Evidence Table E1. Articles/arms for class RETINOID (TOPICAL).

CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

E.01.01 78 Adapalene 0.3 % topical qhs. Adapalene 0.1 % topical qhs. Continuous

Waited 20-30 min after 

washing to apply gel. 

Cetaphil® gentle 

cleaning bar.

92 Adapalene 5 mg topical qd. Adapalene 5 mg topical qd. Continuous

Synthetic naphthoic acid 

derivative. 

Synthetic naphthoic 

acid derivative. 

338 Continuous

Discrete

Adapalene 0.03 % topical qhs. Adapalene 0.1 % topical qhs. 

E.01.02 49 Adapalene 0.1 % topical qhs. To dry skin. Tretinoin 0.025 % topical qhs. To dry skin. Discrete

Normal washing and 

moisturizer, if required.

Normal washing and 

moisturizer, if required.

63 Adapalene 0.1 % topical qhs. Tretinoin 0.025 % topical qhs. Discrete

1 hour before bedtime 

for 12 weeks. 

78 Adapalene 0.1 % topical qhs. Tretinoin 0.025 % topical qhs. Continuous

1 hour before bedtime 

for 12 weeks. 

Adapalene 0.3 % topical qhs. Tretinoin 0.025 % topical qhs. Continuous

80 Continuous

Discrete

Adapalene 0.1 % topical qhs. Tretinoin 0.025 % topical qhs. 

93 Continuous

Discrete

Adapalene 0.1 % topical qd. Tretinoin 0.025 % topical qd. 

100 Continuous

Discrete

Adapalene 0.1 % topical qhs. Tretinoin 0.025 % topical qhs. 

Under a nonporous 

adhesive bandage, applied 

to back at the same site 

each day (patch test). 

119 Same. Continuous

Discrete

Adapalene 0.1 % topical qd. Tretinoin 0.1 % topical qd. (M)

Under a nonporous 

adhesive bandage, applied 

to back at the same site 

each day (patch test). 

120 Same. Continuous

Discrete

Adapalene 0.1 % topical qd. Tretinoin 0.1 % topical qd. (M)

Apply thin layer 15 min 

after washing and one hour 

before bed. 

Apply thin layer 15 min 

after washing and one 

hour before bedtime; 

purchased 

commercially and 

relabeled. 

140 Continuous

Discrete

Adapalene 0.1 % topical qhs. Tretinoin 0.025 % topical qhs. 

306 Continuous

Discrete

Adapalene 0.01 % topical qhs. Tretinoin 0.025 % topical qhs. 

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table E HEADING: Page 1 of 5
CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

Synthetic naphthoic acid 

derivative. 

E.01.02 338 Continuous

Discrete

Adapalene 0.1 % topical qhs. Tretinoin 0.25 % topical qhs. 

Synthetic naphthoic acid 

derivative. 

Continuous

Discrete

Adapalene 0.03 % topical qhs. Tretinoin 0.25 % topical qhs. 

E.02.01 54 Continuous

Discrete

Isotretinoin 0.05 % topical bid. Vehicle No dose information. 

173 Continuous

Discrete

Isotretinoin 0.05 % topical bid. Vehicle No dose information. 

202 Continuous

Discrete

Isotretinoin 0.1 % topical bid. Vehicle No dose information. 

Continuous

Discrete

Isotretinoin 0.5 % topical bid. Vehicle No dose information. 

E.02.02 173 Continuous

Discrete

Isotretinoin 0.05 % topical bid. Benzoyl 5 % topical bid. 

peroxide

E.02.03 202 Continuous

Discrete

Isotretinoin 0.5 % topical bid. Isotretinoin 0.1 % topical bid. 

E.02.04 90 Continuous

Discrete

Isotretinoin 0.05 % topical qhs. Tretinoin 0.05 % topical qhs. 

Began qhs and advanced to 

bid. Mild soap, avoid 

irritants, use sunblock.

Began qhs and 

advanced to bid. Mild 

soap, avoid irritants, 

use sunblock.

98 Continuous

Discrete

Isotretinoin 0.05 % topical bid. Tretinoin 0.05 % topical bid. 

