EX-4.1



 Exhibit 4.1 
  

 
 HORIZON PHARMA, INC. and HORIZON
PHARMA USA, INC. 
 8.750% SENIOR NOTES DUE 2024 
  

 
 INDENTURE 

Dated as of October 25, 2016 
  

 
 U.S. BANK
NATIONAL ASSOCIATION, 
 as Trustee 
  

 
  

 







 TABLE OF CONTENTS 
  

							
	 	 	 	  	Page	 
		
	ARTICLE 1	  			
	DEFINITIONS AND INCORPORATION	  			
	BY REFERENCE	  			
			
	 Section 1.01
	 	 Definitions
	  	 	1	 
	 Section 1.02
	 	 Other Definitions
	  	 	35	 
	 Section 1.03
	 	 Rules of Construction
	  	 	35	 
		
	ARTICLE 2	  			
	THE NOTES	  			
			
	 Section 2.01
	 	 Form and Dating
	  	 	36	 
	 Section 2.02
	 	 Execution and Authentication
	  	 	37	 
	 Section 2.03
	 	 Registrar and Paying Agent
	  	 	37	 
	 Section 2.04
	 	 Paying Agent to Hold Money in Trust
	  	 	38	 
	 Section 2.05
	 	 Holder Lists
	  	 	38	 
	 Section 2.06
	 	 Transfer and Exchange
	  	 	38	 
	 Section 2.07
	 	 Replacement Notes
	  	 	50	 
	 Section 2.08
	 	 Outstanding Notes
	  	 	50	 
	 Section 2.09
	 	 Treasury Notes
	  	 	51	 
	 Section 2.10
	 	 Temporary Notes
	  	 	51	 
	 Section 2.11
	 	 Cancellation
	  	 	51	 
	 Section 2.12
	 	 Defaulted Interest
	  	 	51	 
	 Section 2.13
	 	 CUSIP or ISIN Numbers
	  	 	51	 
		
	ARTICLE 3	  			
	REDEMPTION AND PREPAYMENT	  			
			
	 Section 3.01
	 	 Notices to Trustee
	  	 	52	 
	 Section 3.02
	 	 Selection of Notes to Be Redeemed or Purchased
	  	 	52	 
	 Section 3.03
	 	 Notice of Redemption
	  	 	52	 
	 Section 3.04
	 	 Effect of Notice of Redemption
	  	 	54	 
	 Section 3.05
	 	 Deposit of Redemption or Purchase Price
	  	 	54	 
	 Section 3.06
	 	 Notes Redeemed or Purchased in Part
	  	 	54	 
	 Section 3.07
	 	 Optional Redemption
	  	 	54	 
	 Section 3.08
	 	 Mandatory Redemption
	  	 	55	 
	 Section 3.09
	 	 Offer to Purchase
	  	 	55	 
	 Section 3.10
	 	 Redemption for Changes in Taxes
	  	 	57	 
		
	ARTICLE 4	  			
	COVENANTS	  			
			
	 Section 4.01
	 	 Payment of Notes
	  	 	58	 
	 Section 4.02
	 	 Maintenance of Office or Agency
	  	 	58	 
	 Section 4.03
	 	 Reports
	  	 	59	 
	 Section 4.04
	 	 Compliance Certificate
	  	 	60	 
	 Section 4.05
	 	 Reserved
	  	 	60	 
	 Section 4.06
	 	 Stay, Extension and Usury Laws
	  	 	60	 
	 Section 4.07
	 	 Restricted Payments
	  	 	60	 
	 Section 4.08
	 	 Dividend and Other Payment Restrictions Affecting Restricted Subsidiaries
	  	 	65	 
	 Section 4.09
	 	 Incurrence of Indebtedness and Issuance of Preferred Stock
	  	 	66	 


  
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	 	 	 	  	Page	 
			
	 Section 4.10
	 	 Asset Sales
	  	 	70	 
	 Section 4.11
	 	 Transactions with Affiliates
	  	 	72	 
	 Section 4.12
	 	 Liens
	  	 	74	 
	 Section 4.13
	 	 Corporate Existence
	  	 	75	 
	 Section 4.14
	 	 Offer to Repurchase Upon Change of Control
	  	 	75	 
	 Section 4.15
	 	 Reserved
	  	 	75	 
	 Section 4.16
	 	 Reserved
	  	 	75	 
	 Section 4.17
	 	 Reserved
	  	 	75	 
	 Section 4.18
	 	 Additional Note Guarantees
	  	 	75	 
	 Section 4.19
	 	 Designation of Restricted and Unrestricted Subsidiaries
	  	 	76	 
	 Section 4.20
	 	 Suspension of Covenants When Notes Rated Investment Grade
	  	 	77	 
	 Section 4.21
	 	 Additional Amounts
	  	 	78	 
		
	ARTICLE 5	  			
	SUCCESSORS	  			
			
	 Section 5.01
	 	 Merger, Consolidation or Sale of Assets
	  	 	80	 
	 Section 5.02
	 	 Successor Corporation Substituted
	  	 	82	 
		
	ARTICLE 6	  			
	DEFAULTS AND REMEDIES	  			
			
	 Section 6.01
	 	 Events of Default
	  	 	82	 
	 Section 6.02
	 	 Acceleration
	  	 	83	 
	 Section 6.03
	 	 Other Remedies
	  	 	84	 
	 Section 6.04
	 	 Waiver of Past Defaults
	  	 	84	 
	 Section 6.05
	 	 Control by Majority
	  	 	85	 
	 Section 6.06
	 	 Limitation on Suits
	  	 	85	 
	 Section 6.07
	 	 Rights of Holders of Notes to Receive Payment
	  	 	85	 
	 Section 6.08
	 	 Collection Suit by Trustee
	  	 	85	 
	 Section 6.09
	 	 Trustee May File Proofs of Claim
	  	 	85	 
	 Section 6.10
	 	 Priorities
	  	 	86	 
	 Section 6.11
	 	 Undertaking for Costs
	  	 	86	 
		
	ARTICLE 7	  			
	TRUSTEE	  			
			
	 Section 7.01
	 	 Duties of Trustee
	  	 	86	 
	 Section 7.02
	 	 Rights of Trustee
	  	 	87	 
	 Section 7.03
	 	 Individual Rights of Trustee
	  	 	88	 
	 Section 7.04
	 	 Trustee’s Disclaimer
	  	 	89	 
	 Section 7.05
	 	 Notice of Defaults
	  	 	89	 
	 Section 7.06
	 	 Compensation and Indemnity
	  	 	89	 
	 Section 7.07
	 	 Replacement of Trustee
	  	 	90	 
	 Section 7.08
	 	 Successor Trustee by Merger, etc.
	  	 	91	 
	 Section 7.09
	 	 Eligibility; Disqualification
	  	 	91	 
		
	ARTICLE 8	  			
	LEGAL DEFEASANCE AND COVENANT DEFEASANCE	  			
			
	 Section 8.01
	 	 Option to Effect Legal Defeasance or Covenant Defeasance
	  	 	91	 
	 Section 8.02
	 	 Legal Defeasance and Discharge
	  	 	91	 
	 Section 8.03
	 	 Covenant Defeasance
	  	 	92	 
	 Section 8.04
	 	 Conditions to Legal or Covenant Defeasance
	  	 	92	 
	 Section 8.05
	 	 Deposited Money and Government Securities to be Held in Trust; Other Miscellaneous
Provisions
	  	 	93	 


  
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	 	 	 	  	Page	 
			
	 Section 8.06
	 	 Repayment to Issuers
	  	 	94	 
	 Section 8.07
	 	 Reinstatement
	  	 	94	 
		
	ARTICLE 9	  			
	AMENDMENT, SUPPLEMENT AND WAIVER	  			
			
	 Section 9.01
	 	 Without Consent of Holders of Notes
	  	 	94	 
	 Section 9.02
	 	 With Consent of Holders of Notes
	  	 	95	 
	 Section 9.03
	 	 Revocation and Effect of Consents
	  	 	97	 
	 Section 9.04
	 	 Notation on or Exchange of Notes
	  	 	97	 
	 Section 9.05
	 	 Trustee to Sign Amendments, etc.
	  	 	97	 
		
	ARTICLE 10	  			
	NOTE GUARANTEES	  			
			
	 Section 10.01
	 	 Guarantee
	  	 	98	 
	 Section 10.02
	 	 Limitation on Guarantor Liability
	  	 	99	 
	 Section 10.03
	 	 Issuance and Delivery of Note Guarantee
	  	 	99	 
	 Section 10.04
	 	 Guarantors May Consolidate, etc., on Certain Terms
	  	 	99	 
	 Section 10.05
	 	 Releases
	  	 	100	 
		
	ARTICLE 11	  			
	SATISFACTION AND DISCHARGE	  			
			
	 Section 11.01
	 	 Satisfaction and Discharge
	  	 	101	 
	 Section 11.02
	 	 Application of Trust Money
	  	 	101	 
		
	ARTICLE 12	  			
	MISCELLANEOUS	  			
			
	 Section 12.01
	 	 Notices
	  	 	102	 
	 Section 12.02
	 	 Communication by Holders of Notes with Other Holders of Notes
	  	 	103	 
	 Section 12.03
	 	 Certificate and Opinion as to Conditions Precedent
	  	 	103	 
	 Section 12.04
	 	 Statements Required in Certificate or Opinion
	  	 	103	 
	 Section 12.05
	 	 Form of Documents Delivered to Trustee
	  	 	104	 
	 Section 12.06
	 	 Rules by Trustee and Agents
	  	 	104	 
	 Section 12.07
	 	 No Personal Liability of Directors, Officers, Employees and Stockholders
	  	 	104	 
	 Section 12.08
	 	 Governing Law; Waiver of Jury Trial
	  	 	104	 
	 Section 12.09
	 	 No Adverse Interpretation of Other Agreements
	  	 	105	 
	 Section 12.10
	 	 Successors
	  	 	105	 
	 Section 12.11
	 	 Severability
	  	 	105	 
	 Section 12.12
	 	 Counterpart Originals
	  	 	105	 
	 Section 12.13
	 	 Table of Contents, Headings, etc.
	  	 	105	 
	 Section 12.14
	 	 U.S.A. Patriot Act
	  	 	105	 
	 Section 12.15
	 	 Force Majeure
	  	 	105	 


  
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 EXHIBITS 
  

			
	Exhibit A	    	FORM OF NOTE
	Exhibit B	    	FORM OF CERTIFICATE OF TRANSFER
	Exhibit C	    	FORM OF CERTIFICATE OF EXCHANGE
	Exhibit D	    	FORM OF CERTIFICATE OF ACQUIRING INSTITUTIONAL ACCREDITED INVESTOR
	Exhibit E	    	FORM OF SUPPLEMENTAL INDENTURE


  
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 INDENTURE dated as of October 25 2016 among HORIZON PHARMA, INC., a Delaware corporation,
HORIZON PHARMA USA, INC., a Delaware corporation, the Guarantors from time to time party hereto and U.S. BANK NATIONAL ASSOCIATION, a national banking association, as trustee (the “Trustee”). 

The Issuers (as defined herein), the Guarantors and the Trustee agree as follows for the benefit of each other and for the equal and ratable
benefit of the Holders (as defined herein) of the 8.750% Senior Notes due 2024 (the “Notes”): 
 ARTICLE 1 

DEFINITIONS AND INCORPORATION 
 BY
REFERENCE 
 Section 1.01 Definitions. 

“2022 Notes” means Horizon Limited’s 2.50% Exchangeable Senior Notes due March 15, 2022. 

“2023 Notes” means the Company’s 6.625% Senior Notes due 2023. 

“144A Global Note” means a Global Note substantially in the form of Exhibit A hereto bearing the Global Note Legend and the
Private Placement Legend and deposited with or on behalf of, and registered in the name of, the Depositary or its nominee that will be issued in a denomination equal to the outstanding principal amount of the Notes sold in reliance on Rule 144A.

 “Acquired Indebtedness” means Indebtedness (1) of a Person or any of its Subsidiaries existing at the time such
Person becomes a Restricted Subsidiary, (2) assumed in connection with the acquisition of assets from such Person, in each case whether or not Incurred by such Person in connection with such Person becoming a Restricted Subsidiary of the Parent or
such acquisition or (3) of a Person at the time such Person merges or amalgamates with or into or consolidates or otherwise combines with the Parent or any Restricted Subsidiary. Acquired Indebtedness shall be deemed to have been Incurred, with
respect to clause (1) of the preceding sentence, on the date such Person becomes a Restricted Subsidiary and, with respect to clause (2) of the preceding sentence, on the date of consummation of such acquisition of assets and, with respect
to clause (3) of the preceding sentence, on the date of the relevant merger, amalgamation, consolidation or other combination.

“Acquisition ” means the transactions contemplated by the Merger Agreement.

“Affiliate” of any specified Person means any other Person directly or indirectly controlling or controlled by or under
direct or indirect common control with such specified Person. For purposes of this definition, “control,” as used with respect to any Person, means the possession, directly or indirectly, of the power to direct or cause the direction of
the management or policies of such Person, whether through the ownership of voting securities, by agreement or otherwise. For purposes of this definition, the terms “controlling,” “controlled by” and “under
common control with” have correlative meanings. 
 “Agent” means any Registrar, co-registrar, Paying Agent or
additional paying agent. 
 “Andromeda” means Andromeda Biotech Ltd. 

“Andromeda Release Agreement” means that certain Completion of Phase III Clinical Trial, Option and Mutual Release Agreement
(as amended, supplemented or modified from time to time) by and among Hyperion, Hyperion Therapeutics Israel Holding Corp Ltd, Clal Biotechnology Industries Ltd., Yeda Research and Development Company Ltd. and Andromeda.







 “Andromeda Transactions” means the transactions contemplated by the Andromeda
Release Agreement, including potential sale of the Equity Interests in Andromeda pursuant to an option granted thereunder.

“Applicable Guarantee Limitations” means, with respect to any Note Guarantee of a Guarantor or other Person, limitations
thereon as necessary to prevent the relevant Note Guarantee from constituting a fraudulent conveyance, fraudulent transfer or unlawful financial assistance under applicable law, or otherwise to reflect limitations under applicable law, including in
the case of any Foreign Subsidiary, limitations to avoid any breach of corporate benefit, financial assistance, fraudulent preference, related or connected person transaction, thin capitalisation rules or the laws or regulations (or analogous
restrictions) of any applicable jurisdiction or any similar restrictions that may limit the ability of any Foreign Subsidiary to provide a guarantee or may require that the guarantee be limited by an amount or scope or otherwise and to avoid any
material risk to the officers or directors of the applicable Foreign Subsidiary of contravention of their fiduciary duties or any legal prohibition and risk to the officers or directors of the applicable Foreign Subsidiary of civil or criminal
liability. 
 “Applicable Premium” means, with respect to any Note on any redemption date, the greater of: 

(1) 1.0% of the principal amount of the Note; or 

(2) the excess of: (a) the present value at such redemption date of (i) the redemption price of the Note at November 1,
2019 (such redemption price being set forth in the table appearing below in Section 3.07) plus (ii) all required interest payments due on the Note from such redemption date through November 1, 2019 (excluding accrued but unpaid interest to the
redemption date), computed using a discount rate equal to the Treasury Rate as of such redemption date (or in the case of a satisfaction and discharge, as of the date that redemption funds are deposited with the Trustee) plus 50 basis points; over
(b) the principal amount of the Note. 
 “Applicable Procedures” means, with respect to any transfer or exchange of or for
beneficial interests in any Global Note, the rules and procedures of the Depositary, Euroclear and Clearstream that apply to such transfer or exchange. 

“Asset Sale” means any Disposition (or series of related Dispositions) by the Parent or any Restricted Subsidiary, of: 

(1) any shares of Capital Stock of a Restricted Subsidiary (other than directors’ qualifying shares or shares required by
applicable law to be held by a Person other than the Parent or a Restricted Subsidiary); 
 (2) all or substantially all the
assets of any division or line of business of the Parent or any Restricted Subsidiary; or 
 (3) any other assets of the
Parent or any Restricted Subsidiary outside of the ordinary course of business of the Parent or such Restricted Subsidiary, 

  
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 other than, in the case of clauses (1), (2) and (3) above: 

 

	 	(a)	a Disposition by a Restricted Subsidiary to the Parent or by the Parent or a Restricted Subsidiary to a Restricted Subsidiary and Preferred Stock or Disqualified Stock of Restricted Subsidiaries issued in compliance
with Section 4.09; 

  

	 	(b)	for purposes of Section 4.10 only, a disposition that constitutes a Restricted Payment (or would constitute a Restricted Payment but for the exclusions from the definition thereof) that is not prohibited by Section 4.07
or that constitutes a Permitted Investment; 

  

	 	(c)	a Disposition of all or substantially all the assets of the Parent and its Restricted Subsidiaries taken as a whole in accordance with Section 5.01 or any disposition that constitutes a Change of Control pursuant to
this Indenture; 

  

	 	(d)	a Disposition of assets with a Fair Market Value of less than or equal to $15.0 million in any single transaction or series of related transactions; 


 

	 	(e)	sales or dispositions of damaged, expired, short-dated, worn-out or obsolete equipment or assets in the ordinary course of business that, in the Parent’s reasonable judgment, are no longer either used or useful in
the business of the Parent or its Subsidiaries; 

  

	 	(f)	the license or sublicense of intellectual property or other general intangibles and licenses, leases or subleases of other property which do not materially interfere with the business of the Parent and its Restricted
Subsidiaries, taken as a whole, determined in good faith by the Parent; 

  

	 	(g)	to the extent allowable under Section 1031 of the Code, any exchange of like property (excluding any boot thereon) for use in a Permitted Business; 


 

	 	(h)	any issuance or sale of Capital Stock in, or Indebtedness or other securities of, an Unrestricted Subsidiary; 

  

	 	(i)	foreclosures, condemnation, expropriation or any similar action on assets of the Parent or any of the Restricted Subsidiaries; 

  

	 	(j)	the sale or discount of inventory, accounts receivable or notes receivable in the ordinary course of business or the conversion of accounts receivable to notes receivable; 


 

	 	(k)	any surrender or waiver of contract rights or the settlement, release or surrender of contract rights or other litigation claims in the ordinary course of business; 


 

	 	(l)	the settlement, termination or unwinding of any Hedging Obligation or Hedge Agreement; 

  

	 	(m)	sales, transfers and other dispositions of Investments in joint ventures made in the ordinary course of business or to the extent required by, or made pursuant to, customary buy/sell arrangements between the joint
venture parties set forth in joint venture arrangements and similar binding arrangements; 

  

	 	(n)	the abandonment of intellectual property rights in the ordinary course of business, which in the reasonable good faith determination of the Parent are not material to the conduct of the business of the Parent and the
Restricted Subsidiaries taken as a whole; 


  
 3 









	 	(o)	the settlement or early termination of any Permitted Equity Derivative; 

  

	 	(p)	a Disposition of cash, Cash Equivalents or marketable securities; 

  

	 	(q)	a Disposition in connection with a co-development or collaboration agreement; 

  

	 	(r)	the creation of a Lien (but not the sale or other disposition of the property subject to such Lien); 

  

	 	(s)	Dispositions of Capital Stock in any Subsidiary prior to the time such Subsidiary becomes a Wholly-Owned Subsidiary, in each case pursuant to any stock appreciation rights, plans, equity incentive or achievement plans
or any similar plans or the exercise of warrants, options or other securities convertible into or exchangeable for the Capital Stock of such Subsidiary, so long as such rights, plans, warrants, options or other securities were not entered into or
issued in connection with or in contemplation of such person becoming a Subsidiary; 

  

	 	(t)	any sale of Securitization Program Assets in connection with a Qualified Securitization Transaction; 

  

	 	(u)	any sale and leaseback transaction provided that the Attributable Debt in respect of such Transaction would be permitted to be incurred under Section 4.09 and Section 4.12 if such Attributable Debt were treated as
secured Indebtedness; and 

  

	 	(v)	the Andromeda Transactions.

 “Asset Sale Offer” has the meaning assigned to
that term in Section 4.10.
 “Attributable Debt” in respect of a sale and leaseback transaction means, at the time of
determination, the present value of the obligation of the lessee for net rental payments during the remaining term of the lease included in such sale and leaseback transaction including any period for which such lease has been extended or may, at
the option of the lessor, be extended. Such present value shall be calculated using a discount rate equal to the rate of interest implicit in such transaction, determined in accordance with GAAP. 

“Bankruptcy Custodian” means any receiver, interim receiver, receiver and manager, trustee, assignee, liquidator, examiner,
custodian or similar official under any Bankruptcy Law. 
 “Bankruptcy Law” means Title 11, U.S. Code or any similar
federal or state law for the relief of debtors or similar foreign law (including, without limitation, laws of Ireland relating to bankruptcy, insolvency, receivership”, winding up, liquidation, examinership, reorganization or relief of
debtors). 
 “Beneficial Owner” has the meaning assigned to such term in Rule 13d-3 and Rule 13d-5 under the Exchange Act,
except that in calculating the beneficial ownership of any particular “person” (as that term is used in Section 13(d)(3) of the Exchange Act), such “person” will be deemed to have beneficial ownership of all securities that such
“person” has the right to acquire by conversion or exercise of other securities, whether such right is currently exercisable or is exercisable only after the passage of time. The terms “Beneficially Owns” and
“Beneficially Owned” have a corresponding meaning. 

  
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 “Board of Directors” means: 

(1) with respect to a corporation, the board of directors of the corporation or any committee thereof duly authorized to act on
behalf of such board; 
 (2) with respect to a partnership, the Board of Directors of the general partner of the partnership;

 (3) with respect to a limited liability company managed by the member or members, the managing member or members or any
controlling committee of managing members thereof; 
 (4) with respect to a limited liability company managed by a manager or
managers, the manager or managers and any controlling committee of managers; and 
 (5) with respect to any other Person, the
board or committee of such Person serving a similar function. 
 “Business Day” means any day other than a Legal Holiday.

 “Capital Lease Obligation” means, with respect to any Person, the obligations of such Person to pay rent or other
amounts under any lease of (or other arrangement conveying the right to use) real or personal property, or a combination thereof, which obligations are required to be classified and accounted for as capital leases on a balance sheet of such Person
under GAAP; and, for the purposes of this Indenture, the amount of such obligations at any time shall be the capitalized amount thereof at such time determined in accordance with GAAP.

“Capital Stock” of any Person means any and all shares, interests, participations, rights in or other equivalents (however
designated) of such Person’s capital stock, partnership interests (whether general or limited), limited liability company interests and any other interest or participation that confers on a Person the right to receive a share of the profits and
losses of, or distributions of assets of, the issuing Person, including any Preferred Stock. 
 “Cash Equivalents” means:

 (1) (a) United States dollars, Euro or any national currency of any member state of the European Union; (b) with
respect to Parent or any Restricted Subsidiary, the national currency of the jurisdiction in which such Person is organized or domiciled, and (c) any other foreign currency held by the Parent and the Restricted Subsidiaries in the ordinary
course of business; 
 (2) direct obligations of, or obligations the principal of and interest on which are unconditionally
guaranteed by, the United States of America or a member state of the European Union (or by any agency thereof to the extent such obligations are backed by the full faith and credit of the United States of America or such member state), in each case
maturing within eighteen months from the date of acquisition thereof; 
 (3) investments in commercial paper maturing within
270 days from the date of acquisition thereof and having, at such date of acquisition, the highest credit rating obtainable from S&P or from Moody’s; 

(4) certificates of deposit, time deposits and eurodollar time deposits with maturities of one year or less from the date of
acquisition, demand deposits, bankers’ acceptances with 

  
 5 








 
maturities not exceeding one year and overnight bank deposits, in each case with any domestic or foreign commercial bank having capital and surplus of not less than $500.0 million in the case of
U.S. banks and $250.0 million (or the foreign currency equivalent as of the date of determination) in the case of non-U.S. banks; 

(5) fully collateralized repurchase agreements with a term of not more than thirty (30) days for securities described in
clauses (2) and (4) above and entered into with a financial institution satisfying the criteria described in clause (4) above; 

(6) marketable short-term money market and similar liquid funds having a rating of at least P-2 or A-2 from either Moody’s
or S&P, respectively (or, if at any time neither Moody’s nor S&P shall be rating such obligations, an equivalent rating from another nationally recognized statistical rating agency); 

(7) Investments with average maturities of 24 months or less from the date of acquisition in money market funds and similar
liquid funds rated AA- (or the equivalent thereof) or better by S&P or Aa3 (or the equivalent thereof) or better by Moody’s (or, if at any time neither Moody’s nor S&P shall be rating such obligations, an equivalent rating from
another nationally recognized statistical rating agency); 
 (8) securities issued or fully guaranteed by any state,
commonwealth or territory of the United States of America or by any political subdivision (including any municipality) or taxing authority of any such state, commonwealth or territory, the securities of which state, commonwealth, territory,
political subdivision or taxing authority (as the case may be) are rated at least “A” (or A-1, SP1 or other then equivalent grade) by S&P or at least “A1” (or “Prime-1” or MIG-1 or other then equivalent grade) by
Moody’s as of the date of acquisition and, in each case, with a maturity of not more than two years from the date of acquisition thereof; 

(9) investment funds investing substantially all of their assets in securities of the types described in clauses
(1) through (8) above; and 
 (10) in the case of any the Parent or Foreign Subsidiary, other short-term
investments that are analogous to the foregoing, are of comparable credit quality and are customarily used by companies in the jurisdiction of the Parent or such Foreign Subsidiary for cash management purposes.

Notwithstanding the foregoing, Cash Equivalents shall include amounts denominated in currencies other than those set forth in
clause (1); provided that such amounts are converted into any currency listed in clause (1) as promptly as practicable and in any event within ten Business Days following the receipt of such amounts. 

“Change of Control” means the occurrence of any of the following: 

(1) any “person” or “group” (as such terms are used in Sections 13(d) and 14(d) of the Exchange Act) other
than the Parent or its Wholly-Owned Subsidiaries or its or their employee benefit plans becomes the “Beneficial Owner” (as defined in Rules 13d-3 and 13d-5 under the Exchange Act), directly or indirectly, of more than 50% of the total
outstanding Voting Stock of the Parent or any Issuer, as disclosed in a Schedule TO or any schedule, form or other report under the Exchange Act (other than Form 13F); 

  
 6 








 (2) the sale, lease, transfer, conveyance or other disposition (other than by way
of merger, amalgamation, consolidation or other business combination transaction), in one or a series of related transactions, of all or substantially all of the assets of the Parent and its Restricted Subsidiaries taken as a whole to a Person,
other than a Restricted Subsidiary; 
 (3) the Parent or an Issuer is liquidated or dissolved or adopts a plan of liquidation
or dissolution other than in a transaction which complies with Section 5.01; or 
 (4) any Issuer ceases to be either a
direct or indirect Wholly-Owned Subsidiary of the Parent. 
 Notwithstanding the foregoing, a transaction will not be deemed to constitute a
Change of Control if (1) the Parent, the Company or the Co-Issuer becomes a direct or indirect Wholly-Owned Subsidiary of a holding company and (2)(A) the direct or indirect holders of the Voting Stock of such holding company immediately
following that transaction are substantially the same as the holders of the Parent’s or applicable Issuer’s Voting Stock immediately prior to that transaction or (B) immediately following that transaction no Person (other than a holding
company satisfying the requirements of this sentence) is the Beneficial Owner, directly or indirectly, of more than 50% of the Voting Stock of such holding company.

“Change of Control Offer” has the meaning assigned to that term in Section 4.14.

“Clearstream” means Clearstream Banking, S.A. 

“Co-Issuer” means Horizon Pharma USA, Inc., a Delaware corporation. 

“Code” means the U.S. Internal Revenue Code of 1986, as amended. 

“Company” means Horizon Pharma, Inc., a Delaware corporation. 

“Commodity Price Protection Agreement” means any forward contract, commodity swap, commodity option or other similar
financial agreement or arrangement relating to, or the value of which is dependent upon, fluctuations in commodity prices. 

“Consolidated Adjusted EBITDA” means, with respect to any Person for any period, the Consolidated Net Income of such Person
and the Restricted Subsidiaries for such period plus, without duplication and to the extent deducted in determining Consolidated Net Income for such period, the sum of: 

(1) expense and provision for taxes, paid or accrued, 

(2) consolidated interest expense and charges and deferred financing fees, losses on hedging obligations or other derivative
instruments entered into for the purpose of hedging interest rate risk, net of gains on such hedging obligations, and costs of surety bonds in connection with financing activities, 

(3) Consolidated Depreciation and Amortization Expense, 

(4) (a) non-cash charges recorded in respect of purchase accounting and non-cash exchange, translation or performance losses
relating to any foreign currency hedging transactions or currency fluctuations, and (b) non-cash expenses, charges or losses reducing Consolidated Net Income (and not otherwise excluded thereunder) during such period in connection with royalty
payments or expected future royalty payments, 

  
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 (5) any other non-cash items except to the extent representing an accrual for
future cash outlays, including pursuant to any management equity plan or stock plan or pursuant to SFAS 158 (codified under ASC 715), 

(6) Milestone Payments, Upfront Payments and Deferred Acquisition Consideration (other than ongoing royalty payments) paid or
accrued during such period, 
 (7) expenses with respect to casualty events, 

(8) the amount of net cost savings and synergies projected by Parent in connection with any acquisition (including the Merger)
or otherwise projected by the Parent in good faith to be realized as a result of specified actions taken or expected to be taken (which cost savings or synergies shall be subject only to an Officer’s Certificate of the Parent and shall be
calculated on a pro forma basis as though such cost savings and synergies had been realized on the first day of the relevant period), net of the amount of actual benefits realized during such period from such actions, provided that
(A) in connection with any acquisition, such cost savings or synergies are factually supportable in the good faith judgment of Parent, (B) the Parent believes in good faith that such cost savings or synergies are reasonably anticipated to
be realizable within 18 months after the closing date of such acquisition, and (C) no cost savings shall be added pursuant to this clause (8) to the extent duplicative of any expenses or charges relating to such cost savings that are
excluded from the calculation of Consolidated Net Income with respect to such period (“Pro Forma Cost Savings”), 

(9) to the extent actually reimbursed, expenses incurred to the extent covered by indemnification provisions in any agreement
in connection with any acquisition permitted under this Indenture, 
 (10) cash charges and legal expenses in connection with
litigation relating to Products, in an aggregate amount for such Four Quarter Period not to exceed $5,000,000, and 
 (11)
all reserves taken during such period on account of contingent cash payments that may be required in future periods, 
 minus, to the extent included
in Consolidated Net Income for such period, the sum of (x) any unusual, infrequent or extraordinary income or gains, (y) any other non-cash income (except to the extent representing an accrual for future cash income) and (z) any cash
payments made during such period in respect of items described in clause (4)(b) above subsequent to the applicable four quarter period in which the relevant non-cash expenses or losses were incurred together with any cash payments made during
such period in respect of ongoing royalty payments, all calculated for the Parent and the Restricted Subsidiaries in accordance with GAAP (to the extent applicable) on a consolidated basis; provided that, to the extent included in
Consolidated Net Income, (A) currency translation gains and losses related to currency remeasurements of Indebtedness shall be excluded in determining Consolidated Adjusted EBITDA (including the net loss or gain resulting from swap agreements
for currency exchange risk) and (B) any adjustments resulting from the application of SFAS 133 (codified under ASC 815) shall be excluded in determining Consolidated Adjusted EBITDA.

“Consolidated Depreciation and Amortization Expense” means with respect to any Person for any period, the total amount of
depreciation and amortization expense, including any amortization of deferred 

  
 8 








 
financing fees, accretion of royalty liabilities, amortization in relation to terminated Hedging Obligations and amortization of intangibles, including, but not limited to, goodwill, of such
Person and the Restricted Subsidiaries for such period on a consolidated basis and otherwise determined in accordance with GAAP.

“Consolidated Interest Expense” means, with respect to any period, the sum, without duplication, of: 

(1) the interest expense, whether or not paid in cash, of the Parent and the Restricted Subsidiaries calculated on a
consolidated basis for such period in accordance with GAAP, including, without limitation, interest expense under Capital Lease Obligations that is treated as interest in accordance with GAAP, imputed interest with respect to Attributable Debt and
net payments, if any, pursuant to interest rate Hedging Obligations, but excluding any (i) non-cash interest expense attributable to the movement in mark-to-market valuation of Hedging Obligations or other derivative instruments pursuant to
SFAS No. 133 (codified under ASC 815), (ii) non-cash interest expense attributable to the amortization of gains or losses resulting from the termination of Hedging Obligations prior to or reasonably contemporaneously with the Issue Date,
(iii) amortization of deferred financing fees, (iv) expensing of commitment, bridge or other financing fees, and (v) interest expense arising out of the amortization of debt discount under Accounting Standards Codification 470-20;
less 
 (2) interest income of the Parent and the Restricted Subsidiaries for such period (including income pursuant
to any Hedging Obligations).
 “Consolidated Net Income” means, of any Person for any period, the consolidated net income
(or loss) of such Person and the Restricted Subsidiaries for such period, determined on a consolidated basis in accordance with GAAP; provided that, in calculating Consolidated Net Income of the Parent and the Restricted Subsidiaries for any
period, there shall be excluded: 
 (1) the income (or deficit) of any Person (other than a Restricted Subsidiary of the
Parent); provided that any such income so excluded may be included in such period or any later period to the extent that any such income is actually received by the Parent or such Restricted Subsidiary in the form of dividends or similar
distributions during the applicable period; 
 (2) solely for the purpose of determining the amount available for Restricted
Payments under clause (iii)(A) of Section 4.07(a), the undistributed earnings of any Restricted Subsidiary of the Parent (other than a Guarantor) to the extent that the declaration or payment of dividends or similar distributions by such Restricted
Subsidiary is not at the time permitted by the terms of any agreement, instrument, contract, charter, organizational or governing document or other undertaking applicable to such Person, to which such Person is a party or by which any of its
property is bound or any law, treaty, rule, regulation or determination of an arbitrator or a court of competent jurisdiction or other Governmental Authority, in each case, applicable or binding upon such Person or any of its Property or to which
such Person or any of its property is subject; 
 (3) any fees and expenses incurred during such period, or any amortization
thereof for such period, in connection with the consummation of any acquisition, investment, asset disposition, issuance or repayment of debt, issuance of equity securities, refinancing transaction or amendment or other modification of any debt
instrument (in each case, including any such transaction consummated prior to April 29, 2015, and any such transaction undertaken but not completed) and any charges or non-recurring costs incurred during such period as a result of any such
transaction; 

  
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 (4) any amortization of debt discount under Accounting Standards Codification
470-20; 
 (5) any income (loss) for such period attributable to the early extinguishment of Indebtedness, together with any
related provision for taxes on any such income; 
 (6) non-cash amounts included in Consolidated Interest Expense; 

(7) non-cash compensation expense incurred with any issuance of Equity Interests to any director, employee or consultant of
such Person or any Restricted Subsidiary; 
 (8) any gain or loss realized as a result of the cumulative effect of a change
in accounting principles; 
 (9) the effects of discontinued operations (including non-recurring income, gains or losses) and
any non-cash gains or losses from asset dispositions; 
 (10) any non-cash foreign translation gains and losses; and 

(11) any unusual, infrequent or extraordinary loss or charge and any restructuring charges or reserves, including write-downs
and write-offs, any one-time costs incurred in connection with the Transactions, Permitted Investments and Dispositions, costs related to the closure, consolidation and integration of facilities, information technology infrastructure and legal
entities, and severance and retention bonuses, any charges to establish accruals and reserves or to make payments associated with the reassessment or realignment of the business and operations of the Parent and its Subsidiaries (including, without
limitation, the sale or closing of facilities, severance, stay bonuses and curtailments or modifications to pension and post-retirement employee benefit plans, asset impairments or asset disposals (including leased facilities), charges for purchase
and lease commitments, start-up costs for new facilities, reserves for excess, obsolete or unbalanced inventories, relocation costs which are not otherwise capitalized, and any related promotional costs of exiting products or product lines.

There shall be excluded from Consolidated Net Income for any period (i) any gains or losses resulting from any
reappraisal, revaluation or write-up or write-down of assets or liabilities (including any gains and losses attributable to movement in the mark-to-market valuation of (a) any Permitted Convertible Indebtedness, (b) any Permitted
Convertible Indebtedness Call Transaction and (c) Deferred Acquisition Consideration), (ii) any non-cash charges recorded in respect of intangible assets, including goodwill and (iii) the effect of any purchase accounting adjustments
in respect of any acquisition consummated prior to April 29, 2015, the Transactions and any acquisition or Investment permitted under this Indenture, and the amortization or write-off of any amounts in respect thereof. 

“Consolidated Senior Secured Debt Ratio” means, as of any date of determination, the ratio of (i) Consolidated Total
Indebtedness that is secured by a Lien on the Property of the Parent, any of the Issuers or any other Guarantor as of such date minus the aggregate amount (not to exceed $50.0 million) of unrestricted cash and Cash Equivalents, whether or not held
in pledged accounts, of the Parent and the Restricted Subsidiaries on a consolidated basis to (ii) Consolidated Adjusted EBITDA of the Parent for the most recent four consecutive fiscal quarters ending prior to the date of determination for
which internal financial statement are available ending, in each case with such pro forma adjustments as reasonably determined by the Parent to be appropriate and consistent with the pro forma adjustment provisions set forth in the definition of
Fixed Charge Coverage Ratio.

  
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 “Consolidated Total Indebtedness” means, as at any date of determination, the
sum, without duplication, of (1) the aggregate amount of all outstanding Indebtedness of the Parent and the Restricted Subsidiaries on a consolidated basis consisting of Indebtedness for borrowed money, Indebtedness in respect of Capital Lease
Obligations and Purchase Money Indebtedness and Indebtedness evidenced by notes, debentures, bonds and similar instruments (other than Indebtedness with respect to Treasury Management Arrangements and intercompany Indebtedness), (2) the
principal amount of any obligations of any Person (other than the Parent or any Restricted Subsidiary) of the type described in the foregoing clause (1) that are Guaranteed by the Parent or any Restricted Subsidiary (whether or not reflected on
a consolidated balance sheet of the Parent) and (3) the aggregate amount of all outstanding Disqualified Stock of the Parent and all Preferred Stock of the Restricted Subsidiaries (other than intercompany Indebtedness) on a consolidated basis,
with the amount of such Disqualified Stock and Preferred Stock equal to the greater of their respective voluntary or involuntary liquidation preferences and maximum fixed repurchase prices, in each case determined on a consolidated basis in
accordance with GAAP. For purposes hereof, the “maximum fixed repurchase price” of any Disqualified Stock or Preferred Stock that does not have a fixed repurchase price will be calculated in accordance with the terms of such
Disqualified Stock or Preferred Stock as if such Disqualified Stock or Preferred Stock were required to be repurchased by the Issuers thereof on any date on which Consolidated Total Indebtedness shall be required to be determined pursuant to the
indenture; provided, however, that if such Disqualified Stock or Preferred Stock could not be required to be repurchased at the time of such determination, the repurchase price will be the book value of such Disqualified Stock or
Preferred Stock as reflected in the most recent financial statements of such Person. 
 “continuing” means, with respect to
any Default or Event of Default, that such Default or Event of Default has not been cured or waived.
 “Corporate Trust Office of
the Trustee” will be at the address of the Trustee specified in Section 12.01 hereof or such other address as to which the Trustee may give notice to the Company. 

“Credit Agreement” means (i) the Credit Agreement dated as of May 7, 2015, by and among the Parent, the Company,
the other borrowers party thereto, the lenders named therein and from time to time party thereto, and, among others, Citibank, N.A., as administrative agent and collateral agent, including any related notes, Guarantees, collateral documents,
instruments and agreements executed in connection therewith, as such agreement, in whole or in part, in one or more instances, may be amended (including on the Issue Date), renewed, extended, substituted, refinanced, restructured, replaced (whether
or not upon termination, and whether with the original lenders or otherwise), supplemented or otherwise modified from time to time (including, in each case, by means of one or more credit agreements, note purchase agreements or sales of debt
securities to institutional investors whether with the original agents and lenders or otherwise and including, without limitation, any successive renewals, extensions, substitutions, refinancings, restructurings, replacements, supplementations or
other modifications of the foregoing) and including, without limitation, to increase the amount of available borrowing thereunder or to add Restricted Subsidiaries as additional borrowers or guarantors or otherwise, and (ii) whether or not the
credit agreement referred to in clause (i) remains outstanding, if designated by the Parent to be included in the definition of “Credit Agreement,” one or more (A) debt facilities or commercial paper facilities, providing for
revolving credit loans, term loans, receivables or inventory financing (including through the sale of receivables or inventory to lenders or to special purpose entities formed to borrow from lenders against such receivables or inventory, and
including Qualified Securitization Transactions) or letters of credit, (B) debt securities, indentures or other forms of debt financing (including convertible or exchangeable debt instruments or bank guarantees or bankers’ acceptances), or
(C) instruments or agreements evidencing any other Indebtedness, in each case, with the same or different borrowers, guarantors or issuers or lenders or group of lenders, and, in each case, as amended, supplemented, modified, extended,
restructured, renewed, refinanced, restated, replaced or refunded in whole or in part from time to time.

  
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 “Currency Agreement” means one or more of the following agreements which shall
be entered into by one or more financial institutions: foreign exchange contracts, currency swap agreements or other similar agreements or arrangements designed to protect against the fluctuations in currency values. 

“Custodian” means the Trustee, as custodian with respect to the Notes in global form, or any successor entity thereto.

 “Default” means any event that is, or with the passage of time or the giving of notice or both would be, an Event of
Default. 
 “Deferred Acquisition Consideration” means any purchase price adjustments, royalty, earn-out, Milestone
Payments, purchase price holdbacks, contingent or other deferred payment payments of a similar nature (including any non-compete payments and consulting payments) made in connection with any Permitted Investment or other acquisition (including the
acquisition of any intellectual property or license in respect thereof). 
 “Definitive Note” means a certificated Note
registered in the name of the Holder thereof and issued in accordance with Section 2.06 hereof, substantially in the form of Exhibit A hereto except that such Note shall not bear the Global Note Legend and shall not have the “Schedule of
Exchanges of Interests in the Global Note” attached thereto. 
 “Depositary” means, with respect to the Notes issuable
or issued in whole or in part in global form, the Person specified in Section 2.03 hereof as the Depositary with respect to the Notes, and any and all successors thereto appointed as depositary hereunder and having become such pursuant to the
applicable provision of this Indenture. 
 “Designated Noncash Consideration” means noncash consideration received by the
Parent or one of the Restricted Subsidiaries in connection with an Asset Sale that is designated by the Parent as Designated Noncash Consideration, less the amount of cash or cash equivalents received in connection with a subsequent sale of such
Designated Noncash Consideration, which cash and cash equivalents shall be considered Net Proceeds received as of such date and shall be applied pursuant to Section 4.10. 

“Disposition” means a sale, transfer, lease, disposition or exclusive license (but excluding licenses that are not Exclusive
Licenses), including any “Disposition” by means of a merger, consolidation or similar transaction. “Dispose” and “Disposed” as to any assets subject to a Disposition shall have a corollary meaning.

