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###### Department of Health and Human Services

###### National Institutes of Health 

# AGENCY:

National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH). 

# ACTION:

Meeting announcement and request for comments. 

# SUMMARY:

Pursuant to Public Law 92-463, notice is hereby given of a meeting of the NTP Board of Scientific Counselors Technical Reports Review Subcommittee (TRR Subcommittee). The primary agenda topic is the peer review of the findings and conclusions presented in eight draft NTP Technical Reports of rodent toxicology and carcinogenicity studies in rats and mice conducted by the NTP (see Preliminary Agenda below). The TRR Subcommittee meeting is open to the public with time scheduled for oral public comment. The NTP also invites written comments on any draft technical report discussed at the meeting (see Request for Comments, below). The TRR Subcommittee deliberations on the draft technical reports will be reported to the NTP Board of Scientific Counselors (BSC) at a future date. 

# DATES:

                        The TRR Subcommittee meeting will be held on May 16 and 17, 2007. All individuals who plan to attend are encouraged to register online by May 9, 2007, at the NTP Web site (                        *http://ntp.niehs.nih.gov/​*                         select “Calendar of Upcoming Events”). Written comments on the draft reports should be received by May 2, 2007. Persons needing special assistance, such as sign language interpretation or other reasonable accommodation in order to attend, should contact 919-541-2475 (voice), 919-541-4644 TTY (text telephone), through the Federal TTY Relay System at 800-877-8339, or by e-mail to                         *niehsoeeo@niehs.nih.gov.*                         Requests should be made at least 7 days in advance of the event.                     

# ADDRESSES:

                         The TRR Subcommittee meeting will be held in the Rodbell Auditorium, Rall Building at the NIEHS, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709. Public comments and any other correspondence should be submitted to Dr. Barbara Shane, Executive Secretary for the NTP Board (NTP Liaison and Scientific Review Office, NIEHS, P.O. Box 12233, MD A3-01, Research Triangle Park, NC 27709; telephone: 919-541-4253, fax: 919-541-0295; or e-mail:                         *shane@niehs.nih.gov*).                     

# SUPPLEMENTARY INFORMATION:

## Background 

The primary agenda topic is the peer review of the findings and conclusions of eight draft NTP Technical Reports of rodent toxicology and carcinogenicity studies conducted by the NTP (see Preliminary Agenda below) in rats and mice. 

## Attendance and Registration 

                    The meeting is scheduled for May 16-17, 2007, from 8:30 a.m. to adjournment and is open to the public with attendance limited only by the space available. Individuals who plan to                           ( print page 9547)                        attend are encouraged to register online at the NTP Web site by May 9, 2007, at                     *http://ntp.niehs.nih.gov/​*                     select “Advisory Boards and Committees” to facilitate access to the NIEHS campus. Please note that a photo ID is required to access the NIEHS campus. The NTP is making plans to videocast the meeting through the Internet at                     *http://www.niehs.nih.gov/​external/​video.htm.*

## Availability of Meeting Materials 

                    A copy of the preliminary agenda, committee roster, and any additional information, when available, will be posted on the NTP Web site (                    *http://ntp.niehs.nih.gov/​*                     select “Calendar of Upcoming Events”) or may be requested in hardcopy from the Executive Secretary (see                     **ADDRESSES**                     above). Draft NTP Technical Reports will be posted on the NTP Web site (                    *http://ntp.niehs.nih.gov/​*                     select “Calendar of Upcoming Events”) after April 2, 2007. Following the meeting, summary minutes will be prepared and made available on the NTP Web site.                 

