EXHIBIT 31.1

CERTIFICATION

I, Joseph Oliveto, certify
that:



| | 1. | I have reviewed this Annual Report on Form 10-K/A of Chelsea Therapeutics
    International, Ltd.;
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| | 2. | Based on my knowledge, this report does not contain any untrue
    statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances
    under which such statements were made, not misleading with respect to the period covered by this report;
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| | 3. | Based on my knowledge, the financial statements, and other financial
    information included in this report, fairly present in all material respects the financial condition, results of operations
    and cash flows of the registrant as of, and for, the periods presented in this report;
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| | 4. | The registrant’s other certifying officer and I are responsible
    for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e))
    and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant
    and have:
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| | a. | designed such disclosure controls and procedures, or caused
    such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating
    to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly
    during the period in which this report is being prepared;
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| | b. | designed such internal control over financial reporting, or
    caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance
    regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance
    with generally accepted accounting principles;
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| | c. | evaluated the effectiveness of the registrant’s disclosure
    controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and
    procedures, as of the end of the period covered by this report based on such evaluation; and
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| | d. | disclosed in this report any change in the registrant’s
    internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s
    fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially
    affect, the registrant’s internal control over financial reporting; and
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| | 5. | The registrant’s other certifying officer and I have disclosed,
    based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the
    audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
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| | a. | all significant deficiencies and material weaknesses in the
    design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s
    ability to record, process, summarize and report financial information; and
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| | b. | any fraud, whether or not material, that involves management
    or other employees who have a significant role in the registrant’s internal control over financial reporting.
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|Date: March 14, 2013 | By:                                           | /s/ Joseph Oliveto
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|                     | Joseph Oliveto                               
|                     | Interim President and Chief Executive Officer