EX-4.5




 Exhibit 4.5 

DESCRIPTION OF SECURITIES 

REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 

As of December 31, 2020, the registrant had the following series of securities registered pursuant to Section 12 of the U.S. Securities Exchange Act
of 1934, as amended: 
  

					
	 Title of each class:
	  	 	  	 Name of each exchange on which registered:

	American Depositary Shares, each representing 1 Ordinary Share, par value $0.00006 per share	  	ZLAB	  	The Nasdaq Global Market
	Ordinary Shares, par value $0.00006 per share*	  	9688	  	The Stock Exchange of Hong Kong Limited

  

	*	 Included in connection with the registration of the American Depositary Shares with the Securities and Exchange
Commission. The ordinary shares are not registered or listed for trading in the United States but are listed for trading on The Stock Exchange of Hong Kong Limited. 



Citibank, N.A. acts as the depositary bank for the American Depositary Shares pursuant to the Deposit Agreement, dated as of September 20, 2017.
Citibank’s depositary offices are located at 388 Greenwich Street, 23rd Floor, New York, New York 10013. American Depositary Shares are frequently referred to as “ADSs” and represent ownership interests in securities that are on
deposit with the depositary bank. ADSs may be represented by certificates that are commonly known as “American Depositary Receipts” or “ADRs.” The depositary bank has appointed a custodian to safekeep the securities on deposit.
In this case, the custodian is Citibank, N.A.—Hong Kong, located at 9/F., Citi Tower, One Bay East, 83 Hoi Bun Road, Kwun Tong, Kowloon, Hong Kong. 

As of February 15, 2021, our authorized share capital consists of $30,000.00 divided into 500,000,000 ordinary shares, with a par value of $0.00006 each.

 Each American depositary share (“ADS”) represents the right to receive, and to exercise the beneficial ownership interests in, one ordinary
share that is on deposit with the depositary bank and/or custodian. An ADS also represents the right to receive, and to exercise the beneficial interests in, any other property received by the depositary bank or the custodian on behalf of the owner
of the ADS but that has not been distributed to the owners of ADSs because of legal restrictions or practical considerations. We and the depositary bank may agree to change
the ADS-to-share ratio by amending the deposit agreement. This amendment may give rise to, or change, the depositary fees payable by ADS owners. The custodian,
the depositary bank and their respective nominees will hold all deposited property for the benefit of the holders and beneficial owners of ADSs. The deposited property does not constitute the proprietary assets of the depositary bank, the custodian
or their nominees. Beneficial ownership in the deposited property will under the terms of the deposit agreement be vested in the beneficial owners of the ADSs. The depositary bank, the custodian and their respective nominees will be the record
holders of the deposited property represented by the ADSs for the benefit of the holders and beneficial owners of the corresponding ADSs. A beneficial owner of ADSs may or may not be the holder of ADSs. Beneficial owners of ADSs will be able to
receive, and to exercise beneficial ownership interests in, the deposited property only through the registered holders of the ADSs, the registered holders of the ADSs (on behalf of the applicable ADS owners) only through the depositary bank, and the
depositary bank (on behalf of the owners of the corresponding ADSs) directly, or indirectly, through the custodian or their respective nominees, in each case upon the terms of the deposit agreement. 

An ADS holder will become a party to the deposit agreement and therefore will be bound to its terms and to the terms of any ADR that represents such ADSs. The
deposit agreement and the ADR specify our rights and obligations as well as ADS holders’ rights and obligations as owner of ADSs and those of the depositary bank. ADS holders appoint the depositary bank to act on their behalf in certain
circumstances. The deposit agreement and the ADRs are governed by New York law. However, our obligations to the holders of ordinary shares will continue to be governed by the laws of the Cayman Islands, which may be different from the laws in the
United States. 











 In addition, applicable laws and regulations may require ADS holders to satisfy reporting requirements and
obtain regulatory approvals in certain circumstances. ADS holders are solely responsible for complying with such reporting requirements and obtaining such approvals. Neither the depositary bank, the custodian, us or any of their or our respective
agents or affiliates shall be required to take any actions whatsoever on ADS holders’ behalf to satisfy such reporting requirements or obtain such regulatory approvals under applicable laws and regulations. 