 “Disqualified Stock” means, with respect to any Person, any Capital Stock that by its terms (or by the terms of any
security into which it is convertible, or for which it is exchangeable, in each case, at the option of the holder) or upon the happening of any event: 

(1) matures or is mandatorily redeemable (other than redeemable only for Capital Stock of such Person which is not itself
Disqualified Stock) pursuant to a sinking fund obligation or otherwise; 
 (2) is convertible or exchangeable at the option
of the holder for Indebtedness or Disqualified Stock; or 
 (3) is mandatorily redeemable or must be purchased (in each case,
other than redeemable or purchasable only for Capital Stock of such Person which is not itself Disqualified Stock) upon the occurrence of certain events or otherwise, in whole or in part; 

  
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 in each case on or prior to the date that is 91 days after the Stated Maturity of the Notes; provided,
however, that any Capital Stock that would not constitute Disqualified Stock but for provisions thereof giving holders thereof the right to require such Person to purchase or redeem such Capital Stock upon the occurrence of an “asset
sale,” “fundamental change” or “change of control” occurring prior to the date that is 91 days after the Stated Maturity of the Notes shall not constitute Disqualified Stock if the “asset sale”, “fundamental
change” or “change of control” provisions applicable to such Capital Stock are not more favorable to the holders of such Capital Stock than the terms applicable to the Notes under Sections 4.10 and 4.14 or are subject to compliance by
the relevant Person with Section 4.07; provided, further, however, that if such Capital Stock is issued to any plan for the benefit of directors, managers, employees or consultants of the Parent or its Subsidiaries or by any
such plan to such directors, managers, employees or consultants, such Capital Stock shall not constitute Disqualified Stock solely because it may be required to be repurchased by the Parent or its Subsidiaries in order to satisfy applicable
statutory or regulatory obligations. 
 The amount of any Disqualified Stock that does not have a fixed redemption, repayment or repurchase
price will be calculated in accordance with the terms of such Disqualified Stock as if such Disqualified Stock were redeemed, repaid or repurchased on any date on which the amount of such Disqualified Stock is to be determined pursuant to this
Indenture; provided, however, that if such Disqualified Stock could not be required to be redeemed, repaid or repurchased by the Issuers thereof at the time of such determination, the redemption, repayment or repurchase price will be
the book value of such Disqualified Stock as reflected in the most recent financial statements of such Person.
 “Equity
Interests” means Capital Stock and all warrants, options or other rights to acquire Capital Stock (but excluding any Indebtedness that is convertible into, or exchangeable for, Capital Stock); provided that Permitted Convertible
Indebtedness Call Transactions shall not constitute Equity Interests. 
 “Equity Offering” means a public or private sale
either (1) of Equity Interests of the Parent by the Parent (other than Disqualified Stock and other than to a Subsidiary of the Parent) or (2) of Equity Interests of a direct or indirect parent entity of the Parent (other than to the
Parent or a Subsidiary of the Parent) to the extent that the net proceeds therefrom are contributed to the common equity capital of the Parent. 

“Exchange Act” means the Securities Exchange Act of 1934, as amended. 

“Exclusive License” means with respect to any drug or pharmaceutical product, any license granted to another Person to
develop, commercialize, sell, market and promote such drug or pharmaceutical product with a term greater than five (5) years (unless terminable prior to such time without material penalty or premium by the Parent or the applicable Restricted
Subsidiary) and which provides such Person (and/or its assignees) the exclusive rights to develop, commercialize, sell, market and promote such drug or product within the United States; provided that an “Exclusive License” shall not
include (a) any license to distribute any such drug or product on an exclusive basis within any particular geographic region or territory, (b) any licenses, which may be exclusive, to manufacture any such drug or product, and (c) any
license to manufacture, use, offer for sale or sell any authorized generic version of such drug or product. 
 “Fair Market
Value” means, with respect to any asset or property, the sale value that would be obtained in an arm’s-length free market transaction between an informed and willing seller under no compulsion to sell and an informed and willing buyer
under no compulsion to buy. Fair Market Value shall be determined in good faith by the Parent. 

  
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 “Fixed Charge Coverage Ratio” means, on any determination date (subject to the
second succeeding paragraph below, the “Transaction Date”), the ratio of Consolidated Adjusted EBITDA of the Parent for the most recent four consecutive fiscal quarters ending immediately prior to such determination date for which
internal financial statements are available (the “Four Quarter Period”) to Fixed Charges of the Parent for the Four Quarter Period. In addition to and without limitation of the foregoing, for purposes of this definition,
“Consolidated Adjusted EBITDA” and “Fixed Charges” shall be calculated after giving effect on a pro forma basis for the period of such calculation to: 

(1) the Incurrence or repayment of any Indebtedness and the issuance, maturity, redemption, conversion, exchange or repurchase
of any Disqualified Stock or Preferred Stock, as applicable, of the Parent or any of the Restricted Subsidiaries (and the application of the proceeds thereof) occurring during the Four Quarter Period or at any time subsequent to the last day of the
Four Quarter Period and on or prior to the Transaction Date, as if such Incurrence or repayment, as the case may be (and the application of the proceeds thereof), occurred on the first day of the Four Quarter Period; and 

(2) any Investments, acquisitions outside of the ordinary course of business (including the Acquisition), Dispositions outside
of the ordinary course of business (including Asset Sales), mergers, amalgamations, consolidations and disposed operations (as determined in accordance with GAAP) that have been made by the Parent or any Restricted Subsidiary during the Four Quarter
Period or subsequent to such Four Quarter Period and on or prior to or simultaneously with the Transaction Date shall be calculated on a pro forma basis assuming that all such Investments, acquisitions, Dispositions, mergers, amalgamations,
consolidations and disposed operations (and the change in any associated fixed charge obligations and the change in Consolidated Adjusted EBITDA resulting therefrom) had occurred on the first day of the Four Quarter Period. If since the
beginning of such Four Quarter Period any Person (that subsequently became a Restricted Subsidiary or was merged with or into the Parent or any Restricted Subsidiary since the beginning of such period) shall have made any Investment, acquisition,
Disposition, merger, consolidation or disposed operation that would have required adjustment pursuant to this definition, then the Fixed Charge Coverage Ratio shall be calculated giving pro forma effect thereto for such period as if such Investment,
acquisition, Disposition, merger, amalgamation, consolidation or disposed operation had occurred at the beginning of the applicable Four Quarter Period.

Furthermore, in calculating Fixed Charges for purposes of determining the denominator (but not the numerator) of this “Fixed Charge Coverage Ratio”:

 (1) interest on outstanding Indebtedness determined on a fluctuating basis as of the Transaction Date and that will
continue to be so determined thereafter shall be deemed to have accrued at a fixed rate per annum equal to the rate of interest on such Indebtedness in effect on the Transaction Date; 

(2) notwithstanding clause (1) above, interest on Indebtedness determined on a fluctuating basis, to the extent such
interest is covered by Interest Rate Agreements, shall be deemed to accrue at the rate per annum resulting after giving effect to the operation of such agreements; and 

(3) the amount of Fixed Charges attributable to any Preferred Stock (other than Disqualified Stock) issued by the Parent that
is mandatorily convertible or redeemable solely into common equity of the Parent within 365 days of the Transaction Date will be recalculated by multiplying (x) the actual amount of Fixed Charges attributable thereto for the Four Quarter
Period by (y) a fraction, the numerator of which is the number of days from (and including) the Transaction Date to (but excluding) the applicable conversion or redemption date and the denominator of which is 365.

  
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 Notwithstanding anything in this definition or anything else to the contrary, when calculating the Consolidated
Senior Secured Debt Ratio or the Fixed Charge Coverage Ratio, as applicable, in each case in connection with a Limited Condition Acquisition (and the other transactions to be entered into in connection therewith), the Transaction Date of such ratio
and of any default or event of default blocker shall, at the option of the Issuers, be the date the definitive agreements for such Limited Condition Acquisition are entered into and such ratios shall be calculated on a pro forma basis after giving
effect to such Limited Condition Acquisition and the other transactions to be entered into in connection therewith (including any incurrence of Indebtedness and the use of proceeds thereof) as if they occurred at the beginning of the four-quarter
reference period, and, for the avoidance of doubt, (x) if any such ratios are exceeded as a result of fluctuations in such ratio (including due to fluctuations in Consolidated Adjusted EBITDA of the Parent or the target company) at or prior to
the consummation of the relevant Limited Condition Acquisition, such ratios will not be deemed to have been exceeded as a result of such fluctuations solely for purposes of determining whether the Limited Condition Acquisition (and the other
transactions to be entered into in connection therewith) is permitted hereunder and (y) such ratios shall not be tested at the time of consummation of such Limited Condition Acquisition or related transactions; provided, further,
that if the Issuers elect to have such determinations occur at the time of entry into such definitive agreement, any such transaction shall be deemed to have occurred on the date the definitive agreements are entered and outstanding thereafter for
purposes of subsequently calculating any ratios under this Indenture after the date of such agreement and before the consummation of such Limited Condition Acquisition and to the extent baskets were utilized in satisfying any covenants, such baskets
shall be deemed utilized, but any calculation of Total Assets or Consolidated Net Income for purposes of other incurrences of Indebtedness or Liens or making of Restricted Payments (not related to such Limited Condition Acquisition) shall not
reflect such Limited Condition Acquisition until it is closed. 
 For purposes of this definition, whenever pro forma effect is to be given
to a transaction, the pro forma calculations shall be made in good faith by a responsible financial or accounting officer of the Parent, giving effect to (a) Pro Forma Cost Savings and (b) any cost savings that could then be reflected in
pro forma financial statements in accordance with Regulation S-X under the Securities Act or any other regulation or policy of the SEC related thereto. 

“Fixed Charges” means, with respect to any Person for any period, the sum, without duplication, of: 

(1) Consolidated Interest Expense for such period; plus  

(2) the amount of all dividend payments on any series of Preferred Stock or Disqualified Stock of the Parent or any Restricted
Subsidiary (other than dividends paid or accrued in Qualified Capital Stock or dividends paid or accrued to the Parent or any Restricted Subsidiary) paid, accrued or scheduled to be paid or accrued during such period (without duplication). 

“Foreign Subsidiary” means a Restricted Subsidiary that is not organized or existing under the laws of the United States of
America or any state or territory thereof or the District of Columbia.

  
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 “Four Quarter Period” has the meaning assigned to that term in the definition of
Fixed Charge Coverage Ratio. 
 “GAAP” means generally accepted accounting principles in the United States of America as in
effect on the Issue Date, including, without limitation, those set forth in the opinions and pronouncements of the Accounting Principles Board of the American Institute of Certified Public Accountants and statements and pronouncements of the
Financial Accounting Standards Board or in such other statements by such other entity as approved by a significant segment of the accounting profession. 

“Global Note Legend” means the legend set forth in Section 2.06(f)(2) hereof, which is required to be placed on all Global
Notes issued under this Indenture. 
 “Global Notes” means, individually and collectively, each of the Restricted Global
Notes and the Unrestricted Global Notes deposited with or on behalf of and registered in the name of the Depositary or its nominee, substantially in the form of Exhibit A hereto and that bears the Global Note Legend and that has the “Schedule
of Exchanges of Interests in the Global Note” attached thereto, issued in accordance with Section 2.01, 2.06(b)(3), 2.06(b)(4), 2.06(d)(1) or 2.06(d)(2) hereof. 

“Government Securities” means direct obligations (or certificates representing an ownership interest in such obligations) of
the United States of America (including any agency or instrumentality thereof) for the payment of which the full faith and credit of the United States of America is pledged and which are not callable at the issuer’s option. 

“Governmental Authority” means the government of the United States, any other nation or any political subdivision thereof,
whether state or local, and any agency, authority, instrumentality, regulatory body, court, central bank or other entity exercising executive, legislative, judicial, taxing, regulatory or administrative powers or functions of or pertaining to
government. 
 “Guarantee” means any obligation, contingent or otherwise, of any Person directly or indirectly guaranteeing
any Indebtedness of any other Person and any obligation, direct or indirect, contingent or otherwise, of such Person: 
 (1)
to purchase or pay (or advance or supply funds for the purchase or payment of) such Indebtedness of such other Person (whether arising by virtue of partnership arrangements, or by agreements to keep-well, to purchase assets, goods, securities or
services, to take-or-pay or to maintain financial statement conditions or otherwise); or 
 (2) entered into for the purpose
of assuring in any other manner the obligee against loss in respect thereof (in whole or in part); 
 provided, however, that the term
“Guarantee” shall not include: 
 (A) endorsements for collection or deposit in the ordinary course of business; or

 (B) a contractual commitment by one Person to invest in another Person for so long as such Investment is reasonably
expected to constitute a Permitted Investment under clause (3) of the definition of “Permitted Investment.” 

  
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 The term “Guarantee” used as a verb has a corresponding meaning.

“Guarantor” means the Parent or any Restricted Subsidiary of the Parent (other than the Issuers) that Guarantees the
obligations of the Issuers under the Notes, until such Note Guarantee is released in accordance with the terms of this Indenture. 

“Hedge Agreement” means any agreement with respect to any swap, forward, spot, future or derivative transaction or options or
similar agreement involving, or settled by reference to, one or more rates, currencies, commodities, equity or debt instruments or securities or economic, financial or pricing indices or measures of economic, financial or pricing risk or value or
any similar transaction or any combination of the foregoing. 
 “Hedging Obligations” means, with respect to any specified
Person, the obligations of such Person pursuant to any Interest Rate Agreement, Currency Agreement, Commodity Price Protection Agreement or any other similar agreement or arrangement. For the avoidance of doubt, any Permitted Equity Derivatives
will not constitute a Hedging Obligation. 
 “Holder” means a Person in whose name a Note is registered. 

“Horizon Limited” means Horizon Pharma Investment Limited, an exempted company incorporated under the laws of Bermuda and a
Wholly-Owned Subsidiary of the Parent. 
 “Hyperion” means Hyperion Therapeutics, Inc., a Delaware corporation. 

“IAI Global Note” means a Global Note substantially in the form of Exhibit A hereto bearing the Global Note Legend and the
Private Placement Legend and deposited with or on behalf of and registered in the name of the Depositary or its nominee that will be issued in a denomination equal to the outstanding principal amount of the Notes sold to Institutional Accredited
Investors. 
 “Immaterial Subsidiary” means, at any date of determination, each Restricted Subsidiary that (i) has not
guaranteed any other Indebtedness of the Parent and (ii) has total assets (as determined in accordance with GAAP) together with all other Subsidiaries that are not Guarantors by virtue of being Immaterial Subsidiaries and Consolidated Adjusted
EBITDA of less than 5.0% of the Parent’s Total Assets and Consolidated Adjusted EBITDA (measured, in the case of Total Assets, at the end of the most recent fiscal period for which internal financial statements are available and, in the case of
Consolidated Adjusted EBITDA, for the most recently ended four consecutive fiscal quarters ended for which internal consolidated financial statements are available, in each case measured on a pro forma basis giving effect to any acquisitions or
dispositions of companies, division or lines of business since such balance sheet date or the start of such Four Quarter Period, as applicable, and on or prior to the date of acquisition of such Subsidiary). 

“Incur” means issue, assume, Guarantee, incur or otherwise become liable for; provided, however, that any
Indebtedness of a Person existing at the time such Person becomes a Restricted Subsidiary (whether by merger, consolidation, acquisition or otherwise) shall be deemed to be Incurred by such Person at the time it becomes a Restricted
Subsidiary. The term “Incurrence” when used as a noun shall have a correlative meaning. 

  
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 Solely for purposes of determining compliance with Section 4.09, the following shall not be
deemed to be the Incurrence of Indebtedness: 
 (1) amortization of debt discount or the accretion of principal with respect
to a non-interest bearing or other discount security; 
 (2) the payment of regularly scheduled interest in the form of
additional Indebtedness of the same instrument or the payment of regularly scheduled dividends on Capital Stock in the form of additional Capital Stock of the same class and with the same terms; 

(3) changes in the fair value of Indebtedness (including the valuation of any Permitted Convertible Indebtedness attributable
to movement in the mark-to-market valuation thereof); and 
 (4) the obligation to pay a premium in respect of Indebtedness
arising in connection with the issuance of a notice of redemption, making of a mandatory offer to purchase such Indebtedness or any other prepayment thereof. 

In addition, the Issuers may, at their option, elect to treat all or any portion of the commitment under any Indebtedness (including with
respect to any revolving loan commitment) as being Incurred at the time of such commitment, in which case any subsequent Incurrence of Indebtedness under such commitment shall not be deemed to be an Incurrence at such subsequent time. 

“Indebtedness” means, with respect to any Person on any date of determination (without duplication): 

(1) the principal in respect of (A) indebtedness of such Person for money borrowed and (B) indebtedness evidenced by notes,
debentures, bonds or other similar instruments for the payment of which such Person is responsible or liable, including, in each case, any premium on such indebtedness to the extent such premium has become due and payable; 

(2) all Capital Lease Obligations of such Person; 

(3) the principal component of all obligations of such Person issued or assumed as the deferred purchase price of Property, all
conditional sale obligations of such Person and all obligations of such Person under any title retention agreement (but excluding any accounts payable, accrued expenses or other liability to trade creditors arising in the ordinary course of
business); 
 (4) all obligations of such Person for the reimbursement of any obligor on any letter of credit, bankers’
acceptance or similar credit transaction (other than obligations with respect to letters of credit securing obligations (other than obligations described in clauses (1) through (3) above) entered into in the ordinary course of business of such
Person to the extent such letters of credit are not drawn upon or, if and to the extent drawn upon, such drawing is reimbursed no later than the 30th day following payment on the letter of credit); 

(5) the amount of all obligations of such Person with respect to the redemption, repayment or other repurchase of any
Disqualified Stock of such Person or, with respect to any Preferred Stock of any Restricted Subsidiary of such Person, the principal amount of such Preferred Stock to be determined in accordance with this Indenture (but excluding, in each case, any
accrued dividends); 

  
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 (6) to the extent not otherwise included in this definition, Hedging Obligations
of such Person; 
 (7) all obligations of the type referred to in clauses (1) through (6) of other Persons and all dividends
of other Persons for the payment of which, in either case, such Person is responsible or liable, directly or indirectly, as obligor, guarantor or otherwise, including by means of any Guarantee; and 

(8) all obligations of the type referred to in clauses (1) through (7) of other Persons secured by any Lien on any property or
asset of such Person (whether or not such obligation is assumed by such Person), the amount of such obligation being deemed to be the lesser of the Fair Market Value of such property or assets and the amount of the obligation so secured; 

with respect to clauses (1), (2), (3) and (6) if and to the extent any of the preceding items would appear as a
liability upon the balance sheet of the specified Person in accordance with GAAP. Notwithstanding the foregoing, in connection with the purchase by the Parent or any Restricted Subsidiary of any business, the term “Indebtedness” will
exclude obligations in respect of deferred revenue, deferred compensation and severance, pension, health and welfare retirement and equivalent benefits to current or former employees, directors or managers of such Person and its Subsidiaries, and
any obligations in respect of Deferred Acquisition Consideration. 
 The amount of Indebtedness of any Person at any date shall be the
outstanding balance at such date of all obligations as described above; provided, however, that in the case of Indebtedness sold at a discount, the amount of such Indebtedness at any time will be the accreted value thereof at such
time. 
 “Indenture” means this Indenture, as amended or supplemented from time to time. 

“Indirect Participant” means a Person who holds a beneficial interest in a Global Note through a Participant. 

“Initial Notes” means the first $300.0 million aggregate principal amount of Notes issued under this Indenture on the date
hereof. 
 “Initial Purchasers” means Merrill Lynch, Pierce, Fenner & Smith Incorporated, J.P. Morgan Securities
LLC, Jefferies LLC, Citigroup Global Markets Inc. and Cowen and Company, LLC. 
 “Institutional Accredited Investor” means
an institution that is an “accredited investor” as defined in Rule 501(a)(1), (2), (3) or (7) under the Securities Act, who are not also QIBs. 

“Interest Rate Agreement” means one or more of the following agreements which shall be entered into by one or more financial
institutions: interest rate protection agreements (including, without limitation, interest rate swaps, caps, floors, collars and similar agreements) and/or other types of interest rate hedging agreements from time to time.

“Investments” means, with respect to any Person, all direct or indirect investments by such Person in other Persons
(including Affiliates) in the form of loans (including Guarantees or other obligations), advances or capital contributions (excluding commission, travel and similar advances to officers and employees made in the ordinary course of business),
purchases or other acquisitions for consideration of Indebtedness, Equity Interests or other securities, together with all items that are or would be classified as investments on a balance sheet prepared in accordance with GAAP. If the Parent
or any Restricted Subsidiary sells or otherwise disposes of any Equity Interests of any direct or indirect Restricted 

  
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Subsidiary such that, after giving effect to any such sale or disposition, such Person is no longer a Restricted Subsidiary, the Parent will be deemed to have made an Investment on the date of
any such sale or disposition equal to the Fair Market Value of the Parent’s Investments in such Subsidiary that were not sold or disposed of in an amount determined as provided in Section 4.07(c). The acquisition by the Parent or any
Restricted Subsidiary of a Person that holds an Investment in a third Person will be deemed to be an Investment by the Parent or such Restricted Subsidiary in such third Person in an amount equal to the Fair Market Value of the Investments held by
the acquired Person in such third Person in an amount determined as provided in Section 4.07(c). Except as otherwise provided in this Indenture, the amount of an Investment will be determined at the time the Investment is made and without
giving effect to subsequent changes in value, less any amounts paid, repaid, refinanced, distributed or otherwise received in cash in respect of such Investment. For the avoidance of doubt, Permitted Equity Derivatives and acquisitions of or
licenses for intellectual property or tangible assets used or useful in a Permitted Business do not constitute Investments.
 “Issue
Date” means October 25, 2016. 
 “Issuers” refers collectively to the Company and the Co-Issuer. 

“Legal Holiday” means a Saturday, a Sunday or a day on which banking institutions in the City of New York or at a Place of
Payment are authorized by law, regulation or executive order to remain closed. If a payment date is a Legal Holiday at a Place of Payment, payment may be made at that place on the next succeeding day that is not a Legal Holiday, and no interest
shall accrue on such payment for the intervening period. 
 “Lien” means any mortgage, pledge, security interest,
encumbrance, lien or charge of any kind (including any conditional sale or other title retention agreement or lease in the nature thereof). 

“Limited Condition Acquisition” means any acquisition, including by means of a merger, amalgamation or consolidation, by the
Parent or one or more of its Restricted Subsidiaries, the consummation of which is not conditioned upon the availability of, or on obtaining, third party financing. 

“Merger” means the merger of Purchaser with and into Raptor with Raptor continuing as the surviving corporation in such
merger. 
 “Merger Agreement” means that certain Agreement and Plan of Merger, among the Parent, Purchaser and Raptor as of
September 12, 2016, together with all exhibits, annexes, schedules and other disclosure letters thereto and after giving effect to any alternation, amendment, modification, supplement or waiver thereto. 

“Milestone Payments” means payments made in connection with any Permitted Investment or other acquisition (including any
license or the acquisition of any license) of any rights in respect of any drug or other pharmaceutical product (and any related property or assets) to sellers (or licensors) of the assets or Equity Interests acquired (or licensed) therein based on
the achievement of specified revenue, profit or other performance targets (financial or otherwise). 
 “Moody’s” means
Moody’s Investors Service, Inc., and any successor to its rating agency business. 
 “Net Cash Proceeds” means with
respect to a transaction, the proceeds of such transaction in the form of cash or Cash Equivalents including payments in respect of deferred payment obligations when received in the form of, or stock or other assets when disposed of for, cash or
Cash Equivalents (except to 

  
 20 








 
the extent that such obligations are financed or sold with recourse to the Parent or any Restricted Subsidiary), net of attorney’s fees, accountant’s fees and brokerage, consultation,
underwriting, taxes and other fees and expenses actually incurred or reserved in good faith for post-closing adjustments in connection with such transaction and net of taxes paid or payable as a result thereof. 

“Net Proceeds” from an Asset Sale means cash payments received therefrom (including any cash payments received by way of
deferred payment of principal pursuant to a note or installment receivable or otherwise and proceeds from the sale or other disposition of any securities received as consideration, but only as and when received, but excluding any other consideration
received in the form of assumption by the acquiring Person of Indebtedness or other obligations relating to such properties or assets or received in any other non-cash form), in each case net of: 

(1) all legal, title and recording tax expenses, commissions and other fees and expenses incurred, and all Federal, state,
provincial, foreign and local taxes paid, reasonably estimated to be payable or required to be accrued as a liability under GAAP, as a consequence of such Asset Sale (including, for the avoidance of doubt, any income, withholding and other taxes
payable as a result of the distribution, contribution or other transfer of such proceeds to the Issuers and after taking into account any available tax credits or deductions and any tax sharing agreements); 

(2) all payments made on any Indebtedness which is secured by any assets subject to such Asset Sale, in accordance with the
terms of any Lien upon or other security agreement of any kind with respect to such assets, or which must by its terms, or in order to obtain a necessary consent to such Asset Sale, or by applicable law, be repaid out of the proceeds from such Asset
Sale; 
 (3) all distributions and other payments required to be made to minority interest holders in Restricted Subsidiaries
or joint ventures as a result of such Asset Sale; 
 (4) the amount of any reserves established to fund contingent
liabilities reasonably estimated by the Issuers to be payable in respect of such Asset Sale; and 
 (5) any portion of the
purchase price from an Asset Sale placed in escrow, whether as a reserve for adjustment of the purchase price, for satisfaction of indemnities in respect of such Asset Sale or otherwise in connection with that Asset Sale; provided,
however, that upon the termination of that escrow, Net Proceeds will be increased by any portion of funds in the escrow that are released to the Parent or any Restricted Subsidiary (subject to any reserves established in respect thereof).

“Non-Guarantor Subsidiary” means a Restricted Subsidiary that is not a Guarantor.

“Non-U.S. Person” means a Person who is not a U.S. Person. 

“Note Guarantee” means the Guarantee by each Guarantor of the obligations of the Issuers under this Indenture and the Notes.

 “Notes” has the meaning assigned to it in the preamble to this Indenture. The Initial Notes and the Additional
Notes shall be treated as a single class for all purposes under this Indenture, and unless the context otherwise requires, all references to the Notes shall include the Initial Notes and any Additional Notes. 

  
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 “Obligations” means any principal, interest, penalties, fees, indemnifications,
reimbursements, damages and other liabilities payable under the documentation governing any Indebtedness. 
 “Offer to
Purchase” means a Change of Control Offer or an Asset Sale Offer. 
 “Offering Memorandum” means the final
offering memorandum of the Issuers, dated as of October 19, 2016, relating to the Notes. 
 “Officer” means, with respect
to any Person, the Chairman of the Board, the Chief Executive Officer, the President, the Chief Operating Officer, the Chief Financial Officer, the Treasurer, any Assistant Treasurer, the Controller, any assistant Controller, the Secretary, any
Assistant Secretary or any Vice-President of such Person. 
 “Officer’s Certificate” means a certificate signed by an
Officer of the Parent or the Issuers, as applicable, and delivered to the Trustee.
 “Opinion of Counsel” means an opinion
meeting the requirements of this Indenture from legal counsel who is reasonably acceptable to the Trustee and delivered to the Trustee. The counsel may be an employee of or counsel to the Company, any Subsidiary of the Company or the Trustee.

 “Parent” means Horizon Pharma Public Limited Company, a public limited company organized under the laws of Ireland. 

“Participant” means, with respect to the Depositary, Euroclear or Clearstream, a Person who has an account with the
Depositary, Euroclear or Clearstream, respectively (and, with respect to DTC, shall include Euroclear and Clearstream). 

“Permitted Bond Hedge Transaction” means (a) any call option or capped call option (or substantively equivalent
derivative transaction) on the common or ordinary Capital Stock of the Parent (or any direct or indirect parent company thereof) purchased by the Parent or any of its Subsidiaries in connection with an Incurrence of Permitted Convertible
Indebtedness, and (b) any call option or capped call option (or substantively equivalent derivative transaction) replacing or refinancing the foregoing; provided, that (x) the sum of (i) the purchase price for any Permitted
Bond Hedge Transaction occurring after the Issue Date, plus (ii) the purchase price for any Permitted Bond Hedge Transaction it is refinancing or replacing, if any, minus (iii) the cash proceeds received upon the termination or the
retirement of the Permitted Bond Hedge Transaction it is replacing or refinancing, if any, less (y) the sum of (i) the cash proceeds from the sale of the related Permitted Warrant Transaction plus (ii) the cash proceeds from the sale
of any Permitted Warrant Transaction refinancing or replacing such related Permitted Warrant Transaction, if any, minus (iii) the amount paid upon termination or retirement of such related Permitted Warrant Transaction, if any, does not exceed
the net cash proceeds from the Incurrence of the related Permitted Convertible Indebtedness.
 “Permitted Business” means
the business and any services, activities or businesses incidental, or reasonably related or complementary or similar to, any line of business engaged in by the Parent and its Subsidiaries or Raptor and its Subsidiaries in each case as of the Issue
Date or any business activity that is a reasonable extension, development or expansion thereof or ancillary thereto.
 “Permitted
Convertible Indebtedness” means (a) Indebtedness of the Parent or any of the Restricted Subsidiaries (which may be Guaranteed by the Guarantors) permitted to be Incurred pursuant to Section 4.09 that is (1) convertible into, or
exchangeable for, Capital Stock of the Parent or any of its direct or indirect parent companies (and cash in lieu of fractional shares) and/or cash (in an amount 

  
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determined by reference to the price of such common or ordinary Capital Stock) and/or (2) sold as units with call options, warrants, rights or obligations to purchase (or substantially
equivalent derivative transactions) that are exercisable for Capital Stock of the Parent or any of its direct or indirect parent companies and/or cash (in an amount determined by reference to the price of such common or ordinary Capital Stock) and
(b) the 2022 Notes.
 “Permitted Convertible Indebtedness Call Transaction” means any Permitted Bond Hedge Transaction
and any Permitted Warrant Transaction.
 “Permitted Equity Derivatives” means (a) any forward purchase, accelerated
share purchase or other equity derivative transactions relating to the Capital Stock of the Parent entered into by the Parent or any Restricted Subsidiary provided that any Restricted Payment made in connection with such transaction is permitted
pursuant to the covenant described under Section 4.07 and (b) any Permitted Convertible Indebtedness Call Transactions. 

“Permitted Investments” means:

(1) any Investment in the Parent or in a Restricted Subsidiary of the Parent; 

(2) any Investment in Cash Equivalents; 

(3) any Investment by the Parent or any Restricted Subsidiary in a Person, if as a result of such Investment: (a) such
Person becomes a Restricted Subsidiary; or (b) such Person is merged, consolidated or amalgamated with or into, or transfers or conveys substantially all of its assets to, or is liquidated into, the Parent or a Restricted Subsidiary; and, in
each case, any Investment held by such Person that was not acquired by such Person in contemplation of such acquisition, merger, consolidation, transfer, conveyance or liquidation; 

(4) any Investment made as a result of the receipt of non-cash consideration from (a) an Asset Sale that was made pursuant
to and in compliance with Section 4.10 or (b) a Disposition or other transfer of assets not constituting an Asset Sale; 

(5) any Investments to the extent made in exchange for the issuance of Equity Interests (other than Disqualified Stock) of the
Parent or any of its direct or indirect parent companies; 
 (6) (a) any Investments received in settlement, satisfaction,
compromise or resolution of (i) obligations owed to the Parent or any of its Restricted Subsidiaries created in the ordinary course of business, including pursuant to any plan of reorganization or similar arrangement upon the bankruptcy or
insolvency of any trade creditor or customer; or (ii) judgments, litigation, arbitration or other disputes, and (b) Investments by the Parent or any of its Restricted Subsidiaries in a Securitization Special Purpose Entity or any
Investment by a Securitization Special Purpose Entity in any other Person, in each case, in connection with a Qualified Securitization Transaction and in an amount not to exceed $75.0 million; 

(7) Investments represented by Hedging Obligations and Permitted Bond Hedge Transactions; 

(8) loans or advances, and guarantees of such loans and advances, to officers, directors consultants, employees, customers and
suppliers of the Parent, any of its Subsidiaries or any of the Parent’s direct or indirect parent companies in the ordinary course of business in the aggregate amount outstanding at any one time not to exceed $7.5 million; 

  
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 (9) Investments in the Notes, the 2022 Notes or the 2023 Notes; 

(10) any guarantee of Indebtedness permitted to be incurred by Section 4.09 and performance guarantees consistent with past
practice; 
 (11) any Investment existing on, or made pursuant to binding commitments existing on, the Issue Date and any
Investment consisting of an extension, modification or renewal of any Investment existing on, or made pursuant to a binding commitment existing on, the Issue Date; provided that the amount of any such Investment may be increased (a) as
required by the terms of such Investment as in existence on the Issue Date or (b) as otherwise permitted under this Indenture; 

(12) Investments in the ordinary course of business in prepaid expenses, negotiable instruments held for collection and lease,
utility and worker’s compensation, performance and other similar deposits provided to third parties; 
 (13) receivables
owing to the Parent or any Restricted Subsidiary if created or acquired in the ordinary course of business and payable or dischargeable in accordance with customary trade terms; provided, however, that such trade terms may include such
concessionary trade terms as the Parent or any such Restricted Subsidiary deems reasonable under the circumstances; 
 (14)
advances, loans or extensions of trade or other credit (including to officers, directors, consultants and employees of the Parent, its Subsidiaries or its direct and indirect parent companies) in the ordinary course of business by the Parent’s
or any of the Restricted Subsidiaries; 
 (15) lease, utility and other similar deposits in the ordinary course of business
and other deposits constituting Permitted Liens; 
 (16) Investments in the ordinary course of business consisting of
endorsements for collection or deposit; 
 (17) Investments in a Permitted Business in an aggregate amount, taken together
with all other Investments made pursuant to this clause (17) that are at that time outstanding, not to exceed the greater of $60.0 million or 2.0% of Total Assets (with the Fair Market Value of each Investment being measured at the time made
and without giving effect to subsequent changes in value); 
 (18) Investments in (a) any joint ventures in an amount
outstanding at any one time not to exceed $60.0 million or 2.0% of Total Assets (with the Fair Market Value of each Investment (other than any Investment consisting of a guarantee) being measured at the time made and without giving effect to
subsequent changes in value) and (b) any Permitted Joint Venture; provided, however, that if any Investment pursuant to this clause (18) is made in any Person that is not a Restricted Subsidiary at the date of the making of
such Investment and such Person becomes a Restricted Subsidiary after such date, such Investment shall thereafter be deemed to have been made pursuant to clause (1) above and shall cease to have been made pursuant to this clause (18) for
so long as such Person continues to be a Restricted Subsidiary; 

  
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 (19) Investments among the Parent and its Subsidiaries in the ordinary course of
business for purposes of funding the working capital and maintenance capital expenditure requirements and research and development activities of the Parent and its Subsidiaries; 

(20) Investments in connection with the Transactions; 

(21) Investments consisting of co-development agreements or consisting of the licensing or contribution of intellectual
property, new drug applications or similar assets pursuant to development, marketing or manufacturing agreements, alliances or arrangements or similar agreements or arrangements with other Persons; 

(22) Investments consisting of purchases and acquisitions of inventory, supplies, materials and equipment or purchases of
contract rights or licenses or leases of intellectual property, in each case in the ordinary course of business; 
 (23) any
customary upfront, milestone, marketing or other funding payment in the ordinary course of business to another Person in connection with obtaining a right to receive royalty or other payments in the future; and 

(24) other Investments in any Person having an aggregate Fair Market Value (measured on the date each such Investment was made
and without giving effect to subsequent changes in value), when taken together with all other Investments made pursuant to this clause (24) that are at the time outstanding, not to exceed the greater of $150.0 million or 4.0% of Total Assets.

 “Permitted Joint Venture” means any joint venture (which may be in the form of a limited liability company, partnership,
corporation or other entity) in which the Parent or any of the Restricted Subsidiaries is a joint venturer; provided, however, that, immediately after giving effect to any Investment in such Permitted Joint Venture pursuant to clause
(18)(b) of the definition of “Permitted Investments”: (a) the joint venture is engaged solely in a Permitted Business, (b) the Parent or a Restricted Subsidiary is required by the governing documents of the joint venture or
an agreement with the other parties to the joint venture to participate in the management of such joint venture as a member of such joint venture’s Board of Directors or otherwise, (c) the Parent and any Subsidiary or Affiliate of the
Parent hold or own, collectively, not more than 66 2/3 percent of the
outstanding Capital Stock of such Permitted Joint Venture, and (d) at the time of the initial Investment and at the time of each subsequent Investment in such Permitted Joint Venture, the Parent would be able to Incur additional Secured
Indebtedness pursuant to the first proviso in Section 4.09(a).
 “Permitted Liens” means:

(1) Liens to secure (a) Indebtedness (and other related Obligations) that was incurred pursuant to clause (1) or
clause (14) of the definition of Permitted Debt and Hedging Obligations related thereto, (b) Obligations with regard to Treasury Management Arrangements, or (c) Indebtedness existing by reason of other contractual requirements of a
Securitization Special Purpose Entity or any Standard Securitization Undertaking, in each case in respect of this subclause (c) in connection with a Qualified Securitization Transaction in an amount not to exceed $75.0 million; 

(2) (a) Liens on assets of Foreign Subsidiaries or Non-Guarantor Subsidiaries securing Indebtedness (and other related
Obligations) of such Foreign Subsidiary or Non-Guarantor Subsidiary that was Incurred pursuant to clause (12) of Permitted Debt, (b) Liens 

  
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securing Indebtedness (and other related Obligations) that was Incurred pursuant to clause (22) of the definition of Permitted Debt, and (c) Liens to secure Indebtedness (and other
related Obligations) that was Incurred pursuant to Section 4.09, provided that, in the case of this clause (c), at the time of its Incurrence and after giving pro forma effect thereto, the Consolidated Senior Secured Debt Ratio would be no
greater than 3.5 to 1.0; 
 (3) (a) Liens in favor of the Issuers or the Guarantors; (b) Liens on the property of any
Restricted Subsidiary that is not a Guarantor in favor of any other Restricted Subsidiary and (c) Liens on the property of any Subsidiary of the Parent that is not a Restricted Subsidiary in favor of the Parent or any of the Restricted
Subsidiaries; 
 (4) Liens on property or Equity Interests of another Person existing at the time such other Person becomes a
Restricted Subsidiary of the Parent or is merged with or into or consolidated with the Parent or any Subsidiary of the Parent; provided that such Liens do not extend to any other property owned by the Parent or any of the Restricted
Subsidiaries (other than assets and property affixed or appurtenant thereto); 
 (5) Liens on property (including Equity
Interests) existing at the time of acquisition of the property by the Parent or any Restricted Subsidiary of the Parent; provided that such Liens were in existence prior to such acquisition and not incurred in contemplation of, such
acquisition; 
 (6) Liens on the Equity Interests of Unrestricted Subsidiaries; 

(7) Liens to secure the performance of, or arising in connection with, public or statutory obligations (including worker’s
compensation laws, unemployment insurance laws or similar legislation), insurance, surety or appeal bonds, performance bonds or other obligations of a like nature, good faith deposits in connection with bids, tenders, contracts (other than for the
payment of Indebtedness) or leases, deposits as security for contested taxes or import duties or for the payment of rent, in each case Incurred in the ordinary course of business (including Liens to secure letters of credit or similar instruments
issued to assure payment or performance of such obligations); 
 (8) Liens on securities that are the subject of repurchase
agreements permitted hereunder; 
 (9) Liens to secure Indebtedness (including Capital Lease Obligations) permitted by clause
(11) of the definition of Permitted Debt covering only the assets acquired with, improved, constructed, leased or financed by such Indebtedness and the proceeds thereof; 

(10) Liens existing on the Issue Date (other than Liens referred to in the foregoing clause (1)(a)); 

(11) Liens for taxes, assessments or other governmental charges or claims that are (a) not yet delinquent, or
(b) being contested in good faith by appropriate proceedings and with respect to which adequate reserves have been established in accordance with, and to the extent required by, applicable accounting standards; 

(12) Liens imposed by law, such as carriers’, warehousemen’s, landlord’s and mechanics’ Liens, in each
case, either (a) incurred in the ordinary course of business or (b) for sums not yet due or being contested in good faith by appropriate proceedings; 

  
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 (13) survey exceptions, encumbrances, easements or reservations of, or rights of
others for, licenses, rights-of-way, sewers, electric lines, telegraph and telephone lines and other similar purposes, or zoning or other restrictions as to the use of real property or Liens incidental to the conduct of the business of such Person
or to the ownership of their properties which were not incurred in connection with Indebtedness and that do not in the aggregate materially adversely affect the value of said properties or materially impair their use in the operation of the business
of such Person; 
 (14) Liens created for the benefit of (or to secure) the Notes (or the Note Guarantees); 

(15) Liens to secure any Permitted Refinancing Indebtedness permitted to be incurred under this Indenture or to secure any
Refinancing (or successive Refinancings), as a whole or in part, of any Indebtedness secured by a Lien referred to in clauses (2)(c), (4), (5), (9), (10) and (37) hereof; provided, however, that the new Lien is limited to property
and assets that secured or, under the written agreements pursuant to which the original Liens arose, could secure the Refinanced Indebtedness (plus improvements and accessions to, such property or proceeds or distributions thereof); 

(16) Liens on insurance policies, premiums and proceeds thereof, or other deposits, to secure insurance premium financings and
other liabilities to insurance carriers; 
 (17) Liens arising from Uniform Commercial Code (“UCC”)
financing statement filings regarding operating leases or consignments entered into by the Parent and the Restricted Subsidiaries and other precautionary UCC financing statements or similar filings; 

(18) Liens securing or arising out of judgments, decrees, orders, awards or notices of lis pendens and associated rights
related to litigation with respect to which such Person shall then be proceeding with an appeal or other proceedings for review, or in respect of which the period within which such appeal or proceedings may be initiated shall not have expired, and
Liens on litigation proceeds securing obligations to pay expenses incurred in connection with such litigation; 
 (19) Liens
arising by virtue of any statutory or common law provisions relating to banker’s liens and rights of set-off or similar rights and remedies as to deposit accounts or other funds maintained with a depository or financial institution or as to
purchase orders and other agreements entered into with customers in the ordinary course of business; 
 (20) Liens on cash,
Cash Equivalents or other property arising in connection with the defeasance, discharge or redemption of Indebtedness; 

(21) Liens on cash, Cash Equivalents or other property securing Indebtedness permitted by clause (16) of the definition of
Permitted Debt; 
 (22) Liens on specific items of inventory or other goods (and the proceeds thereof) of any Person securing
such Person’s obligations in respect of bankers’ acceptances issued or created for the account of such Person to facilitate the purchase, shipment or storage of such inventory or other goods; 

(23) grants of software and other technology licenses in the ordinary course of business; 

  
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 (24) Liens arising out of conditional sale, title retention, consignment or
similar arrangements for the sale of goods entered into in the ordinary course of business; 
 (25) Liens in favor of issuers
of performance and surety bonds or bid bonds or letters of credit issued pursuant to the request of and for the account of such Person in the ordinary course of its business; 

(26) Liens securing Indebtedness or other obligations of a Subsidiary of such Person owing to such Person or a Wholly-Owned
Subsidiary of such Person; 
 (27) Liens securing Hedging Obligations so long as such Hedging Obligations are permitted to be
incurred under this Indenture; 
 (28) Liens in favor of customs and revenue authorities arising as a matter of law to secure
payment of customs duties in connection with the importation of goods in the ordinary course of business; 
 (29) Liens on
equipment or inventory of the Parent or any Restricted Subsidiary granted in the ordinary course of business to the Parent’s or such Restricted Subsidiary’s supplier at which such equipment or inventory is located; 

(30) any encumbrance or restriction (including put and call arrangements) with respect to Capital Stock of any joint venture,
minority investment or similar arrangement pursuant to any joint venture, shareholder, investor rights or similar agreement; 

(31) Liens (a) solely on any deposits made by the Parent or any of the Restricted Subsidiaries in connection with any
letter of intent or purchase agreement in respect of any Investment permitted under this Indenture or (b) consisting of an agreement to dispose of any property permitted to be sold pursuant to Section 4.10; 

(32) leases, subleases, licenses or sublicenses granted to third parties entered into in the ordinary course of business which
do not materially interfere with the conduct of the business of the Parent and the Restricted Subsidiaries and which do not secure any Indebtedness; 

(33) Liens (a) of a collection bank arising under Section 4-210 of the Uniform Commercial Code on items in the course
of collection and (b) attaching to commodity trading accounts or other commodities brokerage accounts incurred in the ordinary course of business, including Liens encumbering reasonable customary initial deposits and margin deposits; 

(34) ground leases in respect of real property on which facilities owned or leased by the Parent or any of its Subsidiaries are
located and other Liens affecting the interest of any landlord (and any underlying landlord) of any real property leased by the Parent or any Subsidiary; 

(35) Liens to secure contractual payments (contingent or otherwise) payable by the Parent or its Subsidiaries to a seller after
the consummation of an acquisition of a product, business, license or other assets; 
 (36) Liens on any assets held by a
trustee (i) under any indenture or other debt instrument where the proceeds of the securities issued thereunder are held in escrow pursuant to customary escrow arrangements pending the release thereof, and (ii) under any indenture pursuant to
customary discharge, redemption or defeasance provisions; and 
 (37) other Liens securing Indebtedness to the extent such
Indebtedness, when taken together with all other Indebtedness secured by Liens Incurred pursuant to this clause (37) that are at that time outstanding and the Indebtedness secured by Liens pursuant to clause (15) above with respect to the
Refinancing of Indebtedness originally secured by Liens pursuant to this clause (37), does not exceed the greater of $15.0 million or 1.0% of Total Assets. 

