Appendix H::. Included and Excluded Trials

Note:  All trials are listed by trial number.

Included Trials (n=274)

1 

Adams J, Thorn P. Topical fusidic acid versus peroral doxycycline in the treatment of patients with acne

vulgaris of the face.  Curr Ther Res Clin Exp 1991;50:268-273.

2 

Adams RM, Burdick KH. An antiandrogen delta 1 chlormadinone acetate in acne: lack of effect

topically.  Acta Derm Venereol 1970;50:479-80.

3 

Agrawal P, Singh PK, Pandey SS, et al. Oral zinc in acne vulgaris (a double blind evaluation).  Indian J

Dermatol Venereol Leprol 1985;51:38-39.

4 

Akamatsu H, Nishijima S, Akamatsu M, et al. Clinical evaluation of roxithromycin in patients with acne. 

J Int Med Res 1996;24:109-14.

6 

Al Mishari MA. Clinical and bacteriological evaluation of tetracycline and erythromycin in acne

vulgaris.  Clin Ther 1987;9:273-80.

5 

Al Mishari MA. A study of isotretinoin (Roaccutan) in nodulocystic acne.  Clin Trials J 1986;23:1-5.

10 

Anderson RL, Cook CH, Smith DE. The effect of oral and topical tetracycline on acne severity and on

surface lipid composition.  J Invest Dermatol 1976;66:172-7.

13 

Anonymous. Retinoic acid in the treatment of acne. A report from the General Practitioner Research

Group.  Practitioner 1974;213:387-90.

12 

Anonymous. Vitamin A in acne vulgaris: report by the South-East Scotland Faculty of the College of

General Practitioners.  Br Med J 1963;2:294-6.

15 

Ashorn R, Uotila A, Kuokkanen K, et al. Cellular immunity in acne vulgaris during transfer factor

treatment.  Ann Clin Res 1985;17:152-5.

16 

Ashurst PJ. The treatment of acne.  A comparison of 'quinoderm' and 'quinoderm hydrocortisone' creams. 

Practitioner 1964;193:192-4.

17 

Balambal R, Thiruvengadam KV, Kameswarant L, et al. Ocimum basilicum in acne vulgaris--a

controlled comparison with a standard regime.  J Assoc Physicians of India 1985;33:507-8.

18 

Bassett IB, Pannowitz DL, Barnetson RS. A comparative study of tea-tree oil versus benzoyl peroxide in

the treatment of acne.  Med J Aust 1990;153:455-8.

19 

Becker FT, Bronstein SB, Jacobson C, et al. Clinical evaluation of 16-epiestriol-3-allyl ether in acne

vulgaris.  A collaborative study.  Arch Dermatol 1965;91:155-8.

20 

Becker LE, Bergstresser PR, Whiting DA, et al. Topical clindamycin therapy for acne vulgaris. A

cooperative clinical study.  Arch Dermatol 1981;117:482-5.

21 

Bettley FR, Dale TL. The local treatment of acne.  Br J Clin Pract 1976;30:67-9.

22 

Bladon PT, Burke BM, Cunliffe WJ, et al. Topical azelaic acid and the treatment of acne: a clinical and

laboratory comparison with oral tetracycline.  Br J Dermatol 1986;114:493-9.

23 

Blaney DJ, Cook CH. Topical use of tetracycline in the treatment of acne: a double-blind study

comparing topical and oral tetracycline therapy and placebo.  Arch Dermatol 1976;112:971-3.

25 

Bleeker J. Tolerance and efficacy of erythromycin stearate tablets versus enteric-coated erythromycin

base capsules in the treatment of patients with acne vulgaris.  J Int Med Res 1983;11:38-41.

24 

Bleeker J, Hellgren L, Vincent J. Effect of systemic erythromycin stearate on the inflammatory lesions

and skin surface fatty acids in acne vulgaris.  Dermatologica 1981;162:342-9.

28 

Bojar RA, Eady EA, Jones CE, et al. Inhibition of erythromycin-resistant propionibacteria on the skin of

acne patients by topical erythromycin with and without zinc.  Br J Dermatol 1994;130:329-36.