We will not treat ADS holders as our shareholders and ADS holders will not have direct shareholder rights. The depositary bank will hold on ADS holders’
behalf the shareholder rights attached to the ordinary shares underlying the ADSs. ADS holders will be able to exercise the shareholders rights for the ordinary shares represented by the ADSs through the depositary bank only to the extent
contemplated in the deposit agreement. To exercise any shareholder rights not contemplated in the deposit agreement, an ADS holder will, as an ADS owner, need to arrange for the cancellation of such ADSs and become a direct shareholder. 

The manner in which ADS holders owns the ADSs (e.g., in a brokerage account vs. as registered holder, or as holder of certificated vs. uncertificated ADSs)
may affect the holders’ rights and obligations, and the manner in which, and extent to which, the depositary bank’s services are made available to the holders. An ADS holder may hold the ADSs either by means of an ADR registered in such
holder’s name, through a brokerage or safekeeping account, or through an account established by the depositary bank in such holder’s name reflecting the registration of uncertificated ADSs directly on the books of the depositary bank
(commonly referred to as the “direct registration system” or “DRS”). The direct registration system reflects the uncertificated (book-entry) registration of ownership of ADSs by the depositary bank. Under the direct registration
system, ownership of ADSs is evidenced by periodic statements issued by the depositary bank to the holders of the ADSs. The direct registration system includes automated transfers between the depositary bank and The Depository Trust Company
(“DTC”), the central book-entry clearing and settlement system for equity securities in the United States. If an ADS holder decides to hold the ADSs through such holder’s brokerage or safekeeping account, the holder must rely on the
procedures of his/her broker or bank to assert his/her rights as an ADS owner. Banks and brokers typically hold securities such as the ADSs through clearing and settlement systems such as DTC. The procedures of such clearing and settlement systems
may limit an ADS holder’s ability to exercise such holder’s rights as an owner of ADSs. ADS holders should consult with their broker or bank if they have any questions concerning these limitations and procedures. All ADSs held through DTC
will be registered in the name of a nominee of DTC. This summary description assumes ADS holders have opted to own the ADSs directly by means of ADSs registered in such holders’ name and, as such, we will refer to ADS holders as the
“holders.” 
 The registration of the ordinary shares in the name of the depositary bank or the custodian shall, to the maximum extent permitted
by applicable law, vest in the depositary bank or the custodian the record ownership in the applicable ordinary shares with the beneficial ownership rights and interests in such ordinary shares being at all times vested with the beneficial owners of
the ADSs representing the ordinary shares. The depositary bank or the custodian shall at all times be entitled to exercise the beneficial ownership rights in all deposited property, in each case only on behalf of the holders and beneficial owners of
the ADSs representing the deposited property. 
 Dividends and distributions 

Holders of ADSs generally have the right to receive the distributions we make on the securities deposited with the custodian. ADS holders’ receipt of
these distributions may be limited, however, by practical considerations and legal limitations. Holders of ADSs will receive such distributions under the terms of the deposit agreement in proportion to the number of ADSs held as of the specified
record date, after deduction of the applicable fees, taxes and expenses. 
 Distributions of cash 

Whenever we make a cash distribution for the securities on deposit with the custodian, we will deposit the funds with the custodian. Upon receipt of
confirmation of the deposit of the requisite funds, the depositary bank will arrange for the funds received in a currency other than U.S. dollars to be converted into U.S. dollars and for the distribution of the U.S. dollars to the holders, subject
to Cayman Islands laws and regulations. 











 The conversion into U.S. dollars will take place only if practicable and if the U.S. dollars are
transferable to the United States. The depositary bank will apply the same method for distributing the proceeds of the sale of any property (such as undistributed rights) held by the custodian in respect of securities on deposit. 

The distribution of cash will be made net of the fees, expenses, taxes and governmental charges payable by holders under the terms of the deposit agreement.
The depositary bank will hold any cash amounts it is unable to distribute in a non-interest bearing account for the benefit of the applicable holders and beneficial owners of ADSs until the
distribution can be effected or the funds that the depositary bank holds must be escheated as unclaimed property in accordance with the laws of the relevant states of the United States. 

