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UNITED STATESSECURITIES AND EXCHANGE COMMISSIONWashington, D.C.
20549

FORM 10-K/A(Amendment No. 1)

[X]   ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d)
OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended December 31, 2010

[  ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d)
OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from __________ to 
__________

Commission File Number: 000-31187

IntelGenx Technologies Corp.(Exact name of registrant as specified in its charter)

|Delaware                                                             | 87-0638336                          
|-------------------------------------------------------------------- | ------------------------------------
|(State or other jurisdiction of incorporation or
      organization) | (I.R.S. Employer Identification No.)
|                                                                     |                                     
|6425 Abrams, Ville Saint Laurent, Quebec                             | H4S 1X9                             
|(Address of principal executive offices)                             | (Zip Code)                          

(514) 331-7440(Registrants telephone number,
including area code)

Securities registered pursuant to Section 12(b) of the Act:
NoneSecurities registered pursuant to Section 12(g) of the
Act:Common Stock, $0.00001 par value per share

Indicate by check mark if the registrant is a well-known
seasoned issuer, as defined in Rule 405 of the Securities Act.

Yes [  
]          No  [X]

Indicate by check mark if the registrant is not required to
file reports pursuant to Section 13 or Section 15(d) of the Act.

Yes [  
]          No [X]

Indicate by check mark whether the registrant (1) has filed all
reports required to be filed by Section 13 or 15(d) of the Securities Exchange
Act of 1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days.

Yes [X]          
No [   ]

Indicate by check mark whether the registrant has submitted
electronically and posted on its corporate Web site, if any, every Interactive
Data File required to be submitted and posted pursuant to Rule 405 of Regulation
S-T (§232.405 of this chapter) during the preceding 12 months (or for such
shorter period that the registrant was required to submit and post such files).

Yes [X]          No
[   ]

Indicate by check mark if disclosure of delinquent filers
pursuant to Item 405 of Regulation S-K (§229.405 of this chapter) is not
contained herein, and will not be contained, to the best of registrants
knowledge, in definitive proxy or information statements incorporated by
reference in Part III of this Form 10-K or any amendment to this Form
10-K.  [X]

Indicate by check mark whether the registrant is a large
accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller
reporting company. See the definitions of large accelerated filer,
accelerated filer, and smaller reporting company in Rule 12b-2 of the
Exchange Act. (Check one):

|Large accelerated filer [  ] | Accelerated filer [  ] | Non-accelerated filer [  ]                          | Smaller reporting company [X]
|---------------------------- | ---------------------- | --------------------------------------------------- | -----------------------------
|                             |                        | (Do not check if a smaller
      reporting company) |                              

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Indicate by check mark whether the registrant is a shell
company (as defined in Rule 12b-2 of the Act).

Yes [  ]        No
[X]

As of June 30, 2010, the aggregate market value of the
registrants voting and non-voting common equity held by non-affiliates of the
registrant was $11,302,636 based on the closing price of the registrants common
shares of U.S. $0.50, as reported on the OTC Bulletin Board on that date. Shares
of the registrants common shares held by each officer and director and each
person who owns 10% or more of the outstanding common shares of the registrant
have been excluded in that such persons may be deemed to be affiliates. This
determination of affiliate status is not necessarily a conclusive determination
for other purposes.

Indicate the number of shares outstanding of each of the
registrants classes of common stock, as of the latest practicable date.

|Class                                 | Outstanding at September 20, 2011
|------------------------------------- | ---------------------------------
|Common Stock,
      $.00001 par value | 46,849,910 shares                

Documents incorporated by reference: None.

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EXPLANATORY NOTE

IntelGenx Technologies Corp. (the Company) is filing this
Amendment No. 1 to its Annual Report on Form 10-K/A for the fiscal year ended
December 31, 2010, which was originally filed with the Securities and Exchange
Commission (the Commission) on March 29, 2011 (the Original Form 10-K), to
incorporate the Companys revisions and responses to letters of comment from the
staff of the Commission dated as of August 4, 2011, August 31, 2011 and
September 14, 2011.

This Form 10-K/A includes new certifications as Exhibits 31.1,
31.2, 32.1 and 32.2 by the Companys principal executive officer and principal
financial officer as required by Rules 12b-15 and 13a-14 promulgated under the
Securities Exchange Act of 1934, as amended (the Exchange Act). Except for the
amended disclosures set forth below, the information in this Form 10-K/A has not
been updated to reflect events that occurred after March 29, 2011, the filing
date of the Original Form 10-K. Accordingly, this Form 10-K/A should be read in
conjunction with the Original Form 10-K and the Companys filings made with the
Commission subsequent to the filing of the Original Form 10-K, including any
amendments to those filings. The following sections have been amended
herein:

Part I, Item 1. Business; and

Part IV, Item 15. Exhibits, Financial Statements Schedules.

We have expanded upon the final column of the table on page 9
of the Original Form 10-K to disclose the exact expiration date of each of the
Companys four issued patents. In addition, we have disclosed the material terms
of the License and Development Agreement with Azur Pharma International II Ltd.
on page 5 of the Original Form 10-K, which is filed as Exhibit 10.34 to this
Form 10-K/A (confidential treatment has been requested for certain parts of this
agreement, which are omitted and filed separately with the Commission).

This Form 10-K/A contains only the sections to the Original
Form 10-K which are being amended, and those unaffected sections are not
included herein. Except as set forth above, all other information in the
Companys Original Form 10-K remains unchanged.