29 

Borglund E, Hagermark O, Nord CE. Impact of topical clindamycin and systemic tetracycline on the skin

and colon microflora in patients with acne vulgaris.  Scand J Infect Dis Suppl

1984;43(Suppl.):76-81.

30 

Borglund E, Kristensen B, Larsson-Stymne B, et al. Topical meclocycline sulfosalicylate, benzoyl

peroxide, and a combination of the two in the treatment of acne vulgaris.  Acta Derm Venereol

1991;71:175-8.

31/32 

Bottomley WW, Yip J, Knaggs H, et al. Treatment of closed comedones-comparisons of fulguration with

topical tretinoin and electrocautery with fulguration.  Dermatology 1993;186(4):253-7.

33 

Braathen LR. Topical clindamycin versus oral tetracycline and placebo in acne vulgaris.  Scand J Infect

Dis Suppl 1984;43(Suppl.):71-5.

34/35 

Bradford LG, Montes LF. Topical application of vitamin A acid in acne vulgaris.  South Med J

1974;67:683-7.

36 

Brandt H, Attila P, Ahokas T, et al. Erythromycin acistrate - An alternative oral treatment for acne.  J

Dermatol Treat 1994;5:3-5.

37 

Brookes DB, Moffitt RM, Sheil LP, et al. Comparison of Tretinoin and a composite formulation in the

treatment of acne.  Br J Clin Pract 1978;32:349-52.

38 

Bucknall JH, Murdoch PN. Comparison of tretinoin solution and benzoyl peroxide lotion in the treatment

of acne vulgaris.  Curr Med Res Opin 1977;5:266-8.

39 

Burke B, Eady EA, Cunliffe WJ. Benzoyl peroxide versus topical erythromycin in the treatment of acne

vulgaris.  Br J Dermatol 1983;108(2):199-204.

40 

Burton J. A placebo-controlled study to evaluate the efficacy of topical tetracycline and oral tetracycline

in the treatment of mild to moderate acne. Dermatology Research Group.  J Int Med Res

1990;18:94-103.

41 

Cahn MM, Levy EJ. The use of sulfadimethoxine (madribon) in the treatment of papulopustular and

cystic acne vulgaris.  Ann NY Acad Sci 1959;82:84-91.

42/43/44/45/46/47 

Cambazard F. Clinical efficacy of Velac, a new tretinoin and clindamycin phosphate gel in acne vulgaris. 

J Eur Acad Dermatol Venereol 1998;11 Suppl 1:S20-7;discussion S28-9. 

48 

Carlborg L. Cyproterone acetate versus levonorgestrel combined with ethinyl estradiol in the treatment of

acne. Results of a multicenter study.  Acta Obstet Gynecol Scand  1986;Suppl 134:29-32.

49 

Caron D, Sorba V, Kerrouche N, et al. Split-face comparison of adapalene 0.1% gel and tretinoin 0.025%

gel in acne patients.  J Am Acad Dermatol 1997;36:S110-2.

52

Cavicchini S, Caputo R. Long-term treatment of acne with 20% azelaic acid cream.  Acta Derm Venereol

Suppl (Stockh)1989;143:40-4. 

54 

Chalker DK, Lesher JL Jr, Smith JG Jr, et al. Efficacy of topical isotretinoin 0.05% gel in acne vulgaris:

results of a multicenter, double-blind investigation.  J Am Acad Dermatol 1987;17:251-4.

53 

Chalker DK, Shalita A, Smith JG Jr, et al. A double-blind study of the effectiveness of a 3%

erythromycin and 5% benzoyl peroxide combination in the treatment of acne vulgaris.  J Am

Acad Dermatol 1983;9(6):933-6.

55 

Charoenvisal C, Thaipisuttikul Y, Pinjaroen S, et al. Effects on acne of two oral contraceptives

containing desogestrel and cyproterone acetate.  Int J Fertil Menopausal Stud 1996;41:423-9.

56 

Christian GL, Krueger GG. Clindamycin vs placebo as adjunctive therapy in moderately severe acne. 

Arch Dermatol 1975;111:997-1000.

