[Federal Register Volume 72, Number 37 (Monday, February 26, 2007)]
[Notices]
[Pages 8391-8392]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: E7-3153]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health


Prospective Grant of Exclusive License: Use of Recombinant Yeast 
Expressing CEA for the Prevention and Treatment of Cancer

AGENCY: National Institutes of Health, Public Health Service, HHS.

ACTION: Notice.

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SUMMARY: This is notice, in accordance with 35 U.S.C. 209(c)(1) and 37 
CFR Part 404.7(a)(1)(i), that the National Institutes of Health, 
Department of Health and Human Services, is contemplating the grant of 
an exclusive

[[Page 8392]]

patent license to practice the inventions embodied in U.S. Patent 
6,756,038 and PCT Application Serial No. PCT/US98/19794 and foreign 
equivalents thereof, entitled ``Agonist and Antagonist Peptides of 
Carcinoembryonic Antigen (CEA)'' (E-099-1996/0) and U.S. Patent 
6,969,582 and PCT Application Serial No. PCT/US99/26866 and foreign 
equivalents thereof, entitled ``A Recombinant Vector Expressing 
Multiple Costimulatory Molecules and Uses Thereof'' (E-256-1998/0), to 
GlobeImmune Inc., which is located in Louisville, Colorado. The patent 
rights in these inventions have been assigned to the United States of 
America. The prospective exclusive license territory may be worldwide 
and the field of use may be limited to the use recombinant 
Saccharomyces cerevisiae expressing CEA for the prevention and 
treatment of cancer.

DATES: Only written comments and/or applications for a license which 
are received by the NIH Office of Technology Transfer on or before 
April 27, 2007 will be considered.

ADDRESSES: Requests for copies of the patent application, inquiries, 
comments, and other materials relating to the contemplated exclusive 
license should be directed to: Michelle A. Booden, PhD., Technology 
Licensing Specialist, Office of Technology Transfer, National 
Institutes of Health, 6011 Executive Boulevard, Suite 325, Rockville, 
MD 20852-3804; Telephone: (301) 451-7337; Facsimile: (301) 402-0220; E-
mail: <a href="/cdn-cgi/l/email-protection#0b6964646f6e65664b666a626725656263256c647d"><span class="__cf_email__" data-cfemail="6a0805050e0f04072a070b030644040302440d051c">[email protected]</span></a>.

SUPPLEMENTARY INFORMATION: The technology describes the composition and 
use of nucleic acid sequences that encode agonist and one antagonist 
peptide variants of the human carcinoembryonic antigen (CEA) peptide, 
including but not limited to CAP-1. CEA is an antigen, which is 
expressed on the surface of various types of cancer cells. It is 
capable of stimulating a specific cytolytic T cell response, as is CAP-
1, which is a highly immunogenic epitope of CEA. Therefore, CAP-1 
agonists which are capable of eliciting a CEA-specific cytolytic T cell 
response, such as those identified by the inventors, may represent 
potential immunogens for use as therapeutic agents or vaccines against 
various cancers, and possibly also for use against autoimmune diseases. 
In fact, at least one of the agonist peptides appears to be more 
immunogenic than the native CAP-1 peptide. CAP-1 antagonists which are 
capable of reducing or eliminating this T cell response, such as the 
antagonist peptide variant identified by the inventors, may represent 
potential agents for use against autoimmune responses to CEA or to 
agonist peptide variants thereof.
    The prospective exclusive license will be royalty bearing and will 
comply with the terms and conditions of 35 U.S.C. 209 and 37 CFR Part 
404.7. The prospective exclusive license may be granted unless within 
sixty (60) days from the date of this published notice, the NIH 
receives written evidence and argument that establishes that the grant 
of the license would not be consistent with the requirements of 35 
U.S.C. 209 and 37 CFR Part 404.7.
    Applications for a license in the field of use filed in response to 
this notice will be treated as objections to the grant of the 
contemplated exclusive license. Comments and objections submitted to 
this notice will not be made available for public inspection and, to 
the extent permitted by law, will not be released under the Freedom of 
Information Act, 5 U.S.C. 552.

    Dated: February 16, 2007.
Steven M. Ferguson,
Director, Division of Technology Development and Transfer, Office of 
Technology Transfer, National Institutes of Health.
 [FR Doc. E7-3153 Filed 2-23-07; 8:45 am]
BILLING CODE 4140-01-P


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