Exhibit 10.5



 Exhibit 10.5 

EMPLOYMENT AGREEMENT 

This Employment Agreement (“Agreement”) is made and entered into effective as of January 13, 2015 (“Effective
Date”) by and between CoLucid Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and Thomas P. Mathers (“Executive”). 

Recitals 
 A. The
Company desires to employ or continue to employ Executive, and Executive desires to be employed or to continue to be employed by the Company. 

B. The Company and Executive desire to enter into an agreement embodying the terms of such employment. 

Agreement 
 NOW,
THEREFORE, in consideration of the foregoing and the mutual promises set forth in this Agreement, and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Company and Executive agree as follows:

 1. Effective Date. This Agreement shall be effective as of the Effective Date. 

2. Term. Subject to earlier termination as provided in Section 7 of this Agreement, the original term of this Agreement shall be
for a period beginning on the Effective Date and ending on the fourth anniversary of the Effective Date (“Initial Term”); provided, however, that commencing with fourth anniversary of the Effective Date and each anniversary thereof,
this Agreement shall be automatically extended for successive terms of one (1) year each unless either party provides written notice not to so extend to the other party at least sixty (60) calendar days before the end of the then current
term, in which case no further automatic extension shall occur (the duration of Executive’s employment, including the Initial Term plus any extended terms or such shorter period if terminated as provided in Section 7, is hereinafter
referred to as the “Term”). 
 3. Position and Responsibilities. During the Term, the Company hereby employs the
Executive, and the Executive hereby accepts employment with the Company, to serve as President and Chief Executive Officer. In such capacity, the Executive shall have such duties, authorities and responsibilities as are commensurate with such
position and/or such additional or different duties and responsibilities as the Company’s Board of Directors (“Board”) may reasonably designate from time to time. The Executive shall report directly to the Board. For the avoidance of
doubt, it is the intention to appoint the Executive as a Director of the Company at the first meeting of the Board subsequent to the Effective Date. 

4. Standard of Care. During the Term, Executive (a) will devote his full working time and best efforts to the business and affairs
of the Company; (b) will exercise the highest degree of loyalty and the highest standards of conduct in the performance of his duties; (c) will not, except for as those business activities described in Exhibit A or with the Company’s
written consent, engage in any other business activity, whether or not such business activity is 







 
pursued for gain, profit or other pecuniary advantage; (d) will not engage, directly or indirectly, in any activity that is knowingly competitive with the Company’s business in any
respect or make any preparations to engage in any competitive activities; and (e) will not take any action that knowingly deprives the Company of any business opportunities or otherwise act in a manner that knowingly conflicts with the best
interests of the Company or that is knowingly detrimental to the business of the Company; provided, however, this Section 4 shall not be construed as preventing Executive (i) from investing his personal assets in such form or manner as
will not require his services in the daily operations and affairs of the businesses in which such investments are made, or (ii) from serving on civic or charitable boards or committees, as long as such activities do not interfere with
Executive’s work for the Company. 
 5. Compensation and Benefits. As remuneration for all services to be rendered by Executive
during the Term, and as consideration for complying with the covenants herein, the Company shall pay and provide to Executive the following: 

5.1. Annual Base Salary. During the Term, the Company shall pay Executive a base salary in the initial amount of four
hundred thousand Dollars ($400,000.00) (the “Base Salary”) on an annualized basis, payable in substantially equal monthly installments or in accordance with the Company’s payroll policy for its full-time officers as may be in
effect from time to time. The Company will review the Base Salary approximately annually during the Term to determine, at the discretion of the Company, whether the Base Salary should be increased and, if so, the amount of such adjustment and the
time at which the adjustment should take effect. The term “Base Salary” as used in this Agreement shall refer to the Base Salary as in effect from time to time, including any adjustments. 

5.2. Discretionary Cash Bonus Compensation. In addition to the Base Salary, the Executive shall be entitled during the
Term to participate in the Company’s incentive compensation programs for full-time officers of the Company existing from time to time, including a performance-based bonus program pursuant to which the Executive shall be entitled to receive an
incentive award of up to thirty percent (30%) of his Base Salary on an annualized basis (such target subject to increase from time to time by the Board, in its sole discretion), based on the achievement of certain performance objectives. Such
objectives shall be established annually by mutual written agreement, and the achievement of such objectives shall be assessed (and the amount, if any, of such incentive award shall be determined) annually by the Board. 

5.3. Employee Benefit Plans. Executive shall be eligible to participate in any employee benefit plans and programs to
which employees of the Company are generally entitled to participate, commensurate with Executive’s position with the Company and subject to the eligibility requirements and other terms and conditions of such plans and programs. The Company, in
its sole discretion, may change, amend or discontinue any of its employee benefit plans or programs at any time during Executive’s employment with the Company, and nothing contained herein shall obligate the Company to institute, maintain or
refrain from changing, amending or discontinuing any employee benefit plan or program. 

  
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 5.4. Employee and Consultant Transaction Incentive Plan. As of the
Effective Date, the Company and Executive are subject to the terms and conditions of the Employee and Consultant Transaction Incentive Plan dated August 12, 2009 (the “TIP”). The Executive shall continue to remain eligible as a
Participant (as Participant is defined under the TIP) until termination in conjunction with or amendment of the TIP. At no time during the Term shall the Executive not be a Participant of either the TIP or the Company’s Equity Incentive Plans
as contemplated in Section 5.5. 
 5.5. Participation in the Company’s Equity Incentive Plans. The Executive
shall be entitled during the Term to participate, to the extent and in the manner determined by the Board in its absolute discretion, in any stock option, stock purchase or other equity incentive plans established by the Company, if any, it being
the understanding of the Company and the Executive that such participation would be for the purpose of providing the Executive additional opportunities for equity participation in the Company. For the avoidance of doubt, it is the intention of the
Company to replace the TIP with an Amended and Restated Equity Incentive Plan at the time of the Company’s initial public offering of common stock (the “IPO”). At such time of the IPO, and subject to approval by the Board, the
Executive will receive an initial equity incentive in the amount equal to or greater than four (4) percent of the of the issued and outstanding stock of the Company on a fully diluted basis after having given effect of the issuance of all
shares in conjunction with the IPO (the “Initial Grant”). The Initial Grant shall be considered fifty (50) percent exercisable following the six month anniversary of the IPO. The remaining fifty (50) percent of the Initial Grant
(the “Remainder”) shall become exercisable over a four (4)-year period beginning on the IPO date and continuing during the pendency of the Executive’s employment with the Company, such that the Remainder will become exercisable as to
twenty five percent (25%) of the Remainder on the one- year anniversary of the IPO date and thereafter will become exercisable as to the remaining seventy five percent (75%) of the Remainder in thirty-six (36) approximately equal
monthly installments over the next three years. Any Initial Grant, if they are in the form of stock options, will include an “early exercise” provision with such terms and conditions relating thereto as have been approved generally under
the Amended and Restated Equity Incentive Plan, except that the number of stock option shares eligible for early exercise will be staggered such that no more than that number of stock option shares having an aggregate exercise price of $100,000
shall first become so eligible in any calendar year. 
 5.6. Vacations. During the Term, the Executive shall be
entitled to four (4) weeks of vacation per year, to be taken at such times and intervals as shall be determined by the Executive, subject to the reasonable business needs of the Company. Vacation shall otherwise be governed by the policies of
the Company, as in effect from time to time. 
 6. Reimbursement of Business Expenses. Subject to and consistent with the
Company’s expense reimbursement policies as in effect from time to time, the Company shall pay or reimburse Executive for all reasonable, ordinary and necessary expenses, which Executive incurs in performing his duties under this Agreement.
Such expenses shall be paid or reimbursed to Executive consistent with the expense reimbursement policies of the Company in effect from time to time and Executive agrees to abide by any such expense reimbursement policies. 