61 

Christiansen J, Gadborg E, Hattel T, et al. The retinoic acid derivative Ro 11-1430 (Tasmaderm) in

patients with acne vulgaris not tolerating retinoic acid. A controlled multicenter trial against

placebo.  Dermatologica 1979;159:466-70.

60 

Christiansen J, Holm P, Reymann F. The retinoic acid derivative Ro 11-1430 in Acne vulgaris. A

controlled multicenter trial against retinoic acid.  Dermatologica 1977;154:219-27.

59 

Christiansen J, Holm P, Reymann F. Treatment of acne vulgaris with the retinoic acid derivative Ro 11-

1430. A controlled clinical trial against retinoic acid.  Dermatologica 1976;153:172-6.

57 

Christiansen JV, Gadborg E, Ludvigsen K, et al. Topical vitamin A acid (Airol) and systemic

oxytetracycline in the treatment of acne vulgaris. A controlled clinical trial.  Dermatologica

1974;149:121-8.

58 

Christiansen JV, Gadborg E, Ludvigsen K, et al. Topical tretinoin, vitamin A acid (Airol) in acne

vulgaris. A controlled clinical trial.  Dermatologica 1974;148:82-9.

62 

Chu A, Huber FJ, Plott RT. The comparative efficacy of benzoyl peroxide 5%/erythromycin 3% gel and

erythromycin 4%/zinc 1.2% solution in the treatment of acne vulgaris.  Br J Dermatol

1997;136:235-8.

63 

Clucas A, Verschoore M, Sorba V, et al. Adapalene 0.1% gel is better tolerated than tretinoin 0.025% gel

in acne patients.  J Am Acad Dermatol 1997;36:S116-8.

64 

Cochran RJ, Tucker SB, Flannigan SA. Topical zinc therapy for acne vulgaris.  Int J Dermatol

1985;24:188-90.

66 

Colver GB, Mortimer PS, Dawber RP. Cyproterone acetate and two doses of oestrogen in female acne; a

double-blind comparison.  Br J Dermatol 1988;118:95-9.

70 

Cornbleet T. Comparison of demethychlortetracycline and tetracycline in acne.  Arch Dermatol

1964;89:144-6.

69 

Cornbleet T. Long-term therapy of acne with tetracycline.  Arch Dermatol 1961;83:414-6.

71 

Crounse RG. The response of acne to placebos and antibiotics.  JAMA 1965;193:906-10.

72 

Cullen SI, Cohan RH. Minocycline therapy in acne vulgaris.  Cutis 1976;17:1208-10, 1214.

75 

Cunliffe WJ, Burke B, Dodman B. Chloramphenicol and benzoyl peroxide in acne. A double-blind

clinical study.  Practitioner 1980;224:952-4.

74 

Cunliffe WJ, Burke B, Dodman B, et al. A double-blind trial of a zinc sulphate/citrate complex and

tetracycline in the treatment of acne vulgaris.  Br J Dermatol 1979;101:321-5.

77 

Cunliffe WJ, Holland KT. Clinical and laboratory studies on treatment with 20% azelaic acid cream for

acne.  Acta Derm Venereol Suppl (Stockh) 1989;143:31-4.

76 

Cunliffe WJ, Holland KT. The effect of benzoyl peroxide on acne.  Acta Derm Venereol 1981;61:267-9.

78/80

Cunliffe W, Caputo R, Dreno B, et al. Clinical efficacy and safety comparison of adapalene gel and

tretinoin gel in the treatment of acne vulgaris: Europe and U.S. multicenter trials.  J Am Acad

Dermatol 1997;36:S126-34.

82 

Danto JL, Maddin WS, Stewart WD, et al. A controlled trial of benzoyl peroxide and precipitated sulfur

cream in acne vulgaris.  Appl Ther 1966;8:624-5.

84

De Bersaques J. Topical vitamin A acid. Review of the literature and results of a clinical trial in acne. 

Arch Belg Dermatol Syphiligr 1972;28(4):315-34.

85 

Degreef H, Vanden BG. Double-blind evaluation of miconazole-benzoyl peroxide combination for the

topical treatment of acne vulgaris.  Dermatologica 1982;164:201-208.

