<PAGE>
 
 
                                   FORM 10-Q/A

                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                              AMENDMENT NO. 1 TO

(Mark One)

[X]             QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d)
                    OF THE SECURITIES EXCHANGE ACT OF 1934
               For the quarterly period ended September 30, 1997

                                      OR

[_]                TRANSITION REPORT UNDER SECTION 13 OR 15(d)
                    OF THE SECURITIES EXCHANGE ACT OF 1934
           For the transition period from ___________ to ___________

                        Commission file number  0-13966
                                               ---------

                          Premier Laser Systems, Inc.
                          ---------------------------
            (Exact name of registrant as specified in its charter)

            California                              33-0476284
            ----------                              ----------  
(State or other jurisdiction of         (I.R.S. Employer Identification No.)
incorporation or organization)  

                      3 Morgan, Irvine, California, 92618
                      -----------------------------------
                   (Address of principal executive offices)

                                 (714) 859-0656
                                 --------------
              (Registrant's telephone number, including area code)

                       ---------------------------------
   (Former name, former address and former fiscal year, if changed since last
                                    report)

     Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days.
Yes  X    No 
    ---      ---    

               APPLICABLE ONLY TO ISSUERS INVOLVED IN BANKRUPTCY
                 PROCEEDINGS DURING THE PRECEDING FIVE YEARS:

     Indicate by check mark whether the registrant has filed all documents and
reports required to be filed by Sections 12, 13 or 15(d) of the Securities
Exchange Act of 1934 subsequent to the distribution of securities under a plan
confirmed by a court.
Yes       No 
    ---      ---
                     APPLICABLE ONLY TO CORPORATE ISSUERS:
     Indicate the number of shares outstanding of each of the issuer's classes
of common stock, as of the latest practicable date (November 12, 1997):
<TABLE>
<CAPTION>
 
<S>                                           <C>          <C>
                 Class A Common Stock:        12,332,931   Shares
                                              ----------
                 Class E-1 Common Stock:       1,257,499   Shares
                                              ----------
                 Class E-2 Common Stock:       1,257,499   Shares
                                              ----------
</TABLE>

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          The sole purpose of this Amendment is to file Exhibits 10.1 and 10.2 
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          hereto.
          ------


Item 6.   Exhibits and Reports on Form 8-K.
          -------------------------------- 

     (a)  Exhibits.

<TABLE> 
<CAPTION> 

Exhibit
Number                        Description
-------                       -----------
<C>      <S> 
2.1      Agreement and Plan of Merger dated as of April 24, 1997 among Premier
         Laser Systems, Inc., EyeSys Technologies, Inc. and Premier Acquisition
         of Delaware, Inc. (incorporated herein by this reference to Exhibit 2.1
         to the Registrant's Registration Statement on Form 4, Registration No.
         333-29573).

2.2      First Amendment to Agreement and Plan of Merger dated as of August 6,
         1997 among Premier Laser Systems, Inc., EyeSys Technologies, Inc. and
         Premier Acquisition of Delaware, Inc. (incorporated herein by this
         reference to Exhibit 2.2 to the Registrant's Current Report on Form 8-K
         filed October 14, 1997).

2.3      Second Amendment to Agreement and Plan of Merger dated as of September
         16, 1997 among Premier Laser Systems, Inc., EyeSys Technologies, Inc.
         and Premier Acquisition of Delaware, Inc. (incorporated herein by this
         reference to Exhibit 2.3 to the Registrant's Current Report on Form 8-K
         filed October 14, 1997).

10.1     Loan Agreement dated September 24, 1997 between Silicon Valley Bank 
         and EyeSys Technologies, Inc. (filed herewith)

10.2     Third Party Security Agreement dated September 24, 1997 between  
         Silicon Valley Bank and Premier Laser Systems, Inc. (filed herewith)

27       Financial Data Schedule (previously filed)

         (b) Reports on Form 8-K:  No Reports on Form 8-K were filed during the
quarter ended September 30, 1997.
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     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this Amendment to be signed on its behalf by the
undersigned, thereunto duly authorized.

                             PREMIER LASER SYSTEMS, INC.

                                
Dated:  November 26, 1997    By:    /s/ MICHAEL HIEBERT
                                ----------------------------------------------
                                    Michael Hiebert, Chief Financial Officer
                                    (duly authorized officer)

                                
Dated:  November 26, 1997    By:    /s/ MICHAEL HIEBERT
                                ----------------------------------------------
                                    Michael Hiebert, Chief Financial Officer
                                    (Principal Financial Officer and Principal
                                    Accounting Officer)

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