  
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 For the avoidance of doubt, the inclusion of any specific Lien in the definition of Permitted
Liens shall not give rise to any implication that the obligations secured by such Lien constitute Indebtedness. 
 For purposes of
determining compliance with this definition, (A) Permitted Liens need not be incurred solely by reference to one category of Permitted Liens described above but are permitted to be incurred in part under any combination thereof and (B) in
the event that a Lien (or any portion thereof) meets the criteria of one or more of the categories of Permitted Liens described above, the Parent may, in its sole discretion, classify or reclassify such item of Permitted Liens (or any portion
thereof) in any manner that complies with this definition and the Parent may divide and classify a Lien in more than one of the types of Permitted Liens in one of the above clauses.

“Permitted Refinancing Indebtedness” means any Indebtedness that Refinances any Indebtedness of the Parent or any of the
Restricted Subsidiaries (other than intercompany Indebtedness), including Indebtedness that Refinances Refinanced Indebtedness; provided that: 

(1) the principal amount (or accreted value, if applicable) of such Permitted Refinancing Indebtedness does not exceed the
principal amount (or accreted value, if applicable) of the Indebtedness being Refinanced (plus accrued interest and premium (including tender premium) thereon, any committed or undrawn amounts associated with, original issue discount on, and
underwriting discounts, fees, commissions and expenses incurred in connection with, such Refinancing); 
 (2) such Permitted
Refinancing Indebtedness has a final maturity date no earlier than the earlier of (i) the final maturity date of the Notes or (ii) the final maturity of the Indebtedness being Refinanced, and has a Weighted Average Life to Maturity that is
equal to or greater than the Weighted Average Life to Maturity of the Indebtedness being Refinanced; 
 (3) if the
Indebtedness being Refinanced is contractually subordinated in right of payment to the Notes, such Permitted Refinancing Indebtedness is contractually subordinated in right of payment to the Notes on terms at least as favorable to the holders of
Notes as those contained in the documentation governing the Indebtedness being Refinanced; and 
 (4) no Permitted
Refinancing Indebtedness shall have direct obligors or contingent obligors that were not the direct obligors or contingent obligors (or that would not have been required to become direct obligors or contingent obligors) in respect of the
Indebtedness being Refinanced.
 “Permitted Warrant Transaction” means any call options, warrants or rights to purchase (or
substantively equivalent derivative transactions) on common or ordinary Capital Stock of the Parent or any of its direct or indirect parent companies purchased or sold by the Parent, any of its Subsidiaries or any of the Parent’s direct or
indirect parent companies substantially concurrently with a Permitted Bond Hedge Transaction.

  
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 “Person” means any individual, corporation, partnership, joint venture,
association, joint-stock company, trust, unincorporated organization, limited liability company or government or other entity. 

“Place of Payment”, when used with respect to the Notes, means the place or places where the principal of (and premium, if
any) and interest on the Notes are payable as contemplated by Section 4.02 hereof. 
 “Private Placement Legend” means
the legend set forth in Section 2.06(f)(1) hereof. 
 “Preferred Stock”, as applied to the Capital Stock of any Person,
means Capital Stock of any class of classes (however designated) which is preferred as to the payment of dividends or distributions, or as to the distribution of assets upon any voluntary or involuntary liquidation or dissolution of such Person,
over shares of Capital Stock of any other class of such Person.
 “Product” means any product developed, acquired,
produced, marketed or promoted by the Parent or any of its Subsidiaries in connection with the conduct of a Permitted Business.

“Property” means any right or interest in or to property of any kind whatsoever, whether real, personal or mixed and whether
tangible or intangible, including, without limitation, Capital Stock.
 “Purchase Money Indebtedness” means Indebtedness
Incurred to finance the acquisition, development, construction or lease by the Parent or a Restricted Subsidiary of Property, including additions and improvements thereto; provided, however, that such Indebtedness is Incurred within
270 days after the completion of the acquisition, development, construction or lease of such Property by the Parent or such Restricted Subsidiary. 

“Purchaser” means Misneach Corporation, a Delaware corporation. 

“QIB” means a “qualified institutional buyer” as defined in Rule 144A. 

“Qualifying Equity Interests” means Equity Interests of the Parent other than (1) Disqualified Stock and (2) Equity
Interests sold in an Equity Offering prior to the third anniversary of the Issue Date that were used to support an optional redemption of Notes pursuant to Section 3.07.

“Qualified Securitization Transaction” means any transaction or series of transactions that may be entered into by the Parent
or any of its Restricted Subsidiaries pursuant to which the Parent or such Restricted Subsidiary may sell, convey, grant a security interest in or otherwise transfer to a Securitization Special Purpose Entity, and such Securitization Special Purpose
Entity may sell, convey, grant a security interest in or otherwise transfer to any other Person, any Securitization Program Assets (whether now existing or arising in the future). 

“Raptor” means Raptor Pharmaceutical Corp., a Delaware corporation. 

“Receivables” means any accounts, leases, payment intangibles and other financial assets (including without limitation, any
financing contracts and royalty receivables) together with other assets that are customarily transferred, sold and/or pledged in connection with a Qualified Securitization Transaction and proceeds thereof. 

“Refinance” means, in respect of any Indebtedness, to refinance, extend, renew, refund, repay, prepay, purchase, redeem,
defease or retire, or to issue other Indebtedness in exchange or replacement for, such Indebtedness. “Refinanced” and “Refinancing” shall have correlative meanings.

  
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 “Regulation S” means Regulation S promulgated under the Securities Act. 

“Regulation S Global Note” means a Regulation S Temporary Global Note or Regulation S Permanent Global Note, as appropriate.

 “Regulation S Permanent Global Note” means a permanent Global Note in the form of Exhibit A hereto bearing the
Global Note Legend and the Private Placement Legend and deposited with or on behalf of and registered in the name of the Depositary or its nominee, issued in a denomination equal to the outstanding principal amount of the Regulation S Temporary
Global Note upon expiration of the Restricted Period. 
 “Regulation S Temporary Global Note” means a temporary Global Note
in the form of Exhibit A hereto deposited with or on behalf of and registered in the name of the Depositary or its nominee, issued in a denomination equal to the outstanding principal amount of the Notes initially sold in reliance on Rule 903
of Regulation S. 
 “Regulation S Temporary Global Note Legend” means the legend set forth in Section 2.06(f)(3)
hereof. 
 “Responsible Officer” when used with respect to the Trustee, means any officer within the corporate trust
department of the Trustee (or any successor group of the Trustee) or any other officer of the Trustee customarily performing functions similar to those performed by any of the above designated officers and also means, with respect to a particular
corporate trust matter, any other officer to whom such matter is referred because of his knowledge of and familiarity with the particular subject and, in each case, who shall have direct responsibility for the administration of this Indenture. 

“Restricted Definitive Note” means a Definitive Note bearing the Private Placement Legend. 

“Restricted Global Note” means a Global Note bearing the Private Placement Legend. 

“Restricted Investment” means an Investment other than a Permitted Investment. 

“Restricted Note” means a Note required to bear the Private Placement Legend. 

“Restricted Period” means the 40-day distribution compliance period as defined in Regulation S. 

“Restricted Subsidiary” means any Subsidiary of the Parent (as defined at such time) that is not an Unrestricted Subsidiary.

 “Rule 144” means Rule 144 promulgated under the Securities Act. 

“Rule 144A” means Rule 144A promulgated under the Securities Act. 

“Rule 903” means Rule 903 promulgated under the Securities Act. 

“Rule 904” means Rule 904 promulgated under the Securities Act. 

“Secured Indebtedness” means any Indebtedness of the Parent or any of the Restricted Subsidiaries secured by a Lien. 

“SEC” means the Securities and Exchange Commission. 

  
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 “Securities Act” means the Securities Act of 1933, as amended. 

“Securitization Program Assets” means (i) all Receivables transferred in connection with asset securitization
transactions by the Parent or any of its Restricted Subsidiaries pursuant to documents relating to any Qualified Securitization Transaction, (ii) all rights arising under the documentation governing or related to receivables (including rights
in respect of Liens securing such receivables and other credit support in respect of such receivables), any proceeds of such receivables and any lockboxes or accounts in which such proceeds are deposited, spread accounts and other similar accounts
(and any amounts on deposit therein) established in connection with a Qualified Securitization Transaction, any warranty, indemnity, dilution and other intercompany claim arising out of the documents relating to such Qualified Securitization
Transaction and other assets which are customarily transferred or in respect of which security interests are customarily granted in connection with asset securitizations involving accounts receivable and (iii) all collections (including
recoveries) and other proceeds of the assets described in the foregoing clauses (i) and (ii). 
 “Securitization Special
Purpose Entity” means a Person (including, without limitation, a Restricted Subsidiary) created in connection with the transactions contemplated by a Qualified Securitization Transaction, which Person engages in no activities and holds no
assets other than those incidental to such Qualified Securitization Transaction. 
 “Senior Indebtedness” means with
respect to any Person: 
 (1) Indebtedness of such Person, whether outstanding on the Issue Date or thereafter Incurred; and

 (2) all other Obligations of such Person (including interest accruing on or after the filing of any petition in bankruptcy
or for reorganization relating to such Person, whether or not post-filing interest is allowed in such proceeding) in respect of Indebtedness described in clause (1) above; 

unless, in the case of clauses (1) and (2), in the instrument creating or evidencing the same or pursuant to which the same is outstanding, it is provided
that such Indebtedness or other obligations are subordinate in right of payment to the Notes or the Note Guarantee of such Person, as the case may be; provided, however, that Senior Indebtedness shall not include: 

 

	 	(A)	any obligation of such Person to the Parent or any Subsidiary; 

  

	 	(B)	any liability for federal, state, local or other taxes owed or owing by such Person; 

  

	 	(C)	any accounts payable or other liability to trade creditors arising in the ordinary course of business; 

  

	 	(D)	any Indebtedness or other Obligation of such Person which is subordinate or junior in any respect to any other Indebtedness or other Obligation of such Person; or 


 

	 	(E)	that portion of any Indebtedness which at the time of Incurrence is Incurred in violation of this Indenture.


“S&P” means Standard & Poor’s Ratings Group, and any successor to its rating agency business. 

  
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 “Significant Subsidiary” means any Restricted Subsidiary that would be a
“significant subsidiary” as defined in Article 1, Rule 1-02 of Regulation S-X under the Securities Act, as such Regulation is in effect on the Issue Date; provided, however, that,
in the case of a subsidiary that meets the criteria of clause (3) of the definition thereof but not clause (1) or (2) thereof, such subsidiary shall be deemed not to be a Significant Subsidiary unless the subsidiary’s income (or
loss) from continuing operations before income taxes, extraordinary items and cumulative effect of a change in accounting principles exclusive of amounts attributable to any non-controlling interests for the last completed fiscal year prior to the
date of such determination exceeds $15.0 million. 
 “Standard Securitization Undertakings” means all representations,
warranties, covenants, indemnities, performance guarantees and servicing obligations entered into by the Parent or any Subsidiary (other than a Securitization Special Purpose Entity) which are customary in connection with any Qualified
Securitization Transaction. 
 “Stated Maturity” means, with respect to any installment of interest or principal on any
series of Indebtedness, the date on which the payment of interest or principal was scheduled to be paid in the documentation governing such Indebtedness as of its date of issue, and will not include any contingent obligations to repay, redeem or
repurchase any such interest or principal prior to the date originally scheduled for the payment thereof. 
 “Subsidiary”
means, with respect to any specified Person: 
 (1) any corporation, association or other business entity of which more than
50% of the total voting power of shares of Capital Stock entitled (without regard to the occurrence of any contingency and after giving effect to any voting agreement or stockholders’ agreement that effectively transfers voting power) to vote
in the election of directors, managers or trustees of the corporation, association or other business entity is at the time owned or controlled, directly or indirectly, by that Person or one or more of the other Subsidiaries of that Person (or a
combination thereof); or 
 (2) any partnership or limited liability company of which (a) more than 50% of the capital
accounts, distribution rights, total equity or economic interests, as applicable, are owned, directly or indirectly, by such Person or one or more of the other Subsidiaries of that Person or a combination thereof, whether in the form of membership,
general, special or limited partnership interests or otherwise, and (b) such Person or any Subsidiary of such Person is a controlling general partner. 

“Tax” means any tax, duty, levy, impost, assessment or other governmental charge (including penalties, interest and any other
liabilities related thereto, and, for the avoidance of doubt, including any withholding or deduction for or on account of any of the foregoing). “Taxes” shall be construed to have a corresponding meaning. 

“Total Assets” means the total assets of the Parent and the Restricted Subsidiaries, as shown on the most recent balance
sheet of the Parent for which internal financial statements are available immediately preceding the date on which any calculation of Total Assets is being made, with such pro forma adjustments for transactions consummated on or prior to or
simultaneously with the date of the calculation as are appropriate and consistent with the pro forma adjustment provisions set forth in the definition of Fixed Charge Coverage Ratio. For the avoidance of doubt, any Indebtedness or Lien
incurred, Investment or Restricted Payment made, or Designated Noncash Consideration received, in each case that was permitted under this Indenture at the time of such incurrence, making or receipt, shall continue to be permitted under this
Indenture, regardless of any subsequent decrease in Total Assets.

  
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 “Transactions” means the transactions contemplated by the Merger Agreement, the
issuance of the Notes, borrowings under the Credit Agreement, the prepayment of certain indebtedness of Raptor and its Subsidiaries and other related transactions. 

“Treasury Management Arrangement” means any agreement or other arrangement governing the provision of treasury or cash
management services, including deposit accounts, overdraft, credit or debit card, funds transfer, automated clearinghouse transfers, zero balance accounts, returned check concentration, controlled disbursement, lockbox, account reconciliation and
reporting, trade finance services and other cash management services. 
 “Treasury Rate” means, as of any redemption date,
as determined by the Parent, the yield to maturity as of such redemption date of United States Treasury securities with a constant maturity (as compiled and published in the most recent Federal Reserve Statistical Release H.15 (519) that has become
publicly available at least two Business Days prior to the redemption date (or, if such Statistical Release is no longer published, any publicly available source of similar market data)) most nearly equal to the period from the redemption date to
November 1, 2019; provided, however, that if the period from the redemption date to November 1, 2019 is less than one year, the weekly average yield on actually traded United States Treasury securities adjusted to a constant
maturity of one year will be used. 
 “Triggering Indebtedness” means (i) the Credit Agreement, (ii) the 2022
Notes, (iii) the 2023 Notes, or (iv) any other Indebtedness of the Parent or any Restricted Subsidiary that is represented by bonds, debentures, notes or other securities and that is guaranteed by any of the Issuers or any Guarantor, in
each case, that has an outstanding principal amount or committed amount of at least $50.0 million. 
 “Trustee” means U.S.
Bank National Association, until a successor replaces it in accordance with the applicable provisions of this Indenture and thereafter means the successor serving hereunder. 

“Unrestricted Definitive Note” means a Definitive Note that does not bear and is not required to bear the Private Placement
Legend. 
 “Unrestricted Global Note” means a Global Note that does not bear and is not required to bear the Private
Placement Legend. 
 “Unrestricted Subsidiary” means (1) any Subsidiary that at the time of determination shall be
designated an Unrestricted Subsidiary by the Board of Directors of the Parent in accordance with Section 4.19, (2) any Subsidiary of an Unrestricted Subsidiary and (3) Andromeda Biotech Ltd. 

“Upfront Payments” means any upfront or similar payments made in connection with any drug or pharmaceutical product research
and development or collaboration arrangements or the closing of any Permitted Investment or other acquisition (including any license or the acquisition of any license) of any rights in respect of any drug or other pharmaceutical product (and any
related property or assets). 
 “U.S. Person” means a U.S. Person as defined in Rule 902(k) promulgated under the
Securities Act. 
 “Voting Stock” of any specified Person as of any date means the Capital Stock of such Person of the
class or classes that has the general voting power under ordinary circumstances to elect at least a majority of the Board of Directors of such Person (irrespective of whether or not at the time Capital Stock of any other class or classes shall have
or might have voting power by reason of the happening of any contingency). 

  
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 “Weighted Average Life to Maturity” means, when applied to any Indebtedness at
any date, the number of years obtained by dividing: 
 (1) the sum of the products obtained by multiplying (a) the amount of
each then remaining installment, sinking fund, serial maturity or other required payments of principal, including payment at final maturity, in respect of the Indebtedness, by (b) the number of years (calculated to the nearest one-twelfth) that will
elapse between such date and the making of such payment; by 
 (2) the then outstanding principal amount of such
Indebtedness. 
 “Wholly-Owned Subsidiary” means a Restricted Subsidiary of which the Parent owns, directly or indirectly,
all of the Capital Stock, other than directors’ qualifying shares, of such Restricted Subsidiary. 
 Section 1.02 Other Definitions. 

 

			
	 Term
	  	 Defined

in

Section

		
	 “Additional Notes” 
	  	2.02
	“Additional Amounts”	  	4.21
	“Affiliate Transaction”	  	4.11
	“Authentication Order”	  	2.02
	“Change of Control Payment”	  	4.14
	“Code”	  	4.21
	“Covenant Defeasance”	  	8.03
	“Designation”	  	4.19
	“DTC”	  	2.03
	“Event of Default”	  	6.01
	“Excess Proceeds”	  	4.10
	“Initial Lien”	  	4.12
	“Legal Defeasance”	  	8.02
	“Offer Amount”	  	3.09
	“Offer Period”	  	3.09
	“Paying Agent”	  	2.03
	“Permitted Debt”	  	4.09
	“Purchase Date”	  	3.09
	“Registrar”	  	2.03
	“Restricted Payments”	  	4.07
	“Revocation”	  	4.19
	“Successor Guarantor”	  	10.04
	“Tax Jurisdiction”	  	4.21
	“Tax Redemption Date”	  	3.10

 Section 1.03 Rules of Construction. 

Unless the context otherwise requires: 

(a) a term has the meaning assigned to it; 

(b) an accounting term not otherwise defined has the meaning assigned to it in accordance with GAAP; 

  
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 (c) “or” is not exclusive; 

(d) words in the singular include the plural, and in the plural include the singular; 

(e) “will” shall be interpreted to express a command; 

(f) provisions apply to successive events and transactions; and 

(g) references to sections of or rules under the Securities Act will be deemed to include substitute, replacement of successor
sections or rules adopted by the SEC from time to time. 
 ARTICLE 2 

THE NOTES 
 Section 2.01 Form and Dating.

 (a) General. The Initial Notes issued on the date hereof will be in an aggregate principal amount of $300,000,000. In
addition, the Issuers may issue, from time to time in accordance with the provisions of this Indenture, Additional Notes. The Notes may have notations, legends or endorsements required by law, stock exchange rule or usage. Each Note will
be dated the date of its authentication. The Notes shall be in denominations of $200,000 and integral multiples of $1,000 in excess of $200,000. 

The terms and provisions contained in the Notes will constitute, and are hereby expressly made, a part of this Indenture and the Issuers, the
Guarantors and the Trustee, by their execution and delivery of this Indenture, expressly agree to such terms and provisions and to be bound thereby. However, to the extent any provision of any Note conflicts with the express provisions of this
Indenture, the provisions of this Indenture shall govern and be controlling. 
 (b) Global Notes. Notes issued in global form
will be substantially in the form of Exhibit A hereto (with the Global Note Legend thereon and the “Schedule of Exchanges of Interests in the Global Note” attached thereto). Notes issued in definitive form will be substantially in the
form of Exhibit A hereto (but without the Global Note Legend thereon and without the “Schedule of Exchanges of Interests in the Global Note” attached thereto). Each Global Note will represent such of the outstanding Notes as will be
specified therein and each shall provide that it represents the aggregate principal amount of outstanding Notes from time to time endorsed thereon and that the aggregate principal amount of outstanding Notes represented thereby may from time to time
be reduced or increased, as appropriate, to reflect exchanges and redemptions. Any endorsement of a Global Note to reflect the amount of any increase or decrease in the aggregate principal amount of outstanding Notes represented thereby will be
made by the Trustee or the Custodian, at the direction of the Trustee, in accordance with instructions given by the Holder thereof as required by Section 2.06 hereof. 

(c) Temporary Global Notes. Notes offered and sold in reliance on Regulation S will be issued initially in the form of the
Regulation S Temporary Global Note, which will be deposited on behalf of the purchasers of the Notes represented thereby with the Trustee, at its New York office, as custodian for the Depositary, and registered in the name of the Depositary or the
nominee of the Depositary for the accounts of designated agents holding on behalf of Euroclear or Clearstream, duly executed by the Issuers and authenticated by the Trustee as hereinafter provided. The Restricted Period will be terminated upon
the receipt by the Trustee of an Officer’s Certificate from the Company. 

  
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 Following the termination of the Restricted Period, beneficial interests in the Regulation S
Temporary Global Note may be exchanged for beneficial interests in the Regulation S Permanent Global Note pursuant to the Applicable Procedures only upon certification that beneficial ownership interests in such Regulation S Temporary Global Notes
are owned by either non-U.S. Persons or U.S. Persons who purchased such interests in a transaction that did not require registration under the Securities Act. The aggregate principal amount of the Regulation S Temporary Global Note and the
Regulation S Permanent Global Note may from time to time be increased or decreased by adjustments made on the records of the Trustee and the Depositary or its nominee, as the case may be, in connection with transfers of interests therein as
hereinafter provided. 
 (d) Euroclear and Clearstream Procedures Applicable. The provisions of the “Operating
Procedures of the Euroclear System” and “Terms and Conditions Governing Use of Euroclear” and the “General Terms and Conditions of Clearstream Banking” and “Customer Handbook” of Clearstream will be applicable to
transfers of beneficial interests in the Regulation S Temporary Global Note and the Regulation S Permanent Global Note that are held by Participants through Euroclear or Clearstream. 

Section 2.02 Execution and Authentication. 

At least one Officer must sign the Notes for the Issuers by manual or facsimile signature.

If an Officer whose signature is on a Note no longer holds that office at the time a Note is authenticated, the Note will nevertheless be
valid. 
 A Note will not be valid until authenticated by the manual signature of the Trustee. The signature will be conclusive
evidence that the Note has been authenticated under this Indenture. 
 The Trustee will, upon receipt of a written order of the Issuers
signed by an Officer of the Issuers (an “Authentication Order”), authenticate Notes in an aggregate principal amount of $300,000,000 for original issue on the Issue Date. The Trustee shall authenticate additional Notes
(“Additional Notes”) thereafter in unlimited aggregate principal amount for original issue upon receipt of an Authentication Order. The aggregate principal amount of Notes outstanding at any time may not exceed the aggregate
principal amount of Notes authorized for issuance by the Issuers pursuant to one or more Authentication Orders, except as provided in Section 2.07 hereof.

The Trustee may appoint an authenticating agent acceptable to the Issuers to authenticate Notes. An authenticating agent may authenticate
Notes whenever the Trustee may do so. Each reference in this Indenture to authentication by the Trustee includes authentication by such agent. An authenticating agent has the same rights as an Agent to deal with Holders or an Affiliate of
the Issuers. 
 Section 2.03 Registrar and Paying Agent. 

The Issuers will maintain an office or agency where Notes may be presented for registration of transfer or for exchange
(“Registrar”) and an office or agency where Notes may be presented for payment (“Paying Agent”) and an office or agency where notices and demands to or upon the Issuers, if any, in respect of the Notes and this
Indenture may be served. The Registrar will keep a register of the Notes and of their transfer and exchange. The Issuers may appoint one or more co-registrars and one or more additional paying agents. The term “Registrar”
includes any co-registrar and the term “Paying Agent” includes any additional paying agent. The Issuers may change any Paying Agent or Registrar without notice to any Holder. The Issuers will notify the Trustee in writing of the
name and address of any Agent not a party to this Indenture. If the Issuers fail to appoint or maintain another entity as Registrar or Paying Agent, the Trustee shall act as such. The Issuers or any of their respective Subsidiaries may act
as Paying Agent or Registrar. 

  
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 The Issuers initially appoint The Depository Trust Company (“DTC”) to act as
Depositary with respect to the Global Notes. 
 The Issuers initially appoint the Trustee to act as the Registrar, Paying Agent and Agent
for service of notices and demands in connection with the Notes and this Indenture, and to act as Custodian with respect to the Global Notes. 
 Section
2.04 Paying Agent to Hold Money in Trust. 
 The Issuers will require each Paying Agent other than the Trustee to agree in writing
that the Paying Agent will hold in trust for the benefit of Holders or the Trustee all money held by the Paying Agent for the payment of principal of, premium on, if any, or interest on, the Notes, and will notify the Trustee in writing of any
default by the Issuers in making any such payment. While any such default continues, the Trustee may require a Paying Agent to pay all money held by it to the Trustee. The Issuers at any time may require a Paying Agent to pay all money
held by it to the Trustee. Upon payment over to the Trustee, the Paying Agent (if other than the Issuers or any of their respective Subsidiaries) will have no further liability for the money. If the Issuers or a Subsidiary acts as Paying
Agent, it will segregate and hold in a separate trust fund for the benefit of the Holders all money held by it as Paying Agent. Upon any bankruptcy or reorganization proceedings relating to the Issuers, the Trustee will serve as Paying Agent
for the Notes. 
 Section 2.05 Holder Lists. 

The Trustee will preserve in as current a form as is reasonably practicable the most recent list available to it of the names and addresses of
all Holders. If the Trustee is not the Registrar, the Issuers will furnish to the Trustee at least seven Business Days before each interest payment date and at such other times as the Trustee may request in writing, a list in such form and as
of such date as the Trustee may reasonably require of the names and addresses of the Holders of Notes. 
 Section 2.06 Transfer and Exchange. 

(a) Transfer and Exchange of Global Notes. A Global Note may not be transferred except as a whole by the Depositary to a nominee
of the Depositary, by a nominee of the Depositary to the Depositary or to another nominee of the Depositary, or by the Depositary or any such nominee to a successor Depositary or a nominee of such successor Depositary. All Global Notes will be
exchanged by the Issuers for Definitive Notes if: 
 (1) the Issuers deliver to the Trustee notice from the Depositary that
it is unwilling or unable to continue to act as Depositary or that it is no longer a clearing agency registered under the Exchange Act and, in either case, a successor Depositary is not appointed by the Issuers within 90 days after the date of such
notice from the Depositary; 
 (2) the Issuers, at their option, notify the Trustee that they elect to cause the issuance of
certificated notes; or 
 (3) there has occurred and is continuing a Default or Event of Default with respect to the Notes
and the Trustee has received a request from the Depositary. 

  
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 Upon the occurrence of either of the preceding events in (1) or (2) above, Definitive Notes shall
be issued in such names as the Depositary shall instruct the Trustee in writing. Global Notes also may be exchanged or replaced, in whole or in part, as provided in Sections 2.07 and 2.10 hereof. Every Note authenticated and delivered in
exchange for, or in lieu of, a Global Note or any portion thereof, pursuant to this Section 2.06 or Section 2.07 or 2.10 hereof, shall be authenticated and delivered in the form of, and shall be, a Global Note. A Global Note may not be
exchanged for another Note other than as provided in this Section 2.06(a), however, beneficial interests in a Global Note may be transferred and exchanged as provided in Section 2.06(b) or (c) hereof.

Notwithstanding the foregoing, in no event shall the Regulation S Temporary Global Note be exchanged by the Issuers for Definitive Notes prior
to (A) the expiration of the Restricted Period and (B) the receipt by the Registrar of any certificates required pursuant to Rule 903(b)(3)(ii)(B) under the Securities Act. 

(b) Transfer and Exchange of Beneficial Interests in the Global Notes. The transfer and exchange of beneficial interests in the
Global Notes will be effected through the Depositary, in accordance with the provisions of this Indenture and the Applicable Procedures. Beneficial interests in the Restricted Global Notes will be subject to restrictions on transfer comparable
to those set forth herein to the extent required by the Securities Act. Transfers of beneficial interests in the Global Notes also will require compliance with either subparagraph (1) or (2) below, as applicable, as well as one or more of the
other following subparagraphs, as applicable: 
 (1) Transfer of Beneficial Interests in the Same Global
Note. Beneficial interests in any Restricted Global Note may be transferred to Persons who take delivery thereof in the form of a beneficial interest in the same Restricted Global Note in accordance with the transfer restrictions set forth
in the Private Placement Legend applicable to such Restricted Global Note. Beneficial interests in any Unrestricted Global Note may be transferred to Persons who take delivery thereof in the form of a beneficial interest in an Unrestricted
Global Note. No written orders or instructions shall be required to be delivered to the Registrar to effect the transfers described in this Section 2.06(b)(1). 

(2) All Other Transfers and Exchanges of Beneficial Interests in Global Notes. In connection with all transfers and
exchanges of beneficial interests that are not subject to Section 2.06(b)(1) above, the transferor of such beneficial interest must deliver to the Registrar either: 

(A) both: 

(i) a written order from a Participant or an Indirect Participant given to the Depositary in accordance with the Applicable
Procedures directing the Depositary to credit or cause to be credited a beneficial interest in another Global Note in an amount equal to the beneficial interest to be transferred or exchanged; and 

(ii) written instructions given in accordance with the Applicable Procedures containing information regarding the Participant
account to be credited with such increase; or 
 (B) both: 

(i) a written order from a Participant or an Indirect Participant given to the Depositary in accordance with the Applicable
Procedures directing the Depositary to cause to be issued a Definitive Note in an amount equal to the beneficial interest to be transferred or exchanged; and 

(ii) instructions given by the Depositary to the Registrar containing information regarding the Person in whose name such
Definitive Note shall be registered to effect the transfer or exchange referred to in (1) above except in compliance with Section 2.06(a) above. 

  
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 Upon satisfaction of all of the requirements for transfer of beneficial interests in Global Notes contained in
this Indenture and the Notes or otherwise applicable under the Securities Act, the Trustee shall adjust the principal amount of the relevant Global Note(s) pursuant to Section 2.06(g) hereof. 

(3) Transfer of Beneficial Interests to Another Restricted Global Note. A beneficial interest in any Restricted
Global Note may be transferred to a Person who takes delivery thereof in the form of a beneficial interest in another Restricted Global Note if the transfer complies with the requirements of Section 2.06(b)(2) above and the Registrar receives the
following: 
 (A) if the transferee will take delivery in the form of a beneficial interest in the 144A Global Note, then the
transferor must deliver a certificate in the form of Exhibit B hereto, including the certifications in item (1) thereof; 

(B) if the transferee will take delivery in the form of a beneficial interest in the Regulation S Temporary Global Note or the
Regulation S Permanent Global Note, then the transferor must deliver a certificate in the form of Exhibit B hereto, including the certifications in item (2) thereof; and 

(C) if the transferee will take delivery in the form of a beneficial interest in the IAI Global Note, then the transferor must
deliver a certificate in the form of Exhibit B hereto, including the certifications, certificates and Opinion of Counsel required by item (3) thereof, if applicable; provided that in each case, if the requested transfer involves a beneficial
interest in a Regulation S Temporary Global Note, such transfer may be effected only upon (A) the expiration of the Restricted Period and (B) the receipt by the Registrar of any certificates required pursuant to Rule 903(b)(3)(ii)(B) under the
Securities Act. 
 (4) Transfer and Exchange of Beneficial Interests in a Restricted Global Note for Beneficial Interests in
an Unrestricted Global Note. A beneficial interest in any Restricted Global Note may be exchanged by any holder thereof for a beneficial interest in an Unrestricted Global Note or transferred to a Person who takes delivery thereof in the form
of a beneficial interest in an Unrestricted Global Note if the exchange or transfer complies with the requirements of Section 2.06(b)(2) above if the Registrar receives the following: 

(A) if the holder of such beneficial interest in a Restricted Global Note proposes to exchange such beneficial interest for a
beneficial interest in an Unrestricted Global Note, a certificate from such holder in the form of Exhibit C hereto, including the certifications in item (1)(a) thereof; or 

(B) if the holder of such beneficial interest in a Restricted Global Note proposes to transfer such beneficial interest to a
Person who shall take delivery thereof in the form of a beneficial interest in an Unrestricted Global Note, a certificate from such holder in the form of Exhibit B hereto, including the certifications in item (4) thereof; 

  
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 and, in each such case set forth in this subparagraph (4), if the Registrar so requests or if the
Applicable Procedures so require, an Opinion of Counsel in form reasonably acceptable to the Registrar to the effect that such exchange or transfer is in compliance with the Securities Act and that the restrictions on transfer contained herein and
in the Private Placement Legend are no longer required in order to maintain compliance with the Securities Act. 
 If any such transfer is
effected pursuant to subparagraph (4) above at a time when an Unrestricted Global Note has not yet been issued, the Issuers shall issue and, upon receipt of an Authentication Order in accordance with Section 2.02 hereof, the Trustee shall
authenticate one or more Unrestricted Global Notes in an aggregate principal amount equal to the aggregate principal amount of beneficial interests transferred pursuant to subparagraph (4) above. 

Beneficial interests in an Unrestricted Global Note cannot be exchanged for, or transferred to Persons who take delivery thereof in the form
of, a beneficial interest in a Restricted Global Note. 
 (c) Transfer or Exchange of Beneficial Interests for Definitive Notes. 

(1) Beneficial Interests in Restricted Global Notes to Restricted Definitive Notes. If, in accordance with Section
2.06(a), any holder of a beneficial interest in a Restricted Global Note proposes to exchange such beneficial interest for a Restricted Definitive Note or to transfer such beneficial interest to a Person who takes delivery thereof in the form of a
Restricted Definitive Note, then, upon receipt by the Registrar of the following documentation: 
 (A) if the holder of such
beneficial interest in a Restricted Global Note proposes to exchange such beneficial interest for a Restricted Definitive Note, a certificate from such holder in the form of Exhibit C hereto, including the certifications in item (2)(a) thereof; 

(B) if such beneficial interest is being transferred to a QIB in accordance with Rule 144A, a certificate to the effect set
forth in Exhibit B hereto, including the certifications in item (1) thereof; 
 (C) if such beneficial interest is being
transferred to a Non-U.S. Person in an offshore transaction in accordance with Rule 903 or Rule 904, a certificate to the effect set forth in Exhibit B hereto, including the certifications in item (2) thereof; 

(D) if such beneficial interest is being transferred pursuant to an exemption from the registration requirements of the
Securities Act in accordance with Rule 144, a certificate to the effect set forth in Exhibit B hereto, including the certifications in item (3)(a) thereof; 

(E) if such beneficial interest is being transferred to an Institutional Accredited Investor in reliance on an exemption from
the registration requirements of the Securities Act other than those listed in subparagraphs (B) through (D) above, a certificate to the effect set forth in Exhibit B hereto, including the certifications, certificates and Opinion of Counsel required
by item (3) thereof, if applicable; 
 (F) if such beneficial interest is being transferred to the Company or any of its
Subsidiaries, a certificate to the effect set forth in Exhibit B hereto, including the certifications in item (3)(b) thereof; or 

(G) if such beneficial interest is being transferred pursuant to an effective registration statement under the Securities Act,
a certificate to the effect set forth in Exhibit B hereto, including the certifications in item (3)(c) thereof, 

  
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 the Trustee shall cause the aggregate principal amount of the applicable Global Note to be reduced accordingly
pursuant to Section 2.06(g) hereof, and the Issuers shall execute and the Trustee shall authenticate and deliver to the Person designated in the instructions a Definitive Note in the appropriate principal amount. Any Definitive Note issued
in exchange for a beneficial interest in a Restricted Global Note pursuant to this Section 2.06(c) shall be registered in such name or names and in such authorized denomination or denominations as the holder of such beneficial interest shall
instruct the Registrar through instructions from the Depositary and the Participant or Indirect Participant. The Trustee shall deliver such Definitive Notes to the Persons in whose names such Notes are so registered. Any Definitive Note issued in
exchange for a beneficial interest in a Restricted Global Note pursuant to this Section 2.06(c)(1) shall bear the Private Placement Legend and shall be subject to all restrictions on transfer contained therein. 

(2) Beneficial Interests in Regulation S Temporary Global Note to Definitive Notes. Notwithstanding
Sections 2.06(c)(1) hereof, a beneficial interest in the Regulation S Temporary Global Note may not be exchanged for a Definitive Note or transferred to a Person who takes delivery thereof in the form of a Definitive Note prior to (A) the
expiration of the Restricted Period and (B) the receipt by the Registrar of any certificates required pursuant to Rule 903(b)(3)(ii)(B) under the Securities Act. 

(3) Beneficial Interests in Restricted Global Notes to Unrestricted Definitive Notes. Subject to
Section 2.06(a), a holder of a beneficial interest in a Restricted Global Note may exchange such beneficial interest for an Unrestricted Definitive Note or may transfer such beneficial interest to a Person who takes delivery thereof in the form
of an Unrestricted Definitive Note only if the Registrar receives the following: 
 (A) if the holder of such beneficial
interest in a Restricted Global Note proposes to exchange such beneficial interest for an Unrestricted Definitive Note, a certificate from such holder in the form of Exhibit C hereto, including the certifications in item (1)(b) thereof; or 

(B) if the holder of such beneficial interest in a Restricted Global Note proposes to transfer such beneficial interest to a
Person who shall take delivery thereof in the form of an Unrestricted Definitive Note, a certificate from such holder in the form of Exhibit B hereto, including the certifications in item (4) thereof; 

and, in each such case set forth in this subparagraph (3), if the Registrar or the Issuers so request or if the Applicable Procedures so
require, an Opinion of Counsel in form reasonably acceptable to the Registrar to the effect that such exchange or transfer is in compliance with the Securities Act and that the restrictions on transfer contained herein and in the Private Placement
Legend are no longer required in order to maintain compliance with the Securities Act. 
 (4) Beneficial Interests in
Unrestricted Global Notes to Unrestricted Definitive Notes. Subject to Section 2.06(a), if any holder of a beneficial interest in an Unrestricted Global Note proposes to exchange such beneficial interest for a Definitive Note or to
transfer such beneficial interest to a Person who takes delivery thereof in the form of a Definitive Note, then, upon satisfaction of the conditions set forth in Section 2.06(b)(2) hereof, the Trustee will cause the aggregate principal amount
of the applicable Global Note to be reduced accordingly pursuant 

  
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to Section 2.06(g) hereof, and the Issuers will execute and the Trustee will authenticate and deliver to the Person designated in the instructions a Definitive Note in the appropriate
principal amount. Any Definitive Note issued in exchange for a beneficial interest pursuant to this Section 2.06(c)(4) will be registered in such name or names and in such authorized denomination or denominations as the holder of such beneficial
interest requests through instructions to the Registrar from or through the Depositary and the Participant or Indirect Participant. The Trustee will deliver such Definitive Notes to the Persons in whose names such Notes are so
registered. Any Definitive Note issued in exchange for a beneficial interest pursuant to this Section 2.06(c)(4) will not bear the Private Placement Legend. 

(d) Transfer and Exchange of Definitive Notes for Beneficial Interests. 

(1) Restricted Definitive Notes to Beneficial Interests in Restricted Global Notes. If any Holder of a Restricted
Definitive Note proposes to exchange such Note for a beneficial interest in a Restricted Global Note or to transfer such Restricted Definitive Notes to a Person who takes delivery thereof in the form of a beneficial interest in a Restricted Global
Note, then, upon receipt by the Registrar of the following documentation: 
 (A) if the Holder of such Restricted Definitive
Note proposes to exchange such Note for a beneficial interest in a Restricted Global Note, a certificate from such Holder in the form of Exhibit C hereto, including the certifications in item (2)(b) thereof; 

(B) if such Restricted Definitive Note is being transferred to a QIB in accordance with Rule 144A, a certificate to the effect
set forth in Exhibit B hereto, including the certifications in item (1) thereof; 
 (C) if such Restricted Definitive Note is
being transferred to a Non-U.S. Person in an offshore transaction in accordance with Rule 903 or Rule 904, a certificate to the effect set forth in Exhibit B hereto, including the certifications in item (2) thereof; 

(D) if such Restricted Definitive Note is being transferred pursuant to an exemption from the registration requirements of the
Securities Act in accordance with Rule 144, a certificate to the effect set forth in Exhibit B hereto, including the certifications in item (3)(a) thereof; 

(E) if such Restricted Definitive Note is being transferred to an Institutional Accredited Investor in reliance on an exemption
from the registration requirements of the Securities Act other than those listed in subparagraphs (B) through (D) above, a certificate to the effect set forth in Exhibit B hereto, including the certifications, certificates and Opinion of Counsel
required by item (3) thereof, if applicable; 
 (F) if such Restricted Definitive Note is being transferred to the Company or
any of its Subsidiaries, a certificate to the effect set forth in Exhibit B hereto, including the certifications in item (3)(b) thereof; or 

(G) if such Restricted Definitive Note is being transferred pursuant to an effective registration statement under the
Securities Act, a certificate to the effect set forth in Exhibit B hereto, including the certifications in item (3)(c) thereof, 
 the
Trustee will cancel the Restricted Definitive Note, increase or cause to be increased the aggregate principal amount of, in the case of clause (A) above, the appropriate 

  
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Restricted Global Note, in the case of clause (B) above, the 144A Global Note, in the case of clause (C) above, the Regulation S Global Note, and in all other cases, the IAI Global Note. 

(2) Restricted Definitive Notes to Beneficial Interests in Unrestricted Global Notes. A Holder of a Restricted
Definitive Note may exchange such Note for a beneficial interest in an Unrestricted Global Note or transfer such Restricted Definitive Note to a Person who takes delivery thereof in the form of a beneficial interest in an Unrestricted Global Note
only if the Registrar receives the following:
 (A) if the Holder of such Definitive Notes proposes to exchange such Notes
for a beneficial interest in the Unrestricted Global Note, a certificate from such Holder in the form of Exhibit C hereto, including the certifications in item (1)(c) thereof; or 

(B) if the Holder of such Definitive Notes proposes to transfer such Notes to a Person who shall take delivery thereof in the
form of a beneficial interest in the Unrestricted Global Note, a certificate from such Holder in the form of Exhibit B hereto, including the certifications in item (4) thereof; 

and, in each such case set forth in this subparagraph (2), if the Registrar or the Issuers so request or if the Applicable Procedures so
require, an Opinion of Counsel in form reasonably acceptable to the Registrar to the effect that such exchange or transfer is in compliance with the Securities Act and that the restrictions on transfer contained herein and in the Private Placement
Legend are no longer required in order to maintain compliance with the Securities Act. 
 Upon satisfaction of the conditions
of any of the subparagraphs in this Section 2.06(d)(2), the Trustee will cancel the Definitive Notes and increase or cause to be increased the aggregate principal amount of the Unrestricted Global Note. 

(3) Unrestricted Definitive Notes to Beneficial Interests in Unrestricted Global Notes. A Holder of an Unrestricted
Definitive Note may exchange such Note for a beneficial interest in an Unrestricted Global Note or transfer such Definitive Notes to a Person who takes delivery thereof in the form of a beneficial interest in an Unrestricted Global Note at any time.
Upon receipt of a request for such an exchange or transfer, the Trustee will cancel the applicable Unrestricted Definitive Note and increase or cause to be increased the aggregate principal amount of one of the Unrestricted Global Notes. 

If any such exchange or transfer from a Definitive Note to a beneficial interest is effected pursuant to subparagraph (2)(B) or
(3) above at a time when an Unrestricted Global Note has not yet been issued, the Issuers will issue and, upon receipt of an Authentication Order in accordance with Section 2.02 hereof, the Trustee will authenticate one or more Unrestricted Global
Notes in an aggregate principal amount equal to the principal amount of Definitive Notes so transferred. 

  
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 (e) Transfer and Exchange of Definitive Notes for Definitive Notes. Upon request by a
Holder of Definitive Notes and such Holder’s compliance with the provisions of this Section 2.06(e), the Registrar will register the transfer or exchange of Definitive Notes. Prior to such registration of transfer or exchange, the requesting
Holder must present or surrender to the Registrar the Definitive Notes duly endorsed or accompanied by a written instruction of transfer in form satisfactory to the Registrar duly executed by such Holder or by its attorney, duly authorized in
writing. In addition, the requesting Holder must provide any additional certifications, documents and information, as applicable, required pursuant to the following provisions of this Section 2.06(e). 