  
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 7. Termination. 

7.1. Termination Due to Death. If Executive dies during the Term, this Agreement shall terminate on the date of
Executive’s death. Upon the death of Executive, the Company’s obligation to pay and provide to Executive (or Executive’s estate or other legal successors) compensation and benefits under this Agreement shall immediately terminate,
except that the Company shall pay or provide Executive’s estate or other legal successor the Accrued Benefits and the Death/Disability Benefits. Other than the foregoing, the Company shall have no further obligations to Executive (or
Executive’s estate or other legal successors) under this Agreement. For purposes of this Agreement: 
 (a)
“Accrued Benefits” means (i) that portion of Executive’s Base Salary that was earned as of the termination date; (ii) such cash incentive or bonus compensation that is earned but unpaid, prorated through the
termination date; (iii) any other payments and benefits that have accrued and vested hereunder as of the termination date; and (iv) reimbursement, in accordance with Section 6 of this Agreement, of business expenses incurred prior to
the employment termination date. The Accrued Benefits shall be paid in accordance with the Company’s customary payroll practices and subject to applicable payroll tax withholdings. 

(b) “Death/Disability Benefits” means that portion of Executive’s Base Salary that would have been earned
during the two (2) month period following the termination date if Executive had continued to be employed during such period. The Death/Disability Benefits shall be paid in accordance with the Company’s customary payroll practices and
subject to applicable payroll tax withholdings. 
 7.2. Termination Due to Disability. If Executive suffers a Disability, the Company
may terminate this Agreement and Executive’s employment by providing written notice to Executive of the Company’s termination because of Disability specifying in such notice the effective termination date, and this Agreement and
Executive’s employment will terminate at the end of the day on the termination date specified in the Company’s notice. Upon the termination of this Agreement because of Disability, the Company’s obligation to pay and provide Executive
compensation and benefits under this Agreement will immediately terminate, except that the Company shall pay or provide Executive or his legal guardian or other legal successor the Accrued Benefits and the Death/Disability Benefits. Other than the
foregoing, the Company will have no further obligations to Executive under this Agreement. For purposes of this Agreement: 

(a) “Disability” means any of the following: (i) Executive is deemed disabled and entitled to benefits in
accordance with any Company-provided long- term disability insurance policy or plan covering Executive; (ii) Executive has 

  
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been unable, because of injury, illness, disease or bodily or mental infirmity, to perform, with or without reasonable accommodation, the essential functions of his job for more than ninety
(90) consecutive days; or (iii) upon the written determination by a physician selected by the Company that, because of an injury, illness, disease or bodily or mental infirmity, Executive is unable to perform, with or without reasonable
accommodation, the essential functions of Executive’s job and, as of the date of determination, such condition is reasonably expected to last for a period of ninety (90) consecutive days or longer after the date of determination, based on
the medical information reasonably available to such physician at the time of such determination. In connection with any such determination by a physician, Executive hereby: (x) consents to any examinations by any physician selected by the
Company; (y) agrees to furnish such medical information as may be requested by the Company or its selected physician; and (z) waives any applicable physician-patient privilege that may arise because of any such examination. 

7.3. Termination by the Company For Cause. At any time during the Term, the Company may terminate this Agreement and
Executive’s employment with the Company for Cause by providing Executive with written notice of the Company’s termination for Cause specifying in such notice the termination date, and this Agreement and Executive’s employment will
terminate at the end of the day on the termination date specified in such notice. Upon termination of Executive’s employment by the Company for Cause, the Company’s obligation to pay or provide Executive compensation and benefits under
this Agreement shall terminate, except that the Company shall pay Executive the Accrued Benefits. Other than the foregoing, the Company shall have no further obligations to Executive under this Agreement. For purposes of this Agreement: 

(a) “Cause” means the occurrence of one or more of the following events: (i) Executive’s conviction
for, or pleading no contest to, a felony, any crime involving moral turpitude, or any crime that is injurious to the financial condition, reputation or goodwill of the Company; (ii) Executive’s misappropriation of any of the Company’s
property; (iii) Executive’s engaging in any fraudulent or dishonest conduct in his dealings with, or on behalf of, the Company; (iv) Executive’s failure or refusal to follow the lawful instructions of the Company’s Board of
Directors (other than any such failure or refusal resulting from Executive’s incapacity due to physical or mental illness), if such failure or refusal continues for a period of ten (10) days after the Company provides Executive with
written notice stating the instructions which Executive has failed or refused to follow, or, if cured, upon recurrence thereof; (v) Executive’s breach of his obligations under this Agreement or any other agreement with the Company and such
breach, if curable, remains uncured for a period of ten (10) days after the Company provides Executive with written notice of such breach, or, if cured, upon recurrence thereof; (vi) Executive’s knowing violation of any of the
Company’s written policies or procedures, including, without limitation, any employee policies, business ethics policies or code of conduct policies, and such violation, if curable, remains uncured for a period of ten (10) days after the
Company provides Executive with written notice of such violation or, if cured, 

  
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upon recurrence thereof; (vii) Executive’s engaging in any willful misconduct which is injurious to the financial condition, reputation or goodwill of the Company; or
(viii) Executive’s misuse of alcohol or drugs which materially interferes with Executive’s performance of his duties for the Company or which is injurious to the reputation or goodwill of the Company. 