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PART I

Cautionary Statement Concerning
Forward-Looking Statements

Certain statements included or incorporated by reference in
this report constitute forward-looking statements within the meaning of
applicable securities laws. All statements contained in this report that are not
clearly historical in nature are forward-looking, and the words anticipate,
believe, continue, expect, estimate, intend, may, plan, will,
shall and other similar expressions are generally intended to identify
forward-looking statements within the meaning of Section 27A of the Securities
Act and Section 21E of the Securities Exchange Act of 1934. All forward-looking
statements are based on our beliefs and assumptions based on information
available at the time the assumption was made. These forward-looking statements
are not based on historical facts but on managements expectations regarding
future growth, results of operations, performance, future capital and other
expenditures (including the amount, nature and sources of funding thereof),
competitive advantages, business prospects and opportunities. Forward-looking
statements involve significant known and unknown risks, uncertainties,
assumptions and other factors that may cause our actual results, levels of
activity, performance or achievements to differ materially from those implied by
forward-looking statements. These factors should be considered carefully and
prospective investors should not place undue reliance on the forward-looking
statements. Although the forward-looking statements contained in this report or
incorporated by reference herein are based upon what management believes to be
reasonable assumptions, there is no assurance that actual results will be
consistent with these forward-looking statements. These forward-looking
statements are made as of the date of this report or as of the date specified in
the documents incorporated by reference herein, as the case may be. The
Company undertakes no obligation to update any forward-looking statements to
reflect events or circumstances after the date on which such statements were
made or to reflect the occurrence of unanticipated events, except as may be
required by applicable securities laws. The factors set forth in Item 1A.,
"Risk Factors", as well as any cautionary language in this report, provide
examples of risks, uncertainties and events that may cause IntelGenx' actual
results to differ materially from the expectations IntelGenx describes in our
forward-looking statements. Before you invest in the common stock, you should be
aware that the occurrence of the events described as risk factors and elsewhere
in this report could have a material adverse effect on our business, operating
results and financial condition.

ITEM 1. BUSINESS.

Corporate History

Our predecessor company, Big Flash Corp., was incorporated in
Delaware on July 27, 1999. On April 28, 2006, Big Flash, through its Canadian
holding corporation, completed the acquisition of IntelGenx Corp., a Canadian
company incorporated on June 15, 2003. The Company did not have any operations
prior to the acquisition of IntelGenx Corp. In connection with the acquisition,
we changed our name from Big Flash Corp. to IntelGenx Technologies Corp.
IntelGenx Corp. has continued operations as our operating subsidiary.

Overview

We are a drug delivery company focusing on the development of
novel, orally administered drug delivery products based on our proprietary oral
drug delivery technologies. We have positioned ourselves as a provider of
product development services for the pharmaceutical industry, including the
branded and generic pharmaceutical markets.

Drug delivery systems are an important tool in the hands of
physicians for purposes of optimizing drug therapy. For the pharmaceutical
industry, drug delivery systems represent an opportunity to extend the market
exclusivity and product lifecycle of drugs whose patent protection is nearing
expiration.

Controlled release (CR) delivery systems play an important role
in the development of orally administered drug delivery systems. Controlled
release technology provides patients with the required amount of medication over
a pre-determined, prolonged period of time. Because of the reduced fluctuation
of the active drug in the blood and the avoidance of plasma spikes, controlled
release products are deemed safer and more tolerable than conventional dosage
forms, and have shown better patient compliance.

Our primary business strategy is to develop pharmaceutical
products based upon our proprietary drug delivery technologies and license the
commercial rights to companies in the pharmaceutical industry once the viability
of a product has been demonstrated. In exchange for licensing rights to our
products, we seek funding consisting of a combination of one or more of the
following: advance down payments, milestone fees, reimbursement for development
costs, and royalties on sales. In addition, we may receive a manufacturing
royalty from our contract manufacturers for the exclusive right to manufacture
our products. The companies we partner with are typically responsible for
managing the regulatory approval process of the product with the United States
Food and Drug Administration (FDA) and/or other regulatory bodies, as well as
for the marketing and distribution of the products. On a case-by-case basis,
IntelGenx may be responsible for providing all or part of the documentation
required for the regulatory submission. In addition to pursuing partnering arrangements that provide for the full
funding of a drug development project, we may undertake development of selected
product opportunities until the marketing and distribution stage. We would first
assess the potential and associated costs for successful development of a
product, and then determine at which stage it would be most prudent to seek a
partner, balancing costs against the potential for higher returns later in the
development process.

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Technology Platforms

Our product development efforts are based upon three delivery
platform technologies: (1) a Multilayer Tablet technology (2) an Oral Film
technology, and (3) a Mucoadhesive Tablet technology. Our Multilayer Tablet
platform technology allows for the development of oral controlled-release
products. It is designed to be versatile and to reduce manufacturing costs as
compared to competing oral extended-release delivery technologies. The Oral Film
technology allows for the instant delivery of pharmaceuticals to the oral
cavity, while the Mucoadhesive Tablet allows for the controlled release of
active substances to the oral mucosa.