(1) Restricted Definitive Notes to Restricted Definitive Notes. Any Restricted Definitive Note may be transferred
to and registered in the name of Persons who take delivery thereof in the form of a Restricted Definitive Note if the Registrar receives the following: 

(A) if the transfer will be made pursuant to Rule 144A, then the transferor must deliver a certificate in the form of Exhibit B
hereto, including the certifications in item (1) thereof; 
 (B) if the transfer will be made pursuant to Rule 903 or Rule
904, then the transferor must deliver a certificate in the form of Exhibit B hereto, including the certifications in item (2) thereof; and 

(C) if the transfer will be made pursuant to any other exemption from the registration requirements of the Securities Act, then
the transferor must deliver a certificate in the form of Exhibit B hereto, including the certifications, certificates and Opinion of Counsel required by item (3) thereof, if applicable. 

(2) Restricted Definitive Notes to Unrestricted Definitive Notes. Any Restricted Definitive Note may be exchanged
by the Holder thereof for an Unrestricted Definitive Note or transferred to a Person or Persons who take delivery thereof in the form of an Unrestricted Definitive Note if the Registrar receives the following: 

(A) if the Holder of such Restricted Definitive Notes proposes to exchange such Notes for an Unrestricted Definitive Note, a
certificate from such Holder in the form of Exhibit C hereto, including the certifications in item (1)(d) thereof; or 
 (B)
if the Holder of such Restricted Definitive Notes proposes to transfer such Notes to a Person who shall take delivery thereof in the form of an Unrestricted Definitive Note, a certificate from such Holder in the form of Exhibit B hereto,
including the certifications in item (4) thereof; 
 and, in each such case set forth in this subparagraph (2), if the Registrar or the
Issuers so request, an Opinion of Counsel in form reasonably acceptable to the Registrar to the effect that such exchange or transfer is in compliance with the Securities Act and that the restrictions on transfer contained herein and in the Private
Placement Legend are no longer required in order to maintain compliance with the Securities Act. 
 (3) Unrestricted
Definitive Notes to Unrestricted Definitive Notes. A Holder of Unrestricted Definitive Notes may transfer such Notes to a Person who takes delivery thereof in the form of an Unrestricted Definitive Note. Upon receipt of a request to
register such a transfer, the Registrar shall register the Unrestricted Definitive Notes pursuant to the instructions from the Holder thereof. 

  
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 (f) Legends. The following legends will appear on the face of all Global Notes and
Definitive Notes issued under this Indenture unless specifically stated otherwise in the applicable provisions of this Indenture. 

(1) Private Placement Legend. 

(A) Except as permitted by subparagraph (B) or (C) below, each Global Note and each Definitive Note (and all Notes issued in
exchange therefor or substitution thereof) shall bear the legend in substantially the following form: 
 “THIS SECURITY HAS NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ‘‘SECURITIES ACT’’), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION. NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN MAY BE REOFFERED, SOLD,
ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH REGISTRATION OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, SUCH REGISTRATION. THE HOLDER OF THIS SECURITY, BY ITS ACCEPTANCE HEREOF, AGREES ON
ITS OWN BEHALF AND ON BEHALF OF ANY INVESTOR ACCOUNT FOR WHICH IT HAS PURCHASED SECURITIES, TO OFFER, SELL OR OTHERWISE TRANSFER SUCH SECURITY, PRIOR TO THE DATE (THE ‘‘RESALE RESTRICTION TERMINATION DATE’’) THAT IS [IN THE CASE
OF RULE 144A NOTES: ONE YEAR] [IN THE CASE OF REGULATION S NOTES: 40 DAYS] AFTER THE LATER OF THE ORIGINAL ISSUE DATE HEREOF AND THE LAST DATE ON WHICH THE COMPANY OR ANY AFFILIATE OF THE COMPANY WAS THE OWNER OF THIS SECURITY (OR ANY PREDECESSOR OF
SUCH SECURITY), ONLY (A) TO THE COMPANY, (B) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT, (C) FOR SO LONG AS THE SECURITIES ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A UNDER
THE SECURITIES ACT, TO A PERSON IT REASONABLY BELIEVES IS A ‘‘QUALIFIED INSTITUTIONAL BUYER’’ AS DEFINED IN RULE 144A UNDER THE SECURITIES ACT THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE ACCOUNT OF A QUALIFIED INSTITUTIONAL
BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER IS BEING MADE IN RELIANCE ON RULE 144A, (D) PURSUANT TO OFFERS AND SALES THAT OCCUR OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES ACT, OR (E) PURSUANT TO
ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO THE COMPANY’S AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER PURSUANT TO CLAUSES (D) OR (E) TO REQUIRE THE
DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF THEM. [IN THE CASE OF REGULATION S NOTES: BY ITS ACQUISITION HEREOF, THE HOLDER HEREOF REPRESENTS THAT IT IS NOT A U.S. PERSON NOR IS IT
PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THIS SECURITY IN AN OFFSHORE TRANSACTION IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.]” 

(B) Notwithstanding the foregoing, any Global Note or Definitive Note issued pursuant to subparagraph (b)(4), (c)(3), (c)(4),
(d)(2), (d)(3), (e)(2) or (e)(3) of this Section 2.06 (and all Notes issued in exchange therefor or substitution thereof) will not bear the Private Placement Legend. 

  
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 (C) The Issuers may cause the removal of the Private Placement Legend from a
Global Note at any time on or after the 366th day after the date hereof through the mandatory exchange procedures of the Depositary by delivery to the Depositary an instruction letter for the
Depositary’s mandatory exchange process (and/or otherwise complying with any Applicable Procedures). Until such time as the Issuers provide such instruction letter to the Depositary notifying and confirming to the Depositary that the restricted
period for the Notes represented by such Global Note has elapsed and instructing the Depositary to exchange all “restricted securities” represented by a restricted CUSIP for “unrestricted securities” represented by an
unrestricted CUSIP (and/or otherwise complies with the Applicable Procedures) and the Depositary moves the Notes represented by such Global Note from a restricted CUSIP number to an unrestricted CUSIP number in accordance with its Applicable
Procedures, the restricted CUSIP will be the CUSIP number for such Notes. At such time as the Issuers provide such instruction letter to the Depositary (and/or otherwise complies with the Applicable Procedures) and the Depositary has moved all
of such Notes represented by a restricted CUSIP number to an unrestricted CUSIP number, the Private Placement Legend will be deemed removed from such Global Note and an unrestricted CUSIP number for such Notes will be deemed to be the CUSIP number
for such Notes. Thereafter such Global Notes shall be deemed an Unrestricted Global Note. No Opinion of Counsel shall be required to be delivered in connection with the mandatory exchange process under this clause (C) and the removal of the
Private Placement Legend; provided, however, the Trustee may rely on an Officer’s Certificate from the Issuers as sufficient evidence of the existence and satisfaction of the conditions as described above. 

(2) Global Note Legend. Each Global Note will bear a legend in substantially the following form: 

“THIS GLOBAL NOTE IS HELD BY THE DEPOSITARY (AS DEFINED IN THE INDENTURE GOVERNING THIS NOTE) OR ITS NOMINEE IN CUSTODY FOR THE BENEFIT OF
THE BENEFICIAL OWNERS HEREOF, AND IS NOT TRANSFERABLE TO ANY PERSON UNDER ANY CIRCUMSTANCES EXCEPT THAT (1) THE TRUSTEE MAY MAKE SUCH NOTATIONS HEREON AS MAY BE REQUIRED PURSUANT TO SECTION 2.06 OF THE INDENTURE, (2) THIS GLOBAL NOTE MAY BE
EXCHANGED IN WHOLE BUT NOT IN PART PURSUANT TO SECTION 2.06(A) OF THE INDENTURE, (3) THIS GLOBAL NOTE MAY BE DELIVERED TO THE TRUSTEE FOR CANCELLATION PURSUANT TO SECTION 2.11 OF THE INDENTURE AND (4) THIS GLOBAL NOTE MAY BE TRANSFERRED TO A
SUCCESSOR DEPOSITARY WITH THE PRIOR WRITTEN CONSENT OF THE ISSUERS. 
 UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR NOTES IN
DEFINITIVE FORM, THIS NOTE MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE DEPOSITARY OR BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE DEPOSITARY OR BY THE DEPOSITARY OR ANY SUCH NOMINEE TO
A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR DEPOSITARY. UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (55 WATER STREET, NEW YORK, NEW YORK) (“DTC”), TO THE ISSUERS OR
THEIR AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME 

  
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OF CEDE & CO. OR SUCH OTHER NAME AS MAY BE REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR SUCH OTHER ENTITY AS MAY BE REQUESTED BY AN
AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 

BY ITS ACQUISITION OF THIS SECURITY, THE HOLDER THEREOF WILL BE DEEMED TO HAVE REPRESENTED AND WARRANTED THAT EITHER (1) SUCH HOLDER IS NOT
PURCHASING OR HOLDING THIS SECURITY WITH THE ASSETS OF (A) AN EMPLOYEE BENEFIT PLAN (AS DEFINED IN SECTION 3(3) OF THE EMPLOYEE RETIREMENT INCOME SECURITY ACT OF 1974, AS AMENDED (“ERISA”)) THAT IS SUBJECT TO TITLE I OF ERISA, (B) A
“PLAN” THAT IS SUBJECT TO SECTION 4975 OF THE U.S. INTERNAL REVENUE CODE OF 1986, AS AMENDED (THE “CODE”), (C) AN ENTITY DEEMED UNDER ERISA TO HOLD “PLAN ASSETS” OF ANY OF THE FOREGOING BY REASON OF AN EMPLOYEE BENEFIT
PLAN OR PLAN’S INVESTMENT IN SUCH ENTITY, OR (D) A GOVERNMENTAL PLAN, CHURCH PLAN OR NON-U.S. PLAN SUBJECT TO PROVISIONS UNDER ANY FEDERAL, STATE, LOCAL, NON-U.S. OR OTHER LAWS OR REGULATIONS THAT ARE SIMILAR TO THE FOREGOING PROVISIONS OF
ERISA OR THE CODE (“SIMILAR LAW”), OR (2) THE PURCHASE AND HOLDING OF THIS SECURITY WILL NOT CONSTITUTE OR RESULT IN A NON-EXEMPT PROHIBITED TRANSACTION UNDER SECTION 406 OF ERISA OR SECTION 4975 OF THE CODE OR A SIMILAR VIOLATION
UNDER ANY APPLICABLE SIMILAR LAWS.” 
 (3) Regulation S Temporary Global Note Legend. The Regulation S
Temporary Global Note will bear a legend in substantially the following form: 
 “BENEFICIAL OWNERSHIP INTERESTS IN THIS REGULATION S
TEMPORARY GLOBAL NOTE WILL NOT BE EXCHANGEABLE FOR INTERESTS IN THE REGULATION S PERMANENT GLOBAL NOTE OR ANY OTHER NOTE, UNTIL THE EXPIRATION OF THE 40-DAY DISTRIBUTION COMPLIANCE PERIOD (WITHIN THE MEANING OF RULE 903(b)(3) OF REGULATION S UNDER
THE SECURITIES ACT) AND THEN ONLY UPON CERTIFICATION IN FORM REASONABLY SATISFACTORY TO THE TRUSTEE THAT SUCH BENEFICIAL INTERESTS ARE OWNED EITHER BY NON U.S. PERSONS OR U.S. PERSONS WHO PURCHASED SUCH INTERESTS IN A TRANSACTION THAT DID NOT
REQUIRE REGISTRATION UNDER THE SECURITIES ACT.” 
 (g) Cancellation and/or Adjustment of Global Notes. At such time as all
beneficial interests in a particular Global Note have been exchanged for Definitive Notes or a particular Global Note has been redeemed, repurchased or canceled in whole and not in part, each such Global Note will be returned to or retained and
canceled by the Trustee in accordance with Section 2.11 hereof. At any time prior to such cancellation, if any beneficial interest in a Global Note is exchanged for or transferred to a Person who will take delivery thereof in the form of a
beneficial interest in another Global Note or for Definitive Notes, the principal amount of Notes represented by such Global Note will be reduced accordingly and an endorsement will be made on such Global Note by the Trustee or by the Depositary at
the direction of the Trustee to reflect such reduction; and if the beneficial interest is being exchanged for or transferred to a Person who will take delivery thereof in the form of a beneficial interest in another Global Note, such other Global
Note will be increased accordingly and an endorsement will be made on such Global Note by the Trustee or by the Depositary at the direction of the Trustee to reflect such increase. 

  
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 (h) General Provisions Relating to Transfers and Exchanges. 

(1) To permit registrations of transfers and exchanges, the Issuers will execute and the Trustee will authenticate Global Notes
and Definitive Notes upon receipt of an Authentication Order in accordance with Section 2.02 hereof or at the Registrar’s request. 

(2) No service charge will be made to a Holder of a beneficial interest in a Global Note or to a Holder of a Definitive Note
for any registration of transfer or exchange, but the Issuers may require payment of a sum sufficient to cover any transfer tax or similar governmental charge payable in connection therewith (other than any such transfer taxes or similar
governmental charge payable upon exchange or transfer pursuant to Sections 2.10, 3.06, 3.09, 4.10, 4.14 and 9.05 hereof). 

(3) The Registrar will not be required to register the transfer of or exchange of any Note selected for redemption in whole or
in part, except the unredeemed portion of any Note being redeemed in part. 
 (4) All Global Notes and Definitive Notes
issued upon any registration of transfer or exchange of Global Notes or Definitive Notes will be the valid obligations of the Issuers, evidencing the same debt, and entitled to the same benefits under this Indenture, as the Global Notes or
Definitive Notes surrendered upon such registration of transfer or exchange. 
 (5) Neither the Registrar nor the Issuers
will be required: 
 (A) to issue, to register the transfer of or to exchange any Notes during a period beginning at the
opening of business 15 days before the day of delivering any notice of redemption under Section 3.03 hereof and ending at the close of business on the day of such delivery; 

(B) to register the transfer of or to exchange any Note selected for redemption in whole or in part, except the unredeemed
portion of any Note being redeemed in part; or 
 (C) to register the transfer of or to exchange a Note between a record date
and the next succeeding interest payment date. 
 (6) Prior to due presentment for the registration of a transfer of any
Note, the Trustee, any Agent and the Issuers may deem and treat the Person in whose name any Note is registered as the absolute owner of such Note for the purpose of receiving payment of principal of and interest on such Notes and for all other
purposes, and none of the Trustee, any Agent or the Issuers shall be affected by notice to the contrary. 
 (7) The Trustee
will authenticate Global Notes and Definitive Notes in accordance with the provisions of Section 2.02 hereof. 
 (8) All
certifications, certificates and Opinions of Counsel required to be submitted to the Registrar pursuant to this Section 2.06 to effect a registration of transfer or exchange may be submitted by facsimile. 

  
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 The Trustee shall have no obligation or duty to monitor, determine or inquire as to compliance
with any restrictions on transfer imposed under this Indenture or under applicable law with respect to any transfer of any interest in any Note (including any transfers between or among any participants of the Depositary or beneficial owners of
interests in any Global Notes) other than to require delivery of such certificates and other documentation or evidence as are expressly required by, and to do so if and when expressly required by the terms of, this Indenture, and to examine the same
to determine substantial compliance as to form with the express requirements hereof. 
 Neither the Trustee nor any Agent shall have any
responsibility for any actions taken or not taken by the Depositary. None of the Trustee, any Paying Agent, Transfer Agent or Registrar shall have any responsibility or liability for any acts or omissions of any Depositary with respect to such
global Note, for the records of any Depositary, including records in respect of beneficial ownership interests in respect of any such global Note, for any transactions between such depositary and any participant in such Depositary or between or
among any such Depositary, any such participant and/or any holder or owner of a beneficial interest in such global Note or for any transfers of beneficial interests in any such global Note.

Section 2.07 Replacement Notes. 
 If any
mutilated Note is surrendered to the Trustee or the Issuers and the Trustee receives evidence to its satisfaction of the destruction, loss or theft of any Note, the Issuers will issue and the Trustee, upon receipt of an Authentication Order, will
authenticate a replacement Note if the Trustee’s requirements are met. Upon written request for replacement of a Note by a Holder, the Trustee and the Issuers shall receive an indemnity bond sufficient in the judgment of the Trustee and
the Issuers to protect the Issuers, the Trustee, any Agent and any authenticating agent from any loss that any of them may suffer if a Note is replaced. The Issuers may charge the Holder for their expenses in replacing a Note, with any expense
of the Trustee to be reimbursed in accordance with the terms of this Indenture. 
 Every replacement Note is an additional obligation of the
Issuers and will be entitled to all of the benefits of this Indenture equally and proportionately with all other Notes duly issued hereunder. 
 Section
2.08 Outstanding Notes. 
 The Notes outstanding at any time are all the Notes authenticated by the Trustee except for those canceled
by it, those delivered to it for cancellation, those paid under this Indenture, those reductions in the interest in a Global Note effected by the Trustee in accordance with the provisions hereof, and those described in this Section 2.08 as not
outstanding. Except as set forth in Section 2.09 hereof, a Note does not cease to be outstanding because the Company or an Affiliate of the Company holds the Note; however, Notes held by the Company or a Subsidiary of the Company shall not
be deemed to be outstanding for purposes of Section 3.07(a) hereof.
 If a Note is replaced pursuant to Section 2.07 hereof, it ceases
to be outstanding unless the Trustee receives proof satisfactory to it that the replaced Note is held by a protected purchaser. 
 If the
principal amount of any Note is considered paid under Section 4.01 hereof, it ceases to be outstanding and interest on it ceases to accrue. 

If the Paying Agent (other than the Issuers, a Subsidiary or an Affiliate of any thereof) holds, on a redemption date or maturity date, money
sufficient to pay Notes payable on that date, then on and after that date such Notes will be deemed to be no longer outstanding and will cease to accrue interest. 

  
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 Section 2.09 Treasury Notes. 

In determining whether the Holders of the required principal amount of Notes have concurred in any direction, waiver or consent, Notes owned
by the Issuers or any Guarantor, or by any Person directly or indirectly controlling or controlled by or under direct or indirect common control with the Issuers or any Guarantor, will be considered as though not outstanding, except that for the
purposes of determining whether the Trustee will be protected in conclusively relying on any such direction, waiver or consent, only Notes that a Responsible Officer of the Trustee actually knows are so owned will be so disregarded. 

Section 2.10 Temporary Notes. 
 Until
certificates representing Notes are ready for delivery, the Issuers may prepare and the Trustee, upon receipt of an Authentication Order, will authenticate temporary Notes. Temporary Notes will be substantially in the form of certificated Notes
but may have variations that the Issuers consider appropriate for temporary Notes and as may be reasonably acceptable to the Trustee. Without unreasonable delay, the Issuers will prepare and the Trustee will, upon receipt of an Authentication Order,
authenticate definitive Notes in exchange for temporary Notes. 
 Holders of temporary Notes will be entitled to all of the benefits of this
Indenture. 
 Section 2.11 Cancellation. 

The Issuers at any time may deliver Notes to the Trustee for cancellation. The Registrar and Paying Agent will forward to the Trustee any
Notes surrendered to them for registration of transfer, exchange or payment. The Trustee and no one else will cancel all Notes surrendered for registration of transfer, exchange, payment, replacement or cancellation and will dispose of such
canceled Notes (subject to the record retention requirement of the Exchange Act) and in accordance with the Trustee’s customary procedures. Upon written request and at the expense of the Issuers, certification of the cancellation of such Notes
will be delivered to the Issuers. The Issuers may not issue new Notes to replace Notes that they have paid or that have been delivered to the Trustee for cancellation. 

Section 2.12 Defaulted Interest. 
 If the
Issuers default in a payment of interest on the Notes, they will pay the defaulted interest in any lawful manner plus, to the extent lawful, interest payable on the defaulted interest, to the Persons who are Holders on a subsequent special record
date, in each case at the rate provided in the Notes and in Section 4.01 hereof. The Issuers will notify the Trustee in writing of the amount of defaulted interest proposed to be paid on each Note and the date of the proposed payment. The
Issuers will fix or cause to be fixed each such special record date and payment date; provided, that no such special record date may be less than 10 days prior to the related payment date for such defaulted interest. At least 10 days before
the special record date, the Issuers will deliver or cause to be delivered to Holders a notice that states the special record date, the related payment date and the amount of such interest to be paid. 

Section 2.13 CUSIP or ISIN Numbers 
 The
Issuers in issuing the Notes may use “CUSIP” or “ISIN” numbers (if then generally in use), and, if so, the Trustee shall use “CUSIP” or “ISIN” numbers in notices of redemption as a convenience to Holders;
provided, that any such notice may state that no representation is made as to the correctness of such numbers either as printed on the Notes or as contained in any notice of a redemption and that reliance may be placed only on the other
identification numbers printed on the Notes, and any such redemption shall not be affected by any defect in or omission of such numbers. The Issuers will promptly notify the Trustee in writing of any change in the “CUSIP” or
“ISIN” numbers.

  
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 ARTICLE 3 

REDEMPTION AND PREPAYMENT 
 Section 3.01
Notices to Trustee. 
 If the Issuers elect to redeem Notes pursuant to the optional redemption provisions of Section 3.07
hereof, no later than the delivery of notice to Holders thereof, the Issuers shall notify the Trustee in writing of the redemption date, the principal amount of Notes to be redeemed, the clause of this Indenture pursuant to which the redemption
shall occur and the redemption price (identifying the Notes by CUSIP or ISIN, as applicable). At the Issuers’ written request delivered at least 5 Business Days prior to the applicable date of notice (unless a shorter period shall be
acceptable to the Trustee), the Trustee shall deliver any notice pursuant to Section 3.07 as prepared by the Issuers, to each Holder of Notes to be redeemed in the Issuers’ names and at the Issuers’ expense. Notice given to the
Trustee pursuant to this Section 3.01 may, at the Issuers’ discretion, state that any such redemption may be subject to the satisfaction of one or more conditions precedent.

Section 3.02 Selection of Notes to Be Redeemed or Purchased. 

If less than all of the Notes are to be redeemed, the Trustee will select Notes for redemption or purchase on a pro rata basis (or, in
the case of Notes issued in global form pursuant to Article 2 hereof, based on a method that most nearly approximates a pro rata selection as the Trustee deems fair and appropriate) unless otherwise required by law or applicable stock
exchange or depositary requirements. 
 Upon selection, the Trustee will promptly notify the Issuers in writing of the Notes selected for
redemption or purchase and, in the case of any Note selected for partial redemption or purchase, the principal amount thereof to be redeemed or purchased. Notes and portions of Notes selected will be in amounts of $200,000 or whole multiples of
$1,000 in excess thereof; except that if all of the Notes of a Holder are to be redeemed or purchased, the entire outstanding amount of Notes held by such Holder shall be redeemed or purchased. Except as provided in the preceding sentence,
provisions of this Indenture that apply to Notes called for redemption or purchase also apply to portions of Notes called for redemption or purchase. No Notes of $2,000 or less can be redeemed in part. 

Section 3.03 Notice of Redemption. 

Notices of redemption will be mailed by first class mail (or delivered to DTC in the case of Global Notes) at least 30 days but not more than
60 days before the redemption date to each Holder of Notes to be redeemed at its registered address, except that redemption notices may be mailed (or delivered as the case may be) more than 60 days prior to a redemption date if the notice is issued
in connection with a defeasance of the Notes or a satisfaction and discharge of this Indenture pursuant to Article 8 or 11 hereof. Notice of any redemption of the Notes in connection with a corporate transaction (including an Equity Offering, an
incurrence of Indebtedness or a Change of Control) may, at the Issuers’ discretion, be given prior to the completion thereof and any such redemption or notice may, at the Issuers’ discretion, be subject to one or more conditions precedent,
including, but not limited to, completion of the related transaction. If such redemption or purchase is so subject to satisfaction of one or more conditions precedent, such notice shall describe each such condition, and if applicable, shall state
that, in the Issuers’ discretion, the redemption date may be delayed until such time as any or all such conditions shall be satisfied, or such redemption or purchase may not occur and such notice may be rescinded in the event that any or all
such conditions shall not have been satisfied by the redemption date, or by the redemption 

  
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date as so delayed. In addition, the Issuers may provide in such notice that payment of the redemption price and performance of the Issuers’ obligations with respect to such redemption
may be performed by another Person. 
 If the optional redemption date is on or after an interest record date and on or before the related
interest payment date, the accrued and unpaid interest will be paid to the Person in whose name the Note is registered at the close of business on such record date, and no additional interest will be payable to Holders whose Notes will be subject to
redemption by the Issuers. 
 The notice will identify the Notes (by CUSIP or ISIN, if applicable) to be redeemed and will state: 

(a) the redemption date; 
 (b)
the redemption price; 
 (c) if any Note is to be redeemed in part only, the notice of redemption that relates to that Note will state the
portion of the principal amount of that Note that is to be redeemed and that, after the redemption date upon surrender of such Note, a new Note in principal amount equal to the unredeemed portion of the original Note will be issued in the name of
the Holder of Notes upon cancellation of the original Note; 
 (d) that, on and after the redemption date, interest ceases to accrue on
Notes or portions of Notes called for redemption; 
 (e) the name and address of the Paying Agent; 

(f) that Notes called for redemption must be surrendered to the Paying Agent to collect the redemption price; 

(g) that, unless the Issuers default in making such redemption payment, interest on Notes called for redemption ceases to accrue on and after
the redemption date; 
 (h) if such notice is conditioned upon the occurrence of one or more conditions precedent, the nature of such
conditions precedent; 
 (i) the paragraph of the Notes and/or Section of this Indenture pursuant to which the Notes called for redemption
are being redeemed; and 
 (j) that no representation is made as to the correctness or accuracy of the CUSIP number, if any, listed in such
notice or printed on the Notes. 
 At the Issuers’ written request, the Trustee will give the notice of redemption in the Issuers’
names and at the Issuers’ expense; provided, however, that the Issuers have delivered to the Trustee, at least 30 days prior to the redemption date, an Officer’s Certificate requesting that the Trustee give such notice and
setting forth the information to be stated in such notice as provided in the preceding paragraph. 

  
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 Section 3.04 Effect of Notice of Redemption. 

Once notice of redemption is delivered in accordance with Section 3.03 hereof, Notes called for redemption become irrevocably due and payable
on the redemption date at the redemption price, subject to the satisfaction of any conditions precedent contained in such notice of redemption. 
 Section
3.05 Deposit of Redemption or Purchase Price. 
 If the Issuers elect to redeem Notes in accordance with Section 3.07 hereof, one
Business Day prior to the anticipated redemption or purchase date, the Issuers will deposit with the Trustee or with the Paying Agent money sufficient to pay the redemption or purchase price of accrued interest on all Notes to be redeemed or
purchased on that date. Upon payment of any amount in connection with redemption, the Trustee or the Paying Agent will promptly return to the Issuers any money deposited with the Trustee or the Paying Agent by the Issuers in excess of the
amounts necessary to pay the redemption or purchase price of accrued interest on all Notes to be redeemed or purchased. 
 If the Issuers
comply with the provisions of the preceding paragraph, on and after the redemption or purchase date, interest will cease to accrue on the Notes or the portions of Notes called for redemption or purchase. If a Note is redeemed or purchased on or
after an interest record date but on or prior to the related interest payment date, then any accrued and unpaid interest shall be paid to the Person in whose name such Note was registered at the close of business on such record date. If any
Note called for redemption or purchase is not so paid upon surrender for redemption or purchase because of the failure of the Issuers to comply with the preceding paragraph, interest shall be paid on the unpaid principal, from the redemption or
purchase date until such principal is paid, and to the extent lawful on any interest not paid on such unpaid principal, in each case at the rate provided in the Notes and in Section 4.01 hereof. 

Section 3.06 Notes Redeemed or Purchased in Part. 

Upon surrender of a Note that is redeemed or purchased in part, the Issuers will issue and, upon receipt of an Authentication Order, the
Trustee will authenticate for the Holder at the expense of the Issuers a new Note equal in principal amount to the unredeemed or unpurchased portion of the Note surrendered. 

Section 3.07 Optional Redemption. 
 (a)
At any time prior to November 1, 2019, the Issuers may on any one or more occasions redeem up to 35% of the aggregate principal amount of the Notes issued under this Indenture at a redemption price equal to 108.750% of the aggregate principal
amount of the Notes redeemed, plus accrued and unpaid interest to, but not including, the date of redemption (subject to the rights of Holders of Notes on the relevant record date to receive interest due on the relevant interest payment date if the
Notes have not been redeemed or repurchased prior to such date), with the net cash proceeds of an Equity Offering; provided that: 

(1) at least 65% of the aggregate principal amount of Notes originally issued under this Indenture (excluding Notes held by the
Parent and its Subsidiaries) remains outstanding immediately after the occurrence of such redemption; and 
 (2) the
redemption occurs within 180 days of the date of the closing of such Equity Offering. 

  
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 (b) At any time prior to November 1, 2019, the Issuers may on any one or more occasions
redeem all or a part of the Notes at a redemption price equal to 100% of the principal amount of the Notes redeemed, plus the Applicable Premium as of, and accrued and unpaid interest to, but not including, the date of redemption, subject to the
rights of Holders of Notes on the relevant record date to receive interest due on the relevant interest payment date if the notes have not been redeemed or repurchased prior to such date. 

(c) Except pursuant to this Section 3.07 and Section 3.10 of this Indenture, the Notes will not be redeemable at the Issuers’
option prior to November 1, 2019. 
 (d) On or after November 1, 2019, the Issuers may on any one or more occasions redeem all or
a part of the Notes at the redemption prices (expressed as percentages of principal amount) set forth below, plus accrued and unpaid interest, on the Notes redeemed, to, but not including, the applicable date of redemption, if redeemed during the
twelve-month period beginning on November 1 of the years indicated below (subject to the rights of Holders on the relevant record date to receive interest due on the relevant interest payment date if the Notes have not been redeemed or
repurchased prior to such date): 
  

					
	 Year
	  	Percentage	 
	 2019
	  	 	106.563	% 
	 2020
	  	 	104.375	% 
	 2021
	  	 	102.188	% 
	 2022 and thereafter
	  	 	100.000	% 

 (e) Unless the Issuers default in the payment of the redemption price, interest will cease to accrue on the
Notes or portions thereof called for redemption on the applicable redemption date. 
 (f) Any redemption pursuant to this Section 3.07
shall be made pursuant to the provisions of Sections 3.01 through 3.06 hereof. 
 Section 3.08 Mandatory Redemption. 

The Issuers are not required to make mandatory redemption or sinking fund payments with respect to the Notes. 

Section 3.09 Offer to Purchase. 
 In the
event that, pursuant to Section 4.10 or 4.14 hereof, the Issuers are required to commence an Offer to Purchase, it will follow the procedures specified below. 

Upon the commencement of an Offer to Purchase, the Issuers will deliver a notice to the Trustee and each of the Holders describing the
transaction or transactions that give rise to such Offer to Purchase and offering to repurchase Notes on the date specified in the notice (the “Purchase Date”), which date will be no earlier than 30 days and no later than 60 days
from the date such notice is mailed. The Offer to Purchase will remain open for a period of at least 20 Business Days following its commencement and not more than 30 Business Days, except to the extent that a longer period is required by
applicable law (the “Offer Period”). The purchase price for the Offer to Purchase shall be as set forth in Section 4.10 or 4.14, as applicable; provided that if the Purchase Date is on or after an interest record date and on
or before the related interest payment date, any accrued and unpaid interest will be paid to the Person in whose name a Note is registered at the close of business on such record date.

  
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 The notice will contain all instructions and materials necessary to enable such Holders to tender
Notes pursuant to the Offer to Purchase. The notice, which will govern the terms of the Offer to Purchase, will state:
 (a) that the Offer
to Purchase is being made pursuant to this Section 3.09 and Section 4.10 or 4.14, as applicable, hereof and the length of time the Offer to Purchase will remain open; 

(b) the amount of Excess Proceeds (in the case of an Asset Sale Offer), the purchase price and the Purchase Date; 

(c) that any Note not tendered or accepted for payment will continue to accrete or accrue interest; 

(d) that, unless the Issuers default in making such payment, any Note accepted for payment pursuant to the Offer to Purchase will cease to
accrete or accrue interest after the Purchase Date; 
 (e) that Holders electing to have a Note purchased pursuant to an Offer to Purchase
may elect to have Notes purchased in denominations of $200,000 or an integral multiple of $1,000 in excess thereof; 
 (f) that Holders
electing to have Notes purchased pursuant to any Offer to Purchase will be required to surrender the Note, with the form entitled “Option of Holder to Elect Purchase” attached to the Notes completed, or transfer by book-entry transfer, to
the Issuers, a Depositary, if appointed by the Issuers, or a Paying Agent at the address specified in the notice at least three days before the Purchase Date; 

(g) that Holders will be entitled to withdraw their election if the Issuers, the Depositary or the Paying Agent, as the case may be, receives,
not later than the expiration of the Offer Period, facsimile transmission or letter setting forth the name of the Holder, the principal amount of the Note the Holder delivered for purchase and a statement that such Holder is withdrawing his election
to have such Note purchased; 
 (h) in the case of an Asset Sale Offer, that, if the aggregate principal amount of Notes and other pari
passu Indebtedness surrendered by holders thereof exceeds the Offer Amount, the Trustee, after consultation with the Issuers, will select the Notes and other pari passu Indebtedness to be purchased on a pro rata basis based on the
principal amount of Notes and such other pari passu Indebtedness surrendered (with such adjustments as may be deemed appropriate by the Issuers so that only Notes in denominations of $200,000, or an integral multiple of $1,000 in excess
thereof, will be purchased); and 
 (i) that Holders whose Notes were purchased only in part will be issued new Notes equal in principal
amount to the unpurchased portion of the Notes surrendered (or transferred by book-entry transfer). 
 On the Purchase Date, the Issuers
will, to the extent lawful: 
 (1) accept for payment all notes or portions of Notes properly tendered pursuant to the Offer
to Purchase (which may be limited to the pro rated amount of Excess Proceeds in the case of an Asset Sale Offer as set forth in Section 4.10); 

(2) deposit with the Paying Agent an amount equal to the purchase price in respect of all notes or portions of Notes properly
tendered; and 
 (3) deliver or cause to be delivered to the Trustee the Notes properly accepted together with an
Officer’s Certificate stating the aggregate principal amount of Notes or portions of Notes being purchased by the Issuers pursuant to this Section 3.09 and a written order to cancel those Notes (in accordance with the Trustee’s
procedures). 

  
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 The Issuers, the Depositary or the Paying Agent, as the case may be, will promptly mail or
deliver to each tendering Holder an amount equal to the purchase price of the Notes tendered by such Holder and accepted by the Issuers for purchase, and the Issuers will promptly issue a new Note, and the Trustee, upon written request from the
Issuers, will authenticate and mail or deliver (or cause to be transferred by book entry) such new Note to such Holder, in a principal amount equal to any unpurchased portion of the Note surrendered. Any Note not so accepted shall be promptly mailed
or delivered by the Issuers to the Holder thereof. The Issuers will publicly announce the results of the Offer to Purchase as soon as practicable on or after the Purchase Date. 

The Issuers will comply with the requirements of Rule 14e-1 under the Exchange Act and any other securities laws and regulations thereunder to
the extent those laws and regulations are applicable in connection with each repurchase of notes pursuant to an Offer to Purchase. To the extent that the provisions of any securities laws or regulations conflict with the provisions of the
indenture governing such Offer to Purchase, the Issuers will comply with the applicable securities laws and regulations and will not be deemed to have breached its obligations under such provisions of this Indenture by virtue of such compliance.

 The provisions under the indenture relative to the Issuers’ obligation to make any Offer to Purchase may be waived or modified with
the consent of the Holders of a majority in principal amount of the Notes. 
 Section 3.10 Redemption for Changes in Taxes 

The Issuers may redeem the Notes, in whole but not in part, at their discretion at any time upon giving not less than 30 nor more than 60
days’ notice to the Holders thereof (which notice shall be irrevocable and given in accordance with the procedures described under Section 3.02), at a redemption price equal to 100% of the principal amount of the Notes redeemed, plus
accrued and unpaid interest to, but not including, the date of redemption (a “Tax Redemption Date”) and all Additional Amounts (if any) then due and that will become due on the Tax Redemption Date as a result of the redemption or
otherwise (subject to the right of Holders of the Notes on the relevant record date to receive interest due on the relevant interest payment date and Additional Amounts (if any) in respect thereof if the Notes have not been redeemed or repurchased
prior to such date), if on the next date on which any amount would be payable in respect of the Notes, the Issuers or any Guarantor is or would be required to pay Additional Amounts, and the Issuers or such Guarantor (but, in the case of a
Guarantor, only if the payment giving rise to such requirement cannot be made by the Issuers or another Guarantor without the obligation to pay Additional Amounts) cannot avoid any such payment obligation by taking commercially reasonable measures
available to them (including, for the avoidance of doubt, the appointment of a new Paying Agent), and the requirement to pay such Additional Amounts arises as a result of: 

(a) any change in, or amendment to, the laws (or any regulations or rulings promulgated thereunder) of the relevant Tax
Jurisdiction affecting taxation, which change or amendment has not been publicly announced before and becomes effective after the Issue Date (or, if the relevant Tax Jurisdiction became a Tax Jurisdiction on the Issue Date, such later date); or 

(b) any change in, or amendment to, the existing official published position regarding the application, administration or
interpretation of such laws, regulations or rulings (including by virtue of a holding, judgment or order by a court of competent jurisdiction or a change in published administrative practice), which change or amendment has not been publicly
announced before and becomes effective after the Issue Date (or, if the relevant Tax Jurisdiction became a Tax Jurisdiction on a date after the Issue Date, such later date).

  
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 The Issuers will not give any such notice of redemption earlier than 60 days prior to the
earliest date on which the Issuers or the applicable Guarantors would be obligated to make such payment or withholding if a payment in respect of the Notes were then due and at the time such notice is given, the obligation to pay Additional Amounts
must remain in effect. Prior to the publication or, where relevant, delivery of any notice of redemption of the Notes pursuant to the foregoing, the Issuers will deliver to the trustee an opinion of independent tax counsel of recognized
standing (which counsel shall be reasonably acceptable to the trustee) attesting to the effect that there has been such a change or amendment which would entitle the Issuers to redeem the Notes under this Indenture (which opinion, for the avoidance
of doubt, shall not be required to include an opinion as to whether “commercially reasonable efforts” could be undertaken to avoid the otherwise applicable obligations). In addition, before the Issuers publish or mail notice of
redemption of the Notes pursuant to the forgoing, they will deliver to the trustee an Officer’s Certificate to the effect that they cannot avoid the obligation to pay Additional Amounts by taking commercially reasonable measures available to
them. 
 The Trustee will accept and shall be entitled to conclusively rely on such Officer’s Certificate and Opinion of Counsel as
sufficient evidence of the existence and satisfaction of the conditions as described above, in which event it will be conclusive and binding on all of the Holders. 

ARTICLE 4 
 COVENANTS 

Section 4.01 Payment of Notes. 
 The
Issuers will pay or cause to be paid the principal of, premium on, if any, and interest on, the Notes on the dates and in the manner provided in the Notes. Principal, premium, if any, and interest will be considered paid on the date due if the
Paying Agent, if other than the Issuers or a Subsidiary thereof, holds as of 10:00 a.m. (New York City Time) on the due date money deposited by the Issuers in immediately available funds and designated for and sufficient to pay all principal,
premium, if any, and interest, if any, then due.
 The Issuers will pay interest (including post-petition interest in any proceeding under
any Bankruptcy Law) on overdue principal at the then applicable interest rate on the Notes to the extent lawful; it will pay interest (including post-petition interest in any proceeding under any Bankruptcy Law) on overdue installments of interest,
if any (without regard to any applicable grace period), at the same rate to the extent lawful. 
 Section 4.02 Maintenance of Office or Agency.
 
 The Issuers will maintain in each Place of Payment for Notes an office or agency where Notes may be presented or surrendered for
payment, where Notes may be surrendered for registration of transfer or for exchange and where notices and demands to or upon the Issuers in respect of the Notes and this Indenture may be served. The Issuers will give prompt written notice to
the Trustee of the location, and any change in the location, of such office or agency. If at any time the Issuers fail to maintain any such required office or agency or fails to furnish the Trustee with the address thereof, such presentations,


  
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surrenders, notices and demands may be made or served at the Corporate Trust Office of the Trustee, and the Issuers hereby appoint the Trustee as their agent to receive all such presentations,
surrenders, notices and demands. 
 The Issuers may also from time to time designate one or more other offices or agencies where the Notes
may be presented or surrendered for any or all such purposes and may from time to time rescind such designations; provided, however, that no such designation or rescission will in any manner relieve the Issuers of their obligation to maintain
an office or agency in each Place of Payment for Notes for such purposes. The Issuers will give prompt written notice to the Trustee of any such designation or rescission and of any change in the location of any such other office or agency.

 The Issuers hereby designate the Corporate Trust Office of the Trustee as one such office or agency of the Issuers in accordance with
Section 2.03 hereof. 
 Section 4.03 Reports.  

(a) Whether or not required by the SEC’s rules and regulations, so long as any Notes are outstanding, the Parent shall furnish to the
Trustee, within 15 days of the time periods specified in the SEC’s rules and regulations (giving effect to any grace period provided by Rule 12b-25 or any successor rule under the Exchange Act), all quarterly and annual reports that would
be required to be filed with the SEC on Forms 10-Q and 10-K (or any successor form) if the Parent were required to file such reports (excluding any such information, documents or reports, or portions thereof, subject to confidential
treatment). This Indenture will permit the Parent to satisfy its obligations in this covenant by furnishing annual and quarterly reports prepared by a parent entity, so long as (i), to the extent there are, in the Parent’s reasonable
judgment, material differences between the information relating to that parent entity, on the one hand, and the information relating to the Parent and the Restricted Subsidiaries, on the other hand, such differences and financial discrepancies are
reasonably detailed in such report or (ii) the Parent causes such parent entity to become a Guarantor in accordance with this Indenture (and in such instance any reference to Guarantor shall be deemed to include such entity). The Parent
will not be required to provide the trustee with any such information, documents or reports that are filed with the SEC and the trustee shall have no responsibility whatsoever to determine if such reports and information have been filed with the
SEC. 
 (b) Notwithstanding anything herein to the contrary, in the event that the Parent fails to comply with its obligation to file or
provide such information, documents and reports as required hereunder, the Parent will be deemed to have cured such Default for purposes of Section 6.01(3) hereof upon the provision of all such information, documents and reports required
hereunder prior to the expiration of 60 days after written notice to the Parent of such failure from the Trustee or the Holders of at least 25% of the principal amount of the Notes. 

(c) For so long as any Restricted Notes are outstanding the Parent agrees that, in order to render such Restricted Notes eligible for resale
pursuant to Rule 144A under the Securities Act, it will make available, upon request, to any Holder of Restricted Notes or prospective purchasers of Restricted Notes the information specified in Rule 144A(d)(4), unless the Parent furnishes such
information to the SEC pursuant to Section 13 or 15(d) of the Exchange Act. 
 (d) Delivery of such reports, information and documents
to the Trustee is for informational purposes only and the Trustee’s receipt of such shall not constitute constructive or actual notice of any information contained therein or determinable from information contained therein, including the
Parent’s compliance with any of its covenants hereunder (as to which the Trustee is entitled to rely conclusively on Officer’s Certificates). The Trustee is under no duty to examine such reports, information or documents to ensure
compliance with the provision of this indenture or to ascertain the correctness or otherwise of the information or the statements contained therein. 

  
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 Section 4.04 Compliance Certificate.  

(a) The Parent shall deliver to the Trustee, within one hundred twenty (120) days after the end of each fiscal year of the Parent
(commencing with the fiscal year ending December 31, 2016), an Officer’s Certificate, indicating whether the signer thereof knows of any Default or Event of Default that occurred during the previous fiscal year and specifying all such
Defaults or Events of Default, the nature and the status thereof and the actions which the Issuers propose to take with respect thereto.

(b) The Parent shall deliver to the Trustee, within 30 days after the Parent becomes aware of the occurrence of any Default or Event of
Default, a written notice of such Default or Event of Default, its status and the action which the Parent is taking or proposing to take with respect thereof; provided that the Issuers shall not be required to deliver such notice if such
Default or Event of Default has been cured.
 Section 4.05 Reserved.  

Section 4.06 Stay, Extension and Usury Laws.  

