SAT Report

PMN Number: P-12-0414

SAT Date: 6/29/2012

Print Date: 12/6/2012

Related cases:

Health related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 2 3

 Persistence Bioaccum Toxicity Comments

1 12

Exposure Based Review:

Health:

Ecotox: No

Routes of exposure: Health: Dermal Drinking Water Inhalation 

Ecotox: All releases to water

Fate: ;

P2Rec Comments:

Comment: P2REC: SAT: Do not forward: No skin irritation study was submitted 

to support the claim that the PMN substance is less irritating than THFA.

Keywords:

 Keywords: MUTA; ONCO; DEVEL; IRR-S,E; LIVER; KIDNEY; SENS

Summary of Assessment:

 Fate:

Fate Summary: P-12-0414

FATE: 

Liquid with MP < 25 C (E)

log Kow = 1.92 (M) 

S = 12.9 g/L at 25 C (M)
VP = 4.7E-2 torr at 25 C (NOMO5)

BP = 236 C (NOMO5) based on 100 C @ 5.3 mm Hg (M)

H = 8.70E-8 (E)

log Koc = 1.00 (E)

log Fish BCF = 0.93 (E)

log Fish BAF = 0.60 (E) 

POTW removal (%) = 90 via biodeg; OECD 301C(MITI): 28d: 29.7% (BOD), 33.1% (DOC), 

 100% (GC).

Time for complete ultimate aerobic biodeg = wk-mo

Sorption to soils/sediments = low 

PBT Potential: P1B1

*CEB FATE: Migration to ground water = rapid

 Health:

 Health Summary: Moderate absorption from the skin and GI tract, good 

absorption from the lung (analog), expect Michael addition to the acrylate moieties. Concern for 

mutagenicity, oncogenicity, developmental, liver, and kidney toxicity, sensitization, and 

irritation from the acrylate. 

Expect hydrolysis of the ketal in the stomach to yield methyl ethyl ketone. 

There is concern for developmental toxicity based on release of methyl ethyl ketone in the 

stomach. The oral RfD for methyl ethyl ketone is 0.6 mg/kg-day (IRIS) based on an oral 

(drinking water) multigeneration reproductive developmental study in rats for the analog 

2-butanol which caused decreased pup weight at 594 mg/kg-day (LED05 = 639 mg/kg-day). 

Methyl ethyl ketone caused skeletal variations when tested in an inhalation developmental 

toxicity study in mice at 1764 ppm and the RfC for methyl ethyl ketone was set at 5 mg/m3 

(IRIS). The inhalation study was not used to set the oral RfD because deficiencies in absorption 

data precluded using a route to route extrapolation to derive oral doses from existing inhalation 

data for methyl ethyl ketone.

 Test Data: (-) Salmonella with and without activation; (-) E. coli 

with and without activation; rat oral LD0 = 2000 mg/kg

 Ecotox:

Test Organism Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 2.8

daphnid 48-h LC50 7.0

green algal 96-h EC50 1.5

fish _ chronic value 0.020

daphnid _ chronic 

value

0.31

algal _ chronic 

value

0.40

Sewage Sludge 3-h EC50 _
Sewage Sludge _ Chronic 

Value

_

Ecotox Values Comments: Predictions are based on SARs for acrylates; SAR chemical class

= acrylate; liquid (P) with mp unk; MW 200; S = 2.38 g/L at 25 C,

pH 7 (P); log Kow = 2.07 (EPI); effective concentrations based on 100% active ingredients and 

nominal concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

2

SARs acrylates

SAR Class acrylate

Ecotox Category Acrylates/Methacrylates

Ecotox Factors Comments: 

 SAT Chair: L Keifer 564-8916