Evidence Table MULTI.1. Trials with MULTI-ARM outcomes.

Trial/ Arm /Treatment Design, acne severity/

Dose, route, frequency

Trial/ Arm /Treatment Design, acne severity/

Dose, route, frequency

Trial # 53 n=177 Í Parallel;Mod/sev

Benzoyl peroxide 5% topical bid. 

Erythromycin 3% topical bid. 

Erythromycin 3% topical bid. 

Vehicle no dose information. 

Trial # 97 n=196 È Parallel;Mild/mod

Chlorhydroxyquinoline 0.25% topical (1 to 4 

times daily)

Chlorhydroxyquinoline 0.25% topical (1 to 4 

times daily)

Hydrocortisone 0.5% topical (1 to 4 

times daily)

Benzoyl peroxide 5.5% topical (1 to 4 

times daily)

Benzoyl peroxide 5.5% topical (1 to 4 

times daily)

Benzoyl peroxide 5.5% topical (1 to 4 

times daily)

Vehicle no dose information. 

Trial # 108 n=149 Parallel;Mild/mod/sev

Erythromycin 4% topical bid. 

Placebo (oral) no dose information. 

Placebo (oral) no dose information. 

Zinc (gel) 1.2% topical bid. 

Erythromycin 4% topical bid. 

Zinc acetate 1.2% topical bid. 

Placebo (oral) no dose information. 

Placebo (topical) no dose information. 

Tretracycline (oral) 250mg oral bid. 

Placebo (topical) no dose information. 

Trial # 109 n=42 Í Parallel;Mod

Benzoyl peroxide no dose information. 

Benzoyl peroxide no dose information. 

Benzoyl peroxide no dose information. 

Untreated no dose information. 

Trial # 119 n=28 È Parallel;Split face;

Adapalene 0.1% topical qd. 

Petrolatum no dose information. 

Tretinoin 0.025% topical qd. 

Tretinoin 0.01% topical qd. 

Tretinoin 0.05% topical qd. 

Tretinoin 0.1% topical qd. 

Tretinoin 0.025% topical qd. 

Trial # 120 n=27 È Parallel;Split face;

Adapalene 0.1% topical qd. 

Petrolatum no dose information. 

Tretinoin 0.025% topical qd. 

Tretinoin 0.1% topical qd. 

Tretinoin 0.1% topical qd. 

Tretinoin 0.1% topical qd. 

Trial # 132 n=36 È Parallel;Sev

Placebo no dose information. 

Spironolactone 100mg oral (can't say)

Spironolactone 150mg oral (can't say)

Spironolactone 50mg oral (can't say)

Spironolactone 200mg oral (can't say)

Trial # 149 n=250 Í Parallel;Mild/mod/sev

Benzoyl peroxide 10% topical bid. 

Benzoyl peroxide 5% topical bid. 

Tretinoin 0.05% topical qhs. 

benzoyl peroxide 5% topical qhs. 

Tretinoin 0.05% topical qhs. 

Benzoyl peroxide 10% topical qhs. 

Tretinoin 0.05% topical bid. 

Trial # 156 n=50 Í Parallel;Mod/sev

Cimetidine 1.6g oral (*)

Cimetidine 1.6g oral (*)

Spironolactone 100mg oral qd. 

Spironolactone 100mg oral qd. 

Trial # 177 n=107 È Parallel;

Benzoyl peroxide 10% topical bid. 

Hydrocortisone 1% topical bid. 

Benzoyl peroxide 10% topical bid. 

Potassium hydroxyquinol 0.5% topical bid. 

Benzoyl peroxide 10% topical bid. 

Potassium hydroxyquinol 0.5% topical bid. 

Vehicle no dose information. 

Trial # 214 n=393 È Parallel;Mod

Benzoyl peroxide 5% topical qhs. 

Benzoyl peroxide 5% topical qhs. 

Clindamycin 1% topical qhs. 

Clindamycin 1% topical qhs. 

Vehicle no dose information. 

