Evidence Table H1. Articles/arms for class ANTI-BACTERIAL (ORAL).

CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

Qid 1 week, tid 1 week, 

then bid. Chosen by patient 

and included: antibacterial 

soaps, antibacterial 

cleanser, various peeling 

agents. Encouraged not to 

start/stop ancillary 

treatment after initiation of 

study.

Qid 1 week, tid 1 week, 

then bid. Chosen by 

patient and included: 

antibacterial soaps, 

antibacterial cleanser, 

various peeling agents. 

Encouraged not to 

start/stop ancillary 

treatment after 

initiation of study.

H.01.01 56 Continuous

Discrete

Clindamycin 150 mg oral bid. Vehicle No dose information. 

Pernox® nightly; Transact 

bid.

Pernox® nightly; 

Transact bid.

H.01.02 265 Continuous

Discrete

150 mg oral (qid 1 

week; tid second 

week then bid)

Clindamycin 250 mg oral (qid one 

week; tid week 2 

then bid)

Tetracycline

Non-antibacterial soap and 

shampoo.

Non-antibacterial soap 

and shampoo.

275 Clindamycin 150 mg oral qd. Discrete

hydrochloride

Tetracycline 250 mg oral bid. 

hydrochloride

H.02.01 71 Demethylchlort 150 mg oral qid. Discrete

etracycline

Vehicle No dose information. 

Well-known soap and 

bedtime lotion.

162 Demethylchlort 150 mg oral qid. Discrete

etracycline

Placebo No dose information. 

Supply taken until 

exhausted. Common acne 

cleansers and drying 

lotions.

Supply taken until 

exhausted (24 

capsules). Common 

acne cleansers and 

drying lotions.

192 Demethylchlort 150 mg oral qd. Discrete

etracycline

Placebo No dose information. 

24 tabs provided and told 

to complete. 

193 Demethylchlort 150 mg oral qhs. Discrete

etracycline

Placebo No dose information. 

312 After meals. 1/2 hour after meals. Continuous

Discrete

Demethylchlort 150 mg oral qid. 

etracycline

Placebo No dose information. 

H.02.02 312 After meals. 1/2 hr. Before meals. Continuous

Discrete

Demethylchlort 150 mg oral qid. 

etracycline

Phenethicillin 250 mg oral qid. 

Qid until response, then 

reduced to tid, bid, qd, as 

tolerated, and until a total 

of 300 capsules used. 

H.02.03 70 Demethylchlort 150 mg oral tid. Discrete

etracycline

Tetracycline 250 mg oral tid. 

71 Demethylchlort 150 mg oral qid. Tetracycline 250 mg oral qid. Discrete

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table H HEADING: Page 1 of 7
CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

etracycline hydrochloride

H.03.01 273 2 capsules in A.M. 2 capsules in A.M. Continuous

Discrete

Doxycycline 200 mg oral qd. Placebo No dose information. 

H.03.02 1 Continuous

Discrete

Doxycycline 50 mg oral qd. Fusidin 2 % topical qhs. 

For 2 weeks bid; then one 

cap 90d. Tioxolon® 

powder 0.1%.

500 mg bid x 2 weeks; 

then 250 mg bid x 4 

weeks. Tioxolon® 

powder 0.1%.

H.03.03 25 Placebo No dose information. Continuous

Doxycycline 100 mg oral (qod)

Placebo No dose information. 

Erythromycin 250 mg oral bid. 

stearate

Chlorhexidine 4% + 

benzoyl peroxide 5%..

Chlorhexidine 4% + 

benzyol peroxide 5%..

H.03.04 155 Continuous

Discrete

Doxycyline 50 mg oral qd. Minocycline 50 mg oral bid. 

Reduced to qd after 4 

weeks. 

Reduced to qd after 4 

weeks. 

257 Continuous

Discrete

Placebo No dose information. 

Doxycycline 50 mg oral bid. 

Placebo No dose information. 

Minocycline 50 mg oral bid. 

5% salicylic acid & 5% 

resorcinolin spir dit. Ket. 

Preparation applied twice 

a day.

5% salicylic acid & 5% 

resorcinolin spir dit. 

Ket. Preparation 

applied twice a day.

311 Continuous

Discrete

Doxycycline 100 mg oral qhs. Minocycline 100 mg oral qhs. 

Local treatment with 

Tioxolon® (camyra powder 

0.1%, bid).

Local treatment with 

Tioxolon® (camyra 

powder 0.1 %, bid).

