### SAT Report PMN Number: P-12-0414 SAT Date: 6/29/2012 Print Date: 12/6/2012

Related cases : Health related cases:

Concern levels : Type of Concern: Health Eco Comments Level of Concern: 2 3

Persistence Bioaccum Toxicity Comments 1 12

Exposure Based Review : Health: Ecotox: N o
Routes of exposure : Health: Dermal Drinking Water Inhalation Ecotox: All releases to water Fate: ;

P 2 Rec Comments : Comment: P2REC: SAT: Do not forward: N o skin irritation study was submitted to support the claim that the PMN substance is less irritating than THFA.
Keywords : Keywords: MUTA; ONCO; DEVEL; IRR-S,E; LIVER; KIDNEY; SENS
Summary of Assessment :
Fate : Fate Summary: P-12-0414 FATE: Liquid with MP < 25 C (E) log Kow = 1.92 (M) S = 12.9 g/L at 25 C (M)VP = 4.7E-2 torr at 25 C ( N OMO5) BP = 236 C ( N OMO5) based on 100 C @ 5.3 mm Hg (M) H = 8.70E-8 (E) log Koc = 1.00 (E) log Fish BCF = 0.93 (E) log Fish BAF = 0.60 (E) POTW removal (%) = 90 via biodeg; OECD 301C(MITI): 28d: 29.7% (BOD), 33.1% (DOC), 100% (GC). Time for complete ultimate aerobic biodeg = wk-mo Sorption to soils/sediments = low PBT Potential: P1B1 *CEB FATE: Migration to ground water = rapid

Health : Health Summary: Moderate absorption from the skin and GI tract, good absorption from the lung (analog), expect Michael addition to the acrylate moieties. Concern for mutagenicity, oncogenicity, developmental, liver, and kidney toxicity, sensitization, and irritation from the acrylate.
Expect hydrolysis of the ketal in the stomach to yield methyl ethyl ketone. There is concern for developmental toxicity based on release of methyl ethyl ketone in the stomach. The oral RfD for methyl ethyl ketone is 0.6 mg/kg-day (IRIS) based on an oral (drinking water) multigeneration reproductive developmental study in rats for the analog 2-butanol which caused decreased pup weight at 594 mg/kg-day (LED05 = 639 mg/kg-day). Methyl ethyl ketone caused skeletal variations when tested in an inhalation developmental toxicity study in mice at 1764 p pm and the RfC for methyl ethyl ketone was set at 5 mg/m3 (IRIS). The inhalation study was not used to set the oral RfD because deficiencies in absorption data precluded using a route to route extrapolation to derive oral doses from existing inhalation data for methyl ethyl ketone. Test Data: (-) Salmonella with and without activation; (-) E. coli with and without activation; rat oral LD0 = 2000 mg/kg

Ecotox :
Test Organism Test Type Test End Point Predicted Measured Comments

fish 96-h LC50 2.8 daphnid 48-h LC50 7.0 green algal 96-h EC50 1.5 fish

_ chronic value 0.020 daphnid

_ chronic value 0.31
algal

_ chronic value 0.40
Sewage Sludge 3-h EC50

_Sewage Sludge

_ Chronic Value _

Ecotox Values Comments: Predictions are based on SARs for acrylates; SAR chemical class = acrylate; liquid (P) with mp unk; MW 200; S = 2.38 g/L at 25 C, p H 7 (P); log Kow = 2.07 (EPI); effective concentrations based on 100% active ingredients and nominal concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments Assessment Factor 10 Concentration of Concern ( p pb) 2

SARs acrylates SAR Class acrylate Ecotox Category Acrylates/Methacrylates

Ecotox Factors Comments:

SAT Chair: L Keifer 564-8916