# Patent

## Title
Pesticidal compositions and processes related thereto

## Abstract

This document discloses molecules having the following formula (“Formula One”):




and processes associated therewith.

## Background
CROSS REFERENCE TO RELATED APPLICATIONS
This application claims the benefit of U.S. Provisional Patent Application Ser. No. 61/739,025 filed Dec. 19, 2012, the disclosure of which is expressly incorporated herein by reference.


FIELD OF THE DISCLOSURE
The invention disclosed in this document is related to the field of processes to produce molecules that are useful as pesticides (e.g., acaricides, insecticides, molluscicides, and nematicides), such molecules, and processes of using such molecules to control pests.
BACKGROUND OF THE DISCLOSURE
Pests cause millions of human deaths around the world each year. Furthermore, there are more than ten thousand species of pests that cause losses in agriculture. The world-wide agricultural losses amount to billions of U.S. dollars each year.
Termites cause damage to all kinds of private and public structures. The world-wide termite damage losses amount to billions of U.S. dollars each year.
Stored food pests eat and adulterate stored food. The world-wide stored food losses amount to billions of U.S. dollars each year, but more importantly, deprive people of needed food.
There is an acute need for new pesticides. Certain pests are developing resistance to pesticides in current use. Hundreds of pest species are resistant to one or more pesticides. The development of resistance to some of the older pesticides, such as DDT, the carbamates, and the organophosphates, is well known. But resistance has even developed to some of the newer pesticides, for example, imidacloprid.
Therefore, for many reasons, including the above reasons, a need exists for new pesticides.
DEFINITIONS
The examples given in the definitions are generally non-exhaustive and must not be construed as limiting the invention disclosed in this document. It is understood that a substituent should comply with chemical bonding rules and steric compatibility constraints in relation to the particular molecule to which it is attached.
“Alkenyl” means an acyclic, unsaturated (at least one carbon-carbon double bond), branched or unbranched, substituent consisting of carbon and hydrogen, for example, vinyl, allyl, butenyl, pentenyl, and hexenyl.
“Alkenyloxy” means an alkenyl further consisting of a carbon-oxygen single bond, for example, allyloxy, butenyloxy, pentenyloxy, hexenyloxy.
“Alkoxy” means an alkyl further consisting of a carbon-oxygen single bond, for example, methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, and tert-butoxy.
“Alkyl” means an acyclic, saturated, branched or unbranched, substituent consisting of carbon and hydrogen, for example, methyl, ethyl, (C3)alkyl which represents n-propyl and isopropyl), (C4)alkyl which represents n-butyl, sec-butyl, isobutyl, and tert-butyl.
“Alkynyl” means an acyclic, unsaturated (at least one carbon-carbon triple bond), branched or unbranched, substituent consisting of carbon and hydrogen, for example, ethynyl, propargyl, butynyl, and pentynyl.
“Alkynyloxy” means an alkynyl further consisting of a carbon-oxygen single bond, for example, pentynyloxy, hexynyloxy, heptynyloxy, and octynyloxy.
“Aryl” means a cyclic, aromatic substituent consisting of hydrogen and carbon, for example, phenyl, naphthyl, and biphenyl.
“(Cx-Cy)” where the subscripts “x” and “y” are integers such as 1, 2, or 3, means the range of carbon atoms for a substituent—for example, (C1-C4)alkyl means methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, and tert-butyl, each individually.
“Cycloalkenyl” means a monocyclic or polycyclic, unsaturated (at least one carbon-carbon double bond) substituent consisting of carbon and hydrogen, for example, cyclobutenyl, cyclopentenyl, cyclohexenyl, norbornenyl, bicyclo[2.2.2]octenyl, tetrahydronaphthyl, hexahydronaphthyl, and octahydronaphthyl.
“Cycloalkenyloxy” means a cycloalkenyl further consisting of a carbon-oxygen single bond, for example, cyclobutenyloxy, cyclopentenyloxy, norbornenyloxy, and bicyclo[2.2.2]octenyloxy.
“Cycloalkyl” means a monocyclic or polycyclic, saturated substituent consisting of carbon and hydrogen, for example, cyclopropyl, cyclobutyl, cyclopentyl, norbornyl, bicyclo[2.2.2]octyl, and decahydronaphthyl.
“Cycloalkoxy” means a cycloalkyl further consisting of a carbon-oxygen single bond, for example, cyclopropyloxy, cyclobutyloxy, cyclopentyloxy, norbornyloxy, and bicyclo[2.2.2]octyloxy.
“Halo” means fluoro, chloro, bromo, and iodo.
“Haloalkoxy” means an alkoxy further consisting of, from one to the maximum possible number of identical or different, halos, for example, fluoromethoxy, trifluoromethoxy, 2,2-difluoropropoxy, chloromethoxy, trichloromethoxy, 1,1,2,2-tetrafluoroethoxy, and pentafluoroethoxy.
“Haloalkyl” means an alkyl further consisting of, from one to the maximum possible number of, identical or different, halos, for example, fluoromethyl, trifluoromethyl, 2,2-difluoropropyl, chloromethyl, trichloromethyl, and 1,1,2,2-tetrafluoroethyl.
“Heterocyclyl” means a cyclic substituent that may be fully saturated, partially unsaturated, or fully unsaturated, where the cyclic structure contains at least one carbon and at least one heteroatom, where said heteroatom is nitrogen, sulfur, or oxygen. In the case of sulfur, that atom can be in other oxidation states such as a sulfoxide and sulfone. Examples of aromatic heterocyclyls include, but are not limited to, benzofuranyl, benzoisothiazolyl, benzoisoxazolyl, benzoxazolyl, benzothienyl, benzothiazolyl, cinnolinyl, furanyl, imidazolyl, indazolyl, indolyl, isoindolyl, isoquinolinyl, isothiazolyl, isoxazolyl, oxadiazolyl, oxazolinyl, oxazolyl, phthalazinyl, pyrazinyl, pyrazolinyl, pyrazolyl, pyridazinyl, pyridyl, pyrimidinyl, pyrrolyl, quinazolinyl, quinolinyl, quinoxalinyl, tetrazolyl, thiazolinyl, thiazolyl, thienyl, triazinyl, and triazolyl. Examples of fully saturated heterocyclyls include, but are not limited to, piperazinyl, piperidinyl, morpholinyl, pyrrolidinyl, oxetanyl, tetrahydrofuranyl, tetrahydrothienyl and tetrahydropyranyl. Examples of partially unsaturated heterocyclyls include, but are not limited to, 1,2,3,4-tetrahydroquinolinyl, 4,5-dihydro-oxazolyl, 4,5-dihydro-1H-pyrazolyl, 4,5-dihydro-isoxazolyl, and 2,3-dihydro-[1,3,4]-oxadiazolyl.
Additional examples include the following






DETAILED DESCRIPTION OF THE DISCLOSURE
This document discloses molecules having the following formula (“Formula One”):




wherein:

    
    
        (a) R1 is selected from
        
            (1) H, F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, halo(C1-C8)alkyl, (C1-C8)alkoxy, halo(C1-C8)alkoxy, S(C1-C8)alkyl, S(halo(C1-C8)alkyl), S(O)(C1-C8)alkyl, S(O)(halo(C1-C8)alkyl), S(O)2(C1-C8)alkyl, S(O)2(halo(C1-C8)alkyl), N(R14)(R15),
            (2) substituted (C1-C8)alkyl, wherein said substituted (C1-C8)alkyl has one or more substituents selected from CN and NO2,
            (3) substituted halo(C1-C8)alkyl, wherein said substituted halo(C1-C8)alkyl, has one or more substituents selected from CN and NO2,
            (4) substituted (C1-C8)alkoxy, wherein said substituted (C1-C8)alkoxy has one or more substituents selected from CN and NO2, and
            (5) substituted halo(C1-C8)alkoxy, wherein said substituted halo(C1-C8)alkoxy has one or more substituents selected from CN and NO2;
        
        
        (b) R2 is selected from
        
            (1) H, F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, halo(C1-C8)alkyl, (C1-C8)alkoxy, halo(C1-C8)alkoxy, S(C1-C8)alkyl, S(halo(C1-C8)alkyl), S(O)(C1-C8)alkyl, S(O)(halo(C1-C8)alkyl), S(O)2(C1-C8)alkyl, S(O)2(halo(C1-C8)alkyl), N(R14)(R15),
            (2) substituted (C1-C8)alkyl, wherein said substituted (C1-C8)alkyl has one or more substituents selected from CN and NO2,
            (3) substituted halo(C1-C8)alkyl, wherein said substituted halo(C1-C8)alkyl, has one or more substituents selected from CN and NO2,
            (4) substituted (C1-C8)alkoxy, wherein said substituted (C1-C8)alkoxy has one or more substituents selected from CN and NO2, and
            (5) substituted halo(C1-C8)alkoxy, wherein said substituted halo(C1-C8)alkoxy has one or more substituents selected from CN and NO2;
        
        
        (c) R3 is selected from
        
            (1) H, F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, halo(C1-C8)alkyl, (C1-C8)alkoxy, halo(C1-C8)alkoxy, S(C1-C8)alkyl, S(halo(C1-C8)alkyl), S(O)(C1-C8)alkyl, S(O)(halo(C1-C8)alkyl), S(O)2(C1-C8)alkyl, S(O)2(halo(C1-C8)alkyl), N(R14)(R15),
            (2) substituted (C1-C8)alkyl, wherein said substituted (C1-C8)alkyl has one or more substituents selected from CN and NO2,
            (3) substituted halo(C1-C8)alkyl, wherein said substituted halo(C1-C8)alkyl, has one or more substituents selected from CN and NO2,
            (4) substituted (C1-C8)alkoxy, wherein said substituted (C1-C8)alkoxy has one or more substituents selected from CN and NO2, and
            (5) substituted halo(C1-C8)alkoxy, wherein said substituted halo(C1-C8)alkoxy has one or more substituents selected from CN and NO2;
        
        
        (d) R4 is selected from
        
            (1) H, F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, halo(C1-C8)alkyl, (C1-C8)alkoxy, halo(C1-C8)alkoxy, S(C1-C8)alkyl, S(halo(C1-C8)alkyl), S(O)(C1-C8)alkyl, S(O)(halo(C1-C8)alkyl), S(O)2(C1-C8)alkyl, S(O)2(halo(C1-C8)alkyl), N(R14)(R15),
            (2) substituted (C1-C8)alkyl, wherein said substituted (C1-C8)alkyl has one or more substituents selected from CN and NO2,
            (3) substituted halo(C1-C8)alkyl, wherein said substituted halo(C1-C8)alkyl, has one or more substituents selected from CN and NO2,
            (4) substituted (C1-C8)alkoxy, wherein said substituted (C1-C8)alkoxy has one or more substituents selected from CN and NO2, and
            (5) substituted halo(C1-C8)alkoxy, wherein said substituted halo(C1-C8)alkoxy has one or more substituents selected from CN and NO2;
        
        
        (e) R5 is selected from
        
            (1) H, F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, halo(C1-C8)alkyl, (C1-C8)alkoxy, halo(C1-C8)alkoxy, S(C1-C8)alkyl, S(halo(C1-C8)alkyl), S(O)(C1-C8)alkyl, S(O)(halo(C1-C8)alkyl), S(O)2(C1-C8)alkyl, S(O)2(halo(C1-C8)alkyl), N(R14)(R15),
            (2) substituted (C1-C8)alkyl, wherein said substituted (C1-C8)alkyl has one or more substituents selected from CN and NO2,
            (3) substituted halo(C1-C8)alkyl, wherein said substituted halo(C1-C8)alkyl, has one or more substituents selected from CN and NO2,
            (4) substituted (C1-C8)alkoxy, wherein said substituted (C1-C8)alkoxy has one or more substituents selected from CN and NO2, and
            (5) substituted halo(C1-C8)alkoxy, wherein said substituted halo(C1-C8)alkoxy has one or more substituents selected from CN and NO2;
        
        
        (f) R6 is a (C1-C8)haloalkyl;
        (g) R7 is selected from H, F, Cl, Br, I, OH, (C1-C8)alkoxy, and halo(C1-C8)alkoxy;
        (h) R8 is selected from H, (C1-C8)alkyl, halo(C1-C8)alkyl, OR14, and N(R14)(R15);
        (i) R9 is selected from H, F, Cl, Br, I, (C1-C8)alkyl, halo(C1-C8)alkyl, (C1-C8)alkoxy, halo(C1-C8)alkoxy, OR14, and N(R14)(R15);
        (j) R10 is selected from
        
            (1) H, F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, halo(C1-C8)alkyl, (C1-C8)alkoxy, halo(C1-C8)alkoxy, cyclo(C3-C6)alkyl, S(C1-C8)alkyl, S(halo(C1-C8)alkyl), S(O)(C1-C8)alkyl, S(O)(halo(C1-C8)alkyl), S(O)2(C1-C8)alkyl, S(O)2(halo(C1-C8)alkyl), NR14R15, C(═O)H, C(═O)N(R14)(R15), CN(R14)(R15)(═NOH), (C═O)O(C1-C8)alkyl, (C═O)OH, heterocyclyl, (C2-C8)alkenyl, halo(C2-C8)alkenyl, (C2-C8)alkynyl,
            (2) substituted (C1-C8)alkyl, wherein said substituted (C1-C8)alkyl has one or more substituents selected from OH, (C1-C8)alkoxy, S(C1-C8)alkyl, S(O)(C1-C8)alkyl, S(O)2(C1-C8)alkyl, NR14R15, and
            (3) substituted halo(C1-C8)alkyl, wherein said substituted halo(C1-C8)alkyl, has one or more substituents selected from (C1-C8)alkoxy, S(C1-C8)alkyl, S(O)(C1-C8)alkyl, S(O)2(C1-C8)alkyl, and N(R14)(R15);
        
        
        (k) R11 is selected from C(═X5)N(R14)4C1-C8)alkylC(═X5)N(R14)(R15)) wherein each X5 is independently selected from O, or S;
        (l) R12 is selected from (v), H, F, Cl, Br, I, CN, (C1-C8)alkyl, halo(C1-C8)alkyl, (C1-C8)alkoxy, halo(C1-C8)alkoxy, and cyclo(C3-C6)alkyl;
        (m) R13 is selected from (v), H, F, Cl, Br, I, CN, (C1-C8)alkyl, halo(C1-C8)alkyl, (C1-C8)alkoxy, and halo(C1-C8)alkoxy;
        (n) each R14 is independently selected from H, (C1-C8)alkyl, (C2-C8)alkenyl, substituted (C1-C8)alkyl, halo(C1-C8)alkyl, substituted halo(C1-C8)alkyl), (C1-C8)alkoxy, cyclo(C3-C6)alkyl, aryl, substituted-aryl, (C1-C8)alkyl-aryl, (C1-C8)alkyl-(substituted-aryl), O—(C1-C8)alkyl-aryl, O—(C1-C8)alkyl-(substituted-aryl), heterocyclyl, substituted-heterocyclyl, (C1-C8)alkyl-heterocyclyl, (C1-C8)alkyl-(substituted-heterocyclyl), O—(C1-C8)alkyl-heterocyclyl, O—(C1-C8)alkyl-(substituted-heterocyclyl), N(R16)(R17), (C1-C8)alkyl-C(═O)N(R16)(R17), C(═O)(C1-C8)alkyl, C(═O)(halo(C1-C8)alkyl), C(═O)(C3-C6)cycloalkyl, (C1-C8)alkyl-C(═O)O(C1-C8)alkyl, C(═O)H
        
            wherein each said substituted (C1-C8)alkyl has one or more substituents selected from CN, and NO2,
            wherein each said substituted halo(C1-C8)alkyl), has one or more substituents selected from CN, and NO2,
            wherein each said substituted-aryl has one or more substituents selected from F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, halo(C1-C8)alkyl, (C1-C8)alkoxy, halo(C1-C8)alkoxy, S(C1-C8)alkyl, S(halo(C1-C8)alkyl), N((C1-C8)alkyl)2 (wherein each (C1-C8)alkyl is independently selected), and oxo, and
            wherein each said substituted-heterocyclyl has one or more substituents selected from F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, halo(C1-C8)alkyl, (C1-C8)alkoxy, halo(C1-C8)alkoxy, (C3-C6)cycloalkyl S(C1-C8)alkyl, S(halo(C1-C8)alkyl), N((C1-C8)alkyl)2 (wherein each (C1-C8)alkyl is independently selected), heterocyclyl, C(═O)(C1-C8)alkyl, C(═O)O(C1-C8)alkyl, and oxo, (wherein said alkyl, alkoxy, and heterocyclyl, may be further substituted with one or more of F, Cl, Br, I, CN, and NO2);
        
        
        (o) each R15 is independently selected from H, (C1-C8)alkyl, (C2-C8)alkenyl, substituted (C1-C8)alkyl, halo(C1-C8)alkyl, substituted halo(C1-C8)alkyl), (C1-C8)alkoxy, cyclo(C3-C6)alkyl, aryl, substituted-aryl, (C1-C8)alkyl-aryl, (C1-C8)alkyl-(substituted-aryl), O—(C1-C8)alkyl-aryl, O—(C1-C8)alkyl-(substituted-aryl), heterocyclyl, substituted-heterocyclyl, (C1-C8)alkyl-heterocyclyl, (C1-C8)alkyl-(substituted-heterocyclyl), O—(C1-C8)alkyl-heterocyclyl, O—(C1-C8)alkyl-(substituted-heterocyclyl), N(R16)(R17), (C1-C8)alkyl-C(═O)N(R16)(R17), C(═O)(C1-C8)alkyl, C(═O)(halo(C1-C8)alkyl), C(═O)(C3-C6)cycloalkyl, (C1-C8)alkyl-C(═O)O(C1-C8)alkyl, C(═O)H
        
            wherein each said substituted (C1-C8)alkyl has one or more substituents selected from CN, and NO2,
            wherein each said substituted halo(C1-C8)alkyl), has one or more substituents selected from CN, and NO2,
            wherein each said substituted-aryl has one or more substituents selected from F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, halo(C1-C8)alkyl, (C1-C8)alkoxy, halo(C1-C8)alkoxy, S(C1-C8)alkyl, S(halo(C1-C8)alkyl), N((C1-C8)alkyl)2 (wherein each (C1-C8)alkyl is independently selected), and oxo, and
            wherein each said substituted-heterocyclyl has one or more substituents selected from F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, halo(C1-C8)alkyl, (C1-C8)alkoxy, halo(C1-C8)alkoxy, (C3-C6)cycloalkyl S(C1-C8)alkyl, S(halo(C1-C8)alkyl), N((C1-C8)alkyl)2 (wherein each (C1-C8)alkyl is independently selected), heterocyclyl, C(═O)(C1-C8)alkyl, C(═O)O(C1-C8)alkyl, and oxo, (wherein said alkyl, alkoxy, and heterocyclyl, may be further substituted with one or more of F, Cl, Br, I, CN, and NO2);
        
        
        (p) each R16 is independently selected from H, (C1-C8)alkyl, substituted-(C1-C8)alkyl, halo(C1-C8)alkyl, substituted-halo(C1-C8)alkyl, cyclo(C3-C6)alkyl, aryl, substituted-aryl, (C1-C8)alkyl-aryl, (C1-C8)alkyl-(substituted-aryl), O—(C1-C8)alkyl-aryl, O—(C1-C8)alkyl-(substituted-aryl), heterocyclyl, substituted-heterocyclyl, (C1-C8)alkyl-heterocyclyl, (C1-C8)alkyl-(substituted-heterocyclyl), O—(C1-C8)alkyl-heterocyclyl, O—(C1-C8)alkyl-(substituted-heterocyclyl), O—(C1-C8)alkyl
        
            wherein each said substituted (C1-C8)alkyl has one or more substituents selected from CN, and NO2,
            wherein each said substituted halo(C1-C8)alkyl), has one or more substituents selected from CN, and NO2,
            wherein each said substituted-aryl has one or more substituents selected from F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, halo(C1-C8)alkyl, (C1-C8)alkoxy, halo(C1-C8)alkoxy, S(C1-C8)alkyl, S(halo(C1-C8)alkyl), N((C1-C8)alkyl)2 (wherein each (C1-C8)alkyl is independently selected), and oxo, and
            wherein each said substituted-heterocyclyl has one or more substituents selected from F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, halo(C1-C8)alkyl, (C1-C8)alkoxy, halo(C1-C8)alkoxy, S(C1-C8)alkyl, S(halo(C1-C8)alkyl), N((C1-C8)alkyl)2 (wherein each (C1-C8)alkyl is independently selected), and oxo;
        
        
        (q) each R17 is independently selected from H, (C1-C8)alkyl, substituted-(C1-C8)alkyl, halo(C1-C8)alkyl, substituted-halo(C1-C8)alkyl, cyclo(C3-C6)alkyl, aryl, substituted-aryl, (C1-C8)alkyl-aryl, (C1-C8)alkyl-(substituted-aryl), O—(C1-C8)alkyl-aryl, O—(C1-C8)alkyl-(substituted-aryl), heterocyclyl, substituted-heterocyclyl, (C1-C8)alkyl-heterocyclyl, (C1-C8)alkyl-(substituted-heterocyclyl), O—(C1-C8)alkyl-heterocyclyl, O—(C1-C8)alkyl-(substituted-heterocyclyl), O—(C1-C8)alkyl
        
            wherein each said substituted (C1-C8)alkyl has one or more substituents selected from CN, and NO2,
            wherein each said substituted halo(C1-C8)alkyl), has one or more substituents selected from CN, and NO2,
            wherein each said substituted-aryl has one or more substituents selected from F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, halo(C1-C8)alkyl, (C1-C8)alkoxy, halo(C1-C8)alkoxy, S(C1-C8)alkyl, S(halo(C1-C8)alkyl), N((C1-C8)alkyl)2 (wherein each (C1-C8)alkyl is independently selected), and oxo, and
            wherein each said substituted-heterocyclyl has one or more substituents selected from F, Cl, Br, I, CN, NO2, (C1-C8)alkyl, halo(C1-C8)alkyl, (C1-C8)alkoxy, halo(C1-C8)alkoxy, S(C1-C8)alkyl, S(halo(C1-C8)alkyl), N((C1-C8)alkyl)2 (wherein each (C1-C8)alkyl is independently selected), and oxo;
        
        
        (r) X1 is selected from N and CR12;
        (s) X2 is selected from N, CR9, and CR13;
        (t) X3 is selected from N and CR9; and
        (v) R12 and R13 together form a linkage containing 3 to 4 atoms selected from C, N, O, and S, wherein said linkage connects back to the ring to form a 5 to 6 member saturated or unsaturated cyclic ring, wherein said linkage has at least one substituent X4 wherein X4 is selected from R14, N(R14)(R15), N(R14)(C(═O)R14), N(R14)(C(═S)R14), N(R14)(C(═O)N(R14)(R14)), N(R14)(C(═S)N(R14)(R14)), N(R14)(C(═O)N(R14)((C2-C8)alkenyl)), N(R14)(C(═S)N(R14)((C2-C8)alkenyl)), wherein each R14 is independently selected.
    