7.4. Termination by the Company Without Cause. At any time during the Term, the Company may terminate this Agreement and
Executive’s employment with the Company without Cause for any reason or no reason by notifying Executive in writing of the Company’s termination without Cause, specifying in such notice the effective termination date, and this Agreement
and Executive’s employment with the Company shall terminate at the end of the day on the termination date specified in the Company’s notice (or such other date as may be mutually agreed upon by the Company and Executive). Upon termination
of Executive’s employment by the Company without Cause, the Company’s obligation to pay and provide Executive compensation and benefits under this Agreement shall immediately terminate, except that the Company shall pay or provide
Executive the Accrued Benefits and, subject to Sections 7.8 and 7.9 of this Agreement, the Severance Benefits for a period of twelve (12) months after the termination date. Other than the foregoing, the Company shall have no further obligations
to Executive under this Agreement. For purposes of this Agreement: 
 (a) “Severance Benefits” means
(i) salary continuation at the Base Salary rate in effect on the termination date; (ii) an additional monthly severance amount equal to one-twelve (1/12) of the average annual cash bonus the Company paid Executive during the last
three fiscal years prior to the termination date (or if Executive was not employed with the Company for the last three fiscal years, the average shall be calculated using the number of fiscal years Executive has been employed with the Company);
(iii) an additional monthly severance amount equal to One Hundred Forty percent (140%) of the COBRA Premium Rate; (iv) reimbursement of up to ten thousand dollars ($10,000) in total for reasonable outplacement or career transition
services at the Executive’s sole discretion; and (v) the unvested portion of Executive’s then outstanding equity incentive awards that would have vested during the period Severance Benefits are provided will vest immediately and, if
applicable, become exercisable. The Severance Benefits (x) shall be paid in accordance with the Company’s customary payroll practices; (y) are subject to applicable payroll tax withholdings; and (z) are in lieu of any other
severance benefits under any severance policy or plan the Company may have now or in the future, and Executive acknowledges that he is not entitled to any other severance benefits. 

(b) “COBRA Premium Rate” means the monthly amount charged, as of the termination date, for COBRA continuation
coverage under the Company’s group medical and dental plans for the coverage options and coverage levels applicable to Executive and his covered dependents immediately prior to the termination date. 

  
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 7.5. Termination by Executive For Good Reason. At any time during the
Term, Executive may terminate this Agreement and Executive’s employment with the Company by giving the Company written notice of termination for Good Reason specifying in such notice the basis for the Good Reason termination; provided, however,
the Company will have ten (10) days from its receipt of any written notice of the Good Reason termination in which to take corrective action to cure the Good Reason, and if the Company does not cure the Good Reason, the Good Reason termination
will be effective at the end of the tenth (10th) day after the Company receives the written notice of Good Reason termination; and provided further, however, for Executive to exercise his right to terminate for Good Reason, Executive must
provide written notice of termination for Good Reason within thirty (30) days after the occurrence of the event giving rise to the basis for the Good Reason termination. If this Agreement and Executive’s employment are terminated by
Executive for Good Reason, the Company’s obligation to pay or provide Executive compensation and benefits under this Agreement shall terminate, except that the Company shall pay or provide Executive the Accrued Benefits and, subject to Sections
7.8 and 7.9 of this Agreement, the Severance Benefits for a period of twelve (12) months following the termination date. Other than the foregoing, the Company shall have no further obligations to Executive under this Agreement. For purposes of
this Agreement: 
 (a) “Good Reason” means the occurrence of any of the following events without
Executive’s consent: (i) the Company provides Executive with notice of its intention not to extend the term of the Agreement pursuant to Section 2; (ii) the Company decreases Executive’s Base Salary by more than five percent
(5%) in any calendar year and such decrease is not part of a general decrease in base salary applicable to all senior executives; (iii) the Company demotes Executive or assigns Executive to duties that are materially inferior to and
inconsistent with Executive’s position, duties and responsibilities immediately prior to such assignment; (iv) the Company eliminates or materially reduces the employee benefits provided to Executive and such elimination or reduction is
not applicable to all senior executives; (v) the Company relocates Executive’s principal place of employment to a location that is more than thirty (30) miles from Boxford, Massachusetts and from the Company office or facility at
which Executive was based immediately prior to such relocation, it being acknowledged that in the course of Executive’s employment hereunder, Executive shall regularly be required to undertake business travel; (vi) the Company materially
breaches any material term of this Agreement; or (vii) the Company fails to obtain the assumption of the obligation to perform this Agreement by any assignee as contemplated in Section 13.1 hereof. 

7.6. Termination By Executive Without Good Reason. At any time during the Term, Executive may terminate this Agreement
and his employment with the Company for reasons other than Good Reason or for no reason by giving the Company written notice of termination without Good Reason, specifying in such notice a termination date not less than sixty (60) calendar days
after the giving of the notice (the “Executive’s Notice Period”), and Executive’s employment with the Company shall terminate at the end of the day on the last day of Executive’s Notice Period; provided,


  
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however, that in response to Executive’s notice of termination without Good Reason, the Company shall have the right to terminate Executive’s employment with the Company at any time
during the Executive’s Notice Period. Upon termination of Executive’s employment with the Company under this Section 7.6, whether at the end of Executive’s Notice Period or earlier as designated by the Company, the Company’s
obligation to pay Executive compensation and benefits under this Agreement shall immediately terminate, except that the Company shall pay or provide Executive the Accrued Benefits. Other than the foregoing, the Company shall have no further
obligations to Executive under this Agreement. 
 7.7. Qualifying Termination in Connection with a Change in Control.
If at any time within twelve (12) months after a Change in Control of the Company, Executive’s employment under this Agreement is terminated by the Company without Cause or by Executive for Good Reason, the Company’s obligation to pay
or provide Executive compensation and benefits under this Agreement shall terminate, except that the Company shall pay or provide Executive the Accrued Benefits and, subject to Sections 7.8 and 7.9 of this Agreement, the Severance Benefits for a
period of twenty- four (24) months following the termination date (except that the total reimbursement for outplacement or career transition services shall be increased to $20,000); provided, however, that the payment of such Severance Benefits
shall be reduced by the full amount that such payments, when added to all other payments or benefits of any kind to Executive by reason of the Change in Control of the Company, constitutes an “excess parachute payment” within the meaning
of Section 280G of the Internal Revenue Code of 1986, as amended (the “Code”). For the avoidance of doubt, if this Section 7.7 applies, Executive is not entitled to the compensation under Section 7.4 or
Section 7.5. Other than the foregoing, the Company shall have no further obligations to Executive under this Agreement. For purposes of this Agreement: 