86 

Delaney J, Ferrara RJ, Robarge I.   Treatment of acne vulgaris with polythionates incorporated in a

vanishing cream.  J Mich Med Soc 1959;58:1259-61.

87 

Dieben TO, Vromans L, Theeuwes A, et al. The effects of CTR-24, a biphasic oral contraceptive

combination, compared to Diane-35 in women with acne.  Contraception 1994;50:373-82.

89 

Dobson RL, Belknap BS. Topical erythromycin solution in acne. Results of a multiclinic trial.  J Am

Acad Dermatol 1980;3(5):478-82.

90 

Dominguez J, Hojyo MT, Celayo JL, et al. Topical isotretinoin vs. topical retinoic acid in the treatment

of acne vulgaris.  Int J Dermatol 1998;37(1):54-5.

91 

Dreno B, Amblard P, Agache P, et al. Low doses of zinc gluconate for inflammatory acne.  Acta Derm

Venereol 1989;69:541-3.

93 

Dunlap FE, Baker MD, Plott RT, et al. Adapalene 0.1% gel has low skin irritation potential even when

applied immediately after washing.  Br J Dermatol 1998;139 Suppl 52:23-5. 

92 

Dunlap FE, Mills OH, Tuley MR, et al. Adapalene 0.1% gel for the treatment of acne vulgaris: its

superiority compared to tretinoin 0.025% cream in skin tolerance and patient preference.  Br J

Dermatol 1998;139 Suppl 52:17-22. 

94 

Dunlop KJ, Barnetson RS. A comparative study of isolutrol versus benzoyl peroxide in the treatment of

acne.  Australas J Dermatol 1995;36:13-5.

95 

Eady EA, Burke BM, Pulling K, et al. The benefit of 2% salicylic acid lotion in acne - A placebo-

controlled study.  J Dermatol Treat 1996;7:93-96.

97 

Ede M. A double-blind, comparative study of benzoyl peroxide, benzoyl peroxide-

chlorhydroxyquinoline, benzoyl peroxide-chlorhydroxyquinoline-hydrocortisone, and placebo

lotions in acne.  Curr Ther Res Clin Exp 1973;15:624-9.

98 

Elbaum DJ. Comparison of the stability of topical isotretinoin and topical tretinoin and their efficacy in

acne.  J Am Acad Dermatol 1988;19:486-91.

99 

Ellis CN, Gammon WR, Stone DZ, et al. A comparison of Cleocin T Solution, Cleocin T Gel, and

placebo in the treatment of acne vulgaris.  Cutis 1988;42:245-7.

100 

Ellis CN, Millikan LE, Smith EB, et al. Comparison of adapalene 0.1% solution and tretinoin 0.025% gel

in the topical treatment of acne vulgaris.  Br J Dermatol 1998;139 Suppl 52:41-7. 

101 

Elstein W. Topical deodorized polysulfides. Broadscope acne therapy.  Cutis 1981;28:468-72.

102 

Ereaux LP. A new lotion for the treatment of acne vulgaris.  Can Med Assoc J 1965;92:157-9.

103 

Erkkola R, Hirvonen E, Luikku J, et al. Ovulation inhibitors containing cyproterone acetate or

desogestrel in the treatment of hyperandrogenic symptoms.  Acta Obstet Gynecol Scand

1990;69:61-5.

106 

Farrell LN, Strauss JS, Stranieri AM. The treatment of severe cystic acne with 13-cis-retinoic acid.

Evaluation of sebum production and the clinical response in a multiple dose trial.  J Am Acad

Dermatol 1980;3(6):602-11.

108 

Feucht CL, Allen BS, Chalker DK, et al. Topical erythromycin with zinc in acne. A double-blind

controlled study.  J Am Acad Dermatol 1980;3(5):483-91.

109 

Flanders PA, McNamara JR. Enhancing acne medication compliance: a comparison of strategies.  Behav

Res Ther 1985;23(2):225-7.

110 

Flinn JH. The treatment of acne with tolbutamide.  Student Med 1961;9:234-7.

111 

Fluckiger R, Furrer HJ, Rufli T. Efficacy and tolerance of a miconazole-benzoyl peroxide cream

combination versus a benzoyl peroxide gel in the topical treatment of acne vulgaris. 

