sheep, meat byproducts 0.004000 1.000 1.000 

26003410 M Sheep, fat 0.000700 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.000700 1.000 1.000 

26003420 M Sheep, kidney 0.004000 1.000 1.000 

26003430 M Sheep, liver 0.000900 1.000 1.000 

27002220 D Milk, fat 0.005000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.005000 1.000 1.000 

27012230 D Milk, nonfat solids 0.000200 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.000200 1.000 1.000 

27022240 D Milk, water 0.000200 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.000200 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.000200 1.000 1.000 

10001060 10 Citrus citron 0.104000 1.000 0.140 
Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

Page 14 of 21

10001070 10 Citrus hybrids 0.104000 0.060 0.140 

10001080 10 Citrus, oil 0.121000 69.000 0.140 

10001800 10 Grapefruit 0.103000 0.060 0.130 

10001810 10 Grapefruit, juice 0.103000 2.100 0.130 

10001970 10 Kumquat 0.104000 0.060 0.140 

10001990 10 Lemon 0.121000 0.060 0.140 

10002000 10 Lemon, juice 0.121000 2.000 0.140 

10002001 10 Lemon, juice-babyfood 0.121000 2.000 0.140 

10002010 10 Lemon, peel 0.121000 1.200 0.140 

10002060 10 Lime 0.121000 0.060 0.140 

10002070 10 Lime, juice 0.121000 2.000 0.140 

10002071 10 Lime, juice-babyfood 0.121000 2.000 0.140 

10002400 10 Orange 0.104000 0.060 0.140 

10002410 10 Orange, juice 0.104000 1.800 0.140 

10002411 10 Orange, juice-babyfood 0.104000 1.800 0.140 

10002420 10 Orange, peel 0.104000 1.200 0.140 

10003070 10 Pummelo 0.103000 0.060 0.140 

10003690 10 Tangerine 0.104000 0.060 0.140 

10003700 10 Tangerine, juice 0.104000 2.300 0.140 

11000070 11 Apple, fruit with peel 0.146000 1.000 0.150 

11000080 11 Apple, peeled fruit 0.146000 0.150 0.150 

11000081 11 Apple, peeled fruit-babyfood 0.146000 0.150 0.150 

11000090 11 Apple, dried 0.146000 0.180 0.150 

11000091 11 Apple, dried-babyfood 0.146000 0.180 0.150 

11000100 11 Apple, juice 0.146000 0.030 0.150 

11000101 11 Apple, juice-babyfood 0.146000 0.030 0.150 

11000110 11 Apple, sauce 0.146000 0.070 0.150 

11000111 11 Apple, sauce-babyfood 0.146000 0.070 0.150 

11001290 11 Crabapple 0.146000 1.000 0.150 

11002100 11 Loquat 0.239000 1.000 0.150 

11002660 11 Pear 0.239000 1.000 0.150 

11002661 11 Pear-babyfood 0.239000 1.000 0.150 

11002670 11 Pear, dried 0.239000 0.180 0.150 

11002680 11 Pear, juice 0.239000 0.030 0.150 

11002681 11 Pear, juice-babyfood 0.239000 0.030 0.150 

11003100 11 Quince 0.239000 1.000 0.150 

12000120 12 Apricot 0.368000 1.000 0.100 

12000121 12 Apricot-babyfood 0.368000 1.000 0.100 

12000130 12 Apricot, dried 0.368000 6.000 0.100 

12000140 12 Apricot, juice 0.368000 1.000 0.100 

12000141 12 Apricot, juice-babyfood 0.368000 1.000 0.100 

12000900 12 Cherry 0.286000 1.000 0.100 

12000901 12 Cherry-babyfood 0.286000 1.000 0.100 

12000910 12 Cherry, juice 0.286000 1.500 0.100 

12000911 12 Cherry, juice-babyfood 0.286000 1.500 0.100 

12002300 12 Nectarine 0.368000 1.000 0.100 

12002600 12 Peach 0.368000 1.000 0.100 

12002601 12 Peach-babyfood 0.368000 1.000 0.100 

12002610 12 Peach, dried 0.368000 7.000 0.100 

12002611 12 Peach, dried-babyfood 0.368000 7.000 0.100 

12002620 12 Peach, juice 0.368000 1.000 0.100 

