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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549





FORM 10-K







|x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ------------------------------------------------------------------------------------

FOR THE FISCAL YEAR ENDED DECEMBER 31, 2008, OR



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

FOR THE TRANSITION PERIOD FROM                     
TO

Commission file number 000-51462





CHELSEA THERAPEUTICS
INTERNATIONAL, LTD.

(Exact name of Registrant as specified in its charter)







|                                                               |  |                                     
|-------------------------------------------------------------- |  | ------------------------------------
|Delaware                                                       |  | 20-3174202                          
|(State or other jurisdiction of incorporation or organization) |  | (I.R.S. Employer Identification No.)

3530 Toringdon Way, Suite 200, Charlotte, North Carolina 28277

(Address of principal executive offices, including zip code)

(704) 341-1516

(Registrants telephone number, including area code)







|                                |  |                                          
|------------------------------- |  | -----------------------------------------
|Title of each class             |  | Name of each exchange on which registered
|Common Stock, $0.0001 Par Value |  | Nasdaq Capital Market                    

Securities registered pursuant to Section 12(g) of the Act:

Common Stock, $0.0001 Par Value





Indicate by check mark if the
Registrant is a well-known seasoned issuer (as defined in Rule 405 of the Securities Act). Yes   ̈    No  x

Indicate by check mark if the Registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act.
Yes   ̈    No  x

Indicate by
check mark whether the Registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934, as amended, during the preceding 12 months (or for such shorter period that the Registrant was
required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes  x    No   ̈

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not
contained herein, and will not be contained, to the best of Registrants knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form
10-K.    x

Indicate by check mark whether the Registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of large accelerated filer, accelerated filer and smaller reporting company in Rule 12b-2 of the Exchange
Act (Check one):



|                              |  |                              
|----------------------------- |  | -----------------------------
|Large accelerated filer      ̈ |  | Accelerated filer     x      
|Non-accelerated filer      ̈   |  | Smaller reporting company    ̈

Indicate by check mark whether the Registrant is a shell company (as defined in Rule 12b-2 of the
Act).    Yes   ̈    No  x

The aggregate market value of the registrants common stock held by non-affiliates of the Registrant, based on the closing price of the Registrants common stock on June 30, 2008 ($4.88 per share) was
$116,465,827. This determination of affiliate status is not necessarily a conclusive determination for other purposes.

At March 3, 2009,
30,111,479 shares of the Registrants common stock, $.0001 par value per share, were outstanding.

Documents Incorporated By
Reference

Portions of the Registrants definitive Proxy Statement to be filed for its 2009 Annual Meeting of Stockholders
currently scheduled to be held May 27, 2009 are incorporated by reference into Part III of this report.









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ANNUAL REPORT ON FORM 10-K

Table of Contents



|           |  |                                                                                                                |  |     
|---------- |  | -------------------------------------------------------------------------------------------------------------- |  | ----
|           |  |                                                                                                                |  | Page
|           |  |                                                                                                               
|           |  | PART I                                                                                                         |  |     
|           |  |                                                                                                               
|Item 1.    |  | Business                                                                                                       |  | 1   
|           |  |                                                                                                               
|Item 1A.   |  | Risk Factors                                                                                                   |  | 20  
|           |  |                                                                                                               
|Item 1B.   |  | Unresolved Staff Comments                                                                                      |  | 32  
|           |  |                                                                                                               
|Item 2.    |  | Properties                                                                                                     |  | 32  
|           |  |                                                                                                               
|Item 3.    |  | Legal Proceedings                                                                                              |  | 32  
|           |  |                                                                                                               
|Item 4.    |  | Submission of Matters to a Vote of Security Holders                                                            |  | 32  
|           |  |                                                                                                               
|           |  | PART II                                                                                                        |  |     
|           |  |                                                                                                               
|Item 5.    |  | Market for Registrants Common Equity, Related Stockholder Matters and Issuer Repurchases of Equity Securities |  | 33  
|           |  |                                                                                                               
|Item 6.    |  | Selected Consolidated Financial Data                                                                           |  | 34  
|           |  |                                                                                                               
|Item 7.    |  | Managements Discussion and Analysis of Financial Condition and Results of Operations                          |  | 35  
|           |  |                                                                                                               
|Item 7A.   |  | Quantitative and Qualitative Disclosures about Market Risk                                                     |  | 48  
|           |  |                                                                                                               
|Item 8.    |  | Financial Statements and Supplementary Data                                                                    |  | 49  
|           |  |                                                                                                               
|Item 9.    |  | Changes in and Disagreements with Accountants on Accounting and Financial Disclosure                           |  | 49  
|           |  |                                                                                                               
|Item 9A.   |  | Controls and Procedures                                                                                        |  | 49  
|           |  |                                                                                                               
|Item 9B.   |  | Other Information                                                                                              |  | 51  
|           |  |                                                                                                               
|           |  | PART III                                                                                                       |  |     
|           |  |                                                                                                               
|Item 10.   |  | Directors, Executive Officers and Corporate Governance                                                         |  | 52  
|           |  |                                                                                                               
|Item 11.   |  | Executive Compensation                                                                                         |  | 52  
|           |  |                                                                                                               
|Item 12.   |  | Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters                 |  | 52  
|           |  |                                                                                                               
|Item 13.   |  | Certain Relationships and Related Transactions, and Director Independence                                      |  | 52  
|           |  |                                                                                                               
|Item 14.   |  | Principal Accounting Fees and Services                                                                         |  | 52  
|           |  |                                                                                                               
|           |  | PART IV                                                                                                        |  |     
|           |  |                                                                                                               
|Item 15.   |  | Exhibits, Financial Statement Schedules                                                                        |  | 53  
|           | 
|SIGNATURES |  | 56                                                                                                            



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PART I

Except for the historical information contained herein, the matters set forth in this Report include forward-looking statements within the meaning of the safe harbor provisions of the Private Securities
Litigation Reform Act of 1995. These forward-looking statements are subject to risks and uncertainties that may cause actual results to differ materially. These risks and uncertainties are detailed throughout the report and will be further discussed
from time to time in our periodic reports filed with the Securities and Exchange Commission. The forward-looking statements included in this Report speak only as of the date hereof.

ITEM 1. DESCRIPTION OF BUSINESS.

Overview

We are a development stage pharmaceutical company that seeks to acquire, develop and commercialize innovative products for the treatment of a variety of
human diseases. Our strategy is to develop technologies that address important unmet medical needs or offer improved, cost-effective alternatives to current methods of treatment. We are currently focusing the majority of our drug development
resources on two clinical stage development projects: droxidopa for symptomatic neurogenic orthostatic hypotension and other potential indications; and our portfolio of non-metabolized antifolate compounds for the treatment of rheumatoid arthritis.

Product Pipeline Summary

We are
developing droxidopa, an orally active synthetic precursor of norepinephrine and our most advanced investigational product candidate, for the treatment of neurogenic orthostatic hypotension (NOH). Currently approved and marketed in Japan for the
treatment of symptomatic orthostatic hypotension, freezing gait in Parkinsons disease and intradialytic hypotension, droxidopa has accumulated over 20 years of proven safety and efficacy, historically generating annual revenues of
approximately $50 million in Japan. Droxidopa is currently being studied in two double-blind pivotal Phase III trials designed to compare droxidopa to placebo at multiple sites in North America, Europe and Australia. Droxidopa is also being
developed for the treatment of intradialytic hypotension for which we have just completed a double-blind, placebo controlled Phase II study in the United States. In addition, a Phase II trial of droxidopa, alone and in combination with carbidopa,
for the treatment of fibromyalgia began in early 2009, under approval from the United Kingdoms Medicines and Healthcare Products Regulatory Agency.

In addition to droxidopa, we are currently developing a portfolio of molecules for the treatment of various autoimmune/inflammatory diseases. The most advanced platform is a portfolio of metabolically inert antifolate
molecules engineered to have potent anti-inflammatory and anti-tumor activity to treat a range of immunological disorders, including two clinical stage product candidates; CH-1504 and CH-4051. Both are orally available molecules with
anti-inflammatory, autoimmune and anti-tumor properties that potently inhibit several key enzymes that are required for cell proliferation. Preclinical and clinical data to date suggests superior safety and tolerability, as well as increased potency
versus methotrexate (MTX), currently the leading antifolate treatment and standard of care for a broad range of abnormal cell proliferation diseases. Diseases that may potentially be treated with these compounds include rheumatoid arthritis,
psoriasis, inflammatory bowel disease, psoriatic arthritis and several different kinds of cancer. CH-1504 is currently being investigated for the treatment of rheumatoid arthritis in a Phase II head-to-head clinical trial to compare its efficacy and
tolerability against MTX. CH-4051 is currently being investigated in a Phase I study designed to determine the maximum tolerated dose based on results of single-ascending and multiple-ascending dose evaluations. Complementing our antifolate program
is a second platform consisting of a portfolio of dihydroorotate dehydrogenase, or DHODH, inhibiting compounds known as the I-3D portfolio. Current preclinical animal data for this portfolio of compounds have shown potential applications in
autoimmune diseases and transplantation.



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We also remain active in evaluating potential in-licensing and acquisition candidates to identify and
acquire additional drug candidates as available funding might allow.

To date, we have not received approval for the sale of any of our
drug candidates in any market and, therefore, have not generated any revenues from our drug candidates.

Our Strategy

Our mission is to create long-term stockholder value by acquiring, developing and commercializing innovative products for the treatment of a variety of
human diseases that address important unmet medical needs or offer improved, cost-effective alternatives to current methods of treatment. Since inception in 2002, we have focused primarily on organizing and staffing our company, negotiating
in-licensing agreements with our partners, acquiring, developing and securing our proprietary technology, participating in regulatory discussions with the United States Food and Drug Administration, or the FDA, the European Medicines Agency, or the
EMEA, and other regulatory agencies, undertaking preclinical and clinical trials of our product candidates and raising capital. We are a development stage company and have generated no revenues since inception. We do not anticipate generating any
product revenue until approvals are successfully obtained from the FDA or equivalent foreign regulatory bodies to begin selling pharmaceutical/biotech candidates.

We expect the progress of our development programs to be a primary factor affecting our expenses, losses and cash position in the future. During 2008 and in early 2009, we initiated, plan to initiate or completed
clinical trials as follows:



| |  |  | Phase III pivotal clinical programs for droxidopa in neurogenic orthostatic hypotension, requiring up to approximately 200 patients;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Phase II program for CH-1504 in rheumatoid arthritis, requiring approximately 200 patients;
| | - |  | -------------------------------------------------------------------------------------------



| |  |  | Phase II program for droxidopa in hypotension associated with dialysis, requiring approximately 75 patients;
| | - |  | ------------------------------------------------------------------------------------------------------------



| |  |  | Phase II program for droxidopa in fibromyalgia, requiring approximately 120 patients; and
| | - |  | -----------------------------------------------------------------------------------------



| |  |  | Phase I single and maximum tolerated dose (MTD) studies for CH-4051 requiring approximately 80 patients.
| | - |  | --------------------------------------------------------------------------------------------------------

We also continue to discuss our antifolate program with large pharmaceutical companies to gauge their interest in licensing this library of compounds. We
believe a partner may be able to manage Phase III trials and global commercialization more effectively and with less risk than we could and, accordingly, our current strategy is to pursue such a partnership. Similarly, as we are currently not
planning to establish commercial operations outside of the United States, we continue to discuss potential licensing arrangements for droxidopa in Europe and other markets outside the United States. In the course of these discussions, the program
has generated interest among potential partners and we continue to evaluate the licensing potential for droxidopa in North America. Any such partnership would aim to provide significant value to us and our stockholders, while maximizing the
opportunities for droxidopa in global markets. We also continue to pursue and evaluate potential out-licensing arrangements for our I-3D portfolio of DHODH inhibiting compounds.

We have retained a management team with leading core competencies and expertise in numerous fields, including manufacturing, research, clinical,
regulatory and business development. Our management and advisors are comprised of experienced pharmaceutical and biotechnology industry veterans and respected experts. We are led by our Chief Executive Officer, Dr. Simon Pedder, formerly Vice
President, Pharmaceutical Business, Oncology at Hoffmann-La Roche Inc., who has over 20 years of senior pharmaceutical management experience, including drug development and business experience. During his time at Roche, Dr. Pedder was
responsible for a number of global development programs, successful registrations and product launches.



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Plan of Operation

Our plan of operation is to continue implementing our business strategy, especially the clinical development of our current drug candidates including droxidopa and our portfolio of antifolates. As we have in the past,
we plan to continue exploring the feasibility of other licensed or newly developed compounds and to expand our drug candidate portfolio by acquiring additional drug technologies for development as our resources permit. We expect our principal
expenditures during the next 18 months to include:



| |  |  | operating expenses, including marketing, general and administrative and business development expenses; and
| | - |  | ----------------------------------------------------------------------------------------------------------



| |  |  | product development expenses, including the costs incurred with respect to our clinical trials for droxidopa and our antifolates.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------

As part of meeting our operating needs and as resources permit, we may hire additional scientific, marketing, and administrative staff. In addition, we
intend to continue using clinical research organizations and third parties to perform our clinical studies and manufacturing.

Corporate History

Our operating company was incorporated in Delaware in April 2002 under the name Aspen Therapeutics, Inc., and changed its name to Chelsea
Therapeutics, Inc. in July 2004. On February 11, 2005, Chelsea Therapeutics, Inc. completed a merger with Ivory Capital Corporation, a publicly traded Colorado corporation formed in May 1988. At the time of the transaction, Ivory Capital had
only nominal assets and no operating activities. In connection with this merger transaction, a wholly owned subsidiary of Ivory Capital Corporation merged with and into Chelsea Therapeutics, Inc., with Chelsea Therapeutics, Inc. remaining as the
surviving corporation and a wholly owned subsidiary of Ivory Capital Corporation. In connection with the merger, the former stockholders of Chelsea Therapeutics, Inc. received 96.75% percent of our outstanding equity on a fully diluted basis.
Pursuant to the terms of the merger, the sole officer and director of Ivory Capital Corporation prior to the merger was replaced with the officers and directors of Chelsea Therapeutics, Inc.

On June 17, 2005, Ivory Capital Corporation formed a wholly owned subsidiary in Delaware named Chelsea Therapeutics International, Ltd. for the
purposes of reincorporating in Delaware. On July 28, 2005, Ivory Capital Corporation merged with Chelsea Therapeutics International, Ltd., with Chelsea Therapeutics International, Ltd. as the surviving corporation. As a result, Chelsea
Therapeutics International, Ltd. is the public reporting company and is the 100% owner of Chelsea Therapeutics, Inc., its operating subsidiary.

Except where the context provides otherwise, references to we, us, our and similar terms mean Chelsea Therapeutics International, Ltd., Ivory Capital Corporation and Chelsea Therapeutics, Inc. When we
refer to business and financial information relating to periods prior to December 31, 2004, we are referring to the business and financial information of Chelsea Therapeutics, Inc. unless the context requires otherwise. When we refer to
business and financial information for periods between January 1, 2005 and July 28, 2005, we are referring to the business and financial information of Ivory Capital Corporation.

Products Under Development

DROXIDOPA

Product Overview

Droxidopa, a synthetic amino acid,
is converted by the body into norepinephrine and, as a prodrug of norepinephrine, provides replacement therapy for norepinephrine deficiency. Norepinephrine is both a hormone and a neurotransmitter. As a hormone, secreted by the adrenal gland, it
works alongside epinephrine/adrenaline to give the body sudden energy in times of stress, known as the fight or flight response. As a neurotransmitter, it passes nerve impulses from one neuron to the next. While norepinephrine, as a
catecholamine does not



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penetrate the blood-brain barrier, droxidopa, as a neutral amino acid, is able to do so thus providing both a peripheral and central effect on circulating
norepinephrine levels. By producing and replenishing depleted norepinephrine via endogenous enzymatic pathway, droxidopa is believed to allow for the re-uptake of norepinephrine into peripheral and central nervous system neurons.

Droxidopa is currently approved and marketed by Dainippon Sumitomo Pharma Co., Ltd., or DSP, in Japan for the treatment of symptomatic orthostatic
hypotension, freezing gait in Parkinsons disease and hypotension associated with dialysis. Droxidopa received initial Japanese marketing approval in 1989 and has historically generated annual revenues of approximately $50 million in Japan. In
addition to the indications studied by DSP and subsequently approved in Japan, diseases that may potentially be treated with droxidopa include fibromyalgia, chronic fatigue syndrome, attention deficit hyperactivity disorder (ADHD), and other
indications in which norepinephrine deficiencies are believed to play a role.

Clinical Development

We are currently focusing our internal resources on the clinical development of droxidopa in three indications: symptomatic neurogenic orthostatic
hypotension; intradialytic hypotension; and fibromyalgia. In order to maximize the potential therapeutic applications of droxidopa while conserving capital, we have also been exploring opportunities to support, through the provision of drug
substance, additional, investigator-sponsored studies of droxidopa in indications for which we believe a strong clinical rationale exists.

Neurogenic
Orthostatic Hypotension

Given the extensive body of clinical data generated by DSP and exclusively available to us under terms of our
licensing agreement, we are currently seeking initial marketing approval of droxidopa in the United States and European Union for the treatment of symptomatic neurogenic orthostatic hypotension (NOH), an indication for which the drug has been
approved in Japan since 1989.

Orthostatic hypotension is a sudden decrease in blood pressure when a person assumes a standing position and
is characterized by lightheadedness, dizziness, blurred vision and syncope. There are multiple known causes for orthostatic hypotension including those that are considered cardiovascular, endocrine and neurological (or neurogenic) in nature.
Neurogenic orthostatic hypotension results from a deficient release and/or activity of norepinephrine, a neurotransmitter used by autonomic nerves to send signals to the blood vessels and the heart.

We estimate that nearly 300,000 patients suffer from chronic, symptomatic NOH in the United States and the European Union combined. This condition is
commonly associated with Parkinsons disease, pure autonomic failure and multiple system atrophy, the latter encompassing disorders previously known as striatonigral degeneration, olivoponto-cerebellar atrophy and the Shy-Drager syndrome.

In January 2007, the FDA granted orphan drug status for droxidopa for the treatment of symptomatic NOH in patients with primary autonomic
failure (Parkinsons disease, multiple system atrophy (MSA), and pure autonomic failure (PAF)), dopamine-ß-hydroxylase deficiency, or nondiabetic autonomic neuropathy. In the United States, orphan drug status provides seven years of
marketing exclusivity and may impact FDA requirements for clinical trials, potentially reducing the time and expense required for such trials. In August 2007, the European Commission granted two orphan medicinal product designations for droxidopa
for the treatment of orthostatic hypotension in patients with PAF and MSA. Although we can expect 10 years of data exclusivity for droxidopa upon approval in Europe as a new chemical entity, orphan drug status could impact requirements for clinical
trials in Europe, thereby reducing the time and costs associated with our development of droxidopa for this market.

The FDA has also
granted Fast Track designation to droxidopa for symptomatic NOH. Fast Track designation is designed to facilitate the review of products that address serious or potentially life-threatening



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conditions for which there is an unmet medical need. Fast Track designation allows a company to file a New Drug Application (NDA) on a rolling basis as data
becomes available. This permits the FDA to review the filing as it is received, rather than waiting for the entire document prior to commencing the review process. In addition, drugs that have Fast Track designation are more likely to be considered
appropriate for Priority Review. A Priority Review generally reduces the time it takes the FDA to review a new drug application.

In
February 2008, we initiated a Phase III clinical program in symptomatic NOH. Our phase III program for droxidopa consists of two similar double-blind pivotal trials (Study 301 and Study 302) designed to compare droxidopa to placebo at multiple sites
in North America, Europe and Australia. Both Phase III trials are intended to assess the safety and efficacy of droxidopa in patients suffering from symptomatic NOH associated with Parkinsons disease, PAF and MSA with the primary efficacy
endpoint being defined as the relative symptomatic change, as measured by the mean score of Item 1 (dizziness or lightheadedness) of the Orthostatic Hypotension Symptom Assessment, 14 days following randomization either to continued therapy
with droxidopa or to placebo in Study 302 and seven days in Study 301.

In February 2008, we reached an agreement with the FDA on a Special
Protocol Assessment (SPA) for the design of Study 301. The SPA process allows for FDA evaluation of a clinical trial protocol intended to form the primary basis of an efficacy claim in support of a new drug application, and provides a binding
agreement that the study design, including trial size, clinical endpoints and/or data analyses are acceptable to support regulatory approval.

Results from our two ongoing global Phase III trials, in combination with data secured from DSP, are expected to support applications for marketing approval in both the United States and the European Union, although we believe at least one
additional trial may be required for approval in the European Union. We cannot predict with certainty the timing of our clinical trials. However, we currently estimate market launch no sooner than the second half of 2010.

Intradialytic Hypotension

Intradialytic hypotension,
or IDH, is another indication for which DSP conducted extensive clinical evaluation. Pivotal clinical studies conducted by DSP have demonstrated the efficacy of droxidopa in the prevention of vertigo, dizziness and weakness associated with
hypotension in hemodialysis patients. Subsequently, in 2000, after showing benefit in clinical trials, DSP received expanded marketing approval in Japan for this indication.

Intradialytic hypotension is the most common adverse event during routine hemodialysis. IDH is often defined as a decrease in systolic blood pressure by
3 20 mm Hg or a decrease in mean arterial pressure by 10 mm Hg. IDH has been reported in 15-25% of all hemodialysis patients, with elderly patients reporting an even higher incidence. Many adverse hemodialysis events,
including headaches, lightheadedness, nausea, cramps, and seizures, are associated with IDH. These complications can routinely interrupt dialysis sessions, resulting in insufficient uremia toxin removal and necessitating repetition of the procedure.
Interruptions due to IDH increase the costs of both the dialysis treatment sessions and the long-term care of less healthy hemodialysis patients.

In March of 2009, we reported results from a double-blind, placebo controlled trial comparing 400mg and 600mg of droxidopa to placebo. Following a two-week run-in period to establish a baseline for all measurements, patients in this
three-arm study received a single oral dose of droxidopa or placebo one hour prior to each dialysis treatment over a four-week period. The study recruited 85 patients at 15 sites in the United States. Droxidopa demonstrated a dose dependent,
statistically significant benefit across multiple, clinically relevant assessment criteria for IDH. The data also showed that droxidopa was well tolerated by patients with the most common treatment related side



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effect reported being headache (3%). Results from this study might be used to determine clinical endpoints for a potential future Phase III program that
might allow us to file for the first marketing approval of a therapeutic agent for IDH in the United States.

Fibromyalgia

Fibromyalgia is a polysymptomatic syndrome characterized by chronic, widespread musculoskeletal pain, multiple tender points, abnormal pain sensitivity,
and is often accompanied by severe fatigue, insomnia and mood symptoms. According to the American College of Rheumatology, fibromyalgia is the second most commonly diagnosed condition in rheumatology clinics in the United States after osteoarthritis
and is estimated to affect over six million Americans. While the precise etiology of fibromyalgia remains unknown, current research includes the role of norepinephrine reuptake and availability in the central nervous system. Norepinephrine, a widely
used neurotransmitter in the central and peripheral nervous systems, has long been linked to both chronic pain and depression. While norepinephrine, as a catecholamine, does not penetrate the blood-brain barrier, droxidopa, as a neutral amino acid,
is able to do so thus providing both a peripheral and central affect on circulating norepinephrine levels. In prior studies conducted by DSP, droxidopa has shown statistically significant dose-dependent analgesia in chronic pain.

We initiated a Phase II trial of droxidopa, both alone and in combination with carbidopa for the treatment of Fibromyalgia in January 2009. The Phase II
trial, being conducted in the U.K., is a multi-centre, randomized, double-blind, placebo-controlled, dose response, factorial 12-arm parallel group study evaluating 120 patients equally randomized to receive droxidopa monotherapy, carbidopa
monotherapy, droxidopa/carbidopa combination therapy or placebo. Accordingly, 10 patients will be randomized into each of 12 groups to receive: 200mg, 400mg or 600 mg of droxidopa TID; 25mg or 50mg carbidopa TID; 200/25mg, 400/25mg or 600/25mg
droxidopa/carbidopa TID; 200/50mg, 400/50mg or 600/50mg droxidopa/carbidopa TID; or placebo over a 9-week treatment period. The primary endpoint will be the average reduction in pain as measured by the Short Form McGill Pain Questionnaire. Secondary
outcomes of the study include Fibromyalgia Index Questionnaire (FIQ), Patient Global Impression of Change (PGI-C), Multidimensional Fatigue Inventory (MFI), and Hamilton Anxiety Depression survey (HAMA).

Given significant market opportunity associated with fibromyalgia, the number of on-going and anticipated clinical trials related to this indication, and
the competition for both physicians and patients, we currently do not anticipate completing this trial or reporting clinical results in this indication until late 2010 at the earliest.

Additional Potential Indications for Droxidopa

In addition to the indications for which we have
established active clinical programs, we believe there are a significant number of other therapeutic indications in which norepinephrine function plays a key role and for which droxidopa may provide clinical benefit. To facilitate research in
additional indications and maximize the long-term development potential, we have initiated an extra-mural development program that enables independent investigators to conduct clinical trials in their respective fields of expertise. There are
currently three pilot clinical studies, under investigator-sponsored investigational new drug applications (IND), expected to begin in 2009. These planned Phase II studies are intended to evaluate the safety and efficacy of droxidopa in adult
attention deficit and hyperactivity disorder (ADHD), chronic fatigue syndrome and freezing of gait in Parkinsons disease respectively. As these studies will be conducted under investigator-sponsored INDs, we will have limited control over the
timing for initiating or completing these studies and, therefore, cannot predict with any certainty when data from these programs will be available.

We plan to continue working with key opinion leaders to identify and evaluate additional potential indications for droxidopa and may provide droxidopa for future studies when deemed appropriate and as funding and
availability of drug substance permits.



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Droxidopa Competition

Neurogenic Orthostatic Hypotension

Midodrine(ProAmatine®)

Midodrine is
currently the only FDA approved therapeutic for the treatment of orthostatic hypotension. Midodrine, originally developed by Roberts Pharmaceuticals (later acquired by Shire) under the brand name ProAmatine®, is an alpha-agonist that works by stimulating alpha receptors, consequently increasing vasculature tone and thereby producing an elevation in blood pressure. Given this direct mechanism of action, it is not
surprising that supine hypertension is the most frequently occurring adverse event associated with its use. Midodrines product label contains a black box warning for this side effect.

Other than the increase in blood pressure caused by vasoconstriction, additional midodrine side effects include paresthesia, piloerection, dysuria, and
pruritis. Annual sales (branded and generic) in the United States total approximately $60 million, based on 2005 data. In addition to Shires manufacturing of the ProAmatine brand, Mylan Pharmaceuticals, Eon Labs and Impax Laboratories are
generic manufacturers of the compound.

Fludrocortisone(Florinef®)

Fludrocortisone is also widely used in the treatment of orthostatic hypotension although this specific
indication has not been approved by the FDA. Fludrocortisone is a synthetic adrenocortical steroid possessing very potent mineralocorticoid properties and high glucocorticoid activity. Fludrocortisone, in small oral doses (0.1 mg.) produces marked
sodium retention and increased urinary potassium excretion leading to enhanced plasma volume and a rise in blood pressure. Side effects include hypertension, water and sodium retention and K+ loss. Fludrocortisone is not FDA approved for NOH and the
mechanism of action for fludrocortisone does not specifically address this indication.

Intradialytic Hypotension

There is currently no FDA approved drug for treatment or prevention of intradialytic hypotension. Common methods for treating IDH include the manual
adjustment of ultrafiltration rate, a cumbersome procedure in daily practice. Some dialysis patients are known to take Midodrine prophylactically, either before or during dialysis, to prevent intradialytic hypotension. However, Midodrine is known to
be eliminated through the kidneys and is removed by dialysis, thereby limiting its widespread use in this indication.

Fibromyalgia

While doctors have used antidepressants and pain drugs for years, in June 2007, the FDA granted its
first approval for the treatment of fibromyalgia to Phizers Lyrica®, which was already used to treat epilepsy and neuropathic pain. Eli Lilly received approval in 2008 to market
Cymbalta®, a selective serotonin and norepinephrine reuptake inhibitor, to treat fibromyalgia and Cypress Biosciences, with their partner Forest Laboratories, received FDA approval in early
2009 for Savella® for the treatment of fibromyalgia. Savella® is a norepinephrine serotonin reuptake inhibitor that increases the
level of norepinephrine more than it does serotonin.

Droxidopa Marketing

We do not currently have a commercial sales and marketing organization in any territory and do not plan to establish the necessary infrastructure to
support future sales outside of the United States. As a result, we would expect to partner with or license droxidopa to companies with established infrastructure in the European Union and other markets. With regard to the United States, we believe
that the market for droxidopa in NOH, our most immediate commercial opportunity, could be addressed through the establishment of a marketing and sales organization on a stand-alone basis. During 2008, we conducted studies to further evaluate the
marketing potential and pricing opportunities for droxidopa in the United States. The favorable results of these studies were



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suggestive of a significant market opportunity. Given the attractive commercial opportunity and the nature of marketing a drug under orphan drug protection,
there may exist an opportunity for us to more effectively pursue co-marketing, co-promotion or other alliances within the United States.

It is possible that we might directly commercialize or co-promote droxidopa in IDH and other smaller potential therapeutic indications. Given the size of the fibromyalgia market, the vast sales forces required to compete in this market, and
the necessary infrastructure required, our marketing strategy in this indication is likely to include contracting with or licensing to third parties, particularly for territories outside the United States. Out-licensing arrangements might be
negotiated and entered into prior to droxidopa receiving marketing approval in one or more of the indications currently under clinical development

METABOLICALLY INERT ANTIFOLATES

Product Overview

Our portfolio of novel antifolate compounds was originally developed by Dr. M. Gopal Nair and licensed to us in 2004. A library of orally available
and metabolically inert antifolate compounds with potent autoimmune, anti-inflammatory and anti-tumor properties, these compounds are engineered to treat a broad range of immunological disorders with less harmful and unpleasant side effects than
those typically associated with classical antifolates such as methotrexate (MTX), currently the leading antifolate treatment and standard of care for a broad range of abnormal cell proliferation diseases.

Drug candidates from this portfolio, including both clinical candidates CH-1504 and CH-4051, inhibit dihydrofolate reductase, an enzyme required for cell
proliferation, but, due to the lack of metabolism, appear to be devoid of the toxicities related to the formation of metabolites which are believed to play a significant role in the liver and kidney toxicities associated with long-term use of MTX.

We believe these unique antifolates might have clinical advantages over MTX as they might have less toxicity and increased tolerability
while maintaining equal or potentially greater efficacy. Potential advantages over existing therapies, supported by our preclinical and clinical work to date, include:



| |  |  | higher response rate, including efficacy in patients that have failed MTX therapy;
| | - |  | ----------------------------------------------------------------------------------



| |  |  | faster onset of action;
| | - |  | -----------------------



| |  |  | better tolerability; and
| | - |  | ------------------------



| |  |  | superior toxicity profile.
| | - |  | --------------------------

Diseases
that may potentially be treated with metabolically inert antifolates include rheumatoid arthritis, psoriasis, inflammatory bowel disease, cancer and other immunological disorders.

Clinical Development

Our portfolio of metabolically inert antifolates currently consists of two
clinical stage drug candidates and additional preclinical candidates. CH-1504, the most advanced of our clinical stage antifolate compounds, is currently being developed for a lead indication in rheumatoid arthritis. CH-4051, the second clinical
stage compound in this portfolio, is the more potent enantiomer of CH-1504 and is being developed as a fast-follower to CH-1504 in rheumatoid arthritis.

Rheumatoid arthritis is a chronic inflammatory disease that leads to pain, stiffness, swelling and limitation in the motion and function of multiple joints. If left untreated, rheumatoid arthritis can produce serious
destruction of joints that frequently leads to permanent disability. Though the joints are the principal body part affected by rheumatoid arthritis, inflammation can develop in other organs as well. The disease currently affects over two million
Americans, almost 1% of the population, and is two to three times more prevalent in women. Onset can occur at any point in life with most patients developing the disease between the ages of 35 and 50.



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We believe that in rheumatoid arthritis patients, our novel antifolates might have significant clinical
advantages over MTX due to their metabolic stability. Because of this stability, it can be hypothesized that in those patients who are unresponsive to MTX, a metabolism-blocked antifolate might be clinically efficacious since it is not deactivated
by these enzymatic processes.

CH-1504

In June 2005, we commenced Phase I single and multiple dose escalation clinical trials of CH-1504 in healthy volunteers. These trials were conducted at Guys Hospital in London under the Clinical Trial Authorization, issued by the
Medicines and Healthcare Products Regulatory Agency, the United Kingdoms health authority. The in vivo portion and preliminary analysis of these trials were completed in December 2005.

Continuing evaluation of these results in light of additional preclinical data suggested that the bioavailability of CH-1504 was low and had significant
pharmacokinetic variability. Discussions among our personnel, external consultants and potential partners suggested the bioavailability of CH-1504 could be improved through standard alterations to the formulation. Consequently, we engaged in a
comprehensive screening of approximately 25 commercially viable salts and, based on the results of that screening process, selected a disodium salt of CH-1504 to take forward. Having selected a salt formulation, we initiated complimentary
pharmaceutical enhancements to the compound that include evaluation of various solid dosage form options. The primary goal of these formulation efforts was to improve the solubility of the compound, increasing bioavailability and reducing
pharmacokinetic variation of CH-1504. A formulation using gelucire to increase solubility was selected. Subsequent human bioequivalence studies showed 1.0 mg of the new formulation to be comparable to 15.0 mg of the original free acid formulation
and demonstrated an 11.4-fold improvement in relative bioavailability, as measured by area under the curve with an 8.9-fold increase in peak plasma levels (Cmax). Based on these studies, in January 2008 we initiated a Phase II proof of concept study
for CH-1504 in rheumatoid arthritis. Patient enrollment in this study was completed in the fourth quarter of 2008. The study is a multi-national, 12-week double-blind and randomized study in Russia, Ukraine, Poland and Canada with 200 MTX-naive
rheumatoid arthritis patients. The 4-arm trial includes a 0.25, 0.5 or 1.0 mg daily dose of CH-1504 versus a 20 mg weekly dose of MTX. Efficacy will be evaluated using standard ACR 20/50/70 scores. Tolerability will be evaluated in two
ways: Standard GI adverse events will be grouped and abnormal lab results from liver function tests will be tracked. In the fourth quarter of 2008, we received a positive recommendation from an independent data safety monitoring board, or DSMB, to
continue all arms of the trial in rheumatoid arthritis as planned based on interim safety data. Trial results are expected late in the first quarter of 2009.

CH-4051

In parallel to our clinical development of CH-1504, we continued additional preclinical evaluation of CH-1504,
including formulation work on the enantiomers of CH-1504. We then conducted studies to determine the relative potency of the L- and D-isomers. These studies suggested the L-isomer, now identified as CH-4051, was the more potent of the two thus
prompting additional preclinical evaluation of CH-4051.

In April 2008, we reported findings from a 17-day preclinical study of CH-4051
designed to test the efficacy of CH-4051 in a rat collagen-induced arthritis (CIA) model. The results reveal efficacy in delaying the onset of the disease, significantly decreasing the severity and, at certain doses, completely blocking all
development of rheumatoid arthritis (RA). The most significant finding from this study was that once daily dosing of 10mg/kg of CH-4051 administered from day 0 completely prevented the onset of arthritis. Similarly, twice daily 5mg/kg doses of
CH-4051 reduced the severity of disease in all animals and prevented disease onset in some. Both the once-daily dose of 10mg/kg and the twice-daily dose of 5mg/kg dose of CH-4051 demonstrated better prevention of disease than 0.25mg/kg of
methotrexate (a known MTD dose in this model) administered every three days.

