Docket Number: EPA - HQ - OPP - 200 8 - 0767

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### Table of Contents 1 Introduction ................................ ................................ ................................ ............................. 3 2 Background Information ................................ ................................ ................................ ......... 4 3 Registration Review Case Closure ................................ ................................ .......................... 4Docket Number: EPA - HQ - OPP - 200 8 - 0767

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## 1 Introduction The Food Quality Protection Act (FQPA) of 1996 mandated a registration review program. All pesticides distributed or sold in the United States generally must be registered by the U.S. Environmental Protection Agency (USEPA, EPA, or the a gency) based on sci entific data showing that they will not cause unreasonable risks to human health or the environment when used as directed on product labeling. The registration review program is intended to make sure that, as the ability to assess risk evolves and as polic ies and practices change, all registered pesticides continue to meet the statutory standard of no unreasonable adverse effects to human health or the environment. Changes in science, public policy, and pesticide use practices will occur over time. Through the registration review program, the a gency periodically reevaluates pesticides to make sure that as change occurs, products in the marketplace can be used safely. Information on this program is provided at http://www.epa.gov/oppsrrd1/registration_review/ . The a gency is implementing the registration review program pursuant to Section 3(g) of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and will review each registered pesticide every 15 years to determine whether it continues to meet the FIFRA standa rd for registration. The regulations governing registration review begin at 40 CF R 155.40. The a gency will consider benefits information and data as required by FIFRA. The public phase of registration review begins when the initial docket is opened for eac h case. The docket is the a gency ’s opportunity to state what it knows about the pesticide and what additional risk analyses and data or information it believes are needed to make a registration review decision. Pursuant to 40 CFR Part 155.50, the a gency f ormally initiated registration review for 4,5 - Dichloro - 1,2 - dithiol - 3 - one ( RYH - 86 ), c ase # 5033, in December 2008 . The following timeline highlights significant events that have occurred during the registration review of RYH - 86 :  December 1 9 , 200 8

– Publication of the 4,5 - Dichloro - 1,2 - dithiol - 3 - one ( RYH - 86 ) Summary Document , incl uding the Preliminary Work Plan, Human H ealth E ffects, S ummary of Product Chemistry, Environmental Fate, and E cotoxicity documents in the docket (EPA - HQ - OPP - 200 8 - 0767 ) for a 90 - day public comment period. The a gency received one public comment which did not affect the registration review schedule of RYH - 86 .  June 1 , 20 09

– Publication of the 4,5 - Dichloro - 1,2 - dithiol - 3 - one (RYH - 86) Final Work Plan and the a gency’s response to the public comment received during the 90 - day comment period on the RYH - 86 S ummary Document . No modifications were made to the Final Work Plan from the Preliminary Work Plan based on the one public comment received.  July 2 4, 2009 - EPA Published the July 13, 2009 Cancellation of Pesticides for Non Payment of Year 20 09 Registration Maintenance Fees in the Federal Register (7 4 FR 36699 ) (FRL - 8427 - 4 ) , which included among other products, the only two active U.S. registration for RYH - 86 , EPA Reg. No. 63898 - 1 , Ryh - 86NA, and EPA Reg. No. 74655 - 18, Spectrum RX7816 . A copy of the 20 09 cancel l ation order will be available in the docket at EPA - HQ - OPP - 200 8 - 0767 .Docket Number: EPA - HQ - OPP - 200 8 - 0767

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## 2 Background Information RYH - 86 is an antimicrobial pesticide which was previously registered for use as a n industrial slimicide for closed system injection into pulp and paper slurry in paper mills . A Reregistration Eligibility Decision (RED) was not completed for RYH - 86 because it was registered after November 1, 1984. The final two registration s have been cancel l ed as discussed below. The a gency had anticipated issuing the RYH - 86 Data C all - I n (DCI) in June of 201 0 , however due to the cancellation of the two remaining RYH - 86 registration s in the U.S. , the a gency did not issue the DCI. Existing stocks provisions included in the July 13, 20 09 cancellation order for non - payment of maintenance fees allow ed the registrant to sell and distribute Ryh - 86NA (EPA Reg. No. 63898 - 1 ) , and Spectrum RX7816 (EPA Reg. No. 74655 - 18) , the only two registered product s containing RYH - 86 until January 15, 20 10 , one year after the date on which the maintenance fee was due. Persons other than the registrant could continue to sell, distribute, and use RYH - 86 products until exhausted, provided that such sale, distribution, and use was consistent with the terms of the previously approved labeling on, or that accompanied, the c ance l l ed product . 

## 3 Registration Review Case Closure As stated in the RYH - 86 Preliminary Work Plan and Final Work Plan, the a gency had anticipated needing additional data to complete the risk assessment for RYH - 86 as part of registration review. However, due to the issuance of the July 13, 2009 cancellation order for the two remai ning RYH - 86 United States product registration s , the a gency has found that it is not necessary to complete new risk assessments for RYH - 86 and is, therefore, closing the registration revie w case for RYH - 86 pursuant to 40 CFR § 155.42(c), which provides that the a gency ''will close a registration review case if all products in the case are cancel l ed ." The existing stocks , sales and distribution deadlines included in the July 13 , 2009 cancellation order anticipate that RYH - 86 sale, distribution, and use will decline and eventually cease entirely in the U nited States. During the interim period, the a gency anticipates that existing stocks of RYH - 86 product s may be used until depleted without causing unreasonable risk to human hea lth and the environment. Pursuant to 40 CFR § 155.42(c), the a gency is closing the registration review case for RYH - 86 , thus concluding the RYH - 86 registration review, for the reasons discussed above.