    


In another embodiment of this invention R1 may be selected from any combination of one or more of the following —H, F, Cl, Br, I, CN, NO2, methyl, ethyl, (C3)alkyl, (C4)alkyl, (C5)alkyl, (C6)alkyl, (C7)alkyl, (C8)alkyl, halomethyl, haloethyl, halo(C3)alkyl, halo(C4)alkyl, halo(C5)alkyl, halo(C6)alkyl, halo(C7)alkyl, halo(C8)alkyl, methoxy, ethoxy, (C3)alkoxy, (C4)alkoxy, (C5)alkoxy, (C6)alkoxy, (C7)alkoxy, (C8)alkoxy, halomethoxy, haloethoxy, halo(C3)alkoxy, halo(C4)alkoxy, halo(C5)alkoxy, halo(C6)alkoxy, halo(C7)alkoxy, and halo(C8)alkoxy.
In another embodiment of this invention R2 may be selected from any combination of one or more of the following —H, F, Cl, Br, I, CN, NO2, methyl, ethyl, (C3)alkyl, (C4)alkyl, (C5)alkyl, (C6)alkyl, (C7)alkyl, (C8)alkyl, halomethyl, haloethyl, halo(C3)alkyl, halo(C4)alkyl, halo(C5)alkyl, halo(C6)alkyl, halo(C7)alkyl, halo(C8)alkyl, methoxy, ethoxy, (C3)alkoxy, (C4)alkoxy, (C5)alkoxy, (C6)alkoxy, (C7)alkoxy, (C8)alkoxy, halomethoxy, haloethoxy, halo(C3)alkoxy, halo(C4)alkoxy, halo(C5)alkoxy, halo(C6)alkoxy, halo(C7)alkoxy, and halo(C8)alkoxy.
In another embodiment of this invention R3 may be selected from any combination of one or more of the following —H, F, Cl, Br, I, CN, NO2, methyl, ethyl, (C3)alkyl, (C4)alkyl, (C5)alkyl, (C6)alkyl, (C7)alkyl, (C8)alkyl, halomethyl, haloethyl, halo(C3)alkyl, halo(C4)alkyl, halo(C5)alkyl, halo(C6)alkyl, halo(C7)alkyl, halo(C8)alkyl, methoxy, ethoxy, (C3)alkoxy, (C4)alkoxy, (C5)alkoxy, (C6)alkoxy, (C7)alkoxy, (C8)alkoxy, halomethoxy, haloethoxy, halo(C3)alkoxy, halo(C4)alkoxy, halo(C5)alkoxy, halo(C6)alkoxy, halo(C7)alkoxy, and halo(C8)alkoxy.
In another embodiment of this invention R4 may be selected from any combination of one or more of the following —H, F, Cl, Br, I, CN, NO2, methyl, ethyl, (C3)alkyl, (C4)alkyl, (C5)alkyl, (C6)alkyl, (C7)alkyl, (C8)alkyl, halomethyl, haloethyl, halo(C3)alkyl, halo(C4)alkyl, halo(C5)alkyl, halo(C6)alkyl, halo(C7)alkyl, halo(C8)alkyl, methoxy, ethoxy, (C3)alkoxy, (C4)alkoxy, (C5)alkoxy, (C6)alkoxy, (C7)alkoxy, (C8)alkoxy, halomethoxy, haloethoxy, halo(C3)alkoxy, halo(C4)alkoxy, halo(C5)alkoxy, halo(C6)alkoxy, halo(C7)alkoxy, and halo(C8)alkoxy.
In another embodiment of this invention R5 may be selected from any combination of one or more of the following —H, F, Cl, Br, I, CN, NO2, methyl, ethyl, (C3)alkyl, (C4)alkyl, (C5)alkyl, (C6)alkyl, (C7)alkyl, (C8)alkyl, halomethyl, haloethyl, halo(C3)alkyl, halo(C4)alkyl, halo(C5)alkyl, halo(C6)alkyl, halo(C7)alkyl, halo(C8)alkyl, methoxy, ethoxy, (C3)alkoxy, (C4)alkoxy, (C5)alkoxy, (C6)alkoxy, (C7)alkoxy, (C8)alkoxy, halomethoxy, haloethoxy, halo(C3)alkoxy, halo(C4)alkoxy, halo(C5)alkoxy, halo(C6)alkoxy, halo(C7)alkoxy, and halo(C8)alkoxy.
In another embodiment of this invention R2 and R4 are selected from F, Cl, Br, I, CN, and NO2 and R1, R3, and R5 are H.
In another embodiment of this invention R2, R3, and R4 are selected from F, Cl, Br, I, CN, and NO2 and R1, and R5 are H.
In another embodiment of this invention R2, R3, and R4 are independently selected from F and Cl and R1 and R5 are H.
In another embodiment of this invention R1 is selected from Cl and H.
In another embodiment of this invention R2 is selected from CF3, CH3, Cl, F, and H.
In another embodiment of this invention R3 is selected from OCH3, CH3, F, Cl, or H.
In another embodiment of this invention R4 is selected from CF3, CH3, Cl, F, and H.
In another embodiment of this invention R5 is selected from F, Cl, and H.
In another embodiment of this invention R6 may be selected from any combination of one or more of the following—halomethyl, haloethyl, halo(C3)alkyl, halo(C4)alkyl, halo(C5)alkyl, halo(C6)alkyl, halo(C7)alkyl, and halo(C8)alkyl.
In another embodiment of this invention R6 is trifluoromethyl.
In another embodiment of this invention R7 may be selected from any combination of one or more of the following —H, F, Cl, Br, and I.
In another embodiment of this invention R7 is selected from H, OCH3, and OH.
In another embodiment of this invention R8 may be selected from any combination of one or more of the following —H, methyl, ethyl, (C3)alkyl, (C4)alkyl, (C5)alkyl, (C6)alkyl, (C7)alkyl, (C8)alkyl, halomethyl, haloethyl, halo(C3)alkyl, halo(C4)alkyl, halo(C5)alkyl, halo(C6)alkyl, halo(C7)alkyl, and halo(C8)alkyl.
In another embodiment of this invention R8 is selected from CH3 and H.
In another embodiment of this invention R9 may be selected from any combination of one or more of the following —H, F, Cl, Br, I, methyl, ethyl, (C3)alkyl, (C4)alkyl, (C5)alkyl, (C6)alkyl, (C7)alkyl, (C8)alkyl, halomethyl, haloethyl, halo(C3)alkyl, halo(C4)alkyl, halo(C5)alkyl, halo(C6)alkyl, halo(C7)alkyl, halo(C8)alkyl, methoxy, ethoxy, (C3)alkoxy, (C4)alkoxy, (C5)alkoxy, (C6)alkoxy, (C7)alkoxy, (C8)alkoxy, halomethoxy, haloethoxy, halo(C3)alkoxy, halo(C4)alkoxy, halo(C5)alkoxy, halo(C6)alkoxy, halo(C7)alkoxy, and halo(C8)alkoxy.
In another embodiment of this invention R10 may be selected from any combination of one or more of the following —H, F, Cl, Br, I, CN, methyl, ethyl, (C3)alkyl, (C4)alkyl, (C5)alkyl, (C6)alkyl, (C7)alkyl, (C8)alkyl, halomethyl, haloethyl, halo(C3)alkyl, halo(C4)alkyl, halo(C5)alkyl, halo(C6)alkyl, halo(C7)alkyl, halo(C8)alkyl, methoxy, ethoxy, (C3)alkoxy, (C4)alkoxy, (C5)alkoxy, (C6)alkoxy, (C7)alkoxy, (C8)alkoxy, halomethoxy, haloethoxy, halo(C3)alkoxy, halo(C4)alkoxy, halo(C5)alkoxy, halo(C6)alkoxy, halo(C7)alkoxy, halo(C8)alkoxy, cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl.
In another embodiment of this invention R10 may be selected from any combination of one or more of the following —H, Cl, Br, CH3, and CF3.
In another embodiment of this invention R10 is selected from Br, C(═NOH)NH2, C(═O)H, C(═O)NH2, C(═O)OCH2CH3, C(═O)OH, CF3, CH2CH3, CH2OH, CH3, Cl, CN, F, H, NH2, NHC(═O)H, NHCH3, NO2, OCH3, OCHF2, and pyridyl.
In another embodiment of this invention R11 may be selected from any combination of one or more of the following —C(═O)N(H)(C((CH3)2)C(═O)N(H)(CH2CF3)), C(═O)N(H)(CH(CH3)C(═O)N(H)(CH2CF3)), C(═O)N(H)(CH(CH2CH3)C(═O)N(H)(CH2CF3)), C(═O)N(H)(CH(CH3)C(═S)N(H)(CH2CF3)), C(═O)N(H)(C((CH3)2)C(═S)N(H)(CH2CF3)), and C(═S)N(H)(C((CH3)2)C(═S)N(H)(CH2CF3)).
In another embodiment of this invention R11 is C(═(O or S))N(H)(((C1-C8)alkyl)C(═(O or S))N(H)(halo(C1-C8)alkyl)), which may be used in combination with any embodiment of R1 through R10 and X1 through X3.
In another embodiment of this invention R12 may be selected from any combination of one or more of the following —H, F, Cl, Br, I, methyl, ethyl, (C3)alkyl, (C4)alkyl, (C5)alkyl, (C6)alkyl, (C7)alkyl, (C8)alkyl, halomethyl, haloethyl, halo(C3)alkyl, halo(C4)alkyl, halo(C5)alkyl, halo(C6)alkyl, halo(C7)alkyl, halo(C8)alkyl, halomethoxy, haloethoxy, halo(C3)alkoxy, halo(C4)alkoxy, halo(C5)alkoxy, halo(C6)alkoxy, halo(C7)alkoxy, and halo(C8)alkoxy.
In another embodiment of this invention R12 is selected from CH3, and H.
In another embodiment of this invention R13 may be selected from any combination of one or more of the following —H, F, Cl, Br, I, methyl, ethyl, (C3)alkyl, (C4)alkyl, (C5)alkyl, (C6)alkyl, (C7)alkyl, (C8)alkyl, halomethyl, haloethyl, halo(C3)alkyl, halo(C4)alkyl, halo(C5)alkyl, halo(C6)alkyl, halo(C7)alkyl, halo(C8)alkyl, halomethoxy, haloethoxy, halo(C3)alkoxy, halo(C4)alkoxy, halo(C5)alkoxy, halo(C6)alkoxy, halo(C7)alkoxy, and halo(C8)alkoxy.
In another embodiment of this invention R13 is selected from CH3, Cl and H.
In another embodiment of this invention R12-R13 are a hydrocarbyl linkage containing CH═CHCH═CH.
In another embodiment of this invention R14 may be selected from any combination of one or more of the following —H, methyl, ethyl, (C3)alkyl, (C4)alkyl, (C5)alkyl, (C6)alkyl, (C7)alkyl, (C8)alkyl, halomethyl, haloethyl, halo(C3)alkyl, halo(C4)alkyl, halo(C5)alkyl, halo(C6)alkyl, halo(C7)alkyl, halo(C8)alkyl, methyl-aryl, ethyl-aryl, (C3)alkyl-aryl, (C4)alkyl-aryl, (C5)alkyl-aryl, (C6)alkyl-aryl, (C7)alkyl-aryl, (C8)alkyl-aryl, methyl-(substituted-aryl), ethyl-(substituted-aryl), (C3)alkyl-(substituted-aryl), (C4)alkyl-(substituted-aryl), (C5)alkyl-(substituted-aryl), (C6)alkyl-(substituted-aryl), (C7)alkyl-(substituted-aryl), (C8)alkyl-(substituted-aryl), O-methyl-aryl, O-ethyl-aryl, O—(C3)alkyl-aryl, O—(C4)alkyl-aryl, O—(C5)alkyl-aryl, O—(C6)alkyl-aryl, O—(C7)alkyl-aryl, O—(C8)alkyl-aryl, O-methyl-(substituted-aryl), O-ethyl-(substituted-aryl), O—(C3)alkyl-(substituted-aryl), O—(C4)alkyl-(substituted-aryl), O—(C5)alkyl-(substituted-aryl), O—(C6)alkyl-(substituted-aryl), O—(C7)alkyl-(substituted-aryl), O—(C8)alkyl-(substituted-aryl), methyl-heterocyclyl, ethyl-heterocyclyl, (C3)alkyl-heterocyclyl, (C4)alkyl-heterocyclyl, (C5)alkyl-heterocyclyl, (C6)alkyl-heterocyclyl, (C7)alkyl-heterocyclyl, (C8)alkyl-heterocyclyl, methyl-(substituted-heterocyclyl), ethyl-(substituted-heterocyclyl), (C3)alkyl-(substituted-heterocyclyl), (C4)alkyl-(substituted-heterocyclyl), (C5)alkyl-(substituted-heterocyclyl), (C6)alkyl-(substituted-heterocyclyl), (C7)alkyl-(substituted-heterocyclyl), (C8)alkyl-(substituted-heterocyclyl), O-methyl-heterocyclyl, O-ethyl-heterocyclyl, O—(C3)alkyl-heterocyclyl, O—(C4)alkyl-heterocyclyl, O—(C5)alkyl-heterocyclyl, O—(C6)alkyl-heterocyclyl, O—(C7)alkyl-heterocyclyl, O—(C8)alkyl-heterocyclyl, O-methyl-(substituted-heterocyclyl), O-ethyl-(substituted-heterocyclyl), O—(C3)alkyl-(substituted-heterocyclyl), O—(C4)alkyl-(substituted-heterocyclyl), O—(C5)alkyl-(substituted-heterocyclyl), O—(C6)alkyl-(substituted-heterocyclyl), O—(C7)alkyl-(substituted-heterocyclyl), O—(C8)alkyl-(substituted-heterocyclyl), methyl-C(═O)N(R16)(R17), ethyl-C(═O)N(R16)(R17), (C3)alkyl-C(═O)N(R16)(R17), (C4)alkyl-C(═O)N(R16)(R17), (C5)alkyl-C(═O)N(R16)(R17), (C6)alkyl-C(═O)N(R16)(R17), (C7)alkyl-C(═O)N(R16)(R17), and (C8)alkyl-C(═O)N(R16)(R17).
In another embodiment of this invention R14 may be selected from any combination of one or more of the following —H, CH3, CH2CF3, CH2-halopyridyl, oxo-pyrrolidinyl, halophenyl, thietanyl, CH2-phenyl, CH2-pyridyl, thietanyl-dioxide, CH2-halothiazolyl, C((CH3)2)-pyridyl, N(H)(halophenyl), CH2-pyrimidinyl, CH2-tetrahydrofuranyl, CH2-furanyl, O—CH2-halopyridyl, and CH2C(═O)N(H)(CH2CF3).
In another embodiment of this invention R15 may be selected from any combination of one or more of the following —H, methyl, ethyl, (C3)alkyl, (C4)alkyl, (C5)alkyl, (C6)alkyl, (C7)alkyl, (C8)alkyl, halomethyl, haloethyl, halo(C3)alkyl, halo(C4)alkyl, halo(C5)alkyl, halo(C6)alkyl, halo(C7)alkyl, halo(C8)alkyl, methyl-aryl, ethyl-aryl, (C3)alkyl-aryl, (C4)alkyl-aryl, (C5)alkyl-aryl, (C6)alkyl-aryl, (C7)alkyl-aryl, (C8)alkyl-aryl, methyl-(substituted-aryl), ethyl-(substituted-aryl), (C3)alkyl-(substituted-aryl), (C4)alkyl-(substituted-aryl), (C5)alkyl-(substituted-aryl), (C6)alkyl-(substituted-aryl), (C7)alkyl-(substituted-aryl), (C8)alkyl-(substituted-aryl), O-methyl-aryl, O-ethyl-aryl, O—(C3)alkyl-aryl, O—(C4)alkyl-aryl, O—(C5)alkyl-aryl, O—(C6)alkyl-aryl, O—(C7)alkyl-aryl, O—(C8)alkyl-aryl, O-methyl-(substituted-aryl), O-ethyl-(substituted-aryl), O—(C3)alkyl-(substituted-aryl), O—(C4)alkyl-(substituted-aryl), O—(C5)alkyl-(substituted-aryl), O—(C6)alkyl-(substituted-aryl), O—(C7)alkyl-(substituted-aryl), O—(C8)alkyl-(substituted-aryl), methyl-heterocyclyl, ethyl-heterocyclyl, (C3)alkyl-heterocyclyl, (C4)alkyl-heterocyclyl, (C5)alkyl-heterocyclyl, (C6)alkyl-heterocyclyl, (C7)alkyl-heterocyclyl, (C8)alkyl-heterocyclyl, methyl-(substituted-heterocyclyl), ethyl-(substituted-heterocyclyl), (C3)alkyl-(substituted-heterocyclyl), (C4)alkyl-(substituted-heterocyclyl), (C5)alkyl-(substituted-heterocyclyl), (C6)alkyl-(substituted-heterocyclyl), (C7)alkyl-(substituted-heterocyclyl), (C8)alkyl-(substituted-heterocyclyl), O-methyl-heterocyclyl, O-ethyl-heterocyclyl, O—(C3)alkyl-heterocyclyl, O—(C4)alkyl-heterocyclyl, O—(C5)alkyl-heterocyclyl, O—(C6)alkyl-heterocyclyl, O—(C7)alkyl-heterocyclyl, O—(C8)alkyl-heterocyclyl, O-methyl-(substituted-heterocyclyl), O-ethyl-(substituted-heterocyclyl), O—(C3)alkyl-(substituted-heterocyclyl), O—(C4)alkyl-(substituted-heterocyclyl), O—(C5)alkyl-(substituted-heterocyclyl), O—(C6)alkyl-(substituted-heterocyclyl), O—(C7)alkyl-(substituted-heterocyclyl), O—(C8)alkyl-(substituted-heterocyclyl), methyl-C(═O)N(R16)(R17), ethyl-C(═O)N(R16)(R17), (C3)alkyl-C(═O)N(R16)(R17), (C4)alkyl-C(═O)N(R16)(R17), (C5)alkyl-C(═O)N(R16)(R17), (C6)alkyl-C(═O)N(R16)(R17), (C7)alkyl-C(═O)N(R16)(R17), and (C8)alkyl-C(═O)N(R16)(R17).
In another embodiment of this invention R15 may be selected from any combination of one or more of the following —H, CH3, CH2CF3, CH2-halopyridyl, oxo-pyrrolidinyl, halophenyl, thietanyl, CH2-phenyl, CH2-pyridyl, thietanyl-dioxide, CH2-halothiazolyl, C((CH3)2)-pyridyl, N(H)(halophenyl), CH2-pyrimidinyl, CH2-tetrahydrofuranyl, CH2-furanyl, O—CH2-halopyridyl, and CH2C(═O)N(H)(CH2CF3).
In another embodiment of this invention R16 may be selected from any combination of one or more of the following —H, methyl, ethyl, (C3)alkyl, (C4)alkyl, (C5)alkyl, (C6)alkyl, (C7)alkyl, (C8)alkyl, halomethyl, haloethyl, halo(C3)alkyl, halo(C4)alkyl, halo(C5)alkyl, halo(C6)alkyl, halo(C7)alkyl, halo(C8)alkyl, methyl-aryl, ethyl-aryl, (C3)alkyl-aryl, (C4)alkyl-aryl, (C5)alkyl-aryl, (C6)alkyl-aryl, (C7)alkyl-aryl, (C8)alkyl-aryl, methyl-(substituted-aryl), ethyl-(substituted-aryl), (C3)alkyl-(substituted-aryl), (C4)alkyl-(substituted-aryl), (C5)alkyl-(substituted-aryl), (C6)alkyl-(substituted-aryl), (C7)alkyl-(substituted-aryl), (C8)alkyl-(substituted-aryl), O-methyl-aryl, O-ethyl-aryl, O—(C3)alkyl-aryl, O—(C4)alkyl-aryl, O—(C5)alkyl-aryl, O—(C6)alkyl-aryl, O—(C7)alkyl-aryl, O—(C8)alkyl-aryl, O-methyl-(substituted-aryl), O-ethyl-(substituted-aryl), O—(C3)alkyl-(substituted-aryl), O—(C4)alkyl-(substituted-aryl), O—(C5)alkyl-(substituted-aryl), O—(C6)alkyl-(substituted-aryl), O—(C7)alkyl-(substituted-aryl), O—(C8)alkyl-(substituted-aryl), methyl-heterocyclyl, ethyl-heterocyclyl, (C3)alkyl-heterocyclyl, (C4)alkyl-heterocyclyl, (C5)alkyl-heterocyclyl, (C6)alkyl-heterocyclyl, (C7)alkyl-heterocyclyl, (C8)alkyl-heterocyclyl, methyl-(substituted-heterocyclyl), ethyl-(substituted-heterocyclyl), (C3)alkyl-(substituted-heterocyclyl), (C4)alkyl-(substituted-heterocyclyl), (C5)alkyl-(substituted-heterocyclyl), (C6)alkyl-(substituted-heterocyclyl), (C7)alkyl-(substituted-heterocyclyl), (C8)alkyl-(substituted-heterocyclyl), O-methyl-heterocyclyl, O-ethyl-heterocyclyl, O—(C3)alkyl-heterocyclyl, O—(C4)alkyl-heterocyclyl, O—(C5)alkyl-heterocyclyl, O—(C6)alkyl-heterocyclyl, O—(C7)alkyl-heterocyclyl, O—(C8)alkyl-heterocyclyl, O-methyl-(substituted-heterocyclyl), O-ethyl-(substituted-heterocyclyl), O—(C3)alkyl-(substituted-heterocyclyl), O—(C4)alkyl-(substituted-heterocyclyl), O—(C5)alkyl-(substituted-heterocyclyl), O—(C6)alkyl-(substituted-heterocyclyl), O—(C7)alkyl-(substituted-heterocyclyl), and O—(C8)alkyl-(substituted-heterocyclyl).
In another embodiment of this invention R16 may be selected from any combination of one or more of the following —H, CH2CF3, cyclopropyl, thietanyl, thietanyl dioxide, and halophenyl.
In another embodiment of this invention R17 may be selected from any combination of one or more of the following —H, methyl, ethyl, (C3)alkyl, (C4)alkyl, (C5)alkyl, (C6)alkyl, (C7)alkyl, (C8)alkyl, halomethyl, haloethyl, halo(C3)alkyl, halo(C4)alkyl, halo(C5)alkyl, halo(C6)alkyl, halo(C7)alkyl, halo(C8)alkyl, methyl-aryl, ethyl-aryl, (C3)alkyl-aryl, (C4)alkyl-aryl, (C5)alkyl-aryl, (C6)alkyl-aryl, (C7)alkyl-aryl, (C8)alkyl-aryl, methyl-(substituted-aryl), ethyl-(substituted-aryl), (C3)alkyl-(substituted-aryl), (C4)alkyl-(substituted-aryl), (C5)alkyl-(substituted-aryl), (C6)alkyl-(substituted-aryl), (C7)alkyl-(substituted-aryl), (C8)alkyl-(substituted-aryl), O-methyl-aryl, O-ethyl-aryl, O—(C3)alkyl-aryl, O—(C4)alkyl-aryl, O—(C5)alkyl-aryl, O—(C6)alkyl-aryl, O—(C7)alkyl-aryl, O—(C8)alkyl-aryl, O-methyl-(substituted-aryl), O-ethyl-(substituted-aryl), O—(C3)alkyl-(substituted-aryl), O—(C4)alkyl-(substituted-aryl), O—(C5)alkyl-(substituted-aryl), O—(C6)alkyl-(substituted-aryl), O—(C7)alkyl-(substituted-aryl), O—(C8)alkyl-(substituted-aryl), methyl-heterocyclyl, ethyl-heterocyclyl, (C3)alkyl-heterocyclyl, (C4)alkyl-heterocyclyl, (C5)alkyl-heterocyclyl, (C6)alkyl-heterocyclyl, (C7)alkyl-heterocyclyl, (C8)alkyl-heterocyclyl, methyl-(substituted-heterocyclyl), ethyl-(substituted-heterocyclyl), (C3)alkyl-(substituted-heterocyclyl), (C4)alkyl-(substituted-heterocyclyl), (C5)alkyl-(substituted-heterocyclyl), (C6)alkyl-(substituted-heterocyclyl), (C7)alkyl-(substituted-heterocyclyl), (C8)alkyl-(substituted-heterocyclyl), O-methyl-heterocyclyl, O-ethyl-heterocyclyl, O—(C3)alkyl-heterocyclyl, O—(C4)alkyl-heterocyclyl, O—(C5)alkyl-heterocyclyl, O—(C6)alkyl-heterocyclyl, O—(C7)alkyl-heterocyclyl, O—(C8)alkyl-heterocyclyl, O-methyl-(substituted-heterocyclyl), O-ethyl-(substituted-heterocyclyl), O—(C3)alkyl-(substituted-heterocyclyl), O—(C4)alkyl-(substituted-heterocyclyl), O—(C5)alkyl-(substituted-heterocyclyl), O—(C6)alkyl-(substituted-heterocyclyl), O—(C7)alkyl-(substituted-heterocyclyl), and O—(C8)alkyl-(substituted-heterocyclyl).
In another embodiment of this invention R17 may be selected from any combination of one or more of the following —H, CH2CF3, cyclopropyl, thietanyl, thietanyl dioxide, and halophenyl.
In another embodiment of this invention X1 is CR12, X2 is CR13, and X3 is CR9.
In another embodiment of this invention a heterocyclyl has preferably about 6 to 10 atoms in the ring structure, more preferably, 6 to 8 atoms.
The molecules of Formula One will generally have a molecular mass of about 100 Daltons to about 1200 Daltons. However, it is generally preferred if the molecular mass is from about 120 Daltons to about 900 Daltons, and it is even more generally preferred if the molecular mass is from about 140 Daltons to about 600 Daltons.
The benzyl alcohol of Formula IV, wherein R1, R2, R3, R4, R5, R6, and R7 are as previously disclosed, can be synthesized in two ways. One way, disclosed in step a of Scheme I, is by treatment of the ketone of Formula II, wherein R1, R2, R3, R4, R5, and R6 are as previously disclosed, with a reducing agent, such as sodium borohydride (NaBH4), under basic conditions, such as aqueous sodium hydroxide (NaOH), in a polar protic solvent, such as methyl alcohol (MeOH) at 0° C. Alternatively, an aldehyde of Formula III, wherein R1, R2, R3, R4, R5, and R7 are as previously disclosed, is allowed to react with trifluorotrimethylsilane in the presence of a catalytic amount of tetrabutylammonium fluoride (TBAF) in a polar aprotic solvent, such as tetrahydrofuran (THF), as in step b of Scheme I. The compound of Formula IV can be transformed into the compound of Formula V, wherein Y is selected from Br, Cl or I, and R1, R2, R3, R4, R5, R6, and R7 are as previously disclosed, by reaction with a halogenating reagent, such as N-bromosuccinimide (NBS) and triethyl phosphite in a non-reactive solvent, such as dichloromethane (CH2Cl2) at reflux temperature to provide Y═Br, or such as thionyl chloride and pyridine in a hydrocarbon solvent, such as toluene at reflux temperature to provide Y═Cl, as in step c of Scheme I.