The Issuers and each of the Guarantors covenants (to the extent that it may lawfully do so) that it will not at any time insist upon, plead,
or in any manner whatsoever claim or take the benefit or advantage of, any stay, extension or usury law wherever enacted, now or at any time hereafter in force, that may affect the covenants or the performance of this Indenture; and the Issuers and
each of the Guarantors (to the extent that it may lawfully do so) hereby expressly waives all benefit or advantage of any such law, and covenants that it will not, by resort to any such law, hinder, delay or impede the execution of any power herein
granted to the Trustee, but will suffer and permit the execution of every such power as though no such law has been enacted.
 Section 4.07 Restricted
Payments.  
 (a) The Parent will not, and will not permit any of the Restricted Subsidiaries to, directly or indirectly: 

(1) declare or pay any dividend or make any other payment or distribution on account of the Parent’s or any of the
Restricted Subsidiaries’ Equity Interests (including, without limitation, any payment in connection with any merger or consolidation involving the Parent or any of the Restricted Subsidiaries, other than any such merger or consolidation
constituting a Permitted Investment) or to the direct or indirect Holders of the Parent’s or any of the Restricted Subsidiaries’ Equity Interests in their capacity as such (other than (i) dividends or distributions payable in Equity
Interests (other than Disqualified Stock) of the Parent, (ii) dividends or distributions payable to the Parent or a Restricted Subsidiary, (iii) dividends or distributions payable to other Holders of Equity Interests of a Subsidiary of the Parent on
no more than a pro rata basis and (iv) payments on account of the transfer or issuance of Equity Interests to Parent or any Restricted Subsidiary; provided that such payments constitute Permitted Investments); 

(2) purchase, redeem or otherwise acquire or retire for value, directly or indirectly (including, without limitation, in
connection with any merger or consolidation involving the Parent), any Equity Interests of the Parent; 

  
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 (3) make any principal payment on or with respect to, or purchase, redeem,
defease or otherwise acquire or retire for value any Indebtedness of the Parent or any Guarantor that is contractually subordinated to the Notes or to any Note Guarantee (excluding any intercompany Indebtedness between or among the Parent and any of
the Restricted Subsidiaries), except a payment of principal at, or within 365 days of, the Stated Maturity thereof; or 
 (4)
make any Restricted Investment 
 (all such payments and other actions set forth in these clauses (1) through (4) above being collectively
referred to as “Restricted Payments”), unless: 
  

	 	(i)	at the time of such Restricted Payment no Default or Event of Default has occurred and is continuing or would occur as a consequence of such Restricted Payment; 


 

	 	(ii)	immediately after giving effect to such Restricted Payment, on a pro forma basis as if such Restricted Payment had been made at the beginning of the applicable four-quarter period, the Parent would be permitted to incur
at least $1.00 of additional Indebtedness pursuant to the Fixed Charge Coverage Ratio test set forth in Section 4.09(a); and 

  

	 	(iii)	such Restricted Payment, together with the aggregate amount of all other Restricted Payments made by the Parent and the Restricted Subsidiaries since April 29, 2015 (including Restricted Payments permitted by Section
4.07(b)(1), but excluding all other Restricted Payments permitted by Section 4.07(b)), is less than the sum, without duplication, of: 


(A) 50% of the Consolidated Net Income of the Parent for the period (taken as one accounting period) from April 1, 2015 to the
end of the Parent’s most recently ended fiscal quarter for which internal financial statements are available at the time of such Restricted Payment (or, if such Consolidated Net Income for such period is a deficit, less 100% of such deficit);
plus  
 (B) 100% of the aggregate Net Cash Proceeds received by the Parent since April 29, 2015 as a contribution to
its common equity capital or from the issue or sale of Qualifying Equity Interests of the Parent or from the issue or sale of convertible or exchangeable Disqualified Stock of the Parent or convertible or exchangeable debt securities of the Parent,
in each case that have been converted into or exchanged for Qualifying Equity Interests of the Parent (other than Qualifying Equity Interests and convertible or exchangeable Disqualified Stock or debt securities sold to a Subsidiary of the Parent);
plus 
 (C) 100% of the aggregate amount received in cash and the Fair Market Value of property (other than cash) and
marketable securities received by the Parent or a Restricted Subsidiary after April 29, 2015 by means of (i) the sale or other disposition (other than to the Parent or a Restricted Subsidiary) of Restricted Investments made by the Parent or any
Restricted Subsidiary and repurchases and redemptions of such Restricted Investments from the Parent or any Restricted Subsidiary and repayments of loans or advances which constitute Restricted Investments of the Parent or any Restricted Subsidiary,
(ii) the sale (other than to the Parent or a Restricted Subsidiary) of the Equity Interests of an Unrestricted Subsidiary, (iii) payments of interests, distributions or 

  
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dividends received in respect of Restricted Investments and (iv) a distribution or dividend from an Unrestricted Subsidiary (other than in each case to the extent such Investment constituted
a Permitted Investment), in each case to the extent that such amounts were not otherwise included in the Consolidated Net Income of the Parent for such period; plus  

(D) to the extent that any Restricted Investment that was made after April 29, 2015 is made in an entity that subsequently
becomes a Restricted Subsidiary, the initial amount of such Restricted Investment (or, if less, the amount of cash received upon repayment or sale); plus 

(E) to the extent that any Unrestricted Subsidiary designated as such after April 29, 2015 is redesignated as a Restricted
Subsidiary after April 29, 2015, the lesser of (i) the Fair Market Value of the Restricted Investment in such Subsidiary as of the date of such redesignation or (ii) the aggregate amount of the Restricted Investments in such Subsidiary to
the extent such Restricted Investments reduced the amount available under this clause (c) and were not previously repaid or otherwise reduced. 

(b) Section 4.07(a) will not prohibit: 

(1) the payment of any dividend or distribution or the consummation of any redemption within 60 days after the date of
declaration thereof or giving of the redemption notice, as the case may be, if at the date of declaration or notice, the dividend, distribution or redemption payment would have complied with the provisions of this Indenture;

(2) the making of any Restricted Payment in exchange for, or out of or with the Net Cash Proceeds of the substantially
concurrent sale (other than to a Subsidiary of the Parent) of, Equity Interests of the Parent (other than Disqualified Stock) or from the substantially concurrent contribution of common equity capital to the Parent; provided that the amount
of any such Net Cash Proceeds that are utilized for any such Restricted Payment will not be considered to be Net Cash Proceeds of Qualifying Equity Interests for purposes of Section 4.07(a)(iii)(B) and will not be considered to be net cash proceeds
from an Equity Offering for purposes of Section 3.07; 
 (3) the repurchase, redemption, defeasance or other acquisition or
retirement for value of Indebtedness that is contractually subordinated to the Notes or to any Note Guarantee with the Net Cash Proceeds from a substantially concurrent incurrence of Permitted Refinancing Indebtedness; 

(4) the repurchase, redemption or other acquisition or retirement for value of any Equity Interests of the Parent, any
Restricted Subsidiary or the Parent’s direct or indirect parent companies held by any current or former officer, director, manager, employee or consultant of the Parent or any of its Subsidiaries pursuant to any equity subscription agreement,
stock option agreement, shareholders’ agreement or other similar agreement; provided that the aggregate price paid for all such repurchased, redeemed, acquired or retired Equity Interests may not exceed $15.0 million in any calendar year
(with any unused amount in any calendar year being carried forward and available in the next succeeding year); provided, further, that such amount in any twelve-month period may be increased by an amount not to exceed: 

(a) the Net Cash Proceeds from the sale of Qualifying Equity Interests of the Parent and, to the extent contributed to the
Parent as common equity capital, the Net Cash Proceeds from the sale of Qualifying Equity Interests of any of the Parent’s direct or indirect 

  
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parent companies, in each case to any current of former officer, director, manager, employee or consultant of the Parent, any of its Subsidiaries or any of its direct or indirect parent companies
that occurs after April 29, 2015 to the extent the Net Cash Proceeds from the sale of Qualifying Equity Interests have not otherwise been applied to the making of Restricted Payments pursuant to Section 4.07(a)(iii) or Section 4.07(b)(2) or to an
optional redemption of Notes pursuant to Section 3.07; plus 
 (b) the cash proceeds of key man life insurance
policies received by the Parent or the Restricted Subsidiaries after the Issue Date; and 
 in addition, cancellation of Indebtedness owing
to the Parent from any current or former officer, director, manager, employee or consultant (or any permitted transferees thereof) of the Parent or any of its Subsidiaries (or any direct or indirect parent company thereof), in connection with a
repurchase of Equity Interests of the Parent or the Parent’s direct or indirect parent companies from such Persons will not be deemed to constitute a Restricted Payment for purposes of this Section 4.07 or any other provisions of this
Indenture; 
 (5) the repurchase of Equity Interests of the Parent or the Parent’s direct or indirect parent companies
(a) deemed to occur upon the exercise of stock options, warrants or convertible securities to the extent such Equity Interests represent a portion of the exercise price of those stock options, warrants or convertible securities, (b) upon
the exercise of stock options, warrants or convertible securities in an equal or lesser amount to the amount exercised in order to reduce the dilutive effects of such exercise, and (c) deemed to occur upon the withholding of a portion of Equity
Interests granted or awarded to any current or former officer, director, manager, employee or consultant to pay for taxes payable by such Person in connection with such grant or award (or the vesting thereof) (or a Restricted Payment to any of the
Parent’s direct or indirect parent companies in an amount sufficient to enable such company to repurchase any such Equity Interests); 

(6) the declaration and payment of dividends to Holders of any class or series of Disqualified Stock of the Parent or any
Preferred Stock of any Restricted Subsidiary permitted to be issued under Section 4.09, so long as such dividends are included in the definition of “Fixed Charges;” 

(7) payments to Holders of Equity Interests (or to the Holders of Indebtedness that is convertible into or exchangeable for
Equity Interests upon such conversion or exchange) in lieu of the issuance of fractional shares (or a Restricted Payment to the Parent’s direct or indirect parent company in an amount sufficient to enable such company to make any such
payments); 
 (8) payments of intercompany subordinated Indebtedness, the Incurrence of which was permitted under Section
4.09(b); 
 (9) the repurchase, redemption or other acquisition or retirement for value of any Indebtedness of the Parent,
the Issuers or any other Guarantor that is contractually subordinated to the Notes or to any Note Guarantee pursuant to provisions similar to Sections 4.10 and 4.14; provided that, prior to consummating, or concurrently with, any such
repurchase, the Issuers have made any Offer to Purchase required by this Indenture and has repurchased all notes validly tendered for payment in connection with such offers; 

(10) the distribution, as a dividend or otherwise, of Equity Interests of, or Indebtedness owed to the Parent or a Restricted
Subsidiary by, Unrestricted Subsidiaries (other than Investments in Capital Stock of or Indebtedness in Permitted Joint Ventures pursuant to clause (18)(b) of the definition of “Permitted Investments”); 

  
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 (11) the declaration and payment of dividends or distributions to Holders of any
class or series of Preferred Stock (other than Disqualified Stock) of the Parent or any of the Restricted Subsidiaries issued after April 29, 2015; provided that, immediately after giving pro forma effect to the issuance of such Preferred
Stock (assuming the payment of dividends thereon even if permitted to accrue under the terms thereof), the Parent could Incur at least $1.00 of additional Indebtedness pursuant to Section 4.09(a); 

(12) the repurchase, redemption, defeasance or other retirement for value of any Permitted Convertible Indebtedness, including
any payments required in connection with a conversion of any Permitted Convertible Indebtedness; 
 (13) payments or
distributions made in Equity Interests (other than Disqualified Stock) of the Parent or any of its direct or indirect parent companies; 

(14) payments made in connection with (including, without limitation, purchases of) any Permitted Bond Hedge Transaction; 

(15) payments made (a) to exercise or settle any Permitted Warrant Transaction (i) by delivery of common or ordinary
Capital Stock of the Parent or any of its direct or indirect parent companies, (ii) by set-off against the related Permitted Bond Hedge Transaction or (iii) with cash payments in an aggregate amount not to exceed the aggregate amount of
any payments received by the Parent or any of the Restricted Subsidiaries pursuant to the exercise or settlement of any related Permitted Bond Hedge Transaction, or (b) to terminate any Permitted Warrant Transaction; 

(16) [reserved]; 

(17) payments or distributions to dissenting stockholders pursuant to applicable law in connection with any merger or
consolidation with, or other acquisition of, another Person; 
 (18) the purchase by the Parent or any Restricted Subsidiary
of any remaining outstanding Equity Interests of any Subsidiary acquired in connection with a Permitted Investment structured as a tender offer pursuant to which not less than a majority of such Subsidiary’s Equity Interests has been acquired
by the Parent or any Restricted Subsidiary; 
 (19) the settlement or termination of any Permitted Equity Derivatives;
provided that the entry into such Permitted Equity Derivative was permitted under this covenant; and 
 (20) so long
as no Default or Event of Default has occurred and is continuing, other Restricted Payments in an aggregate amount not to exceed the greater of $90.0 million or 3.0% of Total Assets since the Issue Date. 

(c) The amount of all Restricted Payments (or transfer or issuance that would constitute Restricted Payments but for the exclusions from the
definition thereof) and Permitted Investments (other than cash) will be the Fair Market Value, on the date of making the Restricted Payment (or such transfer or issuance) or Permitted Investment of the asset(s) or securities proposed to be
transferred or issued by the Parent or such Restricted Subsidiary, as the case may be, pursuant to the Restricted Payment (or transfer or issuance that would constitute a Restricted Payment but for the exclusions from the definition thereof) or
Permitted Investment, less, in the case of an Investment, any amount paid, repaid, returned, distributed or otherwise received in cash in respect of such Investment. 

  
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 Section 4.08 Dividend and Other Payment Restrictions Affecting Restricted Subsidiaries.  

(a) The Parent will not, and will not permit any of the Restricted Subsidiaries, to create or permit to exist or become effective any
consensual encumbrance or restriction on the ability of any Restricted Subsidiary to: 
 (1) pay dividends or make any other
distributions on its Capital Stock to the Parent or any of the Restricted Subsidiaries or pay any indebtedness owed to the Parent or any of the Restricted Subsidiaries; 

(2) make loans or advances to the Parent or any of the Restricted Subsidiaries; or 

(3) sell, lease or transfer any of its properties or assets to the Parent or any of the Restricted Subsidiaries. 

(b) The restrictions in Section 4.08(a) will not apply to encumbrances or restrictions existing under or by reason of: 

(1) agreements in effect at or entered into on the Issue Date; 

(2) this Indenture, the Notes, the Note Guarantees and the Credit Agreement; 

(3) agreements governing other Indebtedness permitted to be incurred under Section 4.09, provided that, except with
respect to any such Incurrence of Indebtedness under the Credit Agreement, in the judgment of the Parent, such incurrence will not materially impair the Parent’s and Issuers’ ability to make payments under the Notes and the Note Guarantees
when due (as determined in good faith by senior management or the Board of Directors of the Parent); 
 (4) applicable law,
rule, regulation, order, approval, license, permit or similar restriction; 
 (5) any agreement or instrument governing
Indebtedness, the assets or the Equity Interests of a Person acquired by the Parent or any of the Restricted Subsidiaries as in effect at the time of such acquisition (except to the extent such agreement or instrument was entered into, or such
Indebtedness was incurred, in connection with or in contemplation of such acquisition), which encumbrance or restriction is not applicable to any Person, or the properties or assets of, or Equity Interests of, any Person, other than the Person, or
the property or assets of, or Equity Interests of the Person, so acquired; provided that, in the case of Indebtedness, such Indebtedness was permitted by the terms of this Indenture to be Incurred; 

(6) customary non-assignment provisions in contracts, leases, licenses and other commercial or trade agreements entered into in
the ordinary course of business; 
 (7) Capital Lease Obligations, any agreement governing Purchase Money Indebtedness,
security agreements or mortgages securing Indebtedness of a Restricted Subsidiary to the extent such encumbrance or restriction restricts the transfer of the property subject to such Capital Lease Obligations, Purchase Money Indebtedness, security
agreements or mortgages; 

  
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 (8) any agreement in connection with the sale or disposition of Equity Interests
or assets of a Restricted Subsidiary that imposes such encumbrance or restriction pending the closing of such sale or disposition (including, without limitation, the Andromeda Release Agreement); 

(9) Permitted Refinancing Indebtedness; provided that the restrictions contained in the agreements governing such
Permitted Refinancing Indebtedness are not materially more restrictive, taken as a whole (as reasonably determined by the Parent), than those contained in the agreements governing the Indebtedness being refinanced; 

(10) Liens permitted to be incurred under Section 4.12 that limit the right of a Restricted Subsidiary to dispose of the assets
subject to such Liens; 
 (11) provisions limiting the disposition or distribution of assets or property in joint venture
agreements, asset sale agreements, sale-leaseback agreements, stock sale agreements and other similar agreements (including agreements entered into in connection with a Restricted Investment), which limitation is applicable only to the assets that
are the subject of such agreements; 
 (12) prohibitions, restrictions or conditions on cash or other deposits or net worth
imposed by customers under contracts entered into in the ordinary course of business; 
 (13) customary provisions contained
in leases, sub-leases, licenses, sub-licenses or similar agreements, including with respect to intellectual property, and other agreements, in each case, entered into in the ordinary course of business; 

(14) customary non-assignment provisions in leases or licenses governing leasehold or license interests to the extent such
provisions restrict the transfer of the lease or license or the property leased or licensed thereunder; 
 (15) contractual
requirements of a Securitization Special Purpose Entity in connection with a Qualified Securitization Transaction; provided that such restrictions apply only to such Securitization Special Purpose Entity; and 

(16) any amendment, modification, restatement, renewal, increase, supplement, refunding, replacement or refinancing of an
agreement or arrangement referred to in clauses (1) through (15) above of this Section 4.08(b); provided, however, that such amendment, modification, restatement, renewal, increase, supplement, refunding, replacement or refinancing is
not materially more restrictive, as reasonably determined by the Parent, with respect to such encumbrances and other restrictions taken as a whole than those prior to such amendment, modification, restatement, renewal, increase, supplement,
refunding, replacement or refinancing. 
 Section 4.09 Incurrence of Indebtedness and Issuance of Preferred Stock. 

(a) The Parent will not, and will not permit any Restricted Subsidiary to, Incur, directly or indirectly, any Indebtedness, and the Parent
will not issue any Disqualified Stock and will not permit any of the Restricted Subsidiaries to issue any shares of Preferred Stock; provided, however, that the Parent will be entitled to Incur Indebtedness (including Acquired Indebtedness)
or issue Disqualified Stock and any Restricted Subsidiary will be entitled to Incur Indebtedness or issue Preferred Stock if, on the date of such Incurrence or issuance and after giving effect thereto on a pro forma basis, the Fixed Charge Coverage
Ratio would be at least 2.0 to 1.0; provided that Non-Guarantor Subsidiaries may not incur 

  
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Indebtedness or issue Preferred Stock under this paragraph if, after giving pro forma effect to such Incurrence (including a pro forma application of the net proceeds therefrom), more than $60.0
million of Indebtedness or Preferred Stock of Non-Guarantor Subsidiaries incurred pursuant to this paragraph would then be outstanding. 

(b) Notwithstanding Section 4.09(a), the Parent and the Restricted Subsidiaries will be entitled to Incur any or all of the following
Indebtedness (collectively, “Permitted Debt”): 
 (1) Indebtedness Incurred pursuant to the Credit Agreement;
provided, however, that, immediately after giving effect to any such Incurrence, the aggregate principal amount of all Indebtedness Incurred under this clause (1) and then outstanding does not exceed $1,000.0 million; provided,
that the Parent or the Restricted Subsidiaries can Incur additional Indebtedness under this clause (1) if, after giving pro forma effect to such Incurrence, the Consolidated Senior Secured Debt Ratio would be no greater than 3.5 to 1.0;
provided that for purposes of determining the amount of Indebtedness that may be incurred under clause (1), all Indebtedness incurred under this clause (1) shall be treated as Secured Indebtedness; 

(2) Indebtedness owed to and held by the Parent or a Restricted Subsidiary; provided, however, that (a) any subsequent
issuance or transfer of any Capital Stock that results in any such Indebtedness being held by a Person other than the Parent or a Restricted Subsidiary and (b) any subsequent transfer of such Indebtedness (other than to the Parent or a Restricted
Subsidiary) shall be deemed, in each case, to constitute the Incurrence of such Indebtedness by the obligor thereon that was not permitted by this clause (2). 

(3) the Notes (including any Note Guarantees but excluding any additional notes); 

(4) Indebtedness that is outstanding on the Issue Date (other than Indebtedness described in clause (1), (2) or
(3) of this Section 4.09(b)); 
 (5) Acquired Indebtedness (other than Indebtedness Incurred in connection with, or to
provide all or any portion of the funds or credit support utilized to consummate, the transaction or series of related transactions pursuant to which such Subsidiary became a Subsidiary or was acquired by the Parent or such Restricted Subsidiary);
provided, however, that on the date of such acquisition and after giving effect thereto on a pro forma basis, either (a) the Parent would be entitled to Incur at least $1.00 of additional Indebtedness pursuant to the first
paragraph of this covenant or (b) the Fixed Charge Coverage Ratio would not be less than such Fixed Charge Coverage Ratio immediately prior to such acquisition; 

(6) Permitted Refinancing Indebtedness in respect of Indebtedness Incurred pursuant to Section 4.09(a) or Sections 4.09(b)(3),
(4), (5), (19) of this Section 4.09 or this clause (6); 
 (7) Hedging Obligations directly related to Indebtedness permitted
to be Incurred by the Parent and the Restricted Subsidiaries pursuant to this Indenture or entered into in the ordinary course of business and not for speculative purposes; 

(8) (a) obligations in respect of worker’s compensation and self-insurance and performance, indemnity, bid, stay, customs,
appeal, replevin and surety bonds, performance and completion guarantees and other similar bonds or guarantees, in each case provided by the Parent or any Restricted Subsidiary in the ordinary course of business and (b) reimbursement and
indemnification obligations in respect of letters of credit, banker’s acceptances and other similar instruments issued in respect of obligations specified in clause (a) or to landlords or vendors in the ordinary course of business; 

  
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 (9) Indebtedness arising from (a) the honoring by a bank or other financial
institution of a check, draft, or similar instrument drawn against insufficient funds in the ordinary course of business or other cash management services in the ordinary course of business; provided, that such Indebtedness is extinguished
within ten Business Days of notification to the Parent of its incurrence; (b) customer deposits and advance payments received in the ordinary course of business or consistent with past practice from customers for goods or services purchased in
the ordinary course of business or consistent with past practice; and (c) Treasury Management Arrangements; 
 (10)
Indebtedness consisting of any Guarantee by (a) the Parent or another Guarantor of Indebtedness or other Obligations of the Parent, the Issuers or any of the other Guarantors, (b) a Foreign Subsidiary of Indebtedness or other Obligations
of another Foreign Subsidiary or a Non-Guarantor Subsidiary or (c) a Non-Guarantor Subsidiary of Indebtedness or other Obligations of another Non-Guarantor Subsidiary or a Foreign Subsidiary, in each case so long as the Incurrence of such
guaranteed Indebtedness or other obligations by the Parent or such Restricted Subsidiary is permitted under the terms of this Indenture; provided, that, if the Indebtedness being guaranteed is subordinated to or pari passu with the
Notes, then the Guarantee must be subordinated or pari passu, as applicable, to the same extent as the Indebtedness guaranteed; 

(11) Capital Lease Obligations and Purchase Money Indebtedness, and Permitted Refinancing Indebtedness in respect thereof, in
an aggregate principal amount on the date of Incurrence that, when taken together with the principal amount of all other Indebtedness then outstanding and Incurred pursuant to this clause (11), does not exceed the greater of $22.5 million or 1.0% of
Total Assets; 
 (12) Indebtedness of Non-Guarantor Subsidiaries and Foreign Subsidiaries in an aggregate principal amount on
the date of Incurrence that, when taken together with the principal amount of all other Indebtedness then outstanding and Incurred pursuant to this clause (12), does not exceed the greater of $22.5 million or 1.0% of Total Assets; 

(13) Indebtedness of the Parent or any of the Restricted Subsidiaries consisting of (a) the financing of insurance
premiums with the providers of such insurance or their affiliates or (b) take-or-pay obligations contained in supply agreements, in each case, in the ordinary course of business; 

(14) Indebtedness of the Parent or any of the Restricted Subsidiaries supported by a letter of credit issued pursuant to the
Credit Agreement in a principal amount not in excess of the stated amount of such letter of credit; 
 (15) Indebtedness
consisting of guarantees of indebtedness or other obligations of joint ventures permitted under clause (18) of the definition of “Permitted Investments;” 

(16) Indebtedness Incurred in connection with judgments, decrees, attachments or awards that do not constitute an Event of
Default under Section 6.01(5); 
 (17) Indebtedness in the form of (a) guarantees of loans and advances to officers,
directors, consultants and employees, in an aggregate amount not to exceed $7.5 million at any 

  
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one time outstanding, and (b) reimbursements owed to officers, directors, consultants and employees of the Parent, any of its Subsidiaries or the Parent’s direct or indirect parent
companies; 
 (18) Indebtedness consisting of obligations to make payments to current or former officers, directors and
employees of the Parent, any of its Subsidiaries or the Parent’s direct or indirect parent companies, their respective estates, spouses or former spouses with respect to the cancellation, purchase or redemption of Equity Interests of the
Parent, any of its Subsidiaries, or any of the Parent’s direct or indirect parent companies to the extent permitted under Section 4.07(b)(4); 

(19) Indebtedness of the Parent, the Issuers or another Guarantor incurred in connection with or in contemplation of, or to
provide all or any portion of the funds or credit support utilized to consummate, the acquisition by the Parent, the Issuers or such Guarantor of property or license used or useful in a Permitted Business (including a Product or license to a
Product) (whether through the direct purchase of assets or the purchase of Capital Stock of, or merger or consolidation with, any Person owning such assets); provided, however, on the date of such Incurrence and after giving effect thereto on
a pro forma basis, either (a) the Parent would be entitled to Incur at least $1.00 of additional Indebtedness pursuant to the first paragraph of this covenant or (b) the Fixed Charge Coverage Ratio would not be less than such Fixed
Charge Coverage Ratio immediately prior to such acquisition; 
 (20) Indebtedness consisting of obligations under any
Permitted Equity Derivatives; 
 (21) Indebtedness issued in connection with an Investment involving a tender offer followed
by a short form merger, in the form of an intercompany note; provided that the Indebtedness relating thereto is extinguished or retired not later than three Business Days after consummation of the related short form merger (or such
Indebtedness otherwise becomes a Permitted Investment within such time period); and 
 (22) Indebtedness of the Parent or of
any of the Restricted Subsidiaries in an aggregate principal amount on the date of Incurrence that, when taken together with all other Indebtedness of the Parent and the Restricted Subsidiaries then outstanding and Incurred pursuant to this clause
(22), does not exceed the greater of $90.0 million or 2.5% of Total Assets. 
 (c) For purposes of determining compliance with this Section
4.09: 
 (1) all Indebtedness outstanding under the Credit Agreement on the Issue Date will be treated as Incurred under
clause (1) of the immediately preceding paragraph; 
 (2) in the event that an item of Indebtedness (or any portion
thereof) meets the criteria of more than one of the types of Indebtedness described in Section 4.09, the Parent, in its sole discretion, will classify such item of Indebtedness (or any portion thereof) at the time of Incurrence and will only be
required to include the amount and type of such Indebtedness in Section 4.09(a) or one of the clauses of Section 4.09(b) (provided, that any Indebtedness originally classified as Incurred pursuant to any of clauses (2) through (22) of
Section 4.09(b) may later be reclassified as having been Incurred pursuant to Section 4.09(a) or any other of clauses (2) through (22) of Section 4.09(b) to the extent that such reclassified Indebtedness could be Incurred pursuant to Section 4.09(a)
or one of clauses (2) through (22) of Section 4.09(b), as the case may be, if it were Incurred at the time of such reclassification); and 

(3) the Parent will be entitled to divide and classify an item of Indebtedness in more than one of the types of Indebtedness
described in this Section 4.09.

  
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 (d) For purposes of determining compliance with any U.S. dollar-denominated restriction on the
incurrence of Indebtedness, the U.S. dollar-equivalent principal amount of Indebtedness denominated in a foreign currency shall be calculated based on the relevant currency exchange rate in effect on the date such Indebtedness was incurred, in the
case of term debt, or first committed, in the case of revolving credit debt; provided, that, if such Indebtedness is incurred to Refinance other Indebtedness denominated in a foreign currency, and such Refinancing would cause the applicable
U.S. dollar-denominated restriction to be exceeded if calculated at the relevant currency exchange rate in effect on the date of such Refinancing, such U.S. dollar-denominated restriction shall be deemed not to have been exceeded so long as the
principal amount of such Permitted Refinancing Indebtedness does not exceed the principal amount of such Indebtedness being Refinanced (plus accrued interest and premium (including tender premium) thereon, any committed or undrawn amounts associated
with, original issue discount on, and underwriting discounts, fees, commissions and expenses incurred in connection with, such Refinancing).

(e) The principal amount of any Indebtedness incurred to Refinance other Indebtedness, if incurred in a different currency from the
Indebtedness being Refinanced, shall be calculated based on the currency exchange rate applicable to the currencies in which such respective Indebtedness is denominated that is in effect on the date of such Refinancing.

(f) The Parent will not, and will not permit the Issuers or any other Guarantor to, directly or indirectly, incur any Indebtedness (including
Permitted Debt) that is contractually subordinated or junior in right of payment to any Indebtedness of the Parent, the Issuers or such Guarantor, as the case may be, unless such Indebtedness is expressly subordinated in right of payment to the
Notes or the applicable Note Guarantee to the extent and in the same manner as such Indebtedness is subordinated to other Indebtedness of the Parent, the Issuers or such Guarantor, as the case may be; provided, that (i) unsecured
Indebtedness shall not be treated as subordinated or junior to any other Indebtedness merely because it is unsecured and (ii) Indebtedness shall not be treated as subordinated or junior in right of payment to other Indebtedness merely because
such Indebtedness has a junior priority with respect to any collateral. 
 Section 4.10 Asset Sales. 

(a) The Parent will not, and will not permit any of the Restricted Subsidiaries to, consummate an Asset Sale unless: 

(1) the Parent (or the Restricted Subsidiary, as the case may be) receives consideration at the time of the Asset Sale at least
equal to the Fair Market Value (measured as of the date of the definitive agreement with respect to such Asset Sale) of the assets or shares of Capital Stock of a Restricted Subsidiary issued or sold or otherwise disposed of; and 

(2) at least 75% of the consideration received by the Parent or such Restricted Subsidiary is in the form of cash or Cash
Equivalents. For purposes of this provision, each of the following will be deemed to be cash consideration: 
 (A) any
liabilities (as shown on the Parent’s or such Restricted Subsidiary’s most recent balance sheet or in the footnotes thereto) of the Parent or any Restricted Subsidiary (other than liabilities that are by their terms contractually
subordinated to the notes or any Note Guarantee) (i) that are assumed by the transferee of any such assets and for which the Parent or such Restricted Subsidiary, as the case may be, has been released or indemnified against further liability or
(ii) in respect of which neither the Parent nor any Restricted Subsidiary following such Asset Sale has any obligation; 

  
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 (B) any securities, notes or other obligations received by the Parent or any such
Restricted Subsidiary from such transferee that are converted by the Parent or such Restricted Subsidiary within 365 days into cash or Cash Equivalents, to the extent of the cash or Cash Equivalents received in that conversion; 

(C) any Designated Noncash Consideration having an aggregate Fair Market Value that, when taken together with all other
Designated Noncash Consideration previously received and then outstanding, does not exceed at the time of the receipt of such Designated Noncash Consideration (with the Fair Market Value of each item of Designated Noncash Consideration being
measured at the time received and without giving effect to subsequent changes in value) the greater of $75.0 million or 2.0% of Total Assets; and 

(D) any Investment, stock, asset, property or capital expenditure of the kind referred to in Section 4.10(b)(3). 

(b) Within one year from the later of the date of an Asset Sale or the receipt of any Net Proceeds from an Asset Sale, the Parent or any
Restricted Subsidiary may apply such Net Proceeds: 
 (1) to prepay, repay, redeem or purchase (a) Indebtedness and
other Obligations that are secured by a Lien or (b) Indebtedness (other than any Disqualified Stock) and other Obligations of a Non-Guarantor Subsidiary (other than Indebtedness owed to the Parent or any Restricted Subsidiary), and, in each case, if
the Indebtedness repaid is revolving credit Indebtedness, to correspondingly reduce commitments with respect thereto; 
 (2)
to prepay, repay, redeem or purchase Senior Indebtedness of the Parent, the Issuers or any other Guarantor; provided, that, the Parent shall apply not less than a pro rata portion (determined and as modified based on the provisions set forth
below) of such Net Proceeds to (y) redeem or repurchase the Notes (i) as described in Section 3.07 or (ii) through open market purchases at a purchase price not less than 100% of the principal amount thereof, plus accrued but unpaid
interest thereon, or (z) make an offer (in accordance with the procedures set forth below) to all holders to purchase their Notes at a purchase price not less than 100% of the principal amount thereof, plus accrued but unpaid interest thereon to,
but not including, the repurchase date (in each case other than Indebtedness or other Obligations owed to the Parent or an Affiliate of the Parent); or 

(3) to make an Investment in any one or more businesses (provided that, if such Investment is in the form of the
acquisition of Capital Stock of a Person as a result of which such Person becomes a Subsidiary, such Person shall become a Restricted Subsidiary), to acquire assets or property (including the acquisition or license of intellectual property) or to
make capital expenditures, in each case (a) constituting, or used or useful in a Permitted Business or (b) that replace the properties and assets that are the subject of such Asset Sale; 

provided that, in the case of Section 4.10(b)(3), entering into and not abandoning or rejecting a binding commitment to make an Investment, acquire
assets or property or make capital expenditures to satisfy Section 4.10(b)(3) above shall be treated as a permitted application of Net Proceeds from the date of such commitment; provided that (x) such Investment, acquisition or capital
expenditure is consummated within 545 days after the later of the receipt of such Net Proceeds or the date of such Asset Sale and (y) if such 

  
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Investment, acquisition or capital expenditure is not consummated within the period set forth in subclause (x), or otherwise applied as set forth in Section 4.10(b) (1) or (2), the Net Proceeds
not so applied will be deemed to constitute Excess Proceeds under Section 4.10(d). 
 (c) Pending the final application of any Net
Proceeds, the Parent or a Restricted Subsidiary may temporarily reduce revolving credit borrowings or otherwise invest the Net Proceeds in any manner that is not prohibited by this Indenture. 

(d) Any Net Proceeds from Asset Sales that are not applied or invested as provided in Section 4.10(b) will constitute “Excess
Proceeds.” When the aggregate amount of Excess Proceeds exceeds the greater of $75.0 million or 2.0% of Total Assets, within 30 days thereof, the Issuers will make an offer (an “Asset Sale Offer”) to all Holders of Notes
and all Holders of other Senior Indebtedness containing provisions similar to those set forth in this Indenture with respect to offers to purchase, prepay or redeem with the proceeds of sales of assets (provided that the portion of such Asset
Sale Offer made to the Holders of the Notes is not less than a pro rata portion of the Notes taken together with such other Senior Indebtedness) to purchase, prepay or redeem the maximum principal amount of Notes and such other Senior Indebtedness
(plus all accrued interest on the Indebtedness and the amount of all fees and expenses, including premiums, incurred in connection therewith) that may be purchased, prepaid or redeemed out of the Excess Proceeds. The offer price in any Asset Sale
Offer will be equal to 100% of the principal amount (or accreted value, if less, or such lesser amount as may be provided by the terms of such other Senior Indebtedness), plus accrued and unpaid interest to the date of purchase, prepayment or
redemption (subject to the rights of Holders of Notes on the relevant record date to receive interest due on the relevant interest payment date if the Notes have not been redeemed or repurchased prior to such date), and will be payable in cash. If
any Excess Proceeds remain after consummation of an Asset Sale Offer, the Parent or any Restricted Subsidiary may use those Excess Proceeds for any purpose not otherwise prohibited by this Indenture. If the aggregate principal amount of Notes
and other Senior Indebtedness tendered in (or required to be prepaid or redeemed in connection with) such Asset Sale Offer exceeds the amount of Excess Proceeds, the Trustee will select the Notes to be purchased on a pro rata basis, based on the
amounts tendered or required to be prepaid or redeemed (with such adjustments as may be deemed appropriate by the Issuers so that only Notes in denominations of $200,000, or an integral multiple of $1,000 in excess thereof, will be purchased) unless
otherwise required by law or applicable depositary requirements. Upon completion of each Asset Sale Offer, the amount of Excess Proceeds will be reset at zero.

Section 4.11 Transactions with Affiliates. 

(a) The Parent will not, and will not permit any of the Restricted Subsidiaries to, make any payment to or sell, lease, transfer or otherwise
dispose of any of its properties or assets to, or purchase any property or assets from, or enter into or make or amend any transaction, contract, agreement, understanding, loan, or advance with or guarantee for the benefit of, any Affiliate of the
Parent (each, an “Affiliate Transaction”) involving aggregate payments or consideration in excess of $7.5 million, unless: 

(1) the Affiliate Transaction is on terms that are not materially less favorable to the Parent or the relevant Restricted
Subsidiary than those that would have been obtained in a comparable transaction by the Parent or such Restricted Subsidiary with an unrelated Person; and 

(2) the Parent delivers to the trustee with respect to any Affiliate Transaction or series of related Affiliate Transactions
involving aggregate payments or consideration in excess of $45.0 million, a resolution adopted by the Board of Directors of the Parent approving such 

  
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Affiliate Transaction and set forth in an Officer’s Certificate certifying that such Affiliate Transaction has been approved by a majority of the Board of Directors of the Parent and
complies with Section 4.11(a)(1). 
 (b) The following items will not be deemed to be Affiliate Transactions and, therefore, will not be
subject to Section 4.11(a): 
 (1) any employment or consulting agreement, incentive agreement, employee benefit plan,
severance agreement, officer or director indemnification agreement or any similar arrangement entered into by the Parent or any of the Restricted Subsidiaries in the ordinary course of business or approved by the Board of Directors of the Parent and
payments pursuant thereto; 
 (2) transactions between or among the Parent and/or the Restricted Subsidiaries; 

(3) transactions with any Person that is an Affiliate of the Parent solely because the Parent owns, directly or through a
Restricted Subsidiary, an Equity Interest in, or controls, such Person; 
 (4) payment of reasonable fees or other reasonable
compensation to, provision of customary benefits or indemnification agreements to, and the reimbursements of expenses (pursuant to indemnity arrangements or otherwise) of, officers, directors, employees or consultants of the Parent, any of the
Restricted Subsidiaries or any of the Parent’s direct or indirect parent companies; 
 (5) any capital contributions in,
or issuance of Equity Interests (other than Disqualified Stock) of, the Parent; 
 (6) Restricted Payments (or transfers or
issuances that would constitute Restricted Payments but for the exclusions from the definition thereof) that do not violate Section 4.07 hereof and Permitted Investments; 

(7) loans or advances to employees of the Parent, any of its Subsidiaries or any of the Parent’s direct or indirect parent
companies in the ordinary course of business of the Parent or the Restricted Subsidiaries not to exceed $7.5 million in the aggregate at any one time outstanding; 

(8) any agreement as in effect on the Issue Date and described in the Offering Memorandum (or described in a document
incorporated by reference in the Offering Memorandum as of the Issue Date) or any renewals or extensions of any such agreement (so long as such renewals or extensions are not less favorable in any material respect to the Parent or the Restricted
Subsidiaries) and the transactions evidenced thereby; 
 (9) transactions in which the Parent or any Restricted Subsidiary,
as the case may be, delivers to the trustee a letter from an accounting, appraisal or investment banking firm of national standing stating that such transaction meets the requirements of Section 4.11(a)(1); 

(10) transactions with customers, clients, suppliers, or purchasers or sellers of goods or services, in each case in the
ordinary course of business and otherwise in compliance with the terms of this Indenture which are fair to the Parent and the Restricted Subsidiaries, in the reasonable determination of the Board of Directors of the Parent or the senior management


  
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thereof, or are on terms at least as favorable as might reasonably have been obtained at such time from an unaffiliated party (as determined by the Board of Directors of the Parent or the senior
management thereof in good faith); 
 (11) transactions in the ordinary course with (a) Unrestricted Subsidiaries or
(b) joint ventures in which the Parent or a Subsidiary of the Parent holds or acquires an ownership interest (whether by way of Capital Stock or otherwise) so long as the terms of any such transactions are no less favorable to the Parent or any
Subsidiary participating in such joint ventures than they are to other joint venture partners; 
 (12) the existence of, or
the performance by the Parent or any of the Restricted Subsidiaries of its obligations under the terms of, any limited liability company agreement, limited partnership or other organizational documents or stockholders agreement (including any
purchase agreement related thereto) to which it is a party as of the Issue Date and any similar agreements which it may enter into thereafter; provided, however, that the existence of, or the performance by the Parent or any Restricted
Subsidiary of obligations under any future amendment to any such existing agreement or under any similar agreement entered into after such date shall only be permitted by this clause (12) to the extent that the terms of any such amendment or
new agreement, taken as a whole, is no less favorable to the Parent and the Restricted Subsidiaries than the agreement in effect on the Issue Date (as determined by the Board of Directors of the Parent or the senior management thereof in good
faith); 
 (13) the provision of services to directors or officers of the Parent, any of the Restricted Subsidiaries or any
of the Parent’s direct or indirect parent companies of the nature provided by the Parent or any of the Restricted Subsidiaries to customers in the ordinary course of business; 

(14) transactions undertaken in good faith for the purpose of improving the consolidated tax efficiency of the Parent, its
Subsidiaries or the Parent’s direct or indirect parent companies; 
 (15) any Incurrence of Indebtedness permitted by
Section 4.09; 
 (16) the granting of registration and other customary rights in connection with the issuance of Equity
Interests or other securities by the Parent; and 
 (17) the Andromeda Transactions. 

Section 4.12 Liens. 
 The Parent will
not, and will not permit any Restricted Subsidiary to, directly or indirectly, Incur or permit to exist any Lien (the “Initial Lien”) of any nature whatsoever on any of its properties (including Capital Stock of a Restricted
Subsidiary), whether owned at the Issue Date or thereafter acquired, securing any Indebtedness, other than Permitted Liens, without effectively providing that the Notes shall be secured equally and ratably with (or prior to) the obligations so
secured for so long as such obligations are so secured. 
 Any Lien created for the benefit of the Holders of the Notes pursuant to the
preceding sentence shall provide by its terms that such Lien shall be automatically and unconditionally released and discharged upon the release and discharge of the Initial Lien. 

  
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 Section 4.13 Corporate Existence.  

Subject to Articles 5 and 10 (as applicable), each of the Issuers and the Guarantors will do or cause to be done all things necessary to
preserve and keep in full force and effect its corporate or other existence and rights (charter and statutory); provided, however, that the Issuers and the Guarantors shall not be required to preserve any such right if the Issuers or
the Guarantors, as applicable, shall in good faith determine that the preservation thereof is no longer desirable in the conduct of the business of the Issuers or the Guarantors, taken as a whole. 

Section 4.14 Offer to Repurchase Upon Change of Control. 

(a) If a Change of Control occurs, unless the Issuers have previously or concurrently delivered a redemption notice with respect to all the
outstanding Notes pursuant to Section 3.07, within 30 days following such Change of Control, the Issuers will make an Offer to Purchase all of the Notes (a “Change of Control Offer”) on the terms set forth in this Indenture and in
compliance with Section 3.09. In the Change of Control Offer, the Issuers will offer to purchase all of the Notes at a purchase price in cash equal to 101% of the aggregate principal amount of Notes repurchased, plus accrued and unpaid interest on
the Notes repurchased to, but not including, the date of purchase (subject to the rights of holders of Notes on the relevant record date to receive interest due on the relevant interest payment date if the Notes have not been redeemed or repurchased
prior to such date) (the “Change of Control Payment”).
 (b) Notwithstanding anything to the contrary in this Section 4.14,
the Issuers will not be required to make a Change of Control Offer upon a Change of Control if (1) a third party makes the Change of Control Offer in the manner, at the times and otherwise in compliance with the requirements set forth in this
Indenture applicable to a Change of Control Offer made by the Issuers and purchases all Notes properly tendered and not withdrawn under the Change of Control Offer, or (2) notice of redemption has been given pursuant to Section 3.07 under this
Indenture, unless and until there is a default in payment of the applicable redemption price.
 Notwithstanding anything to the contrary
contained herein, a Change of Control Offer may be made in advance of a Change of Control, or conditioned upon the consummation of such Change of Control, if a definitive agreement is in place for the Change of Control at the time the Change of
Control Offer is made.
 Section 4.15 Reserved.  