(a) “Change in Control” means any of the following events: (i) the acquisition, directly or indirectly,
by any person or group of persons acting in concert, of beneficial ownership of shares of Company stock entitled to exercise a majority of the voting power in the election of directors (“Majority Voting Power”) of the Company;
provided, however, that any financing by existing stockholders of the Company, any venture capital financing or any initial public offering of the Company shall not constitute a Change in Control; (ii) the replacement, during any twelve
(12) month period, of a majority of the Company’s directors by new directors whose appointment or election was not endorsed by a majority of the directors serving at the start of such twelve (12) month period; (iii) stockholder
approval of a reorganization, merger or consolidation of the Company unless, following such transaction, Majority Voting Power of the Company is retained by the persons who were the beneficial owners of the Company’s outstanding voting
securities immediately prior to such transaction (the “Company Stockholders”); (iv) stockholder approval of a complete liquidation or dissolution of the Company; or (v) stockholder approval of the sale or other disposition
of all or substantially all of the assets of the Company, other than to a person or entity with respect to which Majority Voting Power is held by the Company and/or the Company Stockholders. 

  
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 7.8. Severance Release. Executive acknowledges and agrees that the
Company’s payment of the Severance Benefits pursuant to Section 7.4, Section 7.5 or Section 7.7 of this Agreement shall be deemed to constitute a full settlement and discharge of any and all obligations of the Company to
Executive arising out of this Agreement, Executive’s employment with the Company and/or the termination of Executive’s employment with the Company. Executive further acknowledges and agrees that as a condition to receiving any of the
Severance Benefits pursuant to Section 7.4, Section 7.5 or Section 7.7 of this Agreement, Executive will execute and deliver to the Company a Release Agreement in substantially the form attached as Exhibit B (with such changes as may
be necessary due to changes in applicable law), and subsequently not revoke such Release Agreement, pursuant to which Release Agreement Executive will release and waive all claims against the Company, its affiliates, and all of its and their present
and/or former members, owners, officers, directors, employees, agents, attorneys and representatives, including, without limitation, all claims arising out of this Agreement, Executive’s employment with the Company, and/or the termination of
Executive’s employment with the Company; provided, however, that such Release Agreement shall not affect or relinquish any claim for the Accrued Benefits or Severance Benefits to which Executive is entitled pursuant to this Agreement. 

7.9. Forfeiture of Compensation. Executive acknowledges and agrees that if Executive knowingly breaches of any of the
non-disclosure or restrictive covenant provisions set forth in Sections 8 and/or 9 of this Agreement, then in such event Executive will have forfeited his right to receive, and the Company shall have the right immediately and permanently to
discontinue payment of, any Severance Benefits that would otherwise be payable to Executive under Section 7.4, Section 7.5 or Section 7.7 of this Agreement without any recourse by Executive. The Company and Executive acknowledge and
agree that such remedy is in addition to, and not in lieu of, any and all other legal and/or equitable remedies that may be available to the Company in connection with Executive’s breach or threatened breach, of any non-disclosure or
restrictive covenant provision set forth in Sections 8 and 9 of this Agreement. 
 7.10. Effect of Termination of
Employment. In the event Executive’s employment with the Company terminates for any reason (including, without limitation, pursuant to Sections 7.1 – 7.7 herein), Executive agrees and covenants that he will immediately resign, and will
be deemed to have resigned from, any and all positions he may hold with the Company or any of its subsidiaries or affiliates. 

7.11. Effect of Executive’s Death on Severance Benefits. If Executive dies during the period of time he is entitled
to receive the Severance Benefits under Section 7.4, Section 7.5 or Section 7.7, the Company shall pay the remaining Severance Benefits to Executive’s estate (or other legal successor). 

7.12. Separation from Service. Whenever used in this Agreement, the word “terminate” or
“termination” in connection with Executive’s employment shall mean a “separation from service” of Executive from the Company and its affiliates within the meaning of Section 409A of the Code and Treasury Regulation
Section 1.409A-1(h), and Executive’s termination date shall be the date of such separation from service. 

  
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 8. Non-Disclosure of Confidential Information. For purposes of this Agreement, the term
“Confidential Information” means any and all of the Company’s (and its subsidiaries’ or affiliates’) trade secrets, confidential and proprietary information and all other non-public information and data of or about
the Company (and its affiliates) and its business, including, without limitation, lists of customers, information pertaining to customers, marketing plans and strategies, information pertaining to suppliers, information pertaining to prospective
suppliers, pricing information, engineering and technical information, software codes, cost information, data compilations, research and development information, business plans, financial information, personnel information, information received from
third parties that the Company has agreed to keep confidential, and information about prospective customers or prospective products and services, whether or not reduced to writing or other tangible medium of expression, including, without
limitation, work product created by Executive in rendering services for the Company. During Executive’s employment with the Company and thereafter, Executive will not use or disclose to others any of the Confidential Information, except
(a) in the course of Executive’s work for and on behalf of the Company, (b) with the prior written consent of the Company or (c) as required by law or judicial process, provided Executive promptly notifies the Company in writing
of any subpoena or other judicial request for disclosure involving confidential information or trade secrets, and cooperates with any effort by the Company to obtain a protective order preserving the confidentiality of the confidential information
or trade secrets. Executive agrees that the Company owns the Confidential Information, Executive has no rights, title or interest in any of the Confidential Information and that Executive shall and hereby does assign to the Company any right, title
or interest of Executive therein. Additionally, Executive will abide by the Company’s policies protecting the Confidential Information, as such policies may exist from time to time. At the Company’s request or upon termination of
Executive’s employment with the Company for any reason, Executive will immediately deliver to the Company any and all materials (including all copies and electronically stored data) containing any Confidential Information in Executive’s
possession, custody or control. Upon termination of Executive’s employment with the Company for any reason, Executive will, if requested by the Company, provide the Company with a signed written statement disclosing whether Executive has
returned to the Company all materials (including all copies and electronically stored data) containing any Confidential Information previously in Executive’s possession, custody or control. Executive’s confidentiality/non-disclosure
obligations under this Agreement continue after the termination of Executive’s employment with the Company for any reason. With respect to any particular trade secret information, Executive’s confidentiality/non- disclosure obligations
shall continue as long as such information constitutes a trade secret under applicable law. With respect to any particular Confidential Information that does not constitute a trade secret, Executive’s confidentiality/non-disclosure obligations
shall continue for a period of five (5) years, and shall not apply to information that becomes generally known to the public through no fault or action of Executive or others who were under confidentiality obligations with respect to such
information. Executive acknowledges and agrees that his obligations under this Section shall survive the expiration or termination of this Agreement and the cessation of his employment with the Company for whatever reason. Executive further
acknowledges and agrees that his obligations under this Section shall be construed as independent covenants and that no breach of any contractual or legal duty by the Company shall be held sufficient to excuse or terminate Executive’s
obligations under this Section or to preclude the Company from enforcing this Section. 