Dermatologica 1988;177:109-14.

114 

Franz E, Weidner-Strahl S. The effectiveness of topical antibacterials in acne: a double-blind clinical

study.  J Int Med Res 1978;6:72-7.

115 

Fraser NB, Main RA, Stewart TW, et al. Treatment of acne vulgaris comparing two similar lotion

formulations, one with ('Actinac') and one without chloramphenicol.  Curr Med Res Opin

1980;6:461-5.

117 

Fugere P, Percival-Smith RK, Lussier-Cacan S, et al. Cyproterone acetate/ethinyl estradiol in the

treatment of acne. A comparative dose-response study of the estrogen component.  Contraception

1990;42:225-34.

118 

Fyrand O, Jakobsen HB. Water-based versus alcohol-based benzoyl peroxide preparations in the

treatment of acne vulgaris.  Dermatologica 1986;172:263-7.

119/120 

Galvin SA, Gilbert R, Baker M, et al. Comparative tolerance of adapalene 0.1% gel and six different

tretinoin formulations.  Br J Dermatol 1998;139 Suppl 52:34-40. 

121/122/123

Gamborg-Nielsen P. Topical metronidazole gel. Use in acne vulgaris.  Int J Dermatol 1991;30:662-6.

125 

Gammon WR, Meyer C, Lantis S, et al. Comparative efficacy of oral erythromycin versus oral

tetracycline in the treatment of acne vulgaris. A double-blind study.  J Am Acad Dermatol

1986;14:183-6.

126 

Gandola M, Argenziano G, Barba C, et al. Topical vitamin A acid in the treatment of acne vulgaris (a

controlled multicenter trial).  Arch Dermatol Res 1976;255:129-38.

127 

Geiger JM, Hommel L, Harms M, et al. Oral 13-cis retinoic acid is superior to 9-cis retinoic acid in

sebosuppression in human beings.  J Am Acad Dermatol 1996;34:513-5.

128 

Gibson JR, Darley CR, Harvey SG, et al. Oral trimethoprim versus oxytetracycline in the treatment of

inflammatory acne vulgaris.  Br J Dermatol 1982;107:221-224.

130 

Goldstein JA, Socha-Szott A, Thomsen RJ, et al. Comparative effect of isotretinoin and etretinate on

acne and sebaceous gland secretion.  J Am Acad Dermatol 1982;6(4 Pt 2 Suppl):760-5.

131 

Goltz RW, Coryell GM, Schnieders JR, et al. A comparison of Cleocin T 1 percent solution and Cleocin

T 1 percent lotion in the treatment of acne vulgaris.  Cutis 1985;36:265-8.

132 

Goodfellow A, Alaghband-Zadeh J, Carter G, et al. Oral spironolactone improves acne vulgaris and

reduces sebum excretion.  Br J Dermatol 1984;111:209-214.

133 

Goransson K, Liden S, Odsell L. Oral zinc in acne vulgaris: a clinical and methodological study.  Acta

Derm Venereol 1978;58:443-8.

136 

Gratton D, Raymond GP, Guertin-Larochelle S, et al. Topical clindamycin versus systemic tetracycline in

the treatment of acne. Results of a multiclinic trial.  J Am Acad Dermatol 1982;7(1):50-3.

137 

Greenwood R, Brummitt L, Burke B, et al. Acne: double blind clinical and laboratory trial of

tetracycline, oestrogen-cyproterone acetate, and combined treatment.  Br Med J Clin Res Ed

1985;291:1231-5.

138/139 

Groot WP de, Prakken J, Verbeek A, et al. The value of grenz-ray therapy for acne vulgaris. 

Dermatologica 1963;126:319-25.

140 

Grosshans E, Marks R, Mascaro JM, et al. Evaluation of clinical efficacy and safety of adapalene 0.1%

gel versus tretinoin 0.025% gel in the treatment of acne vulgaris, with particular reference to the

onset of action and impact on quality of life.  Br J Dermatol 1998;139 Suppl 52:26-33. 