Section 4.16 Reserved.  
 Section 4.17
Reserved. 
 Section 4.18 Additional Note Guarantees. 

If any direct or indirect Restricted Subsidiary of the Parent that is not a Guarantor (other than an Immaterial Subsidiary or an Issuer)
becomes a guarantor or obligor in respect of any Triggering Indebtedness, within 60 days of such event the Parent will, subject to applicable law, cause such Restricted Subsidiary to enter into a supplemental indenture pursuant to which such
Subsidiary shall agree to Guarantee the Issuers’ Obligations under the Notes, fully and unconditionally and on a senior basis, subject to Section 10.02. The Parent also may, at any time, cause a Subsidiary to become a Guarantor by
executing and delivering a supplemental indenture providing for the Guarantee of payment of the Notes by such Subsidiary on the basis provided in this Indenture. Any such supplemental indenture may be in the form of such supplemental indenture
attached as Exhibit E hereto or such other form as 

  
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agreed between the Issuers, the applicable Guarantor and the Trustee; provided that such supplemental indenture shall include any Applicable Guarantee Limitations (in addition to any such
Applicable Guarantee Limitations set forth in Article 10 hereof) to the extent the Issuers have delivered to the Trustee an Officer’s Certificate certifying that it has been advised by counsel in the applicable jurisdiction of the Guarantor as
to necessity of such Applicable Guarantee Limitations. For the avoidance of doubt, no Opinion of Counsel shall be required to be delivered in respect of the necessity of any Applicable Guarantee Limitations and any Opinion of Counsel delivered
in connection with such supplemental indenture pursuant to Section 9.05 may rely on such Officer’s Certificate as to the necessity of such Applicable Guarantee Limitations. 

If any Guarantor becomes an Immaterial Subsidiary, the Parent shall have the right, by execution and delivery of a supplemental indenture to
the Trustee, to cause such Immaterial Subsidiary to cease to be a Guarantor, subject to the requirement described in the first paragraph above that such Subsidiary shall be required to become a Guarantor if it ceases to be an Immaterial Subsidiary
(except that if such Subsidiary has been properly designated as an Unrestricted Subsidiary it shall not be so required to become a Guarantor or execute a supplemental indenture); provided, further, that such Immaterial Subsidiary shall not be
permitted to Guarantee the Credit Agreement or other Triggering Indebtedness of any Guarantor or the Issuers, unless it again becomes a Guarantor.
 Section
4.19 Designation of Restricted and Unrestricted Subsidiaries. 
 The Parent may designate after the Issue Date any Subsidiary (other
than the Issuers) (including any newly acquired or newly formed Subsidiary) as an “Unrestricted Subsidiary” under this Indenture (a “Designation”) only if: 

(a) no Default or Event of Default has occurred and is continuing after giving effect to such Designation; 

(b) the Subsidiary to be so designated and its Subsidiaries do not at the time of Designation own any Capital Stock or Indebtedness of, or own
or hold any Lien on any Property of, the Parent or any other Subsidiary of the Parent that is not a Subsidiary of the Subsidiary so designated; 

(c) the Subsidiary to be so designated and its Subsidiaries do not at the time of Designation have and do not thereafter Incur any
Indebtedness pursuant to which the lender or other Holder of such Indebtedness has recourse to any of the assets of the Parent or any of the Restricted Subsidiaries; and 

(d) either (x) the Subsidiary to be so designated has total consolidated assets of $1,000 or less or (y) if such Subsidiary has
consolidated assets greater than $1,000, then the Parent could make a Restricted Payment at the time of such Designation in an amount equal to the Fair Market Value of all outstanding Investments owned by the Parent and the Restricted Subsidiaries
in such Subsidiary under Section 4.07 and such amount is thereafter treated as an “Investment” for purposes of calculating the amount of Restricted Payments thereunder. 

The Parent may revoke any Designation of a Subsidiary as an Unrestricted Subsidiary (a “Revocation”) only if, immediately
after giving effect such Revocation: 
 (e) (x) the Parent could Incur at least $1.00 of additional Indebtedness under Section 4.09(a) or
(y) the Fixed Charge Coverage Ratio would not be less than immediately prior to such Revocation, in each case on a pro forma basis taking into account such Revocation; 

  
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 (f) all Liens of such Unrestricted Subsidiary outstanding immediately following such Revocation
would, if Incurred at such time, have been permitted to be Incurred for all purposes of this Indenture; and 
 (g) no Default or Event of
Default has occurred and is continuing after giving effect to such Revocation. 
 Each Designation and Revocation must be evidenced by
promptly delivering to the Trustee a board resolution of the Board of Directors of the Parent giving effect to such Designation or Revocation, as the case may be, and an Officer’s Certificate certifying compliance with the preceding
provisions. A Revocation will be deemed to be an Incurrence of Indebtedness by a Restricted Subsidiary of any outstanding Indebtedness of such Unrestricted Subsidiary. 

Section 4.20 Suspension of Covenants When Notes Rated Investment Grade 

(a) If on any date following the Issue Date, the Notes are rated Baa3 or better by Moody’s and BBB- or better by S&P
(“Investment Grade Status”) (or, if either such entity ceases to rate such notes for reasons outside of the control of the Parent, the equivalent investment grade credit rating from any other “nationally recognized statistical
rating organization” within the meaning of Section 3(a)(62) of the Exchange Act selected by the Parent as a replacement agency) then, beginning on that day and continuing until the Reversion Date (as defined below), the Parent and the
Restricted Subsidiaries will not be subject to Sections 4.07, 4.08, 4.09, 4.10, 4.11, 4.18 and 4.19 and clause (a)(4) of Section 5.01 of this Indenture (collectively, the “Suspended Covenants”). 

(b) If any time the Notes cease to have such Investment Grade Status, then the Suspended Covenants will thereafter be reinstated as if such
covenants had never been suspended (the “Reversion Date”) and be applicable pursuant to the terms of this Indenture (including in connection with performing any calculation or assessment to determine compliance with the terms of
this Indenture), unless and until the Notes subsequently attain Investment Grade Status (in which event the Suspended Covenants shall no longer be in effect for such time that the Notes maintain an Investment Grade Status); provided,
however, that no Default, Event of Default or breach of any kind shall be deemed to exist under this Indenture, the Notes or the Note Guarantees with respect to the Suspended Covenants based on, and none of the Parent or any of its
Subsidiaries shall bear any liability for, any actions taken or events occurring during the Suspension Period (as defined below), or any actions taken at any time pursuant to any contractual obligation arising prior to the Reversion Date, regardless
of whether such actions or events would have been permitted if the applicable Suspended Covenants remained in effect during such period. The period of time between the date of suspension of the covenants and the Reversion Date is referred to as
the “Suspension Period.” 
 (c) On the Reversion Date, all Indebtedness Incurred during the Suspension Period will be
classified to have been Incurred pursuant to Section 4.09(a) (to the extent such Indebtedness would be permitted to be Incurred thereunder as of the Reversion Date and after giving effect to the Indebtedness Incurred prior to the Suspension Period
and outstanding on the Reversion Date). To the extent such Indebtedness would not be so permitted to be incurred pursuant to Section 4.09(a), such Indebtedness will be deemed to have been outstanding on the Issue Date, so that it is classified
as permitted under clause (4) of Section 4.09(b). Calculations made after the Reversion Date of the amount available to be made as Restricted Payments under Section 4.07 will be made as though Section 4.07 had been in effect since the
Issue Date and throughout the Suspension Period; provided that, no Subsidiaries may be designated as Unrestricted Subsidiaries during the Suspension Period, unless such designation would have complied with Section 4.07 as if such
covenant would have been in effect during such period. Accordingly, Restricted Payments made during the Suspension Period will reduce the amount available to be made as 

  
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Restricted Payments under Section 4.07(a). During the Suspension Period, any future obligation to grant further Note Guarantees shall be suspended. All such further obligation to grant
Note Guarantees shall be reinstated upon the Reversion Date. 
 (d) The Trustee shall have no duty to monitor the ratings of the Notes,
shall not be deemed to have any knowledge of the ratings of the Notes and shall have no duty to notify Holders if the Notes achieve Investment Grade Status or of the occurrence of a Reversion Date. The Issuers shall provide written notice to
the Trustee of the commencement or end, as applicable, of a Suspension Period. 
 Section 4.21 Additional Amounts  

All payments made by or on behalf of the Issuers or any of the Guarantors under or with respect to the Notes or any Note Guarantee will be
made without withholding or deduction for, or on account of, any present or future Taxes unless the withholding or deduction of such Taxes is then required by law. If any deduction or withholding for, or on account of, any Taxes imposed or
levied by or on behalf of (1) any jurisdiction in which the Issuers or any Guarantor (including any successor entity) is then incorporated, organized, engaged in business or resident for tax purposes or any political subdivision or Governmental
Authority thereof or therein or (2) any jurisdiction from or through which payment is made by or on behalf of the Issuers or any Guarantor (including, without limitation, the jurisdiction of any Paying Agent) or any political subdivision or
Governmental Authority thereof or therein (each of (1) and (2), a “Tax Jurisdiction”) will at any time be required to be made from any payments under or with respect to the Notes or any Note Guarantee, including, without
limitation, payments of principal, redemption price, purchase price, interest or premium, the Issuers or the relevant Guarantor, as applicable, will pay such additional amounts (the “Additional Amounts”) as may be necessary in order
that the net amounts received and retained in respect of such payments by each beneficial owner of Notes after such withholding or deduction by any applicable withholding agent will equal the amounts that would have been received and retained in
respect of such payments in the absence of such withholding or deduction; provided, however, that no Additional Amounts will be payable with respect to: 

(a) any Taxes, to the extent such Taxes would not have been imposed but for the Holder or the beneficial owner of the Notes being a citizen or
resident or national of, being incorporated in or having any other present or former connection with the relevant Tax Jurisdiction other than the acquisition or holding of any Note, the exercise or enforcement of rights under any Note or this
Indenture or any Note Guarantee or the receipt of any payment in respect of any Note or Note Guarantee; 
 (b) any Taxes, to the extent such
Taxes were imposed as a result of the presentation of a Note for payment (where presentation is required) more than 30 days after the relevant payment is first made available for payment to the Holder (except to the extent that the Holder would have
been entitled to Additional Amounts had the Note been presented on the last day of such 30 day period); 
 (c) any estate, inheritance,
gift, sale, transfer or similar Taxes; 
 (d) any Taxes required to be withheld or deducted as a result of the presentation of any Note for
payment (where presentation is required) by or on behalf of a Holder of Notes who would have been able to avoid such withholding or deduction by presenting the relevant Note to another Paying Agent designated by the Issuers under this Indenture;

 (e) any Taxes required to be paid other than by deduction or withholding from payments under, or with respect to, the Notes or any Note
Guarantee; 

  
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 (f) any Taxes to the extent such Taxes are imposed or withheld by reason of the failure of the
Holder or beneficial owner of Notes, following the Issuers’ reasonable written request addressed to the Holder or beneficial owner at least 60 days before any such withholding or deduction would be payable, to comply with any certification,
identification, information or other reporting requirements, whether required by statute, treaty, regulation or administrative practice of a Tax Jurisdiction, as a precondition to exemption from, or reduction in the rate of deduction or withholding
of, Taxes imposed by the Tax Jurisdiction, but in each case, only to the extent the Holder or beneficial owner is legally eligible to comply with such requirements; 

(g) any Taxes imposed or withheld by reason of the failure of the Holder or beneficial owner of the Notes to comply with the requirements of
Sections 1471 through 1474 of the Code, as of the Issue Date (or any amended or successor version that is substantively comparable and not materially more onerous to comply with), the U.S. Treasury Regulations issued thereunder or any official
interpretation thereof or any agreement entered into pursuant to Section 1471(b) of the Code, as of the Issue Date (or any amended or successor provision described above); 

(h) any withholding Tax imposed by the United States or a political subdivision thereof; 

(i) any Taxes imposed on or with respect to any payment by the Issuers or any Guarantor to the Holder if such Holder is a fiduciary,
partnership, limited liability company or person other than the sole beneficial owner of such payment to the extent that such Taxes would not have been imposed had such Holder been the sole beneficial owner of the applicable Notes; 

(j) any Taxes withheld in Luxembourg, deducted or imposed on a payment to an individual and that are required to be made pursuant to the law
of 23 December 2005 introducing a final withholding tax on saving income in favor of beneficiaries who are individuals resident in Luxembourg; or 

(k) any combination of clauses (a) through (j) above. 

In addition to the foregoing, the Issuers and the Guarantors will also pay and indemnify the Holder for any present or future stamp, issue,
registration, value added, transfer, court or documentary Taxes, or any other excise or property Taxes, charges or similar levies (including penalties, interest and any other liabilities related thereto) which are levied by any Tax Jurisdiction on
the execution, delivery, issuance, or registration of any of the Notes, this Indenture, any Note Guarantee or any other document referred to therein, or the receipt of any payments with respect thereto, or the enforcement of any Note or Note
Guarantee. 
 If the Issuers or any Guarantor, as the case may be, becomes aware that it will be obligated to pay Additional Amounts with
respect to any payment under or with respect to the Notes or any Note Guarantee, the Issuers or the relevant Guarantor, as the case may be, will deliver to the Trustee on a date that is at least 30 days prior to the date of that payment (unless the
obligation to pay Additional Amounts arises after the 30th day prior to that payment date, in which case the Issuers or the relevant Guarantor shall notify the Trustee promptly thereafter) an Officer’s Certificate stating the fact that
Additional Amounts will be payable and the amount estimated to be so payable. The Officer’s Certificate must also set forth any other information reasonably necessary to enable the Paying Agents to pay Additional Amounts on the relevant
payment date. The Trustee shall be entitled to rely on an Officer’s Certificate as conclusive proof that such payments are necessary. The Issuers or the relevant Guarantor will provide the Trustee with documentation reasonably
satisfactory to the Trustee evidencing the payment of Additional Amounts. 

  
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 The Issuers or the relevant Guarantor will make all withholdings and deductions (within the time
period and in the minimum amount) required by law and will remit the full amount deducted or withheld to the relevant Tax authority in accordance with applicable law. The Issuers or the relevant Guarantor will use its reasonable efforts to obtain
Tax receipts from each Tax authority evidencing the payment of any Taxes so deducted or withheld. Upon request, the Issuers or the relevant Guarantor will furnish to the Trustee (or to a Holder upon request), within 60 days after the date the
payment of any Taxes so deducted or withheld is made, certified copies of Tax receipts evidencing payment by the Issuers or such Guarantor, as the case may be, or if, notwithstanding such entity’s efforts to obtain receipts, receipts are not
obtained, other evidence of payments (reasonably satisfactory to the Trustee) by such entity.
 Whenever in this Indenture or the Notes
there is mentioned, in any context, the payment of amounts based upon the principal amount of the Notes or of principal, interest or of any other amount payable under, or with respect to, any of the Notes or any Note Guarantee, such mention shall be
deemed to include mention of the payment of Additional Amounts to the extent that, in such context, Additional Amounts are, were or would be payable in respect thereof.

The above obligations will survive any termination, defeasance or discharge of this Indenture and any transfer by a Holder or Beneficial Owner
of its Notes, and will apply, mutatis mutandis, to any jurisdiction in which any successor Person to the Issuers or any Guarantor is incorporated, organized, engaged in business or resident for tax purposes, any jurisdiction from or through which
payment is made by or on behalf of such Person, and, in each case, any political subdivision or governmental authority thereof or therein. 

ARTICLE 5 
 SUCCESSORS 

Section 5.01 Merger, Consolidation or Sale of Assets. 

(a) The Parent will not: (1) consolidate with or merge or amalgamate with or into another Person (whether or not the Parent is the surviving
Person), or (2) directly or indirectly, sell, assign, transfer, convey, lease or otherwise dispose of all or substantially all of the assets of the Parent and the Restricted Subsidiaries taken as a whole, in one or more related transactions, to
another Person, unless: 
 (1) either: 

(a) the Parent is the surviving Person; or 

(b) the Person formed by or surviving any such consolidation, amalgamation or merger (if other than the Parent) or to which
such sale, assignment, transfer, conveyance, lease or other disposition has been made is an entity organized or existing under the laws of the United States, any state of the United States or the District of Columbia, Luxembourg, Bermuda or Ireland;

 (2) the Person formed by or surviving any such consolidation, amalgamation or merger (if other than the Parent) or the
Person to which such sale, assignment, transfer, conveyance, lease or other disposition has been made assumes all the obligations of the Parent under the Note Guarantee and this Indenture pursuant to a supplemental indenture; 

(3) immediately after such transaction, no Default or Event of Default exists; 

  
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 (4) the Parent or the Person formed by or surviving any such consolidation,
amalgamation or merger (if other than the Parent), or to which such sale, assignment, transfer, conveyance, lease or other disposition has been made would, on the date of such transaction after giving pro forma effect thereto and any related
financing transactions as if the same had occurred at the beginning of the applicable four-quarter period, (a) be permitted to incur at least $1.00 of additional Indebtedness pursuant to the Fixed Charge Coverage Ratio test set forth in Section
4.09(a); or (ii) have had a Fixed Charge Coverage Ratio not less than the actual Fixed Charge Coverage Ratio for such four-quarter period; and 

(5) the Parent shall have delivered to the trustee an Officer’s Certificate and an Opinion of Counsel, each stating that
such consolidation, merger or transfer and such supplemental indenture (if any) comply with this Indenture. 
 (b) The Issuers shall not
consolidate or merge with or into another Person (whether or not the Company or the Co-Issuer, as applicable, is the surviving Person) unless: 

(1) either: (a) the Company or the Co-Issuer is the surviving Person; or (b) the Person formed by or surviving any such
consolidation or merger (if other than an Issuer) or to which such sale, assignment, transfer, conveyance, lease or other disposition has been made is an entity organized or existing under the laws of the United States, any state of the United
States or the District of Columbia, Luxembourg, Bermuda or Ireland; and, if such entity is not a corporation, a co-obligor of the Notes is a corporation organized or existing under any such laws; 

(2) the Person formed by or surviving any such consolidation or merger (if other than an Issuer) or the Person to which such
sale, assignment, transfer, conveyance, lease or other disposition has been made assumes all the obligations of the Issuers under the Notes and this Indenture pursuant to a supplemental indenture; and 

(3) immediately after such transaction, no Default or Event of Default exists 

This Section 5.01 will not apply to any sale, assignment, transfer, conveyance, lease or other disposition of assets between or among the
Parent and the Restricted Subsidiaries. Sections 5.01(a)(3) and (4) will not apply to any merger, amalgamation or consolidation of the Parent (1) with or into one of the Restricted Subsidiaries for any purpose or (2) with or into an
Affiliate solely for the purpose of reincorporating the Parent in another jurisdiction. Section 5.01(b) will not apply to any merger or consolidation of any Issuer (1) with or into one of the Restricted Subsidiaries for any purpose so long as
the surviving Person becomes a primary obligor of the Notes or (2) with or into an Affiliate solely for the purpose of reorganizing such Issuer in another jurisdiction so long as the surviving Person becomes a primary obligor of the Notes;
provided, however, if such Person is not a corporation, a co-obligor of the Notes is a corporation organized or existing under the laws of the United States, any state of the United States or the District of Columbia, Luxembourg, Bermuda or
Ireland. 
 The Person formed by or surviving any such consolidation, amalgamation or merger (if other than the Parent or an Issuer) or the
Person to which such sale, assignment, transfer, conveyance, lease or other disposition has been made will be the successor to the Parent or the applicable Issuer and shall succeed to, and be substituted for, and may exercise every right and power
of, the Parent or the applicable Issuer, as the case may be, under this Indenture, and the Parent or the applicable Issuer, except in the case of a lease, shall be released from the obligation to pay the principal of and interest on the Notes. 

  
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 Section 5.02 Successor Corporation Substituted. 

Upon any consolidation or merger, or any sale, assignment, transfer, lease, conveyance or other disposition of all or substantially all of the
properties or assets of the Company in a transaction that is subject to, and that complies with the provisions of, Section 5.01 hereof, the successor Person formed by or surviving any such consolidation, amalgamation or merger (if other than the
Parent or the Issuers) or the Person to which such sale, assignment, transfer, conveyance, lease or other disposition is made shall succeed to, and be substituted for, and may exercise every right and power of the Parent or the Issuers, as the case
may be, under this Indenture and the Parent or the Issuers, except in the case of a lease, shall be released from the obligation to pay the principal of, premium on, if any, and interest on, the Notes. 

ARTICLE 6 
 DEFAULTS AND REMEDIES

 Section 6.01 Events of Default. 

Each of the following is an “Event of Default”: 

(1) default for 30 days in the payment when due of interest on the Notes; 

(2) default in the payment when due (at maturity, upon redemption or otherwise) of the principal of, or premium, if any, on the
Notes; 
 (3) failure by the Parent or any of the Restricted Subsidiaries to comply with any of the other agreements in this
Indenture (other than a failure that is the subject of clause (1) or (2)) for 60 days after receipt by the Parent of written notice of such failure from the Trustee (or receipt by the Parent and the Trustee of written notice of such
failure from the Holders of at least 25% in aggregate principal amount of the Notes then outstanding voting as a single class); 

(4) one or more defaults shall have occurred under any of the agreements, indentures or instruments under which the Parent, any
Issuer or any Significant Subsidiary has outstanding Indebtedness in excess of $50.0 million, individually or in the aggregate, and either (a) such default results from the failure to pay such Indebtedness at its stated final maturity and such
default has not been cured or the Indebtedness repaid in full within 60 days of the default or (b) such default or defaults have resulted in the acceleration of the maturity of such Indebtedness and such acceleration has not been rescinded or
such Indebtedness repaid in full within 60 days of the acceleration; 
 (5) one or more final and nonappealable judgments or
orders that exceed $50.0 million in the aggregate (net of amounts covered by insurance or bonded) for the payment of money have been entered by a court or courts of competent jurisdiction against the Parent, any Issuer or any Significant Subsidiary
and such judgment or judgments are not satisfied, stayed, annulled or rescinded for 60 days; 
 (6) any Note Guarantee by the
Parent or a Significant Subsidiary shall for any reason cease to be, or shall for any reason be held in any judicial proceeding not to be, or asserted in writing by the Parent or such Significant Subsidiary not to be, in full force and effect and
enforceable in accordance with its terms, except to the extent contemplated by this Indenture and any such Note Guarantee, and any such default continues for 10 days; 

(7) the Parent, any Issuer or any Significant Subsidiary:

(A) commences a voluntary insolvency proceeding, 

  
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 (B) consents to the entry of an order for relief against it in an involuntary
insolvency proceeding, 
 (C) consents to the appointment of a Bankruptcy Custodian of it or for all or substantially all of
its property, or 
 (D) makes a general assignment for the benefit of its creditors; 

provided, however, that the liquidation of any Restricted Subsidiary into another Restricted Subsidiary, other than as part of a credit
reorganization, shall not constitute an Event of Default under this Section 6.01(7); and 
 (8) a court of competent
jurisdiction enters an order or decree under any Bankruptcy Law that: 
 (A) is for relief against the Parent, any Issuer or
any Significant Subsidiary in an involuntary insolvency proceeding; 
 (B) appoints a Bankruptcy Custodian of the Parent, the
Issuers or any Significant Subsidiary for all or substantially all of the property of the Parent, the Issuers or any Significant Subsidiary; or 

(C) orders the liquidation of the Parent, the Issuers or any Significant Subsidiary; 

and the order or decree remains unstayed and in effect for 90 consecutive days. 

Section 6.02 Acceleration. 
 If there is
a continuing Event of Default (other than an Event of Default specified in Sections 6.01(7) and 6.01(8) hereof with respect to the Parent or the Issuer) with respect to the Notes, either the Trustee or the Holders of at least 25% of the outstanding
principal amount of the Notes may declare the principal amount of all of the Notes to be due and payable immediately. However, at any time after the Trustee or the Holders, as the case may be, declare an acceleration with respect to the Notes, but
before the applicable person has obtained a judgment or decree based on such acceleration, the Holders of a majority in principal amount of the outstanding notes may, under certain conditions, cancel such acceleration if the Parent has cured all
Events of Default (other than the nonpayment of accelerated principal) with respect to the Notes or all such Events of Default have been waived as provided in this Indenture. If an Event of Default specified in Sections 6.01(7) and 6.01(8) hereof
with respect to the Parent or any Issuer occurs, all outstanding Notes shall become due and payable without any further action or notice. 

Notwithstanding the foregoing, to the extent the Issuers elect, the sole remedy for an Event of Default relating to the Parent’s failure
to comply with the obligations as set forth under Section 4.03, will for the first 270 days after the occurrence of such an Event of Default, consist exclusively of the right to receive additional interest on the Notes (1) at a rate equal to
0.25% per annum of the principal amount of the Notes outstanding for each day during the first 90 days after the occurrence of such an Event of Default during which such event of default is continuing and (2) at a rate equal to
0.50% per annum of the principal amount of the Notes outstanding from the 91st day until the 270th day following the occurrence 

  
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of such event of default during which such event of default is continuing. If the Issuers so elect, such additional interest will be payable in the same manner and on the same dates as the stated
interest payable on the Notes. On the 270th day after the occurrence of the Event of Default (if the Event of Default relating to the reporting obligations is not cured or waived prior to such 270th day), the Notes will be subject to acceleration as
provided above. The provisions of this Indenture described in this paragraph will not affect the rights of Holders of Notes in the event of the occurrence of any other Event of Default. In the event the Issuers do not elect to pay the additional
interest following an Event of Default in accordance with this paragraph and the immediately following paragraph (or the Issuers elect to make such payment but does not pay the additional interest when due), the Notes will be subject to acceleration
as provided above. In no event shall additional interest payable pursuant to the foregoing election accrue at a rate per year in excess of 0.50% per annum, regardless of the number of events or circumstances giving rise to requirements to pay such
additional interest pursuant to this paragraph. 
 In order to elect to pay the additional interest in the immediately preceding paragraph
as the sole remedy during the first 270 days after the occurrence of an Event of Default relating to the Parent’s failure to comply with the obligations as set forth under Section 4.03, the Issuers must notify all Holders, the Trustee and the
Paying Agent (if other than the Trustee) in writing of such election prior to the beginning of such 270-day period. Upon the Issuers’ failure to timely give such notice, the Notes will be immediately subject to acceleration as provided in the
first paragraph of this Section 6.02. 
 Section 6.03 Other Remedies. 

If an Event of Default occurs and is continuing, the Trustee may pursue any available remedy to collect the payment of principal of, premium
on, if any, or interest on, the Notes or to enforce the performance of any provision of the Notes or this Indenture. 
 The Trustee may
maintain a proceeding even if it does not possess any of the Notes or does not produce any of them in the proceeding. A delay or omission by the Trustee or any Holder of a Note in exercising any right or remedy accruing upon an Event of Default
shall not impair the right or remedy or constitute a waiver of or acquiescence in the Event of Default. All remedies are cumulative to the extent permitted by law. 

Subject to the duties of the Trustee to act with the required standard of care, if there is a continuing Event of Default, the Trustee need
not exercise any of its rights or powers under this Indenture at the written request or direction of any of the Holders of Notes, unless such Holders have offered to the Trustee security or indemnity satisfactory to the Trustee. Subject to such
provisions for security or indemnification of the Trustee and certain other conditions, the Holders of a majority in principal amount of the outstanding Notes will have the right to direct the time, method and place of conducting any proceeding for
any remedy available to the Trustee or exercising any trust or power the Trustee holds with respect to the Notes. 
 Section 6.04 Waiver of Past
Defaults 
 The Holders of a majority in aggregate principal amount of the then outstanding Notes by written notice to the Trustee may,
on behalf of the Holders of all of the Notes waive any existing Default or Event of Default and its consequences hereunder, except a continuing Default or Event of Default in the payment of principal of, premium on, if any, or interest on, the
Notes; provided, however, that the Holders of a majority in aggregate principal amount of the then outstanding Notes may rescind an acceleration and its consequences, including any related payment default that resulted from such acceleration.
Upon any such waiver, such Default shall cease to exist, and any Event of Default arising therefrom shall be deemed to have been cured for every purpose of this Indenture; but no such waiver shall extend to any subsequent or other Default or impair
any right consequent thereon. 

  
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 Section 6.05 Control by Majority. 

Holders of a majority in aggregate principal amount of the then outstanding Notes may direct the time, method and place of conducting any
proceeding for exercising any remedy available to the Trustee. However, the Trustee may refuse to follow any direction that conflicts with law or this Indenture or that the Trustee determines may be unduly prejudicial to the rights of other
Holders of Notes or that may involve the Trustee in personal liability. 
 Section 6.06 Limitation on Suits. 

No Holder of any Note will have any right to institute any proceeding with respect to this Indenture or for any remedy unless: 

(a) the Trustee has failed to institute such proceeding for 60 days after the Holder has previously given to the Trustee written notice of a
continuing Event of Default with respect to the Notes; 
 (b) the Holders of at least 25% in principal amount of the then outstanding Notes
have made a written request to the trustee, and offered indemnity or security satisfactory to the Trustee, to institute such proceeding as trustee; and 

(c) the Trustee has not received from the Holders of a majority in principal amount of the outstanding Notes a direction inconsistent with
such request. 
 Section 6.07 Rights of Holders of Notes to Receive Payment. 

Notwithstanding any other provision of this Indenture, the Holder of any Note will have an absolute and unconditional right to institute suit
for the enforcement of any payment of the principal of, and any premium on, if any, or interest on such Note, on or after the date or dates they are to be paid as expressed in such Note. 

Section 6.08 Collection Suit by Trustee. 

If an Event of Default in payment of principal, premium or interest specified in Section 6.01(1) or (2) hereof occurs and is continuing, the
Trustee may recover judgment in its own name and as trustee of an express trust against the Company (or any other obligor on the Notes) for the whole amount of unpaid principal and accrued interest remaining unpaid.

Section 6.09 Trustee May File Proofs of Claim. 

The Trustee is authorized to file such proofs of claim and other papers or documents as may be necessary or advisable in order to have the
claims of the Trustee (including any claim for the compensation (as agreed in writing by the Issuers and the Trustee), expenses, disbursements and advances of the Trustee, its agents and counsel) and the Holders of the Notes allowed in any judicial
proceedings relative to the Issuers (or any other obligor upon the Notes), its creditors or its property and shall be entitled and empowered to collect, receive and distribute any money or other property payable or deliverable on any such claims and
any custodian in any such judicial proceeding is hereby authorized by each Holder to make such payments to the Trustee, and in the event that the Trustee shall consent to the making of such payments directly to the Holders, to pay to the Trustee any
amount due to it for the 

  
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compensation(as agreed in writing by the Issuers and the Trustee), expenses, disbursements and advances of the Trustee, its agents and counsel, and any other amounts due the Trustee under this
Indenture. To the extent that the payment of any such compensation, expenses, disbursements and advances of the Trustee, its agents and counsel, and any other amounts due the Trustee under this Indenture out of the estate in any such
proceeding, shall be denied for any reason, payment of the same shall be secured by a Lien on, and shall be paid out of, any and all distributions, dividends, money, securities and other properties that the Holders may be entitled to receive in such
proceeding whether in liquidation or under any plan of reorganization or arrangement or otherwise. Nothing herein contained shall be deemed to authorize the Trustee to authorize or consent to or accept or adopt on behalf of any Holder any plan
of reorganization, arrangement, adjustment or composition affecting the Notes or the rights of any Holder, or to authorize the Trustee to vote in respect of the claim of any Holder in any such proceeding. 

Section 6.10 Priorities. 
 If the Trustee
collects any money pursuant to this Article 6, it shall pay out the money in the following order: 
 First: to the
Trustee, its agents and attorneys for amounts due under this Indenture, including payment of all compensation, expenses and liabilities incurred (including attorney’s fees), and all advances made, by the Trustee and the costs and expenses of
collection; 
 Second: to Holders of Notes for amounts due and unpaid on the Notes for principal, premium, if any, and
interest, ratably, without preference or priority of any kind, according to the amounts due and payable on the Notes for principal, premium, if any, and interest, respectively; and 

Third: to the Issuers or to such party as a court of competent jurisdiction shall direct. 

The Trustee may fix a record date and payment date for any payment to Holders of Notes pursuant to this Section 6.10. 

Section 6.11 Undertaking for Costs. 
 In
any suit for the enforcement of any right or remedy under this Indenture or in any suit against the Trustee for any action taken or omitted by it as a Trustee, a court in its discretion may require the filing by any party litigant in the suit of an
undertaking to pay the costs of the suit, and the court in its discretion may assess reasonable costs, including reasonable attorneys’ fees and expenses, against any party litigant in the suit, having due regard to the merits and good faith of
the claims or defenses made by the party litigant. This Section 6.11 does not apply to a suit by the Trustee, a suit by a Holder of a Note pursuant to Section 6.07 hereof, or a suit by Holders of more than 10% in aggregate principal amount of
the then outstanding Notes. 
 ARTICLE 7 

TRUSTEE 
 Section 7.01 Duties of Trustee.

 (a) If an Event of Default has occurred and is continuing, the Trustee will exercise such of the rights and powers expressly vested in it
by this Indenture, and use the same degree of care and skill in its exercise, as a prudent person would exercise or use under the circumstances in the conduct of such person’s own affairs. 

  
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 (b) Except during the continuance of an Event of Default: 

(1) the duties of the Trustee will be determined solely by the express provisions of this Indenture and the Trustee need
perform only those duties that are specifically set forth in this Indenture and no others, and no implied covenants or obligations shall be read into this Indenture against the Trustee; and 

(2) in the absence of bad faith on its part, the Trustee may conclusively rely, as to the truth of the statements and the
correctness of the opinions expressed therein, upon certificates or opinions furnished to the Trustee and conforming to the requirements of this Indenture. However, the Trustee will examine the certificates and opinions to determine whether or not
they conform to the requirements of this Indenture (but need not confirm or investigate the accuracy of mathematical calculations or other facts stated therein). 

(c) The Trustee may not be relieved from liabilities for its own negligent action, its own negligent failure to act, or its own willful
misconduct, except that: 
 (1) this paragraph does not limit the effect of paragraph (b) of this Section 7.01; 

(2) the Trustee will not be liable for any error of judgment made in good faith, by a Responsible Officer, unless it is proved
that the Trustee was negligent in ascertaining the pertinent facts; and 
 (3) the Trustee will not be liable with respect to
any action it takes or omits to take in good faith in accordance with a direction received by it under this Indenture. 
 (d) Whether or not
therein expressly so provided, every provision of this Indenture that in any way relates to the Trustee is subject to paragraphs (a), (b), and (c) of this Section 7.01. 

(e) No provision of this Indenture will require the Trustee to expend or risk its own funds or incur any liability. The Trustee will be
under no obligation to exercise any of its rights and powers under this Indenture at the request of any Holders, unless such Holder has offered to the Trustee security and indemnity satisfactory to it against any loss, liability or expense. 

(f) The Trustee will not be liable for interest on any money received by it except as the Trustee may agree in writing with the
Issuer. Money held in trust by the Trustee need not be segregated from other funds except to the extent required by law. 
 Section 7.02 Rights of
Trustee. 
 (a) The Trustee may conclusively rely upon any document believed by it to be genuine and to have been signed or presented by
the proper Person. The Trustee need not investigate any fact or matter stated in the document. 
 (b) Before the Trustee acts or
refrains from acting, it may require an Officer’s Certificate or an Opinion of Counsel or both. The Trustee will not be liable for any action it takes or omits to take in good faith in reliance on such Officer’s Certificate or Opinion
of Counsel. The Trustee may consult with counsel and the advice of such counsel or any Opinion of Counsel will be full and complete authorization and protection from liability in respect of any action taken, suffered or omitted by it hereunder in
good faith and in reliance thereon. 

  
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 (c) The Trustee may act through its attorneys and agents and will not be responsible for the
misconduct or negligence of any agent appointed with due care. 
 (d) The Trustee will not be liable for any action it takes or omits to
take in good faith that it believes to be authorized or within the rights or powers conferred upon it by this Indenture. 
 (e) Unless
otherwise specifically provided in this Indenture, any demand, request, direction or notice from the Issuers will be sufficient if signed by an Officer of the Issuer. 

(f) The Trustee will be under no obligation to exercise any of the rights or powers under this Indenture at the request of any Holders of
Notes unless such Holders have offered to the Trustee indemnity or security satisfactory to it against any losses, liabilities or expenses. 

(g) In no event shall the Trustee be responsible or liable for special, indirect, punitive or consequential loss or damage of any kind
whatsoever (including, but not limited to, loss of profit) irrespective of whether the Trustee has been advised of the likelihood of such loss or damage and regardless of the form of action. 

(h) The Trustee shall not be deemed to have notice of any Default or Event of Default unless a Responsible Officer of the Trustee has actual
knowledge thereof or unless written notice of any event which is in fact such a default is received by the Trustee at the Corporate Trust Office of the Trustee, and such notice references the Notes and this Indenture. 

(i) The Trustee may request that the Issuers deliver a certificate setting forth the names of individuals and/or titles of officers authorized
at such time to take specified actions pursuant to this Indenture. 
 (j) The rights, privileges, protections, immunities and benefits given
to the Trustee, including, without limitation, its right to be indemnified, are extended to, and shall be enforceable by, the Trustee in each of its capacities hereunder, and each agent, custodian and other Person employed to act hereunder. 

(k) The Trustee shall not be required to give any bond or surety in respect of the performance of its powers and duties hereunder. 

(l) The permissive right of the Trustee to take the actions permitted by this Indenture shall not be construed as an obligation or duty to do
so. 
 Section 7.03 Individual Rights of Trustee. 

The Trustee in its individual or any other capacity may become the owner or pledgee of Notes and may otherwise deal with the Company or any
Affiliate of the Company with the same rights it would have if it were not Trustee. If the Trustee becomes a creditor of any of the Issuers or any Guarantor, this Indenture limits the right of the Trustee to obtain payment of claims in certain
cases, or to realize on certain property received in respect of any such claim as security or otherwise. The Trustee will be permitted to engage in other transactions; however, if it acquires any conflicting interest it must eliminate such
conflict within 90 days. Any Agent may do the same with like rights and duties. The Trustee is also subject to Section 7.09 hereof. 

  
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 Section 7.04 Trustee’s Disclaimer. 

The Trustee will not be responsible for and makes no representation as to the validity or adequacy of this Indenture or the Notes, it shall
not be accountable for the Issuers’ use of the proceeds from the Notes or any money paid to the Issuers or upon the Issuers’ direction under any provision of this Indenture, it will not be responsible for the use or application of any
money received by any Paying Agent other than the Trustee, acting in such capacity, and it will not be responsible for any statement or recital herein or any statement in the Notes or any other document in connection with the sale of the Notes or
pursuant to this Indenture other than its certificate of authentication. 
 Section 7.05 Notice of Defaults. 

If a Default or Event of Default occurs and is continuing and if it is known to the Trustee, the Trustee will deliver to Holders of Notes a
notice of the Default or Event of Default within 90 days after it occurs. Except in the case of a Default or Event of Default in payment of principal of, premium on, if any, or interest, on, any Note, the Trustee may withhold the notice if and
so long as it in good faith determines that withholding the notice is in the interests of the Holders of the Notes. 
 Section 7.06 Compensation and
Indemnity. 
 (a) The Issuers will pay to the Trustee from time to time compensation, as agreed in writing between the Issuers and the
Trustee, for its acceptance of this Indenture and services hereunder. The Trustee’s compensation will not be limited by any law on compensation of a trustee of an express trust. The Issuers will reimburse the Trustee promptly upon
request for all reasonable disbursements, advances and expenses incurred or made by it in addition to the compensation for its services. Such expenses will include the compensation, as agreed in writing by the Issuers and the Trustee, and
reasonable disbursements and expenses of the Trustee’s agents and counsel. 
 (b) The Issuers and the Guarantors will, jointly and
severally, indemnify and hold harmless the Trustee against any and all losses, claims, damages, expenses, fees, liabilities or expenses incurred by it arising out of or in connection with the acceptance or administration of its duties under this
Indenture, including the costs and expenses (including attorneys fees and expenses) of enforcing this Indenture against the Issuers and the Guarantors (including this Section 7.06) and defending itself against any claim (whether asserted by the
Issuers, the Guarantors, any Holder or any other Person) or liability in connection with the exercise or performance of any of its powers or duties hereunder, except to the extent any such loss, liability or expense may be attributable to its
negligence or bad faith. The Trustee will notify the Issuers promptly of any claim for which it may seek indemnity. Failure by the Trustee to so notify the Issuers will not relieve the Issuers or any of the Guarantors of their obligations
hereunder. The Issuers or such Guarantor will defend the claim and the Trustee will cooperate in the defense. The Trustee may have separate counsel and the Issuers will pay the reasonable fees and expenses of such counsel. Neither the
Issuers nor any Guarantor need pay for any settlement made without its consent, which consent will not be unreasonably withheld. 
 (c) The
obligations of the Issuers and the Guarantors under this Section 7.06 will survive the satisfaction and discharge of this Indenture. 
 (d)
To secure the Issuers’ and the Guarantors’ payment obligations in this Section 7.06, the Trustee will have a Lien prior to the Notes on all money or property held or collected by the Trustee, except that held in trust to pay principal of,
premium on, if any, or interest on, particular Notes. Such Lien will survive the satisfaction and discharge of this Indenture and the earlier resignation or removal of the Trustee. 

  
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 (e) When the Trustee incurs expenses or renders services after an Event of Default specified in
Section 6.01(8) hereof occurs, the expenses and the compensation for the services (including the fees and expenses of its agents and counsel) are intended to constitute expenses of administration under any Bankruptcy Law. 

(f) The Trustee shall have no liability or responsibility for any action or inaction on the part of any Paying Agent, Registrar,
authenticating agent, Custodian (aside from the Trustee acting in such capacities and subject to the terms hereof). 
 Section 7.07 Replacement of
Trustee. 
 (a) A resignation or removal of the Trustee and appointment of a successor Trustee will become effective only upon the
successor Trustee’s acceptance of appointment as provided in this Section 7.07. 
 (b) The Trustee may resign in writing at any time
and be discharged from the trust hereby created by so notifying the Company. The Holders of a majority in aggregate principal amount of the then outstanding Notes may remove the Trustee by so notifying the Trustee and the Issuers in writing. The
Issuers may remove the Trustee if: 
 (1) the Trustee fails to comply with Section 7.09 hereof; 

(2) the Trustee is adjudged a bankrupt or an insolvent or an order for relief is entered with respect to the Trustee under any
Bankruptcy Law; 
 (3) a custodian or public officer takes charge of the Trustee or its property; or 

(4) the Trustee becomes incapable of acting. 

(c) If the Trustee resigns or is removed or if a vacancy exists in the office of Trustee for any reason, the Issuers will promptly appoint a
successor Trustee. Within one year after the successor Trustee takes office, the Holders of a majority in aggregate principal amount of the then outstanding Notes may appoint a successor Trustee to replace the successor Trustee appointed by the
Issuer. 
 (d) If a successor Trustee does not take office within 60 days after the retiring Trustee resigns or is removed, the retiring
Trustee, the Issuers, or the Holders of at least 10% in aggregate principal amount of the then outstanding Notes may petition, at the expense of the Issuers, any court of competent jurisdiction for the appointment of a successor Trustee. 

(e) If the Trustee, after written request by any Holder who has been a Holder for at least six months, fails to comply with Section 7.09
hereof, such Holder may petition any court of competent jurisdiction for the removal of the Trustee and the appointment of a successor Trustee. 

(f) A successor Trustee will deliver a written acceptance of its appointment to the retiring Trustee and to the Issuer. Thereupon, the
resignation or removal of the retiring Trustee will become effective, and the successor Trustee will have all the rights, powers and duties of the Trustee under this Indenture. The successor Trustee will deliver a notice of its succession to
Holders. The retiring Trustee will promptly transfer all property held by it as Trustee to the successor Trustee; provided, all sums owing to the Trustee hereunder have been paid and subject to the Lien provided for in Section 7.06
hereof. Notwithstanding replacement of the Trustee pursuant to this Section 7.07, the Company’s obligations under Section 7.06 hereof will continue for the benefit of the retiring Trustee. The Trustee shall have no responsibility for
any action or inaction of any successor Trustee.

