Evidence Table C1. Articles/arms for class ANTI-BACTERIAL (TOPICAL).

CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

Non-medicated soap and 

shampoo.

pH adjusted to 6.7. 

Non-medicated soap 

and shampoo.

C.01.01 20 Continuous

Discrete

Clindamycin 1 % topical bid. 

phosphate

Vehicle No dose information. 

Non-medicated soap and 

shampoo.

pH adjusted to 6.7. 

Non-medicated soap 

and shampoo.

Continuous

Discrete

Clindamycin 1 % topical bid. 

hydrochloride

Vehicle No dose information. 

33 Clindamycin pH adjusted. Continuous

Discrete

Vehicle No dose information. 

Clindamycin No dose information. 

Vehicle No dose information. 

Vehicle No dose information. 

Purpose® soap before 

applying placebo.

99 Clindamycin 1 % topical bid. Continuous

phosphate

Placebo No dose information. 

Purpose® soap before 

applying placebo.

Clindamycin 1 % topical bid. Continuous

phosphate

Placebo No dose information. 

Vehicle water. Active 

treatment including oval 

anti-bacterial and retinoic 

acid. .

Active treatment, 

including oral antibacterial and retinoic 

acid..

144 Clindamycin 1 % topical bid. Discrete

phosphate

Vehicle No dose information. 

Purpose® soap (bar). Dose given on per one 

week basis. Purpose® 

soap (bar).

199 Continuous

Discrete

Clindamycin 1 % topical bid. 

phosphate

Vehicle 4.3 g topical bid. 

217 Clindamycin No dose information. Vehicle No dose information. Continuous

327 Continuous

Discrete

Clindamycin No dose information. 

hydrochloride

Vehicle No dose information. 

Ivory® soap; Suave® 

shampoo.

Ivory® soap; Suave® 

shampoo.

C.01.02 305 Continuous

Discrete

Clindamycin 1 % topical bid. Nicotinamide 4 % topical bid. 

Non-medicated soap and 

shampoo.

Non-medicated soap 

and shampoo.

C.01.03 20 Continuous

Discrete

Clindamycin 1 % topical bid. 

phosphate

Clindamycin 1 % topical bid. 

hydrochloride

Non-medicated soap and 

shampoo.

Non-medicated soap 

and shampoo.

Continuous

Discrete

Clindamycin 1 % topical bid. 

hydrochloride

Clindamycin 1 % topical bid. 

phosphate

99 Clindamycin 1 % topical bid. Continuous

phosphate

Clindamycin 1 % topical bid. 

phosphate

Clindamycin 1 % topical bid. Continuous

phosphate

Clindamycin 1 % topical bid. 

phosphate

131 Purpose® soap. Purpose® soap. Continuous

Discrete

Clindamycin 1 % topical bid. Clindamycin 1 % topical bid. 

Clindamycin 1 % topical bid. Purpose® soap. Clindamycin 1 % topical bid. Purpose® soap. Continuous

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table C HEADING: Page 1 of 5
CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

Discrete

143 1 % topical (can't Continuous

say)

Clindamycin 

hydrochloride

1 % topical (can't 

say)

Clindamycin 

phosphate

1 % topical (can't Continuous

say)

Clindamycin 

phosphate

1 % topical (can't 

say)

Clindamycin 

hydrochloride

Wash with sulfatic 

sulfactoral soap (Acne 

Aid®), apply hot facial 

pack with washcloth, then 

apply formulation.

Wash with sulfatic 

sulfactoral soap (Acne 

Aid®), apply hot facial 

pack with washcloth, 

then apply formulation.

229 Clindamycin 2 % topical bid. Continuous (M)

hydrochloride

Clindamycin 2 % topical bid. 

phosphate

267 Purpose® soap. Purpose® soap. Continuous

Discrete

Clindamycin 1 % topical bid. Clindamycin 1 % topical bid. 

Purpose® soap. Purpose® soap. Continuous

Discrete

Clindamycin 1 % topical bid. Clindamycin 1 % topical bid. 

Patients were instructed to 

wash face with Purpose® 

soap pat the area dry with 

a towel, and wait 20 

minutes before applying 

the study medication. 

Purpose® soap.

C.01.04 158 Continuous

Discrete

Clindamycin 1 % topical bid. 

phosphate

Erythromycin 2 % topical bid. 

208 Continuous

Discrete

Clindamycin 1 topical bid. 

phosphate

Erythromycin 2 topical bid. 

Morning and bedtime. 

Purpose® soap.

Morning and bedtime. 

Purpose® soap.

244 Continuous

Discrete

Clindamycin 1 % topical bid. Erythromycin 2 % topical bid. 

303 Alpha Keri®-soap. Alpha Keri®-soap. Continuous

Discrete

Clindamycin 1 % topical bid. Erythromycin 1.5 % topical bid. 

If side effect present, 

treatment changed to once 

a day. Alpha Keri®-mild 

soap.

If side effect present 

then treatment was 

once a day. Alpha 

Keri®-mild soap.

326 Continuous

Discrete

Clindamycin 1.5 % topical bid. Erythromycin 1.5 % topical bid. 

If side effect present, 

treatment changed to once 

a day. Alpha Keri®-mild 

soap.

If side effect present 

then treatment was 

once a day. Alpha 

Keri®-mild soap.

Continuous

Discrete

Clindamycin 1.5 % topical bid. Erythromycin 1.5 % topical bid. 

Acne Aid® soap, 

Johnson®'s baby shampoo.

C.01.05 261 Continuous

Discrete

Clindamycin 1 % topical bid. Tetracycline No dose information. 

hydrochloride

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table C HEADING: Page 2 of 5
CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

C.01.05 291 Applied after washing. Applied after washing. Continuous

Discrete

Clindamycin 1 % topical bid. Tetracycline No dose information. 