E.03.01 60 Motretinide 0.1 % topical bid. Vehicle No dose information. Discrete

61 Continuous

Discrete

Motretinide 0.1 % topical bid. Vehicle No dose information. 

E.03.02 253 Continuous

Discrete

Motretinide 0.1 % topical bid. Motretinide 0.1 % topical qd. 

E.03.03 59 Continuous

Discrete

Motretinide 0.1 % topical bid. Tretinoin 0.05 % topical bid. 

60 Motretinide 0.1 % topical bid. Tretinoin 0.05 % topical bid. Discrete

253 Continuous

Discrete

Motretinide 0.1 % topical bid. Tretinoin 0.05 % topical qd. 

Motretinide 0.1 % topical qd. Tretinoin 0.05 % topical qd. Continuous

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table E HEADING: Page 2 of 5
CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

Discrete

Water soluble endogenous 

metabolite of vitamin A. 

Pre-Sun® 29 sunscreen.

E.04.01 145 Pre-Sun® 29 sunscreen. Continuous

Discrete

Retinyl beta- 1.2 % topical bid. 

glucuronide

Vehicle No dose information. 

0.16% for 10 weeks, 0.24% 

for 12 weeks, then 0.32% 

for 4 weeks. Pre-Sun® 29 

sunscreen.

E.04.02 146 Pre-Sun® 29 sunscreen. Continuous

Discrete

Retinyl beta- 0.24 % topical qd. 

glucuronide

Tretinoin 0.1 % topical qd. 

Frequency varied if 

irritated. 

E.05.01 58 Continuous

Discrete

Tretinoin 0.02 % topical bid. Vehicle No dose information. 

Continuous

Discrete

Tretinoin 0.05 % topical bid. Vehicle No dose information. 

60 Tretinoin 0.05 % topical bid. Vehicle No dose information. Discrete

119 Same. Same. Continuous

Discrete

Tretinoin 0.05 % topical qd. Petrolatum No dose information. (M)

120 Same. Same. Continuous

Discrete

Tretinoin 0.025 % topical qd. Petrolatum No dose information. (M)

Qd or bid x 6 weeks then 

reduced to alternate days 

as tolerated; 0.7cc per 

swab. 

Qd or bid then reduced 

to alternate days, as 

tolerated. 

198 Continuous

Discrete

Tretinoin 0.025 % topical qd. Vehicle 0.7 cc topical qd. 

Qd or bid x 6 weeks then 

reduced to alternate days 

as tolerated; 0.7cc per 

swab. 

Qd or bid then reduced 

to alternate days, as 

tolerated. 

Continuous

Discrete

Tretinoin 0.05 % topical qd. Vehicle 0.7 cc topical qd. 

1/2 inch ribbon. Purpose® 

soap.

219 Purpose® soap. Continuous

Discrete

Tretinoin 0.025 % topical qhs. Polyoprepolyme 0.5 inch topical qhs. 

r-2

1/2 inch ribbon. Purpose® 

soap.

Purpose® soap. Continuous

Discrete

Polyoprepolyme No dose information. 

r-2

Tretinoin 0.025 % topical qhs. 

Polyoprepolyme 0.5 inch topical qhs. 

r-2

Purpose® soap; 

Durascreen® sunscreen, if 

needed.

Purpose® soap; 

Durascreen® 

sunscreen, if needed.

220 Continuous

Discrete

Tretinoin 0.025 % topical qhs. Vehicle No dose information. 

Purpose® soap; 

Durascreen® sunscreen, if 

needed.

Purpose® soap; 

Durascreen® 

sunscreen, if needed.

Continuous

Discrete

Tretinoin 0.025 % topical qhs. Vehicle No dose information. 

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table E HEADING: Page 3 of 5
CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

E.05.01 270 Tretinoin 0.05 % topical bid. Vehicle No dose information. Discrete

Vehicle ethanol+alphatoapherolqq. 

E.05.015 84 Tretinoin 0.05 % topical qd. Sulphur No dose information. Discrete

Resorcinol 3 % topical qd. 

Salicylic acid 3 % topical qd. 

E.05.02 38 Continuous

Discrete

Tretinoin 0.025 % topical bid. Benzoyl 5 % topical bid. 

peroxide

149 Vehicle alcohol. Continuous

Discrete

Tretinoin 0.05 % topical bid. Benzoyl 10 % topical bid. (M)

peroxide

At least once a day then as 

needed; may be 

discontinued for few days it 

irritation. 

