Federal Register / Vol. 72, No. 8 / Friday, January 12, 2007 / Notices 1549 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Government-Owned Inventions; 

Availability for Licensing 

AGENCY: National Institutes of Health, 

Public Health Service, HHS. 

ACTION: Notice. 

SUMMARY: The inventions listed below 

are owned by an agency of the U.S. 

Government and are available for 

licensing in the U.S. in accordance with 

35 U.S.C. 207 to achieve expeditious 

commercialization of results of 

federally-funded research and 

development. Foreign patent 

applications are filed on selected 

inventions to extend market coverage 

for companies and may also be available 

for licensing. 

ADDRESSES: Licensing information and 

copies of the U.S. patent applications 

listed below may be obtained by writing 

to the indicated licensing contact at the 

Office of Technology Transfer, National 

Institutes of Health, 6011 Executive 

Boulevard, Suite 325, Rockville, 

Maryland 20852–3804; telephone: 301/ 

496–7057; fax: 301/402–0220. A signed 

Confidential Disclosure Agreement will 

be required to receive copies of the 

patent applications. 

In Vivo Assessment of Tissue 

Microstructure and Microdynamics: 

Estimation of the Average Propagator 

From Magnetic Resonance Data 

Description of Technology: This 

invention relates to diffusion-weighted 

magnetic resonance imaging (DW–MRI) 

and describes a novel method for 

estimating the 3–D average propagator 

from DW–MRI data. The average 

propagator measures the probability that 

water molecules move from one place to 

another during a given diffusion time. 

This quantity provides local information 

about the tissue microstructure and the 

microenvironment in which water 

diffuses without making any a priori 

assumptions about the underlying 

diffusion process itself. Several 

methods, such as 3D q-space magnetic 

resonance imaging (MRI) and diffusion 

spectrum imaging have been developed 

to measure the average propagator, but 

these techniques currently require 

acquisition of large numbers of DW 

images, making them infeasible for 

routine animal and clinical imaging. 

The proposed methodology introduces a 

new data reconstruction concept, which 

involved using computer tomography 

(CT) algorithms to estimate the average 

propagator from the MR data. The 

proposed CT reconstruction requires 

many fewer DW–MRI data than 

conventional methods consistent with a 

clinically feasible period of MR image 

acquisition. The novel technique can be 

used to diagnose medical disorders that 

are associated with alterations in water 

diffusion, such as stroke and several 

neurodegenerative diseases and other 

disorders for which diffusion tensor 

MRI is currently used. Additional 

applications include drug development 

(screening drug candidates), material 

science (testing the quality of materials 

that have restricted and hindered 

compartments, e.g. porous media, gels 

and films) and food processing (testing 

structural changes in food). 

Applications: In vivo Functional MRI 

of humans and animals; Drug 

development; Material science; Food 

processing. 

Development Status: Early stage; only 

testing using fixed tissues and 

numerical phantoms have been 

performed at this time. 

Inventors: Peter J. Basser and Valery 

Pickalov (NICHD). 

Patent Status: U.S. Patent Application 

No. 11/407,096 filed 20 Apr 2006 (HHS 

Reference No. E–164–2006/0–US–01). 

Licensing Status: Available for nonexclusive or exclusive licensing, as well 

as for collaborative research, provided 

that non-disclosure agreements and 

MTAs have been executed. 

Licensing Contact: Chekesha S. 

Clingman, Ph.D.; 301/435–5018; 

clingmac@mail.nih.gov. 

Collaborative Research Opportunity: 

The NICHD Laboratory of Integrative 

and Medical Biophysics, Section on 

Tissue Biophysics and Biomimetics, is 

seeking statements of capability or 

interest from parties interested in 

collaborative research to further 

develop, evaluate, or commercialize this 

technology. Please contact Peter J. 

Basser, Ph.D. at pjbasser@helix.nih.gov 

for more information. 