Formation of the styrene coupling partners can be accomplished as in Schemes II, III IV and V.
In Scheme II, a vinylbenzoic acid of Formula VI, wherein R11 is (C═O)OH and R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, can be converted in two steps to the vinylbenzamide of Formula VIIa, wherein R11 is (C═O)N(R14)(R15), and R8, R9, R10, R12, R13, R14, R15, and X are as previously disclosed. As in step d of Scheme II, the benzoic acid of Formula VI is treated with oxalyl chloride in the presence of a catalytic amount of N,N-dimethylformamide (DMF) in a non-reactive solvent such as CH2Cl2 to form the acid chloride, which is subsequently allowed to react with an amine (HN(R14)(R15)), wherein R14 and R15 are as previously disclosed, in the presence of a base, such as triethylamine (TEA), in a polar aprotic solvent, such as THF, to provide the vinyl benzamide of Formula VIIa, wherein R11 is (C═O)N(R14)(R15), and R8, R9, R10, R12, R13, R14, R15, X1, X2, and X3 are as previously disclosed, as in step e of Scheme II.




In Schemes III and IV, a halobenzoic acid of Formula VIII, wherein R18 is Br or I, R11 is (C═O)OH and R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed can be converted to a vinylbenzoic acid ester of Formula VIIb1 or Formula VIIb2, wherein R18 is Br or I, R11 is (C═O)O(C1-C6 alkyl), and R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed. In step f of Scheme III, the halobenzoic acid of Formula VIII, wherein R18 is Br, is treated with a base, such as n-butyllithium (n-BuLi), and DMF in a polar, aprotic solvent, such as THF, at a temperature of about −78° C. The resulting formyl benzoic acid is allowed to react with an acid, such as sulfuric acid (H2SO4), in the presence of an alcohol, such as ethyl alcohol (EtOH), as in step g, to provide the formyl benzoic acid ethyl ester of Formula IX, wherein R11 is (C═O)O(C1-C6 alkyl), and R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed. The vinyl benzoic acid ester of Formula VIIb1 is accessed via reaction of the compounds of Formula IX, with a base, such as potassium carbonate (K2CO3), and methyl triphenyl phosphonium bromide in a polar aprotic solvent, such as 1,4-dioxane, at ambient temperature, as in step h of Scheme III.




In step i of Scheme IV, the halobenzoic acid of Formula VIII, wherein R18 is Br, R11 is (C═O)OH, and R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, is treated with di-tert-butyl dicarbonate in the presence of a base, such as TEA and a catalytic amount of 4-(dimethylamino)pyridine (DMAP) in a polar aprotic solvent, such as THF, at ambient temperature. The resulting benzoic acid tert-butyl ester is allowed to react with vinyl boronic anhydride pyridine complex in the presence of a palladium catalyst, such a tetrakis(triphenylphospine)palladium(0) (Pd(PPh3)4), and a base, such as K2CO3, in a non-reactive solvent such as toluene at reflux temperature, as in step j, to provide the vinyl benzoic acid ester of Formula VIIb2, wherein R11 is (C═O)O(C1-C6 alkyl), and R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed.




In step k of Scheme V, the vinyl benzoic acid ester of Formula VIIb2, wherein R10 is Br, R11 is (C═O)O(C1-C6 alkyl), and R8, R9, R12, R13, X1, X2, and X3 are as previously defined, can be further transformed into the corresponding vinyl benzoic acid ester of Formula VIIb3, wherein R10 is CN, R11 is (C═O)O(C1-C6 alkyl), and R8, R9, R12, R13, X1, X2, and X3 are as previously disclosed, by reaction with copper(I) cyanide (CuCN) in a polar aprotic solvent, such as DMF, at 140° C.




Coupling of the compounds of Formula V with the compounds of Formula VIIa, VIIb1, VIIb2 and VIIb3 can be accomplished as in Schemes VI, VII, and VIII. In step l of Scheme VI, a compound of Formula V, wherein Y, R1, R2, R3, R4, R5, R6, and R7 are as previously disclosed, and the vinylbenzamide of Formula VIIa, wherein R11 is (C═O)N(R14)(R15), and R8, R9, R10, R12, R13, R14, R15, X1, X2, and X3 are as previously disclosed, are allowed to react in the presence of copper(I) chloride (CuCl) and 2,2-bipyridyl in a solvent, such as 1,2-dichlorobenzene, at a temperature of about 180° C. to provide the molecules of Formula One, wherein R11 is (C═O)N(R14)(R15), and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, R14, R15, X1, X2, and X3 are as previously disclosed.




In step l of Scheme VII, the compound of Formula V, wherein Y, R1, R2, R3, R4, R5, R6, and R7 are as previously disclosed, and the vinylbenzoic acid ester of Formula VIIb1, wherein R11 is (C═O)O(C1-C6 alkyl), and R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, are allowed to react in the presence of CuCl and 2,2-bipyridyl in a solvent, such as 1,2-dichlorobenzene, at a temperature of about 180° C. to provide the compounds of Formula Xa, wherein R11 is (C═O)O(C1-C6 alkyl), and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed. The compounds of Formula Xa are then converted to the molecules of Formula One, wherein R11 is (C═O)N(R14)(R15), and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, R14, R15, X1, X2, and X3 are as previously disclosed, by either a two-step process as disclosed in steps m and n or in one step as disclosed in step o. In step m of Scheme VII, the ester of Formula Xa is saponified to the corresponding acid under acidic conditions, such as about 11 Normal (N) hydrochloric acid (HCl), in a polar aprotic solvent, such as 1,4-dioxane, at about 100° C. The acid can subsequently be coupled to an amine (HN(R14)(R15)), wherein R14 and R15 are as previously disclosed using peptide coupling reagents, such as 1-hydroxybenzotriazole (HOBt), N-(3-dimethylaminopropyl)-N′-ethyl-carbodiimide hydrochloride (EDC.HCl), benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate (PyBOP), 2-chloro -1,3-dimethylimidazolidinium hexafluorophosphate (CIP), 1-hydroxy-7-azabenzotriazole (HOAt), or O-benzotriazole-N,N,N′,N′-tetramethyl-uronium-hexafluoro-phosphate (HBTU) in the presence of a base, such as N,N-diisopropylethylamine (DIPEA) or DMAP to give the molecules of Formula One, wherein R11 is (C═O)N(R14)(R15), and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, R14, R15, X1, X2, and X3 are as previously disclosed. Alternatively, the ester of Formula Xa is allowed to react with an amine (HN(R14)(R15)) in the presence of a solution of trimethylaluminum in toluene in a non-reactive solvent, such as CH2Cl2, at ambient temperature, as in step o of Scheme VII, to access the molecules of Formula One, wherein R11 is (C═O)N(R14)(R15), and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, R14, R15, X1, X2, and X3 are as previously disclosed.




In step l of Scheme VIII, the compound of Formula V, wherein Y, R1, R2, R3, R4, R5, R6, and R7 are as previously disclosed, and the vinylbenzoic acid ester of Formula VIIb2 or VIIb3, wherein R11 is (C═O)O(C1-C6 alkyl), and R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, are allowed to react in the presence of CuCl and 2,2-bipyridyl in a solvent, such as 1,2-dichlorobenzene, at a temperature of about 180° C. to provide the compounds of Formula Xb, wherein R11 is (C═O)OH, and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, R14, R15, X1, X2, and X3 are as previously disclosed. The compounds of Formula Xb are then converted to the molecules of Formula One, wherein R11 is (C═O)N(R14)(R15), and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, R14, R15, X1, X2, and X3 are as previously disclosed, in one step as disclosed in step n. In step n of Scheme VIII, the acid of Formula Xb can be coupled to an amine (HN(R14)(R15)), wherein R14 and R15 are as previously disclosed, using peptide coupling reagents, such as HOBt, EDC.HCl, PyBOP, CIP, HOAt, or HBTU in the presence of a base, such as DIPEA or DMAP to give the molecules of Formula One, wherein R11 is (C═O)N(R14)(R15), and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, R14, R15, X1, X2, and X3 are as previously disclosed.




In step t of Scheme XIII, the vinyl benzyl chloride of Formula XIa, wherein R11 is —CH2Cl and R8, R9, R10, R12, R13, X1, X2, and X3 are as previously defined, can be transformed into the corresponding phthalimide-protected benzyl amine of Formula XIIa, wherein R11 is CH2N(Phthalimide), and R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, by reaction with potassium phthalimide in a polar aprotic solvent, such as DMF, at 70° C.




In step u of Scheme XIV, the 4-methylbenzonitrile of Formula XIIIa, wherein R11 is CH3 and R9, R10, R12, R13, X1, X2, and X3 are as previously defined, can be transformed into the corresponding benzyl bromide of Formula XIVa, wherein R11 is CH2Br and R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, by reaction with NBS and azobisisobutyronitrile (AIBN) in a non-reactive solvent, such as carbon tetrachloride (CCl4) at 77° C. The nitrile group (CN) of Formula XIVa can be reduced to the corresponding aldehyde of Formula XVa, wherein R11 is CH2Br and R9, R10, R12, R13, X1, X2, and X3 are as previously defined via reaction with diisobutylaluminum hydride (DIBAL-H) in an aprotic solvent, such as toluene, at 0° C., followed by quenching with 1.0 M HCl as in step v of Scheme XIV. The compound of Formula XVa can be further transformed to the corresponding phthalimide-protected benzyl amine of Formula XVIa, wherein R11 is CH2N(Phthalimide) and R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, by reaction with potassium phthalimide in a polar aprotic solvent, such as DMF, at 60° C. as in step t of Scheme XIV. In step w of Scheme XIV, the aldehyde of Formula XVIa can be converted to the olefin of Formula XIIb, wherein R11 is CH2N(Phthalimide) and R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, by reaction with methyl triphenyl phosphonium bromide in a polar aprotic solvent, such as 1,4-dioxane, in the presence of a base, such as K2CO3, at ambient temperature.




The aldehyde of Formula XVa, wherein R11 is CH2Br and R9, R10, R12, R13, X1, X2, and X3 are as previously defined, can be reacted with a nucleophile, such as 2-aminopyridine, in a polar aprotic solvent, such as N,N-dimethylacetamide (DMA), in the presence of a base, such as K2CO3, at ambient temperature to provide the compound of Formula XVII, wherein R11 is CH2NH(2-pyridine) and R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, as in step x of Scheme XV. In step w of Scheme XV, the compound of Formula XVII can be converted to the olefin of Formula XVIII, wherein R11 is CH2NH(2-pyridine) and R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed.




In a two-step, one-pot reaction as in steps y and z of Scheme XVI, the compound of Formula XIX can be reacted with the compounds of Formula XX, wherein R10 and R11 are Cl, X1 is N, and R9, R13, X2, and X3 are as previously disclosed, in the presence of a base, such as sodium hydride (NaH), and a polar aprotic solvent, such as DMF, at ambient temperature to provide the compounds of Formula XXI, wherein R10 is Cl, R11 is (CH)NH2CO2CH2CH3, X1 is N, and R9, R13, X2, and X3 are as previously defined. Hydrolysis and decarboxylation of the compounds of Formula XXI can be accomplished by reaction under acidic conditions, such as with 3 N HCl, at reflux temperature, to afford the compounds of Formula XXII, wherein R10 is Cl, R11 is CH2NH2.HCl, X1 is N, and R9, R13, X2, and X3 are as previously disclosed, as in step aa in Scheme XVI. The compounds of Formula XXII can be further transformed to the corresponding phthalimide-protected benzyl amines of Formula XXIIIa, wherein R10 is Cl, R11 is CH2N(Phthalimide), X1 is N, and R9, R13, X1, X2, and X3 are as previously disclosed, by reaction with phthalic anhydride in the presence of a base, such as TEA, and an aprotic solvent, such as toluene, at reflux temperature as in step ab of Scheme XVI. The bromide of Formula XXIIIa can be converted to the olefin of Formula XIIc, wherein R10 is Cl, R11 is CH2N(Phthalimide), X1 is N, and R8, R9, R13, X2 and X3 are as previously disclosed, by reaction with vinyl boronic anhydride pyridine complex in the presence of a palladium catalyst, such as Pd(PPh3)4, and a base, such as K2CO3, in a non-reactive solvent such as toluene at reflux temperature, as in step ac of Scheme XVI.




