Evidence Table D1. Articles/arms for class ANTI-BACTERIAL (TOPICAL)/KERATOLYTIC (TOPICAL)

CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

Basis®. Loroxide® base. 

Basis®.

D.01.01 97 Continuous

Discrete

5.5 % topical (1 to 4 (M)

times daily)

Benzoyl 

peroxide

Vehicle No dose information. 

173 Continuous

Discrete

Benzoyl 5 % topical bid. 

peroxide

Vehicle No dose information. 

Vehicle of 

gluconolactone. 

176 Continuous

Discrete

5 % topical (can't 

say)

Benzoyl 

peroxide

Vehicle No dose information. 

241 Benzoyl 2.5 % topical bid. Non-medicated soap. Non-medicated soap. Continuous

peroxide

Vehicle No dose information. 

Application once daily in 

first week. 

Application once daily 

in first week. 

314 Continuous

Discrete

Benzoyl 20 % topical bid. 

peroxide

Vehicle No dose information. 

D.01.03 176 Continuous

Discrete

5 % topical (can't 

say)

Benzoyl 

peroxide

14 % topical (can't 

say)

Gluconolactone

Wash affected area once or 

twice a day. 

Wash affected area 

once or twice a day. 

D.01.04 304 Benzoyl 10 % topical qd. Continuous

peroxide

Salicylic acid 2 % topical qd. 

D.01.05 272 Benzoyl No dose information. Continuous

peroxide

3 % topical (can't 

say)

Resorcinol

5 % topical (can't 

say)

Sulphur

D.01.09 76 Continuous

Discrete

5 % topical (can't 

say)

Benzoyl 

peroxide

5 % topical (can't 

say)

Benzoyl 

peroxide

Initially, daily washed off 

after 1-2 hrs.; advanced to 

bid after tolerated 

overnight x 3 nights. 

Initially, daily washed 

off after 1-2 hrs; 

advanced to bid after 

tolerated overnight x 3 

nights. 

118 Continuous

Discrete

Benzoyl 5 % topical bid. 

peroxide

Benzoyl 5 % topical bid. 

peroxide

149 Continuous

Discrete

Benzoyl 5 % topical bid. (M)

peroxide

Benzoyl 10 % topical bid. 

peroxide

4 weeks 5%; 4 weeks 10%; 

once or twice/day. 

221 Continuous

Discrete

Benzoyl 5 % topical qd. 

peroxide

Benzoyl 5 % topical qd. 

peroxide

The 2.5% formulation 

vehicle was different from 

that of 5% bp. Nonmedicated soap.

Vehicle of 5% bp 

different from that of 

2.5% bp. Nonmedicated soap.

242 2.5 % topical (can't Continuous

say)

Benzoyl 

peroxide

Benzoyl 5 % topical bid. 

peroxide

243 Benzoyl 2.5 % topical bid. The 2.5% formulation Benzoyl 10 % topical bid. Non- medicatedsoap. Continuous

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table D HEADING: Page 1 of 4
CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

vehicle was different from 

that of 10% bp. Nonmedicated soap.

peroxide peroxide Discrete

351 Benzoyl 2.5 % topical bid. Soap. Soap. Discrete

peroxide

Benzoyl 5 % topical bid. 

peroxide

D.01.10 278 Combination lotion. Continuous

Discrete

Urea 8 % topical bid. 

Benzoyl 5 % topical bid. 

peroxide

Benzoyl 5 % topical bid. 

peroxide

D.03.01 310 Continuous

Discrete

Zinc sulphur No dose information. 

Glycolic acid No dose information. 

Benzoyl 10 % topical bid. 

peroxide

Placebo No dose information. 

D.03.02 16 Hydrocortisone 1 % topical tid. Soap. Soap. Discrete

Benzoyl 10 % topical tid. 

peroxide

Hydroxyquinoli 0.5 % topical tid. 

ne

Benzoyl 10 % topical tid. 

peroxide

Hydroxyquinoli 0.5 % topical tid. 

ne

177 Continuous

Discrete

Hydrocortisone 1 % topical bid. (M)

Potassium 0.5 % topical bid. 

hydroxyquinoli

ne

Benzoyl 10 % topical bid. 

peroxide

Potassium 0.5 % topical bid. 

hydroxyquinoli

ne

Benzoyl 10 % topical bid. 

peroxide

D.03.04 82 Sulphur 5 % topical bid. Discrete

Benzoyl 10 % topical bid. 

peroxide

Sulphur 5 % topical bid. 

D.04.01 214 Continuous

Discrete

Benzoyl 5 % topical qhs. (M)

peroxide

Clindamycin 1 % topical qhs. 

Vehicle No dose information. 

D.05.01 310 Continuous

Discrete

Erythromycin 3 % topical bid. 

Benzoyl 5 % topical bid. 

peroxide

Placebo No dose information. 

D.05.015 53 Erythromycin 3 % topical bid. Combined product. Benzoyl 5 % topical bid. Continuous (M)

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table D HEADING: Page 2 of 4
CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

peroxide

D.05.02 260 Continuous

Discrete

Benzoyl 5 % topical bid. 

peroxide

Erythromycin 3 % topical bid. 

Clindamycin No dose information. 

phosphate

D.05.03 310 Continuous

Discrete

Erythromycin 3 % topical bid. 

Benzoyl 5 % topical bid. 

peroxide

Zinc sulphur No dose information. 

Glycolic acid No dose information. 

Benzoyl 10 % topical bid. 

peroxide

D.05.04 62 Continuous

Discrete

Erythromycin 3 % topical bid. 

Benzoyl 5 % topical bid. 

peroxide

Erythromycin 4 % topical bid. 

Zinc 1.2 % topical bid. 

A.M. Only for first week; 

wash off after 3 hrs. For 

first 3 weeks. 

A.M. Only for first 

week; wash off after 3 

hrs for for first 3 weeks. 

D.06.01 30 Continuous

Discrete

Benzoyl 5 % topical qd. 

peroxide

Meclocycline 1 % topical qd. 

Benzoyl 5 % topical bid. 

peroxide

D.07.01 121 Metronidazole 2 % topical bid. Discrete

Benzoyl 5 % topical bid. 

peroxide

Vehicle No dose information. 

D.07.02 122 Metronidazole 2 % topical bid. Discrete

Benzoyl 5 % topical bid. 

peroxide

Benzoyl 5 % topical bid. 

peroxide

D.08.01 85 Combination cream. Continuous

Discrete

Benzoyl 5 % topical bid. 

peroxide

Miconazole 2 % topical bid. 

Benzoyl 5 % topical bid. 

peroxide

111 Miconazole 2 % topical bid. Continuous

Benzoyl 5 % topical bid. 

peroxide

Benzoyl 5 % topical bid. 

peroxide

231 Qhs 1st week. Qhs 1st week. Continuous

Discrete

Miconazole 2 % topical bid. 

Benzoyl 5 % topical bid. 

peroxide

Benzoyl 5 % topical bid. 

peroxide

Isoconazole nitrate 1% 

application in the 

morning and 5% bp 

D.08.02 335 Continuous

Discrete

Miconazole 2 % topical bid. 

nitrate

Benzoyl 5 % topical qd. 

peroxide

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table D HEADING: Page 3 of 4
CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

Benzoyl 5 % topical bid. applied in the evening. 

peroxide

Isoconazole 1 % topical qd. 

nitrate

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table D HEADING: Page 4 of 4