Fast Electron Paramagnetic Resonance 

Imaging (EPRI) Using CW–EPR 

Spectrometer With Sinusoidal RapidScan and Digital Signal Processing 

Description of Technology: Electron 

Paramagnetic Resonance (EPR) Imaging 

is an indispensable tool that may be 

applied to a variety of disciplines for 

evaluation of chemical species having 

unpaired electrons such as free radicals 

and transition metal ions. In Continuous 

Wave (CW)–EPR the sample is 

continuously irradiated with weak RF 

radiation while sweeping the magnetic 

field relatively slowly. Existing CW–

EPR techniques utilize a signal 

detection method known as phasesensitive detection which results in data 

acquisition times that are too long for in 

vivo applications. The present 

technology represents significant 

improvements on conventional CW–

EPR. 

The subject technology includes three 

approaches to collecting image data 

with increased spatial, temporal and 

spectral resolution and improved 

sensitivity. Spectral data acquisition is 

performed by a direct detection strategy 

involving mixing a signal to base-band 

and acquiring data with a fast-digitizer. 

Projection data is acquired using a 

sinusoidal magnetic field sweep under 

gradient magnetic fields. Data collection 

times are decreased with the utility of 

rotating gradients. Further, the current 

technology improves sensitivity by 

employing Digital Signal Processing, 

which decreases background analog 

noise. 

Increased speed and sensitivity makes 

CW–EPR a potentially useful and 

complementary tool to Magnetic 

Resonance Imaging for in vivo imaging. 

The presently described improvements 

to CW–EPR will allow changes of blood 

perfusion and oxygenation in tumors to 

be observed in nearly real-time, while 

improved resolution will permit 

angiogenesis in and around tumors to be 

carried out in a non-invasive manner. 

Additionally, rapid scan imaging 

provides excellent temporal resolution 

and will help quantify pharmacokinetics and metabolic degradation 

kinetics of bioactive free radicals. 

Applications: (1) Enhanced spatial, 

temporal, and spectral resolution of 

Continuous Wave-Electron 

Paramagnetic Resonance Imaging; (2) 

Real-time assessment of changes in 

blood perfusion and oxygenation. 

Development Status: Preliminary 

experiments have been conducted and 

the technology has been tested for 

feasibility. 

Inventors: Sankaran Subramanian, 

Nallathamby Devasahayam, Janusz 

Koscielniak, James Mitchell, and Murali 

Krishna (NCI). 

Publication: S Subramanian, JW 

Koscielniak, N Devasahayam, RH 

Pursley, TJ Pohida, TJ Pohida, MC 

Krishna. A new strategy for fast 

radiofrequency CW–EPR imaging: Direct 

detection with rapid scan and rotating 

gradients. Submitted to Journal of 

Magnetic Resonance for publication. 

Patent Status: U.S. Provisional 

Application No. 60/818,052, filed 30 Jun 

2006 (HHS Reference No. E–221–2005/ 

0–US–01). 

Licensing Status: Available for nonexclusive or exclusive licensing and 

commercial development. 


rmajette on PROD1PC67 with NOTICES
1550 Federal Register / Vol. 72, No. 8 / Friday, January 12, 2007 / Notices 

Licensing Contact: Chekesha S. 

Clingman, PhD; 301/435–5018; 

clingmac@mail.nih.gov. 

Collaborative Research Opportunity: 

The Radiation Biology Branch, National 

Cancer Institute, NIH, Bethesda, MD is 

seeking statements of capability or 

interest from parties interested in 

collaborative research to further 

develop, evaluate, or commercialize the 

above Rapid scan-Rotating gradients 

strategy for performing routine in vivo 

Radiofrequency CW–EPR imaging in 

small animals. Please contact John D. 

Hewes, PhD at 301–435–3121 or 

hewesj@mail.nih.gov for more 

information. 

Dated: January 5, 2007. 

Steven M. Ferguson, 

Director, Division of Technology Development 

and Transfer, Office of Technology Transfer, 

National Institutes of Health. 

[FR Doc. E7–350 Filed 1–11–07; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Heart, Lung, and Blood 

Institute; Notice of Closed Meetings 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. Appendix 2), notice 

is hereby given of the following 

meetings. 