In November 2008, we commenced a Phase I trial of CH-4051 in
healthy male volunteers. The randomized, double-blind placebo controlled study was designed to evaluate the safety, tolerability and pharmacokinetics of



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ascending doses of CH-4051 and conducted at Kendle Internationals Clinical Pharmacology Unit in the Netherlands. The single-ascending dose (SAD) study
included four cohorts of six healthy subjects with a 5:1 randomization. Dose escalation for each cohort was based on the safety and tolerability data from the previous cohort.

Following the SAD evaluation, the study progressed to a multiple ascending dose (MAD) evaluation and seeks to determine a maximum tolerated dose (MTD).
Though ultimately dependant on MTD, the MAD study is currently expected to evaluate four cohorts of eight subjects in a 6:2 randomization. Each cohort will be treated for 14 days and dose escalation will be based on the safety and tolerability data
from the previous cohort.

Other Potential Indications for our Antifolate Portfolio

As we proceed in our clinical development of our antifolate portfolio for rheumatoid arthritis, we expect to continue our evaluation of its potential in
other indications. Additional potential indications for our antifolates include psoriasis, inflammatory bowel disease, psoriatic arthritis and several different kinds of cancer. As our antifolates advance in rheumatoid arthritis and dose
tolerability studies, we will begin to focus on the timing of clinical programs for our antifolate compounds in these additional indications. Notwithstanding the foregoing, because of our limited funding, clinical studies will initially be pursued
in rheumatoid arthritis.

Antifolate Competition

There are many different drugs that are used to treat rheumatoid arthritis, including hormones, small molecules and biologics, which are manufactured using recombinant technology. The normal course of therapy for
rheumatoid arthritis begins with analgesics, such as aspirin, and non-steroidal anti-inflammatory agents, followed by disease modifying anti-rheumatic drugs (DMARDs), including low dose steroids, MTX, DHODH inhibitors and biologics, and, finally,
reconstructive joint surgery for patients failing all therapies. DMARDs are the only drugs that have been shown to alter the course of the disease.

Currently Available Antifolates. MTX, a classical antifolate, was originally used as a chemotherapy drug to treat certain kinds of cancer, but was also found to be beneficial in treating inflammatory arthritis and psoriasis. MTX is
generic and marketed in both injectable and oral formulations by multiple companies including Barr Laboratories, Boehringer Ingelheim Pharma, Mayne Pharma and Mylan Laboratories.

Currently Available Biologics. Although there have been positive results for biologics, we
believe physicians are likely to reserve anti-tumor necrosis factor (anti-TNF) and other biologic therapies for patients who have failed or had a limited response to initial MTX monotherapy. Despite increased aggressiveness of treating physicians
and easier reimbursement, front line use with biologics either in monotherapy or in combination with MTX is unlikely to occur due to their high costs and side effect profile. Enbrel®,
Humira® and Remicade® are TNF blockers that have been approved by the FDA over the last six years and are the top selling
biologics for rheumatoid arthritis. These three TNF blockers are administered to patients by injection and can be used alone or in combination with other DMARDs or NSAIDs such as aspirin or ibuprofen. Enbrel®, which is developed by Amgen, is the top selling biologic for rheumatoid arthritis, and is also indicated for juvenile rheumatoid arthritis, early rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis.
Enbrel® had global sales of $2.9 billion in 2006. Remicade® is a chimeric anti-TNF monoclonal antibody developed by
Johnson & Johnson for the treatment of rheumatoid arthritis and Crohns disease with combined global sales of $3.0 billion in 2006. Abbott Laboratories Humira® had 2007
global sales of $3.0 billion. Both Remicade® and Humira® contain black box warnings for tuberculosis. Rituxan is currently
marketed by Genetech and Roche for rheumatoid arthritis in patients refractory to other DMARD therapy. Orencia® (abatacept), developed by Bristol-Myers Squibb, is being studied as a
once-monthly infusion for rheumatoid arthritis. The drug has been recently approved by the FDA and earlier data, as reported by Bristol-Myers Squibb, has shown the drug to be safe as a monotherapy and combination.



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DMARDs in Development.Rigel
Pharmaceuticals R788 showed proof of concept in a Phase II Clinical Trial in rheumatoid arthritis as announced during 2007 and is currently being studied in Phase IIb trials. An oral syk kinase inhibitor, R788 (tamatinib fosdium)
demonstrated statistically significant results in treating rheumatoid arthritis patients. We believe that with significant ACR scores and good tolerability as observed in this clinical trial, and with the benefit of oral delivery, R788 may be a
favorable alternative to the currently approved biological agents. However we anticipate that, like other biologics, this compound would work best in combination with MTX and should not significantly impact the opportunity available to our
antifolate portfolio. UCB Celltech is currently developing Cimzia®, a pegylated anti-TNF antibody for the treatment of rheumatoid arthritis. Cimzia® has been approved in the United States and Switzerland for the treatment of Crohns disease and is under active review in the United States and the European Union for the treatment of RA.

Antifolate Marketing

Given the size of the
rheumatoid arthritis market, the vast sales forces required to compete in this market, and the necessary infrastructure required, our marketing strategy for CH-1504 is likely to include contracting with or licensing to third parties, particularly
for territories outside the United States. It is possible that we might directly commercialize or co-promote this or another of our antifolate compounds in the smaller therapeutic indications such as psoriasis or irritable bowel disease.
Out-licensing arrangements might be negotiated and entered into prior to one or more of our antifolate drug candidates being approved for marketing.

I-3D PORTFOLIO

Overview

In May of 2006, we signed an agreement with Active Biotech AB for the co-development and commercialization of the I-3D portfolio, a group of orally active compounds that inhibit the enzyme dihydroorotate dehydrogenase (DHODH) for the
treatment of autoimmune diseases and transplant rejection. At the time of the agreement, Active Biotech had already isolated more than 15 compounds and conducted extensive preclinical modeling resulting in the identification of two potential lead
compounds.

Having previously demonstrated proof of concept in both rheumatoid
arthritis and transplant rejection in animal models, the joint development committee selected AB-224050 as the first I-3D compound to undergo IND-enabling toxicology studies during the third quarter of 2006. As part of the ongoing evaluation and
preparation for Phase I trials, the joint development committee initiated a Phase 0 (micro-dosing) study to evaluate the half-life of AB-224050 in humans in the first quarter of 2007. Based on the results of the micro-dosing study and other ongoing
preclinical activity, it has now been determined that, while demonstrating a significantly shorter half-life than Arava®, AB-224050 will require additional work prior to the commencement of
Phase I clinical trials. In 2007, the joint development committee continued preclinical optimization of AB-224050 and conducted further comparisons of AB-224050 versus other compounds in the I-3D.

In April 2008, following a decision to focus its resources on its immunomodulatory compounds, Active Biotech AB discontinued its participation in the
I-3D co-development program and granted us exclusive global rights to the portfolio in exchange for royalties on future sales.

I-3D Additional
Indications

In addition to therapeutic applications in rheumatoid arthritis, compounds from the I-3D portfolio are believed to have
broad clinical application in immune-mediated inflammatory disorders including transplant rejection, psoriasis and systemic lupus erythematosus.

I-3D
Competition

As discussed in conjunction with our antifolate program, there are many different drugs that are used to treat rheumatoid
arthritis, including hormones, small molecules and biologics, which are manufactured using recombinant



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technology. The normal course of therapy for rheumatoid arthritis begins with analgesics, such as aspirin, and non-steroidal anti-inflammatory agents,
followed by disease modifying anti-rheumatic drugs or DMARDs, including MTX, DHODH inhibitors, low dose steroids and biologics, and, finally, reconstructive joint surgery for patients failing all therapies. DMARDs are the only drugs that have been
shown to alter the course of disease.

Leflunomide(Arava®),first marketed in 1998 as an oral DMARD for the treatment of rheumatoid arthritis, is a cytotoxic that is believed to work by inhibiting the DHODH enzyme to prevent DNA synthesis and
limit abnormal cell proliferation. Leflunomide is known to have a half-life of greater than two weeks. Given the length of time required to reach therapeutic levels, a higher dose (loading dose) is initially required before dropping down to a lower
maintenance dose. Side effects include diarrhea (27%), dyspepsia (10%) abdominal pain (5%), or nausea (13%) and altered liver function (10%).

I-3D Marketing

Given the size of the rheumatoid arthritis market, the vast sales forces required to compete in that market,
and the necessary infrastructure required, our marketing strategy for I-3D compounds would likely be similar to that of our strategy for our antifolates and may include contracting with or licensing to third parties. It is possible that, at some
point, we might co-promote in the larger therapeutic markets such as rheumatoid arthritis or market I-3D compounds on our own accord for indications other than rheumatoid arthritis. Any such arrangements might be negotiated and entered into prior to
one or more of our I-3D drug candidates being approved for marketing.

Scientific Advisory Boards

We retain the services of certain qualified individuals on our Scientific Advisory Boards which normally meet at least yearly. Meetings or consultations
with Scientific Advisory Board members are held more often when significant developments arise or new information becomes available that require expert review. The boards provide an opportunity to review our scientific, research and clinical
development plans from the perspective of experts and key opinion leaders in the medical community. Specifically, the Scientific Advisory Boards provide advice concerning the design of clinical research protocols to be utilize for the development of
our drug candidates and they provide an opportunity to test the validity of our assumptions regarding the attitudes of the medical community relative to various drug characteristics that might be highlighted during development.

Our Scientific Advisory Board for NOH consists of the following individuals:

Horacio Kaufmann, MDis currently the F.B. Axelrod Professor of Neurology and Professor of Medicine and Pediatrics at the New York University
School of Medicine. He is the director of the Dysautonomia Research Laboratory at the New York University Medical Center. Dr. Kaufmann is the past President of the American Autonomic Society, former Chairman of the Autonomic Nervous System Section
of World Federation of Neurology and the American Academy of Neurology and co-Editor-in-Chief of Clinical Autonomic Research. He is a world renowned expert in the treatment of autonomic disorders, autonomic physiology and pathophysiology. Dr.
Kaufmann has published extensively in the medical literature, particularly on the treatment of orthostatic hypotension in neurodegenerative disorders, such as Parkinsons disease and multiple system atrophy. His research on autonomic disorders
has been funded by the National Aeronautics and Space Administration, the National Institute of Health, National Organization of Rare Disorders, the DANA foundation and the Dysautonomia Foundation.

Roy Freeman, MD is Professor of Neurology at Harvard Medical School and director of the Center for Autonomic and Peripheral Nerve Disorders in the
Department of Neurology at Beth Israel Deaconess Medical Center in Boston, Massachusetts. Dr. Freemans clinical and research expertise is in the physiology and pathophysiology of the autonomic nervous system and small nerve fibers. He is
also an authority on the neurological complications of diabetes, the autonomic complications of Parkinsons disease and multiple system atrophy, the diagnosis and treatment of autonomic and peripheral nervous system disorders and neuropathic
pain. Dr. Freeman is widely published in these research areas.



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Phillip Low, MD is past chairman of the division of neurophysiology at the Mayo Clinic in
Rochester, Minnesota. He is founder and director of the Autonomic Laboratory which evaluates autonomic function. He serves as director of the Mayo Autonomic Disorders Project, the first program grant for autonomic disorders to be funded by the
National Institutes of Health. His research is focused on studies of the pathophysiology of orthostatic intolerance and its amelioration. Diseases studied include multiple system atrophy, autoimmune autonomic neuropathy and postural tachycardia
syndrome. Dr. Low is Associate Editor of the journal Autonomic Neuroscience. He also serves on the editorial board of numerous publications including Muscle & Nerve, Autonomic Neuroscience, Journal of Clinical Neurophysiology and
Journal of Clinical Neuromuscular Diseases. He also serves on the scientific advisory board of the Neuropathy Association and is a member of the steering committee NIDDK/NHLBI Animal Models of Diabetic Complications Neuropathy Disease Validation
Committee.

Peter LeWitt, MD is Professor of Neurology and Psychiatry at Wayne State University School of Medicine in Detroit,
Michigan. He is a specialist in Parkinsons disease and other movement disorders and also directs a laboratory research program investigating neurochemical mechanisms and diagnostic markers in Parkinsons and Alzheimers diseases. He
has served as a scientific review consultant for the National Institutes of Health and the Veterans Administration. Other advisory affiliations with national organizations include the International Essential Tremor Foundation and the National
Parkinson Foundation. Dr. LeWitt further serves as president of the Michigan Parkinson Foundation. He has been a steering committee member and clinical investigator for the Parkinson Study Group and other clinical trials research consortia.
Dr. LeWitt is editor-in-chief of Clinical Neuropharmacology and also serves on the editorial board of the Journal of Neural Transmission.

Italo Biaggioni, MDis Professor of Medicine and Pharmacology and the Associate Director of the General Clinical Research Center, which he developed, at Vanderbilt University in Nashville, Tennessee. With over 25 years of experience
in biomedical research in general and clinical research in particular, the focus of Dr. Biaggionis clinical research is the interaction between neural (autonomic) and metabolic (adenosine, nitric oxide) factors that regulate blood
pressure. His basic research focuses on the role of adenosine receptors in disease processes and their target for drug development. He has had 20 years of continuous funding from the National Institute of Health, over 200 publications in
peer-reviewed journals, and is on the editorial board of several journals including Hypertension, Journal of Pharmacology and Experimental Therapeutics, Journal of Applied Physiology and Clinical Autonomic Research. He is a founding member of
the American Autonomic Society and served as its President from 2006 to 2008.

Our Scientific Advisory Board for rheumatology
consists of the following individuals:

Lee Simon, M.D.is an Associate Professor of Medicine at the Harvard School of Medicine and
also on staff at the New England Baptist Hospital and Beth Israel Deaconess Medical Centre. He has been a rheumatologist for 25 years and is a fellow of the American College of Physicians and the American College of Rheumatology. Dr. Simon
received his M.D. from the University of Maryland, completed his internship and residency in internal medicine at the Johns Hopkins Hospital, and trained in the arthritis unit of the Massachusetts General Hospital and Harvard Medical School. In
addition to his many academic appointments, Dr. Simon has been a consultant to and a senior member of the FDA where he served as Division Director for analgesic, anti-inflammatory and ophthalmologic drug products. Dr. Simon has served on
the editorial boards of multiple journals, has authored more than 110 original publications, review articles, and chapters, and has served as an editor of four books.

Vibeke Strand, M.D. is an Adjunct Clinical Professor in the Division of Immunology and Rheumatology at Stanford University School of Medicine. Dr. Strand earned her M.D. at the University of California San
Francisco School of Medicine. She completed a residency in Internal Medicine at Michigan State and a Fellowship in Rheumatology/Immunology at the University of California San Francisco School of Medicine. Dr. Strand has been an invited speaker
at FDA Arthritis Advisory Committee meetings discussing Guidance Documents for various topics from 1996 through 2003. She has authored over 100 articles and 25 chapters, and has co-edited several books.



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Arthur F. Kavanaugh, M.D. is a Professor of Medicine at the University of California, San Diego
(UCSD) School of Medicine. In addition, he is the Director of the Center for Innovative Therapy of the UCSD Division of Rheumatology, Allergy, and Immunology. Dr. Kavanaugh earned his BS in biology at the Massachusetts Institute of Technology
in Cambridge, Massachusetts and his M.D. at Saint Louis University School of Medicine in Saint Louis, Missouri. He completed a residency in Internal Medicine and then a fellowship in Clinical Immunology/Allergy at the Baylor College of Medicine in
Houston, Texas. Dr. Kavanaugh also completed a Rheumatology fellowship at the University of Texas Southwestern Medical School in Dallas. Dr. Kavanaugh has authored more than 120 scientific publications and book chapters. He is on the
editorial board for several journals, and has served as peer reviewer for more than a dozen scientific journals. Dr Kavanaugh is a fellow of the American Academy of Allergy, Asthma, and Immunology, and the American College of Rheumatology, or ACR.
He has been a member of and chaired a number of committees in these organizations.

Joel M. Kremer, M.D. is a Professor of Medicine
at the Albany Medical College and is also Director of Research at The Center for Rheumatology in Albany. Dr. Kremer earned his M.D. from Temple University School of Medicine and trained in Internal Medicine and Rheumatology at Albany Medical
College. He has worked extensively with methotrexate and combinations of new agents with methotrexate. Dr. Kremer is the recipient of the Engalaticheff Award given by The Arthritis Foundation for contributions which improve the quality of
life of patients with arthritis in 1997. He is the author of approximately 100 peer-reviewed publications, 16 chapters and six texts. He is president and founder of CORRONA, a research organization which gathers data from rheumatologists and
patients throughout the United States.

Stanley B. Cohen, M.D. is a Clinical Professor in the Department of Internal Medicine at
Southwestern Medical School and in private practice at Rheumatology Associates in Dallas, Texas. He is also Clinical Attending for the Internal Medicine Residency Program and Associate Director of the Arthritis Division at St. Paul Medical Center;
Director of the Osteoporosis Center at Baylor Irving Hospital; and Medical Director of Radiant Research Dallas. Dr. Cohen received his M.D. from the University of Alabama School of Medicine and completed an internship and residency in internal
medicine at Parkland Memorial Hospital in Dallas. He received his fellowship in rheumatology from St. Paul Medical Center/Southwestern Medical School. Dr. Cohens current professional appointments also include serving as a Member of the
Board of the ACR, the Medical Advisory Board of Directors of the Harold C. Simmons Arthritis Center at Southwestern Medical School and member of the UTSWMC CME Executive Committee. Dr. Cohen is a co-editor of the monograph The
Spondyloarthropathies, Advances in Inflammation Researchand author or coauthor of book chapters, articles and abstracts that have been published in many leading journals and presented at national and international medical and scientific
symposia. He has been the recipient of numerous awards and honors including the AF Medical Profession Award.

Edward C. Keystone,
M.D. is a Professor of Medicine at the University of Toronto and a Senior Consultant in Rheumatology at Mount Sinai Hospital. Dr. Keystone recently established The Rebecca Macdonald Centre for Arthritis and Autoimmune Disease, which is
devoted to research into genomics, therapeutics, and outcomes in autoimmune inflammatory joint disease. Dr. Keystone obtained his M.D. and specialty degrees and fellowships in both Rheumatology and Internal Medicine from the University of
Toronto. He then carried out his research training at the Clinical Research Centre in Harrow, London, United Kingdom. He was on staff as a consultant rheumatologist at The Wellesley Central Hospital, Toronto from 1976 to 1998. He is the author of
more than 145 peer-reviewed papers, reviews and book chapters, and has been the recipient of numerous teaching awards and honors, including the Senior Investigator Award of the Canadian Rheumatology Association.

William Schwieterman, M.D.is a board-certified internist and rheumatologist who currently works as an independent consultant for biotech and
pharmaceutical companies. Dr. Schwieterman received his M.D. from the University of Cincinnati and his internship and residency programs were completed at Mt. Sinai Hospital in New York City. Dr. Schwietermans research training was
obtained at the National Institutes of Health in Bethesda, Maryland. He subsequently joined the FDA in the Centre for Biologics as Chief of the Medicine Branch, and then as Chief of the Immunology and Infectious Disease Branch in the Division of
Clinical Trials in CBER, where he worked with sponsors for the development of new agents for pulmonary medicine, neurology, sepsis,



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hepatitis, rheumatology, infectious disease, solid organ transplantation and wound-healing, among other areas. Dr. Schwieterman is widely published in
peer-reviewed journals, in addition to having helped author the FDAs Good Review Practices for investigational products. While continuing to participate on our scientific advisory board, in June 2008, Dr. Schwieterman also joined our
Board of Directors.

Government Regulation

The FDA and foreign regulatory agencies regulate many aspects of product development and marketing of our product candidates including research, development, manufacture, labeling, promotion, advertising, distribution, and marketing.
Meeting the various US and international regulatory requirements often takes several years, and the actual time required can vary substantially based upon the type, complexity and novelty of the pharmaceutical product and the therapeutic indication.
Furthermore, meeting the regulatory requirements as well as maintaining compliance often necessitates implementing costly procedures. Failure to comply with the applicable requirements mandated by the FDA and other regulatory agencies can result in
administrative or judicial sanctions. In the United States, such sanction may include the FDAs refusal to approve pending NDAs, warning letters, product recalls, product seizures, total or partial suspension of production or distribution,
injunctions and/or criminal prosecution.

Success in preclinical or early-stage clinical trials does not ensure success in late-stage
clinical trials. Data obtained from preclinical and early stage clinical activities are not always conclusive and are susceptible to varying interpretations that could negatively impact our trials and delay, limit or prevent regulatory approval. In
addition, we cannot be certain that the FDA or any other international regulatory agency will grant approval for any of our products under development on a timely basis, if at all. Delays in obtaining, or failures to obtain, regulatory approvals
would have a material adverse effect on our business. Even if a product receives regulatory approval, the approval might be significantly limited to specific indications or uses. After regulatory approval is obtained and the product becomes
available on the market, the later discovery, over time, of previously unknown problems with a product might result in restrictions on the product or even complete withdrawal of the product from the market.

Drug Approval Process in the United States

In the
United States, the FDA regulates drugs under the Federal Food, Drug, and Cosmetic Act, or FDCA, and those regulations are published in the Federal Register. None of our drugs may be marketed in the United States until the drug has received FDA
approval. The process required before a drug can be marketed in the United States includes:



| |  |  | preclinical laboratory tests, animal pharmacology and toxicology studies, and formulation studies;
| | - |  | --------------------------------------------------------------------------------------------------



| |  |  | submission to the FDA of an investigational new drug application, or IND, for human clinical testing, which must be cleared by the FDA before human clinical trials
can begin in the United States;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | adequate and well-controlled human clinical trials to establish the safety and efficacy of the drug for each indication;
| | - |  | ------------------------------------------------------------------------------------------------------------------------



| |  |  | submission to the FDA of an NDA;
| | - |  | --------------------------------



| |  |  | satisfactory completion of an FDA inspection of the manufacturing facility or facilities at which the drug is produced to assess compliance with current good
manufacturing practices, or cGMPs; and
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | FDA review and approval of the NDA.
| | - |  | -----------------------------------

Preclinical tests include laboratory tests and animal studies. The conduct of the preclinical tests as well as the formulation of the compounds must comply with FDA regulations. The preclinical test data, together with manufacturing
information and analytical data of product chemistry, are submitted to the FDA as part of an IND, which must become effective before human clinical trials can begin. An IND will automatically become effective 30 days after receipt by the FDA, unless
before that time the FDA raises concerns or questions regarding the clinical trials as outlined in the IND. In such a case, the IND sponsor and the FDA must resolve any outstanding



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FDA concerns or questions before clinical trials can proceed. Within the 30 day period, the FDA may put a clinical hold on the IND. We cannot be certain that
submission of an IND will result in clearance by the FDA to allow clinical trials to begin.

Clinical trials involve the administration of
the investigational drug to human subjects under the supervision of qualified clinical investigators. Clinical trials are conducted under protocols detailing the objectives of the study, the parameters to be used in monitoring safety, and the
effectiveness criteria to be evaluated. Each clinical trial protocol must be submitted to the FDA as part of the IND.

Clinical trials
typically are conducted in three sequential phases, but the phases might overlap. The study protocol and informed consent information for study subjects in clinical trials must also be approved by an Institutional Review Board for each institution
where the trials will be conducted. Study subjects must sign an informed consent form before participating in a clinical trial. The normal clinical trial phases are:



| |  |  | Phase I usually involves the initial introduction of the investigational drug into healthy volunteers to evaluate its short-term safety, dosage tolerance,
metabolism, pharmacokinetics and pharmacologic actions, and, if possible, to gain an early indication of its effectiveness.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Phase II usually involves trials in a small patient population to evaluate dosage tolerance and appropriate dosage, identify possible adverse effects and safety
risks, and evaluate preliminarily the efficacy of the drug for specific indications.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Phase III trials usually involve further evaluation of clinical safety and efficacy by using the drug in its final form in a larger patient population. There can be
no assurance that phase I, phase II, or phase III testing will be completed successfully within any specified period of time, if at all. Furthermore, clinical trials might be suspended by us or the FDA at any time on various grounds, including a
finding that the subjects or patients are being exposed to an unacceptable health risk.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Once the required clinical
testing is successfully completed, the results of the preclinical studies and of the clinical studies, as well as information on the manufacture and composition of the drug, are submitted to the FDA in a NDA. If the FDA grants NDA approval, the
product can then be marketed for one or more indications. On the other hand, if the FDA reviews the application and deems it to be inadequate to support the NDA approval, and hence, marketing approval, we cannot ensure that any approval will be
granted on a timely basis, if at all. The FDA might also refer the application to the appropriate advisory committee, typically a panel of clinicians and scientists, for review, evaluation and a recommendation as to whether the application should be
approved. The FDA is not bound by the recommendations of the advisory committee.

The overall drug development process, including
preclinical testing, clinical trials through to marketing approval requires substantial time, effort and financial resources.

The FDA has
various programs, including fast track, priority review, and accelerated approval, that are intended to expedite or simplify the process for reviewing drugs, and/or provide for approval on the basis of surrogate endpoints. Generally, drugs that
might be eligible for one or more of these programs are those for serious or life-threatening conditions, those with the potential to address unmet medical needs, and those that provide meaningful benefit over existing treatments. We cannot ensure
that any of our drugs will qualify for any of these programs, or that, if a drug does qualify, that the review time will be reduced.

Section 505b2 of the FDCA allows the FDA to approve a follow-on drug on the basis of data in the scientific literature or data used by FDA in the approval of other drugs. This procedure potentially makes it easier for generic drug
manufacturers to obtain rapid approval of new forms of drugs based on proprietary data of the original drug manufacturer.

Before approving
an NDA, the FDA usually will inspect the facility or the facilities at which the drug is manufactured, and will not approve the product unless the manufacturing site is cGMP-compliant. If the FDA



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evaluates the NDA and the manufacturing facilities as acceptable, the FDA might issue an approval letter, or in some cases, an approvable letter followed by
an approval letter. Both letters usually contain a number of conditions that must be met in order to secure final approval of the NDA. When and if those conditions have been met to the FDAs satisfaction, the FDA will issue an approval letter.
The approval letter authorizes commercial marketing of the drug for specific indications. As a condition of NDA approval, the FDA might require post-marketing testing and surveillance to monitor the drugs safety or efficacy, or they may impose
other conditions.

After approval, certain changes to the approved product, such as adding new indications, making certain manufacturing
changes, or making certain additional labeling claims, are subject to further FDA review and approval. Before we can market our product candidates for additional indications, we must obtain additional approvals from the FDA. Obtaining approval for a
new indication generally requires that additional clinical studies be conducted. We cannot ensure that any additional approval for new indications for any product candidate will be approved on a timely basis, or at all.

Post-Approval Requirements

Often, even after a drug
has been approved by the FDA for sale, the FDA might require that certain post-approval requirements be satisfied, including the conduct of additional clinical studies. If such post-approval conditions are not satisfied, the FDA might withdraw its
approval of the drug. In addition, holders of an approved NDA are required to:



| |  |  | report certain adverse reactions to the FDA;
| | - |  | --------------------------------------------



| |  |  | comply with certain requirements concerning advertising and promotional labeling for their products; and
| | - |  | --------------------------------------------------------------------------------------------------------



| |  |  | continue to have quality control and manufacturing procedures conform to cGMP after approval.
| | - |  | ---------------------------------------------------------------------------------------------

The FDA periodically inspects the sponsors records related to safety reporting and/or manufacturing facilities, including an assessment of
compliance with cGMP. Accordingly, manufacturers must continue to expend time, money, and effort in the area of production and quality control to maintain cGMP compliance. We intend to use third party manufacturers to produce our products in
clinical and commercial quantities, and future FDA inspections might identify compliance issues at the facilities of our contract manufacturers that might disrupt production or distribution, or require substantial resources to correct. In addition,
discovery of problems with a product after approval might result in restrictions on a product, manufacturer, or holder of an approved NDA, including withdrawal of the product from the market.

Orphan Drug Designations

The FDA can grant orphan
drug designation to drugs intended to treat a rare disease or condition, which generally is a disease or condition that affects fewer than 200,000 individuals in the United States. Orphan drug designation must be requested before
submitting an NDA. If the FDA grants orphan drug designation, which it might not, the identity of the therapeutic agent and its potential orphan use are publicly disclosed by the FDA. Orphan drug designation does not necessarily convey an advantage
in, or shorten the duration of, the review and approval process. If a product which has an orphan drug designation subsequently receives the first FDA approval for the indication for which it has such designation, the product is entitled to orphan
exclusivity, meaning that the FDA will not approve any other applications to market the same drug for the same indication, except in certain very limited circumstances, for a period of seven years. Orphan drug designation does not prevent
competitors from developing or marketing different drugs for that indication.

Regulations Outside the United States

Before our products can be marketed outside of the United States, they are subject to regulatory approval similar to that required in the United States,
although the requirements governing the conduct of clinical trials,



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including additional clinical trials that might be required, product licensing, pricing and reimbursement vary widely from country to country. No action can
be taken to market any product in a country until an appropriate application has been approved by the regulatory authorities in that country. The current approval process varies from country to country, and the time spent in gaining approval varies
from that required for FDA approval. In certain countries, the sales price of a product must also be approved. The pricing review period often begins after market approval is granted. Even if a product is approved by a regulatory authority,
satisfactory prices might not be approved for such product.

In Europe, marketing authorizations may be submitted via a centralized, or
decentralized (or national level) approach. The centralized procedure is mandatory for the approval of biotechnology products and provides for the grant of a single marketing authorization that is valid in all European Union member states. As of
January 1995, a mutual recognition procedure is available at the request of the applicant for all medicinal products that are not subject to the centralized procedure. There can be no assurance that the chosen regulatory strategy will secure
regulatory approvals on a timely basis or at all.

Manufacturing

We own no manufacturing facilities, quality control laboratories or warehouses for storage and distribution. We use third-party contractors for manufacturing drug substances under development. We also use contractors
for preformulation, formulation and analytical development as well as manufacturing of drug products used for clinical studies. If any of our products are approved by the FDA for marketing, we plan to use third-party contractors for producing the
commercial product. This strategy enables us to direct our financial resources to product development without devoting resources to the time and costs associated with building manufacturing plants and laboratories. We plan on implementing this
strategy for the foreseeable future.

Intellectual Property

We actively seek to obtain, maintain and enforce patent protection for our products, formulations, processes, methods and other proprietary technologies, preserve our trade secrets, and operate without infringing on
the proprietary rights of other parties, both in the United States and in other key markets. Our goal is to obtain, where appropriate, the broadest intellectual property protection possible for our current product candidates, including CH-1504,
CH-4051 and droxidopa, and any future product candidates and proprietary technologies through a combination of contractual arrangements and patents, both in the United States and other countries.

As of February 2009, our patent estate for the antifolate portfolio, including CH-1504 and CH-4051, includes one issued U.S. patent, five pending U.S.
patent applications, a pending Patent Cooperation Treaty (PCT) patent application and several related patent applications pending in countries outside the United States, including Europe and Japan. The issued U.S. patent is U.S. Patent
No. 5,912,251, issued June 15, 1999 and entitled Metabolically Inert Anti-Inflammatory and Anti-Tumor Antifolates. Two of the first pending U.S. patent applications are published as US 2006-0111272 and US 2008-0214585 and the
remainder are unpublished provisional patent applications. The pending applications are directed to compositions and certain new antifolate compounds.

The issued U.S. patent covers our current product candidates, CH-1504 and CH-4051, as well as certain analogues, including claims to these compounds as compositions of matter, in pharmaceutical formulations and for
use in treatment of certain diseases. The pending U.S. patent applications and international applications expand our proprietary position, claiming additional compounds and their uses as well as new uses of CH-1504. We plan to continue to strengthen
our patent estate on our antifolate portfolio by filing and pursuing additional patents.

Our patent estate for droxidopa includes six
pending U.S. patent applications, three PCT patent applications and a pending European application, which are directed to pharmaceutical compositions comprising droxidopa and therapeutic methods of treatment using droxidopa. We plan to continue to
strengthen our patent estate on droxidopa by filing and pursuing additional patents.



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The patent estate for the I-3D portfolio includes U.S. Patent No. 7,074,831, issued July 11,
2006, a pending PCT application and a number of related patent applications pending in countries outside the United States. We plan to continue to strengthen our patent estate on the I-3D portfolio by filing and pursuing additional patents.

Our success also depends upon the skills, knowledge and experience of our scientific and technical personnel, our consultants and
advisors, as well as our licensors and contractors. To help protect our proprietary know-how and our inventions for which patents are unobtainable or difficult to obtain, we rely on trade secret protection and confidentiality agreements. To this
end, it is our policy to require all of our employees, consultants, advisors and contractors to enter into agreements that prohibit the disclosure of confidential information and, where applicable, require disclosure and assignment to us of the
ideas, developments, discoveries and inventions important to our business.

Employees

We have attracted and retained a management team with core competencies and expertise in numerous fields, including manufacturing, research, clinical,
regulatory and business development. Our management and advisors are comprised of experienced pharmaceutical and biotechnology industry veterans and respected experts. We are led by our Chief Executive Officer, Dr. Simon Pedder, formerly Vice
President, Pharmaceutical Business, Oncology at Hoffmann-La Roche Inc., who has over 20 years of senior pharmaceutical management experience, including drug development and business experience. During this time at Roche, Dr. Pedder was
responsible for a number of global development programs, successful registrations and product launches.

We have a total of 17 employees.
We believe the relationships with our employees are satisfactory. We anticipate that we will need to identify, attract, train and retain other highly skilled personnel. Hiring for such personnel is competitive, and there can be no assurance that we
will be able to retain our key employees or attract, assimilate or retain the qualified personnel necessary for the development of our business.

Where
you can find additional information

Our website address is www.chelseatherapeutics.com. We make available free of charge through our
website our annual report on Form 10-K, quarterly reports on Form 10-Q, current reports on Form 8-K, and all amendments to those reports as soon as reasonably practicable after such material is electronically filed with or furnished
to the SEC.

Executive Officers of the Registrant

The following table sets forth the name, age and position of each of our executive officers as of March 3, 2009.



|                 |  |     |  |                                                           
|---------------- |  | --- |  | ----------------------------------------------------------
|Name             |  | Age |  | Position                                                  
|Simon Pedder     |  | 48  |  | President, Chief Executive Officer and Director           
|J. Nick Riehle   |  | 56  |  | Vice President, Administration and Chief Financial Officer
|L. Arthur Hewitt |  | 55  |  | Vice President, Drug Development                          
|Keith Schmidt    |  | 58  |  | Vice President, Sales and Marketing                       
|Joseph Oliveto   |  | 41  |  | Vice President, Operations                                

Simon Pedder, Ph.D.President, Chief Executive Officer and Director.Dr. Pedder
joined us from Hoffmann-La Roche Inc. in April 2004 where he was Vice President of Pharmaceutical Business, Oncology and an executive officer since February 2003. Prior to that he served as the Vice President, Drug Development at Shearwater
Corporation from May 2001 until December 2002. Prior to that Dr. Pedder served in a number of positions at Hoffmann-La Roche, including as Director, Pharmaceutical Business, Pharmaceutical Development and Project Management from May 1994 until
May 2001. While at Hoffmann-La Roche, Dr. Pedder was in



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charge of the development of Pegasys and Copegus, which have combined annual worldwide sales of over $1 billion, and oversaw a number of successful NDAs.
Dr. Pedder has his Ph.D. in Pharmacology from the College of Medicine at the University of Saskatchewan in Canada.