  
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 9. Restrictive Covenants. The parties acknowledge that in connection with his employment
with the Company, Executive has provided and will continue to provide executive-level services that are of a unique and special value and that Executive has been and will continue to be entrusted with confidential and proprietary information
concerning the Company and its affiliates. The parties further acknowledge that the Company is engaged in a highly competitive business and that the Company expends substantial amounts of time, money and effort to develop trade secrets, business
strategies, customer relationships, employee relationships and goodwill, and Executive will benefit from these efforts. Therefore, as an essential part of this Agreement, the parties agree and covenant to comply with the following restrictive
covenants. 
 9.1. Non-Competition. During the Restricted Time Period, Executive shall not, directly or indirectly,
engage in (including without limitation being employed by, working for, rendering services to or for the benefit of, or advising) a Competitive Business in any executive management capacity anywhere in the world. Notwithstanding the foregoing, if a
Competitive Business is diversified and operates both within and outside the Field, nothing herein is intended to prohibit Executive from being employed by, working for, rendering services to or for the benefit of, or assisting such Competitive
Business outside the Field. For purposes of this Agreement: 
 (a) “Restricted Time Period” means the period
during Executive’s employment with the Company and for the longer of (i) twelve (12) months after the termination of Executive’s employment for any reason, and (ii) any period during which Executive is entitled to receive
Severance Benefits under this Agreement. 
 (b) “Competitive Business” means a business other than the
Company that researches, develops, makes or sells compounds, products or therapies in the Field. 
 (c)
“Field” means the treatment of migraine headache and/or any other indication actively being pursued by the Company in clinical development during the period of Executive’s employment with the Company. 

9.2. Non-Interference With Contractors and Vendors. During the Restricted Time Period, Executive will not urge, induce
or seek to induce any of the Company’s independent contractors, consultants, vendors, suppliers or any other person or entity with whom the Company has a business relationship to terminate their relationship with the Company or to cancel,
withdraw, reduce, limit or in any manner modify any such person’s or entity’s business with the Company. 
 9.3.
Employee Restrictions. During the Restricted Time Period, Executive will not solicit, recruit, hire, employ, attempt to hire or employ, or assist any person or entity in the recruitment or hiring of, any person who is an employee, consultant
or independent contractor of the Company, or otherwise urge, induce or seek to induce any such person to terminate his/her employment or other relationship with the Company. 

  
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 9.4. Non-Disparagement. During the Restricted Time Period, neither party
will make or publish any statements or comments that disparage or injure the reputation or goodwill of the other or of any of its officers, directors or employees; provided, however, nothing herein shall prohibit either party from providing any
information that may be required or compelled by law or legal process. 
 9.5. Direct or Indirect Activities.
Executive acknowledges and agrees that the covenants contained in this Section 9 prohibit Executive from engaging in certain activities directly or indirectly, whether on Executive’s own behalf or on behalf of any other person or
entity, and regardless of the capacity in which Executive is acting, including without limitation as an employee, independent contractor, owner, partner, officer, agent, consultant, or advisor. 

9.6. Survival of Restrictive Covenants. Executive acknowledges and agrees that his obligations under this Section 9
shall survive the expiration or termination of this Agreement and the cessation of his service with the Company for whatever reason. Executive further acknowledges and agrees that his restrictive covenant obligations under this Section 9 shall
be construed as independent covenants and that no breach of any contractual or legal duty by the Company shall be held sufficient to excuse or terminate Executive’s restrictive covenant obligations under this Section 9 or to preclude the
Company from enforcing this Section 9. 
 9.7. Extension. In the event Executive violates any of the restrictive
covenants contained in this Section 9, the duration of all restrictive covenants shall automatically be extended by the length of time during which Executive was in violation of any such restriction. 

9.8. Severability; Reformation of Restrictions. Although Executive and the Company consider the restrictions contained
in this Section 9 to be reasonable, particularly given the competitive nature of the Company’s business and Executive’s position with the Company, Executive and the Company acknowledge and agree that: (a) if any covenant,
subsection, portion or clause of this Section 9 is determined to be unenforceable or invalid for any reason, such unenforceability or invalidity shall not affect the enforceability or validity of the remainder of the Agreement; and (b) if
any particular covenant, subsection, provision or clause of this Section 9 is determined to be unreasonable or unenforceable for any reason, including, without limitation, the time period, geographic area, and/or scope of activity covered by
any restrictive covenant, such covenant, subsection, provision or clause shall automatically be deemed reformed such that the contested covenant, subsection, provision or clause shall have the closest effect permitted by applicable law to the
original form and shall be given effect and enforced as so reformed to whatever extent would be reasonable and enforceable under applicable law. Any court interpreting any restrictive covenant provision of this Agreement shall, if necessary, reform
any such provision to make it enforceable under applicable law. 
 10. Company Property. Executive acknowledges and agrees that all
tangible materials, equipment, documents, copies of documents, data compilations (in whatever form), 

  
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and electronically created or stored materials that Executive receives or makes in the course of her employment with the Company (or with the use of Company time, materials, facilities or trade
secrets or confidential information) are and shall remain the property of the Company. Upon the termination of Executive’s service with the Company, or at the Company’s request, Executive shall immediately deliver to the Company
(i) any and all memoranda, notes, records, drawings, manuals, computer programs, documentation, diskettes, computer tapes, electronic data (in whatever form or media), and all copies thereof, in Executive’s possession or under
Executive’s control, whether prepared by Executive or others, containing any Confidential Information; and (ii) any and all property or equipment belonging to the Company, including, without limitation, keys, access cards, computers, files
and documents. Executive acknowledges and agrees that his obligations under this Section shall survive the expiration or termination of this Agreement and the cessation of his employment with the Company for whatever reason. 