H.04.02 24 Continuous

Discrete

Erythromycin 500 mg oral bid. Erythromycin 500 mg oral bid. 

H.04.03 6 Erythromycin 250 mg oral bid. Tetracycline 250 mg oral bid. Discrete

Week 1: 400 mg bid; week 

2: 200 mg bid; following 

weeks: 200 mg qd. 

Week 1: 500 mg bid; 

week 2: 250 mg bid; 

following weeks: 250 

mg qd. 

36 Continuous

Discrete

Erythromycin 200 mg oral qd. 

acistrate

Tetracycline 250 mg oral qd. 

Erythromycin tid for first 4 

weeks; placebo bid for first 

4 weeks. Gently wash 

affected area twice daily 

with Purpose®.

Tetracycline bid for 

first 4 weeks; placebo 

tid for first 4 weeks. 

Gently wash affected 

area twice daily with 

Purpose® ®soap.

125 Continuous

Discrete

Placebo No dose information. 

Erythromycin 500 mg oral qd. 

Placebo No dose information. 

Placebo No dose information. 

Tetracycline No dose information. 

H.04.04 340 Erythromycin No dose information. Discrete (M)

proprionate

Triacetyl- No dose information. 

oleandomycin

Erythromycin No dose information. Dosage described as "3 Triacetyl- No dose information. Discrete (M)

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table H HEADING: Page 2 of 7
CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

doses daily for at least 60 

days and after that they 

(pts) could adjust the dose 

as they felt they needed to 

do.". Acne surgery done by 

the author; resorciline 

sulfur preparation once 

daily, usually at bedtime.

stearate oleandomycin

H.04.05 4 Roxithromycin 150 mg oral qd. Roxithromycin 300 mg oral qd. Discrete

H.04.06 247 Oleandomycin 250 mg oral qid. Triacetyl- 250 mg oral qid. Discrete

oleandomycin

200 mg qd x1 week, then 

100 mg qd x 4 weeks. 

Identical in appearance 

to minocycline. 

H.05.01 161 Continuous

Discrete

Minocycline 100 mg oral qd. Placebo No dose information. 

H.05.02 268 Simple soap twice daily. Simple soap twice daily. Continuous

Discrete

Minocycline 50 mg oral qd. Clindamycin 1 % topical bid. 

307 Placebo No dose information. Before meals. Applied to entire face. Continuous

Minocycline 50 mg oral bid. 

Placebo No dose information. 

Clindamycin 1 % topical bid. 

phosphate

H.05.04 72 Continuous

Discrete

Minocycline 50 mg oral bid. Tetracycline 250 mg oral bid. 

171 Minocycline 50 mg oral bid. Tetracycline 250 mg oral bid. 

hydrochloride

298 Continuous

Discrete

Minocycline 50 mg oral bid. Tetracycline 250 mp oral bid. 

Before meal; cross to 

placebo at 1 to 3 months. 

Standard program = hands 

off, soap and water 3x day, 

apply prescribed 

resocrinol and sulfur shake 

lotion at night, keep hair 

clean, take sun baths.

Before meal; cross to 

oxytetracycline at 1 to 

3 months. Standard 

program = hands off, 

soap and water 3x day, 

apply prescribed 

resocrinol and sulfur 

shake lotion at night, 

keep hair clean, take 

sun baths.

H.06.01 250 Oxytetracycline 125 mg oral qd. Placebo No dose information. Discrete

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table H HEADING: Page 3 of 7
CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

H.06.02 255 Continuous

Discrete

Oxytetracycline 250 mg oral bid. 

Vehicle No dose information. 

Placebo No dose information. 

Benzoyl 5 % topical qd. 

peroxide

Tablets taken 30minutes 

before meals. 

H.06.03 123 Vehicle No dose information. Discrete

Oxytetracycline 250 mg oral bid. 

Placebo No dose information. 

Metronidazole 2 % topical bid. 

Benzoyl 5 % topical bid. 

peroxide

1.25mg/day n-decyl methyl 

sulphoxide. Oral 

tetracycline 1000mg/day 

1st 4 weeks, 500 day next 4 

weeks, out of 16 weeks 

total study duration.

Oral tetracycline-1000 

mg/day 1st 4 weeks, 

500 mg/day next 4 

weeks out of 16 weeks 

total study duration.

H.06.045 40 Continuous

Discrete

Tetracycline 2.2 % topical bid. Placebo 70 ml topical bid. 

H.06.05 255 Continuous

Discrete

Oxytetracycline 250 mg oral bid. 