Distributions of shares 
 Whenever we make a free
distribution of ordinary shares for the securities on deposit with the custodian, we will deposit the applicable number of ordinary shares with the custodian. Upon receipt of confirmation of such deposit, the depositary bank will either distribute
to holders new ADSs representing the ordinary shares deposited or modify the ADS-to-ordinary share ratio, in which case each ADS holders hold will represent
rights and interests in the additional ordinary shares so deposited. Only whole new ADSs will be distributed. Fractional entitlements will be sold and the proceeds of such sale will be distributed as in the case of a cash distribution. 

The distribution of new ADSs or the modification of
the ADS-to-ordinary share ratio upon a distribution of ordinary shares will be made net of the fees, expenses, taxes and governmental charges payable by
holders under the terms of the deposit agreement. In order to pay such taxes or governmental charges, the depositary bank may sell all or a portion of the new ordinary shares so distributed. 

No such distribution of new ADSs will be made if it would violate a law (e.g., the U.S. securities laws) or if it is not operationally practicable. If the
depositary bank does not distribute new ADSs as described above, it may sell the ordinary shares received upon the terms described in the deposit agreement and will distribute the proceeds of the sale as in the case of a distribution of cash. 

Distributions of rights 
 Whenever we intend to distribute
rights to subscribe for additional ordinary shares, we will give prior notice to the depositary bank and we will assist the depositary bank in determining whether it is lawful and reasonably practicable to distribute rights to subscribe for
additional ADSs to holders. 
 The depositary bank will establish procedures to distribute rights to subscribe for additional ADSs to holders and to enable
such holders to exercise such rights if it is lawful and reasonably practicable to make the rights available to holders of ADSs, and if we provide all of the documentation contemplated in the deposit agreement (such as opinions to address the
lawfulness of the transaction). Holders may have to pay fees, expenses, taxes and other governmental charges to subscribe for the new ADSs upon the exercise of such rights. The depositary bank is not obligated to establish procedures to facilitate
the distribution and exercise by holders of rights to subscribe for new ordinary shares other than in the form of ADSs. 
 The depositary bank will not
distribute the rights to holders if: 
  

	
	 •   We do not timely request that the rights be distributed to holders
or we request that the rights not be distributed to holders; or

	
	 •   We fail to deliver satisfactory documents to the depositary bank;
or

	
	 •   It is not reasonably practicable to distribute the
rights.


 The depositary bank will sell the rights that are not exercised or not distributed if such sale is lawful and reasonably
practicable. The proceeds of such sale will be distributed to holders as in the case of a cash distribution. If the depositary bank is unable to sell the rights, it will allow the rights to lapse. 











 Elective distributions 

Whenever we intend to distribute a dividend payable at the election of shareholders either in cash or in additional shares, we will give prior notice thereof
to the depositary bank and will indicate whether we wish the elective distribution to be made available to holders. In such case, we will assist the depositary bank in determining whether such distribution is lawful and reasonably practicable. 

The depositary bank will make the election available to holders only if it is reasonably practicable and if we have provided all of the documentation
contemplated in the deposit agreement. In such case, the depositary bank will establish procedures to enable holders to elect to receive either cash or additional ADSs, in each case as described in the deposit agreement. 

If the election is not made available to holders, holders will receive either cash or additional ADSs, depending on what a shareholder in the Cayman Islands
would receive upon failing to make an election, as more fully described in the deposit agreement. 
 Other distributions 

Whenever we intend to distribute property other than cash, ordinary shares or rights to subscribe for additional ordinary shares, we will notify the depositary
bank in advance and will indicate whether we wish such distribution to be made to holders. If so, we will assist the depositary bank in determining whether such distribution to holders is lawful and reasonably practicable. 

If it is reasonably practicable to distribute such property to holders and if we provide to the depositary bank all of the documentation contemplated in the
deposit agreement, the depositary bank will distribute the property to holders in a manner it deems practicable. 
 The distribution will be made net of
fees, expenses, taxes and governmental charges payable by holders under the terms of the deposit agreement. In order to pay such taxes and governmental charges, the depositary bank may sell all or a portion of the property received. 

The depositary bank will not distribute the property to holders and will sell the property if: 

 

	•	 We do not request that the property be distributed to holders or if we request that the property not be
distributed to holders; or 


  

	•	 We do not deliver satisfactory documents to the depositary bank; or 



 

	•	 The depositary bank determines that all or a portion of the distribution to holders is not reasonably
practicable; or 


  

	•	 The proceeds of such a sale will be distributed to holders as in the case of a cash distribution.