141 

Gruber DM, Sator MO, Joura EA, et al. Topical cyproterone acetate treatment in women with acne: a

placebo-controlled trial.  Arch Dermatol 1998;134(4):459-63.

142 

Guerrier CJ, Thornton EJ. Double-blind comparison of two similar lotion formulations, one without and

the other with hydrocortisone acetate ('Actinac') in the treatment of acne vulgaris.  Curr Med Res

Opin 1980;6:377-9.

144 

Guin JD. Treatment of acne vulgaris with topical clindamycin phosphate: a double-blind study.  Int J

Dermatol 1981;20(4):286-8.

143 

Guin JD. Topical clindamycin: a double-blind study comparing clindamycin phosphate with clindamycin

hydrochloride.  Int J Dermatol 1979;18:164-6.

145/146 

Gunning DB, Barua AB, Lloyd RA, et al. Retinoyl beta-glucuronide: A nontoxic retinoid for the topical

treatment of acne.  J Dermatol Treat 1994;5:181-185.

147 

Habbema L, Koopmans B, Menke HE, et al. A 4% erythromycin and zinc combination (Zineryt) versus

2% erythromycin (Eryderm) in acne vulgaris: a randomized, double-blind comparative study.  Br

J Dermatol 1989;121:497-502.

149 

Handojo I. The combined use of topical benzoyl peroxide and tretinoin in the treatment of acne vulgaris. 

Int J Dermatol 1979;18(6):489-96.

151 

Hansted B, Jorgensen J, Reymann F, et al. Fucidin(Reg.trademark) cream for topical treatment of acne

vulgaris.  Curr Ther Res  1985;37:249-253.

152 

Harcup JW, Cooper J. The treatment of acne vulgaris in general practice. A double-blind assessment of

co-trimoxazole and tetracycline.  Practitioner 1980;224:747-50.

155 

Harrison PV. A comparison of doxycycline and minocycline in the treatment of acne vulgaris.  Clin Exp

Dermatol 1988;13(4):242-4.

156 

Hatwal A, Bhatt RP, Agrawal JK, et al. Spironolactone and cimetidine in treatment of acne.  Acta Derm

Venereol 1988;68:84-7.

157 

Hellgren L, Vincent J. Topical erythromycin for acne vulgaris.  Dermatologica 1980;161(6):409-14.

158 

Henderson TA, Olson WH, Leach AD. A single-blind, randomized comparison of erythromycin pledgets

and clindamycin lotion in the treatment of mild to moderate facial acne vulgaris.  Adv Ther

1995;12:172-177.

160 

Hersle K. Trimethoprim-sulphamethoxazole in acne vulgaris. A double-blind study.  Dermatologica

1972;145:187-91.

161 

Hersle K, Gisslen H. Minocycline in acne vulgaris: a double-blind study.  Curr Ther Res Clin Exp

1976;19:339-42.

162 

Hicks JH. Demethylchloretracycline: a double-blind study in the treatment of acne with attention to side-

effects noted.  South Med J 1962;55:357-60.

163 

Hillstrom L, Pettersson L, Hellbe L, et al. Comparison of oral treatment with zinc sulphate and placebo in

acne vulgaris.  Br J Dermatol 1977;97:679-84.

166/167 

Hjorth N, Graupe K. Azelaic acid for the treatment of acne. A clinical comparison with oral tetracycline. 

Acta Derm Venereol Suppl(Stockh) 1989;143:45-8.

164 

Hjorth N, Schmidt H, Thomsen K, et al. Meclosorb, a new topical antibiotic agent in the treatment of

acne vulgaris: a double-blind clinical study.  Acta Derm Venereol 1984;64:354-7.

165 

Hjorth N, Storm D, Dela K. Topical anhydrous aluminum chloride formulation in the treatment of acne

vulgaris: a double-blind study.  Cutis 1985;35:499-500.

171 

Hubbell CG, Hobbs ER, Rist T, et al. Efficacy of minocycline compared with tetracycline in treatment of

acne vulgaris.  Arch Dermatol 1982;118(12):989-92.

