6 July 2012 

 

ONGOING HAZARD STUDIES FOR PMN SUBSTANCE 

[TLF-11073, TLF-11191, TLF-11192 and TLF-11211]

Substance Study Type Study 

Location 

Expected 

Date of 

In-life 

Completion 

Expected 

Date of 

Final 

Report 

Verbal Results 

if Available 

[TLF-11073] Local Lymph Node Assay [Haskell]

1 Complete Submitted 

with PMN 

Not a dermal 

sensitizer 

[TLF-11073] Skin irritation [IIVS]

2 Complete Submitted 

with PMN 

Not a skin 

irritant 

[TLF-11073] Eye Irritation [IIVS]

2 Complete Submitted 

with PMN 

Not an eye 

irritant (GHS 

classification) 

[TLF-11073] Oral LD50 (rat) [Haskell]

1 Complete Submitted 

with PMN 

LD50 > 5000 

mg/kg 

[TLF-11073] Bacterial Reverse Mutation [Haskell]

1 Complete Submitted 

with PMN Not mutagenic 

[TLF-11073] Chromosome Aberration 

In Mammalian Cells [Haskell]

1 Complete July 2012 

Negative for 

structural or 

numerical 

chromosome 

aberrations 

[TLF-11073] Acute inhalation [Haskell]

1 Complete Submitted 

with PMN 

ALC = 1200 

mg/m3 total 

atmospheric 

concentration; 

ALC = 700 

mg/m3 dry 

solids aerosol 

[TLF-11073] Inhalation NOEC [Haskell]

1

July 2012 TBD Not yet 

available 

[TLF-11073] 7-day Repeated Dose Oral 

Gavage, Rat [Haskell]

1 TBD TBD Not yet 

available 

[TLF-11073] Daphnia Screen [Haskell]

1 Complete Submitted 

with PMN 

EC50 > 120 mg 

total solids/L 

[TLF-11073] 48-hr Daphnia EC50 [Haskell]

1 Complete Submitted 

with PMN 

EC50 > 526 

mg/L 

(nominal); 

EC50 > 102 mg 

total solids/L
6 July 2012 

 

[TLF-11073] 21- Daphnia Chronic [Haskell]

1

July 2012 September 

2012 

Not yet 

available 

[TLF-11073] 96-hr Trout LC50 [Haskell]

1 Complete Submitted 

with PMN 

LC50 > 526 

mg/L 

(nominal); LC50

> 110 mg total 

solids/L 

[TLF-11191] Algal Screen [Haskell]

1 Complete July 2012 Not yet 

available 

[TLF-11192] Algal Screen [Haskell]

1 Complete July 2012 Not yet 

available 

[TLF-11073] 96-hr Algae Growth 

Inhibition [Haskell]

1 Complete July 2012 

The NOEC and 

LOEC values 

were 

determined to 

be 175 and 526 

mg/L 

(nominal), 

respectively; 

and 34.3 and 

105 mg /L 

(total solids), 

respectively 

[TLF-11073] Ready Biodegradability [Haskell]

1 Complete Submitted 

with PMN 

Did not meet 

criteria for 

“ready 

biodegradation”

[TLF-11073] Hydrolysis waiver NA NA NA 

[TLF-11073]

Activated Sludge 

Respiration Inhibition [Haskell]

1 Complete Submitted 

with PMN 

Did not inhibit 

microbial 

respiration at a 

nominal 

concentration 

of 1000 mg 

a.i./L 

[TLF-11073] Flash Point 

[DuPont 

Explosions 

Hazards 

Laboratory]

3

Complete Submitted 

with PMN 

No flash point 

obtained 

[TLF-11073] Adsorption/Desorption [IBACON]

4 Complete July 2012 Not yet 

available 

[TLF-11073] Auto Ignition Temperature [IBACON]

4 Complete July 2012 Not yet 

available 

[TLF-11211] Melting Point [Smithers 

Viscient]

5 TBD TBD Not yet 

available 
6 July 2012 

 

1

Studies conducted at [DuPont Haskell Global Centers for Health and Environment, 1090 Elkton Road, Newark, DE 19714] 

2

Studies conducted at [Institute for In Vitro Sciences, Inc., 30 W. Watkins Mill Road, Suite 100, Gaithersburg, MD 20878]

3

Study conducted at [DuPont Explosions Hazard Laboratory, Chambers Works Site, Deepwater, NJ 08023] 

4

Studies conducted at [IBACON, Institut für Biologische Analytik 

und Consulting IBACON GmbH, Arheilger Weg 17, 64380 Rossdorf, Germany] 

5

Studies to be conducted at [Smithers Viscient (Covance Laboratories), Otley Road, Harrogate, HG3 1PY, United Kingdom]

[TLF-11211] Flash Point [Smithers 

Viscient]

5 TBD TBD Not yet 

available 

[TLF-11211] Octanol/Water Partition 

Coefficient 

[Smithers 

Viscient]

5 TBD TBD Not yet 

available 

[TLF-11211] Relative Density [Smithers 

Viscient]

5 TBD TBD Not yet 

available 

[TLF-11211] Surface Tension [Smithers 

Viscient]

5 TBD TBD Not yet 

available 

[TLF-11211] Appearance of Substance [Smithers 

Viscient]

5 TBD TBD Not yet 

available 

[TLF-11211] 

Boiling Point 

(Depends upon melting 

point results/possible 

waiver) 

[Smithers 

Viscient]

5 TBD TBD Not yet 

available 

[TLF-11211] 

Vapor Pressure 

(Depends upon melting 

point results/possible 

waiver) 

[Smithers 

Viscient]

5 TBD TBD Not yet 

available 

[TLF-11211] Water Solubility waiver NA NA NA 

[TLF-11211] Explosive Properties waiver NA NA NA 

[TLF-11211] Oxidizing Properties waiver NA NA NA