6 July 2012

ONGOING HAZARD STUDIES FOR PMN SUBSTANCE [ TLF-11073, TLF-11191, TLF-11192 and TLF-11211 ]

Substance Study Type Study Location Expected

Date of In-life Completion Expected

Date of Final Report Verbal Results

if Available

[ TLF-11073 ] Local Lymph Node Assay [ Haskell ] 1 Complete Submitted with PMN Not a dermal

sensitizer

[ TLF-11073 ] Skin irritation [ IIVS ] 2 Complete Submitted with PMN Not a skin

irritant

[ TLF-11073 ] Eye Irritation [ IIVS ] 2 Complete Submitted with PMN Not an eye

irritant (GHS classification)

[ TLF-11073 ] Oral LD 50 (rat) [ Haskell ] 1 Complete Submitted with PMN LD 50 > 5000

mg/kg

[ TLF-11073 ] Bacterial Reverse Mutation [ Haskell ] 1 Complete Submitted with PMN Not mutagenic

[ TLF-11073 ] Chromosome Aberration

In Mammalian Cells [ Haskell ] 1 Complete July 2012 Negative for structural or numerical chromosome aberrations

[ TLF-11073 ] Acute inhalation [ Haskell ] 1 Complete Submitted with PMN ALC = 1200

mg/m 3 total atmospheric concentration; ALC = 700 mg/m 3 dry solids aerosol
[ TLF-11073 ] Inhalation NOEC [ Haskell ] 1 July 2012 TBD Not yet available

[ TLF-11073 ] 7-day Repeated Dose Oral

Gavage, Rat [ Haskell ] 1 TBD TBD Not yet available

[ TLF-11073 ] Daphnia Screen [ Haskell ] 1 Complete Submitted with PMN EC 50 > 120 mg

total solids/L

[ TLF-11073 ] 48-hr Daphnia EC 50 [ Haskell ] 1 Complete Submitted with PMN EC 50 > 526

mg/L (nominal); EC 50 > 102 mg total solids/L6 July 2012

[ TLF-11073 ] 21- Daphnia Chronic [ Haskell ] 1 July 2012 September 2012 Not yet

available

[ TLF-11073 ] 96-hr Trout LC 50 [ Haskell ] 1 Complete Submitted with PMN LC 50 > 526

mg/L (nominal); LC 50 > 110 mg total solids/L
[ TLF-11191 ] Algal Screen [ Haskell ] 1 Complete July 2012 Not yet available
[ TLF-11192 ] Algal Screen [ Haskell ] 1 Complete July 2012 Not yet available

[ TLF-11073 ] 96-hr Algae Growth Inhibition [ Haskell ] 1 Complete July 2012 The NOEC and LOEC values

were determined to be 175 and 526 mg/L (nominal), respectively; and 34.3 and 105 mg /L (total solids), respectively

[ TLF-11073 ] Ready Biodegradability [ Haskell ] 1 Complete Submitted with PMN Did not meet

criteria for “ready biodegradation”
[ TLF-11073 ] Hydrolysis waiver NA NA NA

[ TLF-11073 ] Activated Sludge

Respiration Inhibition [ Haskell ] 1 Complete Submitted with PMN Did not inhibit

microbial respiration at a nominal concentration of 1000 mg a.i./L

[ TLF-11073 ] Flash Point [ DuPont Explosions Hazards Laboratory ] 3 Complete Submitted with PMN No flash point

obtained

[ TLF-11073 ] Adsorption/Desorption [ IBACON ] 4 Complete July 2012 Not yet available
[ TLF-11073 ] Auto Ignition Temperature [ IBACON ] 4 Complete July 2012 Not yet available
[ TLF-11211 ] Melting Point [ Smithers Viscient ] 5 TBD TBD Not yet available6 July 2012

1 Studies conducted at [ DuPont Haskell Global Centers for Health and Enviro nment, 1090 Elkton Road, Newark, DE 19714 ]

2 Studies conducted at [ Institute for In Vitro Sciences, Inc., 30 W. Watkin s Mill Road, Suite 100, Gaithersburg, MD 20878 ]

3 Study conducted at [ DuPont Explosions Hazard Laboratory, Chambers Works Site, Deepwater, NJ 08023 ]

4 Studies conducted at [ IBACON, Institut für Biologische Analytik und Consulting IBACON GmbH, Arheilger Weg 17, 64380 Rossdorf, Germany ]

5 Studies to be conducted at [ Smithers Viscient (Covance Laboratories), Otley Roa d, Harrogate, HG3 1PY, United Kingdom ] [ TLF-11211 ] Flash Point [ Smithers Viscient ] 5 TBD TBD Not yet available
[ TLF-11211 ] Octanol/Water Partition

Coefficient [ Smithers

Viscient ] 5 TBD TBD Not yet available
[ TLF-11211 ] Relative Density [ Smithers Viscient ] 5 TBD TBD Not yet available
[ TLF-11211 ] Surface Tension [ Smithers Viscient ] 5 TBD TBD Not yet available
[ TLF-11211 ] Appearance of Substance [ Smithers Viscient ] 5 TBD TBD Not yet available

[ TLF-11211 ] Boiling Point

(Depends upon melting point results/possible waiver) [ Smithers

Viscient ] 5 TBD TBD Not yet available

[ TLF-11211 ] Vapor Pressure

(Depends upon melting point results/possible waiver) [ Smithers

Viscient ] 5 TBD TBD Not yet available

[ TLF-11211 ] Water Solubility waiver NA NA NA

[ TLF-11211 ] Explosive Properties waiver NA NA NA

[ TLF-11211 ] Oxidizing Properties waiver NA NA NA