In step u of Scheme XVII, the 4-methylnaphthonitrile of Formula XIIIb, wherein X3 is CR9, R10 and X3 together form a linkage having 4 carbon atoms and with the ring carbon atoms form a 6-membered aromatic ring, R11 is CH3, and R12, R13, X1 and X2 are as previously defined, can be transformed into the corresponding naphthyl bromide of Formula XIVb, wherein X3 is CR9, R10 and X3 together form a linkage having 4 carbon atoms and with the ring carbon atoms form a 6-membered aromatic ring, R11 is CH2Br, and R12, R13, X1 and X2 are as previously disclosed, by reaction with NBS and AIBN in a non-reactive solvent, such as CCl4 at 77° C. The nitrile group (CN) of Formula XIVb can be reduced to the corresponding aldehyde of Formula XVb, wherein X3 is CR9, R10 and X3 together form a linkage having 4 carbon atoms and with the ring carbon atoms form a 6-membered aromatic ring (or if desired a non-aromatic ring), R11 is CH2Br, and R12, R13, X1 and X2 are as previously defined via reaction with diisobutylaluminum hydride (DIBAL-H) in an aprotic solvent, such as toluene, at 0° C., followed by quenching with 1.0 M HCl as in step v of Scheme XVII. The compound of Formula XVb can be further transformed to the corresponding phthalimide-protected benzyl amine of Formula XVIb, wherein X3 is CR9, R10 and X3 together form a linkage having 4 carbon atoms and with the ring carbon atoms form a 6-membered aromatic ring, R11 is CH2N(Phthalimide), and R12, R13, X1 and X2 are as previously disclosed, by reaction with potassium phthalimide in a polar aprotic solvent, such as DMF, at 60° C. as in step t of Scheme XVII. In step w of Scheme XVII, the aldehyde of Formula XVIb can be converted to the olefin of Formula XIId, wherein X3 is CR9, R10 and X3 together form a linkage having 4 carbon atoms and with the ring carbon atoms form a 6-membered aromatic ring, R11 is CH2N(Phthalimide), and R8, R12, R13, X1 and X2 are as previously disclosed, by reaction with methyl triphenyl phosphonium bromide in a polar aprotic solvent, such as 1,4-dioxane, in the presence of a base, such as K2CO3, at ambient temperature.




The compound of Formula XXIV, wherein R11 is NHNH2.HCl and R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, can be transformed into the corresponding phthalimide-protected hydrazine of Formula XXV, wherein R11 is NHN(Phthalimide) and R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, by reaction with phthalic anhydride in glacial acetic acid (AcOH) at reflux temperature as in step ad of Scheme XVIII. The bromide of Formula XXV can be converted to the olefin of Formula XIIe, wherein R11 is NHN(Phthalimide) and R8, R9, R10, R13, X1, X2 and X3 are as previously disclosed, by reaction with vinyl boronic anhydride pyridine complex in the presence of a palladium catalyst, such as Pd(PPh3)4, and a base, such as K2CO3, in a polar aprotic solvent such as 1,2-dimethoxyethane at 150° C. under microwave conditions, as in step ae of Scheme XVIII.




In step af of Scheme XIX, the compound of Formula XXVI, wherein R11 is B(OH)2, and R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, are allowed to react with 2-hydroxyisoindoline-1,3-dione in the presence of CuCl and pyridine in a solvent, such as 1,2-dichlorobenzene, at ambient temperature to provide the compound of Formula XIIf, wherein R11 is ON(Phthalimide) and R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed.




In step l of Scheme XX, the compound of Formula V, wherein Y, R1, R2, R3, R4, R5, R6, and R7 are as previously disclosed, and the compounds of Formula XIIa, wherein R11 is CH2N(Phthalimide) and R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, are allowed to react in the presence of CuCl and 2,2-bipyridyl in a solvent, such as 1,2-dichlorobenzene, at a temperature of about 180° C. to provide the corresponding compounds of Formula XXVIIa, wherein R11 is CH2N(Phthalimide) and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed. The phthalimide protecting group in the compounds of Formula XXVIIa is removed as in step ag of Scheme XX by reaction with hydrazine hydrate in a polar protic solvent such as EtOH at 90° C. to provide the compounds of Formula XXVIIIa, wherein R11 is CH2NH2 and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed. The compounds of Formula XXVIIIa can be transformed into the compounds of Formula One, wherein R11 is CH2N(C═O)(R14) and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, by acylation with an anhydride, such as acetic anhydride, and a base, such as TEA, in a non-reactive solvent such as CH2Cl2 at 0° C. as in step ah1 of Scheme XX.




In step l of Scheme XXI, the compound of Formula V, wherein Y, R1, R2, R3, R4, R5, R6, and R7 are as previously disclosed, and the compounds of Formula XIIb, wherein R11 is CH2N(Phthalimide) and R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, are allowed to react in the presence of CuCl and 2,2-bipyridyl in a solvent, such as 1,2-dichlorobenzene, at a temperature of about 180° C. to provide the corresponding compounds of Formula XXVIIb, wherein R11 is CH2N(Phthalimide) and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed. The phthalimide protecting group in the compounds of Formula XXVIIb is removed as in step ag of Scheme XXI by reaction with hydrazine hydrate in a polar protic solvent such as EtOH at 90° C. to provide the compounds of Formula XXVIIIb, wherein R11 is CH2NH2 and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed. The compounds of Formula XXVIIIb can be transformed into the compounds of Formula One, wherein R11 is CH2N(C═O)(R14) and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, by reaction with an acid in the presence of HOBt.H2O, EDC.HCl and a base, such as DIPEA, in a polar aprotic solvent, such as DMF, as in step ah2a of Scheme XXI.
In another embodiment, the compounds of Formula XXVIIIb can be transformed into the compounds of Formula One, wherein R11 is CH2N(C═S)(R14) and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, by reaction with a thioacid in the presence of HOBt.H2O, EDC.HCl and a base, such as DIPEA, in a polar aprotic solvent, such as DMF, as in step ah2 of Scheme XXI.
In another embodiment, the compounds of Formula XXVIIIb can be transformed into the compounds of Formula One, wherein R11 is CH2N(C═O)N(R14)(R15) and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, in two steps. The first step (step ah3a of Scheme XXI) involves reaction with an aldehyde in a polar protic solvent such as MeOH, followed by reaction with NaBH4. The second step (step ah3b of Scheme XXI) involves acylation with an acid chloride, such as cyclopropylcarbonyl chloride, and a base, such as TEA, in a non-reactive solvent such as CH2Cl2 at ambient temperature of Scheme XXI.
In another embodiment, the compounds of Formula XXVIIIb can be transformed into the compounds of Formula One, wherein R11 is CH2N(C═O)N(R14)(R15) and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, by reaction with an isocyanate (step ai1 of Scheme XXI) or a carbamoyl chloride (step ai2 of Scheme XXI) in the presence of a base such as TEA and in a non-reactive solvent such as CH2Cl2 at 0° C.
In another embodiment, the compounds of Formula XXVIIIb can be transformed into the compounds of Formula One, wherein R11 is CH2N(C═S)N(R14)(R15) and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, by reaction with an isothiocyanate in the presence of a base such as TEA and in a non-reactive solvent such as CH2Cl2 at 0° C., as in steps aj of Scheme XXI.
In another embodiment, the compounds of Formula XXVIIIb can be transformed into the compounds of Formula One, wherein R11 is CH2N(C═O)O(R14) and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, by reaction with a dicarbonate, such as di-tert-butyl dicarbonate in the presence of a base such as TEA and in a non-reactive solvent such as CH2Cl2 at ambient temperature, as in steps ak of Scheme XXI.
In yet another embodiment, the compounds of Formula XXVIIIb can be transformed into the compounds of Formula One, wherein R11 is CH2N(C═O)(C═O)O(R14) and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, by reaction with a chlorooxalic acid ester, such as 2-chloro-2-oxoacetate in the presence of a base such as TEA and in a non-reactive solvent such as CH2Cl2 at 0° C., as in steps al of Scheme XXI.




In step l of Scheme XXII, the compound of Formula V, wherein Y, R1, R2, R3, R4, R5, R6, and R7 are as previously disclosed, and the compounds of Formula XIIc, wherein R10 is Cl, R11 is CH2N(Phthalimide), X1 is N, and R8, R9, R12, R13, X2, and X3 are as previously disclosed, are allowed to react in the presence of CuCl and 2,2-bipyridyl in a solvent, such as 1,2-dichlorobenzene, at a temperature of about 180° C. to provide the corresponding compounds of Formula XXVIIc, wherein R10 is Cl, R11 is CH2N(Phthalimide), X1 is N, and R1, R2, R3, R4, R5, R6, R7, R8, R9, R12, R13, X2, and X3 are as previously disclosed. The phthalimide protecting group in the compounds of Formula XXVIIc is removed as in step ag of Scheme XXII by reaction with hydrazine hydrate in a polar protic solvent such as EtOH at 90° C. to provide the compounds of Formula XXVIIIc, wherein R10 is Cl, R11 is CH2NH2, X1 is N, and R1, R2, R3, R4, R5, R6, R7, R8, R9, R12, R13, X2, and X3 are as previously disclosed. The compounds of Formula XXVIIIc can be transformed into the compounds of Formula One, wherein R10 is Cl, R11 is CH2N(C═O)(R14), X1 is N, and R1, R2, R3, R4, R5, R6, R7, R8, R9, R12, R13, X2, and X3 are as previously disclosed, by reaction with an acid in the presence of HOBt.H2O, EDC.HCl and a base, such as DIPEA, in a polar aprotic solvent, such as CH2Cl2, as in step ah2b of Scheme XXII.




In step l of Scheme XXIII, the compound of Formula V, wherein Y, R1, R2, R3, R4, R5, R6, and R7 are as previously disclosed, and the compounds of Formula XIId, wherein X3 is CR9, R10 and X3 together form a linkage having 4 carbon atoms and with the ring carbon atoms form a 6-membered aromatic ring (or if desired a non-aromatic ring), R11 is CH2N(Phthalimide) and R8, R9, R12, R13, X1 and X2 are as previously disclosed, are allowed to react in the presence of CuCl and 2,2-bipyridyl in a solvent, such as 1,2-dichlorobenzene, at a temperature of about 180° C. to provide the corresponding compounds of Formula XXVIId, wherein X3 is CR9, R10 and X3 together form a linkage having 4 carbon atoms and with the ring carbon atoms form a 6-membered aromatic ring, R11 is CH2N(Phthalimide) and R1, R2, R3, R4, R5, R6, R7, R8, R9, R12, R13, X1 and X2 are as previously disclosed. The phthalimide protecting group in the compounds of Formula XXVIId is removed as in step ag of Scheme XXIII by reaction with hydrazine hydrate in a polar protic solvent such as EtOH at 90° C. to provide the compounds of Formula XXVIIId, wherein X3 is CR9, R10 and X3 together form a linkage having 4 carbon atoms and with the ring carbon atoms form a 6-membered aromatic ring, R11 is CH2NH2 and R1, R2, R3, R4, R5, R6, R7, R8, R9, R12, R13, X1 and X2 are as previously disclosed. The compounds of Formula XXVIIId can be transformed into the compounds of Formula One, wherein X3 is CR9, R10 and X3 together form a linkage having 4 carbon atoms and with the ring carbon atoms form a 6-membered aromatic ring, R11 is CH2N(C═O)(R14) and R1, R2, R3, R4, R5, R6, R7, R8, R9, R12, R13, X1 and X2 are as previously disclosed, by reaction with an acid in the presence of HOBt.H2O, EDC.HCl and a base, such as DIPEA, in a polar aprotic solvent, such as CH2Cl2, as in step ah2b of Scheme XXIII.
In another embodiment, the compounds of Formula XXVIIId can be transformed into the compounds of Formula One, wherein X3 is CR9, R10 and X3 together form a linkage having 4 carbon atoms and with the ring carbon atoms form a 6-membered aromatic ring, R11 is CH2N(C═O)N(R14)(R15) and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, X1 and X2 are as previously disclosed, by reaction with an isocyanate in the presence of a base such as TEA and in a non-reactive solvent such as CH2Cl2 at 0° C. as in step ai1 of Scheme XXIII.




In step l of Scheme XXIV, the compound of Formula V, wherein Y, R1, R2, R3, R4, R5, R6, and R7 are as previously disclosed, and the compounds of Formula XIIe, wherein R11 is NHN(Phthalimide) and R8, R9, R12, R13, X1, X2, and X3 are as previously disclosed, are allowed to react in the presence of CuCl and 2,2-bipyridyl in a solvent, such as 1,2-dichlorobenzene, at a temperature of about 180° C. to provide the corresponding compounds of Formula XXVIIe, wherein R11 is NHN(Phthalimide) and R1, R2, R3, R4, R5, R6, R7, R8, R9, R12, R13, X1, X2, and X3 are as previously disclosed. The phthalimide protecting group in the compounds of Formula XXVIIe is removed as in step ag of Scheme XXIV by reaction with hydrazine hydrate in a polar protic solvent such as EtOH at 90° C. to provide the compounds of Formula XXVIIIe, wherein R11 is NHNH2 and R1, R2, R3, R4, R5, R6, R7, R8, R9, R12, R13, X1, X2, and X3 are as previously disclosed. The compounds of Formula XXVIIIe can be transformed into the compounds of Formula One, wherein R11 is NHN(C═O)(R14) and R1, R2, R3, R4, R5, R6, R7, R8, R9, R12, R13, X1, X2, and X3 are as previously disclosed, by reaction with an acid in the presence of HOBt.H2O, EDC.HCl and a base, such as DIPEA, in a polar aprotic solvent, such as CH2Cl2, as in step ah2b of Scheme XXIV.




In step l of Scheme XXV, the compound of Formula V, wherein Y, R1, R2, R3, R4, R5, R6, and R7 are as previously disclosed, and the compounds of Formula XIIf, wherein R11 is ON(Phthalimide) and R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, are allowed to react in the presence of CuCl and 2,2-bipyridyl in a solvent, such as 1,2-dichlorobenzene, at a temperature of about 180° C. to provide the corresponding compounds of Formula XXVIIf, wherein R11 is ON(Phthalimide) and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed. The phthalimide protecting group in the compounds of Formula XXVIIf is removed as in step ag of Scheme XXV by reaction with hydrazine hydrate in a polar protic solvent such as EtOH at 90° C. to provide the compounds of Formula XXVIIIf, wherein R11 is ONH2 and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed. The compounds of Formula XXVIIIf can be transformed into the compounds of Formula One, wherein R11 is ON(C═O)(R14) and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, by reaction with an acid in the presence of HOBt.H2O, EDC.HCl and a base, such as DIPEA, in a polar aprotic solvent, such as CH2Cl2, as in step ah2b of Scheme XXV.




In step l of Scheme XXVI, the compound of Formula V, wherein Y, R1, R2, R3, R4, R5, R6, and R7 are as previously disclosed, and the compounds of Formula XVIII, wherein R11 is CH2NH(2-pyridine) and R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed, are allowed to react in the presence of CuCl and 2,2-bipyridyl in a solvent, such as 1,2-dichlorobenzene, at a temperature of about 180° C. to provide the corresponding compounds of Formula One, wherein R11 is CH2NH(2-pyridine), and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, X1, X2, and X3 are as previously disclosed.
The compounds of Formula One can be further elaborated by standard methods. For example, when R11 contains a thioether, the thioether can be oxidized to the sulfone by treatment with oxone in the presence of an acetone:water mixture at ambient temperature. When R11 contains an oxalate ester, the compound of Formula One can be transformed into the corresponding oxalamide by reaction with an amine hydrochloride and a solution of trimethylaluminum in toluene in a non-reactive solvent such as CH2Cl2.




In Scheme XXVII, a fluorobenzaldehyde of Formula XXIX, wherein R10, X1, X2, and X3 are as previously disclosed can be converted to a (1,2,4-triazol-1-yl)benzaldehyde of Formula XXX, wherein R11 is a substituted or unsubstituted 1,2,4-triazol-1-yl group, and R10, X1, X2, and X3 are as previously disclosed by reaction with a substituted or unsubstituted 1,2,4-triazole in the presence of a base, such as K2CO3, in a solvent such as DMF as in step aj. In step ak, the (1,2,4-triazol-1-yl)benzaldehyde of Formula XXX is converted to a (1,2,4-triazol-1-yl)vinyl benzene of Formula XXXIa wherein R11 is a substituted or unsubstituted 1,2,4-triazol-1-yl group, and R8, R10, X1, X2, and X3 are as previously disclosed by reaction with triphenyl phosphonium bromide in the presence of a base, such as K2CO3, in an aprotic solvent, such as 1,4-dioxane.




In Scheme XXVIII, a bromofluorobenzene of Formula XXXII, wherein R10, X1, X2, and X3 are as previously disclosed can be converted to a (1,2,4-triazol-1-yl)vinylbenzene of Formula XXXIb, wherein R11 is a substituted or unsubstituted 1,2,4-triazol-1-yl group, and R8, R10, X1, X2, and X3 are as previously disclosed in two steps. In step al, the bromofluorobenzene is reacted with a substituted or unsubstituted 1,2,4-triazole in the presence of a base, such as K2CO3, in a solvent such as DMF to generate the (1,2,4-triazol-1-yl)bromobenzene. In step cl, the (1,2,4-triazol-1-yl)bromobenzene is reacted with vinyl boronic anhydride pyridine complex in the presence of a catalyst, such as Pd(PPh3)4, and a base, such as K2CO3 in a solvent such as toluene.




Coupling of the compounds of Formula V with compounds of Formula XXXIa and XXXIb can be accomplished as in Schemes XXIX. In step l, a compound of Formula V, wherein Y is Br, R1, R2, R3, R4, R5, R6, and R7 are as previously disclosed, and a vinylbenzene of Formula XXXIa or XXXIb, wherein R11 is a substituted or unsubstituted 1,2,4-triazol-1-yl group, and R8, R9, R10, X1, X2, and X3 are as previously disclosed, are allowed to react in the presence of CuCl and 2,2-bipyridyl in a solvent, such as 1,2-dichlorobenzene, at a temperature of about 180° C. to provide the molecules of Formula One, wherein R11 is a substituted or unsubstituted 1,2,4-triazol-1-yl group, and R1, R2, R3, R4, R5, R6, R7, R8, R10, X1, X2, and X3 are as previously disclosed.




In Scheme XXX, compounds of Formula XXXIII wherein R11 is a 3-nitro-1,2,4-triazol-1-yl group, and R1, R2, R3, R4, R5, R6, R7, R8, R10, X1, X2, and X3 are as previously disclosed can be converted to compounds of Formula One, wherein R11 is a 3-amido-1,2,4-triazol-1-yl group, and R1, R2, R3, R4, R5, R6, R7, R8, R10, X1, X2, and X3 are as previously disclosed by a two-step process. In step am, the 3-nitro-1,2,4-triazol-1-yl group is reduced to a 3-amino-1,2,4-triazol-1-yl group in the presence of zinc dust and ammonium chloride (NH4Cl) in a protic solvent, such as MeOH. In step an, the 3-amino -1,2,4-triazol-1-yl group is acylated with an acid chloride, such as cyclopropylcarbonyl chloride or acetyl chloride, in the presence of a base, such as TEA, in a solvent such as CH2Cl2.




In step ao of Scheme XXXI, a bromophenyl methyl ketone of Formula XXXIV wherein R10, X1, X2, and X3 are as previously disclosed is converted to an phenyl methyl ketone of the Formula XXXV wherein R11 is a 1,2,4-triazol-1-yl group, and R10, X1, X2, and X3 are as previously disclosed by treatment with 1,2,4-triazole in the presence of a base, such as cesium carbonate (Cs2CO3), and a catalyst, such as copper iodide (CuI), in a solvent, such as DMF. In step ap, the 1,2,4-triazolylacetophenone of Formula XXXV is converted to the trimethylsilyl enol ether of Formula XXXVI by treatment with trimethylsilyl triflluoromethanesulfonate in the presence of a base, such as TEA, in an aprotic solvent, such as CH2Cl2. In step aq, the silyl enol ether is reacted with a compound of Formula V, wherein Y is Br, R1, R2, R3, R4, R5, R6, and R7 are as previously disclosed in the presence of CuCl and 2,2-bipyridyl in a solvent, such as 1,2-dichlorobenzene at a temperature of about 180° C. to generate a ketone of the Formula XXXVII, wherein R11 is a 1,2,4-triazol-1-yl group, and R1, R2, R3, R4, R5, R6, R7, R10, X1, X2, and X3 are as previously disclosed. In step ar, the ketone of the Formula XXXVII is treated with methylmagnesium bromide in an aprotic solvent, such as THF to generate the tertiary alcohol. The tertiary alcohol then undergoes an elimination reaction when treated with a catalytic amount of p-toluenesulfonic acid in a solvent, such as toluene, when heated to a temperature to allow azeotropic removal of water to produce compounds of Formula One wherein R11 is a 1,2,4-triazol-1-yl group, R8 is methyl, and R1, R2, R3, R4, R5, R6, R7, R10, X1, X2, and X3 are as previously disclosed, as in step as.




In Scheme XXXII, a compound of Formula XXXVIII, wherein R10 and R11 together form a linkage, having 3-4 carbon atoms and an oxo substituent and with the ring carbon atoms form a 5- or 6-membered cyclic ring, and R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, and X3 are as previously disclosed is converted to a molecule of Formula One, wherein R10 and R11 together form a linkage, having 3-4 carbon atoms and an alkylamine substituent with the ring carbon atoms form a 5- or 6-membered cyclic ring and R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, and X3 are as previously disclosed, by treatment with an alkylamine, such as 3,3,3-trifluoropropylamine, in the presence of a reducing agent, such as sodium cyanoborohydride (NaBH3CN), in a solvent, such as 1,2-dichloroethane (DCE).