11. Remedies. Executive acknowledges that a breach or threatened breach by Executive of Section 8, Section 9 or
Section 10 of this Agreement will give rise to irreparable injury to the Company and that money damages will not be adequate relief for such injury and, accordingly, Executive agrees that the Company shall be entitled to obtain equitable
relief, including, but not limited to, temporary restraining orders, preliminary injunctions and/or permanent injunctions, without having to post any bond or other security, to restrain or prohibit such breach or threatened breach, in addition to
any other legal remedies which may be available, including the recovery of money damages. 
 12. Intellectual Property. Executive
agrees that any invention, development, concept, enhancement, process, method, improvement or any other creation (collectively “Inventions”) Executive may develop, invent, discover, conceive or originate, alone or jointly with
others, during Executive’s employment with the Company and relating to the Company’s business, or future business which the Company had under consideration while Executive was employed with the Company, shall be promptly and fully
disclosed by Executive to the Company and shall be the Company’s exclusive property. To the extent that the title or rights to any such Inventions may not, by operation of law, vest in the Company, Executive hereby assigns all rights, title and
interest in such Inventions to the Company. Executive further agrees to deliver promptly to Company all papers, files, data and other materials relating to any such Inventions. Executive shall, at the request of the Company and without royalty or
other consideration, execute, acknowledge and deliver to the Company at its expense such written documents or instruments as may be necessary to assign to the Company all patents and other rights in such Inventions and to vest all right, title and
interest to such Inventions in the Company. This Section does not apply to an invention for which no equipment, supplies, facility, or Confidential Information (as defined below) of the Company was used and which was developed entirely on
Executive’s own time, unless (a) the invention relates (i) directly to the business of the Company or (ii) to the Company’s actual or demonstrably anticipated research or development, or (b) the invention results from
any work performed by Executive for the Company. All written, graphic or recorded material and all other works of authorship fixed in a tangible medium of expression (collectively “Works”) made or created by Executive, alone or
jointly with others, during Executive’s employment with the Company and relating to the Company’s business, or future business which the Company had under consideration while Executive was employed with the Company, shall be the exclusive
property of the Company and the Company will have the exclusive right to copyright such Works. Executive agrees that if any 

  
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Works created while employed by the Company, whether or not created at the direction of the Company, is copyrightable, it will be a “work made for hire,” as that term is defined in the
copyright laws of the United States. If, for any reason, any copyrightable Works created by Executive is excluded from that definition, Executive hereby assigns and conveys to the Company all right, title and interest (including any copyright and
renewals) in such Works. Executive agrees that the Company and its licensees are not required to designate Executive as author, inventor or developer of any Works or Inventions when distributed. Executive further agrees that the Company shall have
the sole discretion with regard to how and for what purposes, if any, such Works or Inventions are distributed or used. Executive will sign documents of assignment, declarations and other documents and take all other actions reasonably required by
the Company, at the Company’s expense, to perfect and enforce any of its proprietary rights. The Company shall have the royalty-free right to use in its business, and to use, make and sell products,
processes and/or services derived from, any inventions, discoveries, concepts, and ideas, whether or not patentable, which for whatever reason are determined not to be within the scope of the Inventions defined above but which are conceived or made
by Executive during Executive’s work for the Company or with use or assistance of the Company’s facilities, equipment, Confidential Information or personnel. 

13. Assignment. 

13.1. Assignment by Company. The rights and obligations of the Company under this Agreement shall inure to the benefit
of and be binding upon any and all successors and assigns of the Company, including without limitation by asset assignment, merger, consolidation or other reorganization. As used in this Agreement, “Company” shall mean the Company as
hereinbefore defined and any successor to its business and/or assets which assumes and agrees to perform this Agreement by operation of law, or otherwise. 

13.2. Non-Assignment by Executive. The services to be provided by Executive to the Company hereunder are personal to
Executive, and Executive’s duties may not be assigned by Executive. 
 14. Notice. Any notice required or permitted under this
Agreement shall be in writing and either delivered personally or sent by nationally recognized overnight courier, express mail, or certified or registered mail, postage prepaid, return receipt requested, at the following respective address unless
the party notifies the other party in writing of a change of address: 
 If to the Company: 

CoLucid Pharmaceuticals, Inc. 

Attention: Chairman of the Board of Directors 

PO Box 14401 
 Durham, NC 27709

 If to Executive: 
 Thomas P.
Mathers 
 [Home Address Redacted] 

  
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 A notice delivered personally shall be deemed delivered and effective as of the date of delivery.
A notice sent by overnight courier or express mail shall be deemed delivered and effective the next business day after it is deposited with the postal authority or commercial carrier. A notice sent by certified or registered mail shall be deemed
delivered and effective three (3) days after it is deposited with the postal authority. 
 15. Miscellaneous. 

15.1. Entire Agreement. This Agreement constitutes the entire agreement of the parties with respect to the subjects
addressed herein, and supersedes any prior agreements, understandings, or representations, oral or written, on the subjects addressed herein. 

15.2. Modification. This Agreement shall not be varied, altered, modified, canceled, changed, or in any way amended
except by (a) mutual agreement of the parties in a written instrument executed by Executive and a duly authorized officer or member of the Board of Directors of the Company or (b) reformation by a court as provided in Section 9.8.

 15.3. Counterparts. This Agreement may be executed in one (1) or more counterparts, each of which shall be
deemed to be an original, but all of which together will constitute one and the same Agreement. Signatures transmitted by facsimile or other electronic means shall be effective the same as original signatures for execution of this Agreement. 