 Redemption 
 Whenever we decide to
redeem any of the securities on deposit with the custodian, we will notify the depositary bank in advance. If it is practicable and if we provide all of the documentation contemplated in the deposit agreement, the depositary bank will provide notice
of the redemption to holders. 
 The custodian will be instructed to surrender the shares being redeemed against payment of the applicable redemption price.
The depositary bank will convert into U.S. dollars upon the terms of the deposit agreement the redemption funds received in a currency other than U.S. dollars and will establish procedures to enable holders to receive the net proceeds from the
redemption upon surrender of their ADSs to the depositary bank. Holders may have to pay fees, expenses, taxes and other governmental charges upon the redemption of the ADSs. If less than all ADSs are being redeemed, the ADSs to be retired will be
selected by lot or on a pro rata basis, as the depositary bank may determine. 











 Changes affecting ordinary shares 

The ordinary shares held on deposit for the ADSs may change from time to time. For example, there may be a change in nominal or par value, split-up, cancellation, consolidation or any other reclassification of such ordinary shares or a recapitalization, reorganization, merger, consolidation or sale of assets of the Company. 

If any such change were to occur, the ADSs would, to the extent permitted by law and the deposit agreement, represent the right to receive the property
received or exchanged in respect of the ordinary shares held on deposit. The depositary bank may in such circumstances deliver new ADSs to holders, amend the deposit agreement, the ADRs and the applicable Registration Statement(s) on Form F-6, call for the exchange of holders’ existing ADSs for new ADSs and take any other actions that are appropriate to reflect as to the ADSs the change affecting the ordinary shares. If the
depositary bank may not lawfully distribute such property to holders, the depositary bank may sell such property and distribute the net proceeds to holders as in the case of a cash distribution. 

Issuance of ADSs upon deposit of ordinary shares 
 Our
ordinary shares have been and will be deposited with the custodian. The depositary bank may create ADSs on a holder’s behalf if such holder or such holder’s broker deposits ordinary shares with the custodian. The depositary bank will
deliver these ADSs to the person such holder indicates only after such holder pays any applicable issuance fees and any charges and taxes payable for the transfer of the ordinary shares to the custodian. Holders’ ability to deposit ordinary
shares and receive ADSs may be limited by U.S. and Cayman Islands legal considerations applicable at the time of deposit. 
 The issuance of ADSs may be
delayed until the depositary bank or the custodian receives confirmation that all required approvals have been given and that the ordinary shares have been duly transferred to the custodian. The depositary bank will only issue ADSs in whole numbers.

 When a holder makes a deposit of ordinary shares, such holder will be responsible for transferring good and valid title to the depositary bank. As such,
the holder will be deemed to represent and warrant that: 
  

	 	•	 	 The ordinary shares are duly authorized, validly issued, fully
paid, non-assessable and legally obtained. 


  

	 	•	 	 All preemptive (and similar) rights, if any, with respect to such ordinary shares have been validly waived or
exercised. 


  

	 	•	 	 The holder is duly authorized to deposit the ordinary shares. 



 

	 	•	 	 The ordinary shares presented for deposit are free and clear of any lien, encumbrance, security interest, charge,
mortgage or adverse claim, and are not, and the ADSs issuable upon such deposit will not be, “restricted securities” (as defined in the deposit agreement). 



 

	 	•	 	 The ordinary shares presented for deposit have not been stripped of any rights or entitlements.



 If any of the representations or warranties are incorrect in any way, we and the depositary bank may, at holders’ cost and
expense, take any and all actions necessary to correct the consequences of the misrepresentations. 
 Transfer, combination and split up of ADRs 

Holders will be entitled to transfer, combine or split up their ADRs and the ADSs evidenced thereby. For transfers of ADRs, a holder will have to surrender the
ADRs to be transferred to the depositary bank and also must: 
  

	 	•	 	 ensure that the surrendered ADR is properly endorsed or otherwise in proper form for transfer;



  

	 	•	 	 provide such proof of identity and genuineness of signatures as the depositary bank deems appropriate;



  

	 	•	 	 provide any transfer stamps required by the State of New York or the United States; and 



 

	 	•	 	 pay all applicable fees, charges, expenses, taxes and other government charges payable by ADR holders pursuant to
the terms of the deposit agreement, upon the transfer of ADRs. 