  
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 Section 7.08 Successor Trustee by Merger, etc. 

If the Trustee consolidates, merges or converts into, or transfers all or substantially all of its corporate trust business to, another
corporation, the successor corporation without any further act will be the successor Trustee. 
 Section 7.09 Eligibility; Disqualification. 

There will at all times be a Trustee hereunder that is a corporation organized and doing business under the laws of the United States of
America or of any state thereof that is authorized under such laws to exercise corporate trustee power, that is subject to supervision or examination by federal or state authorities and that has a combined capital and surplus of at least $50.0
million as set forth in its most recent published annual report of condition. 
 ARTICLE 8 

LEGAL DEFEASANCE AND COVENANT DEFEASANCE 
 Section
8.01 Option to Effect Legal Defeasance or Covenant Defeasance. 
 The Issuers may at any time elect to have either Section 8.02 or
8.03 hereof be applied to all outstanding Notes upon compliance with the conditions set forth below in this Article 8. 
 Section 8.02 Legal Defeasance
and Discharge. 
 Upon the Issuers’ exercise under Section 8.01 hereof of the option applicable to this Section 8.02, the Issuers
and each of the Guarantors will, subject to the satisfaction of the conditions set forth in Section 8.04 hereof, be deemed to have been discharged from their obligations with respect to the Indenture and all outstanding Notes (including the Note
Guarantees) on the date the conditions set forth below are satisfied (hereinafter, “Legal Defeasance”). For this purpose, Legal Defeasance means that the Issuers and the Guarantors will be deemed to have paid and discharged the
entire Indebtedness represented by the outstanding Notes (including the Note Guarantees), which will thereafter be deemed to be “outstanding” only for the purposes of Section 8.05 hereof and the other Sections of this Indenture referred to
in clauses (a) and (b) below, and to have satisfied all their other obligations under such Notes, the Note Guarantees and this Indenture (and the Trustee, on written demand of and at the expense of the Issuers, shall execute proper instruments
acknowledging the same), except for the following provisions which will survive until otherwise terminated or discharged hereunder: 
 (a)
the rights of Holders of outstanding Notes to receive payments in respect of the principal of, premium on, if any, or interest on, such Notes when such payments are due from the trust referred to in Section 8.04 hereof; 

(b) the Issuers’ obligations with respect to the Notes under Sections 2.06, 2.07, 2.10 and 4.02 hereof; 

(c) the rights, powers, trusts, duties and immunities of the Trustee hereunder and the Issuers’ and the Guarantors’ obligations in
connection therewith; and 
 (d) this Article 8. 

Subject to compliance with this Article 8, the Issuers may exercise its option under this Section 8.02 notwithstanding the prior exercise of
its option under Section 8.03 hereof. 

  
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 Section 8.03 Covenant Defeasance. 

Upon the Issuers’ exercise under Section 8.01 hereof of the option applicable to this Section 8.03, the Issuers and each of the
Guarantors will, subject to the satisfaction of the conditions set forth in Section 8.04 hereof, be released from each of their obligations under the covenants contained in Sections 3.09, 4.03, 4.07, 4.08, 4.09, 4.10, 4.11, 4.12, 4.14, 4.18 and 4.19
hereof and clauses (a)(3) and (a)(4) of Section 5.01 hereof with respect to the outstanding Notes on and after the date the conditions set forth in Section 8.04 hereof are satisfied (hereinafter, “Covenant Defeasance”), and the
Notes will thereafter be deemed not “outstanding” for the purposes of any direction, waiver, consent or declaration or act of Holders (and the consequences of any thereof) in connection with such covenants, but will continue to be deemed
“outstanding” for all other purposes hereunder (it being understood that such Notes will not be deemed outstanding for accounting purposes). For this purpose, Covenant Defeasance means that, with respect to the Indenture and outstanding
Notes and Note Guarantees, the Issuers and the Guarantors may omit to comply with and will have no liability in respect of any term, condition or limitation set forth in any such covenant, whether directly or indirectly, by reason of any reference
elsewhere herein to any such covenant or by reason of any reference in any such covenant to any other provision herein or in any other document and such omission to comply will not constitute a Default or an Event of Default under Section 6.01
hereof, but, except as specified above, the remainder of this Indenture and such Notes and Note Guarantees will be unaffected thereby. In addition, upon the Issuers’ exercise under Section 8.01 hereof of the option applicable to this Section
8.03, subject to the satisfaction of the conditions set forth in Section 8.04 hereof, Sections 6.01(3), (4), (5), (6), (7) (only as such clause 7 applies to Significant Subsidiaries) and (8) (only as such clause 8 applies to Significant
Subsidiaries) hereof will not constitute Events of Default. 
 Section 8.04 Conditions to Legal or Covenant Defeasance. 

In order to exercise either Legal Defeasance or Covenant Defeasance under either Section 8.02 or 8.03 hereof:

(a) the Issuers must irrevocably deposit with the Trustee, in trust, for the benefit of the Holders of the Notes, cash in U.S. dollars,
non-callable Government Securities, or a combination thereof, in amounts as will be sufficient, in the opinion of a nationally recognized investment bank, appraisal firm or firm of independent public accountants, to pay the principal of, premium on,
if any, and interest on, the outstanding Notes on the stated date for payment thereof or on the applicable redemption date, as the case may be, and the Issuers must specify whether such Notes are being defeased to such stated date for payment or to
a particular redemption date; 
 (b) in the case of an election of Legal Defeasance under Section 8.02 hereof, the Issuers must deliver to
the Trustee an Opinion of Counsel reasonably acceptable to the Trustee confirming that, subject to customary assumptions and exclusions:

(1) the Issuers have received from, or there has been published by, the Internal Revenue Service a ruling; or 

(2) since the Issue Date, there has been a change in the applicable U.S. federal income tax law, 

  
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 in either case to the effect that, and based thereon such Opinion of Counsel shall confirm that,
the Holders of the outstanding notes will not recognize income, gain or loss for U.S. federal income tax purposes as a result of such Legal Defeasance and will be subject to U.S. federal income tax on the same amounts, in the same manner and at the
same times as would have been the case if such Legal Defeasance had not occurred; 
 (c) in the case of an election of Covenant Defeasance
under Section 8.03 hereof, the Issuers must deliver to the Trustee an Opinion of Counsel reasonably acceptable to the Trustee confirming that, subject to customary assumptions and exclusions, the Holders of the outstanding notes will not recognize
income, gain or loss for U.S. federal income tax purposes as a result of such Covenant Defeasance and will be subject to U.S. federal income tax on the same amounts, in the same manner and at the same times as would have been the case if such
Covenant Defeasance had not occurred; 
 (d) no Default or Event of Default has occurred and is continuing on the date of such deposit
(other than a Default or Event of Default resulting from the borrowing of funds to be applied to such deposit (and any similar concurrent deposit relating to other Indebtedness), and the granting of Liens to secure such borrowings); 

(e) such Legal Defeasance or Covenant Defeasance will not result in a breach or violation of, or constitute a default under, any material
agreement or instrument (other than this Indenture and the agreements governing any other Indebtedness being defeased, discharged or replaced) to which the Issuers or any of the Guarantors is a party or by which the Issuers or any of the Guarantors
is bound; 
 (f) the Issuers must deliver to the Trustee an Officer’s Certificate stating that the deposit was not made by the Issuers
with the intent of preferring the Holders of notes over the other creditors of the Issuers with the intent of defeating, hindering, delaying or defrauding any creditors of the Issuers or others; and 

(g) the Issuers must deliver to the Trustee an Officer’s Certificate and an Opinion of Counsel (which Opinion of Counsel may be subject
to customary assumptions and exclusions), each stating that all conditions precedent relating to the Legal Defeasance or the Covenant Defeasance have been complied with.

Notwithstanding the foregoing provisions of this Section 8.04, the conditions set forth in the foregoing subsections (b), (c), (d), (e), (f)
and (g) of this Section 8.04 need not be satisfied so long as, at the time the Issuers make the deposit described in subsection (a), (i) no Default under Section 6.01(1), (2), (7) and (8) has occurred and is continuing on the date of such deposit
and after giving effect thereto and (ii) all Notes not previously delivered to the Trustee for cancellation (x) have become due and payable, (y) will become due and payable at their Stated Maturity within one year or (z) are to be
called for redemption within one year under arrangements satisfactory to the Trustee for the giving of notice of redemption by the Trustee in the name, and at the expense, of the Issuer. If the conditions in the preceding sentence are
satisfied, the Issuers shall be deemed to have exercised their Covenant Defeasance option.
 Section 8.05 Deposited Money and Government Securities to be
Held in Trust; Other Miscellaneous Provisions. 
 Subject to Section 8.06 hereof, all money and non-callable Government Securities
(including the proceeds thereof) deposited with the Trustee (or other qualifying trustee, collectively for purposes of this Section 8.05, the “Trustee”) pursuant to Section 8.04 hereof in respect of the outstanding Notes will be
held in trust and applied by the Trustee, in accordance with the provisions of such Notes and this 

  
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Indenture, to the payment, either directly or through any Paying Agent (including the Issuers acting as Paying Agent) as the Trustee may determine, to the Holders of such Notes of all sums due
and to become due thereon in respect of principal, premium, if any, interest, but such money need not be segregated from other funds except to the extent required by law. 

The Issuers will pay and indemnify the Trustee against any tax, fee or other charge imposed on or assessed against the cash or non-callable
Government Securities deposited pursuant to Section 8.04 hereof or the principal and interest received in respect thereof other than any such tax, fee or other charge which by law is for the account of the Holders of the outstanding Notes. 

Notwithstanding anything in this Article 8 to the contrary, the Trustee will deliver or pay to the Company from time to time upon the written
request of the Issuers any money or non-callable Government Securities held by it as provided in Section 8.04 hereof which, in the opinion of a nationally recognized firm of independent public accountants expressed in a written certification thereof
delivered to the Trustee (which may be the opinion delivered under Section 8.04(a) hereof), are in excess of the amount thereof that would then be required to be deposited to effect an equivalent Legal Defeasance or Covenant Defeasance. 

Section 8.06 Repayment to Issuers. 
 Any
money deposited with the Trustee or any Paying Agent, or then held by the Issuers, in trust for the payment of the principal of, premium on, if any, or interest on, any Note and remaining unclaimed for two years after such principal, premium, if
any, or interest has become due and payable shall be paid to the Issuers on its written request or (if then held by the Issuer) will be discharged from such trust; and the Holder of such Note will thereafter be permitted to look only to the Issuers
for payment thereof, and all liability of the Trustee or such Paying Agent with respect to such trust money, and all liability of the Issuers as trustee thereof, will thereupon cease.

Section 8.07 Reinstatement. 
 If the
Trustee or Paying Agent is unable to apply any U.S. dollars or non-callable Government Securities in accordance with Section 8.02 or 8.03 hereof, as the case may be, by reason of any order or judgment of any court or governmental authority
enjoining, restraining or otherwise prohibiting such application, then the Issuers’ and the Guarantors’ obligations under this Indenture and the Notes and the Note Guarantees will be revived and reinstated as though no deposit had occurred
pursuant to Section 8.02 or 8.03 hereof until such time as the Trustee or Paying Agent is permitted to apply all such money in accordance with Section 8.02 or 8.03 hereof, as the case may be; provided, however, that, if the Issuers makes any
payment of principal of, premium on, if any, or interest on, any Note following the reinstatement of its obligations, the Company will be subrogated to the rights of the Holders of such Notes to receive such payment from the money held by the
Trustee or Paying Agent. 
 ARTICLE 9 

AMENDMENT, SUPPLEMENT AND WAIVER 
 Section 9.01
Without Consent of Holders of Notes. 
 Notwithstanding Section 9.02, without the consent of any Holder of Notes, the Issuers, the
Guarantors and the Trustee may amend or supplement this Indenture, the Notes or the Note Guarantees: 
 (a) to cure any ambiguity, defect or
inconsistency; 

  
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 (b) to provide for uncertificated Notes in addition to or in place of certificated Notes
(provided that the uncertificated notes are issued in registered form for purposes of Section 163(f) of the Code); 
 (c) to
provide for the assumption of the Issuers’ or a Guarantor’s obligations to Holders of notes and Note Guarantees in the case of a merger or consolidation or sale of all or substantially all of the Issuers’ or such Guarantor’s
assets, as applicable; 
 (d) to make any change that would provide any additional rights or benefits to the Holders of the Notes or that
does not adversely affect the legal rights under this Indenture of any Holder; 
 (e) to comply with requirements of the SEC in order to
effect or maintain the qualification of this Indenture under the Trust Indenture Act of 1939, as amended; 
 (f) to conform the text of this
Indenture, the Notes or the Note Guarantees to any provision of the “Description of the Notes” section of the Offering Memorandum, to the extent that the Trustee has received an Officer’s Certificate to the effect that such text
constitutes an unintended conflict with the description of the corresponding provision in that “Description of the Notes;” 
 (g)
to provide for the issuance of Additional Notes in accordance with the limitations set forth in this Indenture as of the Issue Date; 
 (h)
to evidence and provide for the acceptance of appointment under this Indenture by a successor Trustee; 
 (i) to release any Guarantor in
accordance with the terms of this Indenture; 
 (j) to allow any Guarantor to execute a supplemental indenture and/or a Note Guarantee with
respect to the Notes; 
 (k) to add additional co-issuers (to the extent such entities are organized under the laws of the United States,
any state of the United States or the District of Columbia, Luxembourg, Bermuda or Ireland) with respect to the Notes in accordance with the limitations set forth in this Indenture; or 

(l) make any amendment to the provisions of Section 2.06 relating to the transfer and legending of Notes as permitted by this Indenture,
including to facilitate the issuance and administration of Notes; provided, however, that such amendment does not adversely affect the rights of Holders to transfer Notes in any material respect. 

Upon the request of the Issuers, and upon receipt by the Trustee of the documents described in Section 7.02 hereof, the Trustee will join with
the Issuers and the Guarantors in the execution of any amended or supplemental indenture authorized or permitted by the terms of this Indenture and to make any further appropriate agreements and stipulations that may be therein contained, but the
Trustee will not be obligated to enter into such amended or supplemental indenture that affects its own rights, duties or immunities under this Indenture or otherwise. 

Section 9.02 With Consent of Holders of Notes. 

Except as provided below in this Section 9.02, each of this Indenture, the Notes or the Note Guarantees may be amended or supplemented with
the consent of the Holders of at least a majority in aggregate principal amount of the then outstanding Notes (including, without limitation, additional notes, 

  
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if any) voting as a single class (including, without limitation, consents obtained in connection with a tender offer or exchange offer for, or purchase of, the Notes), and any existing Default or
Event of Default (other than a Default or Event of Default in the payment of the principal of, premium on, if any, or interest on, the Notes, except a payment default resulting from an acceleration that has been rescinded) or compliance with any
provision of this Indenture or the Notes or the Note Guarantees may be waived with the consent of the Holders of a majority in aggregate principal amount of the then outstanding Notes (including, without limitation, Additional Notes, if any) voting
as a single class (including, without limitation, consents obtained in connection with a purchase of, or tender offer or exchange offer for, the Notes). 

Upon the request of the Issuers, and upon the filing with the Trustee of evidence satisfactory to the Trustee of the consent of the Holders of
Notes as aforesaid, and upon receipt by the Trustee of the documents described in Section 7.02 hereof, the Trustee will join with the Issuers and the Guarantors in the execution of such amended or supplemental indenture unless such amended or
supplemental indenture directly affects the Trustee’s own rights, duties or immunities under this Indenture or otherwise, in which case the Trustee may in its discretion, but will not be obligated to, enter into such amended or supplemental
indenture. 
 It is not necessary for the consent of the Holders of Notes under this Section 9.02 to approve the particular form of any
proposed amendment, supplement or waiver, but it is sufficient if such consent approves the substance thereof. 
 After an amendment,
supplement or waiver under this Section 9.02 becomes effective, the Issuers will promptly deliver to the Holders of Notes affected thereby a notice briefly describing the amendment, supplement or waiver. Any failure of the Issuers to deliver
such notice, or any defect therein, will not, however, in any way impair or affect the validity of any such amended or supplemental indenture or waiver. Subject to Sections 6.04 and 6.07 hereof, the Holders of a majority in aggregate principal
amount of the Notes then outstanding voting as a single class may waive compliance in a particular instance by the Issuers or any Guarantor with any provision of this Indenture, the Notes or the Note Guarantees. However, without the consent of
each Holder affected, an amendment, supplement or waiver under this Section 9.02 may not (with respect to any Notes held by a non-consenting Holder): 

(a) reduce the principal amount of Notes whose Holders must consent to an amendment, supplement or waiver; 

(b) reduce the principal of or change the fixed maturity of any note or alter or waive any of the provisions with respect to the payment of
Additional Amounts or the redemption of the Notes (except those provisions relating to Sections 4.10 and 4.14 hereof); 
 (c) reduce the
rate of or change the time for payment of interest, including default interest, on any Note; 
 (d) waive a Default or Event of Default in
the payment of principal of, premium on, if any, or interest on, the Notes (except a rescission of acceleration of the Notes by the Holders of at least a majority in aggregate principal amount of the then outstanding Notes and a waiver of the
payment default that resulted from such acceleration); 
 (e) make any Note payable in money other than that stated in the Notes; 

  
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 (f) make any change in the provisions of this Indenture relating to waivers of past Defaults or
the rights of Holders of Notes to receive payments of principal of, premium on, if any, or interest on, the Notes; 
 (g) waive a redemption
payment with respect to any Note (other than a payment required by Sections 4.10 or 4.14 hereof); 
 (h) release any Guarantor from any of
its obligations under its Note Guarantee or this Indenture, except in accordance with the terms of this Indenture; or 
 (i) make any change
in the preceding amendment and waiver provisions. 
 Section 9.03 Revocation and Effect of Consents. 

Until an amendment, supplement or waiver becomes effective, a consent to it by a Holder of a Note is a continuing consent by the Holder of a
Note and every subsequent Holder of a Note or portion of a Note that evidences the same debt as the consenting Holder’s Note, even if notation of the consent is not made on any Note. However, any such Holder of a Note or subsequent Holder
of a Note may revoke the consent as to its Note if the Trustee receives written notice of revocation before the date the amendment, supplement or waiver becomes effective. An amendment, supplement or waiver becomes effective in accordance with
its terms and thereafter binds every Holder. 
 Section 9.04 Notation on or Exchange of Notes. 

The Trustee may place an appropriate notation about an amendment, supplement or waiver on any Note thereafter authenticated. The Issuers
in exchange for all Notes may issue and the Trustee shall, upon receipt of an Authentication Order, authenticate new Notes that reflect the amendment, supplement or waiver. 

Failure to make the appropriate notation or issue a new Note will not affect the validity and effect of such amendment, supplement or waiver.

 Section 9.05 Trustee to Sign Amendments, etc. 

The Trustee will sign any amended or supplemental indenture authorized pursuant to this Article 9 if the amendment or supplement does not
adversely affect the rights, duties, liabilities or immunities of the Trustee. The Issuers may not sign an amended or supplemental indenture until the Board of Directors of the Issuers approves it. In executing any amended or supplemental
indenture, the Trustee will receive and (subject to Section 7.01 hereof) will be fully protected in conclusively relying upon, in addition to the documents required by Section 12.03 hereof, an Officer’s Certificate and an Opinion of Counsel
stating that the execution of such amended or supplemental indenture is authorized or permitted by this Indenture and that such supplemental indenture constitutes the valid and binding obligation of the Issuers and any Guarantors party thereto,
enforceable against such parties in accordance with its terms, subject to customary exceptions. 

  
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 ARTICLE 10 

NOTE GUARANTEES 
 Section 10.01 Guarantee.

 (a) Subject to this Article 10, each of the Guarantors hereby jointly and severally, unconditionally guarantees to each Holder of a Note
authenticated and delivered by the Trustee and to the Trustee and its successors and assigns, irrespective of the validity and enforceability of this Indenture, the Notes or the obligations of the Issuers hereunder or thereunder, that: 

(1) the principal of, premium on, if any, and interest on, the Notes will be promptly paid in full when due, whether at
maturity, by acceleration, redemption or otherwise, and interest on the overdue principal of, premium on, if any, and interest on, the Notes, if lawful, and all other obligations of the Issuers to the Holders or the Trustee hereunder or thereunder
will be promptly paid in full or performed, all in accordance with the terms hereof and thereof; and 
 (2) in case of any
extension of time of payment or renewal of any Notes or any of such other obligations, that same will be promptly paid in full when due or performed in accordance with the terms of the extension or renewal, whether at stated maturity, by
acceleration or otherwise. 
 Failing payment when due of any amount so guaranteed or any performance so guaranteed for whatever reason, the
Guarantors will be jointly and severally obligated to pay the same immediately. Each Guarantor agrees that this is a guarantee of payment and not a guarantee of collection. 

(b) The Guarantors hereby agree that their obligations hereunder are unconditional, irrespective of the validity, regularity or enforceability
of the Notes or this Indenture, the absence of any action to enforce the same, any waiver or consent by any Holder of the Notes with respect to any provisions hereof or thereof, the recovery of any judgment against the Issuers, any action to enforce
the same or any other circumstance which might otherwise constitute a legal or equitable discharge or defense of a guarantor. Each Guarantor hereby waives diligence, presentment, demand of payment, filing of claims with a court in the event of
insolvency or bankruptcy of the Issuers, any right to require a proceeding first against the Issuers, protest, notice and all demands whatsoever and covenant that this Note Guarantee will not be discharged except by complete performance of the
obligations contained in the Notes and this Indenture. 
 (c) If any Holder or the Trustee is required by any court or otherwise to return
to the Company, the Guarantors or any custodian, trustee, liquidator or other similar official acting in relation to either the Issuers or the Guarantors, any amount paid by either to the Trustee or such Holder, this Note Guarantee, to the extent
theretofore discharged, will be reinstated in full force and effect. 
 (d) Each Guarantor agrees that it will not be entitled to any right
of subrogation in relation to the Holders in respect of any obligations guaranteed hereby until payment in full of all obligations guaranteed hereby. Each Guarantor further agrees that, as between the Guarantors, on the one hand, and the
Holders and the Trustee, on the other hand, (1) the maturity of the obligations guaranteed hereby may be accelerated as provided in Article 6 hereof for the purposes of this Note Guarantee, notwithstanding any stay, injunction or other prohibition
preventing such acceleration in respect of the obligations guaranteed hereby, and (2) in the event of any declaration of acceleration of such obligations as provided in Article 6 hereof, such obligations (whether or not due and payable) will
forthwith become due and payable by the Guarantors for the purpose of this Note Guarantee. The Guarantors will have the right to seek contribution from any non-paying Guarantor so long as the exercise of such right does not impair the rights of
the Holders under the Note Guarantee. 

  
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 Section 10.02 Limitation on Guarantor Liability. 

Each Guarantor and by its acceptance of Notes, each Holder, hereby confirms that it is the intention of all such parties that the Note
Guarantee of such Guarantor not constitute a fraudulent transfer or conveyance for purposes of Bankruptcy Law, the Uniform Fraudulent Conveyance Act, the Uniform Fraudulent Transfer Act or any similar federal state law or similar foreign law to the
extent applicable to any Note Guarantee or unlawful financial assistance within the meaning of Section 82 of the Irish Companies Act 2014 (as amended). To effectuate the foregoing intention, the Trustee, the Holders and the Guarantors hereby
irrevocably agree that the obligations of such Guarantor will be limited to the maximum amount that will, after giving effect to such maximum amount and all other contingent and fixed liabilities of such Guarantor that are relevant under such laws,
and after giving effect to any collections from, rights to receive contribution from or payments made by or on behalf of any other Guarantor in respect of the obligations of such other Guarantor under this Article 10, result in the obligations of
such Guarantor under its Note Guarantee not constituting a fraudulent transfer or conveyance under federal, state or similar foreign law or unlawful financial assistance within the meaning of Section 82 of the Irish Companies Act 2014 (as amended).

 Section 10.03 Issuance and Delivery of Note Guarantee. 

To evidence its Note Guarantee set forth in Section 10.01, each Guarantor hereby agrees that this Indenture (or, a supplemental indenture to
this Indenture) shall be executed on behalf of such Guarantor by an Officer of such Guarantor.
 Each Guarantor hereby agrees that its Note
Guarantee set forth in Section 10.01 shall remain in full force and effect notwithstanding the absence of the endorsement of any notation of such Note Guarantee on the Notes. 

If an Officer whose signature is on this Indenture or on the Note Guarantee no longer holds that office at the time the Trustee authenticates
the Note on which a Note Guarantee is endorsed, the Note Guarantee will be valid nevertheless. 
 The delivery of any Note by the Trustee,
after the authentication thereof hereunder, will constitute due delivery of the Note Guarantee set forth in this Indenture on behalf of the Guarantors. Upon execution of a supplemental indenture to this Indenture by any Guarantor in the form of
Exhibit E hereto, the Note Guarantee set forth in this Indenture and such supplemental indenture shall be deemed duly delivered, without any further action by any Person, on behalf of such Guarantor. All the Note Guarantees so issued will in
all respects have the same legal rank and benefit under this Indenture as the Note Guarantees theretofore and thereafter issued in accordance with the terms of this Indenture as though all of such Note Guarantees had been issued at the date of the
execution hereof. 
 Section 10.04 Guarantors May Consolidate, etc., on Certain Terms. 

Except as otherwise provided in Section 10.05 hereof, no Guarantor (other than the Parent, which is governed by Section 5.01) may sell or
otherwise dispose of all or substantially all of its assets to, or consolidate with or merge with or into (whether or not such Guarantor is the surviving Person) another Person, other than the Parent, the Issuers or another Guarantor, unless
either:
 (a) subject to Section 10.05 hereof, the Person acquiring the property in any such sale or disposition or the Person formed by or
surviving any such consolidation or merger (the “Successor Guarantor”) unconditionally assumes all the obligations of that Guarantor under its Note Guarantees and this Indenture on the terms set forth herein or therein, pursuant to a
supplemental indenture in form and substance reasonably satisfactory to the Trustee; or 
 (b) the Note Guarantee of such Guarantor shall be
released in accordance with Section 10.05 upon, or in connection with, such sale, disposition, consolidation or merger. 

  
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 In case of any such consolidation, merger, sale or disposition and upon the assumption by the
Successor Guarantor, by a supplemental indenture, of the Note Guarantees and the due and punctual performance of all of the covenants and conditions of this Indenture to be performed by the Guarantor, such Successor Guarantor will succeed to and be
substituted for the Guarantor with the same effect as if it had been named herein as a Guarantor.
 Except as set forth in Articles 4 and 5
hereof, and notwithstanding clauses (a) and (b) above, nothing contained in this Indenture or in any of the Notes will prevent any consolidation or merger of a Guarantor with or into the Parent, the Issuers or another Guarantor, or will prevent any
sale or conveyance of the property of a Guarantor as an entirety or substantially as an entirety to the Parent or another Guarantor. 
 This
Section 10.04 will not apply to the Merger. Notwithstanding anything to the contrary above, in the event the Acquisition does not occur, the Merger shall immediately be consummated without regard to any of the provisions described above. 

Section 10.05 Releases. 
 Any Guarantor
will be automatically and unconditionally released from all obligations under its Note Guarantee, and such Note Guarantee shall thereupon terminate and be discharged and of no further force and effect:

(a) concurrently with any sale, exchange, disposition or transfer (by merger or otherwise) of any Capital Stock, or all or substantially all
assets, of such Guarantor in accordance with the applicable provisions of this Indenture following which such Guarantor is no longer a Restricted Subsidiary of the Parent; 

(b) if the Parent designates any Restricted Subsidiary that is a Guarantor to be an Unrestricted Subsidiary in accordance with the applicable
provisions of this Indenture; 
 (c) upon Legal Defeasance, Covenant Defeasance or satisfaction and discharge of this Indenture as provided
in Articles 8 and 11 hereof; 
 (d) to the extent that such Guarantor is not an Immaterial Subsidiary solely due to the operation of clause
(i) of the definition of “Immaterial Subsidiary,” upon the release of the guarantee referred to in such clause; or 
 (e) in
the case of a Note Guarantee made by a Guarantor as a result of its Guarantee of Triggering Indebtedness pursuant to Section 4.18, the release of such Guarantor from the relevant Indebtedness (except in the case of Indebtedness under the Credit
Agreement, a release resulting from the repayment in full of such Indebtedness). 
 Any Guarantor not released from its obligations under
its Note Guarantee as provided in this Section 10.05 will remain liable for the full amount of principal of, premium on, if any, and interest on, the Notes and for the other obligations of any Guarantor under this Indenture as provided in this
Article 10. 

  
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 ARTICLE 11 

SATISFACTION AND DISCHARGE 
 Section 11.01
Satisfaction and Discharge. 
 This Indenture will be discharged and will cease to be of further effect as to all Notes issued
hereunder, when: 
 (a) either: 

(1) all Notes that have been authenticated, except lost, stolen or destroyed Notes that have been replaced or paid and Notes
for whose payment money has been deposited in trust and thereafter repaid to the Issuers, have been delivered to the Trustee for cancellation; or 

(2) all outstanding Notes not previously delivered to the Trustee for cancellation (i) have become due and payable,
(ii) will become due and payable at their Stated Maturity within one year or (iii) are to be called for redemption within one year under arrangements satisfactory to the Trustee for the giving of notice of redemption by the Trustee in the
name, and at the expense, of the Issuers and the Issuers or any Guarantor has irrevocably deposited or caused to be deposited with the Trustee as trust funds in trust solely for the benefit of the Holders, cash in U.S. dollars, non-callable
Government Securities, or a combination thereof, in amounts as will be sufficient, without consideration of any reinvestment of interest, to pay and discharge the entire Indebtedness on the Notes not delivered to the Trustee for cancellation for
principal of, premium on, if any, and interest on, the Notes to the date of maturity or redemption; 
 (b) the Issuers or any Guarantor has
or have paid or caused to be paid all sums payable by it or them under this Indenture; and 
 (c) in the case of clause (a)(2) of this
Section 11.01, the Issuers have delivered irrevocable instructions to the Trustee under this Indenture to apply the deposited money toward the payment of the Notes at maturity or on the redemption date, as the case may be. 

In addition, the Issuers must deliver an Officer’s Certificate and an Opinion of Counsel to the Trustee stating that all conditions precedent to
satisfaction and discharge have been satisfied. 
 Notwithstanding the satisfaction and discharge of this Indenture, if money has been
deposited with the Trustee pursuant to Section 11.01(a)(2), the provisions of Sections 11.02 and 8.06 hereof will survive. In addition, nothing in this Section 11.01 will be deemed to discharge those provisions of Section 7.06 hereof, that, by
their terms, survive the satisfaction and discharge of this Indenture and the earlier resignation or removal of the Trustee. 
 Section 11.02 Application
of Trust Money. 
 Subject to the provisions of Section 8.06 hereof, all money deposited with the Trustee pursuant to Section 11.01
hereof shall be held in trust and applied by it, in accordance with the provisions of the Notes and this Indenture, to the payment, either directly or through any Paying Agent (including the 

  
 101 








 
Company acting as its own Paying Agent) as the Trustee may determine, to the Persons entitled thereto, of the principal, premium, if any, and interest for whose payment such money has been
deposited with the Trustee; but such money need not be segregated from other funds except to the extent required by law. 
 If the Trustee
or Paying Agent is unable to apply any money or Government Securities in accordance with Section 11.01 hereof by reason of any legal proceeding or by reason of any order or judgment of any court or governmental authority enjoining, restraining or
otherwise prohibiting such application, the Company’s and any Guarantor’s obligations under this Indenture and the Notes shall be revived and reinstated as though no deposit had occurred pursuant to Section 11.01 hereof; provided,
that if the Company has made any payment of principal of, premium on, if any, or interest on, any Notes because of the reinstatement of its obligations, the Issuers shall be subrogated to the rights of the Holders of such Notes to receive such
payment from the money or Government Securities held by the Trustee or Paying Agent. 
 ARTICLE 12 

MISCELLANEOUS 
 Section 12.01 Notices. 

Any notice or communication by the Parent, the Issuers, any Guarantor or the Trustee to the others is duly given if in writing and delivered
in Person or by first class mail (registered or certified, return receipt requested), facsimile transmission or overnight air courier guaranteeing next day delivery, to the others’ address: 

If to the Parent, Issuers and/or any Guarantor: 

Horizon Pharma, Inc. 
 Horizon
Pharma USA, Inc. 
 c/o Horizon Pharma Public Limited Company 

Connaught House, 1st Floor 
 1
Burlington Road 
 Dublin 4, Ireland 

Attention: Paul W. Hoelscher, Chief Financial Officer 

If to the Trustee: 
 U.S. Bank
National Association 
 Corporate Trust Services 

West Side Flats 
 60 Livingston
Avenue 
 St. Paul MN 55107-1419 

Fax: (651) 466-7430 

Attention: Raymond S. Haverstock 

With a copy to: 
 Dorsey &
Whitney LLP 
 51 West 52nd Street 

New York, NY 10019-6119 

Attention: Mark Jutsen 

  
 102 








 The Parent, the Issuers, any Guarantor or the Trustee, by notice to the others, may designate
additional or different addresses for subsequent notices or communications. 
 All notices and communications (other than those sent to
Holders) will be deemed to have been duly given: at the time delivered by hand, if personally delivered; five Business Days after being deposited in the mail, postage prepaid, if mailed; when receipt acknowledged, if transmitted by facsimile; and
the next Business Day after timely delivery to the courier, if sent by overnight air courier guaranteeing next day delivery. 
 Any notice
or communication to a Holder will be mailed by first class mail, certified or registered, return receipt requested, or by overnight air courier guaranteeing next day delivery to its address shown on the register kept by the Registrar;
provided that notices given to Holders of Global Notes may be given through the facilities of the Depositary. Failure to deliver a notice or communication to a Holder or any defect in it will not affect its sufficiency with respect to
other Holders. 
 If a notice or communication is delivered in the manner provided above within the time prescribed, it is duly given,
whether or not the addressee receives it. 
 If the Parent or the Issuers mail a notice or communication to Holders, it will mail a copy to
the Trustee and each Agent at the same time. 
 Section 12.02 Communication by Holders of Notes with Other Holders of Notes. 

Holders may communicate with other Holders with respect to their rights under this Indenture or the Notes. 

Section 12.03 Certificate and Opinion as to Conditions Precedent. 

Upon any request or application by the Parent and/or the Issuers to the Trustee to take any action under this Indenture, the Parent and/or the
Issuers, as applicable, shall furnish to the Trustee: 
 (a) an Officer’s Certificate in form and substance reasonably satisfactory to
the Trustee (which must include the statements set forth in Section 12.04 hereof) stating that, in the opinion of the signers, all conditions precedent, if any, provided for in this Indenture relating to the proposed action have been complied
with; and 
 (b) an Opinion of Counsel in form and substance reasonably satisfactory to the Trustee (which must include the statements set
forth in Section 12.04 hereof) stating that, in the opinion of such counsel, all such conditions precedent have been complied with. 
 Section 12.04
Statements Required in Certificate or Opinion. 
 Each certificate or opinion with respect to compliance with a condition or covenant
provided for in this Indenture and must include: 
 (a) a statement that the Person making such certificate or opinion has read such
covenant or condition; 
 (b) a brief statement as to the nature and scope of the examination or investigation upon which the statements or
opinions contained in such certificate or opinion are based; 

  
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 (c) a statement that, in the opinion of such Person, he or she has made such examination or
investigation as is necessary to enable him or her to express an informed opinion as to whether or not such covenant or condition has been satisfied; and 

(d) a statement as to whether or not, in the opinion of such Person, such condition or covenant has been satisfied. 

Section 12.05 Form of Documents Delivered to Trustee. 

In any case where several matters are required to be certified by, or covered by an opinion of, any specified Person, it is not necessary that
all such matters be certified by, or covered by the opinion of, only one such Person, or that they be so certified or covered by only one document, but one such Person may certify or give an opinion with respect to some matters and one or more other
such Persons as to other matters, and any such Person may certify or give an opinion as to such matters in one or several documents. 
 Any
certificate or opinion of an officer of the Issuers or Parent may be based, insofar as it relates to legal matters, upon a certificate or opinion of, or representations by, counsel, unless such officer knows, or in the exercise of reasonable care
should know, that the certificate or opinion or representations with respect to the matters upon which his/her certificate or opinion is based are erroneous. Any such certificate or Opinion of Counsel may be based, insofar as it relates to
factual matters, upon a certificate or opinion of, or representations by, an officer or officers of the Issuers or Parent stating that the information with respect to such factual matters is in the possession of the Issuers or Parent, unless such
counsel knows, or in the exercise of reasonable care should know, that the certificate or opinion or representations with respect to such matters are erroneous.

Where any Person is required to make, give or execute two or more applications, requests, consents, certificates, statements, opinions or
other instruments under this Indenture, they may, but need not, be consolidated and form one instrument. 
 Section 12.06 Rules by Trustee and
Agents. 
 The Trustee may make reasonable rules for action by or at a meeting of Holders. The Registrar or Paying Agent may make
reasonable rules and set reasonable requirements for its functions. 
 Section 12.07 No Personal Liability of Directors, Officers, Employees and
Stockholders. 
 No director, officer, employee, incorporator or stockholder of the Issuers or any Guarantor, as such, will have any
liability for any obligations of the Issuers or the Guarantors under the Notes, this Indenture, the Note Guarantees or for any claim based on, in respect of, or by reason of, such obligations or their creation. Each Holder of Notes by accepting
a Note waives and releases all such liability. The waiver and release are part of the consideration for issuance of the Notes. The waiver may not be effective to waive liabilities under the federal securities laws. 

Section 12.08 Governing Law; Waiver of Jury Trial. 

THIS INDENTURE AND THE NOTES, INCLUDING ANY NOTE GUARANTEES AND THE RIGHTS AND DUTIES OF THE PARTIES THEREUNDER SHALL BE GOVERNED BY AND
CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. THE ISSUERS AND THE TRUSTEE HEREBY IRREVOCABLY WAIVE, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF
OR RELATING TO THIS INDENTURE, THE NOTES OR THE TRANSACTIONS CONTEMPLATED HEREBY. 

  
 104 








 Section 12.09 No Adverse Interpretation of Other Agreements. 

This Indenture may not be used to interpret any other indenture, loan or debt agreement of the Parent or its Subsidiaries or of any other
Person. Any such indenture, loan or debt agreement may not be used to interpret this Indenture. 
 Section 12.10 Successors. 

All agreements of the Parent, the Issuers and the other Guarantors in this Indenture and the Notes will bind its successors. All
agreements of the Trustee in this Indenture will bind its successors. All agreements of each Guarantor in this Indenture will bind its successors, except as otherwise provided in Section 10.05 hereof. 

Section 12.11 Severability. 
 In case any
provision in this Indenture or in the Notes is invalid, illegal or unenforceable, the validity, legality and enforceability of the remaining provisions will not in any way be affected or impaired thereby. 

Section 12.12 Counterpart Originals. 

The parties may sign any number of copies of this Indenture. Each signed copy (which may be provided via facsimile or other electronic
transmission) will be an original, but all of them together represent the same agreement.
 Section 12.13 Table of Contents, Headings, etc. 

The Table of Contents, Cross-Reference Table and Headings of the Articles and Sections of this Indenture have been inserted for convenience of
reference only, are not to be considered a part of this Indenture and will in no way modify or restrict any of the terms or provisions hereof. 
 Section
12.14 U.S.A. Patriot Act 
 In no event shall the Trustee be responsible or liable for any failure or delay in the performance of its
obligations hereunder arising out of or caused by, directly or indirectly, forces beyond its control, including, without limitation, strikes, work stoppages, accidents, acts of war or terrorism, civil or military disturbances, nuclear or natural
catastrophes or disasters, and interruptions, loss or malfunctions of utilities, communications or computer (software and hardware) services; it being understood that the Trustee shall use reasonable efforts which are consistent with accepted
practices in the banking industry to resume performance as soon as practicable under the circumstances. 
 Section 12.15 Force Majeure 

In no event shall the Trustee be responsible or liable for any failure or delay in the performance of its obligations hereunder arising out of
or caused by, directly or indirectly, forces beyond its control, including, without limitation, strikes, work stoppages, accidents, acts of war or terrorism, civil or military disturbances, nuclear or natural catastrophes or acts of God, and
interruptions, loss or malfunctions of utilities, communications or computer (software and hardware) services; it being understood that the Trustee shall use reasonable efforts which are consistent with accepted practices in the banking industry to
resume performance as soon as practicable under the circumstances. 

  
 105 








 [Signatures on following page] 

  
 106 








 SIGNATURES 

Dated as of October 25, 2016 
  

					
	HORIZON PHARMA, INC.
		
	By:	 	 /s/ Paul W. Hoelscher

		 	Name:	 	Paul W. Hoelscher
		 	Title:	 	EVP and Chief Financial Officer
	
	HORIZON PHARMA USA, INC.
		
	By:	 	 /s/ Paul W. Hoelscher

		 	Name:	 	Paul W. Hoelscher
		 	Title:	 	EVP and Chief Financial Officer



  
 Horizon –
October 2016 Bond Offering - Indenture 








 
					
	HORIZON PHARMA RHEUMATOLOGY LLC
	HZNP USA, LLC
	HORIZON THERAPEUTICS, LLC
		
	By:	 	 /s/ Paul W. Hoelscher

		 	Name:	 	Paul W. Hoelscher
		 	Title:	 	EVP and Chief Financial Officer



  
 Horizon –
October 2016 Bond Offering - Indenture 








 
					
	HORIZON PHARMA PUBLIC LIMITED COMPANY
		
	By:	 	 /s/ Paul W. Hoelscher

		 	Name:	 	Paul W. Hoelscher
		 	Title:	 	EVP and Chief Financial Officer
	
	HORIZON PHARMA AON LIMITED
		
	By:	 	 /s/ Zoë K. Hanson

		 	Name:	 	Zoë K. Hanson
		 	Title:	 	Director
	
	HORIZON PHARMA CAPITAL LIMITED
		
	By:	 	 /s/ David G. Kelly

		 	Name:	 	David G. Kelly
		 	Title:	 	Director
	
	HORIZON PHARMA DÓ LIMITED
		
	By:	 	 /s/ Zoë K. Hanson

		 	Name:	 	Zoë K. Hanson
		 	Title:	 	Director
	
	HORIZON PHARMA FINANCE LIMITED
		
	By:	 	 /s/ David G. Kelly

		 	Name:	 	David G. Kelly
		 	Title:	 	Director
	
	HORIZON PHARMA HOLDINGS LIMITED
		
	By:	 	 /s/ David G. Kelly

		 	Name:	 	David G. Kelly
		 	Title:	 	Director
	
	HORIZON PHARMA HOLDINGS 2 LIMITED
		
	By:	 	 /s/ David G. Kelly

		 	Name:	 	David G. Kelly
		 	Title:	 	Director



  
 Horizon –
October 2016 Bond Offering - Indenture 








 
					
	HORIZON PHARMA IRELAND LIMITED
		
	By:	 	 /s/ David G. Kelly

		 	Name:	 	David G. Kelly
		 	Title:	 	Director
	
	HORIZON PHARMA SERVICES LIMITED
		
	By:	 	 /s/ David G. Kelly

		 	Name:	 	David G. Kelly
		 	Title:	 	Director
	
	HORIZON PHARMA TREASURY DESIGNATED ACTIVITY COMPANY
		
	By:	 	 /s/ David G. Kelly

		 	Name:	 	David G. Kelly
		 	Title:	 	Director
	
	HORIZON PHARMA TRÍ LIMITED
		
	By:	 	 /s/ Zoë K. Hanson

		 	Name:	 	Zoë K. Hanson
		 	Title:	 	Director
	
	HZNP LIMITED
		
	By:	 	 /s/ Zoë K. Hanson

		 	Name:	 	Zoë K. Hanson
		 	Title:	 	Director



  
 Horizon –
October 2016 Bond Offering - Indenture 








 
					
	HORIZON PHARMA FINANCE S.À R.L
	Société à responsabilité limitée
	Registered office : 19, rue de Bitbourg, L-1273 Luxembourg
	R.C.S. Luxembourg : B 186.460
		
	By:	 	 /s/ David G. Kelly

		 	Name:	 	David G. Kelly
		 	Title:	 	Director



  
 Horizon –
October 2016 Bond Offering - Indenture 








 
					
	HORIZON PHARMA INVESTMENT LIMITED
		
	By:	 	 /s/ David G. Kelly

		 	Name:	 	David G. Kelly
		 	Title:	 	Director



  
 Horizon –
October 2016 Bond Offering - Indenture 








 
					
	RAPTOR PHARMACEUTICAL CORP.
		