The meetings will be closed to the 

public in accordance with provisions set 

forth in sections 552b(c)(4) and 

552b(c)(6), Title 5 U.S.C., as amended. 

The grant applications and the 

discussions could disclose confidential 

trade secrets or commercial property 

such as patentable material, and 

personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Heart, Lung, 

and Blood Institute Special Emphasis Panel; 

Conference Grants (R13). 

Date: January 24, 2007. 

Time: 8 a.m. to 9 a.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892 

(Telephone Conference). 

Contact Person: Valerie L. Prenger, PhD, 

Scientific Review Administrator, Review 

Branch, Room 7214, Division of Extramural 

Research Activities, National Heart, Lung, 

and Blood Institute, 6701 Rockledge Drive, 

MSC 7294, Bethesda, MD 20892–7294, (301) 

435–0270, prengerv@nhibi.nih.gov. 

Name of Committee: National Heart, Lung, 

and Blood Institute Special Emphasis Panel; 

Shared Resource Grant (R24). 

Date: January 25, 2007. 

Time: 3 p.m. to 4:30 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892 

(Telephone Conference Call). 

Contact Person: Shelley S. Sehnert, PhD, 

Scientific Review Administrator, Review 

Branchy, NIH/NHLBI, 6701 Rockledge Drive, 

Room 7206, Bethesda, MD 20892–7294, (301) 

435–0303, ssehnert@nhlbi.nih.gov. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.233, National Center for 

Sleep Disorders Research; 93.837, Heart and 

Vascular Diseases Research; 93.838, Lung 

Diseases Research; 93.839, Blood Diseases 

and Resources Research, National Institutes 

of Health, HHS) 

Dated: January 8, 2007. 

Anna Snouffer, 

Acting Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 07–101 Filed 1–11–07; 8:45 am] 

BILLING CODE 4140–01–M 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Institute of Nursing Research; 

Notice of Closed Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. Appendix 2), notice 

is hereby given of the following 

meeting. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Institute of 

Nursing Research Initial Review Group. 

Date: March 5–6, 2007. 

Time: 8:15 a.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: Crowne Plaza Hotel, 8777 Georgia 

Avenue, Silver Spring, MD 20910. 

Contact Person: Jeffrey M. Chernak, PhD, 

Scientific Review Administrator, Office of 

Review, National Institute of Nursing 

Research, 6701 Democracy Plaza, Suite 710, 

MSC 4870, Bethesda, MD 20892, (301) 402–

6959, chernak@nih.gov. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.361, Nursing Research, 

National Institutes of Health, HHS) 

Dated: January 8, 2007. 

Anna Snouffer, 

Acting Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 07–98 Filed 1–11–07; 8:45 am] 

BILLING CODE 4140–01–M 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Institute of Environmental 

Health Sciences; Notice of Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. Appendix 2) notice 

is hereby given of a meeting of the 

National Advisory Environmental 

Health Sciences Council. 

The meeting will be open to the 

public as indicated below, with 

attendance limited to space available. 

Individuals who plan to attend and 

need special assistance, such as sign 

language interpretation or other 

reasonable accommodations, should 

notify the Contact Person listed below 

in advance of the meeting. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Advisory 

Environmental Health Sciences Council. 

Date: February 15, 2007. 

Open: 8:30 a.m. to 1 p.m. 

Agenda: Discussion of program policies 

and issues. 

Place: Nat. Inst. of Environmental Health 

Sciences, Building 101, Rodbell Auditorium, 

111 T.W. Alexander Drive, Research Triangle 

Park, NC 27709. 

Closed: 1 p.m. to 2:30 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: Nat. Inst. of Environmental Health 

Sciences, Building 101, Rodbell Auditorium, 

111 T.W. Alexander Drive, Research Triangle 

Park, NC 27709. 

Open: 2:30 p.m. to 5 p.m. 

Agenda: Discussion of program policies 

and issues. 

Place: Nat. Inst. of Environmental Health 

Sciences, Building 101, Rodbell Auditorium, 

111 T.W. Alexander Drive, Research Triangle 

Park, NC 27709. 


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