The Multilayer Tablet (VersaTab) platform technology
represents a new generation of controlled release layered tablets designed to
modulate the release of active compounds. The technology is based on a
multilayer tablet with an active core layer and erodible cover layers. The
release of the active drug from the core matrix initially occurs in a
first-order fashion. As the cover layers start to erode, their permeability for
the active ingredient through the cover layers increases. Thus, the Multilayer
Tablet can produce quasi-linear (zero-order) kinetics for releasing a chemical
compound over a desired period of time. The erosion rate of the cover layers can
be customized according to the physico-chemical properties of the active drug.
In addition, our multilayer technology offers the opportunity to develop
combination products in a regulatory-compliant format. Combination products are
made up of two or more active ingredients that are combined into a single dosage
form.

The Oral Film technology (VersaFilm) is made up of a thin
(25-35 micron) polymeric film comprised of United States Pharmacopeia (USP)
components that are approved by the FDA for use in food, pharmaceutical, and
cosmetic products. Derived from the edible film technology used for breath
strips and initially developed for the instant delivery of savory flavors to
food substrates, the VersaFilm technology is designed to provide a rapid
response compared to existing conventional tablets. The VersaFilm technology is
intended for indications requiring rapid onset of action, such as migraine,
motion sickness, erectile dysfunction, and nausea.

The Mucoadhesive Tablet (AdVersa) is a drug delivery system
capable of adhering to the oral mucosa and releasing the drug onto the site of
application at a controlled rate. The Mucoadhesive Tablet is designed to provide
the following advantages relative to competing technologies: (i) it avoids the
first pass effect, whereby the liver metabolizes the active ingredient and
greatly reduces the level of drug in the systemic circulation, (ii) it leads to
a higher absorption rate in the oral cavity as compared to the conventional oral
route, and (iii) it achieves a rapid onset of action for the drug. The
Mucoadhesive Tablet technology is designed to be versatile in order to permit
the site of application, residence time, and rate of release of the drug to be
modulated to achieve the desired results.

Product Portfolio

Our product portfolio includes a blend of generic and branded
products based on our proprietary delivery technology (generic drugs are
essentially copies of drugs that have already received FDA approval).

INT0001/2004. This is the most advanced generic product
involving our multilayer tablet technology. Equivalency with the reference
product Toprol XL and its European equivalent Beloc-ZOK has been demonstrated
in-vitro. The product has been tested in phase I studies. Pivotal
development activities are ongoing.

INT0004/2006. The development of a new, higher strength of the
antidepressant Bupropion HCl, the active ingredient in Wellbutrin XL®, has been
completed. A regulatory file for a 505(b)(2) New Drug Application (NDA)
submission was filed in April, 2009. In a complete response letter received on
February 4, 2010, the FDA commented on the food effect, which was observed in
the food effect study included in the NDA, and on the lack of a commercial
manufacturer. Both issues have been resolved with new pivotal batches being
manufactured by Pillar5 Pharma and, using product from these pivotal batches, a
new clinical study is being undertaken to address the food effect. A response to
the complete response letter is expected to be filed in the second quarter of
2011.

INT0006/2005. On December 10, 2007, we entered into a license
and development agreement with Azur Pharma for the development and manufacture
of a prenatal vitamin supplement using product specific intellectual property
that we developed. Under the terms of the agreement, Azur Pharma has obtained
certain exclusive rights to market and sell the product using our proprietary,
controlled-release delivery technology in the United States. In exchange for
granting Azur Pharma such rights, we will receive an annual single digit
percentage royalty of all net sales. The term of the agreement is 15 years from
the effective date of May 1, 2007, unless otherwise terminated in the event of,
without limitation (i) failure by either us or Azur Pharma to perform our
respective obligations under the agreement; (ii) if either party files a
petition for bankruptcy or insolvency or otherwise winds up, liquidates or
dissolves its business, or (iii) otherwise by mutual consent of the parties.
The agreement also contains customary confidentiality, indemnification and
intellectual property protection provisions.

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The product was launched in the United States during the fourth
quarter of 2008 under the brand name Gesticare®. As of December 31, 2010, we
have received upfront, milestone and development fees totaling approximately
$1.4 million and royalty income totaling approximately $0.5 million. We do not
anticipate receiving additional milestone payments under the agreement.

INT0010/2006. We initially entered into an agreement with
Cynapsus Therapeutics Inc. (formerly Cannasat Therapeutics Inc., Cynapsus) for
the development of a buccal mucoadhesive tablet product containing a
cannabinoid-based drug for the treatment of neuropathic pain and nausea in
cancer patients undergoing chemotherapy. A clinical biostudy undertaken in 2009
on the mucoadhesive tablet developed by IntelGenx indicated improved
bioavailability and reduced first-pass metabolization of the drug. In the
4th quarter of 2010, we acquired from Cynapsus full control of, and
interest in, this project going forward. We also obtained worldwide rights to US
Patent 7,592,328 and all corresponding foreign patents and patent applications
to exclusively develop and further provide intellectual property protection for
this project. We are preparing pivotal activities, including manufacturing
scale-up and a clinical efficacy study.

INT0007/2006. An oral film product based on our proprietary
edible film technology is currently in the optimization stage. The product is
intended for the treatment of erectile dysfunction (ED). The results of a phase
I pilot study that was conducted in the third quarter of 2010 indicate that the
product is bioequivalent with the reference listed drug.

INT0008/2007. An oral film product based on our proprietary
edible film technology is currently in the pivotal stage of development, with
pivotal batch manufacturing expected to be completed in the third quarter of
2011. The product is intended for the treatment of migraine. The results of a
phase I pilot study that was conducted in 2009 indicate that the product is
bioequivalent with the reference listed drug. In the third quarter of 2010, we
entered into an agreement with RedHill Biopharma Ltd. for the co-development and
commercialization of this product.