12002621 12 Peach, juice-babyfood 0.368000 1.000 0.100 

12002850 12 Plum 0.068000 1.000 0.100 

12002851 12 Plum-babyfood 0.068000 1.000 0.100 

12002860 12 Plum, prune, fresh 0.068000 1.000 0.100 

12002861 12 Plum, prune, fresh-babyfood 0.068000 1.000 0.100 

12002870 12 Plum, prune, dried 0.068000 5.000 0.100 

12002871 12 Plum, prune, dried-babyfood 0.068000 5.000 0.100 

12002880 12 Plum, prune, juice 0.068000 1.400 0.100 

12002881 12 Plum, prune, juice-babyfood 0.068000 1.400 0.100 

14000030 14 Almond 0.023000 1.000 1.000 

14000031 14 Almond-babyfood 0.023000 1.000 1.000 

14000040 14 Almond, oil 0.023000 1.000 1.000 

14000041 14 Almond, oil-babyfood 0.023000 1.000 1.000 

14000590 14 Brazil nut 0.019000 1.000 1.000 

14000680 14 Butternut 0.019000 1.000 1.000 
Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

Page 15 of 21

14000810 14 Cashew 0.019000 1.000 1.000 

14000920 14 Chestnut 0.023000 1.000 1.000 

14001550 14 Filbert 0.019000 1.000 1.000 

14001560 14 Filbert, oil 0.019000 1.000 1.000 

14001850 14 Hickory nut 0.019000 1.000 1.000 

14002130 14 Macadamia nut 0.019000 1.000 1.000 

14002690 14 Pecan 0.019000 1.000 1.000 

14002820 14 Pistachio 0.023000 1.000 1.000 

14003910 14 Walnut 0.019000 1.000 1.000 
Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

Page 16 of 21

Attachment 4: DEEM-FCID Chronic Exposure Estimates.

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for SPIRODICLOFEN (1994-98 data)

Residue file name: C:\Documents and Settings\tbloem\spirodiclofen\tropical 

fruit\124871chronic.R98

 Adjustment factor #2 used.

Analysis Date 08-04-2009/07:44:23 Residue file dated: 08-04-2009/07:41:30/8

Reference dose (RfD, Chronic) = .014 mg/kg bw/day

COMMENT 1: no acute endpoint identified; 100x uncertainity factor for chronic

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------

U.S. Population (total) 0.000256 1.8%

U.S. Population (spring season) 0.000271 1.9%

U.S. Population (summer season) 0.000275 2.0%

U.S. Population (autumn season) 0.000239 1.7%

U.S. Population (winter season) 0.000241 1.7%

Northeast region 0.000249 1.8%

Midwest region 0.000263 1.9%

Southern region 0.000231 1.6%

Western region 0.000297 2.1%

Hispanics 0.000273 1.9%

Non-hispanic whites 0.000260 1.9%

Non-hispanic blacks 0.000219 1.6%

Non-hisp/non-white/non-black 0.000271 1.9%

All infants (< 1 year) 0.000455 3.3%

Nursing infants 0.000192 1.4%

Non-nursing infants 0.000555 4.0%

Children 1-6 yrs 0.000366 2.6%

Children 7-12 yrs 0.000200 1.4%

Females 13-19 (not preg or nursing) 0.000141 1.0%

Females 20+ (not preg or nursing) 0.000205 1.5%

Females 13-50 yrs 0.000215 1.5%

Females 13+ (preg/not nursing) 0.000198 1.4%

Females 13+ (nursing) 0.000230 1.6%

Males 13-19 yrs 0.000181 1.3%

Males 20+ yrs 0.000315 2.3%

Seniors 55+ 0.000205 1.5%

Children 1-2 yrs 0.000432 3.1%

Children 3-5 yrs 0.000351 2.5%

Children 6-12 yrs 0.000213 1.5%

Youth 13-19 yrs 0.000162 1.2%

Adults 20-49 yrs 0.000283 2.0%

Adults 50+ yrs 0.000213 1.5%

Females 13-49 yrs 0.000201 1.4%

-------------------------------------------------------------------------------
Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

Page 17 of 21

Attachment 5: DEEM-FCID Cancer Residue File.