15.4. Tax Withholding. The Company may withhold from any compensation or benefits payable under this Agreement all
federal, state, city, or other taxes as may be required pursuant to any law or governmental regulation or ruling. 
 15.5.
Contractual Rights to Benefits. Any benefits payable under this Agreement shall be paid solely from the general assets of the Company. Neither Executive nor Executive’s estate shall have interest in any specific assets of the Company
under the terms of this Agreement. This Agreement shall not be considered to create an escrow account, trust fund or other funding arrangement of any kind between Executive and the Company. Nothing herein contained shall require or be deemed to
require, or prohibit or be deemed to prohibit, the Company to segregate, earmark or otherwise set aside any funds or other assets, in trust or otherwise, to provide for any payments to be made or required hereunder. 

15.6. No Waiver. Failure to insist upon strict compliance with any of the terms, covenants or conditions of this
Agreement shall not be deemed a waiver of such term, covenant or condition, nor shall any waiver or relinquishment of any right or power hereunder at any one or more times be deemed a waiver or relinquishment of such right or power at any other time
or times. 

  
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 15.7. Governing Law; Choice of Forum. To the extent not preempted by
federal law, the provisions of this Agreement shall be construed and enforced in accordance with the laws of the Commonwealth of Massachusetts, notwithstanding any state’s choice-of-law or conflicts-of-law rules to the contrary. The Company and
Executive further acknowledge and agree that this Agreement is intended, among other things, to supplement the provisions of the Uniform Trade Secrets Act, as amended from time to time, and the duties Executive owes to the Company under the common
law, including, but not limited to, the duty of loyalty. The parties agree that any legal action relating to this Agreement shall be commenced and maintained exclusively before any appropriate state court of record in Suffolk County, Massachusetts,
or in the United States District Court for the District of Massachusetts, and the parties hereby submit to the jurisdiction and venue of such courts and waive any right to challenge or otherwise object to personal jurisdiction or venue in any action
commenced or maintained in such courts. 
 15.8. Compliance With Section 409A of the Code. The intent of the
parties is that payments and benefits under this Employment Agreement comply with Section 409A of the Code (“Code Section 409A”), to the extent subject thereto, and, accordingly, to the maximum extent permitted, this
Employment Agreement shall be interpreted and be administered to be in compliance therewith. Notwithstanding anything contained herein to the contrary, to the extent required in order to avoid accelerated taxation and/or tax penalties under Code
Section 409A, Executive shall not be considered to have terminated employment with the Company for purposes of this Employment Agreement until Executive would be considered to have incurred a “separation from service” from the Company
within the meaning of Code Section 409A. Any payments described in this Employment Agreement that are due within the “short-term deferral period” (as defined in Code Section 409A) shall not be treated as deferred compensation
unless applicable law requires otherwise. Each amount to be paid or benefit to be provided to Executive pursuant to this Employment Agreement that constitutes deferred compensation subject to Code Section 409A shall be construed as a separate
identified payment for purposes of Code Section 409A. Notwithstanding anything to the contrary in this Employment Agreement, to the extent that any payments to be made in connection with Executive’s separation from service would result in
the imposition of any individual excise tax and late interest charges imposed under Code Section 409A, the payment shall instead be made on the first business day after the earlier of (a) the date that is six (6) months following such
separation from service or (b) the date of Executive’s death. 
 15.9. Recoupment. 

(a) In the event of a restatement of the Company’s consolidated financial statements, the Board of Directors shall have
the right to take appropriate action to recoup from the Executive any portion of any bonus and other equity or non-equity compensation received by the Executive the payment, grant or vesting of which was tied
to the achievement of one or more specific performance targets, which bonus or other compensation would not have been paid, granted or vested if based on the restated financial statements for the applicable period. This Section 15.9(a) shall
become ineffective at such time as 

  
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the Company adopts a clawback policy pursuant to the requirements of the Dodd- Frank Wall Street Reform and Consumer Protection Act of 2010
(“Dodd-Frank”) which applies to Executive. The Company shall be permitted to request any recoupment at any time during Executive’s employment and for three (3) years thereafter (or such longer period as may be required
pursuant to Dodd-Frank). 
 (b) In the event the Company is entitled to, and seeks,
recoupment under Section 15.9(a) (or under a clawback policy adopted by the Company pursuant to Dodd-Frank), Executive shall no later than sixty (60) days following the request reimburse the amounts
which the Company is entitled to recoup hereunder. If Executive fails to pay such reimbursement, to the extent permitted by applicable law and not in violation of Code Section 409A, the Company shall have the right to (i) offset or deduct
the amount to be reimbursed hereunder from the compensation or other payments due to Executive from the Company or (ii) take any other appropriate action to recoup such payments. 

15.10. No Mitigation. Executive shall not be required to mitigate the amount of any payment or benefit provided for
pursuant to this Agreement by seeking other employment. 
 15.11. Construction. This Agreement is the result of
negotiations between the parties, and neither party shall be deemed to be the drafter of this Agreement. The language of this Agreement shall in all cases be construed as a whole, according to its fair meaning, and not strictly for or against either
party. This Agreement shall be interpreted and construed without any presumption or inference based upon or against the party causing this Agreement to be drafted. 

  
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 IN WITNESS WHEREOF, Executive and the Company have executed this Agreement, intending it to be
effective as of the Effective Date. 
  

							
	COMPANY				EXECUTIVE
			
	COLUCID PHARMACEUTICALS, INC.				THOMAS P. MATHERS
				
	By:		 /s/ Arthur Pappas
				 /s/ Thomas P. Mathers

			Arthur Pappas, Chairman of the Board				Thomas P. Mathers


  
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 EXHIBIT A 

OTHER BUSINESS ACTIVITIES ALLOWED 
  

	1.	Director, Biotechnology Industry Organization (BIO) 

  

	2.	Chairman and Director, Déclion and its affiliates. 


  
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 EXHIBIT B 

RELEASE AGREEMENT 

This Release Agreement (“Release Agreement”) is entered into by and between [EMPLOYER], a Delaware corporation (the
“Company”), and [**NAME**] (“Executive”). 
 Recitals 

A. The Company and Executive are parties to that certain Employment Agreement dated as of
                     (the “Employment Agreement”). Executive’s employment with the Company has terminated effective
                     in accordance with Section      of the Employment Agreement. Pursuant to the terms of the Employment
Agreement, the Company’s obligation to pay, and Executive’s right to receive, certain severance benefits in accordance with Section      of the Employment Agreement is conditional on Executive entering into this
Release Agreement. 
 B. In consideration of Executive’s release and waiver of any and all claims he may have against the Released
Parties (as defined below), including, without limitation, all claims under the Age Discrimination In Employment Act of 1967, as amended (including the Older Workers Benefit Protection Act) (29 U.S.C. § 621 et seq.) (the “Age
Act”), as of the date Executive signs this Release Agreement, the Company is willing to provide certain severance benefits to Executive in accordance with the terms of Section      of the Employment Agreement. 