J. Nick Riehle,
MBAVice President, Administration and Chief Financial Officer.Mr. Riehle has been our Vice President, Administration and Chief Financial Officer since July 2004. Prior to that he served as Chief Financial Officer at HAHT Commerce,
Inc., a software company, from August 1996 until June 2003 and as an independent contractor from July 2003 until July 2004. Prior to that, Mr. Riehle served in various roles at Nortel Networks and IBM. Mr. Riehle has his Bachelor of
Commerce from McGill University, his MBA from York University and earned a Certified Management Accountant (CMA) designation from Ontario, Canada.

L. Arthur Hewitt, Ph.D.Vice President, Drug Development.Dr. Hewitt has been our Vice President, Drug Development since May 2004. Prior to that he served as an independent contractor from January 2003 to May 2004, as
Director of Scientific Affairs at Shearwater Corporation, a drug delivery company, from October 2002 until January 2003 and as Director of Scientific Affairs for Amgen Canada from July 1991 until November 2000. During his years at Amgen,
Dr. Hewitt oversaw the approval of Neupogen, Stemgen and Infergen. Dr. Hewitt obtained his Ph.D. in Pharmacology from the Medical School at the University of Montreal.

Keith SchmidtVice President, Marketing and Sales.Mr. Schmidt has served as our Vice President, Marketing and Sales since July 2006. In
February 2007, Mr. Schmidt became one of our executive officers. Prior to that he was President of his biotech consulting company, Tellico Pharma LLC from June 2005 and served as Vice President of Thomson Healthcare Advanced Therapeutics
Communications, a medical education company, from February 2002 until May 2005. From 1996 until January 2002, Mr. Schmidt served as an International Business Leader for Hoffmann-La Roche where he developed and led the global sales and marketing
launch efforts for Pegasys and Copegus. Mr. Schmidt earned a Bachelor of Science from South Dakota State University and an MBA from the University of San Francisco.

Joseph OlivetoVice President, Operations. Mr. Oliveto joined us in June 2008 following a two-year assignment as Executive in Residence at Pappas Ventures, a life sciences venture capital firm. Prior
to Pappas Ventures, he served in a number of progressively senior positions at Hoffmann-La Roche, most recently as the Global Alliance Director for Roches licensing organization. Previous experience at Roche includes clinical development,
project management, manufacturing process improvement and global business. During his tenure, he played an integral part in the success of multiple NDA filings, developed comprehensive launch programs, including those for both Pegasys and Copegus,
and closed multiple licensing deals. Mr. Oliveto obtained a BA in Chemistry and an MBA from Rutgers University.



|ITEM 1A. | RISK FACTORS
|-------- | ------------

This report contains forward-looking
statements that involve risks and uncertainties. Our actual results could differ materially from those discussed in this report. Factors that could cause or contribute to these differences include, but are not limited to, those discussed below and
elsewhere in this report and in any documents incorporated in this report by reference.

We currently have no product revenue and will need to raise
additional capital to operate our business.

To date, we have generated no product revenue. Until, and unless, we receive approval from
the FDA and other regulatory authorities for our product candidates, we cannot sell our drugs and will not have product revenue. Currently, our primary product candidates are droxidopa and our antifolates portfolio, and none are approved by the FDA
nor, with the exception of droxidopa which has Japanese approval, any other regulatory agency for sale. Therefore, for the foreseeable future, we will have to fund all of our operations and development expenditures, including anticipated 2009
expenses of at least $30 million, from cash on hand, redemptions of or borrowings against investments, other equity or debt financings, licensing fees and grants. In addition, as a result



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of our financial position as of December 31, 2008, the audit opinion received from our independent auditors, which is included in our financial statements in
this report, contained a notation related to our ability to continue as a going concern.

In order to fund operations and increase our cash
reserves in 2009, we may seek to outlicense our products or seek additional sources of financing and such opportunities might not be available on favorable terms, if at all. If we do not succeed in raising additional funds on acceptable terms, we
might not be able to complete planned preclinical and clinical trials or obtain approval of any product candidates from the FDA and other regulatory authorities. In addition, we could be forced to discontinue product development, reduce or forego
sales and marketing efforts, forego attractive business opportunities or curtail operations. Any additional sources of financing could involve the issuance of our equity securities, which would have a dilutive effect on our stockholders.

We are not currently profitable and might never become profitable.

We have a history of losses and expect to incur substantial losses and negative operating cash flow for the foreseeable future, and we might never achieve or maintain profitability. Even if we succeed in developing
and commercializing one or more product candidates, we expect to incur substantial losses for the foreseeable future and might never become profitable. From inception through December 31, 2008 we had losses of $69.8 million. We had net losses
of $35.1 million and $15.1 million for the years ended December 31, 2008 and 2007, respectively, and we anticipate losses for the foreseeable future. Actual losses will depend on a number of considerations, including:



| |  |  | the pace and success of preclinical development and clinical trials for droxidopa, antifolates and other product candidates;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------



| |  |  | our ability to leverage or liquidate our holdings in auction rate securities (ARS);
| | - |  | -----------------------------------------------------------------------------------



| |  |  | possible out-licensing of our product candidates;
| | - |  | -------------------------------------------------



| |  |  | seeking regulatory approval for our various product candidates;
| | - |  | ---------------------------------------------------------------



| |  |  | discussions with regulatory agencies concerning the design of our clinical trials
| | - |  | ---------------------------------------------------------------------------------



| |  |  | our ability to identify and recruit patients into our clinical trials at costs consistent with our current estimates;
| | - |  | ---------------------------------------------------------------------------------------------------------------------



| |  |  | the pace of development of new intellectual property for our existing product candidates;
| | - |  | -----------------------------------------------------------------------------------------



| |  |  | in-licensing and development of additional product candidates;
| | - |  | --------------------------------------------------------------



| |  |  | implementing additional internal systems and infrastructure; and
| | - |  | ----------------------------------------------------------------



| |  |  | hiring additional personnel.
| | - |  | ----------------------------

We
also expect to experience negative cash flow for the foreseeable future as we fund our operating losses and development expenditures. As a result, we will need to generate significant revenue in order to achieve and maintain profitability. We might
not be able to generate revenue or achieve profitability in the future and are unlikely to do so in the near term. Our failure to achieve or maintain profitability could negatively impact the value of our securities.

We are a development-stage company and might not be able to commercialize any product candidates.

We are a development-stage company and have not demonstrated our ability to perform the functions necessary for the successful commercialization of any
product candidates. The successful commercialization of any product candidates will require us to perform a variety of functions, including:



| |  |  | continuing to undertake preclinical development and clinical trials;
| | - |  | --------------------------------------------------------------------



| |  |  | participating in regulatory approval processes;
| | - |  | -----------------------------------------------



| |  |  | formulating and manufacturing products; and
| | - |  | -------------------------------------------



| |  |  | conducting sales, marketing and distribution activities.
| | - |  | --------------------------------------------------------



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Our operations have been limited to organizing and staffing our company, negotiating in-licensing
agreements with our partners, acquiring, developing and securing our proprietary technology, participating in regulatory discussions with the FDA, the EMEA and other regulatory agencies and undertaking preclinical trials and clinical trials of our
product candidates. These operations provide a limited basis for you to assess our ability to commercialize our product candidates and the advisability of investing in our securities.

We may be subjected to unforeseen or unanticipated market conditions that could adversely affect our available working capital and financial position.

We hold positions in investments that consist of certain auction rate securities (ARS). These investments represent interests in collateralized debt
obligations supported by pools of student loans with long-term nominal maturities but for which interest rates are normally reset monthly through a dutch auction process. Consistent with our policy, all ARS investments had at least A credit
ratings at the time of purchase. However, in early 2008, auctions for the resale of such securities ceased to support the liquidity of these securities. We continue to receive interest according to the stated terms of the investments, including
above market interest rates related to the auction failures. However, we cannot be certain that liquidity will be restored to the market in the foreseeable future, in which case we may be unable to sustain our development programs as currently
planned. We may not be able to access cash by selling these securities for which there is insufficient demand without a loss of principal until a future auction for these investments is successful, the secondary market begins to have more regular
and recurring transactions, they are redeemed by their issuer or they mature. The recorded fair value of such investments could potentially be further impaired on a temporary or other-than-temporary basis and we would be required to take additional
write-downs on our investments.

Our potential future earnings may be reduced should we decide to out-license one or more of our drug product candidates.

We may decide to out-license one or more of our drug product candidates, reducing future profits available to us. Should we license our
drug product candidates to another pharmaceuticals company, it would allow the partner to market and sell our compounds in one or more markets around the world. If either the antifolates or droxidopa are licensed to a strategic partner, the profit
available to us may be substantially reduced from what might otherwise be possible should we retain all rights to the products and market and sell them directly.

We might not obtain the necessary U.S. or worldwide regulatory approvals to commercialize any product candidates.

We cannot
assure you that we will receive the approvals necessary to commercialize our product candidates including droxidopa, our antifolates, or any other product candidate either currently in our drug candidate portfolio or which we might acquire or
develop in the future. We will need FDA approval to commercialize our product candidates in the United States and approvals from equivalent regulatory authorities in foreign jurisdictions to commercialize our product candidates in those
jurisdictions. In order to obtain FDA approval of any product candidate, we must submit to the FDA a NDA demonstrating that the product candidate is safe for humans and effective for its intended use. This demonstration requires significant research
and animal tests, which are referred to as preclinical studies, as well as human tests, which are referred to as clinical trials. Satisfaction of the FDAs regulatory requirements typically takes many years, depends upon the type, complexity
and novelty of the product candidate and requires substantial resources for research, development and testing. We cannot predict whether our research and clinical approaches will result in drugs that the FDA considers safe for humans and effective
for indicated uses. The FDA has substantial discretion in the drug approval process and may require us to conduct additional preclinical and clinical testing or to perform post-marketing studies. The approval process might also be delayed by changes
in government regulation, future legislation or administrative action or changes in FDA policy that occur prior to or during our regulatory review. Delays in obtaining regulatory approvals might:



| |  |  | delay commercialization of, and our ability to derive product revenue from, a product candidate;
| | - |  | ------------------------------------------------------------------------------------------------



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| |  |  | impose costly procedures on us; and
| | - |  | -----------------------------------



| |  |  | diminish any competitive advantages that we might otherwise enjoy.
| | - |  | ------------------------------------------------------------------

Even if we comply with all FDA requests, the FDA may ultimately reject one or more of our NDAs. We cannot be sure that we will ever obtain regulatory clearance for any of our product candidates. Failure to obtain FDA
approval of these product candidates, particularly droxidopa or our antifolates, will severely undermine our business and could substantially extend the period before we have a saleable product, leaving us without any source of revenue until another
product candidate can be developed. There is no guarantee that we will ever be able to develop or acquire another product candidate.

In
foreign jurisdictions, we must receive approval from the appropriate regulatory authorities before we can commercialize any drugs. Foreign regulatory approval processes generally include all of the risks associated with the FDA approval procedures
described above. We cannot assure you that we will receive the approvals necessary to commercialize product candidates for sale outside the United States.

Our drug candidates may require extensive reformulation work prior to approval or they may prove unsuitable for further development regardless of reformulation efforts.

We are currently utilizing a formulation of droxidopa in our clinical trials that is obtained from Dainippon Sumitomo Pharma Co., Ltd., or DSP, which uses
a process incompatible with FDA GMP guidelines. During 2008, we collaborated with a contract manufacturing organization and successfully developed a GMP compatible formulation of droxidopa. DSP is also working to finalize an approvable formulation
for the US market. While we believe this activity is progressing at an appropriate pace, final resolution of the manufacturing process and supplier could impact our launch of droxidopa in the US market.

Our development program for CH-1504 was delayed in May of 2006 as a result of data that came to our attention concerning possible bioavailability issues
and animal data suggesting significant variations in blood plasma levels. We have identified and run bioavailability tests on a different formulation of CH-1504 that we believe has improved the drug relative to these issues; however we cannot
determine at this time whether these improvements will be adequate to permit FDA and other regulatory approvals.

Other formulation issues
may arise or prove more significant than anticipated, either with droxidopa, CH-1504 or with other drug candidates in our portfolio.

Our product
candidate CH-1504 has had only limited formal clinical trials.

Our product candidate, CH-1504, is in an early stage of development and
requires extensive clinical testing. In June 2005, we commenced Phase I dose escalation clinical trials of CH-1504 in humans in the United Kingdom at Guys Hospital in London, under the Clinical Trial Authorization issued by the Medicines and
Healthcare Products Regulatory Agency, the United Kingdoms health authority. Following the recent reformulation program, we began additional clinical testing to ascertain equivalency ratios for the reformulated compound as compared to the
compound used during the Phase I trials in the UK. Following this testing we commenced Phase II clinical trials for CH-1504 in rheumatoid arthritis. After the completion of those trials and depending on available funding, we may initiate several
additional Phase II studies in other indications and, as appropriate, Phase III studies in rheumatoid arthritis with or without a partner. Upon completion of the Phase III studies in rheumatoid arthritis, we hope to use data from these studies to
file a NDA in the United States. We currently estimate a global filing of the NDA no sooner than 2011. However, at any point during the process we might decide to focus our efforts on a different lead compound, and we cannot predict with any
certainty the success or timing of our clinical trials, if or when we might submit an NDA for regulatory approval of this product candidate or whether such an NDA will be accepted.



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There has been only very limited testing of our I-3D product candidates.

Our I-3D product candidates are early in their development. None of the candidates have had adequate toxicology testing in animals to permit clinical
testing and there is no clinical evidence of efficacy for any of these candidates, despite limited similarities with compounds currently marketed by others. Animal toxicology trials on our I-3D compounds may not permit further development of these
drugs or we may have to carry out toxicology trials on several compounds before we find one that is appropriate for clinical testing, if at all. Once clinical trials are undertaken, the compound or compounds may not prove adequately safe and
efficacious in humans and may not be approved by the FDA or other regulatory agencies.

Clinical trials are very expensive, time-consuming and difficult
to design and implement.

Human clinical trials are very expensive and difficult to design and implement, in part because they are
subject to rigorous regulatory requirements. The clinical trial process is also time-consuming. For example, because we did not receive orphan drug status from the EMEA for droxidopa as a treatment for Parkinsons disease, our clinical trials
for that indication might have to be more involved and take longer to complete and get reviewed than otherwise would have been the case. Furthermore, failure can occur at any stage of the trials, and we could encounter problems that cause us to
abandon or repeat clinical trials. The commencement and completion of clinical trials might be delayed by several factors, including:



| |  |  | unforeseen safety issues;
| | - |  | -------------------------



| |  |  | clarification of dosing issues;
| | - |  | -------------------------------



| |  |  | lack of effectiveness during clinical trials;
| | - |  | ---------------------------------------------



| |  |  | slower than expected rates of patient recruitment, including the aggregate of approximately 675 patients required to complete the several Phase I, Phase II and
Phase III trials that are or are expected to be ongoing in 2009;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | inability to monitor patients adequately during or after treatment;
| | - |  | -------------------------------------------------------------------



| |  |  | inability or unwillingness of medical investigators to follow our clinical protocols; and
| | - |  | -----------------------------------------------------------------------------------------



| |  |  | unexpected emergence of competitive drugs against which our compounds might compete for clinical trial resources or need to be tested.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------

In addition, we or the FDA or another governing regulatory agency may suspend our clinical trials at any time if it appears that we are exposing
participants to unacceptable health risks or if the regulatory agency finds deficiencies in the conduct of these or our regulatory submissions. Therefore, we cannot predict with any certainty the schedule for our current or any future clinical
trials.

The results of our clinical trials might not support our product candidate claims.

Even if our clinical trials are completed as planned, we cannot be certain that their results will support our product candidate claims. Success in
preclinical testing and early clinical trials does not ensure that later clinical trials will be successful, and we cannot be sure that the results of later clinical trials will replicate the results of prior clinical trials and preclinical testing.
The clinical trial process might fail to demonstrate that our product candidates are safe for humans and effective for indicated uses. This failure would cause us to abandon a product candidate and might delay development of other product
candidates. Any delay in, or termination of, our clinical trials will delay the filing of our NDAs with the FDA and, ultimately, our ability to commercialize our product candidates and generate product revenue.



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We intend to explore additional indications for droxidopa, however these programs may not prove successful.

We have announced our exploration of certain additional indications for droxidopa and we may make similar announcements in the future.
While trials conducted by our partner, DSP, for the Japanese market provide evidence of efficacy for certain indications, other indications may be explored for which we have no existing clinical evidence of efficacy. Such trials are likely to be
very costly. We do not have market approval from the FDA or other regulatory agencies for any of the indications we are exploring and there are no guarantees that additional clinical trials will provide new evidence of efficacy in the targeted
indications or permit us to gain market approval from regulatory agencies.

Physicians and patients might not accept and use our drugs.

Even if the FDA approves any of our product candidates, physicians and patients might not accept and use them. Acceptance and use of our products will
depend upon a number of factors including:



| |  |  | perceptions by members of the healthcare community, including physicians, about the safety and effectiveness of our drug;
| | - |  | -------------------------------------------------------------------------------------------------------------------------



| |  |  | cost-effectiveness of our product relative to competing products;
| | - |  | -----------------------------------------------------------------



| |  |  | understanding by prescribing physicians of the medical conditions we are attempting to address;
| | - |  | -----------------------------------------------------------------------------------------------



| |  |  | availability of reimbursement for our product from government or other healthcare payers; and
| | - |  | ---------------------------------------------------------------------------------------------



| |  |  | effectiveness of marketing and distribution efforts by us and our licensees and distributors, if any.
| | - |  | -----------------------------------------------------------------------------------------------------

Because we expect that sales of our product candidates could, if approved, generate a substantial portion of our product revenue for an extended period,
the failure of such a drug to find market acceptance would harm our business and could require us to seek additional financing or curtail our operations.

Our drug development program depends upon third-party researchers who are outside our control.

We depend upon independent
clinical research organizations, investigators and other collaborators, such as universities and medical institutions, to conduct our preclinical and clinical trials under agreements with us. These collaborators are not our employees and we cannot
control the amount or timing of resources that they devote to our programs. They might not assign as great a priority to our programs or pursue them as diligently as we would if we were undertaking such programs ourselves. If outside collaborators
fail to devote sufficient time and resources to our drug-development programs, or if their performance is substandard, the approval of our FDA applications, if any, and our introduction of new drugs, if any, will be delayed. These collaborators
might also have relationships with other commercial entities, some of which might compete with us. If our collaborators assist our competitors at our expense, our competitive position would be harmed.

Our drug development program also depends upon our partners who are outside our control.

We have licensed certain rights related to droxidopa from DSP and depend upon them for data and support in advancing our clinical program for this
compound. In addition, DSP is currently the sole manufacturer of this compound for our clinical program. Without the timely support of DSP or any other partners, our drug development programs could suffer significant delays, require significantly
higher spending or face cancellation.

We rely exclusively on third parties to formulate and manufacture any product candidates

We have only limited experience in drug formulation and no experience in drug manufacturing and do not intend to establish our own manufacturing
facilities. We lack the resources and expertise to formulate or manufacture our own product candidates. While we have a contract in place with DSP covering droxidopa, we currently have no contract for the commercial scale manufacture of our
antifolates or I-3D compounds. We have



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contracted with one or more manufacturers to manufacture, supply, store and distribute drug supplies for our clinical trials. If any of our current product
candidates or any other product candidates that we may develop or acquire in the future receive FDA approval, we will rely on one or more third-party contractors to manufacture our drugs. Our anticipated future reliance on a limited number of
third-party manufacturers exposes us to the following risks:



| |  |  | We might not be able to identify manufacturers on acceptable terms or at all because the number of potential manufacturers is limited and the FDA must approve any
replacement contractor. This approval would require new testing and compliance inspections. In addition, a new manufacturer would have to be educated in, or develop substantially equivalent processes for, production of our products after receipt of
FDA approval, if any.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Our third-party manufacturers might be unable to formulate and manufacture our drugs in the volume and of the quality required to meet our clinical needs and
commercial needs, if any.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Our contract manufacturers might not perform as agreed or might not remain in the contract manufacturing business for the time required to supply our clinical
trials or to successfully produce, store and distribute our products.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Drug manufacturers are subject to ongoing periodic unannounced inspection by the FDA, the DEA, and corresponding state agencies to ensure strict compliance with
good manufacturing practice and other government regulations and corresponding foreign standards. We do not have control over third-party manufacturers compliance with these regulations and standards.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Each of these risks could delay our clinical trials, the approval, if any, of our product candidates by the FDA or the commercialization of our product
candidates or result in higher costs or deprive us of potential product revenue.

We have no experience selling, marketing or distributing products and
only limited internal capability to do so.

We currently have no sales, marketing or distribution capabilities other than as provided by
our Vice President of Sales and Marketing. We do not anticipate having significant additional resources within the next six months to allocate to the sales and marketing of our proposed products. As a result, our future success depends, in part, on:



| |  |  | our ability to enter into and maintain collaborative relationships for these capabilities, either through out-licensing of our compounds or through contracting
organizations;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the collaborators strategic interest in the products under development; and
| | - |  | ----------------------------------------------------------------------------



| |  |  | such collaborators ability to successfully market and/or sell any such products.
| | - |  | ---------------------------------------------------------------------------------

To the extent that we decide not to, or are unable to, enter into collaborative arrangements with respect to the sales and marketing of our proposed
products or if we decide to add internal resources to complement third party resources, significant development expenditures, management resources and time will be required to establish and develop our own marketing and sales force with technical
expertise.

If we cannot compete successfully for market share against other drug companies, we will not achieve sufficient product revenue and our
business will suffer.

The market for our antifolate product candidates is characterized by intense competition and rapid technological
advances. The initial market for droxidopa, while smaller, has well established generic competition. Other markets for droxidopa, such as fibromyalgia, are emerging with new and heavily marketed offerings. If our antifolates, droxidopa or other
product candidates receive FDA approval, they will compete with a number of existing and future drugs and therapies developed, manufactured and marketed by others. Existing or future competing products might provide greater therapeutic convenience,
efficacy or other benefits for a specific



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indication than our products or might offer comparable performance at a lower cost. If our products fail to capture and maintain market share, we will not
achieve sufficient product revenue and our business will suffer.

We will compete against fully integrated pharmaceutical companies and
smaller companies that are collaborating with larger pharmaceutical companies, academic institutions, government agencies and other public and private research organizations. Many of these competitors have compounds already approved or in
development. In addition, many of these competitors, either alone or together with their collaborative partners, operate larger research and development programs or have substantially greater financial resources than we do, as well as significantly
greater experience in:



| |  |  | developing drugs;
| | - |  | -----------------



| |  |  | undertaking preclinical testing and human clinical trials;
| | - |  | ----------------------------------------------------------



| |  |  | obtaining FDA and other regulatory approvals of drugs;
| | - |  | ------------------------------------------------------



| |  |  | formulating and manufacturing drugs;
| | - |  | ------------------------------------



| |  |  | launching, marketing and selling drugs; and
| | - |  | -------------------------------------------



| |  |  | post-marketing safety surveillance.
| | - |  | -----------------------------------

Our ability
to generate product revenue will be diminished if our drugs sell for inadequate prices or patients are unable to obtain adequate levels of reimbursement.

Our ability to commercialize our drugs, alone or with collaborators, will depend in part on the extent to which reimbursement will be available from:



| |  |  | government and health administration authorities;
| | - |  | -------------------------------------------------



| |  |  | private health maintenance organizations and health insurers; and
| | - |  | -----------------------------------------------------------------



| |  |  | other healthcare payers.
| | - |  | ------------------------

Significant uncertainty exists as to the reimbursement status of newly approved healthcare products. Healthcare payers, including Medicare, are challenging the prices charged for medical products and services. Government and other
healthcare payers increasingly attempt to contain healthcare costs by limiting both coverage and the level of reimbursement for drugs. Even if a product candidate is approved by the FDA, insurance coverage might not be available and reimbursement
levels might be inadequate to cover our drug. If government and other healthcare payers do not provide adequate coverage and reimbursement levels for our product, once approved, market acceptance and our revenue could be reduced.

Specifically, not all physicians recognize a separate indication for symptomatic neurogenic orthostatic hypotension and we cannot provide assurances that
reimbursement will be approved by the relevant decision makers even if droxidopa receives market approval from the FDA or other regulatory authorities.

Developments by competitors might render our products or technologies obsolete or non-competitive.

Companies that currently
sell both generic and proprietary compounds for the treatment of rheumatoid arthritis include, but are not limited to, Abbott Laboratories, Amgen, Sanofi-Aventis, Barr Laboratories, Boehringer Ingelheim Pharma, Hoffmann-La Roche, Johnson &
Johnson, Bristol-Myers Squibb and Mylan Laboratories. Companies that currently sell compounds used for the treatment of orthostatic hypotension include Shire, Mylan Pharmaceuticals, Eon Labs, Impax Laboratories and King Pharmaceuticals. Alternative
technologies are being developed to treat rheumatoid arthritis by numerous companies including Pfizer, Rigel and Celltech, which are in advanced clinical trials. In addition, companies pursuing different but related fields represent substantial
competition. Many of these organizations competing with us have substantially greater capital resources, larger research and development staffs and facilities, longer drug development history in



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obtaining regulatory approvals and greater manufacturing and marketing capabilities than we do. These organizations also compete with us to attract qualified
personnel and parties for acquisitions, joint ventures or other collaborations.

Our success, competitive position and future revenue will depend in
part on our ability to obtain and maintain patent protection for our products, methods, processes and other technologies, to preserve our trade secrets, to prevent third parties from infringing on our proprietary rights and to operate without
infringing the proprietary rights of third parties.

We do not know whether any of our pending patent applications or those patent
applications that we may file or license in the future will result in the issuance of any patents. Moreover, we cannot predict the degree of patent protection that will be afforded by those patent applications that do result in issuance. Although we
generally seek the broadest patent protection available for our proprietary compounds, we may not be able to obtain patent protection for the actual composition of any particular compound and may be limited to protecting a new method of use for the
compound or otherwise restricted in our ability to prevent others from exploiting the compound. If our patent protection for any particular compound is limited to a particular method of use or indication such that, if a third party were to obtain
approval of the compound for use in another indication, we could be subject to competition arising from off-label use.

Moreover, our
issued patents and those that may issue in the future, or those licensed to us, may be challenged, invalidated, rendered unenforceable or circumvented, any of which could limit our ability to stop competitors from marketing related products. In
addition, the rights granted under any issued patents may not provide us with competitive advantages against competitors with similar compounds or technologies. Furthermore, our competitors may independently develop similar technologies in a manner
that does not infringe our patents or other intellectual property.

If a third party legally challenges our patents or other intellectual
property rights that we own or license, we could lose certain of these rights. For example, third parties may challenge the validity of our U.S. or foreign patents through reexaminations, oppositions or other legal proceedings. If successful, a
challenge to our patents or other intellectual property rights could deprive us of competitive advantages and permit our competitors to use our technology to develop similar products.

In addition, we do not anticipate having patent protection on droxidopa when and if it receives market approval by the FDA for NOH under the brand name
Northera. While the orphan drug designation for this compound by the FDA will provide seven years of market exclusivity, we will not be able to exclude other companies from manufacturing and/or selling this compound beyond that timeframe.

Claims by third parties that we infringe their proprietary rights may result in liability for damages or prevent or delay our developmental and
commercialization efforts.

If a third party were to file a patent infringement suit against us, we could be forced to stop or delay
research, development, manufacturing or sales of any infringing product in the country or countries covered by the patent infringed, unless we can obtain a license from the patent holder. Any necessary license may not be available on acceptable
terms or at all, particularly if the third party is developing or marketing a product competitive with the infringing product. Even if we are able to obtain a license, the rights may be nonexclusive, which would give our competitors access to the
same intellectual property. We also may be required to pay substantial damages to the patent holder in the event of an infringement. If we have supplied infringing products to third parties for marketing or have licensed third parties to
manufacture, use or market infringing products, we may be obligated to indemnify these third parties for any damages they may be required to pay to the patent holder and for any losses they may sustain themselves as a result.



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We may initiate patent litigation against third parties to protect or enforce our patent rights. Failure to protect
our patents and other proprietary rights may materially harm our business, financial condition and results of operations.

Legal or
administrative proceedings may be necessary to defend against claims of infringement or to enforce our intellectual property rights. If we become involved in any such proceeding, irrespective of the outcome, we may incur substantial costs, and the
efforts of our technical and management personnel may be diverted, which could materially harm our business. Furthermore, because of the substantial amount of discovery required in connection with intellectual property litigation, there is a risk
that disclosure of some of our confidential information could be compelled and the information compromised. In addition, during the course of this kind of litigation, there could be public announcements of the results of hearings, motions or other
interim proceedings or developments that, if perceived as negative by securities analysts or investors, could have a substantial adverse effect on the trading price of our common stock.

Existing patents and proprietary rights could harm our competitive position.

Other entities may have
or obtain patents or proprietary rights that could limit our ability to manufacture, use, sell, offer for sale or import products or impair our competitive position. In addition, to the extent that a third party develops new technology that covers
our products, we may be required to obtain licenses to that technology, which licenses might not be available or may not be available on commercially reasonable terms, if at all. Our failure to obtain a license to any technology that we require may
materially harm our business, financial condition and results of operations.

Changes in either patent laws or in interpretations of patent laws in the
United States and other countries may diminish the value of our intellectual property or narrow the scope of our patent protection.

The
laws of foreign countries may not protect our rights to the same extent as the laws of the United States. Therefore, enforceability or scope of our patents in the United States or in foreign countries cannot be predicted with certainty, and, as a
result, any patents that we own or license may not provide sufficient protection against competitors.

Some jurisdictions have laws that
permit the government to force a patentee to grant a license to a third party for commercialization of a patented product if the government concludes that the product is not sufficiently developed or not meeting the health needs of the population.
Such compulsory licensing laws are very rarely invoked outside of South America and Africa. In addition, a number of countries limit the enforceability of patents against government agencies or government contractors. In these countries, the patent
owner may be limited to monetary relief and may be unable to enjoin infringement, which could materially diminish the value of the patent. Such compulsory licenses could be extended to include some of our product candidates, which may limit our
potential revenue opportunities.

Because of the extensive time required for development, testing and regulatory review of a new drug, it
is possible that any related patent may expire before any of our product candidates can be commercialized or remain in force for only a short period following commercialization. In either case, this would reduce any advantages of the patent.

If we are unable to satisfy our obligations under current and future license agreements, we could lose license rights which would adversely affect our
business.

We are a party to a license agreement with M. Gopal Nair under which we license patent rights for our product candidate
CH-1504 and other antifolates. Similarly, we license patent and/or certain other rights from DSP for droxidopa. We may enter into additional licenses in the future. Our existing licenses impose, and we expect future licenses will impose, various
milestone payments, royalty payments and other obligations on us. If we fail to comply with our obligations in our intellectual property licenses with third parties, we could lose



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license rights that are important to our business. If a licensor challenges our license position, our competitive position and business prospects could be
harmed.

Our license agreement with Dr. Nair reserves rights to the licensor in India. Therefore, we will not commercialize our
antifolates in India. Our license agreement with DSP reserves rights to the licensor in Japan, Korea, China and Taiwan which preclude our commercialization of droxidopa in those markets.

If we are unable to enforce trade secret protection and confidentiality agreements with our employees, our competitive position might be harmed.

Our success also depends upon the skills, knowledge and experience of our scientific and technical personnel, our consultants and advisors, as well as our
licensors and contractors. To help protect our proprietary know-how and our inventions for which patents are unobtainable or difficult to obtain, we rely on trade secret protection and confidentiality agreements. To this end, it is our policy to
require all of our employees, consultants, advisors and contractors to enter into agreements that prohibit the disclosure of confidential information and, where applicable, require disclosure and assignment to us of the ideas, developments,
discoveries and inventions important to our business. These agreements might not provide adequate protection for our trade secrets, know-how or other proprietary information in the event of any unauthorized use or disclosure or the lawful
development by others of such information. If any of our trade secrets, know-how or other proprietary information is disclosed, the value of our trade secrets, know-how and other proprietary rights would be significantly impaired and our business
and competitive position would suffer.

If we infringe the rights of third parties we could be prevented from selling products, forced to pay damages
and defend against litigation.

If our products, methods, processes and other technologies infringe the proprietary rights of other
parties, we could incur substantial costs and we might have to:



| |  |  | obtain licenses, which might not be available on commercially reasonable terms, if at all;
| | - |  | ------------------------------------------------------------------------------------------



| |  |  | abandon an infringing drug candidate;
| | - |  | -------------------------------------



| |  |  | redesign our products or processes to avoid infringement;
| | - |  | ---------------------------------------------------------



| |  |  | stop using the subject matter claimed in the patents held by others;
| | - |  | --------------------------------------------------------------------



| |  |  | pay damages; or
| | - |  | ---------------



| |  |  | defend litigation or administrative proceedings, which might be costly whether we win or lose, and which could result in a substantial diversion of valuable
management resources.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

We might not successfully manage our growth.

We are a small, development stage company. Our success will depend upon the expansion of our operations and the effective management of our growth, which
will place a significant strain on our management and on our administrative, operational and financial resources. We currently have 17 employees. We may also have to augment our operational, financial and management systems and hire and train even
more qualified personnel. If we are unable to manage our growth effectively, our business would be harmed.

We might be exposed to liability claims
associated with the use of hazardous materials and chemicals.

Our research and development activities might involve the controlled use
of hazardous materials and chemicals. Although we believe that our safety procedures, and those of our partners, for using, storing, handling and disposing of these materials comply with federal, state, local and, where applicable, foreign laws and
regulations, we cannot completely eliminate the risk of accidental injury or contamination from these materials. In the event of such an accident, we could be held liable for any resulting damages and any liability could



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materially adversely affect our business, financial condition and results of operations. In addition, the laws and regulations governing the use,
manufacture, storage, handling and disposal of hazardous or radioactive materials and waste products might require us to incur substantial compliance costs that could materially adversely affect our business, financial condition and results of
operations.

We rely on key executive officers and scientific and medical advisors, and their knowledge of our business and technical expertise would be
difficult to replace.

As a small, development stage company, we are highly dependent on our executive officers, including particularly
our Chief Executive Officer, Simon Pedder, Ph.D., and our principal scientific, regulatory and medical advisors. Dr. Pedder is the only executive officer whose employment with us is governed by an employment agreement, and the term of
employment under that agreement expires in May 2009. We do not have key person life insurance policies for any of our officers. The loss of the technical knowledge and management and industry expertise of any of our key personnel could
result in delays in product development, loss of any future customers and sales and diversion of management resources, which could adversely affect our operating results.

If we are unable to hire additional qualified personnel, our ability to grow our business will be harmed.

As a small, development stage company, we will need to hire additional qualified personnel with expertise in preclinical testing, clinical research and testing, government regulation, formulation and manufacturing and sales and marketing.
We compete for qualified individuals with numerous pharmaceutical and biopharmaceutical companies, universities and other research institutions. Competition for such individuals is intense, and we cannot be certain that our search for such personnel
will be successful. Attracting and retaining qualified personnel is critical to our success.

We might incur substantial liabilities and might be
required to limit commercialization of our products in response to product liability lawsuits.