Filename: C:\Documents and Settings\tbloem\spirodiclofen\tropical 

fruit\124871cancer.R98

Chemical: spirodiclofen

RfD(Chronic): .014 mg/kg bw/day NOEL(Chronic): 1.38 mg/kg bw/day

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0149

Date created/last modified: 08-04-2009/07:42:18/8 Program ver. 2.03

Comment: no acute endpoint identified; 100x uncertainity factor for chronic

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

95000200 O Avocado 0.110000 1.000 1.000 

95000740 O Canistel 0.110000 1.000 1.000 

95001750 O Grape 0.697000 1.000 0.070 

95001760 O Grape, juice 0.697000 0.170 0.070 

95001761 O Grape, juice-babyfood 0.697000 0.170 0.070 

95001770 O Grape, leaves 0.697000 1.000 0.070 

95001780 O Grape, raisin 0.697000 4.300 0.070 

95001790 O Grape, wine and sherry 0.697000 1.000 0.070 

95001880 O Hop 11.600000 1.000 0.920 

95002150 O Mango 0.110000 1.000 1.000 

95002151 O Mango-babyfood 0.110000 1.000 1.000 

95002160 O Mango, dried 0.110000 1.000 1.000 

95002170 O Mango, juice 0.110000 1.000 1.000 

95002171 O Mango, juice-babyfood 0.110000 1.000 1.000 

95002450 O Papaya 0.110000 1.000 1.000 

95002451 O Papaya-babyfood 0.110000 1.000 1.000 

95002460 O Papaya, dried 0.110000 1.800 1.000 

95002470 O Papaya, juice 0.110000 1.500 1.000 

95003330 O Sapote, Mamey 0.110000 1.000 1.000 

86010000 O Water, direct, all sources 0.001670 1.000 1.000 

86020000 O Water, indirect, all sources 0.001670 1.000 1.000 

21000440 M Beef, meat 0.000100 1.000 1.000 

21000441 M Beef, meat-babyfood 0.000100 1.000 1.000 

21000450 M Beef, meat, dried 0.000100 1.920 1.000 

21000460 M Beef, meat byproducts 0.004000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.004000 1.000 1.000 

21000470 M Beef, fat 0.000700 1.000 1.000 

21000471 M Beef,fat-babyfood 0.000700 1.000 1.000 

21000480 M Beef, kidney 0.004000 1.000 1.000 

21000490 M Beef, liver 0.000900 1.000 1.000 

21000491 M Beef, liver-babyfood 0.000900 1.000 1.000 

23001690 M Goat, meat 0.000100 1.000 1.000 

23001700 M Goat, meat byproducts 0.004000 1.000 1.000 

23001710 M Goat, fat 0.000700 1.000 1.000 

23001720 M Goat, kidney 0.004000 1.000 1.000 

23001730 M Goat, liver 0.000900 1.000 1.000 

24001890 M Horse, meat 0.000100 1.000 1.000 

26003390 M Sheep, meat 0.000100 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.000100 1.000 1.000 

26003400 M Sheep, meat byproducts 0.004000 1.000 1.000 

26003410 M Sheep, fat 0.000700 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.000700 1.000 1.000 

26003420 M Sheep, kidney 0.004000 1.000 1.000 

26003430 M Sheep, liver 0.000900 1.000 1.000 

27002220 D Milk, fat 0.005000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.005000 1.000 1.000 

27012230 D Milk, nonfat solids 0.000200 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.000200 1.000 1.000 

27022240 D Milk, water 0.000200 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.000200 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.000200 1.000 1.000 

10001060 10 Citrus citron 0.104000 1.000 0.140 
Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

