Exhibit 10.5

   
   

  ARYA SCIENCES ACQUISITION CORP IV

      51 Astor Place, 10th Floor

      New York, New York 10003

   

  March 2, 2021

   

  ARYA Sciences Holdings IV

      c/o Perceptive Advisors

      51 Astor Place, 10th Floor

      New York, New York 10003

   

  Ladies and Gentlemen:

   

  This letter will confirm our agreement that, commencing on the effective date (the “Effective
          Date”) of the registration statement (the “Registration Statement”) for the initial public offering (the “IPO”) of the securities of ARYA Sciences Acquisition Corp IV (the “Company”) and
      continuing until the earlier of (i) the consummation by the Company of an initial business combination and (ii) the Company’s liquidation (in each case as described in the Registration Statement) (such earlier date hereinafter referred to as the “Termination
          Date”), ARYA Sciences Holdings IV (the “Sponsor”) shall take steps directly or indirectly to make available to the Company certain office space, secretarial and administrative services as may be required by the Company from
      time to time, situated at 51 Astor Place, 10th Floor, New York, New York 10003 (or any successor location). In exchange therefore, the Company shall pay the Sponsor a sum of $10,000 per month commencing on the Effective Date and continuing monthly
      thereafter until the Termination Date. The Sponsor hereby agrees that it does not have any right, title, interest or claim of any kind (a “Claim”) in or to any monies that may be set aside in a trust account (the “Trust Account”)
      that may be established in connection with and upon the consummation of the IPO and hereby irrevocably waives any Claim it presently has or may have in the future as a result of, or arising out of, any negotiations, contracts or agreements with the
      Company and will not seek recourse, reimbursement, payment or satisfaction of any Claim against the Trust Account or any monies or other assets in the Trust Account for any reason whatsoever.

   

  This letter agreement constitutes the entire agreement and understanding of the parties hereto
      in respect of its subject matter and supersedes all prior understandings, agreements, or representations by or among the parties hereto, written or oral, to the extent they relate in any way to the subject matter hereof or the transactions
      contemplated hereby.

   

  This letter agreement may not be amended, modified or waived as to any particular provision,
      except by a written instrument executed by the parties hereto.

   

  The parties may not assign this letter agreement and any of their rights, interests, or
      obligations hereunder without the consent of the other party. Any purported assignment in violation of this paragraph shall be void and ineffectual and shall not operate to transfer or assign any interest or title to the purported assignee.

   

  

  
      

    
      
 

  

  
   

  This letter agreement shall be governed by, construed in accordance with, and interpreted
      pursuant to the laws of the State of New York, without giving effect to its choice of laws principles that will apply the laws of another jurisdiction.

   

  This letter agreement may be executed in one or more counterparts, each of which shall for all
      purposes be deemed to be an original but all of which together shall constitute one and the same agreement. Only one such counterpart signed by the party against whom enforceability is sought needs to be produced to evidence the existence of this
      letter agreement.

   

  [Signature Page Follows]

   

  
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  	 	Very truly yours,
	 	 
	 	ARYA SCIENCES ACQUISITION CORP IV
	 	 	 
	 	By:	/s/ Adam Stone
	 	 	Name:   Adam Stone
	 	 	Title:     Chief Executive Officer


  

   

  

  	AGREED TO AND ACCEPTED BY:	 
	 	 
	ARYA SCIENCES HOLDINGS IV	 
	 	 	 
	By:	/s/ Adam Stone	 
	 	Name:  Adam Stone	 
	 	Title:    Authorized Signatory