 To have the ADRs either combined or split up, a holder must surrender his/her ADRs in question to the
depositary bank with such holder’s request to have them combined or split up, and such holder must pay all applicable fees, charges and expenses payable by ADR holders, pursuant to the terms of the deposit agreement, upon a combination or split
up of ADRs. 
 Withdrawal of ordinary shares upon cancellation of ADSs 

Holders will be entitled to present their ADSs to the depositary bank for cancellation and then receive the corresponding number of underlying ordinary shares
at the custodian’s offices. Holders’ ability to withdraw the ordinary shares held in respect of the ADSs may be limited by U.S. and Cayman Islands considerations applicable at the time of withdrawal. In order to withdraw the ordinary
shares represented by the ADSs, holders will be required to pay to the depositary bank the fees for cancellation of ADSs and any charges and taxes payable upon the transfer of the ordinary shares. Holders assume the risk for delivery of all funds
and securities upon withdrawal. Once canceled, the ADSs will not have any rights under the deposit agreement. 
 If a holder holds ADSs registered in
his/her name, the depositary bank may ask such holder to provide proof of identity and genuineness of any signature and such other documents as the depositary bank may deem appropriate before it will cancel the ADSs. The withdrawal of the ordinary
shares represented by the ADSs may be delayed until the depositary bank receives satisfactory evidence of compliance with all applicable laws and regulations. Please keep in mind that the depositary bank will only accept ADSs for cancellation that
represent a whole number of securities on deposit. 
 Holders will have the right to withdraw the securities represented by the ADSs at any time except for:

  

	 	•	 Temporary delays that may arise because (i) the transfer books for the ordinary shares or ADSs are closed,
or (ii) ordinary shares are immobilized on account of a shareholders’ meeting or a payment of dividends. 


  

	 	•	 Obligations to pay fees, taxes and similar charges. 



 

	 	•	 Restrictions imposed because of laws or regulations applicable to ADSs or the withdrawal of securities on
deposit. 


  

	 	•	 The deposit agreement may not be modified to impair holders’ right to withdraw the securities represented
by the ADSs except to comply with mandatory provisions of law. 


 Voting rights 

Holders generally have the right under the deposit agreement to instruct the depositary bank to exercise the voting rights for the ordinary shares represented
by ADSs. 
 At our request, the depositary bank will distribute to holders any notice of shareholders’ meeting received from us together with
information explaining how to instruct the depositary bank to exercise the voting rights of the securities represented by ADSs. 
 If the depositary bank
timely receives voting instructions from a holder, it will endeavor to vote the securities (in person or by proxy) represented by the holder’s ADSs in accordance with such voting instructions as follows: 

 

	 	•	 In the event of voting by show of hands, the depositary bank will vote (or cause the custodian to vote)
all ordinary shares held on deposit at that time in accordance with the voting instructions received from a majority of holders who provide timely voting instructions. 



 

	 	•	 In the event of voting by poll, the depositary bank will vote (or cause the Custodian to vote) the ordinary
shares held on deposit in accordance with the voting instructions received from the holders. 













 In the event of voting by poll, holders in respect of which no timely voting instructions have been received
shall be deemed to have instructed the depositary bank to give a discretionary proxy to a person designated by us to vote the ordinary shares represented by such holders’ ADSs; provided, that no such instructions shall be deemed given and no
such discretionary proxy shall be given with respect to any matter as to which we inform the depositary bank that we do not wish such proxy to be given; provided, further, that no such discretionary proxy shall be given (x) with respect to any
matter as to which we inform the depositary that (i) there exists substantial opposition, or (ii) the rights of holders or the shareholders of our company will be materially adversely affected, and (y) in the event that the vote is on
a show of hands. 
 Please note that the ability of the depositary bank to carry out voting instructions may be limited by practical and legal limitations
and the terms of the securities on deposit. We cannot assure that holders will receive voting materials in time to enable them to return voting instructions to the depositary bank in a timely manner. 