Agreement 
 In
consideration of the foregoing recitals, the Employment Agreement and the covenants and promises hereby provided, the Company and Executive agree as follows: 

1. General Release of Claims. To the fullest extent permitted by applicable laws, Executive hereby generally, irrevocably and
unconditionally releases and forever discharges and covenants not to sue the Company, all of its affiliated entities, all of its successors and assigns, and all of its and their current and/or former employees, officers, members, managers,
shareholders, owners, directors, trustees, representatives, agents, attorneys, employee benefit plans and their fiduciaries and administrators, and all persons acting by, through, or under or in concert with any of them, both individually and in
their representative capacities (collectively, including without limitation the Company, the “Released Parties”) from any and all claims, demands, liabilities, obligations, injuries, actions or rights of action of any nature
whatsoever, (including without limitation claims for damages, attorneys’ fees, interest and costs), whether known or unknown, disclosed or undisclosed, administrative or judicial, suspected or unsuspected, that exist as of the date Executive
signs this Release Agreement, including, but not limited to: (a) any claims based upon, arising out of or in any manner connected with Executive’s employment with or service for the Company, or the separation of Executive’s employment
with or service for the Company; (b) all claims arising under the Age Act; (c) all claims arising under all other federal, state and local laws; (d) all claims based on contract, tort, common law or other theories of recovery; and
(e) all claims based upon, arising out of or in any 

  
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manner connected with any acts, events or omissions occurring on or before the date Executive signs this Release Agreement; provided, however, Executive and the Company acknowledge and agree that
the foregoing release/covenant not to sue does not release or affect (i) any rights Executive may have with respect to any vested benefits under any employer benefit plans or programs of the Company, (ii) any of Executive’s rights to
severance compensation under Section      of the Employment Agreement, (iii) any claim for Base Salary (as defined in the Employment Agreement) earned by Executive prior to the employment termination date, or
(iv) any claims for reimbursement of business expenses incurred prior to the employment termination date. Executive has been advised by the Company that this Release Agreement does not prohibit Executive from filing an administrative charge of
discrimination with a governmental agency such as the United States Equal Employment Opportunity Commission (“EEOC”) relating to his employment with any of the Released Parties; provided, however, Executive waives and releases, to
the fullest extent permitted by law, any and all entitlement to any form of personal relief arising from such charge or any legal action relating to such charge. Should the EEOC, any other administrative agency or other person bring a complaint,
charge or legal action on Executive’s behalf against any of the Released Parties based on any acts, events or omissions occurring on or before the date Executive signs this Release Agreement, Executive hereby waives any rights to, and will not
accept, any remedy obtained through the efforts of such agency or person. 
 2. Age Act Advisements. Executive acknowledges :
(a) the Company provided Executive with this Release Agreement on                     ; (b) the Company has advised Executive that his
employment with the Company was covered by the Age Act and that by signing this Release Agreement, Executive is releasing and waiving all claims he has against the Released Parties under the Age Act as of the date Executive signs this Release
Agreement; (c) the Company has advised Executive to consult with an attorney prior to signing this Release Agreement; (d) the Company has advised Executive that he has up to twenty-one (21) days
to consider and accept this Release Agreement by signing and returning this Release Agreement to the Company; and (e) the Company has advised Executive that for a period of seven (7) days following Executive’s signing of this Release
Agreement, Executive may revoke this Release Agreement by written notice to the Company; this Release Agreement will not become binding and enforceable until the seven-day revocation period has expired,
without Executive having exercised his revocation right. All notices to the Company shall be directed to the following address: [Employer], Attention:
                    . 
 3. No
Admission. This Release Agreement and the actions taken pursuant to this Release Agreement do not constitute an admission by either party of any wrongdoing or liability, and each party expressly denies any wrongdoing or liability. 

4. Consideration. Executive is entering into this Release Agreement as a condition to receiving certain severance benefits as described
in Section      of the Employment Agreement. Executive acknowledges that he would not be entitled to receive such severance benefits under the Employment Agreement if he did not enter into this Release Agreement. 

5. Governing Law; Choice of Forum. This Release Agreement shall be governed by and construed and enforced in accordance with the laws
of the State of [—], without application of conflict-of-law principles. The parties agree that any legal action relating to this 

  
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Release Agreement shall be commenced and maintained exclusively before any appropriate state court of record in [—] County, [—], or the United States District Court for the [—]; further, the parties hereby irrevocably consent and submit to the jurisdiction and venue of such
courts and waive any right to challenge or object to personal jurisdiction or venue in any action commenced or maintained in such courts relating to this Release Agreement. 

6. Severability. The provisions of this Release Agreement are severable, and the invalidity of any one or more provisions shall not
affect or limit the enforceability of the remaining provisions. Should any covenant or provision be held unenforceable for any reason, then such covenant or provision shall be enforced to the maximum extent permitted by law. 

7. Construction. This Release Agreement is the result of negotiations between the parties, and neither party shall be deemed to be the
drafter of this Release Agreement. The language of this Release Agreement shall in all cases be construed as a whole, according to its fair meaning, and not strictly for or against either party. This Release Agreement shall be interpreted and
construed without any presumption or inference based upon or against the party causing this Release Agreement to be drafted. 
 8.
Counterparts. This Release Agreement may be executed in one or more counterparts (or upon separate signature pages bound together into one or more counterparts), all of which taken together shall constitute but one agreement. Signatures
transmitted by facsimile or other electronic means shall be effective the same as original signatures for execution of this Release Agreement. 

9. Acknowledgment. Executive acknowledges that he has read this Release Agreement, that he has had ample opportunity to consult with
his own attorney concerning this Release Agreement, and that he is knowingly and voluntarily entering into this Release Agreement. 
 IN
WITNESS WHEREOF, Executive and the Company have executed this Release Agreement on the date(s) indicated below, intending it to become effective as set forth above. 
  

									
	EXECUTIVE				[EMPLOYER]
				
	  
				By:		  

	[**NAME*]						[**NAME**], [**TITLE**]
					
	Date:		  
				Date:		  



  
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