173 

Hughes BR, Norris JF, Cunliffe WJ. A double-blind evaluation of topical isotretinoin 0.05%, benzoyl

peroxide gel 5% and placebo in patients with acne.  Clin Exp Dermatol 1992;17:165-8.

172 

Hughes H, Brown BW, Lawlis GF, et al. Treatment of acne vulgaris by biofeedback relaxation and

cognitive imagery.  J Psychosom Res 1983;27:185-91.

175 

Hull SM, Cunliffe WJ. The use of a corticosteroid cream for immediate reduction in the clinical signs of

acne vulgaris.  Acta Derm Venereol 1989;69:452-3.

176 

Hunt MJ, Barnetson RS. A comparative study of gluconolactone versus benzoyl peroxide in the treatment

of acne.  Australas J Dermatol 1992;33:131-4.

177 

Jaffe GV, Grimshaw JJ, Constad D. Benzoyl peroxide in the treatment of acne vulgaris: a double-blind,

multi-centre comparative study of 'Quinoderm' cream and 'Quinoderm' cream with hydrocortisone versus their base vehicle alone and a benzoyl peroxide only gel preparation.  Curr

Med Res Opin 1989;11:453-62.

178 

Jelinek JE. Hydrochlorothiazide and the control of premenstrual exacerbation of acne.  Arch Dermatol

1972;105:79-80.

179/180 

Jelliffe AM, Soutter C, Meara RH. An investigation into the treatment of acne vulgaris with Grenz x-

rays.  Br J Dermatol 1969;81:617-20.

185 

Jones DH, King K, Miller AJ, et al. A dose-response study of I3-cis-retinoic acid in acne vulgaris.  Br J

Dermatol 1983;108:333-43.

184 

Jones EL, Crumley AF. Topical erythromycin vs blank vehicle in a multiclinic acne study.  Arch

Dermatol 1981;117:551-3.

187/188 

Katsambas A, Graupe K, Stratigos J. Clinical studies of 20% azelaic acid cream in the treatment of acne

vulgaris. Comparison with vehicle and topical tretinoin.  Acta Derm Venereol Suppl (Stockh)

1989;143:35-9.

186 

Katsambas A, Towarky AA, Stratigos J. Topical clindamycin phosphate compared with oral tetracycline

in the treatment of acne vulgaris.  Br J Dermatol 1987;116:387-91.

189 

Kern AB. Gamma-globulin in treatment of acne and psoriasis.  Arch Dermatol 1962;85:623-4.

190 

King K, Jones DH, Daltrey DC, et al. A double-blind study of the effects of 13-cis-retinoic acid on acne,

sebum excretion rate and microbial population.  Br J Dermatol 1982;107(5):583-90.

191 

Kirton V. Evaluation of new preparation for the treatment of acne vulgaris.  Br J Clin Pract 1967;21:127-

8.

192/193 

Knox JM, Owens DW. Demthethylchloretetracycline in the treatment of acne vulgaris.  South Med J

1965;58:1056. 

194/195 

Knutson DD, Swinyer LJ, Smoot WH. Meclocycline sulfosalicylate. Topical antibiotic agent for the

treatment of acne vulgaris.  Cutis 1981;27(2):203-4, 208-10.

197 

Korting HC, Ponce Poschl E, Klovekorn W, et al. The influence of the regular use of a soap or an acidic

syndet bar on pre-acne.  Infection 1995;23:89-93.

198 

Krishnan G. Comparison of two concentrations of tretinoin solution in the topical treatment of acne

vulgaris.  Practitioner 1976;216:106-9.

199 

Kuhlman DS, Callen JP. A comparison of clindamycin phosphate 1 percent topical lotion and placebo in

the treatment of acne vulgaris.  Cutis 1986;38:203-6.

201 

Lane P, Williamson DM. Treatment of acne vulgaris with tetracycline hydrochloride: a double-blind trial

with 51 patients.  Br Med J 1969;2:76-9.

202 

Langner A, Boorman GC, Stapor V, et al. Isotretinoin cream 0.05% and 0.1% in the treatment of acne

vulgaris.  J Dermatol Treat 1994;5:177-180.

204 

Lassus A. The effect of silicol gel compared with placebo on papulopustular acne and sebum production.

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205 

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