Fees and charges 
 Holders will be required to pay the
following fees under the terms of the deposit agreement:
  

			
	 Service
	  	 Fees

	 •  Issuance of ADSs (e.g., an issuance of ADS upon a deposit of ordinary shares,
upon a change in the ADS(s)-to-share ratio, or for any other reason), excluding ADS issuances as a result of distributions of ordinary shares
	  	Up to U.S. 5¢ per ADS issued
	 •  Cancellation of ADSs (e.g., a cancellation of ADSs for delivery of deposited
property, upon a change in the ADS(s)-to-share ratio, or for any other reason)
	  	Up to U.S. 5¢ per ADS cancelled
	 •  Distribution of cash dividends or other cash distributions (e.g., upon a sale
of rights and other entitlements)
	  	Up to U.S. 5¢ per ADS held
	 •  Distribution of ADSs pursuant to (i) stock dividends or other free stock
distributions, or (ii) exercise of rights to purchase additional ADSs
	  	Up to U.S. 5¢ per ADS held
	 •  Distribution of securities other than ADSs or rights to purchase additional
ADSs (e.g., upon a spin-off)
	  	Up to U.S. 5¢ per ADS held
	 •  ADS Services
	  	Up to U.S. 5¢ per ADS held on the applicable record date(s) established by the depositary bank

 Holders will also be responsible to pay certain charges such as: 

 

	 	•	 taxes (including applicable interest and penalties) and other governmental charges; 



 

	 	•	 the registration fees as may from time to time be in effect for the registration of ordinary shares on the
share register and applicable to transfers of ordinary shares to or from the name of the custodian, the depositary bank or any nominees upon the making of deposits and withdrawals, respectively; 



 

	 	•	 certain cable, telex and facsimile transmission and delivery expenses; 



 

	 	•	 the expenses and charges incurred by the depositary bank in the conversion of foreign currency;



  

	 	•	 the fees and expenses incurred by the depositary bank in connection with compliance with exchange control
regulations and other regulatory requirements applicable to ordinary shares, ADSs and ADRs; and 


  

	 	•	 the fees and expenses incurred by the depositary bank, the custodian, or any nominee in connection with the
servicing or delivery of deposited property. 













 ADS fees and charges payable upon (i) the issuance of ADSs, and (ii) the cancellation of ADSs are
charged to the person to whom the ADSs are issued (in the case of ADS issuances) and to the person whose ADSs are cancelled (in the case of ADS cancellations). In the case of ADSs issued by the depositary bank into DTC, the ADS issuance and
cancellation fees and charges may be deducted from distributions made through DTC, and may be charged to the DTC participant(s) receiving the ADSs being issued or the DTC participant(s) holding the ADSs being cancelled, as the case may be, on behalf
of the beneficial owner(s) and will be charged by the DTC participant(s) to the account of the applicable beneficial owner(s) in accordance with the procedures and practices of the DTC participants as in effect at the time. ADS fees and charges in
respect of distributions and the ADS service fee are charged to the holders as of the applicable ADS record date. In the case of distributions of cash, the amount of the applicable ADS fees and charges is deducted from the funds being distributed.
In the case of (i) distributions other than cash and (ii) the ADS service fee, holders as of the ADS record date will be invoiced for the amount of the ADS fees and charges and such ADS fees and charges may be deducted from distributions
made to holders of ADSs. For ADSs held through DTC, the ADS fees and charges for distributions other than cash and the ADS service fee may be deducted from distributions made through DTC, and may be charged to the DTC participants in accordance with
the procedures and practices prescribed by DTC and the DTC participants in turn charge the amount of such ADS fees and charges to the beneficial owners for whom they hold ADSs. 

In the event of refusal to pay the depositary bank fees, the depositary bank may, under the terms of the deposit agreement, refuse the requested service until
payment is received or may set off the amount of the depositary bank fees from any distribution to be made to holders. Certain of the depositary fees and charges (such as the ADS services fee) may become payable shortly after the closing of an ADS
offering. Note that the fees and charges holders may be required to pay may vary over time and may be changed by us and by the depositary bank. Holders will receive prior notice of such changes. The depositary bank may reimburse us for certain
expenses incurred by us in respect of the ADR program, by making available a portion of the ADS fees charged in respect of the ADR program or otherwise, upon such terms and conditions as we and the depositary bank agree from time to time. 