INT0019/2009. An oral film product based on our proprietary
edible film technology is currently in the early development stage. The product
is intended for the treatment of diarrhea.

INT0020/2010. An oral film product based on our proprietary
edible film technology is currently being tested for bioequivalence against the
reference listed drug. Results are expected in the first half of 2011. The
product is intended for the treatment of insomnia.

INT0022/2010. An oral film product based on our proprietary
edible film technology is currently in the final stages of optimization. The
results of a phase I pilot study that was conducted in 2010 indicate that the
product is bioequivalent with the reference listed drug. The product is intended
for the treatment of bipolar disorder.

INT0024/2010. An oral tablet product based on our proprietary
multilayer tablet technology is currently in the early development stage. The
product is intended for the treatment of idiopathic pulmonary fibrosis.

INT0025/2010. An oral controlled release film product based on
our proprietary edible film technology is currently in the early development
stage. The product is intended for the treatment of benign prostatic
hyperplasia.

INT0026/2011. An oral film product based on our proprietary
edible film technology is currently in the early development stage. The product
is intended for the treatment of benign prostatic hyperplasia.

The current development status of each of our products as of
the date of this report is summarized in the following table:

|Product      | Application                                      | Status of Development                                                                                                                                                                                                                                                                
|------------ | ------------------------------------------------ | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|INT0001/2004 | CHF (Coronary Heart
      Failure), Hypertension | Pivotal batches in
      preparation.                                                                                                                                                                                                                                                
|INT0004/2006 | Antidepressant                                   | NDA filed April, 2009; complete response letter
      received Q1/2010. Pivotal batches completed at new manufacturing facility.
      Pivotal Phase I clinical study completed and ongoing stability study to
      support filing of response to complete response letter Q2, 2011.
|INT0006/2005 | Prenatal vitamin supplement                      | Product launched in USA Q4, 2008.                                                                                                                                                                                                                                                    
|INT0010/2006 | Neuropathic pain                                 | Pilot biostudy completed. Pivotal activities in
      preparation.                                                                                                                                                                                                                   

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|INT0007/2006 | Erectile Dysfunction          | Pilot biostudy completed indicating bioequivalence
      with Reference Listed Drug (RLD).    
|------------ | ----------------------------- | ----------------------------------------------------------------------------------------------
|INT0008/2007 | Migraine                      | Pilot biostudy completed indicating bioequivalence
      with RLD. Pivotal activities ongoing.
|INT0019/2009 | Diarrhea                      | Formulation development ongoing.                                                              
|INT0020/2010 | Insomnia                      | Formulation development completed. Proof of concept
      clinical study ongoing.             
|INT0022/2008 | Bipolar Disorder              | Pilot biostudy completed indicating bioequivalence
      with RLD.                            
|INT0024/2010 | Idiopathic pulmonary fibrosis | Formulation development ongoing.                                                              
|INT0025/2010 | Benign prostatic hyperplasia  | Formulation development ongoing.                                                              
|INT0026/2011 | Benign prostatic hyperplasia  | Formulation development ongoing.                                                              

Growth Strategy

Our primary growth strategies include: (1) identifying
lifecycle management opportunities for existing blockbuster products, (2)
developing generic drugs with high barriers to entry, (3) developing products
for the (non-pharmaceutical) nutritional supplement market, and (4) developing
new drug delivery technologies.

Lifecycle Management Opportunities

We are seeking to position our delivery technologies as an
opportunity for lifecycle management of products for which patent protection of
the active ingredient is nearing expiration. While the patent for the underlying
substance cannot be extended, patent protection can be obtained for a new and
improved formulation by filing an application with the FDA under Section
505(b)(2) of the U.S. Federal Food, Drug and Cosmetic Act. Such applications,
known as a 505(b)(2) NDA, are permitted for new drug products that incorporate
previously approved active ingredients, even if the proposed new drug
incorporates an approved active ingredient in a novel formulation or for a new
indication. A 505(b)(2) NDA may include information regarding safety and
efficacy of a proposed drug that comes from studies not conducted by or for the
applicant. The first formulation for a respective active ingredient filed with
the FDA under a 505(b)(2) application may qualify for up to three years of
market exclusivity upon approval. Based upon a review of past partnerships
between third party drug delivery companies and pharmaceutical companies,
management believes that drug delivery companies which possess innovative
technologies to develop these special dosage formulations present an attractive
opportunity to pharmaceutical companies. Accordingly, we believe these so-called
505(b)(2) products represent a viable business opportunity for us.

Generic Drugs with High Barriers to Entry

We will also plan to pursue the development of generic drugs
that have certain barriers to entry, e.g., where product development and
manufacturing are complex and can limit the number of potential entrants into
the generic market. We plan to pursue such projects only if the number of
potential competitors is deemed relatively insignificant.

Nutritional Supplement Products

We plan to develop additional products for the nutritional
supplement market based upon our proprietary drug delivery technologies. The
market for these supplements is large, with little differentiation between
products. Our proprietary technology is aimed at increasing the absorption rate
of active ingredients. We believe that supplements represent attractive
short-term revenue opportunities since they are not regulated as pharmaceutical
products and do not require FDA approval.