Vehicle No dose information. 

Placebo No dose information. 

Tetracycline No dose information. 

H.06.06 152 Continuous

Discrete

Oxytetracycline 250 mg oral bid. Sulphamethoxa 400 mg oral bid. 

zole

Trimethoprim 80 mg oral bid. 

Tid for 4 weeks then bid. Tid for 4 weeks then 

bid. 

H.06.07 128 Continuous

Discrete

Oxytetracycline 250 mg oral tid. Trimethoprim 100 mg oral tid. 

H.07.01 160 Sulphamethoxa 400 mg oral qd. Continuous

zole

Trimethoprim 80 mg oral qd. 

Vehicle No dose information. 

Strength of tablet not 

mentioned. Washing with 

soap.

223 Washing with soap. Continuous

Discrete

Cotrimoxazole No dose information. Placebo No dose information. 

1 g bid for 1 week; 0.5 g qd 

for 4 weeks. Cleaning soap 

and water; exposure to 

Westinghouse® sun lamp 

acne lotion.

H.07.02 41 Sulfadimethoxin 500 mg oral bid. Discrete

e

Placebo No dose information. 

H.08.01 10 Continuous

Discrete

Tetracycline 250 mg oral bid. 

Vehicle No dose information. 

Placebo 250 mg oral bid. 

Vehicle No dose information. 

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table H HEADING: Page 4 of 7
CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

Non-antibacterial soap 

and shampoo.

H.08.01 23 Tetracycline 250 mg oral bid. Continuous

hydrochloride

Placebo No dose information. 

Placebo No dose information. 

Placebo No dose information. 

33 Continuous

Discrete

Vehicle No dose information. 

Tetracycline 250 mg oral bid. 

Vehicle No dose information. 

Vehicle No dose information. 

Qid x 2 wks, then tid x 4 

wks, then bid. 

Local treatment was 

one or combination of 

lotion, ointment or 

pastes and cryotherapy. 

Active ingredients were 

not mentioned. 

69 Tetracycline 250 mg oral bid. Topical No dose information. Discrete

treatment

71 Tetracycline 250 mg oral qid. Discrete

hydrochloride

Vehicle No dose information. 

Placebo for clindamycin. 

Vehicle isopropyl 

alcohol+water. 

Placebo solution 

vehicle isopropyl 

alcohol water. Placebo 

for tetracycline and for 

clindamycin. 

136 Continuous

Discrete

Placebo No dose information. 

Tetracycline 250 mg oral bid. 

hydrochloride

Placebo solution No dose information. 

Placebo capules No dose information. 

201 Continuous

Discrete

Tetracycline 250 mg oral bid. Placebo No dose information. 

Non-antibacterial soaps 

and shampoo.

Non-antibacterial 

soaps and shampoo.

313 Placebo No dose information. Continuous

Tetracycline 250 mg oral bid. 

hydrochloride

Placebo No dose information. 

Placebo No dose information. 

Capsule taken on empty 

stomach every morning & 

evening, one hour before 

or 2 hours after meals. 

Dabbed on skin every 

morning and night after 

washing. 

H.08.02 29 Vehicle No dose information. Continuous

Tetracycline 250 mg oral bid. 

Placebo No dose information. 

Clindamycin 1 % topical bid. 

phosphate

Clindamycin pH 

adjusted. 

33 Continuous

Discrete

Vehicle No dose information. 

Tetracycline 250 mg oral bid. 

Vehicle No dose information. 

Clindamycin No dose information. 

Placebo for clindamycin. 

Vehicle isopropyl 

alcohol+water. 

Placebo for 

tetracycline. Vehicle 

isopropyl 

alcohol+water. 

136 Continuous

Discrete

Placebo No dose information. 

Tetracycline 250 mg oral bid. 

hydrochloride

Placebo No dose information. 

Clindamycin 1 % topical bid. 

phosphate

Placebo (topical) for 1st 3 

weeks, 2x1day. For 

remainder of 9 weeks: 

250mg (2 x day) + placebo 

(topical) (2x day). 

4 pts. Missed more than 

1 follow-up visit; 5 had 

too many lesions; and, 

7 had too few papules. 

186 Continuous

Discrete

Tetracycline 500 mg oral bid. 

hydrochloride

Placebo No dose information. 

Clindamycin 1 % topical bid. 

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table H HEADING: Page 5 of 7
CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

Placebo for Clindamycin 

phosphate. 

Placebo for 

tetracycline. 

H.08.02 318 Placebo No dose information. 