Amendments and termination 
 We may agree with the
depositary bank to modify the deposit agreement at any time without holders’ consent. We undertake to give holders 30 days’ prior notice of any modifications that would materially prejudice any of their substantial rights under the deposit
agreement. We will not consider to be materially prejudicial to holders’ substantial rights any modifications or supplements that are reasonably necessary for the ADSs to be registered under the Securities Act or to be eligible for book-entry
settlement, in each case without imposing or increasing the fees and charges holders are required to pay. In addition, we may not be able to provide holders with prior notice of any modifications or supplements that are required to accommodate
compliance with applicable provisions of law. 
 Holders will be bound by the modifications to the deposit agreement if they continue to hold their ADSs
after the modifications to the deposit agreement become effective. The deposit agreement cannot be amended to prevent holders from withdrawing the ordinary shares represented by the ADSs (except as permitted by law). 

We have the right to direct the depositary bank to terminate the deposit agreement. Similarly, the depositary bank may in certain circumstances on its own
initiative terminate the deposit agreement. In either case, the depositary bank must give notice to holders at least 30 days before termination. Until termination, holders’ rights under the deposit agreement will be unaffected. 

After termination, the depositary bank will continue to collect distributions received (but will not distribute any such property until holders request the
cancellation of their ADSs) and may sell the securities held on deposit. 
 After the sale, the depositary bank will hold the proceeds from such sale and
any other funds then held for the holders of ADSs in a non-interest bearing account. At that point, the depositary bank will have no further obligations to holders other than to account for the funds
then held for the holders of ADSs still outstanding (after deduction of applicable fees, taxes and expenses). 
 Books of depositary 

The depositary bank will maintain ADS holder records at its depositary office. Holders may inspect such records at such office during regular business hours
but solely for the purpose of communicating with other holders in the interest of business matters relating to the ADSs and the deposit agreement. 











 The depositary bank will maintain in New York facilities to record and process the issuance, cancellation, combination, split-up and transfer of ADSs. These facilities may be closed from time to time, to the extent not prohibited by law. 

Limitations on obligations and liabilities 
 The deposit
agreement limits our obligations and the depositary bank’s obligations to holders. Please note the following: 
  

	 	•	 we and the depositary bank are obligated only to take the actions specifically stated in the deposit agreement
without negligence or bad faith. 


  

	 	•	 the depositary bank disclaims any liability for any failure to carry out voting instructions, for any manner in
which a vote is cast or for the effect of any vote, provided it acts in good faith and in accordance with the terms of the deposit agreement. 


  

	 	•	 the depositary bank disclaims any liability for any failure to determine the lawfulness or practicality of any
action, for the content of any document forwarded to holders on our behalf or for the accuracy of any translation of such a document, for the investment risks associated with investing in ordinary shares, for the validity or worth of the ordinary
shares, for any tax consequences that result from the ownership of ADSs, for the credit-worthiness of any third party, for allowing any rights to lapse under the terms of the deposit agreement, for the timeliness of any of our notices or for our
failure to give notice. 


  

	 	•	 we and the depositary bank will not be obligated to perform any act that is inconsistent with the terms of the
deposit agreement. 


  

	 	•	 we and the depositary bank disclaim any liability if we or the depositary bank, or our respective controlling
persons or agents are prevented or forbidden from, or subject to any civil or criminal penalty or restraint on account of, or delayed in, doing or performing any act or thing required by the terms of the deposit agreement, by reason of any
provision, present or future of any law or regulation, or by reason of present or future provision of any provision of our articles of association, or any provision of or governing the securities on deposit, or by reason of any act of God or war or
other circumstances beyond our control. 


  

	 	•	 we and the depositary bank disclaim any liability by reason of any exercise of, or failure to exercise, any
discretion provided for in the deposit agreement or in our articles of association or in any provisions of or governing the securities on deposit. 


  

	 	•	 we and the depositary bank further disclaim any liability for any action or inaction in reliance on the advice
or information received from legal counsel, accountants, any person presenting ordinary shares for deposit, any holder or authorized representatives thereof, or any other person believed by either of us in good faith to be competent to give such
advice or information. 


  

	 	•	 we and the depositary bank also disclaim liability for the inability by a holder to benefit from any
distribution, offering, right or other benefit that is made available to holders of ordinary shares but is not, under the terms of the deposit agreement, made available to holders. 



 

	 	•	 we and the depositary bank may rely without any liability upon any written notice, request or other document
believed to be genuine and to have been signed or presented by the proper parties. 


  

	 	•	 we and the depositary bank also disclaim liability for any consequential, indirect or punitive damages for any
breach of the terms of the deposit agreement, or otherwise. 