The testing and marketing of medical
products entail an inherent risk of product liability. If we cannot successfully defend ourselves against product liability claims, we might incur substantial liabilities or be required to limit commercialization of our products. Our inability to
obtain sufficient product liability insurance at an acceptable cost to protect against potential product liability claims could prevent or inhibit the commercialization of our products. Although we carry clinical trial insurance, we might not be
able to renew such insurance at a reasonable cost, if at all, or our intended collaborators may be unable to obtain such insurance at a reasonable cost, if at all. Even if our agreements with any future collaborators entitle us to indemnification
against losses, that indemnification might not be available or adequate should any claim arise.

The trading volume of our common stock is limited and
our investors may encounter difficulties selling significant quantities of our stock without adversely impacting the price at which they can sell.

Since listing with the NASDAQ Stock Market in May 2006, the trading volume for our stock has varied significantly from day to day and often the number of shares traded has been low. No assurance can be given that a
more liquid trading market will develop.

The prices at which are shares of our common stock are traded will likely be volatile.

You should expect the prices at which our common stock is traded to be highly volatile. Since the commencement of NASDAQ trading in May 2006, the price
has varied from a low of $1.09 to a high of $8.41. The expected volatile price of our stock will make it difficult to predict the value of your investment, to sell your shares at a profit at any given time, or to plan purchases and sales in advance.
A variety of other factors might also affect the market price of our common stock. These include, but are not limited to:



| |  |  | publicity regarding actual or potential clinical results relating to products under development by our competitors or us;
| | - |  | -------------------------------------------------------------------------------------------------------------------------



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| |  |  | delays or failures in initiating, completing or analyzing preclinical or clinical trials or the unsatisfactory design or results of these trials;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | achievement or rejection of regulatory approvals by our competitors or us;
| | - |  | --------------------------------------------------------------------------



| |  |  | announcements of technological innovations or new commercial products by our competitors or us;
| | - |  | -----------------------------------------------------------------------------------------------



| |  |  | developments concerning proprietary rights, including patents;
| | - |  | --------------------------------------------------------------



| |  |  | developments concerning our collaborations;
| | - |  | -------------------------------------------



| |  |  | regulatory developments in the United States and foreign countries;
| | - |  | -------------------------------------------------------------------



| |  |  | economic or other crises and other external factors;
| | - |  | ----------------------------------------------------



| |  |  | period-to-period fluctuations in our results of operations;
| | - |  | -----------------------------------------------------------



| |  |  | changes in financial estimates by securities analysts; and
| | - |  | ----------------------------------------------------------



| |  |  | sales of our common stock.
| | - |  | --------------------------

We will
not be able to control many of these factors, and we believe that period-to-period comparisons of our financial results will not necessarily be indicative of our future performance.

In addition, the stock market in general, and the market for biotechnology companies in particular, has experienced extreme price and volume fluctuations
that might have been unrelated or disproportionate to the operating performance of individual companies. These broad market and industry factors might seriously harm the market price of our common stock, regardless of our operating performance.

We have never paid dividends and do not intend to pay cash dividends.

We currently anticipate that no cash dividends will be paid on our common stock in the foreseeable future. While our dividend policy will be based on the operating results and capital needs of the business, it is
anticipated that all earnings, if any, will be retained to finance our future operations.

ITEM 1B. UNRESOLVED STAFF
COMMENTS

None.

ITEM 2. PROPERTIES

We currently lease 9,956 square feet of office space in Charlotte, North
Carolina. This lease requires us to make monthly payments of $19,041. The lease expires on October 15, 2013 and calls for annual rent increases of 3%. In addition, the lease provides an option to rent an additional 3,000 square feet of
adjacent space. The option remains in effect until November 2009 at a cost of $1,750 per month unless terminated sooner at our discretion. A security deposit equal to four months rent, or $76,163, was paid upon signing the lease. We
believe that these facilities, including the option space described above, are adequate to meet our needs through 2011.

ITEM 3. LEGAL PROCEEDINGS

We are not subject to any pending legal proceeding, nor are we
aware of any threatened claims against us.

ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

No matters were submitted to a vote of our security holders during the fourth quarter of the year ended December 31, 2008.



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PART II

ITEM 5. MARKET FOR THE REGISTRANTS COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES

Our common stock has been traded on the National Association of Securities Dealers Automatic Quotation System (NASDAQ) under the symbol
CHTP since May 2, 2006 and traded on the Over-the-Counter Bulletin Board under the symbol CHTP.OB from July 29, 2005 through May 1, 2006 and under the symbol IVRC.OB from August 18, 2004
through July 28, 2005. The following table sets forth the high and low prices of our common stock, as reported per the appropriate market. These quotations reflect inter-dealer prices, without retail mark-up, markdown, or commission and may not
represent actual transactions. Trading on our common stock has been sporadic, exemplified by low trading volume, with 213 of 673 trading days between our listing on NASDAQ and the end of 2008 having fewer than 10,000 shares traded.



|                                    |  |      |      |     |   |     
|----------------------------------- |  | ---- | ---- | --- | - | ----
|                                    |  | High |      | Low
|Fiscal year ended December 31, 2007 |  |      |      |     |   |     
|First Quarter                       |  | $    | 6.70 |     | $ | 3.56
|Second Quarter                      |  | $    | 7.02 |     | $ | 5.05
|Third Quarter                       |  | $    | 8.10 |     | $ | 5.09
|Fourth Quarter                      |  | $    | 7.80 |     | $ | 5.80
|                                    |  |     
|Fiscal year ended December 31, 2008 |  |      |      |     |   |     
|First Quarter                       |  | $    | 8.41 |     | $ | 4.77
|Second Quarter                      |  | $    | 6.00 |     | $ | 4.45
|Third Quarter                       |  | $    | 6.90 |     | $ | 2.67
|Fourth Quarter                      |  | $    | 3.42 |     | $ | 1.09
|                                    |  |      |      |     |   |     

As of March 2, 2009, the last sale price of our common stock on NASDAQ was $1.49 per share. As of
March 2, 2009, there were approximately 712 stockholders of record.

We have neither paid nor declared dividends on our common stock since
our inception and do not plan to pay dividends in the foreseeable future. Any earnings that we may realize will be reinvested to finance our growth.

The market prices for securities of biotechnology and pharmaceutical companies, including ours, have historically been highly volatile, and the market has from time to time experienced significant price and volume
fluctuations that are unrelated to the operating performance of particular companies. Factors, such as fluctuations in our operating results, announcements of technological innovations or new therapeutic products by us or others, clinical trial
results, developments concerning agreements with collaborators, governmental regulation, developments in patent or other proprietary rights, public concern as to the safety of drugs developed by us or others, future sales of substantial amounts of
common stock by existing stockholders and general market conditions, can have an adverse effect on the market price of our common stock.



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ITEM  6. SELECTED FINANCIAL DATA.

The following table sets forth financial data with respect to us as of and for the five years ended December 31, 2008 and the period from
April 3, 2002 (inception) through December 31, 2008. The selected financial data below should be read in conjunction with the audited financial statements and related notes included elsewhere in this Annual Report on Form 10-K and
Managements Discussion and Analysis of Financial Condition and Results of Operations included in Item 7.



|                                                            |  |                                                 |            |   |                                                        |   |            |      |  |   |            |   |  |      |            |   |  |   |           |   |  |   |         |  
|----------------------------------------------------------- |  | ----------------------------------------------- | ---------- | - | ------------------------------------------------------ | - | ---------- | ---- |  | - | ---------- | - |  | ---- | ---------- | - |  | - | --------- | - |  | - | ------- | -
|                                                            |  | Years ended December 31,                        |            |   | Period fromApril 3, 2002(Inception) toDecember 31,2008 |  
|                                                            |  | 2008                                            |            |   | 2007                                                   |   |            | 2006 |  |   | 2005       |   |  | 2004 |            |  
|                                                            |  | (In thousands, except share and per share data) |            |   |                                                        |  
|Statement of Operations Data:                               |  |                                                 |            |   |                                                        |   |            |      |  |   |            |   |  |      |            |   |  |   |           |   |  |   |         |  
|Operating expenses:                                         |  |                                                 |            |   |                                                        |   |            |      |  |   |            |   |  |      |            |   |  |   |           |   |  |   |         |  
|Research and development                                    |  | $                                               | 27,109     |   |                                                        | $ | 12,336     |      |  | $ | 6,864      |   |  | $    | 5,516      |   |  | $ | 1,809     |   |  | $ | 53,634  |  
|Sales and marketing                                         |  |                                                 | 1,561      |   |                                                        |   | 1,294      |      |  |   | 642        |   |  |      | 524        |   |  |   | 168       |   |  |   | 4,191   |  
|General and administrative                                  |  |                                                 | 3,727      |   |                                                        |   | 2,875      |      |  |   | 2,028      |   |  |      | 2,076      |   |  |   | 1,012     |   |  |   | 11,717  |  
|                                                            |  |                                                 |            |   |                                                        |   |            |      |  |   |            |   |  |      |            |   |  |   |           |   |  |   |         |  
|Total operating expenses                                    |  |                                                 | 32,397     |   |                                                        |   | 16,505     |      |  |   | 9,534      |   |  |      | 8,116      |   |  |   | 2,989     |   |  |   | 69,542  |  
|                                                            |  |                                                 |            |   |                                                        |   |            |      |  |   |            |   |  |      |            |   |  |   |           |   |  |   |         |  
|Operating loss                                              |  |                                                 | (32,397    | ) |                                                        |   | (16,505    | )    |  |   | (9,534     | ) |  |      | (8,116     | ) |  |   | (2,989    | ) |  |   | (69,542 | )
|Interest income and (expense), net                          |  |                                                 | 1,701      |   |                                                        |   | 1,424      |      |  |   | 863        |   |  |      | 200        |   |  |   | (28       | ) |  |   | 4,161   |  
|Other expense                                               |  |                                                 | (4,390     | ) |                                                        |   |           |      |  |   |           |   |  |      |           |   |  |   |          |   |  |   | (4,390  | )
|                                                            |  |                                                 |            |   |                                                        |   |            |      |  |   |            |   |  |      |            |   |  |   |           |   |  |   |         |  
|Net loss                                                    |  | $                                               | (35,086    | ) |                                                        | $ | (15,081    | )    |  | $ | (8,671     | ) |  | $    | (7,916     | ) |  | $ | (3,017    | ) |  | $ | (69,771 | )
|                                                            |  |                                                 |            |   |                                                        |   |            |      |  |   |            |   |  |      |            |   |  |   |           |   |  |   |         |  
|Basic and diluted net loss per share                        |  | $                                               | (1.17      | ) |                                                        | $ | (0.66      | )    |  | $ | (0.46      | ) |  | $    | (0.64      | ) |  | $ | (0.47     | ) |  |   |         |  
|                                                            |  |                                                 |            |   |                                                        |   |            |      |  |   |            |   |  |      |            |   |  |   |           |   |  |   |         |  
|Shares used to compute basic and diluted net loss per share |  |                                                 | 30,027,031 |   |                                                        |   | 22,936,780 |      |  |   | 18,780,638 |   |  |      | 12,321,061 |   |  |   | 6,431,451 |   |  |   |         |  
|                                                            |  |                                                 |            |   |                                                        |   |            |      |  |   |            |   |  |      |            |   |  |   |           |   |  |   |         |  



|                                                 |  |                    |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |        |  
|------------------------------------------------ |  | ------------------ | ------- | - | ---- | - | ------- | ---- |  | - | ------- | - |  | ---- | ------- | - |  | - | ------ | -
|                                                 |  | As of December 31, |        
|                                                 |  | 2008               |         |   | 2007 |   |         | 2006 |  |   | 2005    |   |  | 2004 |        
|                                                 |  | (in thousands)     |        
|Balance Sheet Data:                              |  |                    |         |   |      |   |         |      |  |   |         |   |  |      |         |   |  |   |        |  
|Cash and cash equivalents                        |  | $                  | 21,533  |   |      | $ | 34,076  |      |  | $ | 3,111   |   |  | $    | 3,173   |   |  | $ | 10,977 |  
|Short-term investments, net                      |  |                    | 10,306  |   |      |   | 28,638  |      |  |   | 12,786  |   |  |      |        |   |  |   |       |  
|Working capital                                  |  |                    | 20,260  |   |      |   | 57,910  |      |  |   | 14,080  |   |  |      | 2,328   |   |  |   | 10,476 |  
|Long-term investments, net                       |  |                    | 11,329  |   |      |   |        |      |  |   |        |   |  |      |        |   |  |   |       |  
|Total assets                                     |  |                    | 44,130  |   |      |   | 63,163  |      |  |   | 16,171  |   |  |      | 3,427   |   |  |   | 11,141 |  
|Long-term line of credit payable                 |  |                    | 7,277   |   |      |   |        |      |  |   |        |   |  |      |        |   |  |   |       |  
|Deficit accumulated during the development stage |  |                    | (69,771 | ) |      |   | (34,685 | )    |  |   | (19,604 | ) |  |      | (10,932 | ) |  |   | (3,017 | )
|Total stockholders equity                       |  |                    | 24,548  |   |      |   | 57,967  |      |  |   | 14,137  |   |  |      | 2,384   |   |  |   | 10,541 |  



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ITEM 7. MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF
OPERATIONS

The following discussion of our financial condition and results of operations should be read in conjunction with the
financial statements and the notes to those statements included elsewhere in this Annual Report on Form 10-K. This discussion contains predictions, estimates and other forward-looking statements that involve a number of risks and uncertainties,
including those discussed under Risk Factors and elsewhere in this Annual Report on Form 10-K. These risks could cause our actual results to differ materially from those anticipated in these forward-looking statements.

Overview

We are a development stage pharmaceutical
company that seeks to acquire, develop and commercialize innovative products for the treatment of a variety of human diseases. Our strategy is to develop technologies that address important unmet medical needs or offer improved, cost-effective
alternatives to current methods of treatment. Specifically, we are developing a novel therapeutic agent for the treatment of neurogenic orthostatic hypotension and related conditions and diseases along with our development of prescription products
for multiple autoimmune disorders including rheumatoid arthritis, psoriasis, inflammatory bowel disease and cancer.

We are currently
focusing the majority of our drug development resources on two clinical stage development projects: droxidopa for symptomatic neurogenic hypotension and other potential indications; and our portfolio of non-metabolized antifolate compounds for the
treatment of rheumatoid arthritis. Droxidopa, our most advanced investigational product candidate, is an orally active synthetic precursor of norepinephrine. It is being developed for the treatment of neurogenic orthostatic hypotension (NOH) and is
currently approved and marketed in Japan for the treatment of symptomatic orthostatic hypotension, freezing of gait in Parkinsons Disease and intradialytic hypotension. During 2007, the FDA granted orphan drug status to droxidopa for the
treatment of NOH and the European Commission granted orphan medicinal product designation for the treatment of patients with Pure Autonomic Failure (PAF) and patients with Multiple Systems Atrophy (MSA). It is currently being studied in double-blind
pivotal Phase III trials under a Special Protocol Assessment, or SPA, with the FDA, designed to compare droxidopa to placebo at multiple sites in North America and Europe. In addition, a double-blind, placebo controlled Phase II clinical study for
the treatment of intradialytic hypotension was recently completed. In addition to droxidopa, we are currently developing a portfolio of molecules for the treatment of various autoimmune/inflammatory diseases. The most advanced platform is a
portfolio of metabolically inert antifolate molecules engineered to have potent anti-inflammatory and anti-tumor activity to treat a range of immunological disorders, including two clinical stage product candidates designated as CH-1504 and CH-4051.
CH-1504 is currently being investigated for the treatment of rheumatoid arthritis in a Phase II head-to-head clinical trial to compare its efficacy and tolerability against methotrexate, currently the leading antifolate treatment and standard of
care for a broad range of abnormal cell proliferation diseases. CH-4051 is currently being investigated in a Phase I study designed to determine the maximum tolerated dose based on results of single-ascending and multiple-ascending evaluations.
Complementing our antifolate program is a second platform consisting of a portfolio of therapeutics targeting immune-mediated inflammatory disorders and transplantation.

Since inception we have focused primarily on organizing and staffing our company, negotiating in-licensing agreements with our partners, acquiring, developing and securing our proprietary technology, participating in
regulatory discussions with the FDA, the EMEA and other regulatory agencies and undertaking preclinical trials and clinical trials of our product candidates. We are a development stage company and have generated no revenue since inception. We do not
anticipate generating any product revenue until and unless we successfully obtain approval from the FDA or equivalent foreign regulatory bodies to begin selling our pharmaceutical candidates. However, developing pharmaceutical products is a lengthy
and expensive process. Even if we do not encounter unforeseen safety issues or timing or other delays during the course of developing our currently licensed product candidates, we would not anticipate receiving regulatory approval to market any such
products until, at the earliest, the second half of 2010. Currently, development expenses are being funded with proceeds



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from equity financings completed in December 2004, February 2006, March 2007 and November 2007. To the extent we move our products into more
extensive clinical trials, our need to finance research and development costs will continue to increase. Accordingly, our success depends not only on the safety and efficacy of our product candidates, but also on our ability to finance the
development of the products.

Revenue and Cost of Revenue

We have not generated any revenue from licensing, milestones or product sales through December 31, 2008. We do not expect to generate product revenue within the next 12 to 18 months but may decide to outlicense
one or more of our drug product candidates during that timeframe. If successful, we would anticipate revenue to be recorded from such a transaction however, we might never be able to generate revenue. None of our existing product candidates are
expected to be commercially available until, at the earliest, the second half of 2010, if at all.

Research and Development

Research and development expenses consist primarily of costs associated with determining feasibility, licensing and preclinical and clinical testing of
our licensed pharmaceutical candidates, including salaries and related personnel costs, fees paid to consultants and outside service providers for drug manufacture and development, certain legal expenses and other expenses. All of our major research
and development projects subject us to drug development and regulatory risks, including specifically risks of delays and cost over-runs that could be material to our financial condition and results of operations. For certain programs, we might rely
on collaborative partners or our ability to enter into collaborations on favorable terms in order to advance candidates and pay a portion of the research and development expenses. See Item 1A. Risk Factors. We expense our research and
development costs as they are incurred. Research and development expenses, related to our three major research and development projects, for the years ended December 31, 2008, 2007 and 2006 were approximately $27.1 million, $12.3 million and
$6.9 million, respectively, and are detailed as follows:



|               |  |                          |        |      |   |        |  |   |      
|-------------- |  | ------------------------ | ------ | ---- | - | ------ |  | - | -----
|               |  | Years ended December 31,
|(in thousands) |  | 2008                     |        | 2007 |   | 2006  
|Antifolates    |  | $                        | 8,900  |      | $ | 4,500  |  | $ | 3,100
|Droxidopa      |  |                          | 18,200 |      |   | 7,000  |  |   | 2,100
|I-3D           |  |                          |       |      |   | 800    |  |   | 1,700
|               |  |                          |        |      |   |        |  |   |      
|               |  | $                        | 27,100 |      | $ | 12,300 |  | $ | 6,900
|               |  |                          |        |      |   |        |  |   |      

Sales and Marketing

Selling and marketing expenses consist primarily of salaries and related expenses that support our business development activity, promotional expenses, expenses related to the branding of our pharmaceutical compounds
and certain legal expenses.

General and Administrative

General and administrative expenses focus on the support of administrative activities and consist primarily of salaries and related expenses for executive, finance and other administrative personnel, recruitment
expenses for such personnel, consulting and professional fees and other corporate expenses, including general legal activities, certain taxes and other government fees and facilities-related expenses.

Corporate History

On February 11, 2005,
we completed a merger with Ivory Capital Corporation, a publicly traded Colorado corporation, in which a wholly owned subsidiary of Ivory Capital was merged with and into Chelsea, and Chelsea became a wholly owned subsidiary of Ivory Capital. The
merger resulted in a change of control of Ivory



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Capital, with the former stockholders of Chelsea owning approximately 96.75% assuming the conversion of all outstanding options and warrants. In addition,
the terms of the merger provided that the sole officer and director of Ivory Capital would be replaced by the officers and directors of Chelsea. The transaction was accounted for as a reverse acquisition with Chelsea as the acquiring party and Ivory
Capital as the acquired party, in substance, a reorganization of Chelsea. Accordingly, when we refer to our business and financial information relating to periods prior to the merger, we are referring to the business and financial information of
Chelsea unless the context indicates otherwise. On July 28, 2005, Ivory Capital Corporation merged with Chelsea Therapeutics International, Ltd., with Chelsea Therapeutics International, Ltd. as the surviving corporation. As a result, Chelsea
Therapeutics International, Ltd. is the public reporting company and is the 100% owner of Chelsea Therapeutics, Inc., its operating subsidiary.

When we refer to business and financial information for periods between January 1, 2005 and July 28, 2005, we are referring to the business and financial information of Ivory Capital Corporation. Except as noted, all share numbers
included herein reflect the conversion of every nine shares of Ivory Capital Corporation common stock for one share of Chelsea Therapeutics International, Ltd. common stock that occurred in connection with our Delaware reincorporation on
July 28, 2005.

Results of Operations

The tables below set forth, for the periods indicated, certain items in our consolidated statements of operations and other pertinent financial and operating data.

Comparison of Years ended December 31, 2008 and 2007



|                                   |  |                                   |        |                                   |   |           |  |         |        |  |     |  
|---------------------------------- |  | --------------------------------- | ------ | --------------------------------- | - | --------- |  | ------- | ------ |  | --- | -
|(in thousands, except percentages) |  | For theYear endedDecember 31,2008 |        | For theYear endedDecember 31,2007 |   | $Increase |  | %Change |       
|Research and development expense   |  | $                                 | 27,109 |                                   | $ | 12,336    |  | $       | 14,773 |  | 120 | %
|Sales and marketing expense        |  |                                   | 1,561  |                                   |   | 1,294     |  |         | 267    |  | 21  | %
|General and administrative expense |  |                                   | 3,727  |                                   |   | 2,875     |  |         | 852    |  | 30  | %
|Interest income                    |  |                                   | 1,707  |                                   |   | 1,424     |  |         | 283    |  | 20  | %
|Other expense                      |  |                                   | 4,390  |                                   |   |          |  |         | 4,390  |  | 100 | %

Research and development expensesincreased in 2008 primarily related to the advancement of
our drug candidates into more extensive clinical testing programs and compensation costs related to the addition of new personnel during the year. As a percentage of operating expenses, research and development costs increased to 84% for 2008 from
75% for 2007. During 2008, we continued our manufacturing, preclinical, Phase I and Phase II activities for our portfolio of antifolates and our manufacturing, formulation, preclinical, Phase II and Phase III activities for droxidopa. Also
contributing to the increase in research and development costs were a $0.7 million increase in compensation and related expenses, a $0.1 million increase in travel and other employee related costs and a $0.3 million increase in licensing costs
related to the achievement of certain milestones. These increases were offset by a decrease of $0.1 million in general contractor and outside services expense.

Droxidopa.From inception through December 31, 2008, we had spent approximately $27.3 million in research and development
expenses on droxidopa. Assuming we do not enter into an out-license, development or other collaborative agreement with respect to this compound, we estimate that subsequent to that date we will need to incur approximately $19.6 million more,
primarily to complete our Phase III clinical trials and submit an NDA to the FDA, to complete development of droxidopa. Assuming its approval for marketing, we currently estimate launch of this product and initial sales or royalty revenue from it no
sooner than the second half of 2010. In addition to the spending requirements above and assuming we have sufficient resources, we plan to spend up to approximately $7.2 million in 2009 for clinical proof of concept studies in other indications, our
once-daily formulation and other droxidopa related programs.



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Antifolates.From inception through December 31, 2008, we had spent
approximately $23.8 million in research and development expenses on our portfolio of antifolates. We currently intend to seek a partner to assist us in the development of our antifolates after the completion of Phase II proof-of-concept studies for
CH-1504 in rheumatoid arthritis late in the first quarter of 2009 and the completion of our Phase 1 dosing evaluation in CH-4051. We estimate that we will spend approximately $1.7 million more for the trials related to proof-of-concept and the
development of other antifolate compounds in 2009. Assuming an approval for marketing, we currently estimate launch of this product and initial royalty revenue from it no sooner than 2012.

I-3D Portfolio.From inception through December 31, 2008, we had spent approximately $2.5 million in research and development
expenses on the I-3D portfolio of compounds. We have conducted compound discovery work on the portfolio to try and indentify one or more lead compounds. All of the work completed to date was performed before 2008 and we do not expect to incur
significant additional expenses for these compounds until we select a partner or obtain additional financing.

Sales and marketing
expenses. We had no formalized selling activities for the year ended December 31, 2008. The increase is primarily related to a $0.2 million increase in professional legal fees related to further securing our intellectual property and a $0.2
million increase in compensation and related expenses.

General and administrative expenses. The $0.8 million increase in general
and administrative expenses consists of a $0.1 million increase in compensation and related expenses; a $0.3 million increase in non-cash stock-based compensation based on grants made in February 2008, the fair values of which reflect our increased
stock price and volatility; a $0.1 million increase in rent and facilities costs related to our new corporate headquarters; and a $0.1 million increase in franchise taxes due to our 2007 issuances of stock for financing purposes and the related
increase in our stockholders equity.

Interest Income: At December 31, 2008, we had cash and cash equivalents of $21.5 million
and investments, classified as short-term and long-term, with a par value of approximately $26.0 million. Although we maintained a higher average cash and investments level over the year, interest earned increased by only $0.3 million, reflecting
general reductions in interest rates and the shift of our holdings, other than ARS, into Treasury funds and similar investments.

Other
expense. Based on a fair value analysis, we recorded an other-than-temporary impairment charge related to our investment in ARS of approximately $6.4 million, offset by a gain of $2.0 million recorded based on the fair value of the ARS rights
obtained related to the future redemption of certain of those ARS.

Comparison of Years ended December 31, 2007 and 2006



|                                   |  |                                   |        |                                   |   |                      |  |         |       |  |     |  
|---------------------------------- |  | --------------------------------- | ------ | --------------------------------- | - | -------------------- |  | ------- | ----- |  | --- | -
|(in thousands, except percentages) |  | For theYear endedDecember 31,2007 |        | For theYear endedDecember 31,2006 |   | $ Increase(Decrease) |  | %Change |      
|Research and development expense   |  | $                                 | 12,336 |                                   | $ | 6,864                |  | $       | 5,472 |  | 80  | %
|Sales and marketing expense        |  |                                   | 1,294  |                                   |   | 642                  |  |         | 652   |  | 102 | %
|General and administrative expense |  |                                   | 2,875  |                                   |   | 2,028                |  |         | 847   |  | 42  | %
|Interest income                    |  |                                   | 1,424  |                                   |   | 863                  |  |         | 561   |  | 65  | %

Research and development expenses increased in 2007 primarily related to the advancement of
our drug candidates into more extensive clinical testing programs and the addition of new personnel during the year and the related compensation costs. As a percentage of operating expenses, research and development costs increased



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to 75% for 2007 from 72% for 2006. During 2007, we continued our manufacturing, preclinical, Phase I and Phase II activities for CH-1504 and initiated
manufacturing, formulation, preclinical, Phase II and Phase III activities for droxidopa. We also continued our preclinical activities for the portfolio of therapeutics in partnership with Active Biotech. Also contributing to the increase in
research and development costs were a $0.4 million increase in compensation and related expenses, a $0.2 million increase in general contractor and outside services expense and an expense of approximately $0.4 million related to warrants for 250,000
shares of our common stock, dated May 2006, the vesting of which was conditioned on an event that occurred in January 2007.

Sales and
marketing expenses. We had no formalized selling activities for the year ended December 31, 2007. The increase is primarily related to a $0.4 million increase in costs for promotional and market research related to droxidopa and its
potential indications, a $0.3 million increase in compensation and related expenses related to the hiring of our Vice President of Sales and Marketing and increases in non-cash stock-based compensation.

General and administrative expenses. The $0.8 million increase in general and administrative expenses consists of a $0.2 million increase in
compensation and related expenses reflecting full year compensation for employees hired during 2006; a $0.4 million increase in non-cash stock-based compensation based on grants made in February 2007, the fair values of which reflect our increased
stock price and volatility; and a $0.2 million increase in professional and consulting fees mainly related to our implementation of and compliance with Rule 404 of the Sarbanes-Oxley Act.

Interest income. During 2007, we raised approximately $57.2 million, net of expenses, through the sale of our common stock in two financing
transactions. As such, our cash and short-term investments at December 31, 2007 of approximately $62.7 million reflects our cash and short term investments at December 31, 2006 and the infusion of capital from these financing transactions
offset by approximately $10.7 million used to fund operating activities during the year. Accordingly, interest earned on cash and short-term investments increased by $0.6 million to $1.4 million for 2007.

Liquidity and Capital Resources

From inception to
December 31, 2008, we have incurred an aggregate net loss of approximately $69.8 million as a result of expenses similar in nature to those described above.

As of December 31, 2008, we had working capital of approximately $20.2 million, cash and cash equivalents of approximately $21.5 million, short-term investments of approximately $10.3 million and investments
classified as long-term under the terms of a settlement agreement of approximately $11.3 million. We have financed our operations primarily through sales of our stock and, to a much lesser extent, through the issuance of our common stock pursuant to
option or warrant exercises. Cash on hand results primarily from previous financing activities offset by funds utilized for operating and investing activities. Our financing activities are more fully described in Financings below.

Auction Rate Securities

At
December 31, 2008, our short-term investments of $10.3 million and our long-term investments of $11.3 million consisted of the fair value of principal invested in certain ARS. The ARS held by us are private placement securities with long-term
nominal maturities for which the interest rates are reset through a dutch auction on 28 or 35 day cycles. Although the monthly auctions had historically provided a liquid market for these securities, in early 2008, with the liquidity issues in the
global credit and capital markets, auctions for these, and similar, securities began to fail and by March 2008, market activity had essentially ceased. Our investments in these securities represent interests in collateralized debt obligations
supported by pools of structured credit instruments consisting of student loans. None of the collateral for the ARS held by us includes mortgage, credit card or insurance securitizations. As of December 31, 2008, our ARS holdings had a par
value of approximately



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$26 million and all but approximately $4.4 million were AAA/Aaa rated and insured by the Federal Family Education Loan Program (FFELP) and/or
over-collateralized by more than 10%. Of the remaining $4.4 million, all were collateralized at 100% and, consistent with our investment policy, $0.75 million carried an A rating, $1.15 million carried an Aa3/AAA rating and the remainder carried
AAA/Aaa ratings.

Since early February 2008 we have experienced difficulty in liquidating our ARS as the amount of securities submitted for
auction has exceeded the market demand and auctions began to fail. When the auctions for these securities fail, the investments are not readily convertible into cash until a future auction is successful, secondary markets emerge, the securities are
redeemed by the issuer or they mature. Although we are experiencing a lack of liquidity for these securities at the present time, we anticipate, based on continuing discussions with our investment advisors, that liquidity for some of our holdings
might be realized through secondary market transactions. Such transaction might be effected at a significant discount to the par value of such securities.

While Banc of America Securities announced a settlement with various regulatory agencies in October 2008, such settlement had no specific commitments to assist us in achieving liquidity in our ARS holdings at Banc of
America. It did indicate that Banc of America would use its best efforts to provide liquidity to institutional investors and business customers with accounts valued at $15 million or more, though no specific guidance on how this was to be
accomplished was given. We continue to work with Banc of America to determine how they might assist us in achieving liquidity for these investments.

In October 2008, we received notice that a tender offer, for redemption at 93.5% of par value, had been made by an issuer on certain of our ARS holdings. Then, in December 2008, we were informed that the Tender Offer
had expired without fulfillment of the applicable minimum tender conditions. So, while initially encouraged that the tender offer was evidence of issuer activity in the market and potential redemptions of the securities covered by the tender and
perhaps others held by us the withdrawal reflects continued significant uncertainties in the overall market conditions. Concurrently, in December, 2008, we learned that interest had been expressed in the secondary markets regarding the potential
purchase of Mississippi Higher Ed ARS, of which we had a position with a par value of $2.5 million. Subsequently, in January 2009, we successfully liquidated our holding in this security on the secondary markets at 83% of its par value, or for
$2.075 million.

After significant review and investigation on our part concerning the status of the ARS market and taking into
consideration the complexities of the market and the valuation factors as set forth in the guidelines of Statement of Financial Accounting Standard No. 157 (SFAS 157), Fair Value Measurements,we engaged the services of a third party
valuation expert to assist in and provide data used in establishing estimated fair values for the ARS held at Banc of America Securities at December 31, 2008. Given our inability to hold these securities indefinitely and that we could liquidate
those ARS during 2009, we continue to treat these ARS as available-for-sale investments and as a current asset on our consolidated balance sheet. Based on our estimate of the fair value, in conjunction with information provided by our third party
expert, we determined that the fair value of these ARS was approximately 71.2% of par value at December 31, 2008. As a result, we recorded an other-than-temporary impairment loss in the quarter ended December 31, 2008 of approximately $1.7
million and an other-than-temporary impairment loss for the year ended December 31, 2008 of approximately $4.1 million related to these securities.

It should also be noted that our ability to hold these assets may continue to change. If additional successful secondary market exchanges for the holdings at Banc of America Securities are completed during 2009 at
lower values or should information arise on other means of liquidating or leveraging the Banc of America holdings, the valuations calculated at December 31, 2008 may need to be adjusted. While continuing to explore potential liquidity solutions
with Banc of America, we anticipate liquidating these holdings in ARS in order to maintain our financing strategies and considering our relative inability to hold the securities to maturity or full recovery of value.



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During the fourth quarter of 2008, we finalized the details of our settlement agreement with UBS AG under
the published terms. We are classified as an institutional investor for purposes of the settlement agreement. In November 2008, we accepted the terms of the settlement agreement from UBS for ARS Rights (the ARS Rights) for
our illiquid ARS holdings maintained at UBS as of February 13, 2008. The ARS Rights provide us with the ability to sell the ARS, along with the ARS Rights, to UBS at the par value of the ARS no earlier than June 30, 2010 and expire on
July 2, 2012. UBS also agreed that an affiliate would provide us with a no net-cost line of credit for up to a portion of the market value (as determined by UBS) of our ARS holdings as of October 31, 2008.

In November 2008, we finalized and submitted documents to UBS to initiate the line of credit account and received notification that funds were available
under the account in early December 2008. We then requested and, in December 2008, received a wire transfer into our cash operating account of approximately $7.3 million and recorded a corresponding long-term liability. Subsequently, in March 2009,
the line of credit was amended to provide us with a credit line of up to $11.575 million, including the $7.3 million outstanding at December 31, 2008, with our UBS ARS investments remaining pledged as collateral. Though the loan is payable on
demand, if the UBS affiliate should exercise its right to demand repayment of any portion of the loan prior to the date we can exercise our ARS Rights, UBS and its affiliates would be required to arrange for alternative financing on terms and
conditions substantially the same as those contained in the line of credit agreement. If alternative financing cannot be established, then UBS AG, or one of its affiliates, will purchase our pledged UBS ARS at par. As a result, the loan
and any alternative financing will not be payable by us prior to the time that we are able to exercise our UBS ARS Rights in accordance with our agreement with UBS. We expect to repay the line of credit with the proceeds from the exercise of
those ARS Rights. Proceeds of any sales of our UBS ARS will first be applied to repayment of the line of credit with the balance, if any, deposited into our account.