Development of New Drug Delivery Technologies

The rapidly disintegrating film technology contained in our
VersaFilm, and our AdVersa mucosal adhesive tablet, are two examples of our
efforts to develop alternate technology platforms. As we work with various
partners on different products, we seek opportunities to develop new proprietary
technologies.

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Competition

The pharmaceutical industry is highly competitive and is
subject to the rapid emergence of new technologies, governmental regulations,
healthcare legislation, availability of financing, patent litigation and other
factors. Many of our competitors, including Valeant Pharmaceuticals
International, Inc. (formerly Biovail Corporation), Labopharm Inc., Monosol Rx,
Labtec GmbH and Skye Pharma PLC, have longer operating histories and greater
financial, technical, marketing, legal and other resources than we have. In
addition, many of our competitors have significantly greater experience than we
have in conducting clinical trials of pharmaceutical products, obtaining FDA and
other regulatory approvals of products, and marketing and selling products that
have been approved. We expect that we will be subject to competition from
numerous other companies that currently operate or are planning to enter the
markets in which we compete.

The key factors affecting the development and commercialization
of our drug delivery products are likely to include, among other factors:

- The safety and efficacy of our products;
- The relative speed with which we can develop products;
- Generic competition for any product that we develop;
- Our ability to defend our existing intellectual property and to broaden
  our intellectual property and technology base;
- Our ability to differentiate our products;
- Our ability to manufacture our products in compliance with current Good
  Manufacturing Practices (cGMP) and any other regulatory requirements; and
- Our ability to obtain financing.

In order to establish ourselves as a viable industry partner,
we plan to continue to invest in our research and development activities in
order to further strengthen our technology base and to develop the ability to
manufacture our products through our manufacturing partner at competitive
costs.

Our Competitive Strengths

We believe that our key competitive strengths include:

- Our intellectual property;
- The versatility of our drug delivery technology; and
- The potential manufacturing cost savings associated with our technology.

Manufacturing Partnership

We manufacture products only for testing purposes in our own
laboratories, and we do not manufacture products for clinical trials or for
commercial use.

We formed a strategic alliance with LTS Lohmann
Therapie-Systeme AG ("LTS") for the exclusive manufacturing of products
developed by us using our VersaFilm drug delivery technology. LTS is regarded as
a pioneer in the development and production of transdermal and film form/wafer
oral systems and has become one of the world's leading suppliers for the
international pharmaceutical industry. VersaFilm is IntelGenx' immediate release
wafer technology. It is comprised of a thin polymeric film using United States
Pharmacopeia (USP) components that are safe and approved by the FDA for use in
food, pharmaceutical and cosmetic products. VersaFilm provides a
patent-protected method of re-formulating approved pharmaceuticals in a more
convenient and discrete oral dosage form.

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We formed a strategic manufacturing partnership with, and took
an ownership position in, Pillar5 Pharma Inc. (Pillar5). We have undertaken to
use our best efforts to ensure that distributors of our oral solid dose
pharmaceutical products that are developed for commercial production, be
directed to Pillar5 for the purpose of negotiating a manufacturing agreement
requiring Pillar5 to manufacture such products. As consideration for this
undertaking, Pillar5 issued to us common shares representing 10% of the issued
and outstanding shares of Pillar5.This manufacturing partnership secures the
production of clinical test batches and commercial products for our VersaTab and
AdVersa tablet products.

We are not a manufacturer and we do not usually purchase large
quantities of raw materials. Our manufacturing partners, however, may purchase
significant quantities of raw materials, some of which may have long lead times.
If raw materials cannot be supplied to our manufacturing partners in a timely
and cost effective manner, our manufacturing partners may experience delays in
production that may lead to reduced supplies of commercial products being
available for sale or distribution. Such shortages could have a detrimental
effect on sales of the products and a corresponding reduction on our royalty
revenues earned.

Dependence on Major Customers

We do not rely on any one or a few major customers for our end
products. However, we depend upon a limited number of partners to develop our
products, to provide funding for the development of our products, and to assist
in obtaining regulatory approvals that are required in order to commercialize
these products.

Intellectual Property and Patent Protection

We protect our intellectual property and technology by using
the following methods: (i) applying for patent protection in the United States
and in the appropriate foreign markets, (ii) non-disclosure agreements, license
agreements and appropriate contractual restrictions and controls on the
distribution of information, and (iii) trade secrets, common law trademark
rights and trademark registrations. We plan to file core technology patents
covering the use of our platform technologies in any pharmaceutical
products.

We have obtained four (4) patents and have an additional seven
(7) pending patent applications, as described below. The patents expire 20 years
after submission of the initial application.