  

	 	•	 no disclaimer of any Securities Act liability is intended by any provision of the deposit agreement.



  

	 	•	 nothing in the deposit agreement gives rise to a partnership or joint venture, or establishes a fiduciary
relationship, among us, the depositary bank and holders. 














	 	•	 nothing in the deposit agreement precludes Citibank (or its affiliates) from engaging in transactions in which
parties adverse to us or the ADS owners have interests, and nothing in the deposit agreement obligates Citibank to disclose those transactions, or any information obtained in the course of those transactions, to us or to the ADS owners, or to
account for any payment received as part of those transactions. 



Pre-release transactions 

Subject to the terms and conditions of the deposit agreement, the depositary bank may issue to broker/dealers ADSs before receiving a deposit of ordinary
shares or release ordinary shares to broker/dealers before receiving ADSs for cancellation. These transactions are commonly referred to as “pre-release transactions,” and are entered into
between the depositary bank and the applicable broker/dealer. The deposit agreement limits the aggregate size of pre-release transactions (not to exceed 30% of the ordinary shares on deposit in the
aggregate) and imposes a number of conditions on such transactions (e.g., the need to receive collateral, the type of collateral required, the representations required from brokers, etc.). The depositary bank may retain the compensation received
from the pre-release transactions. 
 Taxes 

Holders will be responsible for the taxes and other governmental charges payable on the ADSs and the securities represented by the ADSs. We, the depositary
bank and the custodian may deduct from any distribution the taxes and governmental charges payable by holders and may sell any and all property on deposit to pay the taxes and governmental charges payable by holders. Holders will be liable for any
deficiency if the sale proceeds do not cover the taxes that are due. 
 The depositary bank may refuse to issue ADSs, to deliver, transfer, split and
combine ADRs or to release securities on deposit until all taxes and charges are paid by the applicable holder. The depositary bank and the custodian may take reasonable administrative actions to obtain tax refunds and reduced tax withholding for
any distributions on holders’ behalf. However, holders may be required to provide to the depositary bank and to the custodian proof of taxpayer status and residence and such other information as the depositary bank and the custodian may require
to fulfill legal obligations. Holders are required to indemnify us, the depositary bank and the custodian for any claims with respect to taxes arising out of any refund of taxes, reduced rate of withholding or of the tax benefit obtained for or by
the holders. 
 Foreign currency conversion 
 The
depositary bank will arrange for the conversion of all foreign currency received into U.S. dollars if such conversion is practical, and it will distribute the U.S. dollars in accordance with the terms of the deposit agreement. Holder may have
to pay fees and expenses incurred in converting foreign currency, such as fees and expenses incurred in complying with currency exchange controls and other governmental requirements. 

If the conversion of foreign currency is not practical or lawful, or if any required approvals are denied or not obtainable at a reasonable cost or within a
reasonable period, the depositary bank may take the following actions in its discretion: 
  

	•	 Convert the foreign currency to the extent practical and lawful and distribute the U.S. dollars to holders for
whom the conversion and distribution is lawful and practical. 


  

	•	 Distribute the foreign currency to holders for whom the distribution is lawful and practical.



  

	•	 Hold the foreign currency (without liability for interest) for the applicable holders. 



Governing law/waiver of jury trial 
 The deposit
agreement and the ADRs will be interpreted in accordance with the laws of the State of New York. The rights of holders of ordinary shares (including ordinary shares represented by ADSs) is governed by the laws of the Cayman Islands. 











 By holding an ADS or an interest therein, ADS holders irrevocably agree that any legal suit, action or
proceeding against or involving us or the Depositary, arising out of or based upon the deposit agreement, ADSs or ADRs, may only be instituted in a state or federal court in New York, New York, and ADS holders irrevocably waive any objection to the
laying of venue and irrevocably submit to the exclusive jurisdiction of such courts with respect to any such suit, action or proceeding. 
 AS A PARTY TO
THE DEPOSIT AGREEMENT, ADS HOLDERS IRREVOCABLY WAIVE THE RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF THE DEPOSIT AGREEMENT, THE ADRs AND ANY TRANSACTIONS CONTEMPLATED THEREIN (WHETHER BASED ON CONTRACT, TORT, COMMON LAW OR
OTHERWISE) AGAINST US AND/OR THE DEPOSITARY BANK.