In Scheme XXXIII, a compound of Formula XXXIX, wherein X1, X2, and X3 are as previously disclosed is converted to a molecule of Formula XL, wherein X1, X2, and X3 are as previously disclosed, by treatment with a reducing agent, such as NaBH3CN, in a solvent, such as AcOH, as in step au. In step av, the nitrogen atom is protected with a tert-butyloxycarbonyl (BOC) group by reaction with di-tert-butyl dicarbonate in the presence of a catalyst, such as DMAP, in a solvent, such as acetonitrile (MeCN). The bromide of Formula XL can be converted to the olefin of Formula XLI, wherein R8, X1, X2 and X3 are as previously disclosed, by reaction with potassium vinyl trifluoroborate in the presence of a palladium catalyst, such as PdCl2(dppf), and a base, such as K2CO3, in a polar aprotic solvent such as dimethylsulfoxide (DMSO) at 100° C., as in step aw.




In Scheme XXXIV, a compound of Formula XXXIX, wherein X1, X2, and X3 are as previously disclosed is converted to a molecule of Formula XLII, wherein X1, X2, and X3 are as previously disclosed in two steps. In step ax, the olefin is formed by treatment of the bromide with potassium vinyl trifluoroborate in the presence of a palladium catalyst, such as PdCl2, and a ligand, such as triphenylphosphine, and a base, such as Cs2CO3, in a solvent mixture such as THF/water. In step ay, the nitrogen atom is protected with a BOC group by reaction with di-tert-butyl dicarbonate in the presence of a catalyst, such as DMAP, in a solvent, such as MeCN.




In step l of Scheme XXXV, the compound of Formula V, wherein Y, R1, R2, R3, R4, R5, R6, and R7 are as previously disclosed, and the compounds of Formula XLI or XLII, wherein R8, X1, X2 and X3 are as previously disclosed, are allowed to react in the presence of CuCl and 2,2-bipyridyl in a solvent, such as 1,2-dichlorobenzene, at a temperature of about 150° C. to provide the corresponding compounds of Formula XLIIIa or XLIIIb, wherein R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, and X3 are as previously disclosed.




In Scheme XXXVI, a compound of Formula XLIIIa, wherein R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, and X3 are as previously disclosed is converted to a molecule of Formula XLIV, wherein R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, and X3 are as previously disclosed by treatment with trifluoroacetic acid (TFA), in a solvent such as CH2Cl2, as in step az. Compounds of the Formula XLIV can then be transformed into compounds of the Formula XLV wherein R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, and X3 are as previously disclosed, in two steps. In step ba, the indoline is treated with sodium nitrite (NaNO2), in an acid, such as concentrated HCl, at a temperature around 5° C., to form the nitrosoindole. In step bb, the nitrosoindole is reacted with NH4Cl in the presence of zinc powder in a protic solvent, such as MeOH. In step bc, compounds of the Formula XLV are transformed into compounds of the Formula XLVI, wherein X4 is N(R14)(C(═O)R14) and R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, and X3 are as previously disclosed, by treatment with and acid, such as 3,3,3-trifluoropropanoic acid, PyBOP, and a base, such as DIPEA, in a polar aprotic solvent, such as CH2Cl2.




In Scheme XXXVII, a compound of Formula XLIIIb, wherein R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, and X3 are as previously disclosed is converted to an indole of Formula XLVII, wherein R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, and X3 are as previously disclosed by treatment with TFA, in a solvent such as CH2Cl2, as in step bd. Compounds of the Formula XLVII can be transformed into compounds of the Formula XLVIII wherein R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, and X3 are as previously disclosed, by reaction with 4-nitrophenyl-2-((tert-butoxycarbonyl)amino)acetate in the presence of potassium fluoride (KF) and a crown ether, such as 18-crown-6-ether, in a solvent, such as MeCN, as in step be. Compounds of the Formula XLVIII can be transformed into compounds of the Formula XLIX, wherein R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, and X3 are as previously disclosed in two steps. In step bf, the Boc group is removed by treatment with TFA, in a solvent such as CH2Cl2. In step bg, the amine is treated with 3,3,3-trifluoropropanoic acid, PyBOP, and a base, such as DIPEA, in a polar aprotic solvent, such as CH2Cl2.




In Scheme XXXVIII, a compound of Formula L, wherein X1, X2, and X3 are as previously disclosed is converted to a compound of the Formula LI, wherein X1, X2, and X3 are as previously disclosed by treatment with copper (II) sulfate pentahydrate and Zn powder in a base, such as NaOH as in step bh. Compounds of the Formula LI can be transformed into compounds of the Formula LII wherein X1, X2, and X3 are as previously disclosed, by reaction with hydrazine, in a solvent such as water, at a temperature around 95° C., as in step bi. In step bj, the olefin of the Formula LIII wherein X1, X2, and X3 are as previously disclosed is formed by treatment of the bromide with potassium vinyl trifluoroborate in the presence of a palladium catalyst, such as PdCl2(dppf), and a base, such as K2CO3, in a solvent mixture such as DMSO. Compounds of the Formula LIV, wherein X1, X2, and X3 are as previously disclosed, can be formed from compounds of the Formula LIII by reaction with ethyl bromoacetate, in the presence of a base, such as Cs2CO3, in a solvent, such as DMF.




In step l of Scheme XXXIX, the compound of Formula V, wherein Y, R1, R2, R3, R4, R5, R6, and R7 are as previously disclosed, and the compound of Formula LIV, wherein R8, X1, X2 and X3 are as previously disclosed, are allowed to react in the presence of CuCl and 2,2-bipyridyl in a solvent, such as 1,2-dichlorobenzene, at a temperature of about 180° C. to provide the corresponding compound of Formula LV, wherein R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, and X3 are as previously disclosed. The compound of Formula LV can be further transformed into a compound of the Formula LVI, wherein R1, R2, R3, R4, R5, R6, R7, R8, X1, X2, and X3 are as previously disclosed, in two steps. In step bl, the ester is hydrolyzed to the acid in the presence of HCl and AcOH, at a temperature of about 100° C. In step bm, the acid is treated with an amine, such as 2,2,2-trifluoroethylamine, PyBOP, and a base, such as DIPEA, in a polar aprotic solvent, such as CH2Cl2.




In step bn of Scheme XL, carboxylic acids of the Formula LVII, wherein R11 is C(═O)OH and R8, R10, X1, X2, and X3 are as previously disclosed and compounds of the Formula V, wherein Y is Br and R1, R2, R3, R4, R5, R6, and R7 are as previously disclosed are allowed to react in the presence of CuCl and 2,2-bipyridyl in a solvent, such as N-methyl pyrrolidine, at a temperature of about 150° C. to afford compounds of Formula LVIII, wherein R11 is (C═O)OH and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X1, X2, and X3 are as previously disclosed. Compounds of the Formula LVIII can be further transformed to the corresponding benzamides of Formula LIX, wherein R11 is (C═O)N(R14)(R15), and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X1, X2, and X3 are as previously disclosed, by treatment with an amine, such as 2-amino-N-(2,2,2-trifluoroethyl)acetamide, PyBOP, and a base, such as DIPEA, in a polar aprotic solvent, such as CH2Cl2, as in step bo.




EXAMPLES
The examples are for illustration purposes and are not to be construed as limiting the invention disclosed in this document to only the embodiments disclosed in these examples.
Starting materials, reagents, and solvents that were obtained from commercial sources were used without further purification. Anhydrous solvents were purchased as Sure/SealTM from Aldrich and were used as received. Melting points were obtained on a Thomas Hoover Unimelt capillary melting point apparatus or an OptiMelt Automated Melting Point System from Stanford Research Systems and are uncorrected. Molecules are given their known names, named according to naming programs within ISIS Draw, ChemDraw, or ACD Name Pro. If such programs are unable to name a molecule, the molecule is named using conventional naming rules. 1H NMR spectral data are in ppm (δ) and were recorded at 300, 400, or 600 MHz, and 13C NMR spectral data are in ppm (δ) and were recorded at 75, 100, or 150 MHz, unless otherwise stated.
Example 1
Preparation of 1-(1-Bromo-2,2,2-trifluoroethyl)-3,5-dichlorobenzene (AI1)




Step 1 Method A. 1-(3,5-Dichlorophenyl)-2,2,2-trifluoroethanol (AI2) To a stirred solution of 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethanone (procured from Rieke Metals, UK; 5.0 grams (g), 20.5 millimoles (mmol)) in MeOH (100 milliliters (mL)) at 0° C. were added NaBH4 (3.33 g, 92.5 mL) and 1 N aqueous NaOH solution (10 mL). The reaction mixture was warmed to 25° C. and stirred for 2 hours (h). After the reaction was deemed complete by thin layer chromatography (TLC), saturated aqueous NH4Cl solution was added to the reaction mixture, and the mixture was concentrated under reduced pressure. The residue was diluted with diethyl ether (Et2O) and washed with water (3×50 mL). The organic layer was dried over sodium sulfate (Na2SO4) and concentrated under reduced pressure to afford the title compound as a liquid (4.0 g, 79%): 1H NMR (400 MHz, CDCl3) δ 7.41 (m, 3H), 5.00 (m, 2H), 2.74 (s, 1H); ESIMS m/z 242.97 ([M−H]−).
Step 1 Method B. 1-(3,5-Dichlorophenyl)-2,2,2-trifluoroethanol (AI12) To a stirred solution of 3,5-dichlorobenzaldehyde (10 g, 57 mmol) in THF (250 mL) were added trifluoromethyltrimethylsilane (9.79 g, 69.2 mmol) and a catalytic amount of TBAF. The reaction mixture was stirred at 25° C. for 8 h. After the reaction was deemed complete by TLC, the reaction mixture was diluted with 3 N HCl and then was stirred for 16 h. The reaction mixture was diluted with water and was extracted with ethyl acetate (EtOAc; 3×). The combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure to afford the title compound as a liquid (8.41 g, 60%).
The following compounds were made in accordance with the procedures disclosed in Step 1 Method A of Example 1 above.
2,6-Difluoro-4-(2,2,2-trifluoro-1-hydroxyethyl)benzonitrile




The product was isolated as a brown solid: mp 83-87° C.; 1H NMR (300 MHz, CDCl3) δ 7.26 (d, J=9.0 Hz, 2H), 5.12 (d, J=6.0 Hz, 1H), 3.06 (s, 1H); ESIMS m/z 237.1 ([M+H]+).
1-(3,5-Difluoro-4-methoxyphenyl)-2,2,2-trifluoroethanol




The product was isolated as a pale yellow liquid: 1H NMR (300 MHz, CDCl3) δ 7.06 (d, J=8.4 Hz, 2H), 4.97-4.94 (m, 1H), 4.03 (s, 3H), 2.64 (s, 1H); EIMS m/z 242.1 ([M]+); IR (thinfilm) 3459, 1135 cm−1.
1-(3,4-Dichlorophenyl)-2,2-difluoropropan-1-ol




The product was isolated as a colorless liquid: 1H NMR (300 MHz, DMSO-d6) δ 7.65-7.62 (m, 2H), 7.41 (d, J=8.4 Hz, 1H), 6.49 (d, J=5.1 Hz, 1H), 4.87-4.78 (m, 1H), 1.53 (t, J=18.9 Hz, 3H); EIMS m/z 240.0 ([M]+); IR (thinfilm) 3434, 1131, 801, 512 cm−1.
The following compounds were made in accordance with the procedures disclosed in Step 1 Method B of Example 1 above.
2,2,2-Trifluoro-1-(3,4,5-trichlorophenyl)ethanol (AI3)




The product was isolated as a pale yellow liquid (500 mg, 65%): 1H NMR (400 MHz, CDCl3) δ 7.45 (s, 2H), 5.00 (m, 1H), 2.80 (s, 1H); ESIMS m/z 278 ([M+H]+); IR (thin film) 3420, 1133, 718 cm−1.
1-(3,5-Dichloro-4-fluorophenyl)-2,2,2-trifluoroethanol (AI4)




The product was isolated as a pale yellow liquid (500 mg, 65%): 1H NMR (400 MHz, CDCl3) δ 7.41 (s, 2H), 5.00 (m, 1H), 2.80 (s, 1H); ESIMS m/z 262 ([M+H]+); IR (thin film) 3420, 1133, 718 cm−1.
1-(3,4-Dichlorophenyl)-2,2,2-trifluoroethanol (AI5)




The product was isolated as a pale yellow liquid (500 mg, 65%): 1H NMR (400 MHz, CDCl3) δ 7.60 (s, 1H), 7.51 (m, 1H), 7.35 (m, 1H), 5.01 (m, 1H), 2.60 (s, 1H); EIMS m/z 244 ([M]+).
1-(3,5-Dibromophenyl)-2,2,2-trifluoroethanol




The title molecule was isolated as a colorless liquid: 1H NMR (300 MHz, CDCl3) δ 7.67 (s, 1H), 7.58 (s, 2H), 5.08-5.02 (m, 1H), 4.42 (bs, 1H); EIMS m/z 333.7 ([M]+); IR (thin film) 3417, 2966, 1128, 531 cm−1.
2,2,2-Trifluoro-1-(3-fluoro-5-(trifluoromethyl)phenyl)ethanol




The title molecule was isolated as a clear, colorless oil: 1H NMR (400 MHz, CDCl3) δ 7.56 (s, 1H), 7.45-7.37 (m, 2H), 5.11 (q, J=6.4 Hz, 1H), 3.22 (bs, 1H); 13C NMR (101 MHz, CDCl3) δ 162.42 (d, J=249.5 Hz), 137.46 (d, J=7.8 Hz), 132.89 (qd, J=33.5, 7.9 Hz), 123.67 (q, J=283.8 Hz), 122.92 (q, J=270.68 Hz), 120.10 (t, J=4.1 Hz), 118.13 (d, J =23.0 Hz), 113.94 (dq, J=24.2, 3.9 Hz), 71.57 (q, J=32.4 Hz); EIMS m/z 262 ([M]+).
1-(3-Chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanol




The product was isolated as a white solid (4.98 g, 77%): mp 42-46° C.; 1H NMR (400 MHz, CDCl3) δ 7.83-7.50 (m, 3H), 5.10 (p, J=6.2 Hz, 1H), 2.88 (d, J=4.3 Hz, 1H); 13C NMR (101 MHz, CDCl3) δ 137.12, 135.84, 131.4, 133.03 (q, J=33.3 Hz), 127.15 (q, J=3.8 Hz), 124.50 (q, J=308.0 Hz), 123.45 (q, J=301.8 Hz), 123.04, 72.06 (q, J=32.5 Hz); 19F NMR (376 MHz, CDCl3) δ −62.93, −78.43; EIMS m/z 278 ([M]+).
2,2,2-Trifluoro-1-(4-fluoro-3-(trifluoromethyl)phenyl)ethanol 




The product was isolated as a brown liquid: 1H NMR (400 MHz, CDCl3) δ 7.76 (d, J =6.8 Hz, 1H), 7.69-7.67 (m, 1H), 7.28-7.23 (m, 1H), 5.05-5.02 (m, 1H); ESIMS m/z 261.1 ([M−H]−); IR (thin film) 3418, 1131 cm−1.
2,2,2-Trifluoro-1-(3,4,5-trifluorophenyl)ethanol




The product was isolated as a colorless liquid: 1H NMR (300 MHz, CDCl3) δ 7.19-7.10 (m, 2H), 5.03-4.96 (m, 1H), 2.85 (bs, 1H); EIMS m/z 230.1 ([M]+).
2,2,2-Trifluoro-1-(2,3,4-trifluorophenyl)ethanol




The product was isolated as a clear colorless liquid (4.61 g 66%): 1H NMR (400 MHz, CDCl3) δ 7.23 (qd, J=7.4, 6.1, 4.2 Hz, 1H), 6.93 (tdd, J=9.2, 6.9, 2.2 Hz, 1H), 5.25 (q, J=6.3 Hz, 1H), 3.02-2.74 (m, 1H); 13C NMR (101 MHz, CDCl3) δ 151.79 (ddd, J=254.5, 9.8, 3.4 Hz), 149.52 (ddd, J=253.5, 11.0, 3.5 Hz), 139.67 (dt, J=252.5, 15.3 Hz), 123.68 (q, J=282.2 Hz), 122.48 (dt, J=8.2, 4.1 Hz), 118.95 (dd, J=10.6, 3.6 Hz), 112.73 (dd, J=17.7, 3.9 Hz), 66.58-64.42 (m); 19F NMR (376 MHz, CDCl3) δ −78.95 (d, J=6.2 Hz), −132.02 (dd, J=20.0, 8.2 Hz), −137.89 (m), 159.84 (t, J=20.3 Hz); EIMS m/z 230 ([M]+).
2,2,2-Trifluoro-1-(2,4,5-trichlorophenyl)ethanol




The product was isolated as a white solid (3.37 g, 73%): mp 70-73° C.; 1H NMR (400 MHz, CDCl3) δ 7.63 (d, J=2.5 Hz, 1H), 7.54 (d, J=2.5 Hz, 1H), 5.72-5.57 (m, 1H), 2.85 (d, J=4.8 Hz, 1H); 19F NMR (376 MHz, CDCl3) δ −77.84.
1-(4-Chloro-3-nitrophenyl)-2,2,2-trifluoroethanol




The product was isolated as a yellow oil (6.52 g, 73%): 1H NMR (400 MHz, CDCl3) δ 8.04 (d, J=2.0 Hz, 1H), 7.75-7.51 (m, 2H), 5.16 (m, 1H), 3.41 (d, J=4.3 Hz, 1H); 13C NMR (101 MHz, CDCl3) δ 147.65, 134.44, 132.23, 132.17, 128.11, 124.66, 123.60 (q, J=283.8), 70.99 (q, J=32.6 Hz); 19F NMR (376 MHz, CDCl3) δ −78.47; EIMS m/z 230 ([M]+).
2,2,2-Trifluoro-1-(4-fluoro-3,5-dimethylphenyl)ethanol




The product was isolated as a white solid (6.49 g, 84%): mp 45-49° C.; 1H NMR (400 MHz, CDCl3) δ 7.10 (d, J=6.8 Hz, 2H), 4.89 (m, 1H), 2.63 (d, J=4.3 Hz, 1H), 2.27 (d, J=2.2 Hz, 6H); 13C NMR (101 MHz, CDCl3) δ 160.45 (d, J=246.0 Hz), 128.73, 127.97, 124.92 (d, J=18.6 Hz), 124.19 (q, J=279.1 Hz), 72.36 (q, J=32.0 Hz), 14.61 (d, J=4.1 Hz).
19F NMR (376 MHz, CDCl3) δ −78.48, −120.14; EIMS m/z 222 ([M]+).
2,2,2-Trifluoro-1-(4-fluoro-3-methylphenyl)ethanol




The product was isolated as a white solid (2.12 g, 33%): mp 40-46° C.; 1H NMR (400 MHz, CDCl3) δ 7.28 (d, J=7.4 Hz, 1H), 7.25-7.14 (m, 1H), 7.01 (t, J=8.9 Hz, 1H), 5.05-4.63 (m, 1H), 3.03 (d, J=4.2 Hz, 1H); 13C NMR (101 MHz, CDCl3) δ 161.91 (d, J=247.0 Hz), 130.62 (d, J=5.6 Hz), 129.41 (d, J=3.5 Hz), 126.55 (d, J=8.5 Hz), 115.19 (d, J=22.9 Hz), 72.23 (q, J=32.1 Hz), 14.44 (d, J=3.6 Hz); 19F NMR (376 MHz, CDCl3) δ-78.57, −116.15; EIMS m/z 208 ([M]+).
1-(3-Chloro-4-methylphenyl)-2,2,2-trifluoroethanol




The product was isolated as a clear colorless oil (4.99 g, 75%): 1H NMR (400 MHz, CDCl3) δ 7.31 (s, 1H), 7.10 (m, 2H), 4.79 (q, J=6.1 Hz, 1H), 2.89 (bs, 1H), 2.25 (s, 3H); 13C NMR (101 MHz, CDCl3) δ 137.64, 134.67, 132.99, 131.09, 128.01, 125.58, 124.02 (q, J=284.8 Hz), 72.08 (q, J=32.3 Hz); 19F NMR (376 MHz, CDCl3) δ −78.39; EIMS m/z 224.5 ([M]+).
1-(3,4-Dibromophenyl)-2,2,2-trifluoroethanol




The product was isolated as a clear colorless oil (5.92 g, 88%): 1H NMR (400 MHz, CDCl3) δ 7.76 (d, J=2.0 Hz, 1H), 7.66 (d, J=8.3 Hz, 1H), 7.29 (dd, J=8.3, 2.0 Hz, 1H), 4.99 (qd, J=6.4, 4.2 Hz, 1H), 2.75 (d, J=4.3 Hz, 1H); 13C NMR (101 MHz, CDCl3) δ 134.52, 133.81, 132.60, 127.45, 126.19, 125.16, 123.71 (q, J=283.8 Hz)., 71.57 (q, J=32.5 Hz); 19F NMR (376 MHz, CDCl3) δ −78.44; EIMS m/z 334 ([M]+).
2,2,2-Trifluoro-1-(3-(trifluoromethoxy)phenyl)ethanol




