&\*W4'..c UNITED STATES ENVIRONMENTALPROTECTIONAGENCY 

# ,. fi "5 WASHINGTON, D.C. 20460

DP Barcode: D267178 PC Code: 101601
MEMORANDUM

Subject: Cyhexatin: Review of environmental fate and ecological effects data submitted insupport of registrationon hops.

From: Dana S. Spatz, RiskAssessment Proces

I Thomas Steeger, Ph.D., Fishery Biologis Environmental Risk Branch IV Environmental Fate and Effects Division Through: Mah Shamim, Ph.D., Chief Environmental Risk Branch IV Environmental Fate and Effects ~ivision
To: Akiva Abramovitch, PM Team Reviewer Tina Levine, Chief Insecticide/RodenticideBranch Registration Division

EFED has completed an initial screen of ElfAtochem's 3/27/2000 cyhexatin submission (MRID #s:45074701, 45126301, and 45110301 ) to determine if it adequately addressed any of the outstanding environmental fate or ecological effects data gaps. Unfortunately,we have concludedthat the data package does not provide the missing information needed to complete a risk assessment.
ECOLOGICAL 

### EFFECTS The report provides an overview of the ecotoxicology database for the organotin compound, and an assessment of the potential risksto nontarget organisms from cyhexatin use on hops. The report however does not address any of the outstanding data requirements, i.e., acute and chronic aquatic toxicity studies usingtechnical grade

### active ingredient, identified earlier by EFED. While the report cites acute and chronic aquatic toxicity data, it fails to notethat EFED classified many of the studies as invalid. Additionally, the data cited 

### in the report may significantly underestimate toxicity since many of the studies are based on nominal rather than mean measured concentrations. The following data requirements remain unfulfilled: 72-4(a) 72-4(a) 72-4(b) 72-1 72-1(a) 72-1(c) 72-3(a) 72-3(~) Freshwaterfish early life-stage (technical grade active ingredient [TGAI]) Estuarinelmarinefish early life-stage (TGAI) Freshwater invertebrate life cycle (TGAI) Freshwater invertebrate acute toxicity with Daphnia magna (TGAI) Freshwaterfish (warm water) acute toxicity with bluegill sunfish (TGAI) Freshwaterfish (coldwater) acute toxicity with rainbow trout (TGAI) Estuarinelmarine acute toxicity with sheepshead minnow (TGAI) Estuarinelmarine invertebrate with mysid shrimp (TGAI)

ENVIRONMENTAL FATE



### ElfAtochem submitted a four volume, I1 96 

### page compilation of mostly irrelevant information hopingto fulfill the environmental fate data gaps. Some of the impertinent information included inthe data packagewas, 1) previously submittedstudies, several of which were already determined to be invalid, 2) the entire TPTH RED, 3) 

### literature information onTributyltin, and 4) 

### data sheets in German. Several Europeanstudies on Azocyclotin, which hydrolyzesto cyhexatin, were included, howeverthese studies provided no information addressing the remainingdata requirements. Specifically, the photodegradation inwater (161 -2), photodegradationon soil (1 61-3), batch equilibrium (1

63-I), accumulation infish (1 65-4), andfield dissipation 

### (164-1) data requirements remain unfulfilled.CASE: 060207 SUBMISSION: S581867 DATA PACKAGE RECORD BEAN SHEET DATE: 07/05/00 Page 1 of 1

CASE TYPE: REGISTRATION ACTION: 010 NEW CHEMICAL SCREENING RANKING : 0 POINTS () CHEMICALS: 101601 Cyhexatin (ANSI) 96.0000%
ID#: 004581-GIE TECHNICAL CYHEXATIN COMPANY: 004581 ELF ATOCHEM NORTH AMERICA INC PRODUCT MANAGER: 04 TINA LEVINE 703-308-7055 ROOM: CM2 219 PM TEAM REVIEWER: AKIVA ABRAMOVITCH 703-308-8328 ROOM: CM2 207 RECEIVED DATE: 06/01/00 DUE OUT DATE: 07/31/00 

### * * 

## * DATA PACKAGE INFORMATION 

## * * 

## *

DP BARCODE: 267178 EXPEDITE: Y DATE SENT: 07/05/00 DATE RET.: 

### / / CHEMICAL : 101601 Cyhexatin (ANSI) DP TYPE: 001 CSF: N LABEL: N ASSIGNED TO DATE OUT ADMIN DUE DATE: 09/03/00

DIV : EFED 

## 7/ /f /60 NEGOT DATE: 

### / / BRAN: ERB4 

# 7 / c(/6~ PROJDATE: 

### / / SECT: 10 

## /rr /m REVR : CONTR : 

### / / 

## * * * DATA REVIEW INSTRUCTIONS 

### * 

## * *
review/screen MRID 45074701, 45126301 and 45110301 (already screened), any changes to data gaps? list data gaps 

## * * * DATA PACKAGE EVALUATION 

## * * *

No evaluation is written for this data package



## * * * ADDITIONAL DATA PACKAGES FOR THIS SUBMISSION 

### * 

## * *

DP BC BRANCH/SECTION DATE OUT DUE BACK INS CSF LABEL