Page 18 of 21

10001070 10 Citrus hybrids 0.104000 0.060 0.140 

10001080 10 Citrus, oil 0.121000 69.000 0.140 

10001800 10 Grapefruit 0.103000 0.060 0.130 

10001810 10 Grapefruit, juice 0.103000 2.100 0.130 

10001970 10 Kumquat 0.104000 0.060 0.140 

10001990 10 Lemon 0.121000 0.060 0.140 

10002000 10 Lemon, juice 0.121000 2.000 0.140 

10002001 10 Lemon, juice-babyfood 0.121000 2.000 0.140 

10002010 10 Lemon, peel 0.121000 1.200 0.140 

10002060 10 Lime 0.121000 0.060 0.140 

10002070 10 Lime, juice 0.121000 2.000 0.140 

10002071 10 Lime, juice-babyfood 0.121000 2.000 0.140 

10002400 10 Orange 0.104000 0.060 0.140 

10002410 10 Orange, juice 0.104000 1.800 0.140 

10002411 10 Orange, juice-babyfood 0.104000 1.800 0.140 

10002420 10 Orange, peel 0.104000 1.200 0.140 

10003070 10 Pummelo 0.103000 0.060 0.140 

10003690 10 Tangerine 0.104000 0.060 0.140 

10003700 10 Tangerine, juice 0.104000 2.300 0.140 

11000070 11 Apple, fruit with peel 0.146000 1.000 0.150 

11000080 11 Apple, peeled fruit 0.146000 0.150 0.150 

11000081 11 Apple, peeled fruit-babyfood 0.146000 0.150 0.150 

11000090 11 Apple, dried 0.146000 0.180 0.150 

11000091 11 Apple, dried-babyfood 0.146000 0.180 0.150 

11000100 11 Apple, juice 0.146000 0.030 0.150 

11000101 11 Apple, juice-babyfood 0.146000 0.030 0.150 

11000110 11 Apple, sauce 0.146000 0.070 0.150 

11000111 11 Apple, sauce-babyfood 0.146000 0.070 0.150 

11001290 11 Crabapple 0.146000 1.000 0.150 

11002100 11 Loquat 0.239000 1.000 0.150 

11002660 11 Pear 0.239000 1.000 0.150 

11002661 11 Pear-babyfood 0.239000 1.000 0.150 

11002670 11 Pear, dried 0.239000 0.180 0.150 

11002680 11 Pear, juice 0.239000 0.030 0.150 

11002681 11 Pear, juice-babyfood 0.239000 0.030 0.150 

11003100 11 Quince 0.239000 1.000 0.150 

12000120 12 Apricot 0.368000 1.000 0.100 

12000121 12 Apricot-babyfood 0.368000 1.000 0.100 

12000130 12 Apricot, dried 0.368000 6.000 0.100 

12000140 12 Apricot, juice 0.368000 1.000 0.100 

12000141 12 Apricot, juice-babyfood 0.368000 1.000 0.100 

12000900 12 Cherry 0.286000 1.000 0.100 

12000901 12 Cherry-babyfood 0.286000 1.000 0.100 

12000910 12 Cherry, juice 0.286000 1.500 0.100 

12000911 12 Cherry, juice-babyfood 0.286000 1.500 0.100 

12002300 12 Nectarine 0.368000 1.000 0.100 

12002600 12 Peach 0.368000 1.000 0.100 

12002601 12 Peach-babyfood 0.368000 1.000 0.100 

12002610 12 Peach, dried 0.368000 7.000 0.100 

12002611 12 Peach, dried-babyfood 0.368000 7.000 0.100 

12002620 12 Peach, juice 0.368000 1.000 0.100 

12002621 12 Peach, juice-babyfood 0.368000 1.000 0.100 

12002850 12 Plum 0.068000 1.000 0.100 

12002851 12 Plum-babyfood 0.068000 1.000 0.100 

12002860 12 Plum, prune, fresh 0.068000 1.000 0.100 

12002861 12 Plum, prune, fresh-babyfood 0.068000 1.000 0.100 

12002870 12 Plum, prune, dried 0.068000 5.000 0.100 

12002871 12 Plum, prune, dried-babyfood 0.068000 5.000 0.100 

12002880 12 Plum, prune, juice 0.068000 1.400 0.100 

12002881 12 Plum, prune, juice-babyfood 0.068000 1.400 0.100 

14000030 14 Almond 0.023000 1.000 1.000 

14000031 14 Almond-babyfood 0.023000 1.000 1.000 

14000040 14 Almond, oil 0.023000 1.000 1.000 

14000041 14 Almond, oil-babyfood 0.023000 1.000 1.000 

14000590 14 Brazil nut 0.019000 1.000 1.000 