|Patent No.                                 | Title                                                                  | Subject                                                                                                                                  | Date submitted / issued /
      expiration    
|------------------------------------------ | ---------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------------------------------- | ----------------------------------------------
|US 6,231,957                               | Rapidly
      disintegrating flavor wafer for flavor enrichment        | The
      composition, manufacturing, and use of rapidly disintegrating flavored
      films for releasing flavors to certain substrates | Issued May 15, 2001
      Expires May 6, 2019 
|US 6,660,292                               | Rapidly disintegrating film for
      precooked foods                  | Composition and manufacturing of
      flavored films for releasing flavors to precooked food substrates                                 | Issued December 9, 2003 Expires June 19, 2021 
|US 7,132,113                               | Flavored film                                                          | Composition and
      manufacturing method of multi-layered films                                                                        | Issued April 16, 2002 Expires April 16, 2022  
|US Appl. 2007/0190144                      | Multilayer Tablet                                                      | Formulation and Method of Preparation
      of Multilayered Tablets                                                                      | Published August 16, 2007                     
|US Appl. 2007/0128272                      | Multi-Vitamin And
      Mineral Supplement                             | Formulation and
      Method of Preparation of Prenatal Multivitamin Supplement                                                          | Published June 7, 2007                        
|US Appl. 2006/0127478                      | Oral dosage formulation                                                | Multilayer oral dosage forms                                                                                                             | Published June 15, 2006                       
|US Appl. 11/782,838
      PCT/IB2007/03950 | Controlled Release
      Pharmaceutical Tablets                        | Formulation and
      Method Of Making Tablets Containing Bupropion And Mecamylamine                                                     | July 25, 2006                                 
|US Patent 7674479                          | Sustained-release Bupropion and
      Bupropion / Mecamylamine tablets | Formulation and Method Of Making
      Tablets Containing Bupropion And Mecamylamine                                                     | Issued March 9, 2010
    Expires July 25, 2027

9

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|US
      Appl.12/836810                      | Oral Mucoadhesive dosage form                                                  | Direct compression formulation for buccal and sublingual
      dosage forms | July 15, 2010   
|-------------------------------------------- | ------------------------------------------------------------------------------ | --------------------------------------------------------------------------- | ----------------
|US
      Appl. 
    US 12/936.132            | Oral film dosage forms and methods for making same                             | Optimization of Film strip technology                                       | December 8, 2010
|US
      Provisional Appl. 
    US 61/327969 | Methods for making improved solid oral dosage forms comprising
      Tadalafil | Oral films containing Tadalafil                                             | April 26, 2010  

Government Regulation

The pharmaceutical industry is highly regulated. The products
we participate in developing require certain regulatory approvals. In the United
States, drugs are subject to rigorous regulation by the FDA. The U.S. Federal
Food, Drug, and Cosmetic Act, and other federal and state statutes and
regulations, govern, among other things, the research, development, testing,
manufacture, storage, record keeping, packaging, labeling, adverse event
reporting, advertising, promotion, marketing, distribution, and import and
export of pharmaceutical products. Failure to comply with applicable regulatory
requirements may subject a company to a variety of administrative or
judicially-imposed sanctions and/or the inability to obtain or maintain required
approvals or to market drugs. The steps ordinarily required before a new
pharmaceutical product may be marketed in the United States include:

- preclinical laboratory tests, animal studies and formulation studies under
  FDAs good laboratory practices regulations, or GLPs;
- the submission to the FDA of an investigational new drug application, or
  IND, which must become effective before human clinical trials may begin;
- the completion of adequate and well-controlled clinical trials according
  to good clinical practice regulations, or GCPs, to establish the safety and
  efficacy of the product for each indication for which approval is sought;
- after successful completion of the required clinical testing, submission
  to the FDA of a New Drug Application, or NDA, or an Abbreviated New Drug
  Application, or ANDA, for generic drugs. In certain cases, an application for
  marketing approval may include information regarding safety and efficacy of a
  proposed drug that comes from studies not conducted by or for the applicant.
  Such applications, known as a 505(b)(2) NDA, are permitted for new drug
  products that incorporate previously approved active ingredients, even if the
  proposed new drug incorporates an approved active ingredient in a novel
  formulation or for a new indication;
- satisfactory completion of an FDA inspection of the manufacturing facility
  or facilities at which the product is produced to assess compliance with cGMPs
  to assure that the facilities, methods and controls are adequate to preserve
  the drugs identity, strength, quality and purity; and
- FDA review and approval of the NDA or ANDA.

The cost of complying with the foregoing requirements,
including preparing and submitting an NDA or ANDA, may be substantial.

Accordingly, we typically rely upon our partners in the
pharmaceutical industry to spearhead and bear the costs of the FDA approval
process. We also seek to mitigate regulatory costs by focusing on 505(b)(2) NDA
opportunities. By applying our drug delivery technology to existing drugs, we
seek to develop products with lower research & development (R&D)
expenses and shorter time-to-market timelines as compared to regular NDA
products.

Research and Development Expense

Our R&D expenses, net of R&D tax credits, for the year
ended December 31, 2010 increased to $1,565 thousand as compared to $1,237
thousand for the year ended December 31, 2009. The increase in R&D
expenditure is explained in the section of this report entitled Managements
Discussion and Analysis of Financial Condition and Results of Operations.

Environmental Regulatory Compliance

We believe that we are in compliance with environmental
regulations applicable to our research and development facility located in Ville
Saint-Laurent, Quebec.

Employees

As of the date of this filing, we have 10 full-time and no
part-time employees. None of our employees are covered by collective bargaining
agreements. We believe that our relations with our employees are good.

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PART IV

ITEM 15. EXHIBITS, FINANCIAL STATEMENT SCHEDULES(a)
Financial Statements and Schedules 1. Financial Statements

The following financial statements are filed as part of the
Original Form 10-K under Item 8 of Part II Financial Statements and
Supplementary Data:

|A. | Report of Independent Registered Public Accounting
      Firm.                                                     
|-- | -------------------------------------------------------------------------------------------------------------------
|   |                                                                                                                    
|B. | Consolidated Balance Sheets as of December 31, 2010 and
      2009.                                                
|   |                                                                                                                    
|C. | Consolidated Statements of Operations for the years ended
      of December 31, 2010 and 2009.                     
|   |                                                                                                                    
|D. | Consolidated Statements of Changes in Shareholders
      Equity for the years ended of December 31, 2010 and 2009.
|   |                                                                                                                    
|E. | Consolidated Statements of Cash Flows as of December 31,
      2010 and 2009.                                      
|   |                                                                                                                    
|F. | Notes to Consolidated Financial
  Statements.                                                                      

2.Financial Statement Schedules

Financial statement schedules not included herein have been
omitted because they are either not required, not applicable, or the information
is otherwise included herein.