MULTI.1 HEADINGS Page 1 of 2
Trial/ Arm /Treatment Design, acne severity/

Dose, route, frequency

Trial/ Arm /Treatment Design, acne severity/

Dose, route, frequency

Trial # 229 È Parallel;Split 

face;Mod/sev

n=88

Clindamycin hydrochlori 2% topical bid. 

Clindamycin phosphate 2% topical bid. 

Clindamycin phosphate 2% topical bid. 

Clindamycin hydrochlori 2% topical bid. 

E-solve no dose information. 

Ionax no dose information. 

Trial # 233 n=64 È Parallel;Mod/sev

Vehicle no dose information. 

Vitamin A palmitate 15000IU oral bid. 

Zinc sulfate 0.2g oral tid. 

Zinc sulfate 0.2g oral tid. 

Vitamin A palmitate 15000IU oral bid. 

Trial # 238 n=80 Í Parallel;Mod/sev

Erythromycin 2% topical bid. 

Tretinoin 0.05% topical qhs. 

Erythromycin base 2% topical bid. 

Tretinoin 0.05% topical qhs. 

Vehicle no dose information. 

Trial # 239 n=50 Í Parallel;Mod/sev

Aluminum Oxide no dose information. 

Sulfur no dose information. 

Polyester no dose information. 

Polyethylene no dose information. 

Polystyrene no dose information. 

Pumice no dose information. 

Trial # 266 n=82 È Parallel;Mod

Placebo 500mg oral tid. 

Shankhabhasma vah 500mg oral tid. 

Sookshama triphala 500mg oral tid. 

Sunder vati 500mg oral tid. 

Thiostanin 500mg oral tid. 

Trial # 287 n=79 Í Parallel;

Hydrocortisone 0.5% topical bid. 

Neomycin 0.5% topical bid. 

Resorcinol 1.5% topical bid. 

Sulphur 2.7% topical bid. 

Hydrocortisone F 0.5% topical bid. 

Resorcinol 1.5% topical bid. 

Neomycin 0.5% topical bid. 

Sulphur 2.7% topical bid. 

Vehicle no dose information. 

Trial # 288 n=188 Í Parallel;

Hydrocortisone 1% topical bid. 

Hydrocortisone 1 topical bid. 

Sulphur 4% topical bid. 

Neomycin 0.5% topical bid. 

Sulphur 4% topical bid. 

Sulphur 4% topical bid. 

Hydrocortisone 1% topical bid. 

Resorcinol 2% topical bid. 

Neomycin 0.5% topical bid. 

Neomycin 0.5% topical bid. 

Resorcinol 2% topical bid. 

Sulphur 4% topical bid. 

Vehicle no dose information. 

Trial # 302 n=20 Í Parallel;Split face;Mild

Tretinoin 0.05% topical qhs. 

Tretinoin 0.01% topical qhs. 

Tretinoin 0.025% topical qhs. 

Tretinoin 0.025% topical qhs. 

Trial # 340 n=91 È Parallel;Mod/sev

Erythromycin proprionate no dose information. 

Erythromycin stearate no dose information. 

Placebo no dose information. 

Tetracycline-novobiocin no dose information. 

Tetracycline phosphate no dose information. 

Tetracycline-citric acid no dose information. 

Triacetyl-oleandomycin no dose information. 

Trial # 349 n=68 Í Parallel;Mild/mod

Ibuprofen 600mg oral qid. 

Placebo no dose information. 

Tetracycline hydrochlorid 250mg oral qid. 

Ibuprofen 600mg oral qid. 

Placebo (ibuprofen) no dose information. 

Placebo no dose information. 

Placebo no dose information. 

Tetracycline hydrochlorid 250mg oral qid. 

Trial # 350 n=95 È Parallel;Split face;Sev

Grenz rays 200rads other (monthly)

Hexachlorophene no dose information. 

Grenz rays 200rads other (monthly)

Hexachlorophene no dose information. 

Placebo no dose information. 

Untreated no dose information. 

MULTI.1 HEADINGS Page 2 of 2