**Exhibit 31.1**

 

CERTIFICATION

 

I, Scott R. Pancoast, Chief Executive Officerof Lpath, Inc. (the “Registrant”), certify that: 

 

1.                     I have reviewed this quarterly report on Form 10-QSBof the Registrant;

 

2.                     Based on my knowledge, this report does not containany untrue statement of a material fact or omit to state a material factnecessary to make the statements made, in light of circumstances under whichsuch statements were made, not misleading with respect to the period covered bythis report;

 

3.                     Based on my knowledge, the financial statements, andother financial information included in this report, fairly present in allmaterial respects the financial condition, results of operations and cash flowsof the Registrant as of, and for, the periods presented in this report.

 

4.                     The Registrant’s other certifying officer and I areresponsible for establishing and maintaining disclosure controls and procedures(as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) for the Registrantand have:

 

a)                    Designed such disclosure controls and procedures, orcaused such disclosure controls and procedures to be designed under oursupervision, to ensure that material information relating to the Registrant,including its consolidated subsidiaries, is made known to us by others withinthose entities, particularly during the period in which this report is beingprepared;

 

b)                   Evaluated the effectiveness of the Registrant’sdisclosure controls and procedures and presented in this report our conclusionsabout the effectiveness of the disclosure controls and procedures, as of theend of the period covered by this report based on such evaluation; and

 

c)                    Disclosed in this report any change in theRegistrant’s internal control over financial reporting that occurred during theRegistrant’s most recent fiscal quarter (the Registrant’s fourth fiscal quarterin the case of an annual report) that has materially affected, or is reasonablylikely to materially affect, the Registrant’s internal control over financialreporting; and

 

5.                     The Registrant’s other certifying officer and I havedisclosed, based on our most recent evaluation of internal control overfinancial reporting, to the Registrant’s auditors and the audit committee ofthe Registrant’s board of directors (or persons performing the equivalentfunctions):

 

(a)                All significant deficiencies and material weaknessesin the design or operation of internal control over financial reporting whichare reasonably likely to adversely affect the Registrant’s ability to record,process, summarize and report financial information; and

 

(b)               Any fraud, whether or not material, thatinvolves management or other employees who have a significant role in theRegistrant’s internal control over financial reporting.

 
|                  Date:  November 13, 2007 |   | By:   /s/  Scott R. Pancoast                                  |
|----------------------------------------------------------------------------------------------------------------------|--------|-------------------------------------------------------------------------|
|                                                                                                                 |   | Scott R. Pancoast  Chief Executive Officer(Principal Executive Officer) |