(b) Exhibits.

EXHIBIT INDEX

|Exhibit No. | Description                                                                                                                                                        
|----------- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------
|2.1         | Share Exchange
      Agreement dated April 10, 2006 (incorporated by reference to the Form
      8-K/A filed on April 28, 2006).                                   
|3.1         | Articles of Incorporation
      (incorporated by reference to the Form SB-2 (File No. 333-90149) filed on
      November 16, 1999).                                
|3.2         | By-Laws
      (incorporated by reference to the Form SB-2 (File No. 333-91049) filed on
      November 16, 1999).                                                  
|3.3         | Amendment to the Articles of
      Incorporation (incorporated by reference to amendment No. 2 to Form SB-2
      (File No. 333- 135591) filed on August 28, 2006).
|3.4         | Amended and
      Restated By-Laws (incorporated by reference to the Form 8-K filed on March
      31, 2010).                                                      
|9.1         | Voting Trust Agreement
      (incorporated by reference to the Form 8-K/A filed on April 28, 2006).                                                                
|10.1        | Horst Zerbe
      Employment Agreement (incorporated by reference to the Form SB-2 (File No.
      333-135591) filed on July 3, 2006).                             
|10.2        | Ingrid Zerbe Employment Agreement
      (incorporated by reference to the Form SB-2 (File No. 333-135591) filed on
      July 3, 2006).                            
|10.3        | Registration
      Rights Agreement (incorporated by reference to the Form SB-2 (File No.
      333-135591) filed on July 3, 2006).                                
|10.4        | Principal's Registration Rights
      Agreement (incorporated by reference to the Form SB-2 (File No.
      333-135591) filed on July 3, 2006).                    
|10.5        | Investor
      Relations Consulting Agreement (incorporated by reference to the Form SB-2
      (File No. 333-135591) filed on July 3, 2006).                      
|10.6        | 2006 Stock Option Plan
      (incorporated by reference to the Form S-8 filed on November 21, 2006).                                                               
|10.7        | Form of
      Securities Purchase Agreement (incorporated by reference to the Form 8-K
      filed on May 23, 2007).                                               
|10.8        | Form of Registration Rights
      Agreement (incorporated by reference to the Form 8-K filed on May 23,
      2007).                                               
|10.9        | Form of Warrant
      (incorporated by reference to the Form 8-K filed on May 23, 2007).                                                                           
|10.10       | Form of Registration Rights
      Agreement (incorporated by reference to the Form 8-K filed on March 28,
      2008).                                             
|10.11       | Form of Warrant
      (incorporated by reference to the Form 8-K filed on March 28, 2008).                                                                         
|10.12       | Form of Lock up Agreement
      (incorporated by reference to the Form 8-K filed on March 28, 2008).                                                               
|10.13       | Form of Amended
      and Restated Warrant (incorporated by reference to the Form 8-K filed on
      August 4, 2008).                                              