Recognizing that the ARS Rights act as an economic hedge against any further price movement in our ARS holdings, we elected the fair value option under Statement of Financial Accounting Standards No. 159
(SFAS 159), The Fair Value Option for Financial Assets and Liabilitiesto mitigate volatility in reported earnings due to the relationship between the ARS Rights and the ARS. We will adjust the ARS Rights to fair value at each
financial statement date with corresponding changes in fair value reported in earnings. Simultaneously, we elected a one-time transfer of the ARS covered under the settlement agreement with UBS from the available-for-sale category to the trading
category recognizing the unprecedented failure of the entire market for ARS. This election allows all future movements in the fair value of the ARS to be reported in earnings, creating accounting symmetry with the ARS Rights until the settlement is
realized. We also reclassified the UBS ARS from short term investment to long-term investments based on the terms of the settlement agreement and our resulting expectation of full liquidity in June 2010.

Based on our estimate of fair value, utilizing a discounted cash flow model that approximates the values determined by UBS under their independent
methodology, we recorded an additional other-than-temporary impairment charge of $1.0 million for the quarter ended December 31, 2008. Offsetting this impairment charge, we recorded other income and a corresponding long-term asset for the fair
value of the ARS Rights obtained in November 2008 of $2.0 million. For 2008, the recording of the gain from the ARS Rights and the recognition of other-than-temporary impairment losses resulted in a $0.2 million net impact on the consolidated
statements of operations.

The valuation of our ARS investment portfolio is sensitive to market conditions and is based on our best
estimate given the facts available at the time of the estimate. The assumptions utilized in the estimate of fair value are difficult to predict and can change significantly, providing materially different values. In addition, actual market
exchanges, if any, may occur at materially different amounts. Given the uncertainties of selling the securities held with Banc of America Securities on the secondary market, the realized value could vary from our current valuations by material
amounts, either favorably or unfavorably.

We have incurred negative cash flows from operations since inception. We have spent, and expect
to continue to spend, substantial amounts in connection with implementing our business strategy, including our



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planned product development efforts, our clinical trials and our efforts to secure opportunities for strategic alliances. Our continued operations will
depend on whether we are able to raise additional funds through various potential sources, such as equity and debt financing or strategic alliances. Such additional funds might not become available on acceptable terms, or at all, and there can be no
assurance that any additional funding that we do obtain will be sufficient to meet our needs in the long term. From inception through December 31, 2008 we had losses of $69.8 million. We had a net loss of $35.1 million and $15.1 million for the
years ended December 31, 2008 and 2007, respectively, and we anticipate losses for the foreseeable future.

Actual losses will depend
on a number of considerations including:



| |  |  | the pace and success of preclinical development and clinical trials for droxidopa, antifolates and other product candidates;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------



| |  |  | our ability to leverage or liquidate our holdings in ARS;
| | - |  | ---------------------------------------------------------



| |  |  | seeking regulatory approval for our various product candidates;
| | - |  | ---------------------------------------------------------------



| |  |  | possible out-licensing of our product candidates;
| | - |  | -------------------------------------------------



| |  |  | discussions with regulatory agencies concerning the design of our clinical trials
| | - |  | ---------------------------------------------------------------------------------



| |  |  | our ability to identify and recruit patients into our clinical trials at costs consistent with our current estimates;
| | - |  | ---------------------------------------------------------------------------------------------------------------------



| |  |  | the pace of development of new intellectual property for our existing product candidates;
| | - |  | -----------------------------------------------------------------------------------------



| |  |  | in-licensing and development of additional product candidates;
| | - |  | --------------------------------------------------------------



| |  |  | implementing additional internal systems and infrastructure; and
| | - |  | ----------------------------------------------------------------



| |  |  | hiring additional personnel.
| | - |  | ----------------------------

Financings

On November 8, 2007, we raised gross proceeds of approximately $48.9 million through the sale of 7,388,172 shares of our
common stock in a registered direct offering. These shares were offered pursuant to our shelf registration statement as filed with the Securities and Exchange Commission or SEC, under which we were able to offer shares of our common stock and
preferred stock, various series of debt securities and/or warrants to purchase any of such securities, either individually or in units, in one or more offerings, up to a total dollar amount of $60.0 million. Such registration statement became
effective as of October 11, 2007. In connection with this offering, we paid commissions and recorded or accrued other offering-related costs of approximately $3.2 million.

On March 22, 2007, we raised gross proceeds of approximately $12.5 million through the sale of 2,648,306 shares of our common stock plus warrants
for the purchase of 794,492 shares of our common stock. The aggregate fair value of these warrants was approximately $1.3 million. The warrants permit the holders to purchase the underlying common shares at $5.66 each and are exercisable in whole at
any time, or in part from time to time, for cash, for five years from the date of issuance. The warrants are redeemable at par value at our option in the event that the volume weighted-average closing price of our common stock is greater than $12.00
per share for any 20 consecutive trading days provided we give 60 business days written notice to the holders and simultaneously call all warrants on the same terms. Under the terms of the placement, we agreed to and filed a registration
statement with the SEC within 30 days of the closing for the shares of common stock sold and the shares of common stock underlying the warrants and such registration became effective on August 7, 2007. In connection with this offering, we paid
commissions and other offering-related costs of approximately $1.0 million in cash.



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On February 13, 2006, we raised gross proceeds of approximately $21.5 million through the sale of
7,166,666 shares of our common stock plus warrants for the purchase of 2,149,999 shares of our common stock. The aggregate fair value of these warrants was approximately $1.1 million. The warrants permit the holders to purchase the underlying common
shares at $4.20 each and are redeemable at our option in the event that the volume weighted average closing bid price of our common stock for any 20 consecutive trading days is at least $9.00 per share. In connection with this offering, we paid
commissions and other offering-related costs of approximately $1.6 million in cash and issued warrants to the placement agent for the purchase of 716,666 shares of our common stock with an exercise price of $3.30 per share, or 110% of the price of
the shares sold in the offering and an aggregate fair value of approximately $0.7 million. Under the terms of the financing, we filed a registration statement with the SEC within 30 days of the closing for the shares of common stock sold and the
shares of common stock underlying the warrants and such registration became effective on March 29, 2006.

In December 2004, we raised
gross proceeds of approximately $14.5 million through the sale of 5,532,994 shares of our common stock. The amount raised included the conversion of a $1.7 million stockholder loan along with accrued interest, for which a total of 677,919 shares of
common stock were issued. In connection with this offering, we paid commissions and other offering-related costs of approximately $1.0 million in cash and issued warrants to the placement agent for the purchase of 483,701 shares of our common stock
with an aggregate fair value of approximately $14,000.

License Agreement and Development Agreement Obligations

In March 2004, we entered into a License Agreement with Dr. M. Gopal Nair, Ph.D., of the University of South Alabama College of Medicine, for rights
to use, produce, distribute and market products derived from an invention by Dr. Nair, claimed in US Patent # 5,912,251, entitled metabolically inert anti-inflammatory and antitumor antifolates, designated by us as CH-1504 and
related compounds. The license provides us exclusive, worldwide (excluding India) rights for these compounds.

In 2004, as consideration
for these rights, we paid $150,000 and issued Dr. Nair and his designees 471,816 shares of common stock at an estimated aggregate value of $402. As additional consideration, we agreed to pay to Dr. Nair and or his designees:
(1) royalties on the sales should any compounds be approved for commercial sale; (2) milestone payments, payable upon achievement of clinical milestones; and (3) payments to be made on specified anniversary dates, some of which may be
payable in equity, at our discretion, through 2009. We made milestone payments as required by the agreement of $100,000 each in March 2006 and 2005. In April 2007, we issued 26,643 shares of our common stock, subject to trading restrictions, at a
value of approximately $5.63 per share, in settlement of the $150,000 annual milestone payment for 2007. In March 2008, we made a milestone payment of $100,000 related to patient dosing in a Phase 2 study as required by the agreement. In April 2008,
we issued 30,612 shares of common stock, subject to trading restrictions, at a value of approximately $4.90 per share, in settlement of the 2008 anniversary milestone payment of $150,000. At December 31, 2008, remaining future milestone and
anniversary payments, which are subject to our rights to terminate the license agreement, totaled approximately $1.5 million.

The license
agreement includes certain other covenants, which require us to, among other things, maintain and prosecute patents related to the license; use commercially reasonable best efforts to bring the licensed product to market as soon as reasonably
practicable and continue active, diligent marketing efforts; and prepare and provide to the licensors certain reports concerning our development and commercialization efforts. In the event we fail to carry out our responsibilities under the license
agreement, the licensors may terminate the license. We may elect to abandon the maintenance and prosecution of any patent applications or issued patents and we retain the right to terminate the license agreement in whole or as to any portion by
providing written notice of such intentions to the licensor. The license agreement may also be terminated in the event we fail to make a scheduled milestone or royalty payment, we otherwise materially breach the license agreement, or if we become
involved in a bankruptcy, insolvency or similar proceeding, provided that we are entitled to notice of such intention to terminate and an opportunity to cure. Regardless, the license agreement shall expire concurrent with the date of the last to
expire claim contained in the patent rights.



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In May 2006, we entered into an agreement with Dainippon Sumitomo Pharma Co., Ltd. (DSP) for a worldwide,
exclusive, sub-licensable license and rights to certain intellectual property and proprietary information relating to droxidopa including, but not limited to all information, formulations, materials, data, drawings, sketches, designs, testing and
test results, records and regulatory documentation. As consideration for these rights, we paid DSP $100,000 and issued 63,131 shares of our common stock, with a value of approximately $4.35 per share, or $274,621. As additional consideration, we
agreed to pay DSP and or its designees: (1) royalties on the sales should any compound be approved for commercial sale; and (2) milestone payments, payable upon achievement of milestones as defined in the agreement. In January 2007, we
received notification that the FDA had granted orphan drug designation for droxidopa for the treatment of symptomatic neurogenic orthostatic hypotension. Based on the terms of the DSP agreement, the granting of orphan drug designation for droxidopa
triggered a milestone payment to DSP of $250,000. We made such payment in February 2007. In February 2008, we made a milestone payment under the agreement of $500,000 related to patient dosing in a Phase 3 study. At December 31, 2008, remaining
potential future milestone payments, subject to our right to terminate the license agreement, totaled $3.25 million.

Subsequent to
execution of the agreement, we agreed that DSP will initiate, and we will fund, activities focused on modifying the manufacturing capabilities of DSP in order to expand capacity and comply with cGMP regulations and all existing manufacturing
requirements of the FDA. Such activities are currently ongoing and shall continue into 2009.

In May 2006, we entered into a development
and commercialization agreement (the Development Agreement) with Active Biotech AB to co-develop and commercialize the I-3D portfolio of orally active, dihydroorotate dehydrogenase (DHODH) inhibiting compounds for the treatment of
autoimmune diseases and transplant rejection. Under the terms of the license and co-development agreement, an initial payment of $1.0 million was made to Active Biotech during 2006 with such funds utilized to cover the initial costs of research and
development efforts jointly approved by both parties. At December 31, 2006, we had expensed the entire $1.0 million payment. At December 31, 2007 we had expensed cumulative costs of $1.0 million under the program, in excess of the initial
payment of $1.0 million, related to costs of research and development. During 2008, we ceased joint discovery efforts with Active Biotech on this portfolio and, accordingly, recorded no costs related to this program during 2008. In April 2008, we
entered into a termination and assignment agreement (the Termination Agreement) with Active Biotech, whereby Active Biotech discontinued its participation in the I-3D co-development program and assigned its entire right, title and
interest in the portfolio to us in exchange for royalties on future sales. The Termination Agreement also eliminated our obligation related to payment of potential future development milestones under the Development Agreement.

Current and Future Financing Needs

We have
incurred negative cash flow from operations since inception. We have spent, and expect to continue to spend, substantial amounts in connection with implementing our business strategy, including our planned product development efforts, our clinical
trials, our research and discovery efforts and our marketing and branding initiatives. Based on our resources at December 31, 2008 and our projection of spending needs during 2009, we believe that we have sufficient capital resources to meet
our operating needs into the fourth quarter of 2009.

We have based our estimate on assumptions that might prove to be incorrect. The
extent of our available resources and the actual amount of funds we will need to operate is subject to many factors, some of which might be beyond our control. These factors include the following:



| |  |  | our ability to obtain liquidity from ARS held at Banc of America Securities;
| | - |  | ----------------------------------------------------------------------------



| |  |  | the progress of our research activities;
| | - |  | ----------------------------------------



| |  |  | the number and scope of our research programs;
| | - |  | ----------------------------------------------



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| |  |  | opportunities to sub-license our existing compounds to others;
| | - |  | --------------------------------------------------------------



| |  |  | our ability to maintain current research and development programs and to establish new research and development and licensing arrangements;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our ability to achieve our milestones under licensing arrangements;
| | - |  | -------------------------------------------------------------------



| |  |  | the costs involved in prosecuting and enforcing patent claims and other intellectual property rights; and
| | - |  | ---------------------------------------------------------------------------------------------------------



| |  |  | the costs and timing of regulatory approvals.
| | - |  | ---------------------------------------------

Our estimate that resources on hand at December 31, 2008 are likely to meet our needs into the fourth quarter of 2009 is based on the assumption that we will gain liquidity from our ARS held with Banc of America
Securities on existing secondary markets at discounts approximately equivalent to our current impairment recorded for these assets. While this estimate does not rely on additional sources of liquidity, we are actively pursuing such opportunities in
anticipation of ongoing liquidity needs. Potential sources of additional liquidity include strategic relationships, out-licensing of our products, public or private sales of equity or debt, the exercise of warrants by our warrant holders and other
sources. We might seek to access the public or private equity markets when and if conditions are favorable due to our long-term capital requirements. We do not have any committed sources of financing at this time, and it is uncertain whether
additional funding will be available when we need it on terms that will be acceptable to us, or at all. If we raise funds by selling additional shares of common stock or other securities convertible into common stock, the ownership interest of our
existing stockholders will be diluted. If we are not able to obtain financing when needed, we might be unable to carry out our business plan. As a result, we might have to significantly delay certain activities or limit our operations and our
business, financial condition and results of operations would be materially harmed. Moreover, if we do not obtain additional financing or other liquidity by mid-2009, we would expect to delay certain discretionary development activity and certain
activities otherwise planned for the commercialization of droxidopa in the US market.

Off-Balance Sheet Arrangements

We do not have any unconsolidated entities, and accordingly, we have not entered into any transactions with unconsolidated entities whereby we have
financial guarantees, subordinated retained interests, derivative instruments or other contingent arrangements that expose us to material continuing risks, contingent liabilities, or any other obligations under a variable interest in an
unconsolidated entity that provides us with financing, liquidity, market risk or credit risk support.

Contractual Obligations and Commitments

As of December 31, 2008, we have known contractual obligations and commitments of approximately $25.6 million, primarily related
to contracted research and development activities. To facilitate an understanding of our contractual obligations and commercial commitments, the following data is provided as of December 31, 2008:



|                            |  |                        |            |          |   |            |  |           |           |                  |   |         |  |   |  
|--------------------------- |  | ---------------------- | ---------- | -------- | - | ---------- |  | --------- | --------- | ---------------- | - | ------- |  | - | -
|                            |  | Payments due by period
|Category                    |  | Total                  |            | < 1 Year |   | 1-3 Years  |  | 3-5 Years |           | More than5 Years
|Operating lease obligations |  | $                      | 1,129,847  |          | $ | 255,031    |  | $         | 493,672   |                  | $ | 381,144 |  | $ | 
|Purchase obligations        |  |                        | 24,456,727 |          |   | 22,144,041 |  |           | 2,312,686 |                  |   |        |  |   | 
|                            |  |                        |            |          |   |            |  |           |           |                  |   |         |  |   |  
|Total                       |  | $                      | 25,586,574 |          | $ | 22,399,072 |  | $         | 2,806,358 |                  | $ | 381,144 |  | $ | 
|                            |  |                        |            |          |   |            |  |           |           |                  |   |         |  |   |  

In addition, we have entered into certain other agreements that, as of December 31, 2008,
might require we make contingent milestone payments of up to approximately $4.9 million over the life of the agreements upon the achievement of certain clinical or commercial milestones. Such future payments are subject to our right to terminate the
agreements. In the event that the milestones are not achieved, we elect not to pursue further testing



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of the drug candidate or we terminate such agreements, we will have no further obligations under the agreements. The uncertainty relating to the timing and
occurrence of the commitments described prevents us from including them in the table above.

Critical Accounting Policies

Our managements discussion and analysis of our financial condition and results of operations is based on our financial statements, which have been
prepared in accordance with accounting principles generally accepted in the United States of America. Our significant accounting policies are more fully described in Note 1 to the consolidated financial statements accompanying this Annual Report on
Form 10-K. The following accounting policies are critical in fully understanding and evaluating our reported financial results.

Use of Estimates

The preparation of financial statements in conformity with accounting principles generally accepted in the United States of America
requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent liabilities at the date of the financial statements as well as the reported revenue and expenses during
the reporting periods. On an ongoing basis, management evaluates its estimates and judgments. Management bases estimates on historical experience and on various other factors that it believes are reasonable under the circumstances, the results of
which form the basis for making judgments about the carrying value of assets and liabilities that are not readily apparent from other sources. Actual results might differ from these estimates under different assumptions or conditions.

Research and Development

Research and
development expenditures are expensed as incurred. We often contract with third parties to facilitate, coordinate and perform agreed upon research and development activities. To ensure that research and development costs are expensed as
incurred, we measure expense based on work performed for the underlying contract, typically utilizing a percentage-of-completion approach, and record prepaid assets or accrue expenses on a monthly basis for such activities based on the measurement
of liability from expense recognition and the receipt of invoices.

These contracts typically call for the payment of fees for services at
the initiation of the contract and/or upon the achievement of certain milestones. In the event that we prepay fees for future milestones, we record the prepayment as a prepaid asset and amortize the asset into research and development expense
over the period of time the contracted research and development services are performed. Most fees are incurred throughout the contract period and are expensed based on their percentage of completion at a particular date.

These contracts generally include pass through fees. Pass through fees include, but are not limited to, regulatory expenses, investigator fees,
travel costs, and other miscellaneous costs including shipping and printing fees. Because these fees are incurred at various times during the contract term and they are used throughout the contract term, we record a monthly expense allocation
to recognize the fees during the contract period. Fees incurred to set up the clinical trial are expensed during the setup period.

Costs related to the acquisition of technology rights and patents for which development work is still in process are expensed as incurred and considered a component of research and development costs.

Accounting for Stock-Based Compensation

We
account for our employee stock options and warrants using the fair value method as prescribed in Statement of Financial Accounting Standards No. 123R (SFAS 123R), Share-based Payment. SFAS 123R defines a fair value based
method of accounting for employee stock options or similar equity instruments. In



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determining the fair value of the equity instrument, we considered, among other factors, (i) the risk-free interest rate, (ii) the expected life of
the options granted, (iii) the anticipated dividend yield, (iv) the estimated future volatility of the underlying equity and (v) anticipated future forfeitures. To determine the risk-free interest rate, we utilized the U.S. Treasury
yield curve in effect at the time of grant with a term consistent with the expected term of our awards. We estimated the expected life of the options granted based on anticipated exercises in future periods assuming the success of our business model
as currently forecasted. The expected dividends reflect our current and expected future policy for dividends on our common stock. To determine the expected stock price volatility for our stock options, we examined historical volatilities for
industry peers as we do not have sufficient trading history for our common stock. We will continue to analyze the expected stock price volatility and expected term assumption as more historical data for our common stock becomes available. Given the
limited service period for our current employees and the senior nature of the roles for those employees, we estimated that we would experience no forfeitures for those options currently outstanding. Our results include non-cash compensation expense
as a result of the issuance of stock option grants utilizing this method. We expect to record additional non-cash compensation expense in the future, which might be significant, particularly if our stock price increases. Due to the limited amount of
historical data available to us, particularly with respect to stock-price volatility, employee exercise patterns and forfeitures, actual results could differ from our assumptions.

Available-for-Sale and Trading Investments

Investments consist of investments in certain
auction rate securities (ARS). ARS are generally long-term debt instruments for which interest rates are reset through a dutch auction process that occurs at pre-determined calendar intervals, generally each 28 or 35 days. We account for
such investments utilizing Statement of Financial Accounting Standards No. 115 (SFAS 115), Accounting for Certain Investments in Debt and Equity Securities.SFAS 115 requires that we evaluate whether an event or change in
circumstances has occurred during the period that may have a significant adverse effect on the fair value of the investment (an impairment indicator) at the balance sheet date. If an impairment indicator is present, we would perform an
analysis based on factors as prescribed by Statement of Financial Accounting Standards No. 157 (SFAS 157), Fair Value Measurements, to determine the fair value of such investments at the balance sheet date. If a decline in
value had occurred, further analyses would be performed to determine whether such decline is temporary or other-than-temporary. If it is determined that the decline in value is other-than-temporary, then an impairment loss would be recognized.

Fair Value Measurements

Effective January 1, 2008, we adopted SFAS 157 for financial assets and liabilities and any other assets and liabilities carried at fair value. This pronouncement defines fair value, establishes a framework for measuring fair value and
expands disclosures about fair value measurements.

As defined in SFAS 157, fair value is based on the price that would be received to sell
an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. In order to increase consistency and comparability in fair value measurements, SFAS 157 establishes a fair value hierarchy that
prioritizes observable and unobservable inputs used to measure fair value into three broad levels, which are described below:



| |  |  | Level 1: Quoted prices (unadjusted) in active markets that are accessible at the measurement date for assets or liabilities. The fair value hierarchy gives the
highest priority to Level 1 inputs.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Level 2: Observable prices that are based on inputs not quoted on active markets, but corroborated by market data.
| | - |  | ------------------------------------------------------------------------------------------------------------------



| |  |  | Level 3: Unobservable inputs are used when little or no market data is available. The fair value hierarchy gives the lowest priority to Level 3 inputs.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------



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ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

We invest our cash in a variety of financial instruments in order to preserve principal and liquidity while maximizing returns and we do not invest in
financial instruments or their derivatives for trading or speculative purposes. To minimize the exposure due to adverse shifts in interest rates, we maintain investments of shorter maturities. Our investment guidelines include security type, credit
quality and maturity and are intended to limit market risk by restricting our investments to high quality debt instruments with relatively short maturities. At December 31, 2008, our investments primarily consisted of Treasury funds with an
average maturity under 90 days and ARS with long-term nominal maturities for which the interest rates are reset through a dutch auction each month or, should those auctions fail, as determined by contractual obligation. All investments to date have
been made in U. S. dollars and accordingly, we do not have any exposure to foreign currency rate fluctuations.

Our interest income is
sensitive to changes in the general level of interest rates in the United States, particularly since our investments are and will be in short-term investments. To assess our interest rate risk, we performed a sensitivity analysis projecting
potential future interest earnings on investments in which we estimated the impact of a 1%, or 100 basis point, increase or decrease in our average interest rate over a 12 month time horizon. This analysis resulted in a potential effect of
approximately $240,000 on the interest earned on investments.

At December 31, 2008, we had investments in ARS with par value of $26
million and an estimated fair value of $19.7 million and ARS Rights with an estimated fair value of $2.0 million. Historically, ARS were priced at par, as per industry convention, based on observed or reported verifiable trades and provided a liquid
market for these ARS investments. However, the recent liquidity issues have virtually shut down most active market transactions for ARS. Our investments in ARS represent interests in collateralized debt obligations supported by pools of student
loans, typically over-collateralized and/or insured by the FFELP. None of the ARS investments in our portfolio were backed by sub-prime mortgage loans or other collateral with exposure to certain current market conditions. However, liquidity issues
experienced recently in global credit and capital markets have prevented us from liquidating our ARS investments as the amount of securities submitted for sale at recent ARS auctions has exceeded the market demand, though they continue to pay
interest according to their stated terms. Although insufficient demand related to the ARS auctions is expected to continue, we anticipate, based on continuing discussions with our investment advisors, that liquidity for those of our securities not
covered under a settlement agreement with UBS might possibly be realized through redemptions by the issuing agencies, our increased participation in secondary markets and/or other means. In the event that we are unable to sell those investments at
or above our carrying value, these securities may not provide us a liquid source of cash or might require us to record additional impairment to the asset value.



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ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

(a) The financial statements required to be filed pursuant to this Item 8 are appended to this Annual Report on Form 10-K. An index of the financial
statements filed herewith is found on page 53.

(b) The unaudited quarterly financial data for the two-year period ended December 31,
2008 is as follows:



|                                     |  |                              |            |   |               |   |            |              |  |   |               |   |  |   |            |  
|------------------------------------ |  | ---------------------------- | ---------- | - | ------------- | - | ---------- | ------------ |  | - | ------------- | - |  | - | ---------- | -
|                                     |  | Year ended December 31, 2007 |           
|                                     |  | FirstQuarter                 |            |   | SecondQuarter |   |            | ThirdQuarter |  |   | FourthQuarter |  
|Operating expenses                   |  | $                            | 4,033,316  |   |               | $ | 3,481,046  |              |  | $ | 3,550,306     |   |  | $ | 5,440,719  |  
|Loss from operations                 |  |                              | (4,033,316 | ) |               |   | (3,481,046 | )            |  |   | (3,550,306    | ) |  |   | (5,440,719 | )
|Net loss                             |  |                              | (3,835,880 | ) |               |   | (3,163,427 | )            |  |   | (3,242,816    | ) |  |   | (4,839,422 | )
|Basic and diluted loss per share (a) |  | $                            | (0.19      | ) |               | $ | (0.14      | )            |  | $ | (0.14         | ) |  | $ | (0.18      | )
|                                     | 
|                                     |  | Year ended December 31, 2008 |           
|                                     |  | FirstQuarter                 |            |   | SecondQuarter |   |            | ThirdQuarter |  |   | FourthQuarter |  
|Operating expenses                   |  | $                            | 7,838,728  |   |               | $ | 7,776,809  |              |  | $ | 8,276,681     |   |  | $ | 8,505,094  |  
|Loss from operations                 |  |                              | (7,838,728 | ) |               |   | (7,776,809 | )            |  |   | (8,276,681    | ) |  |   | (8,505,094 | )
|Other expenses                       |  |                              | (1,566,246 | ) |               |   |           |              |  |   | (2,109,927    | ) |  |   | (714,314   | )
|Net loss                             |  |                              | (8,675,526 | ) |               |   | (7,317,003 | )            |  |   | (10,080,394   | ) |  |   | (9,013,228 | )
|Basic and diluted loss per share (a) |  | $                            | (0.29      | ) |               | $ | (0.24      | )            |  | $ | (0.34         | ) |  | $ | (0.30      | )



|(a) | Basic and diluted loss per common share for each of the quarters presented above is based on the respective weighted average number of common shares for the quarters. As such, the
sum of the quarters may not necessarily be equal to the full year loss per share amount. Basic and diluted loss per share are identical since potentially dilutive securities are excluded from the calculations, as the effect would be anti-dilutive
for all periods presented.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND
FINANCIAL DISCLOSURE

None.

ITEM 9A. CONTROLS AND PROCEDURES

Disclosure controls and procedures (as defined in Exchange Act Rule 13a-15(e)) are designed
only to provide reasonable assurance that they will meet their objectives that information required to be disclosed in our Exchange Act reports is recorded, processed, summarized and reported within the time periods specified in the SECs rules
and forms, and that such information is accumulated and communicated to our management, including our Chief Executive Officer and Chief Financial Officer, as appropriate, to allow timely decisions regarding required disclosures. As of the end
of the period covered by this report, we carried out an evaluation, under the supervision and with the participation of our management, including our Chief Executive Officer and Chief Financial Officer, of the effectiveness of the design and
operation of our disclosure controls and procedures (as defined in Rule 13a-15(e)) pursuant to Exchange Act Rule 13a-15. Based upon that evaluation and subject to the foregoing, our Chief Executive Officer and Chief Financial Officer have
concluded that our disclosure controls and procedures were effective as of December 31, 2008.

Changes in internal control over financial
reporting.

Management has determined that, as of December 31, 2008, there were no changes in our internal control over financial
reporting that occurred during our fiscal quarter then ended that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.



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Managements Report on Internal Control Over Financial Reporting

Our management is responsible for establishing and maintaining adequate internal control over financial reporting, as such term is defined in Rule
13a-15(f) under the Securities Exchange Act of 1934. Our internal control over financial reporting is designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external
purposes in accordance with accounting principles generally accepted in the United States. However, all internal control systems, no matter how well designed, have inherent limitations. Therefore, even those systems determined to be effective can
provide only reasonable assurance with respect to financial statement preparation and reporting.

Management assessed the effectiveness of
our internal control over financial reporting as of December 31, 2008. In making this assessment, management used the criteria set forth by the Committee of the Sponsoring Organizations of the Treadway Commission (COSO) in Internal
Control-Integrated Framework and the Guidance for Smaller Public Companies as published by COSO in June 2006. Based on our assessment, management believes that we maintained effective internal control over financial reporting as of December 31,
2008, based on those criteria.

Ernst & Young LLP, our independent registered public accounting firm, which has audited the
financial statements included in Part IV, Item 15 of this report, has also audited our internal control over financial reporting as of December 31, 2008, as stated in their report, which is included below.



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Report of Independent Registered Public Accounting Firm on Internal Control over Financial Reporting

The Board of Directors and Stockholders

Chelsea Therapeutics
International, Ltd. and Subsidiary

We have audited Chelsea Therapeutics International, Ltd. and Subsidiarys internal control over
financial reporting as of December 31, 2008, based on criteria established in Internal ControlIntegrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (the COSO criteria). Chelsea Therapeutics
International, Ltd. and Subsidiarys management is responsible for maintaining effective internal control over financial reporting, and for their assessment of the effectiveness of internal control over financial reporting included in the
accompanying Managements Report on Internal Control Over Financial Reporting. Our responsibility is to express an opinion on the Companys internal control over financial reporting based on our audit.

We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we
plan and perform the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects. Our audit included obtaining an understanding of internal control over financial
reporting, assessing the risk that a material weakness exists, testing and evaluating the design and operating effectiveness of internal control based on the assessed risk, and performing such other procedures as we considered necessary in the
circumstances. We believe that our audit provides a reasonable basis for our opinion.

A companys internal control over financial
reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A
companys internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the
assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of
the company are being made only in accordance with authorizations of management and directors of the company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use or disposition of the
companys assets that could have a material effect on the financial statements.

Because of its inherent limitations, internal control
over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree
of compliance with the policies or procedures may deteriorate.

In our opinion, Chelsea Therapeutics International, Ltd. and Subsidiary
maintained, in all material respects, effective internal control over financial reporting as of December 31, 2008, based on the COSO criteria.

We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the consolidated balance sheet of Chelsea Therapeutics International, Ltd. and Subsidiary (a development stage company)
as of December 31, 2008, and the related consolidated statements of operations, changes in stockholders equity, and cash flows for the year then ended, and for the period April 3, 2002 (inception) through December 31, 2008 of
Chelsea Therapeutics International, Ltd. and Subsidiary and our report dated March 3, 2009, expressed an unqualified opinion thereon that included an explanatory paragraph regarding Chelsea Therapeutics International, Ltd. and Subsidiarys
ability to continue as a going concern.

/s/    Ernst & Young LLP

Charlotte, North Carolina

March 3, 2009

ITEM 9B. OTHER INFORMATION

Not applicable.



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PART III

ITEM 10. DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE

Incorporated by reference from the information under the headings Proposal OneElection of Directors and Section 16(a) Beneficial Ownership Reporting Compliance in our proxy statement for the 2009 Annual Meeting
of Stockholders, which we will file with the Securities and Exchange Commission within 120 days of the end of the fiscal year to which this report relates.

The information required by Item 10 with respect to identification of our executive officers has been included in Item 1 of this Form 10-K in reliance on General Instruction G of Form 10-K and Instruction 3
to Item 401(b) of Regulation S-K.

ITEM 11. EXECUTIVE COMPENSATION

Incorporated by reference from the information under the headings Director Compensation for Fiscal Year 2008 and Executive Compensation
and Other Matters in our proxy statement for the 2009 Annual Meeting of Stockholders, which we will file with the Securities and Exchange Commission within 120 days of the end of the fiscal year to which this report relates.

ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS

Incorporated by reference from the information under the headings Security Ownership of Certain Beneficial Owners and Management and
Equity Compensation Plan Information in our proxy statement for the 2009 Annual Meeting of Stockholders, which we will file with the Securities and Exchange Commission within 120 days of the end of the fiscal year to which this
report relates.

ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE.

Incorporated by reference from the information under the headings Certain Transactions with Related Persons, Proposal OneElection
of Directors and Corporate Governance Matters in our proxy statement for the 2009 Annual Meeting of Stockholders, which we will file with the Securities and Exchange Commission within 120 days of the end of the fiscal year to
which this report relates.

ITEM 14. PRINCIPAL ACCOUNTANT FEES AND SERVICES

Incorporated by reference from the information under the heading Audit Committee Report in our proxy statement for the 2009 Annual Meeting of
Stockholders, which we will file with the Securities and Exchange Commission within 120 days of the end of the fiscal year to which this report relates.



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PART IV

ITEM 15. EXHIBITS AND FINANCIAL STATEMENTS



| | (a) | Financial Statements.
| | --- | ---------------------

The following statements are filed
as part of this report:



|                                                          |  |     
|--------------------------------------------------------- |  | ----
|                                                          |  | Page
|Reports of Independent Registered Public Accounting Firms |  | F-1 
|Consolidated Balance Sheets                               |  | F-3 
|Consolidated Statements of Operations                     |  | F-4 
|Consolidated Statements of Stockholders Equity           |  | F-5 
|Consolidated Statements of Cash Flows                     |  | F-8 
|Notes to Consolidated Financial Statements                |  | F-10

Schedules not listed above have been omitted because the information required to be set forth
therein is not applicable or is shown in the financial statements or notes thereto.