The product was isolated as a clear colorless oil (20.9 g, 79%): 1H NMR (400 MHz, CDCl3) δ 7.55-7.36 (m, 3H), 7.33-7.14 (m, 1H), 5.06 (m, 1H), 2.80 (br m, 1H); 13C NMR (101 MHz, CDCl3) δ 149.36 (q, J=2.0 Hz), 136.04, 129.99, 125.78, 123.91 (q, J=282.8 Hz), 121.90, 120.31 (q, J=258.6 Hz), 120.12, 72.04 (q, J=32.3 Hz); 19F NMR (376 MHz, CDCl3) δ −57.92, −78.49; EIMS m/z 260 ([M]+).
2-Fluoro-5-(2,2,2-trifluoro-1-hydroxyethyl)benzonitrile




The product was isolated as a clear colorless oil (5.47 g, 58%): 1H NMR (400 MHz, CDCl3) δ 7.80 (dd, J=5.9, 2.2 Hz, 1H), 7.76 (ddd, J=7.8, 5.0, 2.3 Hz, 1H), 7.30 (d, J=8.6 Hz, 1H), δ 5.09 (qd, J=6.3, 4.2 Hz, 1H), 3.12 (bm, 1H); 13C NMR (101 MHz, CDCl3) δ 163.49 (d, J=261.7 Hz), 134.23 (d, J=8.6 Hz), 132.67, 131.17, 123.66 (q, J=282.4 Hz), 116.79 (d, J=20.1 Hz), 113.39, 100.96 (d, J=194.9), 71.07 (q, J=32.5 Hz); 19F NMR (376 MHz, CDCl3) δ −78.70, −105.22; EIMS m/z 219 ([M]+).
1-(3-Bromo-5-chlorophenyl)-2,2,2-trifluoroethanol




The product was isolated as a yellow liquid: 1H NMR (300 MHz, DMSO-d6) δ 7.78 (s, 1H), 7.67 (s, 1H), 7.57 (s, 1H), 7.15 (d, J=5.7 Hz, 1H); EIMS m/z 288 ([M]+); IR (thin film) 3435, 1175, 750 cm−1.
1-(3-Bromo-5-fluorophenyl)-2,2,2-trifluoroethanol




The product was isolated as a pale yellow liquid: 1H NMR (400 MHz, CDCl3) δ 7.43 (s, 1H), 7.29-7.26 (m, 1H), 7.18 (d, J=8.8 Hz, 1H), 5.03-4.98 (m, 1H), 3.60 (bs, 1H).; EIMS m/z 272.0 ([M]+); IR (thin film) 3400, 1176, 520 cm−1.
1-(3,5-Dichlorophenyl)-2,2,3,3,3-pentafluoropropan-1-ol




Using pentafluoroethyltrimethylsilane, the product was isolated as a white solid (6.22 g, 88%): mp 71-73° C.; 1H NMR (400 MHz, CDCl3) δ 7.42 (t, J=1.9 Hz, 1H), 7.37 (d, J=1.8 Hz, 2H), 5.11 (dt, J=16.2, 5.7 Hz, 1H), 2.62 (d, J=4.9 Hz, 1H); 13C NMR (101 MHz, CDCl3) δ 136.90, 135.31, 129.84, 126.38, 70.94 (dd, J=28.2, 23.1 Hz); 19F NMR (376 MHz, CDCl3) δ −81.06, −120.94 (d, J=277.5 Hz), −129.18 (d, J=277.5 Hz); EIMS m/z 295 ([M]+).
2,2,3,3,3-Pentafluoro-1-(3,4,5-trichlorophenyl)propan-1-ol




Using pentafluoroethyltrimethylsilane, the product was isolated as an off white semi solid: 1H NMR (300 MHz, DMSO-d6) δ 7.78 (s, 2H), 7.29 (d, J=5.4 Hz,), 5.50-5.40 (m, 1H); EIMS m/z 328.0 ([M]+); IR (thin film) 3459, 1188, 797 cm−1.
2,2,2-Trifluoro-1-(3-(trifluoromethyl)phenyl)ethanol 




The product was isolated as a light yellow (13.8 g, 89%): 1H NMR (400 MHz, CDCl3) δ 7.77 (s, 1H), 7.70-7.67 (m, 2H), 7.55 (t, J=7.8 Hz, 1H), 5.12 (q, J=6.6 Hz, 1H), 2.76 (s, 1H); 19F NMR (376 MHz, CDCl3) δ −62.8, −78.5; EIMS m/z 244 ([M]+).
1-(3,4-Dichloro-5-methylphenyl)-2,2,2-trifluoroethanol




The product was isolated as an off pale yellow solid: 1H NMR (400 MHz, CDCl3) δ 7.44 (s, 1H), 7.26 (s, 1H), 4.98-4.95 (m, 1H), 2.61 (d, J=4.4 Hz, 1H), 2.44 (s, 3H).; EIMS m/z 258.1 ([M]+); IR (thin film) 3421, 2926, 1129, 748 cm−1.
1-(3-Chloro-5-ethylphenyl)-2,2,2-trifluoroethanol




The product was isolated as an off brown liquid (0.43 g, 85%): 1H NMR (300 MHz, DMSO-d6) δ 7.34 (s, 1H), 7.31-7.30 (m, 2H), 6.99 (d, J=5.7 Hz, 1H), 5.23-5.16 (m, 1H), 2.67 (m, 2H), 1.19 (t, J=7.8 Hz, 3H); EIMS m/z 238.0 ([M]+); IR (thin film) 3361, 1172, 749 cm−1.
1-(4-Bromo-3,5-dichlorophenyl)-2,2,2-trifluoroethanol




The product was isolated as a colorless liquid: 1H NMR (300 MHz, DMSO-d6) δ 7.75 (s, 2H), 7.24 (d, J=6.0 Hz, 1H), 5.34-5.29 (m, 1H); EIMS m/z 321.88 ([M]+); IR (thin film) 3420, 1706, 1267, 804, 679 cm−1.
1-(3,5-Dibromo-4-chlorophenyl)-2,2,2-trifluoroethanol 




The product was isolated as a pale yellow gum: 1H NMR (300 MHz, DMSO-d6) δ 7.89 (s, 2H), 7.20 (d, J=6.0 Hz, 1H) 5.34-5.30 (m, 1H); EIMS m/z 366.0 ([M]+).
Step 2. 1-(1-Bromo-2,2,2-trifluoroethyl)-3,5-dichlorobenzene (AI1) To a stirred solution of 1-(3,5-dichlorophenyl)-2,2,2-trifluoroethanol (4.0 g, 16.3 mmol) in CH2Cl2 (50 mL), were added NBS (2.9 g, 16.3 mmol) and triphenyl phosphite (5.06 g, 16.3 mmol), and the resultant reaction mixture was heated at reflux for 18 h. After the reaction was deemed complete by TLC, the reaction mixture was cooled to 25° C. and was concentrated under reduced pressure. Purification by flash column chromatography (SiO2, 100-200 mesh; eluting with 100% pentane) afforded the title compound as a liquid (2.0 g, 40%): 1H NMR (400 MHz, CDCl3) δ 7.41 (s, 3H), 5.00 (m, 1H); EIMS m/z 306 ([M]+).
The following compounds were made in accordance with the procedures disclosed in Step 2 of Example 1.
5-(1-Bromo-2,2,2-trifluoroethyl)-1,2,3-trichlorobenzene (AI6)




The product was isolated as a colorless oil (300 mg, 60%): 1H NMR (400 MHz, CDCl3) δ 7.59 (s, 2H), 5.00 (m, 1H); EIMS m/z 340.00 ([M]+).
5-(1-Bromo-2,2,2-trifluoroethyl)-1,3-dichloro-2-fluorobenzene (AI7)




The product was isolated as a colorless oil (320 mg, 60%): 1H NMR (400 MHz, CDCl3) δ 7.45 (s, 2H), 5.00 (m, 2H); EIMS m/z 324.00 ([M]+).
4-(1-Bromo-2,2,2-trifluoroethyl)-1,2-dichlorobenzene (AI8)




The product was isolated as a colorless oil (300 mg, 60%): 1H NMR (400 MHz, CDCl3) δ 7.63 (s, 1H), 7.51 (m, 1H), 7.35 (m, 1H), 5.01 (m, 1H); EIMS m/z 306.00 ([M]+).
1,3-Dibromo-5-(1-bromo-2,2,2-trifluoroethyl)benzene




The title molecule was isolated as a colorless liquid: 1H NMR (300 MHz, CDCl3) δ 7.71 (s, 1H), 7.59 (s, 2H), 5.04-4.97 (m, 1H); EIMS m/z 394.6 ([M]+); IR (thin film) 1114, 535 cm−1.
1-(1-Bromo-2,2,2-trifluoroethyl)-3-fluoro-5-(trifluoromethyl)benzene




The title molecule was isolated as a colorless liquid: 1H NMR (400 MHz, DMSO-d6) δ 7.90 (d, J=8.4 Hz, 1H), 7.79-7.77 (m, 2H), 6.40-6.34 (m, 1H); EIMS m/z 324.00 ([M]+); IR (thin film) 1175, 525 cm−1.
1-(1-Bromo-2,2,2-trifluoroethyl)-3-chloro-5-(trifluoromethyl)benzene




The title molecule was isolated as a colorless liquid: 1H NMR (400 MHz, CDCl3) δ 7.71 (s, 1H), 7.67 (s, 1H), 7.64 (s, 1H), 5.15-5.09 (m, 1H); EIMS m/z 340.00 ([M]+); IR (thin film) 1178, 750, 540 cm−1.
4-(1-Bromo-2,2,2-trifluoroethyl)-1-fluoro-2-(trifluoromethyl)benzene




The title molecule was isolated as a colorless liquid: 1H NMR (400 MHz, CDCl3) δ 7.75-7.72 (m, 2H), 7.28-7.24 (m, 1H), 5.19-5.16 (m, 1H); EIMS m/z 326.0 ([M]+); IR (thin film) 1114, 571 cm−1.
5-(1-Bromo-2,2,2-trifluoroethyl)-1,2,3-trifluorobenzene 




The title molecule was isolated as a brown liquid: 1H NMR (300 MHz, CDCl3) δ 7.23-7.12 (m, 2H), 5.05-4.98 (m, 1H); EIMS m/z 292.0 ([M]+); IR (thin film) 1116, 505 cm−1.
1-(1-Bromo-2,2,2-trifluoroethyl)-2,3,4-trifluorobenzene




The title molecule was isolated as a colorless oil: 1H NMR (300 MHz, CDCl3) δ 7.44 (qd, J=m, 1H), 7.11-7.03 (m, 1H), 5.53-5.45 (m, 1H).
1-(1-Bromo-2,2,2-trifluoroethyl)-2,4,5-trichlorobenzene




The title molecule was isolated as an off white solid: 1H NMR (300 MHz, DMSO-d6) δ 8.06 (d, J=2.1 Hz, 1H), 7.71 (s, 1H), 6.45-6.37 (m, 1H); EIMS m/z 340.0 ([M]+); IR (thin film) 1186, 764, 576 cm−1.
4-(1-Bromo-2,2,2-trifluoroethyl)-1-chloro-2-nitrobenzene




The title molecule was isolated as an off white solid: 1H NMR (300 MHz, DMSO-d6) δ 8.30 (s, 1H), 7.92 (d, J=9.0 Hz, 1H), 6.43-6.35 (m, 1H); EIMS m/z 317.0 ([M]+); IR (thin film) 2927, 1540, 1353, 1177, 766, 530 cm−1.
5-(1-Bromo-2,2,2-trifluoroethyl)-2-fluoro-1,3-dimethylbenzene




The title molecule was isolated as a colorless liquid: 1H NMR (300 MHz, DMSO-d6) δ 7.32 (d, J=7.2 Hz, 2H), 6.15-6.07 (m, 1H), 3.23 (s, 6H); ESIMS m/z 284.1([M+H]+); IR (thin film) 2962, 1112, 500 cm−1.
4-(1-Bromo-2,2,2-trifluoroethyl)-1-fluoro-2-methylbenzene




The title molecule was isolated as a colorless liquid: 1H NMR (300 MHz, CDCl3) δ 7.34-7.28 (m, 2H), 7.04-6.98 (m, 1H), 5.10-5.03 (m, 1H), 2.29 (s, 3H); EIMS m/z 270.1([M]+); IR (thin film) 2989, 1163 cm−1.
1-(1-Bromo-2,2,3,3,3-pentafluoropropyl)-3,5-dichlorobenzene




The title molecule was isolated as a colorless liquid: 1H NMR (400 MHz, DMSO-d6) δ 7.79 (t, J=2.0 Hz, 1H), 7.63 (S, 2H), 6.37-6.29 (m, 1H); EIMS m/z 356([M]+); IR (thin film) 1673, 1130, 715, 518 cm−1.
4-(1-Bromo-2,2,2-trifluoroethyl)-2-chloro-1-methylbenzene




The title molecule was isolated as a colorless liquid: 1H NMR (300 MHz, CDCl3) δ 7.55-7.50 (m, 2H), 7.44 (d, J=8.4 Hz, 1H), 6.24-6.16 (m, 1H); IR (thin film) 2983, 1112, 749, 564 cm−1.
1,2-Dibromo-4-(1-bromo-2,2,2-trifluoroethyl)benzene




The title molecule was isolated as a colorless liquid: 1H NMR (300 MHz, CDCl3) δ 7.75 (s, 1H), 7.67 (d, J=8.4 Hz, 1H), 7.33-7.30 (m, 1H), 5.07-5.00 (m, 1H); EIMS m/z 393.8 ([M]+); IR (thin film) 2981, 1644, 1165 cm−1.
1-(1-Bromo-2,2,2-trifluoroethyl)-3-(trifluoromethoxy)benzene 




The title molecule was isolated as a colorless liquid: 1H NMR (300 MHz, DMSO-d6) δ 7.65-7.60 (m, 2H), 7.56-7.50 (m, 2H), 6.35-6.27 (m, 1H); EIMS m/z 322 ([M]+); IR (thin film) 3413, 1161, 564 cm−1.
5-(1-Bromo-2,2,2-trifluoroethyl)-2-fluorobenzonitrile




The title molecule was isolated as a pale yellow liquid: 1H NMR (300 MHz, CDCl3) δ 8.15-8.12 (m, 1H), 8.00-7.98 (m, 1H), 7.69-7.63 (m, 1H), 6.31-6.26 (m, 1H); EIMS m/z 280.9 ([M]+).
1-Bromo-3-(1-bromo-2,2,2-trifluoroethyl)-5-chlorobenzene




The title molecule was isolated as a pale yellow liquid: 1H NMR (400 MHz, DMSO-d6) δ 7.90 (s, 1H), 7.74 (s, 1H), 7.65 (s, 1H), 6.26-6.20 (m, 1H); EIMS m/z 349.9 ([M]+); IR (thin film) 1114, 764 cm−1.
1-Bromo-3-(1-bromo-2,2,2-trifluoroethyl)-5-fluorobenzene




The title molecule was isolated as a colorless liquid: 1H NMR (400 MHz, CDCl3) δ 7.43 (s, 1H), 7.32-7.29 (m, 1H), 7.22 (d, J=8.8 Hz, 1H), 1.06 (q, 1H); EIMS m/z 334.0 ([M]+); IR (thin film) 3087, 1168, 533 cm−1.
5-(1-Bromo-2,2,3,3,3-pentafluoropropyl)-1,2,3-trichlorobenzene




The title molecule was isolated as a colorless liquid: 1H NMR (300 MHz, DMSO-d6) δ 7.85 (s, 2H), 6.38-6.29 (m, 1H); EIMS m/z 389.9 ([M]+); IR (thin film) 1208, 798, 560 cm−1.
4-(1-Bromo-2,2,2-trifluoroethyl)-2,6-difluorobenzonitrile




The title molecule was isolated as a purple solid: mp 59-63° C.; 1H NMR (400 MHz, CDCl3) δ 7.25 (s, 2H), 5.11-5.07 (m, 1H); ESIMS m/z 299.0 ([M+H]+).
1-(1-Bromo-2,2,2-trifluoroethyl)-3-(trifluoromethyl)benzene




The title molecule was isolated as a colorless liquid: mp 59-63° C.; 1H NMR (300 MHz, CDCl3) δ 7.75-7.67 (m, 3H), 7.57-7.52 (m, 1H), 5.20-5.13 (m, 1H); ESIMS m/z 306.0 ([M]+); IR (thinfilm) 3436, 2925, 1265, 749 cm−1.
5-(1-Bromo-2,2,2-trifluoroethyl)-1,3-difluoro-2-methoxybenzene




The title molecule was isolated as a pale yellow liquid: 1H NMR (400 MHz, CDCl3) δ 7.08 (d, J=8.4 Hz, 2H), 5.03-4.98 (m, 1H), 4.04 (s, 3H); ESIMS m/z 304.1 ([M+H]+); IR (thinfilm) 1114, 613 cm−1.
5-(1-Bromo-2,2,2-trifluoroethyl)-1,2-dichloro-3-methylbenzene




The title molecule was isolated as a colorless liquid: 1H NMR (400 MHz, CDCl3) δ 7.46 (s, 1H), 7.27 (s, 1H), 5.04-4.99 (m, 1H), 2.44 (s, 3H); EIMS m/z 320.0 ([M]+); IR (thinfilm) 2925, 1112, 752, 580 cm−1.
4-(1-Bromo-2,2-difluoropropyl)-1,2-dichlorobenzene 




The title molecule was isolated as a colorless liquid: 1H NMR (300 MHz, DMSO-d6) δ 7.76-7.70 (m, 2H), 7.54 (dd, J=8.4 1.8 Hz, 1H), 5.81-5.73 (m, 1H), 1.67 (d, J=18.9 Hz, 3H); EIMS m/z 304.0 ([M]+); IR (thinfilm) 1118, 800, 499 cm−1.
1-(1-Bromo-2,2,2-trifluoroethyl)-3-chloro-5-ethylbenzene




The title molecule was isolated as a colorless liquid: 1H NMR (400 MHz, DMSO-d6) δ 7.43 (d, J=5.6 Hz, 2H), 7.39 (s, 1H), 6.20-6.16 (m, 1H), 2.68-2.62 (m, 2H), 1.19 (t, J=7.6 Hz, 3H); EIMS m/z 300.0 ([M]+); IR (thinfilm) 2970, 1167, 716, 539 cm−1.
2-Bromo-5-(1-bromo-2,2,2-trifluoroethyl)-1,3-dichlorobenzene




The title molecule was isolated as a colorless liquid: 1H NMR (400 MHz, DMSO-d6) δ 7.79 (s, 2H), 6.27-6.21 (m, 1H); EIMS m/z 383.9 ([M]+); IR (thinfilm) 2924, 1114, 749, 534 cm−1.
1,3-Dibromo-5-(1-bromo-2,2,2-trifluoroethyl)-2-chlorobenzene




The title molecule was isolated as a pale yellow liquid: 1H NMR (300 MHz, DMSO-d6) δ 7.97 (s, 2H), 6.27-6.19 (m, 1H); EIMS m/z 428.0 ([M]+).
Example 2
Preparation of N-Methyl-4-vinylbenzamide (AI9)




Step 1. 4-Vinylbenzoyl chloride (AI10) To a stirred solution of 4-vinylbenzoic acid (1 g, 6.75 mmol) in CH2Cl2 (20 mL) at 0° C. were added a catalytic amount of DMF and oxalyl chloride (1.27 g, 10.12 mmol) dropwise over a period of 15 minutes (min). The reaction mixture was stirred at 25° C. for 6 h. After the reaction was deemed complete by TLC, the reaction mixture was concentrated under reduced pressure to give the crude acid chloride.
Step 2. N-Methyl-4-vinylbenzamide (AI9) To 1 M N-methylamine in THF (13.5 mL, 13.5 mmol) at 0° C. were added TEA (1.34 mL, 10.12 mmol) and the acid chloride from Step 1 above in THF (10 mL), and the reaction mixture was stirred at 25° C. for 3 h. After the reaction was deemed complete by TLC, the reaction mixture was quenched with water and then was extracted with EtOAc (3×). The combined EtOAc layer was washed with brine and dried over Na2SO4 and concentrated under reduced pressure to afford the title compound as an off-white solid (650 mg, 60%): 1H NMR (400 MHz, CDCl3) δ 7.76 (d, J=8.0 Hz, 2H), 7.45 (d, J=8.0 Hz, 2H), 6.79 (m, 1H), 6.20 (br s, 1H), 5.82 (d, J=17.6 Hz, 1H), 5.39 (d, J=10.8 Hz, 1H); ESIMS m/z 161.95 ([M+H]+).
The following compounds were made in accordance with the procedures disclosed in accordance with Example 2.
N,N-Dimethyl-4-vinylbenzamide (AI11)




The product was isolated as an off-white solid (650 mg, 60%): 1H NMR (400 MHz, CDCl3) δ 7.42 (m, 4H), 6.71 (m, 1H), 5.80 (d, J=17.6 Hz, 1H), 5.31 (d, J=10.8 Hz, 1H), 3.05 (s, 3H), 3.00 (s, 3H); ESIMS m/z 176.01 ([M+H]+).
N-(2,2,3-Trifluoromethyl)-4-vinylbenzamide (AI12)




