Evidence Table K1. Articles/arms for class RETINOID (ORAL).

CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

K.02.01 269 Continuous

Discrete

0.5 mg/kg oral (can't 

say)

Isotretinoin Placebo No dose information. 

K.02.02 276 Continuous

Discrete

Isotretinoin 40 mg oral qd. Dapsone 100 mg oral qd. 

Dosage increments of 0.5 

mg/kg/day were permitted 

at biweekly intervals to a 

maximum dose of 2.0 

mg/kg/day. Number of 

doses per day not 

specified. 

Starting at 250mg/d 

dosage increments of 

250mg/day. 

K.02.03 206 Continuous

Discrete

Isotretinoin 1 mg\kg\day oral qd. Tetracycline 1000 mg oral qd. 

hydrochloride

K.02.04 127 Isotretinoin 20 mg oral qd. With main meal. Alitretinoin 20 mg oral qd. With main meal. Discrete

Provided to nearest 10 

mg/kg capsule. 

Hydrocortisone ointiment 

1% as needed..

Provided to nearest 10 

mg capsule. 

Hydrocortisone 

ointment 1 % is needed..

K.02.05 130 Continuous

Discrete

Isotretinoin 0.5 mg/kg oral bid. Etretinate 0.5 mg/kg oral qd. 

K.02.06 5 Isotretinoin 0.5 mg/kg oral qd. Isotretinoin 0.3 mg/kg oral qd. Discrete

Isotretinoin 0.5 mg/kg oral qd. Isotretinoin 0.1 mg/kg oral qd. Discrete

Isotretinoin 0.3 mg/kg oral qd. Isotretinoin 0.1 mg/kg oral qd. Discrete

Hydrocortisone 1% + 

emollient.

Hydrocortisone 1% + 

emollient.

106 Istretinoin 0.05 mg/kg oral bid. Isotretinoin 0.5 mg/kg oral bid. 

185 Continuous

Discrete

1 mg/kg oral (can't 

say)

Isotretinoin 0.1 mg/kg oral (can't 

say)

Isotretinoin

Continuous

Discrete

1 mg/kg oral (can't 

say)

Isotretinoin 0.5 mg/kg oral (can't 

say)

Isotretinoin

Continuous

Discrete

0.5 mg/kg oral (can't 

say)

Isotretinoin 0.1 mg/kg oral (can't 

say)

Isotretinoin

190 1 mg/kg oral (can't 

say)

Isotretinoin

320 Continuous

Discrete

Isotretinoin 0.5 mg/kg oral qd. Isotretinoin 1 mg/kg oral qd. 

Continuous

Discrete

Isotretinoin 0.5 mg/kg oral qd. Isotretinoin 0.1 mg/kg oral qd. 

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table K HEADING: Page 1 of 2
CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

K.02.06 320 Continuous

Discrete

Isotretinoin 1 mg/kg oral qd. Isotretinoin 0.5 mg/kg oral qd. 

Continuous

Discrete

Isotretinoin 1 mg/kg oral qd. Isotretinoin 0.1 mg/kg oral qd. 

No concomitant topical 

or systemic acne 

therapy..

332 Continuous

Discrete

1 mg/kg oral (can't 

say)

Isotretinoin Isotretinoin 0.5 mg/kg oral qd. 

Ancillary treatment was 

allowed but not required. 

Sulfurated potash and zinc 

lotion, topically.

K.03.01 12 Vitamin A 50000 iu oral tid. Placebo No dose information. Discrete

Dispatabs® (US); 150,000 

IU bid if 60kg or less, or 

200,000 IU if over 60kg. 

Dissolved in water and 

taken after meals. 

K.03.02 233 Continuous

Discrete

Vitamin A 15000 IU oral bid. (M)

palmitate

Zinc sulfate 0.2 g oral tid. 

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table K HEADING: Page 2 of 2