14000680 14 Butternut 0.019000 1.000 1.000 
Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

Page 19 of 21

14000810 14 Cashew 0.019000 1.000 1.000 

14000920 14 Chestnut 0.023000 1.000 1.000 

14001550 14 Filbert 0.019000 1.000 1.000 

14001560 14 Filbert, oil 0.019000 1.000 1.000 

14001850 14 Hickory nut 0.019000 1.000 1.000 

14002130 14 Macadamia nut 0.019000 1.000 1.000 

14002690 14 Pecan 0.019000 1.000 1.000 

14002820 14 Pistachio 0.023000 1.000 1.000 

14003910 14 Walnut 0.019000 1.000 1.000 
Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

Page 20 of 21

Attachment 6: DEEM-FCID Cancer Exposure Estimates.

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for SPIRODICLOFEN (1994-98 data)

Residue file name: C:\Documents and Settings\tbloem\spirodiclofen\tropical 

fruit\124871cancer.R98

 Adjustment factor #2 used.

Analysis Date 08-04-2009/07:44:45 Residue file dated: 08-04-2009/07:42:18/8

Q* = 0.0149 

COMMENT 1: no acute endpoint identified; 100x uncertainity factor for chronic

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Lifetime risk

 Subgroup body wt/day (Q*= .0149)

-------------------------------------- ------------- -------------

U.S. Population (total) 0.000186 2.78E-06

-------------------------------------------------------------------------------
Spirodiclofen Dietary Exposure and Risk Assessment DP Number: D367559

Page 21 of 21

Attachment 7: DEEM-FCID Critical Commodity Analysis for Cancer.

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for SPIRODICLOFEN (1994-98 data)

Residue file name: C:\Documents and Settings\tbloem\spirodiclofen\tropical 

fruit\124871cancer.R98

 Adjustment factor #2 used.

Analysis Date 08-04-2009/07:45:03 Residue file dated: 08-04-2009/07:42:18/8

Q* = 0.0149 

COMMENT 1: no acute endpoint identified; 100x uncertainity factor for chronic

===============================================================================

 Critical Commodity Contribution Analysis for

 U.S. Population (total)

 Total Exposure =.0001864 mg/kg bw/day

 Crop groups with total exposure contribution > 5%

 Foods/Foodforms with exposure contribution > 5%

-------------------------------------------------------------------------------

Crop group -----------Exposure analysis----------

 Food mg/kg | % of Total| Lifetime Risk

 Foodform body wt/day| Exposure |(Q*= .0149)

-------------------------------------- -----------|-----------|--------------

Crop Group = (O) Other

 Hop (95001880):

 FoodForm N/S 0.0000746 40.05% 1.11E-06

 Water, direct, all sources (86010000):

 FoodForm N/S 0.0000203 10.87% 3.02E-07

 Water, indirect, all sources (86020000):

 FoodForm N/S 0.0000149 8.01% 2.23E-07

-------------------------------------- -----------|-----------|--------------

 Total for crop group 0.0001319 70.77% 1.97E-06

Crop Group = (10) Citrus Fruits

 Orange, juice (10002410):

 FoodForm N/S 0.0000307 16.45% 4.57E-07

-------------------------------------- -----------|-----------|--------------

 Total for crop group 0.0000341 18.27% 5.07E-07

Crop Group = (11) Pome Fruits

 Total for crop group 0.0000106 5.67% 1.57E-07

Total for crop groups listed above: 0.0001765 94.71% 2.63E-06

-------------------------------------------------------------------------------