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| | (b) | Exhibits.
| | --- | ---------



|               |  |                                                                                                                                                                                     |  |                   |  |          |  |               |  |              
|-------------- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ----------------- |  | -------- |  | ------------- |  | -------------
|Exhibit Number |  | Description of Document                                                                                                                                                             |  | Registrants Form |  | Dated    |  | ExhibitNumber |  | FiledHerewith
|2.1            |  | Agreement and Plan of Merger by and among Ivory Capital Corporation, Chelsea Therapeutics, Inc. and Chelsea Acquisition Corp, dated as of January 17, 2005.                         |  | 8-K               |  | 01/17/05 |  | 2.1           |  |              
|               |  |                                                                                                                                                                                     |  |                   | 
|2.2            |  | Agreement and Plan of Merger between Ivory Capital Corporation and Chelsea Therapeutics International, Ltd., dated as of June 17, 2005.                                             |  | 8-K               |  | 07/28/05 |  | 2.2           |  |              
|               |  |                                                                                                                                                                                     |  |                   | 
|3.1            |  | Certificate of Incorporation for Chelsea Therapeutics International, Ltd.                                                                                                           |  | S-1/A             |  | 08/18/05 |  | 3.1           |  |              
|               |  |                                                                                                                                                                                     |  |                   | 
|3.2            |  | Bylaws of Chelsea Therapeutics International, Ltd.                                                                                                                                  |  | S-1/A             |  | 08/18/05 |  | 3.2           |  |              
|               |  |                                                                                                                                                                                     |  |                   | 
|10.1*          |  | License Agreement dated as of March 24, 2004 between M. Gopal Nair and Chelsea Therapeutics, Inc. (f/k/a Aspen Therapeutics, Inc.)                                                  |  | 8-K               |  | 02/16/05 |  | 10.1          |  |              
|               |  |                                                                                                                                                                                     |  |                   | 
|10.3           |  | Form of Subscription Agreement for the purchase of Series A Preferred Stock of Chelsea Therapeutics, Inc.                                                                           |  | 8-K               |  | 02/16/05 |  | 10.3          |  |              
|               |  |                                                                                                                                                                                     |  |                   | 
|10.4           |  | Chelsea Therapeutics, Inc. 2004 Stock Plan, as amended, and forms of Notice of Stock Option Grant and Stock Option Agreement, as amended.                                           |  | 10-K              |  | 03/12/07 |  | 10.4          |  |              
|               |  |                                                                                                                                                                                     |  |                   | 
|10.5           |  | Form of Subscription Agreement and Warrant for the purchase of common stock, par value $0.0001 per share, of Chelsea Therapeutics International, Ltd.                               |  | 8-K               |  | 02/17/06 |  | 10.5          |  |              
|               |  |                                                                                                                                                                                     |  |                   | 
|10.6           |  | Placement Agency Agreement dated November 28, 2005 between Chelsea Therapeutics International, Ltd. and Paramount BioCapital, Inc.                                                  |  | 10-K              |  | 03/08/06 |  | 10.6          |  |              
|               |  |                                                                                                                                                                                     |  |                   | 
|10.7           |  | Employment Agreement between Chelsea Therapeutics International, Ltd. and Dr. Simon Pedder, effective May 1, 2006.                                                                  |  | 8-K               |  | 05/01/06 |  | 10.7          |  |              
|               |  |                                                                                                                                                                                     |  |                   | 
|10.8*          |  | Development and Commercialization Agreement dated as of May 5, 2006 between Active Biotech AB and Chelsea Therapeutics International, Ltd.                                          |  | 10-Q              |  | 08/14/06 |  | 10.8          |  |              
|               |  |                                                                                                                                                                                     |  |                   | 
|10.9*          |  | Exclusive License Agreement dated May 26, 2006 between Dainippon Sumitomo Pharma Co., Ltd. and Chelsea Therapeutics, Inc.                                                           |  | 10-Q              |  | 08/14/06 |  | 10.9          |  |              
|               |  |                                                                                                                                                                                     |  |                   | 
|10.10*         |  | Finders Agreement dated May 26, 2006 between Paramount BioCapital, Inc. and Chelsea Therapeutics International, Ltd.                                                               |  | 10-Q              |  | 08/14/06 |  | 10.10         |  |              
|               |  |                                                                                                                                                                                     |  |                   | 
|10.11          |  | Form of Subscription Agreement for the purchase of common stock of Chelsea Therapeutics International, Ltd. dated March 19, 2007 and related form of Warrant, dated March 22, 2007. |  | 8-K               |  | 03/20/07 |  | 10.11         |  |              
|               |  |                                                                                                                                                                                     |  |                   | 
|10.12          |  | Form of Subscription Agreement for the purchase of common stock of Chelsea Therapeutics International, Ltd. dated November 1, 2007.                                                 |  | 8-K               |  | 11/02/07 |  | 10.12         |  |              



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|               |  |                                                                                                                                                           |  |                   |  |          |  |               |  |              
|-------------- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ----------------- |  | -------- |  | ------------- |  | -------------
|Exhibit Number |  | Description of Document                                                                                                                                   |  | Registrants Form |  | Dated    |  | ExhibitNumber |  | FiledHerewith
|21.1           |  | Subsidiaries of Chelsea Therapeutics International, Ltd.                                                                                                  |  | 10-K              |  | 03/12/07 |  | 10.4          |  |              
|               |  |                                                                                                                                                           |  |                   | 
|23.1           |  | Consent of Independent Registered Public Accounting Firm.                                                                                                 |  |                   |  |          |  |               |  | X            
|               |  |                                                                                                                                                           |  |                   | 
|23.2           |  | Consent of Independent Registered Public Accounting Firm.                                                                                                 |  |                   |  |          |  |               |  | X            
|               |  |                                                                                                                                                           |  |                   | 
|31.1           |  | Certification by the Chief Executive Officer pursuant to Section 240.13a-14 or section 240.15d-14 of the Securities and Exchange Act of 1934, as amended. |  |                   |  |          |  |               |  | X            
|               |  |                                                                                                                                                           |  |                   | 
|31.2           |  | Certification by the Chief Financial Officer pursuant to Section 240.13a-14 or section 240.15d-14 of the Securities and Exchange Act of 1934, as amended. |  |                   |  |          |  |               |  | X            
|               |  |                                                                                                                                                           |  |                   | 
|32.1           |  | Certification by the Chief Executive Officer pursuant to 18 U.S.C. 1350 as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.             |  |                   |  |          |  |               |  | X            
|               |  |                                                                                                                                                           |  |                   | 
|32.2           |  | Certification by the Chief Financial Officer pursuant to 18 U.S.C. 1350 as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.             |  |                   |  |          |  |               |  | X            



|* | The registrant received confidential treatment with respect to certain portions of this exhibit. Such portions have been omitted from this exhibit and have been filed separately
with the SEC.
|- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report
to be signed on its behalf by the undersigned, thereunto duly authorized this 3rd day of March 2009.



CHELSEA THERAPEUTICS INTERNATIONAL, LTD.By:

/S/    SIMON
PEDDERSimon Pedder, Ph.D.President and Chief Executive Officer


Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, this report
has been signed below by the following persons on behalf of the Registrant and in the capacities and on the 3rd day of March 2009.



|                                                       |  |                                                                                                      
|------------------------------------------------------ |  | -----------------------------------------------------------------------------------------------------
|Name                                                   |  | Title                                                                                                
|                                                       | 
|/S/    SIMON
PEDDER Simon Pedder, Ph.D.                |  | President, Chief Executive Officer and Director(Principal Executive Officer)                         
|                                                       | 
|/S/    J. NICK
RIEHLE J. Nick Riehle                   |  | Vice President, Administration and ChiefFinancial Officer (Principal Financial andAccounting Officer)
|                                                       | 
|/S/    MICHAEL
WEISER Michael Weiser, M.D., Ph.D.      |  | Director                                                                                             
|                                                       | 
|/S/    KEVAN
CLEMENS Kevan Clemens, Ph.D.              |  | Director                                                                                             
|                                                       | 
|/S/    JOHNSON Y.N.
LAU Johnson Y.N. Lau, M.D.         |  | Director                                                                                             
|                                                       | 
|/S/    NORMAN
HARDMAN Norman Hardman, Ph.D.            |  | Director                                                                                             
|                                                       | 
|/S/    ROGER
STOLL Roger Stoll, Ph.D.                  |  | Director                                                                                             
|                                                       | 
|/S/    WILLIAM
SCHWIETERMAN William Schwieterman, M.D. |  | Director                                                                                             



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Report of Independent Registered Public Accounting Firm

The Board of Directors and Stockholders

Chelsea Therapeutics International,
Ltd. and Subsidiary

We have audited the accompanying consolidated balance sheet of Chelsea Therapeutics International, Ltd and Subsidiary
(a development stage company) as of December 31, 2008, and the related consolidated statements of operations, changes in stockholders equity, and cash flows for the year then ended, and for the period April 3, 2002 (inception)
through December 31, 2008. These financial statements are the responsibility of the Companys management. Our responsibility is to express an opinion on these financial statements based on our audits. The financial statements as
of December 31, 2007, and for the period April 3, 2002 (inception) through December 31, 2007, were audited by other auditors whose report dated March 10, 2008 expressed an unqualified opinion on those statements. The financial
statements for the period April 3, 2002 (inception) through December 31, 2007 include total operating expenses and net loss of $37,144,571 and $34,685,202, respectively. Our opinion on the consolidated statements of operations,
changes in stockholders equity, and cash flows for the period April 3, 2002 (inception) through December 31, 2008, insofar as it relates to amounts for prior periods through December 31, 2007, is based solely on the report of
other auditors.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States).
Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and
disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits
provide a reasonable basis for our opinion.

In our opinion, based on our audit and the report of other auditors, the financial statements
referred to above present fairly, in all material respects, the consolidated financial position of Chelsea Therapeutics International, Ltd. and Subsidiary at December 31, 2008, and the consolidated results of their operations and their cash
flows for the year then ended and the period from April 3, 2002 (inception) through December 31, 2008, in conformity with U.S. generally accepted accounting principles.

The accompanying financial statements have been prepared assuming that Chelsea Therapeutics International, Ltd. and Subsidiary will continue as a going
concern. As more fully described in Note 1, the Company has incurred recurring net losses and negative cash flows from operations. These conditions raise substantial doubt about the Companys ability to continue as a going concern.
Managements plans in regard to these matters also are described in Note 1. The 2008 financial statements do not include any adjustments to reflect the possible future effects on the recoverability and classification of assets or the amounts
and classification of liabilities that may result from the outcome of this uncertainty.

We also have audited, in accordance with the
standards of the Public Company Accounting Oversight Board (United States), Chelsea Therapeutics International, Ltd. and Subsidiarys internal control over financial reporting as of December 31, 2008, based on criteria established in
Internal Control-Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission and our report dated March 3, 2009,expressed an unqualified opinion thereon.



/s/    ERNST & YOUNG LLP


Charlotte, North Carolina

March 3, 2009



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##### Table of Contents

Report of Independent Registered Public Accounting Firm

The Board of Directors and Stockholders

Chelsea Therapeutics International,
Ltd.

We have audited the accompanying consolidated balance sheet of Chelsea Therapeutics International, Ltd. and Subsidiary (A Development
Stage Company) as of December 31, 2007, and the related consolidated statements of operations, changes in stockholders equity and cash flows for each of the two years in the period ended December 31, 2007 and the period from
April 3, 2002 (inception) to December 31, 2007. These consolidated financial statements are the responsibility of the Companys management. Our responsibility is to express an opinion on these consolidated financial statements based
on our audits.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States).
Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and
disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits
provide a reasonable basis for our opinion.

In our opinion, the consolidated financial statements referred to above present fairly, in all
material respects, the financial position of Chelsea Therapeutics International, Ltd. and Subsidiary (A Development Stage Company) as of December 31, 2007, and their results of operations and cash flows for each of the two years in the period
ended December 31, 2007 and the period from April 3, 2002 (inception) to December 31, 2007, in conformity with accounting principles generally accepted in the United States of America.



|                                   
|-----------------------------------
|/s/    J. H. COHN LLP              
|                                   
|Roseland, New Jersey March 10,
2008



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##### Table of Contents

CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

CONSOLIDATED BALANCE SHEETS



|                                                                                                                                     |  |                  |             |   |                  |   |             |  
|------------------------------------------------------------------------------------------------------------------------------------ |  | ---------------- | ----------- | - | ---------------- | - | ----------- | -
|                                                                                                                                     |  | December 31,2008 |             |   | December 31,2007 |  
|Assets                                                                                                                               |  |                  |             |   |                  |   |             |  
|Current assets:                                                                                                                      |  |                  |             |   |                  |   |             |  
|Cash and cash equivalents                                                                                                            |  | $                | 21,532,553  |   |                  | $ | 34,076,217  |  
|Short-term investments, net                                                                                                          |  |                  | 10,305,745  |   |                  |   | 28,638,336  |  
|Prepaid contract research and manufacturing                                                                                          |  |                  | 625,377     |   |                  |   | 299,319     |  
|Other prepaid expenses and other current assets                                                                                      |  |                  | 101,861     |   |                  |   | 93,243      |  
|                                                                                                                                     |  |                  |             |   |                  |   |             |  
|Total current assets                                                                                                                 |  |                  | 32,565,536  |   |                  |   | 63,107,115  |  
|Property and equipment, net                                                                                                          |  |                  | 159,189     |   |                  |   | 42,793      |  
|Long-term investments, net                                                                                                           |  |                  | 11,328,768  |   |                  |   |            |  
|Other assets                                                                                                                         |  |                  | 76,950      |   |                  |   | 13,461      |  
|                                                                                                                                     |  |                  |             |   |                  |   |             |  
|                                                                                                                                     |  | $                | 44,130,443  |   |                  | $ | 63,163,369  |  
|                                                                                                                                     |  |                  |             |   |                  |   |             |  
|Liabilities and Stockholders Equity                                                                                                 |  |                  |             |   |                  |   |             |  
|Current liabilities:                                                                                                                 |  |                  |             |   |                  |   |             |  
|Accounts payable                                                                                                                     |  | $                | 4,304,283   |   |                  | $ | 888,560     |  
|Accrued compensation and related expenses                                                                                            |  |                  | 579,875     |   |                  |   | 567,268     |  
|Accrued contract research and manufacturing                                                                                          |  |                  | 7,029,838   |   |                  |   | 3,540,629   |  
|Other accrued expenses                                                                                                               |  |                  | 391,082     |   |                  |   | 200,333     |  
|                                                                                                                                     |  |                  |             |   |                  |   |             |  
|Total current liabilities                                                                                                            |  |                  | 12,305,078  |   |                  |   | 5,196,790   |  
|Line of credit payable                                                                                                               |  |                  | 7,277,468   |   |                  |   |            |  
|                                                                                                                                     |  |                  |             |   |                  |   |             |  
|Total liabilities                                                                                                                    |  |                  | 19,582,546  |   |                  |   | 5,196,790   |  
|                                                                                                                                     |  |                  |             |   |                  |   |             |  
|                                                                                                                                     |  |                 
|Commitments                                                                                                                          |  |                  |             |   |                  |   |             |  
|Stockholders equity:                                                                                                                |  |                  |             |   |                  |   |             |  
|Preferred stock, $0.0001 par value, 5,000,000 shares authorized, no shares issued and outstanding                                    |  |                  |            |   |                  |   |            |  
|Common stock, $0.0001 par value, 45,000,000 shares authorized, 30,111,479 and 29,917,454 shares issued and outstanding,
respectively |  |                  | 3,011       |   |                  |   | 2,992       |  
|Additional paid-in capital                                                                                                           |  |                  | 94,316,239  |   |                  |   | 92,648,789  |  
|Deficit accumulated during the development stage                                                                                     |  |                  | (69,771,353 | ) |                  |   | (34,685,202 | )
|                                                                                                                                     |  |                  |             |   |                  |   |             |  
|Total stockholders equity                                                                                                           |  |                  | 24,547,897  |   |                  |   | 57,966,579  |  
|                                                                                                                                     |  |                  |             |   |                  |   |             |  
|                                                                                                                                     |  | $                | 44,130,443  |   |                  | $ | 63,163,369  |  
|                                                                                                                                     |  |                  |             |   |                  |   |             |  

See accompanying notes to consolidated financial statements.



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##### Table of Contents

CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

CONSOLIDATED STATEMENTS OF OPERATIONS



|                                                                       |  |                                  |             |   |                                                        |   |             |      |  |   |            |   |  |   |             |  
|---------------------------------------------------------------------- |  | -------------------------------- | ----------- | - | ------------------------------------------------------ | - | ----------- | ---- |  | - | ---------- | - |  | - | ----------- | -
|                                                                       |  | For the years ended December 31, |             |   | Period fromApril 3, 2002(inception) toDecember 31,2008 |  
|                                                                       |  | 2008                             |             |   | 2007                                                   |   |             | 2006 |  |  
|Operating expenses:                                                    |  |                                  |             |   |                                                        |   |             |      |  |   |            |   |  |   |             |  
|Research and development                                               |  | $                                | 27,109,174  |   |                                                        | $ | 12,336,266  |      |  | $ | 6,864,357  |   |  | $ | 53,634,042  |  
|Sales and marketing                                                    |  |                                  | 1,561,223   |   |                                                        |   | 1,294,359   |      |  |   | 642,263    |   |  |   | 4,190,922   |  
|General and administrative                                             |  |                                  | 3,726,915   |   |                                                        |   | 2,874,762   |      |  |   | 2,027,564  |   |  |   | 11,716,920  |  
|                                                                       |  |                                  |             |   |                                                        |   |             |      |  |   |            |   |  |   |             |  
|Total operating expenses                                               |  |                                  | 32,397,312  |   |                                                        |   | 16,505,387  |      |  |   | 9,534,184  |   |  |   | 69,541,884  |  
|                                                                       |  |                                  |             |   |                                                        |   |             |      |  |   |            |   |  |   |             |  
|                                                                       |  |                                  |             |  
|Operating loss                                                         |  |                                  | (32,397,312 | ) |                                                        |   | (16,505,387 | )    |  |   | (9,534,184 | ) |  |   | (69,541,884 | )
|Interest income                                                        |  |                                  | 1,706,568   |   |                                                        |   | 1,423,842   |      |  |   | 862,808    |   |  |   | 4,199,958   |  
|Interest expense                                                       |  |                                  | (4,920      | ) |                                                        |   |            |      |  |   |           |   |  |   | (38,940     | )
|Other expense                                                          |  |                                  | (4,390,487  | ) |                                                        |   |            |      |  |   |           |   |  |   | (4,390,487  | )
|                                                                       |  |                                  |             |   |                                                        |   |             |      |  |   |            |   |  |   |             |  
|Net loss                                                               |  | $                                | (35,086,151 | ) |                                                        | $ | (15,081,545 | )    |  | $ | (8,671,376 | ) |  | $ | (69,771,353 | )
|                                                                       |  |                                  |             |   |                                                        |   |             |      |  |   |            |   |  |   |             |  
|Net loss per basic and diluted share of common stock                   |  | $                                | (1.17       | ) |                                                        | $ | (0.66       | )    |  | $ | (0.46      | ) |  |   |             |  
|                                                                       |  |                                  |             |   |                                                        |   |             |      |  |   |            |   |  |   |             |  
|Weighted average number of basic and diluted common shares outstanding |  |                                  | 30,027,031  |   |                                                        |   | 22,936,780  |      |  |   | 18,780,638 |   |  |   |             |  
|                                                                       |  |                                  |             |   |                                                        |   |             |      |  |   |            |   |  |   |             |  





See accompanying notes to consolidated financial statements.



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##### Table of Contents

CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS EQUITY



|                                                                                                                                    |  |              |  |                          |       |  |                                  |            |   |                                 |   |        |                                              |  |   |                          |   |  |   |             |   |  |   |            |  
|----------------------------------------------------------------------------------------------------------------------------------- |  | ------------ |  | ------------------------ | ----- |  | -------------------------------- | ---------- | - | ------------------------------- | - | ------ | -------------------------------------------- |  | - | ------------------------ | - |  | - | ----------- | - |  | - | ---------- | -
|                                                                                                                                    |  |              |  | AdditionalPaid-InCapital |       |  | UnpaidSubscriptionon commonstock |            |   | Deferredstock-basedcompensation |   |        | Deficitaccumulatedduring thedevelopmentstage |  |   | Totalstockholdersequity |  
|                                                                                                                                    |  | Common stock |  |                          |       |  |                                 
|                                                                                                                                    |  | Shares       |  | Amount                   |       |  |                                  |            |  
|Issuance of common stock to founders in April 2002                                                                                  |  | 5,428,217    |  | $                        | 542   |  | $                                | 4,083      |   |                                 | $ | (4,625 | )                                            |  | $ |                         |   |  | $ |            |   |  | $ |           |  
|                                                                                                                                    |  |              |  |                          |       |  |                                  |            |   |                                 |   |        |                                              |  |   |                          |   |  |   |             |   |  |   |            |  
|Balance at December 31, 2003                                                                                                        |  | 5,428,217    |  | $                        | 542   |  | $                                | 4,083      |   |                                 | $ | (4,625 | )                                            |  | $ |                         |   |  | $ |            |   |  | $ |           |  
|Common stock issued in March 2004, at approximately $0.0009 per share, for license fee                                              |  | 471,816      |  |                          | 47    |  |                                  | 355        |   |                                 |   |       |                                              |  |   |                         |   |  |   |            |   |  |   | 402        |  
|Sale and issuance of common stock in April 2004, at approximately $0.0009 per share to chief executive                              |  | 478,330      |  |                          | 48    |  |                                  | 360        |   |                                 |   |       |                                              |  |   |                         |   |  |   |            |   |  |   | 408        |  
|Receipt of cash for stock subscription receivable                                                                                   |  |             |  |                          |      |  |                                  |           |   |                                 |   | 4,625  |                                              |  |   |                         |   |  |   |            |   |  |   | 4,625      |  
|Sale and issuance of common stock with detachable warrants in December 2004 at approximately $2.45 per share, net of issuance
costs |  | 5,532,994    |  |                          | 554   |  |                                  | 13,550,255 |   |                                 |   |       |                                              |  |   |                         |   |  |   |            |   |  |   | 13,550,809 |  
|Deferred stock-based compensation                                                                                                   |  |             |  |                          |      |  |                                  | 33,525     |   |                                 |   |       |                                              |  |   | (33,525                  | ) |  |   |            |   |  |   |           |  
|Amortization of deferred stock- based compensation                                                                                  |  |             |  |                          |      |  |                                  |           |   |                                 |   |       |                                              |  |   | 1,529                    |   |  |   |            |   |  |   | 1,529      |  
|Net loss                                                                                                                            |  |             |  |                          |      |  |                                  |           |   |                                 |   |       |                                              |  |   |                         |   |  |   | (3,016,559  | ) |  |   | (3,016,559 | )
|                                                                                                                                    |  |              |  |                          |       |  |                                  |            |   |                                 |   |        |                                              |  |   |                          |   |  |   |             |   |  |   |            |  
|Balance at December 31, 2004                                                                                                        |  | 11,911,357   |  | $                        | 1,191 |  | $                                | 13,588,578 |   |                                 | $ |       |                                              |  | $ | (31,996                  | ) |  | $ | (3,016,559  | ) |  | $ | 10,541,214 |  
|Recapitalization of the Company (See Note 1)                                                                                        |  | 457,168      |  |                          | 46    |  |                                  | (400,046   | ) |                                 |   |       |                                              |  |   |                         |   |  |   |            |   |  |   | (400,000   | )
|Employee stock options exercised                                                                                                    |  | 14,663       |  |                          | 1     |  |                                  | 998        |   |                                 |   |       |                                              |  |   |                          |   |  |   |             |   |  |   | 999        |  
|Adoption of SFAS 123R                                                                                                               |  |             |  |                          |      |  |                                  | (31,996    | ) |                                 |   |       |                                              |  |   | 31,996                   |   |  |   |            |   |  |   |           |  
|Amortization of deferred stock- based compensation                                                                                  |  |             |  |                          |      |  |                                  | 99,319     |   |                                 |   |       |                                              |  |   |                         |   |  |   |            |   |  |   | 99,319     |  
|Variable accounting for stock options granted to third party                                                                        |  |             |  |                          |      |  |                                  | 58,594     |   |                                 |   |       |                                              |  |   |                         |   |  |   |            |   |  |   | 58,594     |  
|Net loss                                                                                                                            |  |             |  |                          |      |  |                                  |           |   |                                 |   |       |                                              |  |   |                         |   |  |   | (7,915,722  | ) |  |   | (7,915,722 | )
|                                                                                                                                    |  |              |  |                          |       |  |                                  |            |   |                                 |   |        |                                              |  |   |                          |   |  |   |             |   |  |   |            |  
|Balance at December 31, 2005                                                                                                        |  | 12,383,188   |  | $                        | 1,238 |  | $                                | 13,315,447 |   |                                 | $ |       |                                              |  | $ |                         |   |  | $ | (10,932,281 | ) |  | $ | 2,384,404  |  
|Sale and issuance of common stock with detachable warrants in February 2006 at approximately $2.77 per share, net of issuance
costs |  | 7,166,666    |  |                          | 717   |  |                                  | 19,854,935 |   |                                 |   |       |                                              |  |   |                         |   |  |   |            |   |  |   | 19,855,652 |  
|Common stock issued in March 2006, at par, pursuant to net-share (cashless) exercise of common stock warrants                       |  | 15,461       |  |                          | 2     |  |                                  | (2         | ) |                                 |   |       |                                              |  |   |                         |   |  |   |            |   |  |   |           |  
|Common stock issued in May 2006, at approximately $4.35 per share, for license fee                                                  |  | 63,131       |  |                          | 6     |  |                                  | 274,615    |   |                                 |   |       |                                              |  |   |                         |   |  |   |            |   |  |   | 274,621    |  
|Employee stock options exercised                                                                                                    |  | 78,683       |  |                          | 8     |  |                                  | 5,072      |   |                                 |   |       |                                              |  |   |                         |   |  |   |            |   |  |   | 5,080      |  
|Stock-based compensation                                                                                                            |  |             |  |                          |      |  |                                  | 283,983    |   |                                 |   |       |                                              |  |   |                         |   |  |   |            |   |  |   | 283,983    |  
|Variable accounting for stock options granted to third party                                                                        |  |             |  |                          |      |  |                                  | 4,192      |   |                                 |   |       |                                              |  |   |                         |   |  |   |            |   |  |   | 4,192      |  
|Net loss                                                                                                                            |  |             |  |                          |      |  |                                  |           |   |                                 |   |       |                                              |  |   |                         |   |  |   | (8,671,376  | ) |  |   | (8,671,376 | )
|                                                                                                                                    |  |              |  |                          |       |  |                                  |            |   |                                 |   |        |                                              |  |   |                          |   |  |   |             |   |  |   |            |  
|Balance at December 31, 2006                                                                                                        |  | 19,707,129   |  | $                        | 1,971 |  | $                                | 33,738,242 |   |                                 | $ |       |                                              |  | $ |                         |   |  | $ | (19,603,657 | ) |  | $ | 14,136,556 |  

See accompanying notes to consolidated financial statements.



F-5



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##### Table of Contents

CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS EQUITY(Continued)



|                                                                                                                                                                                      |  |              |  |                          |       |  |                                  |            |                                 |  |                                              |   |  |                          |   |  |   |             |   |  |   |             |  
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------ |  | ------------------------ | ----- |  | -------------------------------- | ---------- | ------------------------------- |  | -------------------------------------------- | - |  | ------------------------ | - |  | - | ----------- | - |  | - | ----------- | -
|                                                                                                                                                                                      |  |              |  | AdditionalPaid-InCapital |       |  | UnpaidSubscriptionon commonstock |            | Deferredstock-basedcompensation |  | Deficitaccumulatedduring thedevelopmentstage |   |  | Totalstockholdersequity |  
|                                                                                                                                                                                      |  | Common stock |  |                          |       |  |                                 
|                                                                                                                                                                                      |  | Shares       |  | Amount                   |       |  |                                  |            |                                
|Balance at December 31, 2006                                                                                                                                                          |  | 19,707,129   |  | $                        | 1,971 |  | $                                | 33,738,242 |                                 |  | $                                            |  |  | $                        |  |  | $ | (19,603,657 | ) |  | $ | 14,136,556  |  
|Common stock issued during 2007, at par, pursuant to net-share (cashless) exercises of common stock warrants                                                                          |  | 68,136       |  |                          | 6     |  |                                  | (6         | )                               |  |                                              |  |  |                          |  |  |   |            |   |  |   |            |  
|Fair value of warrants issued in May 2006 in consideration of finders fee at approximately $1.75 per share for which vesting was conditioned
on an even that occurred in January 2007 |  |             |  |                          |      |  |                                  | 433,750    |                                 |  |                                              |  |  |                          |  |  |   |            |   |  |   | 433,750     |  
|Sale and issuance of common stock with detachable warrants in March 2007 at approximately $4.33 per share, net of issuance
costs                                                      |  | 2,648,306    |  |                          | 265   |  |                                  | 11,476,412 |                                 |  |                                              |  |  |                          |  |  |   |            |   |  |   | 11,476,677  |  
|Common stock issued in April 2007, at approximately $5.63 per share, for license fee                                                                                                  |  | 26,643       |  |                          | 3     |  |                                  | 149,997    |                                 |  |                                              |  |  |                          |  |  |   |            |   |  |   | 150,000     |  
|Common stock issued in June 2007, at $4.20 per share, pursuant to exercise of common stock warrants, net of fees                                                                      |  | 60,000       |  |                          | 6     |  |                                  | 246,994    |                                 |  |                                              |  |  |                          |  |  |   |            |   |  |   | 247,000     |  
|Common stock issued in October 2007, at $4.20 per share, pursuant to exercise of common stock warrants                                                                                |  | 1,200        |  |                          |      |  |                                  | 5,040      |                                 |  |                                              |  |  |                          |  |  |   |            |   |  |   | 5,040       |  
|Sale and issuance of common stock in November 2007 at approximately $6.19 per share, net of issuance costs                                                                            |  | 7,388,172    |  |                          | 739   |  |                                  | 45,754,030 |                                 |  |                                              |  |  |                          |  |  |   |            |   |  |   | 45,754,769  |  
|Employee stock options exercised                                                                                                                                                      |  | 17,868       |  |                          | 2     |  |                                  | 15,704     |                                 |  |                                              |  |  |                          |  |  |   |            |   |  |   | 15,706      |  
|Stock-based compensation                                                                                                                                                              |  |             |  |                          |      |  |                                  | 828,626    |                                 |  |                                              |  |  |                          |  |  |   |            |   |  |   | 828,626     |  
|Net loss                                                                                                                                                                              |  |             |  |                          |      |  |                                  |           |                                 |  |                                              |  |  |                          |  |  |   | (15,081,545 | ) |  |   | (15,081,545 | )
|                                                                                                                                                                                      |  |              |  |                          |       |  |                                  |            |                                 |  |                                              |   |  |                          |   |  |   |             |   |  |   |             |  
|Balance at December 31, 2007                                                                                                                                                          |  | 29,917,454   |  | $                        | 2,992 |  | $                                | 92,648,789 |                                 |  | $                                            |  |  | $                        |  |  | $ | (34,685,202 | ) |  | $ | 57,966,579  |  



See accompanying notes to
consolidated financial statements.



F-6



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##### Table of Contents

CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS EQUITY(Continued)



|                                                                                                                                                       |  |              |  |                          |       |  |                                  |            |                                 |  |                                              |   |  |                          |   |  |   |             |   |  |   |             |  
|------------------------------------------------------------------------------------------------------------------------------------------------------ |  | ------------ |  | ------------------------ | ----- |  | -------------------------------- | ---------- | ------------------------------- |  | -------------------------------------------- | - |  | ------------------------ | - |  | - | ----------- | - |  | - | ----------- | -
|                                                                                                                                                       |  |              |  | AdditionalPaid-InCapital |       |  | UnpaidSubscriptionon commonstock |            | Deferredstock-basedcompensation |  | Deficitaccumulatedduring thedevelopmentstage |   |  | Totalstockholdersequity |  
|                                                                                                                                                       |  | Common stock |  |                          |       |  |                                 
|                                                                                                                                                       |  | Shares       |  | Amount                   |       |  |                                  |            |                                
|Balance at December 31, 2007                                                                                                                           |  | 29,917,454   |  | $                        | 2,992 |  | $                                | 92,648,789 |                                 |  | $                                            |  |  | $                        |  |  | $ | (34,685,202 | ) |  | $ | 57,966,579  |  
|Common stock issued during 2008, at par, pursuant to net-share (cashless) exercises of common stock warrants                                           |  | 57,983       |  |                          | 6     |  |                                  | (6         | )                               |  |                                              |  |  |                          |  |  |   |            |   |  |   |            |  
|Common stock issued in 2008, at $4.20 per share, pursuant to exercise of common stock warrants                                                         |  | 11,200       |  |                          | 1     |  |                                  | 47,039     |                                 |  |                                              |  |  |                          |  |  |   |            |   |  |   | 47,040      |  
|Final adjustment to issuance costs accrued in conjunction with the sale and issuance of common stock in November 2007 at approximately $6.19
per share |  |             |  |                          |      |  |                                  | 5,733      |                                 |  |                                              |  |  |                          |  |  |   |            |   |  |   | 5,733       |  
|Common stock issued in April 2008, at approximately $4.90 per share, for license fee                                                                   |  | 30,612       |  |                          | 3     |  |                                  | 149,997    |                                 |  |                                              |  |  |                          |  |  |   |            |   |  |   | 150,000     |  
|Employee stock options exercised                                                                                                                       |  | 94,230       |  |                          | 9     |  |                                  | 58,935     |                                 |  |                                              |  |  |                          |  |  |   |            |   |  |   | 58,944      |  
|Stock-based compensation                                                                                                                               |  |             |  |                          |      |  |                                  | 1,405,752  |                                 |  |                                              |  |  |                          |  |  |   |            |   |  |   | 1,405,752   |  
|Net loss                                                                                                                                               |  |             |  |                          |      |  |                                  |           |                                 |  |                                              |  |  |                          |  |  |   | (35,086,151 | ) |  |   | (35,086,151 | )
|                                                                                                                                                       |  |              |  |                          |       |  |                                  |            |                                 |  |                                              |   |  |                          |   |  |   |             |   |  |   |             |  
|Balance at December 31, 2008                                                                                                                           |  | 30,111,479   |  | $                        | 3,011 |  | $                                | 94,316,239 |                                 |  | $                                            |  |  | $                        |  |  | $ | (69,771,353 | ) |  | $ | 24,547,897  |  
|                                                                                                                                                       |  |              |  |                          |       |  |                                  |            |                                 |  |                                              |   |  |                          |   |  |   |             |   |  |   |             |  





See accompanying notes to consolidated financial statements.