	By:	 	 /s/ Paul W. Hoelscher

		 	Name:	 	Paul W. Hoelscher
		 	Title:	 	EVP and Chief Financial Officer
	
	RAPTOR PHARMACEUTICALS INC.
		
	By:	 	 /s/ Paul W. Hoelscher

		 	Name:	 	Paul W. Hoelscher
		 	Title:	 	EVP and Chief Financial Officer



  
 Horizon –
October 2016 Bond Offering - Indenture 








 
					
	U.S. BANK NATIONAL ASSOCIATION,
	As Trustee
		
	By:	 	 /s/ Raymond S. Haverstock

		 	Name:	 	Raymond S. Haverstock
		 	Title:	 	Vice President



  
 Horizon –
October 2016 Bond Offering - Indenture 








 EXHIBIT A 

[Face of Note] 
 [Insert the Global Note
Legend, if applicable pursuant to the provisions of the Indenture] 
 [Insert the Private Placement Legend, if applicable pursuant to the provisions
of the Indenture] 
 [Insert the Regulation S Temporary Global Note Legend, if applicable pursuant to the provisions of the Indenture] 

CUSIP/ISIN1            

 8.750% Senior Notes due 2024 
  

					
	 No.        
	  		  	$        

 HORIZON PHARMA, INC. 

HORIZON PHARMA USA, INC. 
 promises to pay to
         or registered assigns, 
 the principal sum of
         DOLLARS on November 1, 2024. 
 Interest Payment Dates: May 1 and November 1 

Record Dates: April 15 and October 15 
 Dated:

 
  

 

	1 	144A CUSIP: 44053F AA8 

 144A ISIN: US44053FAA84 

Reg S CUSIP: U44017 AA6 

Reg S ISIN: USU44017AA67 

  
 A-1 








 
					
	HORIZON PHARMA, INC.
		
	By:	 	  

		 	Name:	 	Paul W. Hoelscher
		 	Title:	 	EVP and Chief Financial Officer
	
	HORIZON PHARMA USA, INC.
		
	By:	 	  

		 	Name:	 	Paul W. Hoelscher
		 	Title:	 	EVP and Chief Financial Officer



  
 Horizon –
October 2016 Bond Offering – 144A Global Note 









			
	 This is one of the Notes referred to in the within-mentioned Indenture:

	
	 U.S. BANK NATIONAL ASSOCIATION,
 as
Trustee

		
	By:	 	  

	Authorized Signatory


  
 Horizon –
October 2016 Bond Offering – 144A Global Note 








 EXHIBIT A 

[Back of Note] 
 8.750% Senior
Notes due 2024 
 Capitalized terms used herein have the meanings assigned to them in the Indenture referred to below unless otherwise
indicated. 
 (1) INTEREST. Horizon Pharma, Inc., a Delaware corporation (the
“Company”) Horizon Pharma USA, Inc., a Delaware corporation (the “Co-Issuer” and, together with the Company, the “Issuers”), promise to pay or cause to be paid interest on the principal amount of
this Note at 8.750% per annum from October 25, 2016 until but excluding maturity. The Issuers will pay interest, semi-annually in arrears on May 1 and November 1 of each year, or if any such day is not a Business Day, on the next
succeeding Business Day (each, an “Interest Payment Date”). Interest on the Notes will accrue from the most recent date to which interest has been paid or, if no interest has been paid, from the date of issuance;
provided, that, if this Note is authenticated between a record date referred to on the face hereof and the next succeeding Interest Payment Date, interest shall accrue from such next succeeding Interest Payment Date; provided further,
that the first Interest Payment Date shall be May 1, 2017. The Issuers will pay interest (including post-petition interest in any proceeding under any Bankruptcy Law) on overdue principal at a rate that is the then applicable interest rate on
the Notes to the extent lawful; it will pay interest (including post-petition interest in any proceeding under any Bankruptcy Law) on overdue installments of interest, if any (without regard to any applicable grace period), at the same rate to the
extent lawful.
 Interest will be computed on the basis of a 360-day year comprised of twelve 30-day months. 

(2) METHOD OF PAYMENT. The Issuers will pay interest on
the Notes (except defaulted interest), if any, to the Persons who are registered Holders of Notes at the close of business on the April 15 and October 15 next preceding the Interest Payment Date, even if such Notes are canceled after such
record date and on or before such Interest Payment Date, except as provided in Section 2.12 of the Indenture with respect to defaulted interest. The Notes will be payable as to principal, premium, if any, and interest at the office or
agency of the Paying Agent and Registrar within the City and State of New York, or, at the option of the Issuers, payment of interest, if any, may be made by check mailed to the Holders at their addresses set forth in the register of Holders;
provided, that payment by wire transfer of immediately available funds will be required with respect to principal of, premium on, if any, and interest on, all Global Notes and all other Notes the Holders of which will have provided wire
transfer instructions to the Issuers or the Paying Agent at least five Business Days prior to the applicable Payment Date. Such payment will be in such coin or currency of the United States of America as at the time of payment is legal tender
for payment of public and private debts. 
 (3) PAYING AGENT AND
REGISTRAR. Initially, U.S. Bank National Association, the Trustee under the Indenture, will act as Paying Agent and Registrar. The Issuers may change the Paying Agent or Registrar without prior notice to
the Holders of the Notes. The Issuers or any of their respective Subsidiaries may act as Paying Agent or Registrar. 

(4) INDENTURE. The Issuers issued the Notes under an Indenture, dated as October 25,
2016 (the “Indenture”), among the Issuers and the Trustee. The terms of the Notes include those stated in the Indenture. The Notes are subject to all such terms, and Holders are referred to


  
 A-1 








 
the Indenture and such Act for a statement of such terms. To the extent any provision of this Note conflicts with the express provisions of the Indenture, the provisions of the Indenture
shall govern and be controlling. The Notes are unsecured obligations of the Issuer. The Indenture does not limit the aggregate principal amount of Notes that may be issued thereunder. 

(5) OPTIONAL REDEMPTION. 

(a) At any time prior to November 1, 2019, the Issuers may on any one or more occasions redeem up to 35% of the aggregate
principal amount of the Notes issued under the Indenture at a redemption price equal to 108.750% of the aggregate principal amount of the Notes redeemed, plus accrued and unpaid interest to, but not including, the date of redemption (subject to the
rights of Holders of Notes on the relevant record date to receive interest due on the relevant interest payment date if the Notes have not been redeemed or repurchased prior to such date), with the net cash proceeds of an Equity Offering;
provided that: 
 (1) at least 65% of the aggregate principal amount of Notes originally issued under this Indenture
(excluding Notes held by the Parent and its Subsidiaries) remains outstanding immediately after the occurrence of such redemption; and 

(2) the redemption occurs within 180 days of the date of the closing of such Equity Offering. 

(b) At any time prior to November 1, 2019, the Issuers may on any one or more occasions redeem all or a part of the Notes at a
redemption price equal to 100% of the principal amount of the Notes redeemed, plus the Applicable Premium as of, and accrued and unpaid interest to, but not including, the date of redemption, subject to the rights of Holders of Notes on the relevant
record date to receive interest due on the relevant interest payment date if the notes have not been redeemed or repurchased prior to such date. 

(c) Except pursuant to this paragraph 5 and paragraph 7 below, the Notes will not be redeemable at the Issuers’ option
prior to November 1, 2019. 
 (d) On or after November 1, 2019, the Issuers may on any one or more occasions redeem all or a
part of the Notes at the redemption prices (expressed as percentages of principal amount) set forth below, plus accrued and unpaid interest, on the Notes redeemed, to, but not including, the applicable date of redemption, if redeemed during the
twelve-month period beginning on November 1 of the years indicated below (subject to the rights of Holders on the relevant record date to receive interest due on the relevant interest payment date if the Notes have not been redeemed or
repurchased prior to such date): 
  

					
	 Year
	  	Percentage	 
	 2019
	  	 	106.563	% 
	 2020
	  	 	104.375	% 
	 2021
	  	 	102.188	% 
	 2022 and thereafter
	  	 	100.000	% 

 Unless the Issuers default in the payment of the redemption price, interest will cease to
accrue on the Notes or portions thereof called for redemption on the applicable redemption date. 
 (6)
MANDATORY REDEMPTION. The Issuers are not required to make mandatory redemption or sinking fund payments with respect to the Notes. 

  
 Horizon –
October 2016 Bond Offering – 144A Global Note 








 (7) REDEMPTION FOR CHANGES
IN TAXES. The Issuers may redeem the Notes, in whole but not in part, at a redemption price equal to 100% of the principal amount of the Notes redeemed, plus accrued and
unpaid interest to, but not including, the Tax Redemption Date pursuant to Section 3.10 of the Indenture. 
 (8)
REPURCHASE AT THE OPTION OF HOLDER. 

(a) If there is a Change of Control, the Issuers will be required to make an offer (a “Change of Control
Offer”) to each Holder to repurchase all or any part (equal to $200,000 or an integral multiple of $1,000 in excess thereof) of each Holder’s Notes at a purchase price in cash equal to 101% of the aggregate principal amount of Notes
repurchased, plus accrued and unpaid interest on the Notes repurchased to, but not including, the date of purchase (subject to the rights of holders of Notes on the relevant record date to receive interest due on the relevant interest payment date
if the Notes have not been redeemed or repurchased prior to such date) (the “Change of Control Payment”). Within 30 days following any Change of Control, the Issuers will deliver a notice to each Holder setting forth the
procedures governing the Change of Control Offer as required by the Indenture. 
 (b) The Issuers may be required to make an
offer to purchase Notes in the event of an Asset Sale as set forth in Section 4.10 of the Indenture. 
 (9)
NOTICE OF REDEMPTION. At least 30 days but not more than 60 days before a redemption date, the Issuers will deliver or cause to be delivered a notice of redemption to each
Holder whose Notes are to be redeemed at its registered address, except that redemption notices may be delivered more than 60 days prior to a redemption date if the notice is issued in connection with a defeasance of the Notes or a satisfaction and
discharge of the Indenture pursuant to Articles 8 or 11 thereof. Notes and portions of Notes selected will be in amounts of $200,000 or whole multiples of $1,000 in excess thereof; except that if all of the Notes of a Holder are to be redeemed
or purchased, the entire outstanding amount of Notes held by such Holder shall be redeemed or purchased. 
 (10)
[RESERVED] 
 (11) DENOMINATIONS, TRANSFER,
EXCHANGE. The Notes are in registered form in denominations of $200,000 and integral multiples of $1,000 in excess thereof. The transfer of Notes may be registered and Notes may be exchanged as provided in
the Indenture. The Registrar and the Trustee may require a Holder, among other things, to furnish appropriate endorsements and transfer documents and the Issuers may require a Holder to pay any taxes and fees required by law or permitted by the
Indenture. The Issuers need not exchange or register the transfer of any Note or portion of a Note selected for redemption, except for the unredeemed portion of any Note being redeemed in part. Also, the Issuers need not exchange or
register the transfer of any Notes for a period of 15 days before the delivering of any notice of redemption or during the period between a record date and the next succeeding Interest Payment Date. 

[IN THE CASE OF REGULATION S TEMPORARY GLOBAL NOTE: This Regulation S Temporary Global Note is exchangeable in whole or
in part for one or more Global Notes only (i) on or after the termination of the 40-day distribution compliance period (as defined in Regulation S) and (ii) upon presentation of certificates (accompanied by an Opinion of Counsel, if applicable)
required by Article 2 of the Indenture. Upon exchange of this Regulation S Temporary Global Note for one or more Global Notes, the Trustee shall cancel this Regulation S Temporary Global Note.] 

  
 Horizon –
October 2016 Bond Offering – 144A Global Note 








 (12) PERSONS DEEMED
OWNERS. The registered Holder of a Note may be treated as the owner of it for all purposes. Only registered Holders have rights under the Indenture.

(13) AMENDMENT, SUPPLEMENT AND
WAIVER. Subject to certain exceptions, the Indenture, the Notes or the Note Guarantees may be amended or supplemented with the consent of the Holders of at least a majority in aggregate principal amount of the
then outstanding Notes including Additional Notes, if any, voting as a single class. Without the consent of any Holder of Notes, the Indenture, the Notes or the Note Guarantees may be amended or supplemented as provided in the Indenture. 

(14) DEFAULTS AND REMEDIES. If an Event of Default
(other than an Event of Default specified in Section 6.01(7) and 6.01(8) of the Indenture with respect to the Parent or the Issuer) shall have occurred and be continuing, either the Trustee or the Holders of at least 25% of the outstanding principal
amount of the Notes may declare to be immediately due and payable the principal amount of all such Notes then outstanding, plus accrued but unpaid interest to the date of acceleration. Upon the effectiveness of such a declaration, such
principal, premium, accrued and unpaid interest, and other monetary obligations shall be due and payable immediately. If an Event of Default specified in Sections 6.01(7) and 6.01(8) of the Indenture with respect to the Parent or the Issuers
shall occur, such amounts with respect to all the Notes shall become automatically due and payable immediately without any further action or notice. The Holders of a majority in aggregate principal amount of the then outstanding Notes by notice
to the Trustee may, on behalf of all the Holders, rescind an acceleration or waive an existing Default or Event of Default and its respective consequences under the Indenture except a continuing Default or Event of Default in the payment of
principal of, premium on, if any, or interest on, the Notes (including in connection with an offer to purchase). 
 (15)
TRUSTEE DEALINGS WITH ISSUER. The Trustee, in its individual or any other capacity, may make loans to, accept deposits from, and perform services for the Issuers
or their respective Affiliates, and may otherwise deal with the Issuers or their respective Affiliates, as if it were not the Trustee. 

(16) NO RECOURSE AGAINST OTHERS. No
director, officer, employee, incorporator or stockholder of the Issuers or any Guarantor, as such, will have any liability for any obligations of the Issuers or the Guarantors under the Notes, the Indenture, the Note Guarantees or for any claim
based on, in respect of, or by reason of, such obligations or their creation. Each Holder of Notes by accepting a Note waives and releases all such liability. The waiver and release are part of the consideration for issuance of the
Notes. The waiver may not be effective to waive liabilities under the federal securities laws. 
 (17)
AUTHENTICATION. This Note will not be valid until authenticated by the manual signature of the Trustee or an authenticating agent. 

(18) ABBREVIATIONS. Customary abbreviations may be used in the name of a Holder or an
assignee, such as: TEN COM (= tenants in common), TEN ENT (= tenants by the entireties), JT TEN (= joint tenants with right of survivorship and not as tenants in common), CUST (= Custodian), and U/G/M/A (= Uniform Gifts to Minors Act). 

(19) CUSIP OR ISIN NUMBERS. Pursuant to a recommendation promulgated
by the Committee on Uniform Security Identification Procedures, the Issuers have caused CUSIP or ISIN numbers to be printed on the Notes, and the Trustee may use CUSIP or ISIN numbers in notices of redemption as a convenience to Holders. No
representation is made as to the accuracy of such numbers either as printed on the Notes or as contained in any notice of redemption, and reliance may be placed only on the other identification numbers placed thereon. 

  
 Horizon –
October 2016 Bond Offering – 144A Global Note 








 (20) GOVERNING LAW. THE INDENTURE, THIS NOTE AND THE NOTE GUARANTEES
SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. THE ISSUERS, THE TRUSTEE AND EACH OF THE GUARANTORS HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO
TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THE INDENTURE, THIS NOTE OR THE TRANSACTIONS CONTEMPLATED THEREBY OR HEREBY. 

The Issuers will furnish to any Holder upon written request and without charge a copy of the Indenture. Requests may be made to: 

Horizon Pharma, Inc. 
 Horizon
Pharma USA, Inc. 
 c/o Horizon Pharma Public Limited Company 

Connaught House, 1st Floor 
 1
Burlington Road 
 Dublin 4, Ireland 

Attention: Treasurer 

  
 Horizon –
October 2016 Bond Offering – 144A Global Note 








 ASSIGNMENT FORM 

To assign this Note, fill in the form below: 
  

			
	(I) or (we) assign and transfer this Note to:	 	  

		 	(Insert assignee’s legal name)

  
  

(Insert assignee’s soc. sec. or tax I.D. no.) 
  

 
  

 
  

 
  

 
 (Print or type assignee’s name,
address and zip code) 
  

			
	and irrevocably appoint	 	  


 to transfer this Note on the books of the Issuer. The agent may substitute another to act for him. 

 

			
	Date:	 	  



 

			
	Your Signature:	 	  



 
			
	(Sign exactly as your name appears on the face of this Note)



 

			
	Signature Guarantee*:	 	  


  

	*	Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor acceptable to the Trustee). 


  
 Horizon –
October 2016 Bond Offering – 144A Global Note 








 Option of Holder to Elect Purchase 

If you want to elect to have this Note purchased by the Issuers pursuant to Section 4.10 or 4.14 of the Indenture, check the appropriate box
below: 
  

							
		 	☐ Section 4.10	 	☐ Section 4.14	 	

 If you want to elect to have only part of the Note purchased by the Issuers pursuant to Section 4.10 or
Section 4.14 of the Indenture, state the amount you elect to have purchased: 
 $         

 

			
	Date:	 	  


  

			
	Your Signature:	 	  



 
			
	(Sign exactly as your name appears on the face of this Note)



 

			
	Tax Identification No.:	 	  



  

			
	Signature Guarantee*:	 	  


  

	*	Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor acceptable to the Trustee). 


  
 Horizon –
October 2016 Bond Offering – 144A Global Note 








 SCHEDULE OF EXCHANGES OF
INTERESTS IN THE GLOBAL NOTE * 
 The following exchanges of a
part of this Global Note for an interest in another Global Note or for a Definitive Note, or exchanges of a part of another Global Note or Definitive Note for an interest in this Global Note, have been made: 

 

																	
	 Date of Exchange
	  	Amount of
decrease in
Principal Amount
of
this Global Note	 	  	Amount of
increase in
Principal Amount
of
this Global Note	 	  	Principal Amount
of this Global Note
following such
decrease
(or increase)	 	  	Signature of
authorized
signatory of
Trustee or
Custodian	 
		  				  				  				  			
		  				  				  				  			
		  				  				  				  			

  

	*	This schedule should be included only if the Note is issued in global form. 


  
 Horizon –
October 2016 Bond Offering – 144A Global Note 








 EXHIBIT B 

FORM OF CERTIFICATE OF TRANSFER 
 Horizon Pharma,
Inc. 
 Horizon Pharma USA, Inc. 
 c/o Horizon Pharma Public
Limited Company. 
 Connaught House, 1st Floor 1 Burlington Road 

Dublin 4, Ireland 
 U.S. Bank National Association 

Corporate Trust Services 
 West Side Flats 

60 Livingston Avenue 
 St. Paul MN 55107-1419 

Fax: (651) 466-7430 
 Attention: Raymond S. Haverstock 

Re: 8.750% Senior Notes due 2024 

Reference is hereby made to the Indenture, dated as of October 25, 2016 (the “Indenture”), among Horizon Pharma, Inc. (the
“Company), Horizon Pharma USA, Inc. (the “Co-Issuer” and, together with the Company, the “Issuers”), the Guarantors party thereto and U.S. Bank National Association, as trustee. Capitalized terms
used but not defined herein shall have the meanings given to them in the Indenture. 

                    , (the
“Transferor”) owns and proposes to transfer the Note[s] or interest in such Note[s] specified in Annex A hereto, in the principal amount of $         in such Note[s] or interests (the
“Transfer”), to                      (the “Transferee”), as further specified in Annex A
hereto. In connection with the Transfer, the Transferor hereby certifies that: 
 [CHECK ALL THAT APPLY] 

1. ☐ Check if Transferee will take delivery of a beneficial interest in the 144A Global Note or a Restricted Definitive
Note pursuant to Rule 144A. The Transfer is being effected pursuant to and in accordance with Rule 144A under the Securities Act of 1933, as amended (the “Securities Act”), and, accordingly, the Transferor hereby
further certifies that the beneficial interest or Definitive Note is being transferred to a Person that the Transferor reasonably believes is purchasing the beneficial interest or Definitive Note for its own account, or for one or more accounts with
respect to which such Person exercises sole investment discretion, and such Person and each such account is a “qualified institutional buyer” within the meaning of Rule 144A in a transaction meeting the requirements of Rule 144A, and such
Transfer is in compliance with any applicable blue sky securities laws of any state of the United States. Upon consummation of the proposed Transfer in accordance with the terms of the Indenture, the transferred beneficial interest or
Definitive Note will be subject to the restrictions on transfer enumerated in the Private Placement Legend printed on the 144A Global Note and/or the Restricted Definitive Note and in the Indenture and the Securities Act. 

2. ☐ Check if Transferee will take delivery of a beneficial interest in the Regulation S Temporary Global Note, the
Regulation S Permanent Global Note or a Restricted Definitive Note pursuant to Regulation S. The Transfer is being effected pursuant to and in accordance with Rule 903 or Rule 904 under the Securities Act and, accordingly, the
Transferor hereby further certifies that (i) the 

  
 B-1 








 
Transfer is not being made to a Person in the United States and (x) at the time the buy order was originated, the Transferee was outside the United States or such Transferor and any Person acting
on its behalf reasonably believed and believes that the Transferee was outside the United States or (y) the transaction was executed in, on or through the facilities of a designated offshore securities market and neither such Transferor nor any
Person acting on its behalf knows that the transaction was prearranged with a buyer in the United States, (ii) no directed selling efforts have been made in contravention of the requirements of Rule 903(b) or Rule 904(b) of Regulation S under the
Securities Act (iii) the transaction is not part of a plan or scheme to evade the registration requirements of the Securities Act and (iv) if the proposed transfer is being made prior to the expiration of the distribution compliance period (as
defined in Regulation S), the transfer is not being made to a U.S. Person or for the account or benefit of a U.S. Person (other than an Initial Purchaser). Upon consummation of the proposed transfer in accordance with the terms of the
Indenture, the transferred beneficial interest or Definitive Note will be subject to the restrictions on Transfer enumerated in the Private Placement Legend printed on the Regulation S Temporary Global Note, Regulation S Permanent Global Note and/or
the Restricted Definitive Note and in the Indenture and the Securities Act. 
 3. ☐ Check and complete if Transferee
will take delivery of a beneficial interest in the IAI Global Note or a Restricted Definitive Note pursuant to any provision of the Securities Act other than Rule 144A or Regulation S. The Transfer is being effected in compliance with
the transfer restrictions applicable to beneficial interests in Restricted Global Notes and Restricted Definitive Notes and pursuant to and in accordance with the Securities Act and any applicable blue sky securities laws of any state of the United
States, and accordingly the Transferor hereby further certifies that (check one): 
 (a) ☐ such Transfer is being effected
pursuant to and in accordance with Rule 144 under the Securities Act; 
 or 

(b) ☐ such Transfer is being effected to the Issuers or a subsidiary thereof; 

or 
 (c) ☐ such
Transfer is being effected pursuant to an effective registration statement under the Securities Act and in compliance with the prospectus delivery requirements of the Securities Act; 

or 
 (d) ☐ such
Transfer is being effected to an Institutional Accredited Investor and pursuant to an exemption from the registration requirements of the Securities Act other than Rule 144A, Rule 144, Rule 903 or Rule 904, and the Transferor hereby further
certifies that it has not engaged in any general solicitation within the meaning of Regulation D under the Securities Act and the Transfer complies with the transfer restrictions applicable to beneficial interests in a Restricted Global Note or
Restricted Definitive Notes and the requirements of the exemption claimed, which certification is supported by (1) a certificate executed by the Transferee in the form of Exhibit D to the Indenture and (2) if such Transfer is in respect of a
principal amount of Notes at the time of transfer of less than $250,000, an Opinion of Counsel provided by the Transferor or the Transferee (a copy of which the Transferor has attached to this certification), to the effect that such Transfer is in
compliance with the Securities Act. Upon consummation of the proposed transfer in accordance with the terms of the Indenture, the transferred beneficial interest or Definitive Note will be subject to the restrictions on transfer enumerated in
the Private Placement Legend printed on the IAI Global Note and/or the Restricted Definitive Notes and in the Indenture and the Securities Act. 

  
 B-2 








 4. ☐ Check if Transferee will take delivery of a beneficial interest in an
Unrestricted Global Note or of an Unrestricted Definitive Note. 
 (a) ☐ Check if Transfer is pursuant to Rule
144. (i) The Transfer is being effected pursuant to and in accordance with Rule 144 under the Securities Act and in compliance with the transfer restrictions contained in the Indenture and any applicable blue sky securities laws of any
state of the United States and (ii) the restrictions on transfer contained in the Indenture and the Private Placement Legend are not required in order to maintain compliance with the Securities Act. Upon consummation of the proposed Transfer in
accordance with the terms of the Indenture, the transferred beneficial interest or Definitive Note will no longer be subject to the restrictions on transfer enumerated in the Private Placement Legend printed on the Restricted Global Notes, on
Restricted Definitive Notes and in the Indenture. 
 (b) ☐ Check if Transfer is Pursuant to Regulation S. (i) The
Transfer is being effected pursuant to and in accordance with Rule 903 or Rule 904 under the Securities Act and in compliance with the transfer restrictions contained in the Indenture and any applicable blue sky securities laws of any state of the
United States and (ii) the restrictions on transfer contained in the Indenture and the Private Placement Legend are not required in order to maintain compliance with the Securities Act. Upon consummation of the proposed Transfer in accordance
with the terms of the Indenture, the transferred beneficial interest or Definitive Note will no longer be subject to the restrictions on transfer enumerated in the Private Placement Legend printed on the Restricted Global Notes, on Restricted
Definitive Notes and in the Indenture. 
 (c) ☐ Check if Transfer is Pursuant to Other Exemption. (i) The Transfer is
being effected pursuant to and in compliance with an exemption from the registration requirements of the Securities Act other than Rule 144, Rule 903 or Rule 904 and in compliance with the transfer restrictions contained in the Indenture and any
applicable blue sky securities laws of any State of the United States and (ii) the restrictions on transfer contained in the Indenture and the Private Placement Legend are not required in order to maintain compliance with the Securities
Act. Upon consummation of the proposed Transfer in accordance with the terms of the Indenture, the transferred beneficial interest or Definitive Note will not be subject to the restrictions on transfer enumerated in the Private Placement Legend
printed on the Restricted Global Notes or Restricted Definitive Notes and in the Indenture. 
 This certificate and the statements contained
herein are made for your benefit and the benefit of the Issuer. 
  

			
	  

		 	[Insert Name of Transferor]
		
	By:	 	  

		 	Name:
		 	Title:


  

			
	          Dated:	 	  



  
 B-3 








 EXHIBIT C 

FORM OF CERTIFICATE OF EXCHANGE 
 Horizon Pharma,
Inc. 
 Horizon Pharma USA, Inc. 
 c/o Horizon Pharma Public
Limited Company. 
 Connaught House, 1st Floor 
 1 Burlington
Road 
 Dublin 4, Ireland 
 U.S. Bank National Association 

Corporate Trust Services 
 West Side Flats 

60 Livingston Avenue 
 St. Paul MN 55107-1419 

Fax: (651) 466-7430 
 Attention: Raymond S. Haverstock 

Re: 8.750% Senior Notes due 2024 

(CUSIP [        ]) 

Reference is hereby made to the Indenture, dated as of October 25, 2016 (the “Indenture”), among Horizon Pharma, Inc. (the
“Company), Horizon Pharma USA, Inc. (the “Co-Issuer” and, together with the Company, the “Issuers”), the Guarantors party thereto and U.S. Bank National Association, as trustee. Capitalized terms
used but not defined herein shall have the meanings given to them in the Indenture. 

                    , (the
“Owner”) owns and proposes to exchange the Note[s] or interest in such Note[s] specified herein, in the principal amount of $         in such Note[s] or interests (the
“Exchange”). In connection with the Exchange, the Owner hereby certifies that: 
 1. Exchange of Restricted
Definitive Notes or Beneficial Interests in a Restricted Global Note for Unrestricted Definitive Notes or Beneficial Interests in an Unrestricted Global Note 

(a) ☐ Check if Exchange is from beneficial interest in a Restricted Global Note to beneficial interest in an Unrestricted Global
Note. In connection with the Exchange of the Owner’s beneficial interest in a Restricted Global Note for a beneficial interest in an Unrestricted Global Note in an equal principal amount, the Owner hereby certifies (i) the beneficial
interest is being acquired for the Owner’s own account without transfer, (ii) such Exchange has been effected in compliance with the transfer restrictions applicable to the Global Notes and pursuant to and in accordance with the Securities Act
of 1933, as amended (the “Securities Act”), (iii) the restrictions on transfer contained in the Indenture and the Private Placement Legend are not required in order to maintain compliance with the Securities Act and (iv) the
beneficial interest in an Unrestricted Global Note is being acquired in compliance with any applicable blue sky securities laws of any state of the United States. 

(b) ☐ Check if Exchange is from beneficial interest in a Restricted Global Note to Unrestricted Definitive Note. In
connection with the Exchange of the Owner’s beneficial interest in a Restricted Global Note for an Unrestricted Definitive Note, the Owner hereby certifies (i) the Definitive Note is being acquired for the Owner’s own account without
transfer, (ii) such Exchange has been effected in compliance with the transfer restrictions applicable to the Restricted Global Notes and pursuant to and in accordance with the Securities Act, (iii) the restrictions on transfer contained in the


  
 C-1 








 
Indenture and the Private Placement Legend are not required in order to maintain compliance with the Securities Act and (iv) the Definitive Note is being acquired in compliance with any
applicable blue sky securities laws of any state of the United States. 
 (c) ☐ Check if Exchange is from Restricted Definitive
Note to beneficial interest in an Unrestricted Global Note. In connection with the Owner’s Exchange of a Restricted Definitive Note for a beneficial interest in an Unrestricted Global Note, the Owner hereby certifies (i) the beneficial
interest is being acquired for the Owner’s own account without transfer, (ii) such Exchange has been effected in compliance with the transfer restrictions applicable to Restricted Definitive Notes and pursuant to and in accordance with the
Securities Act, (iii) the restrictions on transfer contained in the Indenture and the Private Placement Legend are not required in order to maintain compliance with the Securities Act and (iv) the beneficial interest is being acquired in compliance
with any applicable blue sky securities laws of any state of the United States. 
 (d) ☐ Check if Exchange is from Restricted
Definitive Note to Unrestricted Definitive Note. In connection with the Owner’s Exchange of a Restricted Definitive Note for an Unrestricted Definitive Note, the Owner hereby certifies (i) the Unrestricted Definitive Note is being
acquired for the Owner’s own account without transfer, (ii) such Exchange has been effected in compliance with the transfer restrictions applicable to Restricted Definitive Notes and pursuant to and in accordance with the Securities Act, (iii)
the restrictions on transfer contained in the Indenture and the Private Placement Legend are not required in order to maintain compliance with the Securities Act and (iv) the Unrestricted Definitive Note is being acquired in compliance with any
applicable blue sky securities laws of any state of the United States. 
 2. Exchange of Restricted Definitive Notes or Beneficial
Interests in Restricted Global Notes for Restricted Definitive Notes or Beneficial Interests in Restricted Global Notes 
 (a)
☐ Check if Exchange is from beneficial interest in a Restricted Global Note to Restricted Definitive Note. In connection with the Exchange of the Owner’s beneficial interest in a Restricted Global Note for a Restricted
Definitive Note with an equal principal amount, the Owner hereby certifies that the Restricted Definitive Note is being acquired for the Owner’s own account without transfer. Upon consummation of the proposed Exchange in accordance with
the terms of the Indenture, the Restricted Definitive Note issued will continue to be subject to the restrictions on transfer enumerated in the Private Placement Legend printed on the Restricted Definitive Note and in the Indenture and the
Securities Act. 
 (b) ☐ Check if Exchange is from Restricted Definitive Note to beneficial interest in a Restricted Global
Note. In connection with the Exchange of the Owner’s Restricted Definitive Note for a beneficial interest in the [CHECK ONE] ☐ 144A Global Note, ☐ Regulation S Global Note, ☐ IAI Global Note with an equal
principal amount, the Owner hereby certifies (i) the beneficial interest is being acquired for the Owner’s own account without transfer and (ii) such Exchange has been effected in compliance with the transfer restrictions applicable to the
Restricted Global Notes and pursuant to and in accordance with the Securities Act, and in compliance with any applicable blue sky securities laws of any state of the United States. Upon consummation of the proposed Exchange in accordance with
the terms of the Indenture, the beneficial interest issued will be subject to the restrictions on transfer enumerated in the Private Placement Legend printed on the relevant Restricted Global Note and in the Indenture and the Securities Act. 

  
 C-2 








 This certificate and the statements contained herein are made for your benefit and the benefit of
the Issuer. 
  

			
	  

	[Insert Name of Transferor]
		
	By:	 	  

		 	Name:
		 	Title:


  

			
	Dated:	 	  



  
 C-3 








 EXHIBIT D 

FORM OF CERTIFICATE FROM 

ACQUIRING INSTITUTIONAL ACCREDITED INVESTOR 

Horizon Pharma, Inc. 
 Horizon Pharma USA, Inc. 

c/o Horizon Pharma Public Limited Company 
 Connaught House, 1st
Floor 
 1 Burlington Road 
 Dublin 4, Ireland 

U.S. Bank National Association 
 Corporate Trust Services 

West Side Flats 
 60 Livingston Avenue 

St. Paul MN 55107-1419 
 Fax: (651) 466-7430 

Attention: Raymond S. Haverstock 

Re: 8.750% Senior Notes due 2024 

Reference is hereby made to the Indenture, dated as of October 25, 2016 (the “Indenture”), among Horizon Pharma, Inc. (the
“Company), Horizon Pharma USA, Inc. (the “Co-Issuer” and, together with the Company, the “Issuers”), the Guarantors party thereto and U.S. Bank National Association, as trustee. Capitalized terms
used but not defined herein shall have the meanings given to them in the Indenture. 
 In connection with our proposed purchase of
$         aggregate principal amount of: 
 (a) ☐ a beneficial interest in a Global
Note, or 
 (b) ☐ a Definitive Note, 

we confirm that: 
 1. We
understand that any subsequent transfer of the Notes or any interest therein is subject to certain restrictions and conditions set forth in the Indenture and the undersigned agrees to be bound by, and not to resell, pledge or otherwise transfer the
Notes or any interest therein except in compliance with, such restrictions and conditions and the Securities Act of 1933, as amended (the “Securities Act”). 

2. We understand that the offer and sale of the Notes have not been registered under the Securities Act, and that the Notes and any interest
therein may not be offered or sold except as permitted in the following sentence. We agree, on our own behalf and on behalf of any accounts for which we are acting as hereinafter stated, that if we should sell the Notes or any interest therein,
we will do so only (A) to the Issuers or any subsidiary thereof, (B) in accordance with Rule 144A under the Securities Act to a “qualified institutional buyer” (as defined therein), (C) to an institutional “accredited investor”
(as defined below) that, prior to such transfer, furnishes (or has furnished on its behalf by a U.S. broker-dealer) to you and to the Issuers a signed letter substantially in the form of this letter and, if such transfer is in respect of a principal
amount of Notes, at the time of transfer of less than $250,000, an Opinion of Counsel in form reasonably acceptable to the Issuers to the effect that such transfer is in compliance with the Securities Act, (D) outside the United States in accordance
with Rule 904 of Regulation S under the Securities Act, 

  
 D-1 








 
(E) pursuant to the provisions of Rule 144 under the Securities Act or (F) pursuant to an effective registration statement under the Securities Act, and we further agree to provide to any Person
purchasing the Definitive Note or beneficial interest in a Global Note from us in a transaction meeting the requirements of clauses (A) through (E) of this paragraph a notice advising such purchaser that resales thereof are restricted as stated
herein. 
 3. We understand that, on any proposed resale of the Notes or beneficial interest therein, we will be required to furnish to you
and the Issuers such certifications, legal opinions and other information as you and the Issuers may reasonably require to confirm that the proposed sale complies with the foregoing restrictions. We further understand that the Notes purchased
by us will bear a legend to the foregoing effect. 
 4. We are an institutional “accredited investor” (as defined in Rule
501(a)(1), (2), (3) or (7) of Regulation D under the Securities Act) and have such knowledge and experience in financial and business matters as to be capable of evaluating the merits and risks of our investment in the Notes, and we and any accounts
for which we are acting are each able to bear the economic risk of our or its investment. 
 5. We are acquiring the Notes or beneficial
interest therein purchased by us for our own account or for one or more accounts (each of which is an institutional “accredited investor”) as to each of which we exercise sole investment discretion. 

You and the Issuers are entitled to rely upon this letter and are irrevocably authorized to produce this letter or a copy hereof to any
interested party in any administrative or legal proceedings or official inquiry with respect to the matters covered hereby. 
  

			
	  

	[Insert Name of Accredited Investor]
		
	By:	 	  

		 	Name:
		 	Title:


  

			
	Dated:	 	  



  
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 EXHIBIT E 

[FORM OF SUPPLEMENTAL INDENTURE 

TO BE DELIVERED BY SUBSEQUENT GUARANTORS] 

SUPPLEMENTAL INDENTURE (this “Supplemental Indenture”), dated as of
                    , among
                     (the “Guaranteeing Entity”), a parent or subsidiary of Horizon Pharma, Inc. (or its permitted
successor), a Delaware corporation (the “Company”), Horizon Pharma USA, Inc. (or its permitted successor), a Delaware corporation (the “Co-Issuer” and, together with the Company, the “Issuers”), the
Issuers, the other Guarantors (as defined in the Indenture referred to herein) and U.S. Bank National Association, as trustee under the Indenture referred to below (the “Trustee”). 

W I T N E S S E T H 
 WHEREAS,
the Issuers have heretofore executed and delivered to the Trustee an indenture (the “Indenture”), dated as of October 25, 2016 providing for the issuance of 8.750% Senior Notes due 2024 (the “Notes”); 

WHEREAS, the Indenture provides that under certain circumstances the Guaranteeing Entity shall execute and deliver to the Trustee a
supplemental indenture pursuant to which the Guaranteeing Entity shall unconditionally guarantee all of the Issuers’ Obligations under the Notes and the Indenture on the terms and conditions set forth herein (the “Note
Guarantee”); and 
 WHEREAS, pursuant to Section 9.01 of the Indenture, the Trustee is authorized to execute and deliver this
Supplemental Indenture. 
 NOW, THEREFORE, in consideration of the foregoing and for other good and valuable consideration, the receipt of
which is hereby acknowledged, the Guaranteeing Entity and the Trustee mutually covenant and agree for the equal and ratable benefit of the Holders of the Notes as follows: 

1. CAPITALIZED TERMS. Capitalized terms used herein without definition shall have the meanings assigned to
them in the Indenture. 
 2. AGREEMENT TO GUARANTEE. The Guaranteeing Entity hereby agrees
to provide an unconditional Guarantee on the terms and subject to the conditions set forth in the Note Guarantee and in the Indenture including but not limited to Article 10 thereof. 

4. NO RECOURSE AGAINST OTHERS. No director, officer, employee, incorporator
or stockholder of the Issuers or any Guarantor, as such, will have any liability for any obligations of the Company or the Guarantors under the Notes, this Indenture, the Note Guarantees or for any claim based on, in respect of, or by reason of,
such obligations or their creation. Each Holder of Notes by accepting a Note waives and releases all such liability. The waiver and release are part of the consideration for issuance of the Notes. The waiver may not be effective to
waive liabilities under the federal securities laws. 
 5. NEW YORK LAW TO GOVERN; WAIVER OF JURY TRIAL. THIS SUPPLEMENTAL INDENTURE
SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. EACH OF THE ISSUERS AND THE GUARANTORS CONSENTS AND IRREVOCABLY SUBMITS TO THE JURISDICTION OF ANY NEW YORK STATE OR U.S. FEDERAL COURT LOCATED IN THE
BOROUGH OF MANHATTAN, CITY OF NEW YORK, COUNTY OF NEW YORK, STATE OF 

  
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NEW YORK IN RELATION TO ANY LEGAL ACTION OR PROCEEDING (I) ARISING OUT OF, RELATING TO OR IN CONNECTION WITH THIS INDENTURE, AS SUPPLEMENTED, THE NOTES, THE GUARANTEES AND ANY RELATED
DOCUMENTS AND/OR (II) ARISING UNDER ANY U.S. FEDERAL OR U.S. STATE SECURITIES LAWS IN RESPECT OF THE NOTES, THE GUARANTEES AND ANY SECURITIES ISSUED PURSUANT TO THE TERMS OF THE INDENTURE, AS SUPPLEMENTED. EACH OF THE ISSUERS AND THE
GUARANTORS WAIVES ANY OBJECTION TO PROCEEDINGS IN ANY SUCH COURTS, WHETHER ON THE GROUND OF VENUE OR ON THE GROUND THAT THE PROCEEDINGS HAVE BEEN BROUGHT IN AN INCONVENIENT FORUM. EACH OF THE ISSUERS AND THE GUARANTORS, TO THE EXTENT ORGANIZED
OUTSIDE OF THE UNITED STATES, SHALL APPOINT HORIZON PHARMA, INC. (HORIZON PHARMA, INC., 150 S SAUNDERS ROAD, LAKE FOREST, IL 60045), AS ITS AGENT FOR SERVICE OF PROCESS IN ANY SUCH SUIT, ACTION OR PROCEEDING AND AGREES THAT SERVICE OF PROCESS UPON
SAID AUTHORIZED AGENT SHALL BE DEEMED IN EVERY RESPECT EFFECTIVE SERVICE OF PROCESS UPON IT IN ANY SUCH SUIT, ACTION OR PROCEEDING. EACH OF THE ISSUERS AND THE GUARANTORS AGREES TO DELIVER, UPON THE EXECUTION AND DELIVERY OF THIS SUPPLEMENTAL
INDENTURE, A WRITTEN ACCEPTANCE BY SUCH AGENT OF ITS APPOINTMENT AS SUCH AGENT. EACH OF THE ISSUERS AND THE GUARANTORS, TO THE EXTENT ORGANIZED OUTSIDE OF THE UNITED STATES, FURTHER AGREES TO TAKE ANY AND ALL ACTION, INCLUDING THE FILING OF ANY
AND ALL SUCH DOCUMENTS AND INSTRUMENTS, AS MAY BE REASONABLY NECESSARY TO CONTINUE SUCH DESIGNATION AND APPOINTMENT OF CT CORPORATION SYSTEM IN FULL FORCE AND EFFECT FOR SO LONG AS THE INDENTURE, AS SUPPLEMENTED, REMAINS IN FORCE. THE ISSUERS,
THE TRUSTEE AND EACH OF THE GUARANTORS HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS SUPPLEMENTAL INDENTURE OR THE
TRANSACTIONS CONTEMPLATED HEREBY. 
 6. COUNTERPARTS. The parties may sign any number of copies of this Supplemental
Indenture. Each signed copy (which may be provided via facsimile or other electronic transmission) shall be an original, but all of them together represent the same agreement.

7. EFFECT OF HEADINGS. The Section headings herein are for convenience only and shall not
affect the construction hereof. 
 8. THE TRUSTEE. The Trustee shall not be responsible in any manner
whatsoever for or in respect of the validity or sufficiency of this Supplemental Indenture or for or in respect of the recitals contained herein, all of which recitals are made solely by the Guaranteeing Entity and the Issuer. 

  
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 IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly
executed and attested, all as of the date first above written. 
  

			
	          Dated:	 	                                      
                                ,

  

			
	[GUARANTEEING ENTITY]
		
	By:	 	  

		 	Name:
		 	Title:
	
	[HORIZON PHARMA, INC.]
		
	By:	 	  

		 	Name:
		 	Title:
	
	[HORIZON PHARMA USA, INC.]
		
	By:	 	  

		 	Name:
		 	Title:
	
	[EXISTING GUARANTORS]
		
	By:	 	  

		 	Name:
		 	Title:
	
	 [U.S. BANK NATIONAL ASSOCIATION],

as Trustee

		
	By:	 	  

		 	Name:
		 	Title:



  
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