The product was isolated as an off-white solid (900 mg, 60%): 1H NMR (400 MHz, CDCl3) δ 7.76 (d, J=8.0 Hz, 2H), 7.45 (d, J=8.0 Hz, 2H), 6.79 (m, 1H), 6.20 (br s, 1H), 5.82 (d, J=17.6 Hz, 1H), 5.39 (d, J=10.8 Hz, 1H), 4.19 (m, 2H); ESIMS m/z 230.06 ([M+H]+).
Morpholino(4-vinylphenyl)methanone (AI13) 




The product was isolated as a white solid (850 mg, 60%): ESIMS m/z 218.12 ([M+H]+).
Example 3
Preparation of Ethyl 2-methyl-4-vinylbenzoate (AI14)




Step 1. 4-Formyl-2-methylbenzoic acid (AI15) To a stirred solution of 4-bromo-2-methylbenzoic acid (10 g, 46.4 mmol) in dry THF (360 mL) at −78° C. was added n-BuLi (1.6 M solution in hexanes; 58.17 mL, 93.0 mmol) and DMF (8 mL). The reaction mixture was stirred at −78° C. for 1 h then was warmed to 25° C. and stirred for 1 h. The reaction mixture was quenched with 1 N HCl solution and extracted with EtOAc. The combined EtOAc extracts were washed with brine and dried over Na2SO4 and concentrated under reduced pressure. The residue was washed with n-hexane to afford the title compound as a solid (3.0 g, 40%): mp 196-198° C.; 1H NMR (400 MHz, DMSO-d6) δ 13.32 (br s, 1H), 10.05 (s, 1H), 7.98 (m, 1H), 7.84 (m, 2H), 2.61 (s, 3H); ESIMS m/z 163.00 ([M−H]−).
Step 2. Ethyl 4-formyl-2-methylbenzoate (AI16) To a stirred solution of 4-formyl -2-methylbenzoic acid (3 g, 18.2 mmol) in EtOH (30 mL) was added H2SO4 and the reaction mixture was heated at 80° C. for 18 h. The reaction mixture was cooled to 25° C. and concentrated under reduced pressure. The residue was diluted with EtOAc and washed with water. The combined EtOAc extracts were washed with brine, dried over Na2SO4 and concentrated under reduced pressure to afford the title compound as a solid (2.8 g, 80%): 1H NMR (400 MHz, CDCl3) δ 10.05 (s, 1H), 8.04 (m, 1H), 7.75 (m, 2H), 4.43 (m, 2H), 2.65 (s, 3H), 1.42 (m, 3H).
Step 3. Ethyl 2-methyl-4-vinylbenzoate (AI14) To a stirred solution of ethyl 4-formyl-2-methylbenzoate (2.8 g, 4 mmol) in 1,4-dioxane (20 mL) were added K2CO3 (3.01 g, 21.87 mmol) and methyltriphenyl phosphonium bromide (7.8 g, 21.87 mmol) at 25° C. Then the reaction mixture was heated at 100° C. for 18 h. After the reaction was deemed complete by TLC, the reaction mixture was cooled to 25° C. and filtered, and the filtrate was concentrated under reduced pressure. The crude compound was purified by flash chromatography (SiO2, 100-200 mesh; eluting with 25-30% EtOAc in n-Hexane) to afford the title compound as a solid (2.0 g, 72%): 1H NMR (400 MHz, CDCl3) δ 7.86 (m, 1H), 7.27 (m, 2H), 6.68 (dd, J=17.6, 10.8 Hz, 1H), 5.84 (d, J=17.6 Hz, 1H), 5.39 (d, J=10.8 Hz, 1H), 4.39 (m, 2H), 2.60 (s, 3H), 1.40 (m, 3H); ESIMS m/z 191.10 ([M−H]−); IR (thin film) 2980, 1716, 1257 cm−1.
Example 4
Preparation of tert-Butyl 2-chloro-4-vinylbenzoate (AI17)




Step 1. tert-Butyl 4-bromo-2-chlorobenzoate (AI18) To a stirred solution of 4-bromo-2-chlorobenzoic acid (5 g, 21.37 mmol) in THF (30 mL) was added di-tert-butyl dicarbonate (25.5 g, 25.58 mmol), TEA (3.2 g, 31.98 mmol) and DMAP (0.78 g, 6.398 mmol), and the reaction mixture was stirred at 25° C. for 18 h. The reaction mixture was diluted with EtOAc and washed with water. The combined organic layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by flash chromatography (SiO2, 100-200 mesh; eluting with 2-3% EtOAc in n-hexane) to afford the title compound as a liquid (3.2 g, 51%): 1H NMR (400 MHz, CDCl3) δ 7.62 (m, 2H), 7.44 (d, J=8.4 Hz, 1H), 1.59 (s, 9H); ESIMS m/z 290.10 ([M+H]+); IR(thin film) 1728 cm−1.
The following compounds were made in accordance with the procedures disclosed in Step 1 of Example 4.
tert-Butyl 2-bromo-4-iodobenzoate (AI19)




The product was isolated as a colorless oil (1.2 g, 50%): 1H NMR (400 MHz, CDCl3) δ 8.01 (s, 1H), 7.68 (d, J=8.4 Hz, 1H), 7.41 (d, J=8.0 Hz, 1H), 1.59 (s, 9H); ESIMS m/z 382.10 ([M+H]+); IR(thin film) 1727 cm−1.
tert-Butyl 4-bromo-2-(trifluoromethyl)benzoate(AI20)




The product was isolated as a colorless oil (1 g, 52%): 1H NMR (400 MHz, CDCl3) δ 7.85 (s, 1H), 7.73 (d, J=8.4 Hz, 1H), 7.62 (d, J=8.4 Hz, 1H), 1.57 (s, 9H); ESIMS m/z 324.10 ([M+H]+); IR (thin film) 1725 cm−1.
Step 2. tert-Butyl 2-chloro-4-vinylbenzoate (AI17) To a stirred solution of tert-butyl 4-bromo-2-chlorobenzoate (1.6 g, 5.50 mmol) in toluene (20 mL) was added Pd(PPh3)4 (0.31 mg, 0.27 mmol), K2CO3 (2.27 g, 16.5 mmol) and vinylboronic anhydride pyridine complex (2.0 g, 8.3 mmol) and the reaction mixture was heated to reflux for 16 h. The reaction mixture was filtered, and the filtrate was washed with water and brine, dried over Na2SO4 and concentrated under reduced pressure. Purification by flash column chromatography (SiO2, 100-200 mesh; eluting with 5-6% EtOAc in n-hexane) afforded the title compound as a liquid (0.6 g, 46%): 1H NMR (400 MHz, CDCl3) δ 7.72 (d, J=8.1 Hz, 1H), 7.44 (m, 1H), 7.31 (d, J=8.0 Hz, 1H), 6.69 (dd, J=17.6, 10.8 Hz, 1H), 5.85 (d, J=17.6 Hz, 1H), 5.40 (d, J=10.8 Hz, 1H), 1.60 (s, 9H); ESIMS m/z 238.95 ([M+H]+); IR (thin film) 2931, 1725, 1134 cm−1.
The following compounds were made in accordance with the procedures disclosed in Step 2 of Example 4.
tert-Butyl 2-bromo-4-vinylbenzoate (AI21)




The product was isolated as a colorless oil (1 g, 52%): 1H NMR (400 MHz, CDCl3) δ 7.68 (m, 2H), 7.36 (d, J=8.0 Hz, 1H), 6.68 (dd, J=17.6, 10.8 Hz, 1H), 5.84 (d, J=17.6 Hz, 1H), 5.39 (d, J=10.8 Hz, 1H), 1.60 (s, 9H); ESIMS m/z 282.10 ([M+H]+); IR (thin film) 2978, 1724, 1130 cm−1.
tert-Butyl 2-(trifluoromethyl)-4-vinylbenzoate (AI22)




The product was isolated as a colorless oil (1.2 g, 50%): 1H NMR (400 MHz, CDCl3) δ 7.71 (d, J=6.4 Hz, 2H), 7.59 (d, J=7.6 Hz, 1H), 6.77 (dd, J=17.6, 10.8 Hz, 1H), 5.89 (d, J=17.6 Hz, 1H), 5.44 (d, J=10.8 Hz, 1H), 1.58 (s, 9H); ESIMS m/z 272.20 ([M+H]+); IR (thin film) 2982, 1727, 1159 cm−1.
Example 5
Preparation of tert-Butyl 2-cyano-4-vinylbenzoate (AI23)




To a stirred solution of tert-butyl 2-bromo-4-vinylbenzoate (0.5 g, 1.77 mmol) in DMF (20 mL) was added CuCN (0.23 g, 2.65 mmol), and the reaction mixture was heated at 140° C. for 3 h. The reaction mixture was cooled to 25° C., diluted with water, and extracted with EtOAc. The combined organic layer was washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The residue was purified by flash chromatography (SiO2, 100-200 mesh; eluting with 15% EtOAc in n-hexane) to afford the title compound as a white solid (0.3 g, 72%): mp 51-53° C.; 1H NMR (400 MHz, CDCl3) δ 8.03 (s, 1H), 7.77 (s, 1H), 7.64 (d, J=8.4 Hz, 1H), 6.75 (dd, J=17.6, 10.8 Hz, 1H), 5.93 (d, J=17.6 Hz, 1H), 5.51 (d, J=10.8 Hz, 1H), 1.65 (s, 9H); ESIMS m/z 229.84 ([M+H]+); IR (thin film) 2370, 1709, 1142 cm−1.
Example 6
Preparation of Ethyl 2-bromo-4-iodobenzoate (AI46)




To a stirred solution of 4-iodo-2-bromobenzoic acid (5 g, 15.29 mmol) in EtOH (100 mL) was added H2SO4 (5 mL), and the reaction mixture was heated at 80° C. for 18 h. The reaction mixture was cooled to 25° C. and concentrated under reduced pressure. The residue was diluted with EtOAc (2×100 mL) and washed with water (100 mL). The combined EtOAc extracts were washed with brine, dried over Na2SO4 and concentrated under reduced pressure to afford the compound as a pale yellow solid (5 g, 92%): 1H NMR (400 MHz, DMSO-d6) δ 8.04 (d, J=1.2 Hz, 1H), 7.71 (d, J=7.6 Hz, 1H), 7.51 (d, J=8.4 Hz, 1H), 4.41 (q, J=7.2 Hz, 2H), 1.41 (t, J=7.2 Hz, 3H).
The following compounds were made in accordance with the procedures disclosed in Example 6.
Ethyl 4-bromo-2-chlorobenzoate (AI47)




The title compound was isolated as an off-white solid (2.0 g, 80%): 1H NMR (400 MHz, DMSO-d6) δ 8.25 (d, J=1.2 Hz, 1H), 7.79 (d, J=7.6 Hz, 1H), 7.65 (d, J=8.4 Hz, 1H), 4.65 (q, J=7.2 Hz, 2H), 1.56 (t, J=7.2 Hz, 3H).
Ethyl 4-bromo-2-methylbenzoate (AI48) 




The title compound was isolated as a pale yellow liquid (3.0 g, 83%): 1H NMR (400 MHz, CDCl3) δ 7.79 (d, J=8.4 Hz, 1H), 7.41 (s, 1H), 7.39 (d, J=8.4 Hz, 1H), 4.42 (q, J=7.2 Hz, 2H), 2.60 (s, 3H), 1.40 (t, J=7.2 Hz, 3H)ESIMS m/z 229.11 ([M+H]+); IR (thin film) 1725 cm−1.
Ethyl 4-bromo-2-fluorolbenzoate (AI49)




The title compound was isolated as a colorless liquid (9.0 g, 79%): 1H NMR (400 MHz, DMSO-d6) δ 7.84 (t, J=8.4 Hz, 1H), 7.76 (d, J=2.0 Hz, 1H), 7.58 (d, J=1.6 Hz, 1H), 4.34 (q, J=7.2 Hz, 2H), 1.32 (t, J=7.2 Hz, 3H); ESIMS m/z 246.99 ([M+H]+), IR (thin film) 1734 cm−1.
Example 7
Preparation of Ethyl 4-bromo-2-ethylbenzoate (AI50)




To a stirred solution of 4-bromo-2-fluorobenzoic acid (2.0 g, 9.17 mmol) in THF (16 mL), was added 1.0 M ethyl magnesium bromide in THF (32 mL, 32.0 mmol) dropwise at 0° C. and the resultant reaction mixture was stirred at ambient temperature for 18 h. The reaction mixture was quenched with 2 N HCl and extracted with EtOAc. The combined EtOAc layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford crude 4-bromo-2-ethylbenzoic acid as a colorless liquid that was used in the next step without purification (0.4 g): 1H NMR (400 MHz, CDCl3) δ 7.64 (d, J=8.4 Hz, 1H), 7.47 (m, 1H), 7.43 (m, 1H), 2.95 (q, J=4.0 Hz, 2H), 1.32 (t, J=4.0 Hz, 3H); ESIMS m/z 228.97 ([M+H]+).
The title compound was synthesized from 4-bromo-2-ethylbenzoic acid in accordance to the procedure in Example 6, isolated as a colorless liquid (0.15 g, 68%): 1H NMR (400 MHz, DMSO-d6) δ 7.90 (d, J=8.4 Hz, 1H), 7.47 (m, 2H), 4.40 (q, J=7.2 Hz, 2H), 3.06 (q, J =7.6 Hz, 2H), 1.42 (t, J=7.2 Hz, 3H), 1.26 (t, J=7.6 Hz, 3H); ESIMS m/z 226.96 ([M−H]−); IR (thin film) 3443, 1686, 568 cm−1.
Example 8
Preparation of Ethyl 2-bromo-4-vinylbenzoate (AI51)




To a stirred solution of ethyl 2-bromo-4-iodobenzoate (5 g, 14.3 mmol) in THF/water (100 mL, 9:1) was added potassium vinyltrifluoroborate (1.89 g, 14.3 mmol), Cs2CO3 (18.27 g, 56.07 mmol) and triphenylphosphine (0.22 g, 0.85 mmol) and the reaction mixture was degassed with argon for 20 min, then charged with PdCl2 (0.05 g, 0.28 mmol). The reaction mixture was heated to reflux for 16 h. The reaction mixture was cooled to ambient temperature and filtered through a Celite® bed and washed with EtOAc. The filtrate was again extracted with EtOAc and the combined organic layers washed with water and brine, dried over Na2SO4 and concentrated under reduced pressure to afford crude compound. The crude compound was purified by column chromatography (SiO2, 100-200 mesh; eluting with 2% EtOAc/petroleum ether) to afford the title compound as a light brown gummy material (2 g, 56%): 1H NMR (400 MHz, CDCl3) δ 7.78 (d, J=8.4 Hz, 1H), 7.71 (d, J=1.2 Hz, 1H), 7.51 (d, J=8.4 Hz, 1H), 6.69 (dd, J=17.6, 10.8 Hz, 1H), 5.86 (d, J=17.6 Hz, 1H), 5.42 (d, J=11.2 Hz, 1H), 4.42 (q, J=7.2 Hz, 2H), 1.43 (t, J=3.6 Hz, 3H); ESIMS m/z 255.18 ([M+H]+); IR (thin film) 1729 cm−1.
The following compounds were made in accordance with the procedures disclosed in Example 8.
Ethyl 2-methyl-4-vinylbenzoate (AI52)




The title compound was isolated as a colorless liquid (0.8 g, 80%): 1H NMR (400 MHz, CDCl3) δ 7.89 (d, J=8.4 Hz, 1H), 7.27 (m, 2H), 6.79 (dd, J=17.6, 10.8 Hz, 1H), 5.86 (d, J=17.6 Hz, 1H), 5.42 (d, J=11.2 Hz, 1H), 4.42 (q, J=7.2 Hz, 2H), 2.60 (s, 3H), 1.43 (t, J=7.2 Hz, 3H); ESIMS m/z 191.10 ([M+H]+); IR (thin film) 1717, 1257 cm−1.
Ethyl 2-fluoro-4-vinylbenzoate (AI53)




The title compound was isolated as a pale yellow liquid (2.0 g, 50%): 1H NMR (400 MHz, DMSO-d6) δ 7.87 (t, J=8.0 Hz, 1H), 7.51 (d, J=16.0 Hz, 1H), 7.48 (d, J=16.0 Hz, 1H), 6.82 (dd, J=17.6, 10.8 Hz, 1H), 6.09 (d, J=17.6 Hz, 1H), 5.50 (d, J=10.8 Hz, 1H), 4.35 (q, J=7.2 Hz, 2H), 1.35 (t, J=7.2 Hz, 3H); ESIMS m/z 195.19 ([M+H]+); IR (thin film) 1728 cm−1.
Example 9
Preparation of Ethyl 2-chloro-4-vinylbenzoate (AI54)




To a stirred solution of ethyl 2-chloro-4-bromobenzoate (2 g, 7.63 mmol) in DMSO (20 mL) was added potassium vinyltrifluoroborate (3.06 g, 22.9 mmol) and K2CO3 (3.16 g, 22.9 mmol). The reaction mixture was degassed with argon for 30 min Bistriphenylphosphine(diphenylphosphinoferrocene)palladium dichloride (0.27 g, 0.38 mmol) was added and the reaction mixture was heated to 80° C. for 1 h. The reaction mixture was diluted with water (100 mL), extracted with EtOAc (2×50 mL), washed with brine, dried over Na2SO4 and concentrated under reduced pressure to obtain the compound as brown gummy material (1.1 g, 69%): 1H NMR (400 MHz, CDCl3) δ 7.81 (d, J=8.4 Hz, 1H), 7.46 (s, 1H), 7.33 (d, J=8.4 Hz, 1H), 6.70 (dd, J=17.6, 11.2 Hz, 1H), 5.87 (d, J=17.6 Hz, 1H), 5.42 (d, J=10.8 Hz, 1H), 4.41 (q, J=7.2 Hz, 2H), 1.43 (t, J=7.2 Hz, 3H); ESIMS m/z 211.22 ([M+H]+); IR (thin film) 1729, 886 cm−1.
The following compounds were made in accordance with the procedures disclosed in Example 9.
Ethyl 2-ethyl-4-vinylbenzoate (AI55)




The title compound was isolated as a color less liquid (1.0 g, 66%): 1H NMR (300 MHz, CDCl3) δ 7.85 (m, 1H), 7.29 (m, 2H), 6.76 (d, J=10.8 Hz, 1H), 5.86 (d, J=17.6 Hz, 1H), 5.36 (d, J=10.5 Hz, 1H), 4.41 (q, J=7.2 Hz, 2H), 3.10 (q, J=7.2 Hz, 2H), 1.40 (t, J=7.2 Hz, 3H), 1.30 (t, J=7.2 Hz, 3H); ESIMS m/z 205.26 ([M+H]+); IR (thin film) 1720, 1607, 1263 cm−1.
Methyl 2-methoxy-4-vinylbenzoate (AI56) 




The title compound was isolated as a pale yellow liquid (1.2 g, 75%): 1H NMR (400 MHz, CDCl3) δ 7.79 (d, J=8.0 Hz, 1H), 7.04 (d, J=1.2 Hz, 1H), 6.97 (s, 1H), 6.74 (dd, J=11.2, 11.2 Hz, 1H), 5.86 (d, J=17.6 Hz, 1H), 5.39 (d, J=17.6 Hz, 1H) 3.93 (s, 3H), 3.91 (s, 3H); ESIMS m/z 193.18 ([M+H]+); IR (thin film) 1732 cm−1 
Ethyl 2-(methylthio)-4-vinylbenzoate




The title compound was isolated as a brown liquid: 1H NMR (300 MHz, CDCl3) δ 7.98 (d, J=8.4 Hz, 1H), 7.23-7.18 (m, 2H), 6.78 (dd, J=17.7, 10.8, Hz, 1H), 5.89 (d, J=17.4 Hz, 1H), 5.42 (d, J=10.8 Hz, 1H), 4.39-4.36 (m, 2H), 2.48 (s, 3H), 1.39 (t, J=6.9 Hz, 3H); ESIMS m/z 221.9 ([M+H]+); IR (thin film) 1708 cm−1 
Example 10
Preparation of (E)-Ethyl 4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-enyl)-2-methylbenzoate (AI24)




To a stirred solution of ethyl 2-methyl-4-vinylbenzoate (2.0 g, 10.5 mmol) in 1,2-dichlorobenzene (25 mL) were added 1-(1-bromo-2,2,2-trifluoroethyl)-3,5-dichlorobenzene (6.44 g, 21.0 mmol), CuCl (208 mg, 21 mmol) and 2,2bipyridyl (0.65 g, 4.1 mmol). The reaction mixture was degassed with argon for 30 min and then stirred at 180° C. for 24 h. After the reaction was deemed complete by TLC, the reaction mixture was cooled to 25° C. and filtered, and the filtrate was concentrated under reduced pressure. Purification by flash chromatography (SiO2, 100-200 mesh; eluting with 25-30% EtOAc in petroleum ether) afforded the title compound as a solid (1.7 g, 40%): 1H NMR (400 MHz, CDCl3) δ 7.91 (d, J =8.0 Hz, 1H), 7.37 (m, 1H), 7.27-7.24 (m, 4H), 6.59 (d, J=16.0 Hz, 1H), 6.59 (dd, J=16.0, 8.0 Hz, 1H), 4.38 (q, J=7.2 Hz, 2H), 4.08 (m, 1H), 2.62 (s, 3H), 1.42 (t, J=7.2 Hz, 3H); ESIMS m/z 415.06 ([M−H]−); IR (thin film) 1717, 1255, 1114 cm−1.
Compounds AI25, AI57-AI68 and AC1-AC5 (Table 1) were made in accordance with the procedures disclosed in Example 10.
(E)-Ethyl 4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-2-(trifluoromethyl)-benzoic acid (AI25)




