Exhibit 10.22
 FIRST AMENDMENT TO LEASE  (5871 Oberlin Drive)
 First Amendment Landlord Tenant Subtenant
 R E C I T A L S:
 Original Landlord Lease Premises Building
  Sublease Premises Sublease
     Release of Tenant.
 -2-




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Recognition of Subtenant
 Lease Modifications.
 Premises.
 Tenants Pro-Rata Share.
 Basic Monthly Rent.
 Period
    
    Basic Monthly Rent|12/01/10-01/31/11
    
    $
    29,869.95




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Purchase of FF&E by Landlord. Rent Credit
 Transfer of Security Deposit.
 Release of Letter of Credit.
 Tenants Rent Payment. Rent Differential Payment
 Condition of the Premises.
 Reimbursement
 Brokers.
 Signing Authority.




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No Further Modification.
 [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]




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LANDLORD
    ARE-SD REGION NO. 31, LLC,
a Delaware limited liability companyBy:
    ALEXANDRIA REAL ESTATE EQUITIES, L.P.,a Delaware limited partnership,managing member By:
    ARE-QRS CORP.,a Maryland corporation, general partner By:
    /s/ Gary DeanIts: VP  RE Legal Affairs TENANT
    PHENOMIX CORPORATION,
a Delaware corporationBy:
    Brian BakerIts: PresidentBy:
    /s/ Brian BakerIts: PresidentSUBTENANT
    ANADYS PHARMACEUTICALS, INC.,
a Delaware corporationBy:
    /s/ Peter SloverIts: Vice President, Finance and Operations




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EXHIBIT A
 PREMISES




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EXHIBIT B  FF&E LIST
 BarCode
    
    Model No./Description
    
    Serial No.
    
    Vendor000-1255
    
    N750 Access / Intrusion Control System
    
    
    
    
    
    Northern Computer Parker000-1261
    
    9 HP Boiler steam plant & 42 HP boiler steam plant
Emergency Generator000-1235
    
    Cage & Rack Washer R630
    
    
    630-1203-N1405
    
    
    NorthWestern Systems000-1224
    
    Sterilizer SSR-3A-PB
    
    
    6045
    
    
    Laboratory Equipment000-1250
    
    RO/DI system
    
    
    
    
    
    Robert E Byrne Company000-1242
    
    Video Camera System
    
    
    
    
    
    AIS /Mitsubishi000-1225
    
    Glass washer #470
    
    
    3601894003
    
    
    Amsco000-1226
    
    Glass dryer #475
    
    
    3632493002
    
    
    Amsco000-1001/1002
    
    Phone System
    
    
    
    
    
    Siemens
 Office
    
    Office Furniture
    
    Qty203
    
    Desk
    
    
    1Side Chair  Red
    
    
    2Bookcase
    
    
    1Cabinet
    
    
    1204
    
    Desk
    
    
    1Side Chair
    
    
    4Bookcase
    
    
    1Cabinet
    
    
    1Round Table (205)
    
    
    1206
    
    Desk
    
    
    2Bookcase(207)
    
    
    2208
    
    Desk
    
    
    1Side Chair  Red
    
    
    2Round Table
    
    
    1210
    
    Desk
    
    
    1Bookcase
    
    
    1Round Table
    
    
    1211
    
    Desk
    
    
    1Side Chair
    
    
    1212
    
    Desk
    
    
    1Side Chair
    
    
    3Round Table
    
    
    1213
    
    Conference Table
    
    
    1Office Chair  Green
    
    
    1Bookcase
    
    
    2214
    
    Round Table
    
    
    1Kitchen
    
    Side Chair  Black
    
    
    3217
    
    Tech Stations
    
    
    12Tech Area
    
    Cubes
    
    
    5201
    
    Cubes
    
    
    17Open Offices