## Request for Comments 

                    Public input at this meeting is invited and time is set aside for the presentation of public comments on any draft technical report. Each organization is allowed one time slot per agenda topic. At least 7 minutes will be allotted to each speaker, and if time permits, may be extended to 10 minutes at the discretion of the chair. Persons wishing to make an oral presentation are asked to notify Dr. Barbara Shane via online registration, phone, or e-mail (see                     **ADDRESSES**                     above) by May 2, 2007, and if possible, to send a copy of the statement or talking points at that time. Written comments on the draft reports are also welcome and should also be received by May 2, 2007, to enable review by the TRR Subcommittee and NTP staff prior to the meeting. Written statements can supplement and may expand the oral presentation. If registering on-site and reading from written text, please bring 40 copies of the statement for distribution to the TRR Subcommittee and NTP staff and to supplement the record. Written comments received in response to this notice will be posted on the NTP Web site. Persons submitting written comments should include their name, affiliation, mailing address, phone, fax, e-mail, and sponsoring organization (if any) with the document. Registration for oral comments will also be available on-site, although time allowed for presentation by on-site registrants may be less than that for pre-registered speakers and will be determined by the number of persons who register at the meeting.                 

## Background Information on the NTP Board of Scientific Counselors 

The NTP Board of Scientific Counselors (BSC) is a technical advisory body comprised of scientists from the public and private sectors who provide primary scientific oversight to the overall program and its centers. Specifically, the BSC advises the NTP on matters of scientific program content, both present and future, and conducts periodic review of the program for the purposes of determining and advising on the scientific merit of its activities and their overall scientific quality. The TRR Subcommittee is a standing subcommittee of the BSC. BSC members are selected from recognized authorities knowledgeable in fields such as toxicology, pharmacology, pathology, biochemistry, epidemiology, risk assessment, carcinogenesis, mutagenesis, molecular biology, behavioral toxicology and neurotoxicology, immunotoxicology, reproductive toxicology or teratology, and biostatistics. Its members are invited to serve overlapping terms of up to four years. BSC and TRR Subcommittee meetings are held annually or biannually. 

Dated: February 22, 2007. 

Samuel H. Wilson, 

Deputy Director, National Institute of Environmental Health Sciences and National, Toxicology Program.

## Preliminary Agenda—National Toxicology Program (NTP) Board of Scientific Counselors Technical Reports Review 

## Subcommittee Meeting—May 16-17, 2007 

## Rodbell Auditorium, Rall Building, National Institute of Environmental Health Sciences—111 TW Alexander Drive, Research Triangle Park, NC 27709 

#### NTP Technical Reports (TR) Scheduled for Review 

    - TR 550: Cresols (CASNR 1319-77-3)

○ Used as solvents, disinfectants, preservatives, and in the production of fragrances, antioxidants, dyes, pesticides, and resins 
    - TR 542: Cumene (CASNR 98-82-8)

○ Used as a solvent and in the production of phenol, acetone and α-methylstyrene 
    - TR 547: Ethinyl Estradiol (CASNR 57-63-6)—Multigenerational Study

○ Synthetic steroidal estrogen; used as a component of oral contraceptives 
    - TR 548: Ethinyl Estradiol (CASNR 57-63-6)—2-year bioassay

○ Synthetic steroidal estrogen; used as a component of oral contraceptives 
    - TR 541: Formamide (CASNR 75-12-7)

○ Used as a solvent, water softener, in water soluble inks and as an intermediate in organic syntheses 
    - TR 551 Isoeugenol (CASNR 97-54-1)

○ Used as a food flavoring agent, fragrance, in the manufacture of vanillin, and to sedate fish; found naturally in cloves, tobacco and many other plants; prepared synthetically by heating eugenol 
    - TR 552: Propargyl Alcohol CASNR 107-19-7)

○ Used as a chemical intermediate, corrosion inhibitor, solvent stabilizer, and polymer modifier 
    - TR 546: Sodium Dichromate Dihydrate (CASNR 7789-12-0)

○ Inorganic compound containing hexavalent chromium. Used as a corrosion inhibitor, in the production of pigments, in electroplating, leather tanning, wood preservation, and textile manufacturing. Found as a contaminant in drinking water supplies

 [FR Doc. E7-3701 Filed 3-1-07; 8:45 am] 

BILLING CODE 4140-01-P