F-7



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##### Table of Contents

CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

CONSOLIDATED STATEMENTS OF CASH FLOWS



|                                                                                                  |  |                                  |             |   |                                                        |   |             |      |  |   |             |   |  |   |             |  
|------------------------------------------------------------------------------------------------- |  | -------------------------------- | ----------- | - | ------------------------------------------------------ | - | ----------- | ---- |  | - | ----------- | - |  | - | ----------- | -
|                                                                                                  |  | For the years ended December 31, |             |   | Period fromApril 3, 2002(inception) toDecember 31,2008 |  
|                                                                                                  |  | 2008                             |             |   | 2007                                                   |   |             | 2006 |  |  
|Operating activities:                                                                             |  |                                  |             |   |                                                        |   |             |      |  |   |             |   |  |   |             |  
|Net loss                                                                                          |  | $                                | (35,086,151 | ) |                                                        | $ | (15,081,545 | )    |  | $ | (8,671,376  | ) |  | $ | (69,771,353 | )
|Adjustments to reconcile net loss to net cash used in operating activities:                       |  |                                  |             |   |                                                        |   |             |      |  |   |             |   |  |   |             |  
|Non-cash stock-based compensation                                                                 |  |                                  | 1,405,752   |   |                                                        |   | 828,626     |      |  |   | 283,983     |   |  |   | 2,619,209   |  
|Non-cash stock-based variable accounting compensation                                             |  |                                  |            |   |                                                        |   |            |      |  |   | 4,192       |   |  |   | 62,786      |  
|Depreciation and amortization                                                                     |  |                                  | 57,164      |   |                                                        |   | 31,022      |      |  |   | 35,389      |   |  |   | 160,473     |  
|Stock issued for license fee                                                                      |  |                                  | 150,000     |   |                                                        |   | 150,000     |      |  |   | 274,621     |   |  |   | 575,023     |  
|Non-cash interest expense                                                                         |  |                                  |            |   |                                                        |   |            |      |  |   |            |   |  |   | 34,020      |  
|Other-than temporary impairment of short-term and long-term investments                           |  |                                  | 4,390,487   |   |                                                        |   |            |      |  |   |            |   |  |   | 4,390,487   |  
|Gain on disposition of fixed assets                                                               |  |                                  | (2,208      | ) |                                                        |   |            |      |  |   |            |   |  |   | (2,208      | )
|Fair value of warrants for finders fee                                                           |  |                                  |            |   |                                                        |   | 433,750     |      |  |   |            |   |  |   | 433,750     |  
|Changes in operating assets and liabilities:                                                      |  |                                  |             |   |                                                        |   |             |      |  |   |             |   |  |   |             |  
|Prepaid expenses and other current assets                                                         |  |                                  | (334,676    | ) |                                                        |   | (175,743    | )    |  |   | (19,891     | ) |  |   | (727,238    | )
|Accounts payable, accrued contract research and manufacturing expenses and other accrued expenses |  |                                  | 7,095,680   |   |                                                        |   | 3,005,486   |      |  |   | 826,690     |   |  |   | 11,725,204  |  
|Accrued compensation and related expenses                                                         |  |                                  | 12,607      |   |                                                        |   | 157,313     |      |  |   | 164,682     |   |  |   | 579,875     |  
|                                                                                                  |  |                                  |             |   |                                                        |   |             |      |  |   |             |   |  |   |             |  
|Net cash used in operating activities                                                             |  |                                  | (22,311,345 | ) |                                                        |   | (10,651,091 | )    |  |   | (7,101,710  | ) |  |   | (49,919,972 | )
|                                                                                                  |  |                                  |             |   |                                                        |   |             |      |  |   |             |   |  |   |             |  
|Investing activities:                                                                             |  |                                  |             |   |                                                        |   |             |      |  |   |             |   |  |   |             |  
|Acquisitions of property and equipment                                                            |  |                                  | (175,028    | ) |                                                        |   | (30,877     | )    |  |   | (35,127     | ) |  |   | (321,132    | )
|Proceeds from sale of property and equipment                                                      |  |                                  | 3,677       |   |                                                        |   |            |      |  |   |            |   |  |   | 3,677       |  
|Redemptions (purchases) of short-term investments, net                                            |  |                                  | 2,613,336   |   |                                                        |   | (15,852,509 | )    |  |   | (12,785,827 | ) |  |   | (26,025,000 | )
|Security deposits                                                                                 |  |                                  | (63,489     | ) |                                                        |   |            |      |  |   |            |   |  |   | (76,950     | )
|                                                                                                  |  |                                  |             |   |                                                        |   |             |      |  |   |             |   |  |   |             |  
|Net cash provided by (used in) investing activities                                               |  |                                  | 2,378,496   |   |                                                        |   | (15,883,386 | )    |  |   | (12,820,954 | ) |  |   | (26,419,405 | )
|                                                                                                  |  |                                  |             |   |                                                        |   |             |      |  |   |             |   |  |   |             |  
|Financing activities:                                                                             |  |                                  |             |   |                                                        |   |             |      |  |   |             |   |  |   |             |  
|Proceeds from borrowings from affiliate                                                           |  |                                  |            |   |                                                        |   |            |      |  |   |            |   |  |   | 1,745,000   |  
|Proceeds from borrowings from line of credit                                                      |  |                                  | 7,277,468   |   |                                                        |   |            |      |  |   |            |   |  |   | 7,277,468   |  
|Proceeds from exercise of stock options                                                           |  |                                  | 58,944      |   |                                                        |   | 15,706      |      |  |   | 5,080       |   |  |   | 80,729      |  
|Proceeds from exercise of common stock warrants                                                   |  |                                  | 47,040      |   |                                                        |   | 252,040     |      |  |   |            |   |  |   | 299,080     |  
|Proceeds from sales of equity securities, net of issuance costs                                   |  |                                  | 5,733       |   |                                                        |   | 57,231,446  |      |  |   | 19,855,652  |   |  |   | 88,865,028  |  
|Recapitalization of the Company                                                                   |  |                                  |            |   |                                                        |   |            |      |  |   |            |   |  |   | (400,000    | )
|Receipt of cash for stock subscription receivable                                                 |  |                                  |            |   |                                                        |   |            |      |  |   |            |   |  |   | 4,625       |  
|                                                                                                  |  |                                  |             |   |                                                        |   |             |      |  |   |             |   |  |   |             |  
|Net cash provided by financing activities                                                         |  |                                  | 7,389,185   |   |                                                        |   | 57,499,192  |      |  |   | 19,860,732  |   |  |   | 97,871,930  |  
|                                                                                                  |  |                                  |             |   |                                                        |   |             |      |  |   |             |   |  |   |             |  
|Net (decrease) increase in cash and cash equivalents                                              |  |                                  | (12,543,664 | ) |                                                        |   | 30,964,715  |      |  |   | (61,932     | ) |  |   | 21,532,553  |  
|Cash and cash equivalents, beginning of year                                                      |  |                                  | 34,076,217  |   |                                                        |   | 3,111,502   |      |  |   | 3,173,434   |   |  |   |            |  
|                                                                                                  |  |                                  |             |   |                                                        |   |             |      |  |   |             |   |  |   |             |  
|Cash and cash equivalents, end of year                                                            |  | $                                | 21,532,553  |   |                                                        | $ | 34,076,217  |      |  | $ | 3,111,502   |   |  | $ | 21,532,553  |  
|                                                                                                  |  |                                  |             |   |                                                        |   |             |      |  |   |             |   |  |   |             |  
|Supplemental disclosure of cash flow information:                                                 |  |                                  |             |   |                                                        |   |             |      |  |   |             |   |  |   |             |  
|Cash paid for interest                                                                            |  | $                                | 4,920       |   |                                                        | $ |            |      |  | $ |            |   |  | $ | 4,920       |  
|                                                                                                  |  |                                  |             |   |                                                        |   |             |      |  |   |             |   |  |   |             |  

See accompanying notes to consolidated financial statements.



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CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

CONSOLIDATED STATEMENTS OF CASH FLOWS

Supplemental disclosure of non-cash investing and financing activities:

During 2002, the Company issued 5,428,217 shares of its common stock for a subscription receivable of $4,625.

During 2004, the Company converted a loan with an affiliate for aggregate principal of $1,745,000 and accrued interest of $34,020 into shares of its
common stock, issuing 677,919 shares, at approximately $2.62 per share in lieu of repayment of this obligation.

In December 2004, in
conjunction with and as compensation for activities related to the December 2004 sale of equity securities, the Company issued warrants to purchase 483,701 shares of its common stock, with a purchase price of approximately $2.88 per share and an
aggregate fair value of $14,400

In conjunction with the merger and recapitalization of the Company dated February 11, 2005, the
Company issued 11,911,357 shares of its common stock in exchange for all of the issued and outstanding shares of Chelsea Therapeutics, Inc. In addition, in conjunction with and as compensation for facilitating the merger, the Company issued warrants
for the purchase of 105,516 shares of its common stock at an exercise price of $2.62 per share and an aggregate fair value of $26,700.

In
February 2006, in conjunction with and as compensation for activities related to the February 2006 sale of equity securities, the Company issued warrants to purchase 716,666 shares of its common stock, with a purchase price of $3.30 per share and an
aggregate fair value of approximately $705,000.

In May 2006, in conjunction with and as compensation for activities related to a licensing
agreement and under a Finders Agreement, the Company issued warrants to purchase 250,000 shares of its common stock, with an exercise price of $4.31 per share. The exercise of these warrants was conditioned on an event that occurred in January
2007 and, accordingly, the Company recorded a charge based on the warrants fair value determined at January 2007 of $433,750.



See accompanying notes to consolidated financial statements.



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##### Table of Contents

CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS

1. The Company, Basis of Presentation and Summary of Significant Accounting Policies

The Company

Chelsea Therapeutics
International, Ltd. (Chelsea Ltd. or the Company) is a specialty pharmaceutical company focused on the acquisition, development and commercialization of innovative pharmaceutical products. The Companys currently
licensed compounds target a variety of prevalent medical conditions; particularly rheumatoid arthritis, psoriasis, cancer, other immunological disorders, neurogenic orthostatic hypotension and other autonomic disorders. The Companys operating
subsidiary, Chelsea Therapeutics, Inc. (Chelsea Inc.), was incorporated in the State of Delaware on April 3, 2002 as Aspen Therapeutics, Inc., with the name changed in July 2004. In February 2005, Chelsea Inc. merged with a
wholly-owned subsidiary of our predecessor company, Ivory Capital Corporation (Ivory), a Colorado public company with no operations (the Merger). The Company reincorporated into the State of Delaware in July 2005, changing
its name to Chelsea Therapeutics International, Ltd.

As a result of the Merger of Ivory and Chelsea Inc. in February 2005, and the
reincorporation in Delaware in July 2005, Chelsea Ltd. is the reporting company and is the 100% owner of Chelsea Inc. The separate existence of Ivory ceased in connection with the Delaware reincorporation in July 2005. Except where the context
provides otherwise, references to the Company and similar terms mean Ivory, Chelsea Ltd. and Chelsea Inc.

Going Concern

The Company has incurred significant net losses and has had negative cash flows from operations during each period from inception
through December 31, 2008 and has a deficit accumulated during the development stage of $69.8 million at December 31, 2008. Management expects operating losses and negative cash flows from operations to continue at least into 2009.

At December 31, 2008, management believes that currently available capital resources will be sufficient to meet operating needs into
the fourth quarter of 2009. This estimate is based on the assumption that the Company will be able to gain liquidity from its investments in auction rate securities that are held with Banc of America Securities and are currently classified as
short-term investments. While this estimate does not rely on additional sources of liquidity, the Company continues to actively pursue such opportunities in anticipation of ongoing liquidity needs. Potential sources of additional liquidity might
include strategic relationships, out-licensing of the Companys products, public or private sales of equity or debt and other sources. Such strategic relationships or out-licensing arrangements might require the Company to relinquish rights to
certain of its technologies, product candidates or products that the Company would otherwise seek to develop or commercialize itself. If adequate funds are not available, the Company may be required to delay, reduce the scope of, or eliminate one or
more of its development programs or curtail operations. Moreover, if the Company does not obtain additional financing or other liquidity by mid-2009, it would expect to delay certain discretionary development activity and certain activities
otherwise planned for the commercialization of droxidopa in the US market.

The accompanying financial statements have been prepared
assuming the Company will continue to operate as a going concern, which contemplates the realization of assets and the settlement of liabilities and commitments in the normal course of business. The consolidated financial statements do not include
any adjustments to reflect the possible future effects on the recoverability and classification of assets or the amounts and classification of liabilities that may result from uncertainty related to the Companys ability to continue as a going
concern.



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##### Table of Contents

CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



Basis of Presentation

Since inception, the Company has focused primarily on organizing and staffing, negotiating in-licensing agreements with partners, acquiring, developing and securing its proprietary technology, participating in
regulatory discussions with the United States Food and Drug Administration (FDA), the European Medicines Agency (EMEA) and other regulatory agencies and undertaking preclinical trials and clinical trials of product
candidates. The Company is a development stage company and has generated no revenue since inception.

The Company has sustained operating
losses since its inception and expects such losses to continue over the next several years. Management plans to continue financing the operations with equity issuances, debt arrangements, strategic alliances or other arrangements of a collaborative
nature. If adequate funds are not available, the Company may be required to delay, reduce the scope of, or eliminate one or more of its research or development programs, delay certain activities, or limit or cease operations and its business,
financial condition and results of operations would be materially harmed

For presentation purposes, the Company has restated all
information contained in this report related to shares authorized, issued and outstanding and related disclosures of weighted average shares and loss per share to reflect the results of the Delaware reincorporation in July 2005 as if the Delaware
reincorporation had occurred at the beginning of each of the periods presented.

Basis of Consolidation

All significant intercompany transactions and balances have been eliminated in consolidation.

Use of Estimates

The preparation of financial
statements in conformity with accounting principles generally accepted in the United States of America requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent
liabilities at the date of the financial statements as well as the reported revenues and expenses during the reporting periods. On an ongoing basis, management evaluates its estimates and judgments. Management bases estimates on its historical
experience and on various other factors that it believes are reasonable under the circumstances, the results of which form the basis for making judgments about the carrying value of assets and liabilities that are not readily apparent from other
sources. Actual results may differ from these estimates under different assumptions or conditions.

Cash and Cash Equivalents

Cash and cash equivalents consist of cash and other highly-liquid investments with maturities of three months or less from the date of purchase.

Short-Term and Long-Term Investments

Investments consist of investments in certain auction rate securities (ARS). ARS are generally long-term debt instruments for which interest rates are reset through a dutch auction process that occurs at pre-determined calendar intervals,
generally each 28 or 35 days. The Company accounts for such investments utilizing Statement of Financial Accounting Standards No. 115 (SFAS 115), Accounting for Certain Investments in Debt and Equity Securities.SFAS 115 requires that
the Company evaluate whether an event or change in circumstances has occurred during the period that may have a significant adverse effect on the fair value of the investment (an



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CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



impairment indicator) at the balance sheet date. If an impairment indicator is present, the Company performs an analysis based on
other-than-temporary impairment factors to determine if a decline in value occurred and whether such decline is temporary or other-than-temporary. If it is determined that the decline in value is other-than-temporary, then an impairment loss would
be recognized in operations and the fair value of such investments would be reflected on the consolidated balance sheet.

Concentration of Credit
Risk

Financial instruments that potentially subject the Company to a significant concentration of credit risk consist primarily of
cash and cash equivalents, short-term investments and long-term investments. The Company maintains deposits in federally insured financial institutions that, under the Temporary Liquidity Guarantee Program, are fully insured by the Federal Deposit
Insurance Commission. The Company also holds investments in Treasury Funds with an average maturity under 90 days. However, management believes the Company is not exposed to significant credit risk for its cash and cash equivalents due to the
financial position of the depository institutions in which those deposits are held and the nature of the investments.

At December 31,
2008, the Company had investments in ARS, classified on the consolidated balance sheet as short-term and long-term investments, with an aggregated par value of approximately $26 million and an estimated aggregate fair value of $19.7 million.
Historically, ARS were priced at par, as per industry convention, based on observed or reported verifiable trades and provided a liquid market for these ARS investments. However, market liquidity issues have virtually shut down most active market
transactions for ARS. The Companys investments in ARS represent interests in collateralized debt obligations supported by pools of student loans, typically over-collateralized and/or insured by the Federal Family Education Loan Program
(FFELP). None of the ARS investments in the Companys portfolio were backed by sub-prime mortgage loans or other collateral with exposure to certain current market conditions. However, liquidity issues experienced in global credit
and capital markets during 2008 have prevented the Company from liquidating its ARS investments as the amount of securities submitted for sale at ARS auctions has exceeded the market demand, though they continue to pay interest according to their
stated terms. Although insufficient demand related to the ARS auctions is expected to continue, the Company anticipates, based on continuing discussions with investment advisors, that liquidity for its securities might possibly be realized through
redemptions by the issuing agencies, increased participation in secondary markets and/or other means. In the event that the Company is unable to sell the investments at or above their carrying value, these securities may not provide a liquid source
of cash or might require the Company to record additional impairment to the asset value.

Fair Value of Financial Instruments

The carrying value of the Companys financial instruments, including cash and cash equivalents and accounts payable approximates fair value given
their highly-liquid and short-term nature.

Effective January 1, 2008, the Company adopted Statement of Financial Accounting Standard
No. 157 (SFAS 157), Fair Value Measurements,for financial assets and liabilities and any other assets and liabilities carried at fair value. This pronouncement defines fair value, establishes a framework for measuring fair
value and expands disclosures about fair value measurements. The Companys adoption of SFAS 157 did not have a material effect on the Companys consolidated financial position or results of operations.

As defined in SFAS 157, fair value is based on the price that would be received to sell an asset or paid to transfer a liability in an orderly
transaction between market participants at the measurement date. In order to



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CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



increase consistency and comparability in fair value measurements, SFAS 157 establishes a fair value hierarchy that prioritizes observable and unobservable
inputs used to measure fair value into three broad levels, which are described below:



| |  |  | Level 1: Quoted prices (unadjusted) in active markets that are accessible at the measurement date for assets or liabilities. The fair value hierarchy gives the
highest priority to Level 1 inputs.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Level 2: Observable prices that are based on inputs not quoted on active markets, but corroborated by market data.
| | - |  | ------------------------------------------------------------------------------------------------------------------



| |  |  | Level 3: Unobservable inputs are used when little or no market data is available. The fair value hierarchy gives the lowest priority to Level 3 inputs.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------

Property and Equipment

Property, which consists of furniture and fixtures, software and equipment, is stated at cost and depreciated or amortized using the straight-line method over the estimated useful lives of the related assets. The
useful life for all classes of assets other than leasehold improvements is three years. The useful life for leasehold improvements is the remaining term of the lease.

Impairment of Long-Lived Assets

The Company reviews long-lived assets, including property and
equipment, for impairment whenever events or changes in business circumstances indicate that the carrying amount of the assets may not be fully recoverable. An impairment loss would be recognized when estimated undiscounted future cash flows
expected to result from the use of the asset and its eventual disposition are less than its carrying amount. The impairment loss, if recognized, would be based on the excess of the carrying value of the impaired asset over its respective fair value.
Impairment, if any, is assessed using undiscounted cash flows. Through December 31, 2008, there has been no such impairment.

Research and
Development

Research and development expenditures are expensed as incurred. The Company often contracts with third parties to
facilitate, coordinate and perform agreed upon research and development activities. To ensure that research and development costs are expensed as incurred, the Company measures expense based on work performed for the underlying contract,
typically utilizing a percentage-of-completion approach, and records prepaid assets or accrues expenses on a monthly basis for such activities based on the measurement of liability from expense recognition and the receipt of invoices.

These contracts typically call for the payment of fees for services at the initiation of the contract and/or upon the achievement of certain
milestones. In the event that the Company prepays fees for future milestones, it records the prepayment as a prepaid asset and amortizes the asset into research and development expense over the period of time the contracted research and
development services are performed. Most fees are incurred throughout the contract period and are expensed based on their percentage of completion at a particular date.

These contracts generally include pass through fees. Pass through fees include, but are not limited to, regulatory expenses, investigator fees,
travel costs, and other miscellaneous costs including shipping and printing fees. Because these fees are incurred at various times during the contract term and they are used throughout the contract term, the Company records an estimated monthly
expense allocation to recognize the fees during the contract period. Fees incurred to set up the clinical trial are expensed during the setup period.



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CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



Costs related to the acquisition of technology rights and patents for which development work is still
in process are expensed as incurred and considered a component of research and development costs.

Loss per Share

Basic net loss per common share is calculated by dividing net loss by the weighted-average number of common shares outstanding for the period, without
consideration for potentially dilutive securities. For the periods presented, basic and diluted net loss per common share are identical as potentially dilutive securities from stock options and stock warrants would have an antidilutive effect since
the Company incurred a net loss. The number of shares of common stock potentially issuable at December 31, 2008, 2007 and 2006 upon exercise or conversion that were not included in the computations of net loss per share were 7,055,089,
6,572,308 and 5,307,980, respectively.

Income Taxes

In accordance with Statement of Financial Accounting Standards No. 109, Accounting for Income Taxes(SFAS 109), a deferred tax asset or liability is determined based on the difference between the financial
statement and the tax bases of assets and liabilities as measured by the enacted tax rates, which will be in effect when these differences reverse. The Company provides a valuation allowance against net deferred tax assets unless, based upon the
available evidence, it is more likely than not that the deferred tax assets will be realized.

FASB Interpretation No. 48,
Accounting for Uncertainty in Income Taxes(FIN 48) clarifies the criteria for recognizing tax benefits related to uncertain tax positions under SFAS 109 and requires additional financial statement disclosure. FIN 48 requires that
the Company recognize, in its consolidated financial statements, the impact of a tax position if that position is more likely than not to be sustained upon examination, based on the technical merits of the position. FIN 48 also requires explicit
disclosure about the Companys uncertainties related to the income tax position, including a detailed roll-forward of tax benefits taken that do qualify for financial statement recognition.

Stock-Based Compensation

The Company accounts
for its stock options utilizing Statement of Financial Accounting Standards No. 123(R) (SFAS 123R), Share-based Payment. SFAS 123R requires the measurement and recognition of compensation expense for all share-based payment
awards made to employees and non-employee directors based on estimated fair values determined using an option-pricing model. The value of the portion of the award that is ultimately expected to vest is recognized as expense over the requisite
service periods in the Companys statements of operations. Prior to the adoption of SFAS 123R, on February 11, 2005, the date of the Merger (see Note 1), the Company accounted for stock options issued to employees and non-employee
directors under Statement of Financial Accounting Standards No. 123 (SFAS 123), Accounting for Stock-based Compensation.

The Company adopted SFAS 123R using the modified prospective application to all grants made after February 11, 2005. The adoption of SFAS 123R had no effect on the financial results of the Company from the application of the original
provisions of SFAS 123.

The fair value of each option award made to employees and directors during the years ended December 31, 2008,
2007 and 2006 was estimated on the date of grant using the Black-Scholes closed-form option valuation model utilizing the assumptions noted in the following table. To determine the risk-free interest rate, the



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CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



Company utilized the U.S. Treasury yield curve in effect at the time of grant with a term consistent with the expected term of the Companys awards. The
Company estimated the expected life of the options granted based on anticipated exercises in future periods assuming the success of its business model as currently forecasted. The expected dividends reflect the Companys current and expected
future policy for dividends on its common stock. To determine the expected stock price volatility for stock options, the Company examined historical volatilities for industry peers closely related to the current status of its business, but with
sufficient trading history to be able to determine volatility. Utilizing a weighted average calculation to account for the limited price history of the Companys stock, an analysis of the historical volatility of its stock price in combination
with the historical volatility of the industry peers selected was used to determine an appropriate volatility factor. The Company plans to continue to analyze the expected stock price volatility and expected term assumption at each grant date as
more historical data for its common stock becomes available. Given the limited service period for current employees and the senior nature of the roles for those employees, the Company estimated that it would experience no forfeitures or that the
rate of forfeiture would be immaterial to the recognition of compensation expense for those options currently outstanding. Prior to February 11, 2005, under the provisions of SFAS 123, the Company utilized the minimum value method and assumed
no volatility in determining the fair value of options granted. Due to the limited amount of historical data available to us, particularly with respect to stock-price volatility, employee exercise patterns and forfeitures, actual results could
differ from our assumptions.



|                         |  |                                  |  |                |  |               
|------------------------ |  | -------------------------------- |  | -------------- |  | --------------
|                         |  | For the years ended December 31,
|                         |  | 2008                             |  | 2007           |  | 2006          
|Risk-free interest rate  |  | 2.52% to 3.73%                   |  | 4.24% to 4.95% |  | 4.31% to 5.12%
|Expected life of options |  | 5 years                          |  | 5 years        |  | 5 years       
|Expected dividend yield  |  | 0%                               |  | 0%             |  | 0%            
|Expected volatility      |  | 63.55% to 65.93%                 |  | 66.01%         |  | 37.66%        
|Forfeitures              |  | 0%                               |  | 0%             |  | 0%            

The Company recorded compensation expense of $1,405,752, $828,626 and $283,983 for the years ended
December 31, 2008, 2007 and 2006, respectively, in conjunction with option grants made to employees and non-employee directors. As of December 31, 2008, the Company had total unrecognized compensation expense related to options granted to
employees and non-employee directors of approximately $3.5 million, which will be recognized over a remaining average period of 2.5 years. The expected future amortization expense for unrecognized compensation expense for stock option grants to
employees and non-employee directors at December 31, 2008 is as follows:



|                              |  |   |          
|----------------------------- |  | - | ---------
|Year ending December 31, 2009 |  | $ | 1,425,838
|Year ending December 31, 2010 |  |   | 1,247,425
|Year ending December 31, 2011 |  |   | 748,090  
|Year ending December 31, 2012 |  |   | 114,874  
|                              |  |   |          
|                              |  | $ | 3,536,227
|                              |  |   |          

Options granted to consultants, advisors or other independent contractors that provide services to
the Company are accounted for under the provisions of SFAS 123R and Emerging Issues Task Force Issue No. 96-18 (EITF 96-18), Accounting for Equity Instruments that are Issued to Other than Employees for Acquiring, or in
Conjunction with Selling, Goods or Services.To date, option awards to consultants, advisors or other independent contractors have been granted with an exercise price equal to the market price of the Companys stock at the date of the
grant; have 10-year contractual terms; and vest dependent upon the completion of performance commitments. As such, the value of stock options is measured at the then-current market value as of



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CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



financial reporting dates and compensation cost is recognized for the net change in the fair value of the options for the reporting period, until such
performance commitments are met. Once each commitment is met, the options that vest in association with that commitment are adjusted, for the last-time, to the then-current fair value and compensation cost is recognized accordingly (see Note 7).

In determining the fair value of options granted to consultants, advisors and other independent contractors, the Company uses the
Black-Scholes closed-form option valuation model in a manner consistent with its use in determining the fair value of options granted to employees and directors. However, the expected life of the options is based on the contractual lives as defined
in agreements with the third parties. No such grants were made during 2006, 2007 or 2008.

Recent Accounting Pronouncements

In December 2007, the Financial Accounting Standards Board (FASB) affirmed the conclusions of the Emerging Issues Task Force (EITF) on EITF Issue 07-1,
Accounting for Collaborative Arrangements(EITF 07-1). EITF 07-1 requires collaborators to present the results of activities, for which they act as the principal, on a gross basis and report any payments received from or
made to other collaborators based on other applicable accounting principles generally accepted in the United States (GAAP) or, in the absence of GAAP, based on analogy to authoritative accounting literature or a reasonable, rational and consistently
applied accounting policy election. Further, EITF 07-1 clarified that the determination of whether transactions within a collaborative arrangement are part of a vendor-customer relationship subject to EITF 01-9 Accounting for
Consideration Given by a Vendor to a Customer (Including a Reseller of the Vendors Products). EITF 07-1 is effective for fiscal years beginning after December 15, 2008 and became effective for the Company on
January 1, 2009. The Company currently believes that the adoption of EITF 07-1 will have no material impact on its consolidated financial position or results of operations.

In December 2007, the FASB issued Financial Accounting Standard No. 141 (revised 2007), Business Combinations (SFAS 141R). SFAS
141R establishes principles and requirements for how an acquirer recognizes and measures in its financial statements the identifiable assets acquired, the liabilities assumed, any non-controlling interest in the acquiree and the goodwill acquired.
SFAS 141R also establishes disclosure requirements to enable the evaluation of the nature and financial effects of the business combination. SFAS 141R is effective for financial statements issued for fiscal years beginning after December 15,
2008 and became effective for the Company on January 1, 2009. The Company currently believes that the adoption of SFAS 141R will have no material impact on its consolidated financial position or results of operations.

In December 2007, FASB issued Financial Accounting Standard No. 160, Noncontrolling Interests in Consolidated Financial Statementsan
amendment of ARB No. 51 (SFAS 160). The objective of SFAS 160 is to improve the relevance, comparability, and transparency of the financial information that a reporting entity provides in its consolidated financial statements. SFAS
160 amends ARB No. 51 to establish accounting and reporting standards for the non-controlling interest in a subsidiary and for the deconsolidation of a subsidiary. SFAS 160 also changes the way the consolidated income statement is presented,
establishes a single method of accounting for changes in a parents ownership interest in a subsidiary that do not result in deconsolidation, requires that a parent recognize a gain or loss in net income when a subsidiary is deconsolidated and
expanded disclosures in the consolidated financial statements that clearly identify and distinguish between the interests of the parents owners and the interest of the non-controlling owners of a subsidiary. SFAS 160 is effective for financial
statements issued for the fiscal years beginning on or after December 15, 2008 and became effective for the Company on January 1, 2009. The Company currently believes that the adoption of SFAS 141R will have no material impact on its
consolidated financial position or results of operations.



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CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



In June 2007, the FASB affirmed the conclusions of the EITF with respect to EITF Issue 07-3
Accounting for Advance Payments for Goods or Services to be Used in Future Research and Development Activities(EITF 07-3). EITF 07-3 concluded that non-refundable advance payments for future research and development
activities pursuant to an executory contractual arrangement should be capitalized until the goods have been delivered or the related services performed. EITF 07-3 is effective for fiscal years beginning after December 15, 2008 and became
effective for the Company on January 1, 2009. The Company currently believes that the adoption of EITF 07-3 will have no material impact on its consolidated financial position or results of operations.

2. Auction Rate Securities

The Companys
investments at December 31, 2008 included student-loan backed auction rate securities (ARS) with an aggregate par value of approximately $26.0 million. The Company had historically invested in these securities for short periods of time as part
of its cash management program. These investments are accounted for in accordance with SFAS 115. ARS with an aggregate par value of approximately $14.4 million were classified as available-for-sale at December 31, 2008 as the Company does not
intend, nor has the ability, to hold the ARS to maturity and did not purchase them for the purpose of selling them in the short-term to realize profit on short-term differences in price. Available-for-sale securities are carried at estimated fair
value, based on available information and have been classified as short-term investments. ARS with an aggregate par value of approximately $11.6 million were classified as trading securities based on the terms of a settlement agreement reached
during 2008. Trading securities are carried at estimated fair value, based on available information, and have been classified as long-term investments based on the terms of the settlement agreement.

The Companys ARS investments represent interests in collateralized debt obligations supported by pools of student loans and none are collateralized
by mortgage, credit card or insurance securitizations. All but approximately $4.4 million of the par value of the Companys investments in ARS were AAA/Aaa rated, fully backed by the FFELP and/or over-collateralized. Of the remaining $4.4
million of investments at par value, all were collateralized at 100% or greater and, consistent with the Companys investment policy, $0.75 million carried an A rating, $1.15 million carried an Aa3/AAA rating and the remainder carried AAA/Aaa
ratings. During 2008, the Company reviewed information related to the credit downgrade, as announced by Moodys, of an insurer on one of its investments with a par value of $1.15 million and the resulting downgrade of that investment from AAA
to Aa3. However, the Company had already taken into account the publicized weaknesses of that insurer before such announcement was made. The Company has not been notified of any modification to the credit ratings of the underlying issuing agencies
for any of its investments.

In early 2008, with the liquidity issues in the global credit and capital markets, the Company was informed
that there was insufficient demand at auction for its ARS investments. As a result, auctions for these securities began to fail and by March 2008, all normal market activity had essentially ceased. The securities are currently not liquid and the
interest rates have been reset to predetermined rates per the terms of the investments.

On December 31, 2007, the Company held
investments in ARS of approximately $28.6 million. During the year ended December 31, 2008, the Company received proceeds of approximately $2.6 million from redemptions at par. The estimated fair value of the Companys ARS investments,
classified as available-for-sale, as of December 31, 2008 was approximately $10.3 million, which reflects an other-than-temporary impairment of approximately $4.1 million to the par value of $14.4 million. Taking into consideration the
complexities of the market and the valuation factors as set forth in the guidelines of SFAS 157, the Company engaged the services of a third party valuation expert to assist in and provide data used in establishing estimated fair values for those
ARS classified as available-for-sale at December 31, 2008. Given the Companys inability to hold these securities indefinitely and its preference to liquidate or otherwise leverage these holdings in the very near term, the



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CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



Company recorded an other-than-temporary impairment loss in the quarter ended December 31, 2008 of approximately $1.7 million and an
other-than-temporary impairment loss for the year ended December 31, 2008 of approximately $4.1 million related to these securities.

The estimated fair value of the Companys ARS investments, classified as trading securities, as of December 31, 2008 was approximately $9.4 million, which reflects an adjustment of approximately $2.2 million to the par value of
$11.6 million. During the fourth quarter of 2008, the Company finalized the details of its settlement agreement related to those ARS held at UBS AG. Classified as an institutional investor for purposes of the settlement agreement, in
November 2008, the Company accepted the terms of the settlement agreement for ARS Rights (the ARS Rights) for the illiquid ARS holdings maintained at UBS as of February 13, 2008. The ARS Rights provide the Company with the ability
to sell the ARS, along with the ARS Rights, to UBS at the par value of the ARS no earlier than June 30, 2010 and expire on July 2, 2012. The ARS Rights grant UBS the sole discretion and right to sell or otherwise dispose of ARS at any time
up until June 30, 2010, so long as the holder receives a payment of par upon any sale or disposition. The ARS Rights are not transferable, not tradable and will not be quoted or listed on any securities exchange or any other trading
network.

UBS also agreed that an affiliate would provide the Company with a no net-cost line of credit for up to a portion of the market
value (as determined by UBS) of its ARS holdings. Concurrently, the Company finalized and submitted documents to UBS to initiate the line of credit account and received notification that funds were available under the account in early December 2008.
The Company then requested and, in December 2008, received a wire transfer of approximately $7.3 million and recorded a corresponding long-term liability. Subsequently, in March 2009, the line of credit was amended to provide the Company with a
credit line of up to $11.575 million, including the $7.3 million outstanding at December 31, 2008, with its UBS ARS investments remaining pledged as collateral. Though the loan is payable on demand, if the UBS affiliate should exercise its
right to demand repayment of any portion of the loan prior to the date the Company can exercise its ARS Rights, UBS and its affiliates would be required to arrange for alternative financing on terms and conditions substantially the same as those
contained in the line of credit agreement. If alternative financing cannot be established, then UBS AG, or one of its affiliates, will purchase the Companys pledged UBS ARS at par. As a result, the loan and any alternative financing
will not be payable by the Company prior to the time that it is able to exercise its UBS ARS Rights in accordance with its agreement with UBS. The Company expects to repay the line of credit with the proceeds from the exercise of those ARS
Rights. Proceeds of any sales of the Companys UBS ARS will first be applied to repayment of the line of credit with the balance, if any, deposited into its account.

As the ARS Rights represent a separate freestanding contract between the Company and UBS and are not transferable to a subsequent buyer, the existence of
the put option had no effect upon the determination of fair value for the ARS at December 31, 2008. Recognizing that the ARS Rights act as an economic hedge against any further price movement in those ARS holdings, the Company further elected
the fair value option under SFAS 159 to mitigate volatility in reported earnings due to the relationship between the ARS Rights and the ARS. The Company will adjust the ARS Rights to fair value at each financial statement date with corresponding
changes in fair value reported in earnings. Simultaneously, the Company elected a one-time transfer of the ARS covered under the settlement agreement with UBS from the available-for-sale category to the trading category recognizing the unprecedented
failure of the entire market for ARS. This election allows all future movements in the fair value of the ARSs to be reported in earnings, creating relative accounting symmetry with the ARS Rights until the settlement is realized. Finally, the
Company also reclassified the UBS ARS from short-term investment to long-term investments based on the terms of the settlement agreement.

For those ARS held at UBS under the settlement agreement, the Company believes that normal discounted cash flow modeling continues to have limited validity under current market conditions as the interest rates



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CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



currently associated with the majority of these securities are not truly a factor of value. The ARS, along with those classified as available-for-sale,
continue to pay interest according to their stated terms. However, the application of additional discount factors related to issuer credit ratings, percentage of FFELP or insurance wraps, etc. does make modeling such discounted cash flows feasible
and the Company determined that it should review the valuation for the UBS ARS based on those factors. The Company assigned risk component factors, utilized a liquidity discount of 300 basis points to reflect the continuing weakness in the market
and utilized a five-year life for these assets. In addition, for establishing the fair value of the ARS Rights as of December 31, 2008, the Company reviewed factors including counterparty performance risk and the time value of money utilizing a
discounted cash flow methodology.

Offsetting the impairment charges recorded during the year ended December 31, 2008, the Company
recorded other income and a corresponding long-term asset for the fair value of the ARS Rights obtained in November 2008 of $2.0 million. For 2008, the recording of the gain from the ARS Rights and the recognition of other-than-temporary impairment
losses resulted in a $0.2 million net expense impact on the consolidated statement of operations.