221 Continuous

Discrete

Tretinoin 0.1 % topical qd. Benzoyl 5 % topical qd. 

peroxide

At least once a day then as 

needed; may be 

discontinued for few days it 

irritation. 

4 weeks 5%; 4 weeks 

10%; once or 

twice/day. 

Continuous

Discrete

Tretinoin 0.1 % topical qd. Benzoyl 5 % topical qd. 

peroxide

Frequency was qd for 

first 2 weeks. 

E.05.04 188 Continuous

Discrete

Tretinoin 0.05 % topical bid. Azelaic acid 20 % topical bid. 

Glycolic acid 15% for 

first month; glycolic 

acid at evening. 

316 Continuous

Discrete

Vehicle No dose information. 

Tretinoin 0.025 % topical qd. 

Glycolic acid 20 % topical qhs. 

Azelaic acid 20 % topical bid. 

Frequency varied if 

irritated. 

E.05.07 58 Continuous

Discrete

Tretinoin 0.02 % topical bid. Tretinoin 0.05 % topical bid. 

Vehicle ethanol+alphatoapherolqq. 

84 Tretinoin 0.05 % topical qd. Sulphur No dose information. Discrete

Resorcinol 3 % topical qd. 

Salicylic acid 3 % topical qd. 

119 Same. Same. Continuous

Discrete

Tretinoin 0.025 % topical qd. Tretinoin 0.01 % topical qd. (M)

120 Same. Same. Continuous

Discrete

Tretinoin 0.025 % topical qd. Tretinoin 0.1 % topical qd. (M)

Qd or bid x 6 weeks then 

reduced to alternate days 

as tolerated; 0.7cc per 

swab. 

Qd or bid x 6 weeks 

then reduced to 

alternate days as 

tolerated; 0.7cc per 

swab. 

198 Continuous

Discrete

Tretinoin 0.025 % topical qd. Tretinoin 0.05 % topical qd. 

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table E HEADING: Page 4 of 5
CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

1/2 inch ribbon. Purpose® 

soap.

1/2 inch ribbon. 

Purpose® soap.

E.05.07 219 Continuous

Discrete

Polyoprepolyme No dose information. 

r-2

Tretinoin 0.025 % topical qhs. 

Tretinoin 0.025 % topical qhs. 

Purpose® soap; 

Durascreen® sunscreen, if 

needed.

Purpose® soap; 

Durascreen® 

sunscreen, if needed.

220 Continuous

Discrete

Tretinoin 0.025 % topical qhs. Tretinoin 0.025 % topical qhs. 

Or tretinoin 0.05% ; 

combined results for 

acne outcomes. 

302 Continuous

Discrete

Tretinoin 0.05 % topical qhs. Tretinoin 0.025 % topical qhs. (M)

Frequency was qd for fair, 

sensitive skin or for 

erythema equivalent to a 

mild sunburn. 

Frequency was qd for 

fair, sensitive skin or 

for erythema equivalent 

to a mild sunburn. 

E.05.08 13 Continuous

Discrete

Tretinoin 0.025 % topical bid. Neomycin No dose information. 

Methylpredniso No dose information. 

lone

E.05.09 37 Mild soap. Mild soap. Continuous

Discrete

Tretinoin 0.025 % topical bid. Hydrocortisone 10 % topical bid. 

Chloramphenic 10 % topical bid. 

ol

E.06.01 34 Vitamin A 0.05 % topical bid. Vehicle No dose information. Discrete

35 Continuous

Discrete

Vitamin A 0.05 % topical bid. Vehicle No dose information. 

E.06.02 272 0.1 % topical (can't Continuous

say)

Vitamin A 3 % topical (can't 

say)

Resorcinol

5 % topical (can't 

say)

Sulphur

First week 2x1 day; 2-7 

weeks 1x1 day. 

E.06.03 57 Vitamin A 0.05 % topical qd. Discrete

Placebo No dose information. 

Oxytetracycline 250 mg oral qd. 

Vehicle No dose information. 

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table E HEADING: Page 5 of 5