Cetaphil® lotion - nonmedicated lipid free 

cleanser bid.

Cetaphil® lotion - nonmedicated lipid free 

cleanser bid.

C.01.06 324 Clindamycin 1 % topical bid. Continuous

phosphate

Benzoyl 5 % topical bid. 

peroxide

329 clindamycin 1 % topical bid. Continuous

phosphate

Benzoyl 5 5 topical bid. 

Peroxide

C.02.03 214 Continuous

Discrete

Benzoyl 5 % topical qhs. (M)

peroxide

Clindamycin 1 % topical qhs. 

Benzoyl 5 % topical qhs. 

peroxide

BP in am; CP in evening. 

Non-medicated mild soap..

329 Benzoyl 5 % topical qd. Continuous

Peroxide

Clindamycin 1 % topical qd. 

phosphate

Benzoyl 5 5 topical bid. 

Peroxide

Vehicle propylene glycol 

laureth. 

Vehicle propylene 

glycol laureth. 

C.03.01 39 Continuous

Discrete

Erythromycin 1.5 % topical bid. Erythromycin No dose information. 

base

89 Vehicle Laureth. Vehicle Laureth -4. Continuous

Discrete

Erythromycin 1.5 % topical bid. Placebo No dose information. 

157 Vehicle. Vehicle. Continuous

Discrete

Erythromycin 1 % topical bid. Vehicle No dose information. 

Culic acid .047, 20% 

preparation, 170 

micogram/sq cm. Nonmedicated soap and 

shampoo.

Non-medicated soap 

and shampoo.

184 Continuous

Discrete

Erythromycin 1.5 ml topical bid. Vehicle 1.5 ml topical bid. 

Applied medication under 

supervision at initial visit. 

Applied medication 

under supervision at 

initial visit. 

205 Continuous

Discrete

Erythromycin 2 % topical bid. Vehicle No dose information. 

274 Erythromycin 2 % topical bid. Non-medicated soap . Vehicle No dose information. Non-medicated soap. Continuous

Vehicle's brand name is 

Neutrogena Vehicle/N. 

Neutrogena® Unscented 

soap.

Neutrogena® 

Unscented soap.

277 Continuous

Discrete

Erythromycin 2 % topical bid. Vehicle No dose information. 

285 Continuous

Discrete

Erythromycin 1.5 % topical bid. Vehicle No dose information. 

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table C HEADING: Page 3 of 5
CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

Vehicle propylene glycol 

laureth. 

C.03.025 39 Continuous

Discrete

Erythromycin 1.5 % topical bid. Benzoyl 5 % topical bid. 

Peroxide

C.04.01 151 Continuous

Discrete

2 % topical (can't 

say)

Fusidin Vehicle No dose information. 

315 Fusidin 2 % topical bid. Placebo No dose information. Continuous

Mild soap & shampoo 

supplied..

Vehicle cream. 

Meoclocycline vehicle. 

Mild soap & shampoo 

supplied/.

C.05.005 194 Continuous

Discrete

Meclocycline 1 % topical bid. 

sulfosalicylate

Vehicle No dose information. 

195 Continuous

Discrete

Meclocycline 1 % topical qd. 

sulfosalicylate

Placebo No dose information. 

A.M. Only for first week; 

wash off after 3 hrs. For 

first 3 weeks. 

A.M. Only for first 

week; wash off after 3 

hrs for for first 3 weeks. 

C.05.01 30 Continuous

Discrete

Meclocycline 1 % topical bid. Benzoyl 5 % topical bid. 

peroxide

C.06.01 328 Continuous

Discrete

0.75 % topical (can't 

say)

Metronidazole Placebo No dose information. 

C.07.01 287 Neomycin 0.5 % topical bid. Sulphur 2.7 % topical bid. Bland soap. Discrete (M)

Hydrocortisone 0.5 % topical bid. 

F

Resorcinol 1.5 % topical bid. 

Neomycin 0.5 % topical bid. 

C.08.01 10 Continuous

Discrete

Placebo 250 mg oral bid. 

Tetracycline 0.5 % topical bid. 

Placebo 250 mg oral bid. 

Vehicle No dose information. 

Non-antibacterial soap and 

shampoo.

Non-antibacterial soap 

and shampoo.

23 Placebo No dose information. Continuous

0.5 % topical (can't 

say)

Tetracycline 

hydrochloride

Placebo No dose information. 

Placebo No dose information. 

0.5% tetracycline = 0.22% 

tetracycline hcl + 0.28% 4-

epi-tracycline HCl. Nonantibacterial soaps and 

shampoo.

Non-antibacterial 

soaps and shampoo.

313 Placebo No dose information. Continuous

Tetracycline 0.5 % topical bid. 

hydrochloride

Placebo No dose information. 

Placebo No dose information. 

C.08.03 255 Continuous

Discrete

Placebo No dose information. 

Tetracycline No dose information. 

Placebo No dose information. 

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table C HEADING: Page 4 of 5
CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

Benzoyl 5 % topical qd. 

peroxide

C.09.01 114 Triclosan No dose information. Non-medicated soap. Vehicle No dose information. Non-medicated soap. Continuous

The vehicle is a surface 

cleanser; the active drug is 

an antibacterial agent; 

trichlorohydroxyliphenyleth

er. 

This is a combination 

antibacterial and 

detergent. 

C.09.02 21 Triclosan No dose information. Unknown No dose information. Discrete

C.09.03 114 Propylene 0.75 % topical bid. Non-medicated soap. Continuous

phenoxetol

Triclosan 0.1 % topical bid. 

Vehicle No dose information. 

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table C HEADING: Page 5 of 5