3. Fair Value Measurements

As stated in Note 1. Summary of Significant Accounting Policies and Nature of Operations, on January 1, 2008, the Company adopted the
methods of determining fair value as described in SFAS 157 to value its financial assets and liabilities. In determining fair value, the Company utilizes techniques that optimize the use of observable inputs, when available, and minimize the use of
unobservable inputs to the extent possible. As normal trading activity within public markets for ARS ceased during the quarter ended March 31, 2008 and had not resumed with any regularity at December 31, 2008, there is an absence of
observable market quotes (level 1 inputs). While the Company obtained estimates of recent trading activity in secondary markets for ARS, such markets are not sufficiently active and the resulting data (as specified under SFAS 157) does not qualify
as appropriate level 2 inputs. As such, the Company utilized valuation models for ARS that rely exclusively on unobservable inputs (level 3 inputs) including those that are based on evaluations performed by third party valuation experts as well as
those performed based on percentage of collateralization, counterparty credit quality, risk of default underlying the security, government guarantees or insurance characteristics and overall capital market liquidity.

The Company also took into account the following considerations in its evaluation of fair value at December 31, 2008 and the resulting impairment
charges for the year then ended:



| |  |  | Recent disruptions in the financial markets in general and the additional emphasis on liquidity that has resulted.
| | - |  | ------------------------------------------------------------------------------------------------------------------



| |  |  | A recent valuation analysis for the Companys ARS investments held at Banc of America Securities, prepared by a third party valuation firm, with particular
focus on information and data available from established secondary markets.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | The terms of the settlement between UBS Financial Services, Inc. (UBS) and certain regulatory bodies and the obligations resulting from that settlement
that directly impact the Company. Specifically, the commitment by UBS to provide liquidity to the Company, through a line of credit agreement, for up to 75% of the market value (as determined by UBS) of the securities held at UBS. UBS also
agreed in the settlement to acquire all of those holdings at 100% of par value in June 2010.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



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CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



| |  |  | The Companys ability to continue to hold these ARS considering the terms of the UBS settlement described above and in the absence of similar guarantees with
respect to its holdings at Banc of America Securities.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

The following fair value hierarchy table categorizes information
regarding assets measured at fair value on a recurring basis:



|                           |  |                                                            |        |                                           |   |                                        |  |       |        |  |   |       
|-------------------------- |  | ---------------------------------------------------------- | ------ | ----------------------------------------- | - | -------------------------------------- |  | ----- | ------ |  | - | ------
|                           |  | Assets Measured at Fair Value on a Recurring Basis        
|(in thousands)             |  | Quoted prices inactive marketsfor identicalassets(Level 1) |        | Significantotherobservableinputs(Level 2) |   | Significantunobservableinputs(Level 3) |  | Total
|As of December 31, 2008    |  |                                                            |        |                                           |   |                                        |  |       |        |  |   |       
|Cash and Treasury funds    |  | $                                                          | 21,533 |                                           | $ |                                       |  | $     |       |  | $ | 21,533
|Auction rate securities(1) |  |                                                            |       |                                           |   |                                       |  |       | 10,305 |  |   | 10,305
|Auction rate securities(2) |  |                                                            |       |                                           |   |                                       |  |       | 9,356  |  |   | 9,356 
|ARS Rights (Note 2)        |  |                                                            |       |                                           |   |                                       |  |       | 1,973  |  |   | 1,973 
|                           |  |                                                            |        |                                           |   |                                        |  |       |        |  |   |       
|                           |  | $                                                          | 21,533 |                                           | $ |                                       |  | $     | 21,634 |  | $ | 43,167
|                           |  |                                                            |        |                                           |   |                                        |  |       |        |  |   |       



|(1) | Auction rate securities classified as available-for-sale and as short-term investments. The method used to estimate the fair value of these investments is more fully explained in
Note 2.
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|(2) | The Company transferred a portion of its auction rate securities from available-for-sale to trading in the fourth quarter of 2008. In addition, these securities were reclassified as
long-term investments. The method used to estimate the fair value of these investments is more fully explained in Note 2.
|--- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

The Companys assets that were measured at fair value on a recurring basis using significant Level 3 inputs as of December 31, 2008 consisted of its investments in ARS and its ARS Rights. The following table summarizes the
Companys fair value measurements using significant Level 3 inputs, and changes therein, for the year ended December 31, 2008 (in thousands):



|                                   |  |   |        |  
|---------------------------------- |  | - | ------ | -
|Balance as of December 31, 2007    |  | $ |       |  
|Redemptions at par                 |  |   | (2,613 | )
|Purchases                          |  |   |       |  
|Realized losses(1)                 |  |   | (4,391 | )
|Transfers in and/or out of Level 3 |  |   | 28,638 |  
|                                   |  |   |        |  
|Balance as of December 31, 2008    |  | $ | 21,634 |  
|                                   |  |   |        |  



|(1) | Amount of total losses for the year, net of the gain on ARS Rights, included in other income and expense in the consolidated statement of operations attributable to the change in
fair value related to assets still held as of the reporting date,
|--- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

The valuation of the Companys ARS investment
portfolio is sensitive to market conditions and is based on managements best estimate given the facts available at the time of the estimate. The assumptions utilized in the estimate of fair value are difficult to predict and can change
significantly. Factors that may impact the Companys valuation include potential completion of a transaction in the secondary market by the Company, changes to information provided by the Companys third party valuation expert, ongoing
turmoil in the global financial markets, additional secondary market trading information, the financial position of UBS and the Companys continuing ability to hold these investments with sufficient capital resources to fund operations. The



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##### Table of Contents

CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



results of this analysis indicate that a 1%, or 100 basis point, increase or decrease in the aggregate estimated fair value, as applied to the par value of
such investments, would have increased or decreased the other-than- temporary impairment charge by approximately $0.3 million. Given the uncertainties of selling the securities held with Banc of America Securities on the secondary market, the
realized value could vary from the Companys current valuations by amounts significantly greater than 1%, either favorably or unfavorably.

4.
Property and equipment:

Property and equipment consist of the following:



|                                               |  |              |          |   |      |   |          |  
|---------------------------------------------- |  | ------------ | -------- | - | ---- | - | -------- | -
|                                               |  | December 31, |         
|                                               |  | 2008         |          |   | 2007 |  
|Furniture and fixtures                         |  | $            | 155,366  |   |      | $ | 56,010   |  
|Software                                       |  |              | 19,046   |   |      |   | 19,046   |  
|Leasehold improvements                         |  |              | 24,142   |   |      |   |         |  
|Computer and office equipment                  |  |              | 91,338   |   |      |   | 71,047   |  
|                                               |  |              |          |   |      |   |          |  
|                                               |  |              | 289,892  |   |      |   | 146,103  |  
|Lessaccumulated depreciation and amortization |  |              | (130,703 | ) |      |   | (103,310 | )
|                                               |  |              |          |   |      |   |          |  
|                                               |  | $            | 159,189  |   |      | $ | 42,793   |  
|                                               |  |              |          |   |      |   |          |  

Depreciation and amortization expense was $57,164, $31,022 and $35,389 for the years ended
December 31, 2008, 2007 and 2006, respectively.

5. Common Stock Offerings

On November 8, 2007, the Company raised gross proceeds of approximately $48.9 million through the sale of 7,388,172 shares of its common stock in a
registered direct offering. These shares were offered pursuant to the Companys shelf registration statement as filed with the Securities and Exchange Commission (SEC) under which it may offer shares of its common stock and
preferred stock, various series of debt securities and/or warrants to purchase any of such securities, either individually or in units, in one or more offerings, up to a total dollar amount of $60.0 million. Such registration statement became
effective as of October 11, 2007. In connection with this offering, the Company paid commissions and recorded or accrued other offering-related costs of approximately $3.2 million.

On March 22, 2007, the Company raised gross proceeds of approximately $12.5 million through the sale of 2,648,306 shares of its common stock plus
warrants for the purchase of 794,492 shares of its common stock (the 2007 Placement). The aggregate fair value of these warrants was approximately $1.3 million. The warrants permit the holders to purchase the underlying common shares at
$5.66 each and are exercisable in whole at any time, or in part from time to time, for cash, for five years from the date of issuance. The warrants are redeemable at par value at the Companys option in the event that the volume
weighted-average closing price of the Companys common stock is greater than $12.00 per share for any 20 consecutive trading days provided the Company gives 60 business days written notice to the holders and simultaneously call all
warrants on the same terms. Under the terms of the placement, the Company agreed to and filed a registration statement with the SEC within 30 days of the closing for the shares of common stock sold and the shares of common stock underlying the
warrants and such registration became effective on August 7, 2007. In connection with this offering, the Company paid commissions and other offering-related costs of approximately $1.0 million in cash.



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##### Table of Contents

CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



On February 13, 2006, the Company raised gross proceeds of approximately $21.5 million through
the sale of 7,166,666 shares of its common stock plus warrants for the purchase of 2,149,999 shares of its common stock (the 2006 Placement). The allocated aggregate fair value of these warrants was approximately $1.1 million. The
warrants permit the holders to purchase the underlying common shares, for cash only, at $4.20 each and are exercisable in whole at any time, or in part from time to time, for five years from the date of issuance. The warrants are redeemable at par
value at the Companys option in the event that the Companys volume weighted-average closing bid price of its common stock is greater than $9.00 per share for any 20 consecutive trading days provided that the Company gives 30 business
days written notice to the holders and simultaneously calls all warrants on the same terms. In connection with this offering, the Company paid commissions and other offering-related costs of approximately $1.6 million in cash and issued
warrants to the placement agent for the purchase of 716,666 shares of the Companys common stock with an exercise price of $3.30 per share, or 110% of the price of the shares sold in the offering and an aggregate fair value of approximately
$0.7 million. Under the terms of the 2006 Placement, the Company agreed to and filed a registration statement with the SEC within 30 days of the closing for the shares of common stock sold and the shares of common stock underlying the warrants and
such registration became effective on March 29, 2006.

In December 2004, Chelsea Therapeutics, Inc. raised gross proceeds of
approximately $14.5 million through the sale of 5,532,994 shares of its common stock (the 2004 Placement). The amount raised includes the conversion of a $1.7 million stockholder loan along with accrued interest, for which a total of
677,919 shares of common stock were issued. In connection with this offering, Chelsea Therapeutics, Inc. paid commissions and other offering-related costs of approximately $1.0 million in cash and issued warrants to the placement agent for the
purchase of 483,701 shares of its common stock with an aggregate fair value of approximately $14,000.

6. Commitments

Facility Lease

On March 7, 2008 the
Company entered into a lease for office space in Charlotte, North Carolina near its former office location to serve as its new corporate headquarters. Occupancy occurred on or about May 15, 2008 with monthly payments beginning October 15,
2008 of approximately $19,000. The lease expires on October 15, 2013 and calls for annual rent increases of 3%. In addition, the lease provides an option to rent additional adjacent space. The option remains in effect until November 2009
at a cost of $1,750 per month, but may be terminated sooner at the Companys discretion. A security deposit equal to four months rent or approximately $76,000 was paid upon signing the lease.

The Company leased its former corporate headquarters under an operating lease, as amended, that expired in June 2008. The lease contained no provisions
for renewal periods of any fixed lengths.

Rent expense for the years ended December 31, 2008, 2007 and 2006 was $179,614, $57,960 and
$56,278, respectively.

License Agreements

In March 2004, the Company entered into a License Agreement with Dr. M. Gopal Nair, Ph.D., of the University of South Alabama College of Medicine, for rights to use, produce, distribute and market products
derived from an invention by Dr. Nair, claimed in US Patent # 5,912,251, entitled metabolically inert anti-inflammatory and antitumor antifolates, designated by Chelsea as CH-1504 and related compounds. The license provides the
Company with exclusive, worldwide (excluding India) rights for this portfolio of antifolates that includes CH-1504 and related compounds. The Company made an upfront payment in May 2004 of $150,000



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CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



and anniversary milestone payments as required by the agreement of $100,000 each in March 2006 and 2005. In April 2007, the Company issued 26,643 shares of
its common stock, subject to trading restrictions, at a value of approximately $5.63 per share, in settlement of the $150,000 anniversary milestone payment for 2007. In March 2008, the Company made a milestone payment of $100,000 related to patient
dosing in a Phase 2 study as required by the agreement. In April 2008, the Company issued 30,612 shares of its common stock, subject to trading restrictions, at a value of approximately $4.90 per share, in settlement of the 2008 anniversary
milestone payment of $150,000. The Company is required to make additional payments upon the achievement of specific development and regulatory approval milestones. The Company is also obligated to pay royalties under the agreement until the later of
the expiration of the applicable patent or the applicable last date of market exclusivity after the first commercial sale, on a country-by-country basis. Future potential milestone and anniversary payments total approximately $1,500,000 at
December 31, 2008 and there are no minimum royalties required under the agreement.

In May 2006, the Company entered into an agreement
with Dainippon Sumitomo Pharma Co., Ltd. (DSP) for a worldwide, exclusive, sub-licensable license and rights to certain intellectual property and proprietary information (the DSP Agreement) relating to
L-threo-3,4-dihydroxyphenylserine (L-DOPS or droxidopa) including, but not limited to all information, formulations, materials, data, drawings, sketches, designs, testing and test results, records and regulatory
documentation. As consideration for these rights, the Company paid DSP $100,000 and issued 63,131 shares of its common stock, with a value of approximately $4.35 per share, or $274,621. During 2007, the Company made a milestone payment, related to
obtaining orphan drug status from the FDA, under the DSP Agreement of $250,000. In February 2008, the Company made a milestone payment under the DSP Agreement of $500,000 related to patient dosing in a Phase 3 study. As additional consideration, the
Company agreed to pay DSP and or its designees (1) royalties on the sales should any compound be approved for commercial sale; and (2) milestone payments, payable upon achievement of milestones as defined in the DSP Agreement. At
December 31, 2008, remaining potential future milestone payments, subject to the Companys right to terminate the DSP agreement, totaled $3.25 million.

The amount expended under these agreements and charged to research and development expense was $750,000 during the year ended December 31, 2008, $400,000 during the year ended December 31, 2007, and $474,621
during the year ended December 31, 2006.

Subsequent to execution of the DSP Agreement, the Company and DSP have agreed to initiate,
and the Company has agreed to fund, activities focused on modifying the manufacturing capabilities of DSP in order to expand capacity and comply with regulations and requirements of the United States Food and Drug Administration. Such activities are
currently ongoing and shall continue over a two-year period. Based on work performed by DSP as of December 31, 2008, the Company had paid approximately $0.4 million and had recorded liabilities for an additional $3.0 million of costs.

Development and Commercialization Agreement

Effective May 2006, the Company entered into a development and commercialization agreement (the Development Agreement) with Active Biotech AB (AB) to co-develop and commercialize the I-3D
portfolio of orally active, Dihydroorotate dehydrogenase (DHODH) inhibiting compounds for the treatment of autoimmune diseases and transplant rejection. Under the terms of the Development Agreement, an initial payment of $1.0 million was
made to AB at the time of the Development Agreement with such funds utilized to cover the initial costs of research and development efforts jointly approved by both parties. At December 31, 2006, the Company had expensed the entire $1.0 million
payment and expensed additional costs of $0.3 million.



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CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



During 2007, the Company expensed costs of $0.6 million under the program related to costs of research and development. During 2008, the Company and AB
ceased joint discovery efforts on this portfolio and, accordingly, the Company has recorded no costs related to this program during 2008.

In April 2008, the Company and AB entered into a termination and assignment agreement (the Termination Agreement), whereby AB discontinued its participation in the I-3D co-development program and assigned its entire right, title
and interest in the portfolio to the Company in exchange for royalties on future sales. The Termination Agreement also eliminated the Companys obligation related to payment of potential future development milestones under the Development
Agreement.

Contract Research and Manufacturing Purchase Obligations

The Company often contracts with third parties to facilitate, coordinate and perform agreed upon research and development activities. These contracts
typically call for the payment of fees for services at the initiation of the contract and/or upon the achievement of certain milestones. The Company currently intends to continue its research and manufacturing activities as contracted at
December 31, 2008. However, there can be cancellation fees associated with these contracts that could be punitive in nature. Commitments under research and development programs represent contractual commitments entered into for materials and
services in the normal course of business and totaled approximately $24.5 million at December 31, 2008.

7. Stockholders Equity

Preferred Stock

The
Companys Certificate of Incorporation provides that the Board of Directors of the Company has the authority to issue up to an aggregate of 5,000,000 shares of preferred stock in one or more classes or series and to determine, with respect to
any such class or series, the designations, powers, preferences and rights of such class or series, and the qualifications, limitations and restrictions thereof, including dividend rights, dividend rates, conversion rights, voting rights, terms of
redemption (including sinking fund provisions), redemption prices, liquidation preferences and the number of shares constituting any class or series or the designation of such class or series, without further vote or action by the stockholders.

As of December 31, 2008, no shares of preferred stock were issued and outstanding.

Common Stock

In April 2008, the Company
issued 30,612 shares of its common stock, subject to trading restrictions, at a value of approximately $4.90 per share, as consideration for the $150,000 anniversary milestone payment due under its product license agreement with Dr. M. Gopal
Nair (see Note 6).

In April 2007, the Company issued 26,643 shares of its common stock, subject to trading restrictions, at a value of
approximately $5.63 per share, as consideration for the $150,000 anniversary milestone payment due under its product license agreement with Dr. M. Gopal Nair (see Note 6).

In May 2006, the Company issued 63,131 shares of its common stock as consideration for a product license agreement with DSP (see Note 6), with a value of
approximately $4.35 per share, or $274,621.

During April 2004, 471,816 common shares were issued as consideration in the product license
agreement (see Note 6) and 478,330 shares were sold to Simon Pedder, the Companys President and Chief Executive



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CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



Officer under the terms of his employment agreement. These shares were valued at what was, at that time, Chelseas common stock estimated aggregate fair
value of $402 and $408, respectively, with such nominal values reflecting an asset-based valuation methodology.

During 2002, the Company
issued 5,428,217 shares of its common stock for a subscription receivable of $4,625.

Warrants

At December 31, 2008 and 2007, the Company had outstanding warrants to purchase 4,180,449 and 4,292,136 shares, respectively, of the Companys
common stock at prices ranging from $2.62 to $5.66 per share.

In March 2007, in conjunction with 2007 Placement (see Note 5), the Company
issued warrants for the purchase of 794,492 shares of its common stock. The aggregate fair value of these warrants was approximately $1.3 million. The warrants permit the holders to purchase the underlying common shares at $5.66 each and are
exercisable in whole at any time, or in part from time to time, for cash, for five years from the date of issuance. The warrants are redeemable at par value at the Companys option in the event that the volume weighted-average closing price of
the Companys common stock is greater than $12.00 per share for any 20 consecutive trading days provided the Company gives 60 business days written notice to the holders and simultaneously call all warrants on the same terms.

In May 2006, in conjunction with and as compensation for activities related the product license agreement with DSP (see Note 6) and under a
Finders Agreement, the Company issued warrants to purchase 250,000 shares of its common stock, with an exercise price of $4.31 per share. The exercise of these warrants was conditioned on an event that did not occur until January 2007. As
such, in January 2007, the Company recorded a charge based on the warrants aggregate fair value at that date of $433,750.

In
February 2006, in conjunction with the 2006 Placement (see Note 5), the Company issued warrants for the purchase of 2,149,999 shares of its common stock. The allocated aggregate fair value of these warrants was approximately $1.1 million. The
warrants permit the holders to purchase the underlying common shares at $4.20 each and are redeemable at the Companys option in the event that the volume weighted average closing bid price of its common stock for any 20 consecutive trading
days is at least $9.00 per share. The Company also issued warrants to its placement agent to purchase 716,666 shares of its common stock with an exercise price of 110% of the purchase price per share based on shares sold in the 2006 Placement, or
$3.30 per share and an aggregate fair value of approximately $705,000.

In February 2005, in conjunction with and as compensation for
facilitating the Merger (see Note 1), the Company issued warrants for the purchase of 105,516 shares of its common stock at an exercise price of approximately $2.62 per share. The aggregate fair value of these warrants was approximately $26,700.

In December 2004, as compensation for fundraising efforts related to the 2004 Placement (see Note 5), the Company issued warrants to
purchase 483,701 shares of its common stock, with a purchase price of 110% of the purchase price per share based on shares sold in the 2004 Placement, or, as converted under terms of the Merger Agreement, approximately $2.89 per share. The aggregate
fair value of these warrants was approximately $14,000.

Exercise of Common Stock Warrants

During 2008, various warrant holders, on various dates, exercised rights to purchase 100,487 shares of the common stock of the Company, with an average
exercise price of approximately $2.91 per share, pursuant to



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CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



cashless exercises whereby the Company, in net share settlements, issued 57,983 shares of its common stock to the warrant holders based on the excess of the
market price over the exercise price on the respective dates of exercise.

During 2008, various warrant holders, on various dates,
exercised rights to purchase 11,200 shares of the common stock of the Company at an exercise price of $4.20 per share pursuant to a cash exercise whereby the Company recorded proceeds of $47,040.

During 2007, various warrant holders, on various dates, exercised rights to purchase 116,596 shares of the common stock of the Company, with an average
exercise price of approximately $2.90 per share, pursuant to cashless exercises whereby the Company, in net share settlements, issued 68,136 shares of its common stock to the warrant holders based on the excess of the market prices over the exercise
prices on the respective dates of exercise.

During 2007, various warrant holders, on various dates, exercised rights to purchase 61,200
shares of the common stock of the Company at an exercise price of $4.20 per share pursuant to a cash exercise whereby the Company recorded cash proceeds, net of expenses, of $252,040.

During 2006, various warrant holders, on various dates, exercised rights to purchase 30,422 shares of the Companys common stock, with an exercise
price of approximately $2.89 per share, pursuant to cashless exercises whereby the Company, in net share settlements, issued 15,461 shares of its common stock to the warrant holders based on the excess of the market prices over the exercise prices
on the respective dates of exercise.

Stock Options

The Company has a stock incentive plan (the Plan) under which incentive stock options for 4,145,000 shares of the Companys common stock may be granted. Grants under the Plan may be made to employees
(including officers), directors, consultants, advisors or other independent contractors who provide services to the Company or its subsidiary.

Options awards to employees and directors are generally granted with an exercise price equal to the market price of the Companys stock at the date of the grant and generally have 10-year contractual terms.

During the years ended December 31, 2008, 2007 and 2006, the Company granted stock options to employees and non-employee directors for the purchase
of 837,500, 665,500 and 668,085 shares of its common stock, respectively. The grants made during the year ended December 31, 2008 had a weighted average exercise price of $6.11 per share, a weighted average grant date fair value of
approximately $3.41 per share and an exercise price greater than the market value at December 31, 2008, resulting in no intrinsic value as of that date. The grants made during the year ended December 31, 2007 had a weighted average
exercise price of $5.72 per share, a weighted average grant date fair value of approximately $3.39 per share and an exercise price greater than the market value at December 31, 2008, resulting in no intrinsic value as of that date. The grants
made during the year ended December 31, 2006 had a weighted average exercise price of $3.61 per share, a weighted average grant date fair value of approximately $1.47 per share and an exercise price greater than the market value at
December 31, 2008, resulting in no intrinsic value as of that date. Each option granted to employees and non-employee directors during 2008, 2007 and 2006 vests as to 25% of the shares on each of the first, second, third and fourth anniversary
of the vesting commencement date. Following the vesting periods, options are exercisable by employees until the earlier of 90 days after the employees termination with the Company or the ten-year anniversary of the initial grant, subject to
adjustment under certain conditions. Following the vesting periods, options are exercisable by non-employee directors until the earlier of 180 days after they cease to be a member of the Board of Directors or the ten-year anniversary of the initial
grant, subject to adjustment under certain conditions.



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##### Table of Contents

CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



In January 2008, the Board of Directors approved a modification for all grants previously made to
Dr. Jason Stein, a former non-employee director who resigned from the Board on February 8, 2008. This modification extended the option exercise term until December 31, 2008. As a result of the modification, the Company recorded
additional compensation expense during 2008 of approximately $11,000.

The Company recorded compensation expense of $1,405,752, $828,626
and $283,983 for the years ended December 31, 2008, 2007 and 2006, respectively, in conjunction with option grants made to employees and non-employee directors. As of December 31, 2008, the Company had total unrecognized compensation
expense related to options granted to employees and non-employee directors of approximately $3.5 million, which will be recognized over a remaining average period of 2.5 years.

In November 2005, the Company granted a stock option to a third-party contractor to purchase 5,000 shares of its common stock at an exercise price of
$3.10 per share. The option vested 25% at each calendar quarter end date from the date of issuance. For the year ended December 31, 2006, based on the fair value of these options, the Company recorded compensation expense of $4,192. At
December 31, 2007, these options were fully vested.

A summary of the Companys stock option activity and related information
since inception is as follows:



|                                 |  |                    |   |  |                  |   |  |                       |     
|-------------------------------- |  | ------------------ | - |  | ---------------- | - |  | --------------------- | ----
|                                 |  | AvailableFor Grant |   |  | Activity/Balance |   |  | Wtd AvgExercise Price
|Establish 2002 Option Plan       |  | 1,085,648          |   |  |                 |   |  |                       |     
|                                 |  |                    |   |  |                  |   |  |                       |     
|Balance at December 31, 2002     |  | 1,085,648          |   |  |                 |   |  |                       |     
|2003 Activity                    |  |                   |   |  |                 |   |  |                       | n/a 
|                                 |  |                    |   |  |                  |   |  |                       |     
|Balance at December 31, 2003     |  | 1,085,648          |   |  |                 |   |  |                       |     
|                                 |  |                    |  
|Cancel 2002 Stock Option Plan    |  | (1,085,648         | ) |  |                 |   |  |                       |     
|Establish 2004 Stock Option Plan |  | 1,085,648          |   |  |                 |   |  |                       |     
|2004 Option grants               |  | (363,835           | ) |  | 363,835          |   |  | $                     | 0.56
|                                 |  |                    |   |  |                  |   |  |                       |     
|Balance at December 31, 2004     |  | 721,813            |   |  | 363,835          |   |  |                       |     
|                                 |  |                    |  
|2005 Plan Amendment              |  | 410,784            |   |  |                 |   |  |                       |     
|2005 Option grants               |  | (761,451           | ) |  | 761,451          |   |  | $                     | 2.66
|2005 Cancellations               |  | 58,683             |   |  | (58,683          | ) |  | $                     | 2.62
|2005 Exercises                   |  |                   |   |  | (14,663          | ) |  | $                     | 0.07
|                                 |  |                    |   |  |                  |   |  |                       |     
|Balance at December 31, 2005     |  | 429,829            |   |  | 1,051,940        |   |  |                       |     
|                                 |  |                    |  
|2006 Plan Amendments             |  | 1,148,568          |   |  |                 |   |  |                       |     
|2006 Option grants               |  | (668,085           | ) |  | 668,085          |   |  | $                     | 3.61
|2006 Cancellations               |  | 8,802              |   |  | (8,802           | ) |  | $                     | 2.62
|2006 Exercises                   |  |                   |   |  | (78,683          | ) |  | $                     | 0.06
|                                 |  |                    |   |  |                  |   |  |                       |     
|Balance at December 31, 2006     |  | 919,114            |   |  | 1,632,540        |   |  |                       |     
|                                 |  |                    |  
|2007 Plan Amendments             |  | 1,500,000          |   |  |                 |   |  |                       |     
|2007 Option grants               |  | (665,500           | ) |  | 665,500          |   |  | $                     | 5.72
|2007 Exercises                   |  |                   |   |  | (17,868          | ) |  | $                     | 0.88
|                                 |  |                    |   |  |                  |   |  |                       |     
|Balance at December 31, 2007     |  | 1,753,614          |   |  | 2,280,172        |   |  |                       |     
|                                 |  |                    |  
|2008 Option grants               |  | (837,500           | ) |  | 837,500          |   |  | $                     | 6.11
|2008 Cancellations               |  | 148,802            |   |  | (148,802         | ) |  | $                     | 4.95
|2008 Exercises                   |  |                   |   |  | (94,230          | ) |  | $                     | 0.63
|                                 |  |                    |   |  |                  |   |  |                       |     
|Balance at December 31, 2008     |  | 1,064,916          |   |  | 2,874,640        |   |  |                       |     
|                                 |  |                    |   |  |                  |   |  |                       |     



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##### Table of Contents

CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



As of December 31, 2008, there were 2,874,640 options outstanding under the Plan with a weighted
average remaining life of 7.6 years, a weighted average grant date fair value of $2.11 per share and an exercise price greater than the market value at December 31, 2008, resulting in no intrinsic value as of that date. Also, options for
1,130,836 shares had vested and were exercisable at December 31, 2008 with a weighted average remaining contractual life of 6.6 years, a weighted average exercise price of $3.08 per share, a weighted average grant date fair value of $1.09 per
share and an exercise price greater than the market value at December 31, 2008, resulting in no intrinsic value as of that date. During the year ended December 31, 2008, options for 94,230 shares were exercised with a weighted average
exercise price of $0.63 per share and an aggregate intrinsic value as of the dates of exercise of approximately $0.4 million. During the year ended December 31, 2007, options for 17,868 shares were exercised with a weighted average exercise
price of $0.88 per share and an aggregate intrinsic value as of the dates of exercise of approximately $79,000. During the year ended December 31, 2006, options for 78,683 shares were exercised with a weighted average exercise price of $0.06
per share and an aggregate intrinsic value as of the dates of exercise of approximately $0.3 million. The weighted average exercise price for all vested and unvested options outstanding as of December 31, 2008, 2007 and 2006 is approximately
$4.38, $3.62 and $2.73 per share, respectively.

Common Stock Reserved for Future Issuance

Common stock reserved for future issuance consists of the following:



|                                                 |  |              |  |           |  |          
|------------------------------------------------ |  | ------------ |  | --------- |  | ---------
|                                                 |  | December 31,
|                                                 |  | 2008         |  | 2007      |  | 2006     
|Common stock warrants outstanding                |  | 4,180,449    |  | 4,292,136 |  | 3,675,440
|Common stock options outstanding                 |  | 2,874,640    |  | 2,280,172 |  | 1,632,540
|Common stock options available for future grants |  | 1,064,916    |  | 1,753,614 |  | 919,114  
|                                                 |  |              |  |           |  |          
|                                                 |  | 8,120,005    |  | 8,325,922 |  | 6,227,094
|                                                 |  |              |  |           |  |          

8. Income Taxes

The Company believes that there are no uncertain tax positions that fail to meet the more likely than not recognition threshold under FIN 48 to be sustained upon examination. As such, a tabular presentation of those
tax benefits taken that do not qualify for recognition is not presented.

From time to time, the Company may be assessed interest or
penalties by its tax jurisdictions, although, historically, there have been no such assessments and the Company believes that any potential future assessments would be minimal and immaterial to the Companys results of operations and financial
position. In the event the Company receives an assessment for interest and/or penalties, it would be classified in the consolidated financial statements as general and administrative expense.

The Company and its subsidiaries file tax returns in the United States and a small number of state jurisdictions. The statute of limitations for
examination of the Companys returns has expired for years prior to 2005. There are no income tax examinations currently in process nor has the Company been subject to examination since inception. The material jurisdictions subject to potential
examination by taxing authorities for open tax years primarily include the United States and North Carolina.



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##### Table of Contents

CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



The components of the deferred tax assets and the valuation allowance are shown below. The state
carryforwards are shown net of federal tax.



|                                                   |  |              |             |   |      |   |             |  
|-------------------------------------------------- |  | ------------ | ----------- | - | ---- | - | ----------- | -
|                                                   |  | December 31, |            
|                                                   |  | 2008         |             |   | 2007 |  
|Deferred tax assets:                               |  |              |             |   |      |   |             |  
|Net operating loss carryforwardFederal            |  | $            | 22,231,224  |   |      | $ | 10,997,542  |  
|Net operating loss carryforwardState              |  |              | 3,007,754   |   |      |   | 1,487,903   |  
|Licensing costs                                    |  |              | 723,835     |   |      |   | 434,334     |  
|Compensation costs and deferred stock compensation |  |              | 1,002,471   |   |      |   | 459,850     |  
|Other temporary differences                        |  |              | (85,039     | ) |      |   | (27,694     | )
|                                                   |  |              |             |   |      |   |             |  
|                                                   |  |              | 26,880,245  |   |      |   | 13,351,935  |  
|Less valuation allowance                           |  |              | (26,880,245 | ) |      |   | (13,351,935 | )
|                                                   |  |              |             |   |      |   |             |  
|                                                   |  | $            |            |   |      | $ |            |  
|                                                   |  |              |             |   |      |   |             |  

The reasons for the difference between actual income tax benefit and the amount computed by
applying the statutory federal income tax rate to the losses before income tax benefit are as follows:



|                                               |  |              |   |  |        |  
|---------------------------------------------- |  | ------------ | - |  | ------ | -
|                                               |  | December 31, |  
|                                               |  | 2008         |   |  | 2007   |  
|Rate reconciliation:                           |  |              |   |  |        |  
|Statutory federal rate                         |  | -34.00       | % |  | -34.00 | %
|State income tax rate (net of federal benefit) |  | -4.60        | % |  | -4.60  | %
|Certain non-deductible expenses                |  | 0.04         | % |  | 0.08   | %
|Effect of increase in valuation allowance      |  | 38.56        | % |  | 38.52  | %
|                                               |  |              |   |  |        |  
|Effective tax rate                             |  | 0.00         | % |  | 0.00   | %
|                                               |  |              |   |  |        |  

Given the Companys history of incurring operating losses, the Companys ability to
realize its deferred tax assets is not considered more likely than not. As a result, a valuation allowance equal to the total deferred tax assets has been established. The valuation allowance as of December 31, 2008 and 2007 was approximately
$26.9 million and $13.4 million, respectively.

At December 31, 2008, the Company had potentially utilizable federal and state net
operating loss carryforwards of approximately $65.4 million. The net operating loss carryforwards expire in various amounts for federal and state tax purposes through 2028 and 2023, respectively.

The utilization of the Companys net operating losses may be subject to a substantial limitation should a change of ownership occur or have
occurred, as defined under Section 382 of the Internal Revenue Code and similar state provisions. Such limitation could result in the expiration of the net operating loss carryforwards before their utilization. Currently, a valuation
allowance equal to the total deferred tax assets has been established. As such, any limitation resulting from the expiration of the net operating loss carryforwards would be immaterial to the Companys financial condition or results of
operations. Prior to any potential utilization, the Company does plan to undertake a detailed study in order to determine any potential §382 limitations as well as any potential impact of §383 limitations on the utilization of research and
development tax credits that may be available to the Company. The Company is unable to fully estimate the impact of any such §382 and §383



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##### Table of Contents

CHELSEA THERAPEUTICS INTERNATIONAL, LTD. AND SUBSIDIARY

(A Development Stage Company)

NOTES
TO CONSOLIDATED FINANCIAL STATEMENTS(Continued)



limitations nor has it undertaken the steps necessary to fully estimate the potential benefits that may be available to it from the utilization of net
operating losses and research and development tax credits in future periods.

9. Savings and Retirement Plan

During 2005, the Company established a savings and retirement plan under Section 401(k) of the Internal Revenue Code that allows eligible employees
to annually contribute a portion of their annual salary to the plan. The Company matches such contributions up to a maximum of 4% of the employees compensation, as defined. For the years ended December 31, 2008, 2007 and 2006, the Company
made contributions of $86,000, $85,333 and $47,695, respectively.

10. Subsequent Events

Grant of Stock Options

In January 2009 the
Company granted options for the purchase of 760,400 shares of its common stock to employees and non-employee directors. These grants, made during the first quarter of 2009, have a weighted average exercise price of $1.71 per share, a weighted
average fair value of $1.11 per share and were granted at an exercise price equal to the closing market value of the Companys stock on the dates of grant.



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