11

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|10.14  | Employment Contract Paul A.
      Simmons (incorporated by reference to the Form 8-K filed on September 5,
      2008).                                                                                                                                   
|------ | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|10.15  | Brokers Warrant (incorporated by reference to
      the Form S-1 filed on March 24, 2009).                                                                                                                                                               
|10.16  | Code of Ethics (incorporated by
      reference to the Form S-1 filed on March 24, 2009).                                                                                                                                                                 
|10.17  | Amended and Restated 2006 Stock Option Plan,
      May 29, 2008 (incorporated by reference to the Form 10-K filed on March
      25, 2009).                                                                                                               
|10.18  | Agency Agreement, dated as of
      July 13, 2009, by and among the Company, Bolder Investment Partners Ltd.,
      Union Securities Ltd. and Paradigm Capital Inc. (incorporated by reference
      to the Form 8-K filed on July 14, 2009).             
|10.19  | Registration Rights Agreement, dated as of July
      13, 2009, by and among the Company, Paradigm Capital Inc., Bolder
      Investment Partners Ltd. and Union Securities Ltd. (incorporated by
      reference to the Form 8-K filed on July 14, 2009).
|10.20  | Form of Warrant (incorporated
      by reference to the Form 8-K filed on July 14, 2009).                                                                                                                                                                 
|10.21  | Form of Compensation Option (incorporated by
      reference to the Form 8-K filed on July 14, 2009).                                                                                                                                                     
|10.22  | Project Transfer Agreement
      (incorporated by reference to the Form 10-Q filed on May 14, 2010).                                                                                                                                                      
|10.23  | Co-development and Licensing Agreement
      (incorporated by reference to the Form 10-Q filed on May 14, 2010).                                                                                                                                          
|10.24  | Form of Amended and Restated
      Warrant (incorporated by reference to the Form 8-K filed on July 29,
      2010).                                                                                                                                      
|10.25  | Agency Agreement, dated as of August 27, 2010,
      between the Company and Bolder Investment Partners, Ltd. (incorporated by
      reference to the Form 8-K filed on August 30, 2010).                                                                 
|10.26  | Registration Rights Agreement,
      dated as of August 27, 2010, by and among the Company and the purchasers
      pursuant to the offering (incorporated by reference to the Form 8-K filed
      on August 30, 2010).                                  
|10.27  | Form of Warrant (incorporated by reference to
      the Form 8-K filed on August 30, 2010).                                                                                                                                                               
|10.28  | Form of Compensation Option
      (incorporated by reference to the Form 8-K filed on August 30, 2010).                                                                                                                                                   
|10.29  | Co-Development and Commercialization Agreement
      with RedHill Biopharma Ltd. (incorporated by reference to the Form 10- Q
      filed on November 9, 2010).                                                                                           
|10.30  | Amended and Restated 2006 Stock
      Option Plan (incorporated by reference to the Form S-8 filed on November
      15, 2010).                                                                                                                           
|10.31  | Form of Securities Purchase Agreement
      (incorporated by reference to the Form 8-K filed on June 3, 2011).                                                                                                                                            
|10.32  | Form of Warrant (incorporated
      by reference to the Form 8-K filed on June 3, 2011).                                                                                                                                                                  
|10.33  | Form of Registration Rights Agreement
      (incorporated by reference to the Form 8-K filed on June 3, 2011).                                                                                                                                            
|10.34* | License and Development
      Agreement between the Company and Azur Pharma International II Ltd.*                                                                                                                                                        
|14     | Code of Ethics (incorporated by reference to
      the Form S-1 filed on March 24, 2009)                                                                                                                                                                  
|16.1   | Letter on change in certifying
      accountant (incorporated by reference to the Form SB-2 (File No.
      333-135591) filed on July 3, 2006).                                                                                                           
|21.1   | Subsidiaries of the small business issuer
      (incorporated by reference to the Form SB-2 (File No. 333-135591) filed on
      July 3, 2006).                                                                                                           
|23.1   | Consent of RSM Richter
      Chamberland, LLP (incorporated by reference with original 10K filing on
      March 29, 2011                                                                                                                                 
|31.1** | Certification of Horst G. Zerbe, President and
      Chief Executive Officer, pursuant to Section 302 of the Sarbanes-Oxley Act
      of 2002.**                                                                                                          
|31.2** | Certification of Paul A.
      Simmons, Chief Financial Officer, pursuant to Section 302 of the
      Sarbanes-Oxley Act of 2002.**                                                                                                                       
|32.1** | Certification of Horst G. Zerbe, President and
      Chief Executive Officer, pursuant to 18 U.S.C. Section 1350.**                                                                                                                                       
|32.2** | Certification of Paul A.
      Simmons, Chief Financial Officer, pursuant to 18 U.S.C. Section 1350.**                                                                                                                                                    

* Filed herewith. Confidential treatment has been requested for
certain parts of this document, which are omitted and filed separately with the
SEC.

** Filed herewith.

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SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the
Exchange Act, the registrant has duly caused this Form 10-K/A Annual Report to
be signed on its behalf by the undersigned on September 20, 2011, thereunto duly
authorized.

| | INTELGENX TECHNOLOGIES CORP. |                                                   
| | ---------------------------- | --------------------------------------------------
| |                              |                                                   
| | By:                          | /s/Horst G. Zerbe                                 
| |                              | Horst G. Zerbe                                    
| |                              | President and Chief Executive Officer             
| |                              | (Principal Executive Officer)                     
| |                              |                                                   
| | By:                          | /s/Paul A. Simmons                                
| |                              | Paul A. Simmons                                   
| |                              | Chief Financial Officer                           
| |                              | (Principal Financial and Accounting
      Officer)

In accordance with the requirements of the Securities Exchange
Act of 1934, this Form 10-K/A Annual Report has been signed by the following
persons in the capacities and on the dates indicated.

|Signature                |  | Position                                              |  | Date              
|------------------------ |  | ----------------------------------------------------- |  | ------------------
|                         |  |                                                       |  |                   
|By: /s/ Horst G. Zerbe   |  | President, Chief Executive
      Officer and Director |  | September 20, 2011
|Horst G. Zerbe           |  |                                                       |  |                   
|                         |  |                                                       |  |                   
|By: /s/ Paul Simmons     |  | Chief Financial Officer                               |  | September 20, 2011
|Paul Simmons             |  |                                                       |  |                   
|                         |  |                                                       |  |                   
|By: /s/ Bernard Boudreau |  | Director                                              |  | September 20, 2011
|J. Bernard Boudreau      |  |                                                       |  |                   
|                         |  |                                                       |  |                   
|By: /s/ Ian Troup        |  | Director                                              |  | September 20, 2011
|John (Ian) Troup         |  |                                                       |  |                   
|                         |  |                                                       |  |                   
|By: /s/ Bernd Melchers   |  | Director                                              |  | September 20, 2011
|Bernd J. Melchers        |  |                                                       |  |                   
|                         |  |                                                       |  |                   
|By: /s/ John Marinucci   |  | Director                                              |  | September 20, 2011
|John Marinucci           |  |                                                       |  |                   
|                         |  |                                                       |  |                   
|By: /s/ Dr. Rajiv Khosla |  | Director                                              |  | September 20, 2011
|Dr. Rajiv Khosla         |  |                                                       |  |                   

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