Tetracycline 250 mg oral bid. 

Clindamycin No dose information. 

phosphate

H.08.03 279 Continuous

Discrete

Placebo No dose information. 

Tetracycline 250 mg oral bid. 

hydrochloride

Placebo No dose information. 

Erythromycin 1.5 % topical bid. 

H.08.04 10 Continuous

Discrete

Tetracycline 250 mg oral bid. 

Vehicle No dose information. 

Placebo 250 mg oral bid. 

Tetracycline 0.5 % topical bid. 

Non-antibacterial soap 

and shampoo.

23 Tetracycline 250 mg oral bid. Continuous

hydrochloride

Placebo No dose information. 

Placebo No dose information. 

0.5 % topical (can't 

say)

Tetracycline 

hydrochloride

Non-antibacterial soaps 

and shampoo.

0.5% tetracycline = 

0.22% tetracycline hcl 

+ 0.28% 4-epitracycline HCl. Nonantibacterial soaps and 

shampoo.

313 Placebo No dose information. Continuous

Tetracycline 250 mg oral bid. 

hydrochloride

Placebo No dose information. 

Tetracycline 0.5 % topical bid. 

hydrochloride

H.08.05 22 Continuous

Discrete

Tetracycline 250 mg oral qid. Azelaic acid 20 % topical bid. 

1000 mg/day for first 

month, 750 mg/day for 

second. 

166 Continuous

Discrete

500 mg oral (can't 

say)

Tetracycline 

hydrochloride

Placebo No dose information. 

Placebo No dose information. 

Azelaic acid 20 % topical bid. 

1000 mg /day for first 

month, 750 mg/day for the 

second month, 500 mg/day 

for third month, then 

adjusted as needed. 

167 Continuous

Discrete

Placebo No dose information. 

Tetracycline 500 mg oral ()

hydrochloride

Placebo No dose information. 

Azelaic acid 20 % topical bid. 

The placebo cream is the 

vehicle base of 

meclosorb®. 

H.08.06 164 Tetracycline 250 mg oral bid. Continuous

Vehicle No dose information. 

Placebo No dose information. 

Meclocycline 1 % topical bid. 

sulfosalicylate

1st month bid; 2nd qd; 3rd 

every other day. Usual 

cosmetics and soap.

1st month bid; 2nd qd; 

3rd every other day. 

Usual cosmetics and 

soap.

H.08.08 212 Tetracycline 250 mg oral qd. Tetracycline 250 mg oral bid. Discrete

hydrochloride

Enzymes: 

chymotropin/tryposin 1:6. 

317 Proteolytic 50000 units oral qid. Discrete

enzymes

Tetracycline 250 mg oral qid. 

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table H HEADING: Page 6 of 7
CompTrial Treatment Dose, route, frequency Comments, ancillary treatment

TARGET COMPARATOR Outcome

Table(s)

HEADING

Treatment Dose, route, frequency Comments, ancillary treatment

Tetracycline 250 mg oral qid. 

Enzymes: 

chymotropin/tryposin 

1:6. 

Tetracycline 250 mg oral qid. Proteolytic 50000 units oral qid. Discrete

enzymes

Tetracycline 250 mg oral qid. 

Tried for 2 weeks with 4 

capsules a day then 

increase or decrease but 

ideal was 4/d. Non 

abrasive soap; 1% 

salicyclic acid in ethyl 

alcohol; sulfur-resorcin 

lotion.

Non abrasive soap; 1% 

salicyclic acid in ethyl 

alcohol; sulfur-resorcin 

lotion.

H.08.085 299 Sodium 125 mg oral qid. 

novobiocin

Tetracycline 250 mg oral qid. 

Placebo No dose information. 

Povidone-iodine is bid to 

tid. 

H.08.14 236 Tetracycline 250 mg oral bid. Discrete

Povidone-iodine No dose information. 

Vehicle No dose information. 

Tetracycline 250 mg oral bid. 

H.09.01 293 Dapsone No dose information. Placebo No dose information. Discrete

H.09.02 312 1/2 hr. Before meals. 1/2 hour after meals. Continuous

Discrete

Phenethicillin 250 mg oral qid. Placebo No dose information. 

H.09.04 344 Fusidin 250 mg oral qd. Fusidin 2 % topical bid. Discrete

H.09.05 340 Tetracycline- No dose information. Discrete (M)

novobiocin

Placebo No dose information. 

"(M)" indicates that data are found on the Multi-Arm tables. Evidence Table H HEADING: Page 7 of 7