The product was isolated as a pale brown gummy liquid (500 mg, 40%): 1H NMR (400 MHz, CDCl3) δ 7.79 (d, J=8.0 Hz, 1H), 7.71 (m, 1H), 7.61 (d, J=7.6 Hz, 1H), 7.42 (s, 2H), 6.70 (d, J=16.0 Hz, 1H), 6.57 (dd, J=16.0, 8.0 Hz, 1H), 4.42 (q, J=7.2 Hz, 2H), 4.19 (m, 1H), 1.40 (t, J=7.6 Hz, 3H),; ESIMS m/z 502.99 ([M−H]−); IR (thin film) 1730, 1201, 1120, 749 cm−1.
(E)-Ethyl 4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-enyl)-2-fluorobenzoate (AI57)




1H NMR (400 MHz, CDCl3) δ 7.38 (s, 1H), 7.26 (s, 3H), 7.21 (d, J=8.4 Hz, 1H), 7.16 (d, J=11.6 Hz, 1H), 6.59 (d, J=16.0 Hz, 1H), 6.47 (dd, J=, 16.0, 8.0 Hz, 1H), 4.41 (q, J=6.8 Hz, 2H), 4.18 (m, 1H), 1.41 (t, J=6.8 Hz, 3H); ESIMS m/z 419.33 ([M−H]−); IR (thin film) 1723, 1115, 802 cm−1.
(E)-Ethyl 4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-enyl)-2-bromobenzoate (AI58)




1H NMR (400 MHz, CDCl3) δ 7.79 (d, J=8.0 Hz, 1H), 7.67 (s, 1H), 7.38 (m, 2H), 7.26 (m, 2H), 6.56 (d, J=16.0 Hz, 1H), 6.45 (dd, J=16.0, 7.6 Hz, 1H), 4.42 (q, J=7.2 Hz, 2H), 4.39 (m, 1H), 1.42 (t, J=7.2 Hz, 3H); ESIMS m/z 481.22 ([M−H]−); IR (thin film) 1727, 1114, 801, 685 cm−1.
(E)-Ethyl 2-bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzoate (AI59) 




1H NMR (400 MHz, CDCl3) δ 7.79 (d, J=8.0 Hz, 1H), 7.67 (d, J=1.6 Hz, 1H), 7.40 (s, 2H), 7.36 (d, J=1.6 Hz, 1H), 6.56 (d, J=16.0 Hz, 1H), 6.44 (dd, J=16.0, 7.6 Hz, 1H), 4.42 (q, J=6.8 Hz, 2H), 4.15 (m, 1H), 1.42 (t, J=6.8 Hz, 3H); ESIMS m/z 514.74 ([M−H]−); IR (thin film) 1726, 1115, 808, 620 cm−1.
(E)-Ethyl 2-methyl-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzoate (AI60)




The title compound was isolated as a light brown gummy material: 1H NMR (400 MHz, CDCl3) δ 7.90 (d, J=8.8 Hz, 1H), 7.34 (d, J=6.0 Hz, 2H), 7.25 (d, J=7.2 Hz, 2H), 6.59 (d, J=16.0 Hz, 1H), 6.42 (dd, J=16.0, 8.0 Hz, 1H), 4.38 (q, J=7.2 Hz, 2H), 4.19 (m, 1H), 2.63 (s, 3H), 1.41 (t, J=7.2 Hz, 3H).
(E)-Ethyl 2-chloro-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzoate (AI61)




1H NMR (400 MHz, CDCl3) δ 7.87 (d, J=8.0 Hz, 1H), 7.46 (d, J=1.6 Hz, 1H), 7.40 (s, 2H), 7.31 (d, J=1.6 Hz, 1H), 6.57 (d, J=16.0 Hz, 1H), 6.44 (dd, J=16.0 Hz, 8.0 Hz, 1H), 4.42 (q, J=6.8 Hz, 2H), 4.15 (m, 1H), 1.42 (t, J=6.8 Hz, 3H); ESIMS m/z 470.73 ([M−H]−); IR (thin film) 1726, 1115, 809, 3072 cm−1.
(E)-Ethyl 4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-2-(trifluoromethyl)benzoate (AI62)




The title compound was isolated as a pale brown liquid (1.0 g, 46.3%): 1H NMR (400 MHz, CDCl3) δ 7.79 (d, J=8.0 Hz, 1H), 7.71 (s, 1H), 7.61 (d, J=7.6 Hz, 1H), 7.41 (s, 2H) 6.65 (d, J=16.0 Hz, 1H), 6.49 (dd, J=16.0, 8.0 Hz, 1H), 4.42 (q, J=7.6 Hz, 2H), 4.15 (m, 1H), 1.42 (t, J=7.6 Hz, 3H); ESIMS m/z 502.99 ([M−H]−); IR (thin film) 1730, 1202, 1120, 750 cm−1.
(E)-Ethyl 2-chloro-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)benzoate (AI63)




1H NMR (400 MHz, CDCl3) δ 7.85 (d, J=6.0 Hz, 1H), 7.46 (d, J=1.8 Hz, 2H), 7.34 (m, 1H), 7.24 (m, 1H), 6.57 (d, J=16.2 Hz, 1H), 6.45 (dd, J=16.2, 7.2 Hz, 1H), 4.43 (q, J=7.2 Hz, 2H), 4.13 (m, 1H), 1.41 (t, J=7.2 Hz, 3H); ESIMS m/z 455.0 ([M+H]+); IR (thin film) 1728, 1115, 817 cm−1.
(E)-Ethyl 2-fluoro-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)benzoate (AI64)




1H NMR (400 MHz, CDCl3) δ 7.93 (t, J=7.6 Hz, 1H), 7.34 (d, J=5.6 Hz, 2H), 7.21 (d, J=8.0 Hz, 1H), 7.16 (d, J=11.6 Hz, 1H), 6.59 (d, J=16.0 Hz, 1H), 6.49 (dd, J=16.0, 7.6 Hz, 1H), 4.42 (q, J=7.6 Hz, 2H), 4.13 (m, 1H), 1.41 (t, J=7.6 Hz, 3H); ESIMS m/z 436.81 ([M−H]−); IR (thin film) 1725 cm−1.
(E)-Ethyl 2-bromo-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)benzoate (AI65)




1H NMR (400 MHz, CDCl3) δ 7.94 (d, J=8.0 Hz, 1H), 7.67 (s, 1H), 7.36 (m, 3H), 6.56 (d, J=15.6 Hz, 1H), 6.44 (dd, J=15.6, 8.0 Hz, 1H), 4.42 (q, J=6.8 Hz, 2H), 4.10 (m, 1H), 1.42 (t, J=6.8 Hz, 3H); ESIMS m/z 498.74 ([M−H]−); IR (thin film) 1726, 1114, 820, 623 cm−1.
(E)-Ethyl 2-methyl-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)benzoate (AI66)




The title compound was isolated as a brown semi-solid: 1H NMR (400 MHz, CDCl3) δ 7.90 (d, J=8.8 Hz, 1H), 7.34 (d, J=6.0 Hz, 2H), 7.25 (d, J=7.2 Hz, 2H), 6.59 (d, J=16.0 Hz, 1H), 6.42 (dd, J=16.0 Hz, 8.0 Hz, 1H), 4.38 (q, J=7.2 Hz, 2H), 4.19 (m, 1H), 2.63 (s, 3H), 1.41 (t, J=7.2 Hz, 3H); ESIMS m/z 432.90 ([M−H]−); IR (thin film) 1715 cm−1.
(E)-Methyl 2-methoxy-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)benzoate (AI67)




1H NMR (400 MHz, CDCl3) δ 7.80 (d, J=8.4 Hz, 1H), 7.35 (d, J=6.0 Hz, 2H), 7.03 (d, J=1.2 Hz, 1H), 6.92 (s, 1H), 6.59 (d, J=15.6 Hz, 1H), 6.42 (dd, J=15.6, 8.0 Hz, 1H), 4.13 (m, 1H), 3.93 (s, 3H), 3.88 (s, 3H); ESIMS m/z 437.29 ([M+H]+); IR (thin film) 1724 cm−1.
(E)-Ethyl 2-ethyl-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)benzoate (AI68)




1H NMR (400 MHz, CDCl3) δ 7.85 (d, J=8.0 Hz, 1H), 7.35 (d, J=9.6 Hz, 2H), 7.26 (m, 1H), 7.24 (m, 1H), 6.60 (d, J=15.6 Hz, 1H), 6.42 (dd, J=15.6, 8.0 Hz, 1H), 4.38 (q, J=7.2 Hz, 2H), 4.14 (m, 1H), 3.01 (q, J=7.6 Hz 2H), 1.41 (t, J=7.2 Hz, 3H), 1.26 (t, J=7.6 Hz, 3H); ESIMS m/z 447.05 ([M−H]−); IR (thin film) 1715, 1115, 817 cm−1.
(E)-Ethyl 4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(methylthio)benzoate 




Isolated as a brown liquid: 1H NMR (400 MHz, CDCl3) δ 7.99 (d, J=8.1 Hz, 2H), 7.35-7.32 (m, 2H), 7.21-7.16 (m, 2H), 6.63 (d, J=15.8 Hz, 1H), 6.45 (dd, J=15.9, 7.8 Hz, 1H), 4.41-4.31 (m, 2H), 4.30-4.10 (m, 1H), 2.47 (s, 3H), 1.40 (t, J=7.5 Hz, 3H); ESIMS m/z 466.88 ([M+H]+); IR (thin film) 1705, 1114 cm−1.
(E)-Ethyl 2-bromo-4-(3-(3,5-difluoro-4-methoxyphenyl)-4,4,4-trifluorobut-1-en-1-yl)benzoate




The product was isolated as a pale yellow liquid: 1H NMR (400 MHz, CDCl3) δ 7.78 (d, J=8.0 Hz, 1H), 7.66 (d, J=1.6 Hz, 1H), 7.35-7.33 (m, 1H), 6.96-6.90 (m, 2H), 6.54 (d, J=15.6 Hz, 1H), 6.43 (dd, J=15.6, 8.0 Hz, 1H), 4.39 (q, J=6.8 Hz, 2H), 4.09-4.05 (m, 1H), 4.02 (s, 3H), 1.40 (t, J=7.2 Hz, 3H); EIMS m/z 478.2 ([M]+); IR (thin film) 1727, 1113 cm−1.
Example 11
Preparation of (E)-4-(3-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-1-enyl)-2-methylbenzoic acid (AI32)




To a stirred solution of (E)-ethyl 4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-enyl) -2-methylbenzoate (1.7 g, 4.0 mmol) in 1,4-dioxane (10 mL) was added 11 N HCl (30 mL), and the reaction mixture was heated at 100° C. for 48 h. The reaction mixture was cooled to 25° C. and concentrated under reduced pressure. The residue was diluted with water and extracted with chloroform (CHCl3). The combined organic layer was dried over Na2SO4 and concentrated under reduced pressure, and the crude compound was washed with n-hexane to afford the title compound as a white solid (0.7 g, 50%): mp 142-143° C.; 1H NMR (400 MHz, DMSO-d6) δ 12.62 (br s, 1H), 7.81 (d, J=8.0 Hz, 1H), 7.66 (s, 3H), 7.52-7.44 (m, 2H), 6.89 (dd, J=16.0, 8.0 Hz, 1H), 6.78-6.74 (d, J=16.0 Hz, 1H), 4.84 (m, 1H), 2.50 (s, 3H); ESIMS m/z 387.05 ([M−H]−); IR (thin film) 3448, 1701, 1109, 777 cm−1.
The following compounds were made in accordance with the procedures disclosed in Example 11.
(E)-2-Methyl-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzoic acid (AI26)




The product was isolated as a pale brown gummy liquid (1 g, 46%): 1H NMR (400 MHz, CDCl3) δ 7.97 (d, J=8.0 Hz, 1H), 7.77 (s, 1H), 7.65 (m, 1H), 7.41 (s, 2H), 6.68 (d, J=16.0 Hz, 1H), 6.53 (dd, J=16.0, 8.0 Hz, 1H), 4.16 (m, 1H), 2.50 (s, 3H); ESIMS m/z 422.67 ([M−H]−).
(E)-2-Chloro-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzoic acid (AI27)




The product was isolated as an off-white semi-solid (1 g, 45%): 1H NMR (400 MHz, CDCl3) δ 7.99 (d, J=8.4 Hz, 1H), 7.50 (m, 1H), 7.40 (s, 1H), 7.36 (m, 2H), 6.59 (d, J=15.6 Hz, 1H), 6.48 (dd, J=15.6, 7.6 Hz, 1H), 4.14 (m, 1H); ESIMS m/z 442.72 ([M−H]−); IR (thin film) 3472, 1704, 1113, 808 cm−1.
(E)-2-Bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzoic acid (AI28)




The product was isolated as a brown solid (1 g, 45%): mp 70-71° C.; 1H NMR (400 MHz, CDCl3) δ 7.99 (d, J=8.0 Hz, 1H), 7.72 (s, 1H), 7.40 (m, 3H), 6.58 (d, J=16.0 Hz, 1H), 6.48 (dd, J=16.0, 8.0 Hz, 1H), 4.14 (m, 1H); ESIMS m/z 484.75 ([M−H]−); IR (thin film) 3468, 1700 cm−1.
(E)-2-Cyano-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzoic acid (AI29) 




The product was isolated as an off-white solid (500 mg, 45%): mp 100-101° C.; 1H NMR (400 MHz, CDCl3) δ 7.90 (s, 1H), 7.85 (d, J=7.6 Hz, 1H), 7.72 (d, J=8.0 Hz, 1H), 7.65 (br s, 1H), 7.42 (s, 2H), 6.73 (d, J=16.0 Hz, 1H), 6.58 (dd, J=16.0, 8.0 Hz, 1H), 4.19 (m, 1H); ESIMS m/z 431.93 ([M−H]−).
E)-4-(3-(3,4-Dichlorophenyl)-4,4,4-trifluorobut-1-enyl)-2-methylbenzoic acid (AI30)




The product was isolated as a pale brown liquid (500 mg, 46%): 1H NMR (400 MHz, CDCl3) δ 8.03 (m, 1H), 7.49 (m, 2H), 7.29 (m, 1H), 7.22 (m, 2H), 6.73 (d, J=16.0 Hz, 1H), 6.58 (dd, J=16.0, 7.8 Hz, 1H), 4.16 (m, 1H), 2.64 (s, 3H); ESIMS m/z 386.84 ([M−H]−); IR (thin film) 3428, 1690, 1113, 780 cm−1.
(E)-4-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-2-methylbenzoic acid (AI31)




The product was isolated as a white solid (500 mg, 50%): mp 91-93° C.; 1H NMR (400 MHz, CDCl3) δ 8.02 (d, J=8.0 Hz, 1H), 7.35 (d, J=5.6 Hz, 1H), 7.30 (m, 3H), 6.61 (d, J=16.0 Hz, 1H), 6.48 (dd, J=16.0, 8.0 Hz, 1H), 4.13 (m, 1H), 2.65 (s, 3H); ESIMS m/z 406.87 ([M−H]−).
(E)-4-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-2-(trifluoromethyl)benzoic acid (AI33)




The product was isolated as a white solid (500 mg, 45%): mp 142-143° C.; 1H NMR (400 MHz, CDCl3) δ 7.97 (d, J=8.0 Hz, 1H), 7.77 (s, 1H), 7.65 (m, 1H), 7.41 (s, 2H), 6.68 (d, J=16.0 Hz, 1H), 6.53 (dd, J=16.0, 8.0 Hz, 1H), 4.16 (m, 1H); ESIMS m/z 474.87 ([M−H]−).
(E)-2-Bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzoic acid (AI69)




The title compound was isolated as a brown solid (0.8 g, 28%): 1H NMR (400 MHz, CDCl3) δ 13.42 (br, 1H), 7.98 (d, J=1.5 Hz, 1H), 7.94 (m, 2H), 7.75 (d, J=8.1 Hz, 1H), 7.65 (m, 1H), 7.06 (dd, J=15.9, 9.0 Hz, 1H), 6.80 (d, J=15.9 Hz, 1H), 4.91 (m, 1H); ESIMS m/z 484.75 ([M−H]−); IR (thin film) 3469, 1700 cm−1.
(E)-2-Bromo-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluo robut-1-enyl)benzoic acid (AI70)




The title compound was isolated as a yellow liquid (0.3 g, crude): 1H NMR (300 MHz, CDCl3) δ 7.79 (d, J=8.1 Hz, 1H), 7.67 (s, 1H), 7.34 (m, 3H), 6.56 (d, J=15.9 Hz, 1H), 6.45 (dd, J=15.9, 7.6 Hz, 1H), 4.43 (m, 1H); ESIMS m/z 471.0 ([M−H]−).
(E)-4-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-2-ethylbenzoic acid (AI71)




The title compound was isolated as a brown gummy material (0.2 g, crude): 1H NMR (300 MHz, DMSO-d6) δ 12.5 (br, 1H), 7.85 (d, J=6.3 Hz, 2H), 7.75 (d, J=8.1 Hz, 1H), 7.52 (m, 2H), 6.96 (dd, J=8.7, 8.7 Hz, 1H), 6.78 (d, J=15.6 Hz, 1H), 4.80 (m, 1H), 4.06 (q, J=7.2 Hz, 2H), 1.33 (t, J=7.2 Hz, 3H); ESIMS m/z 419.06 ([M−H]−).
(E)-2-Chloro-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)benzoic acid (AI72) 




The title compound was isolated as a yellow liquid (0.7 g, 95%): 1H NMR (300 MHz, CDCl3) δ 7.85 (d, J=6.0 Hz, 1H), 7.46 (d, J=1.8 Hz, 1H), 7.41 (s, 3H), 6.57 (d, J=16.0 Hz, 1H), 6.45 (dd, J=16.0, 8.0 Hz, 1H), 4.16 (m, 1H); ESIMS m/z 455.0 ([M+H]+); IR (thin film) 1728, 1115, 817 cm−1.
(E)-4-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-2-methylbenzoic acid (AI73)




The title compound was isolated as a light brown gummy material (0.7 g, 38%): mp 91-93° C.; 1H NMR (400 MHz, CDCl3) δ 8.02 (d, J=8.0 Hz, 1H), 7.35 (d, J=5.6 Hz, 1H), 7.30 (m, 3H), 6.10 (d, J=16.0 Hz, 1H), 6.46 (dd, J=16.0, 8.0 Hz, 1H), 4.03 (m, 1H), 2.65 (s, 3H); ESIMS m/z 406.87 ([M−H]−).
(E)-4-(3-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-1-enyl)-2-fluorobenzoic acid (AI74)




The title compound was isolated as a light brown liquid (0.3 g, crude): ESIMS m/z 393.15 ([M−H]−).
(E)-2-Bromo-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-enyl)benzoic acid (AI75)




The title compound was isolated as a light brown liquid (0.35 g, crude): ESIMS m/z 451.91 ([M−H]−).
(E)-4-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(methylthio)benzoic acid




1H NMR (400 MHz, CDCl3) δ 7.88-7.85 (m, 3H), 7.46 (d, J=6.8 Hz, 1H), 7.37 (s, 1H), 6.99 (dd, J=15.6, 8.8 Hz, 1H), 6.85 (d, J=16.0 Hz, 1H), 4.85-4.81 (m, 2H), 2.45 (s, 3H); ESIMS m/z 436.89 ([M−H]−); IR (thinfilm) 3469, 1686, 1259, 714 cm−1.
(E)-2-Bromo-4-(3-(3,5-difluoro-4-methoxyphenyl)-4,4,4-trifluorobut-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown liquid: 1H NMR (300 MHz, DMSO-d6) δ 13.48 (bs, 1H), 8.03 (s, 1H), 7.81 (d, J=7.8 Hz, 1H), 7.69 (d, J=8.1 Hz, 1H), 7.48 (d, J=9.3 Hz, 2H), 7.05 (dd, J=15.6, 9.0 Hz, 1H), 6.83 (d, J=15.9 Hz, 1H), 4.86-4.74 (m, 1H), 4.00 (s, 3H); EIMS m/z 451.18 ([M]+); IR (thin film) 3431, 1132 cm−1.
Prophetically, compounds AI34, AI36-AI41, AI44-AI45 (Table 1) could be made in accordance with the procedures disclosed in Example 10, or Examples 10 and 11.
Example 12
Preparation of (E)-4-(3-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-1-enyl)-2-methyl-N-(2,2,2-trifluoroethyl)benzamide (AC6)




To a stirred solution of (E)-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-enyl)-2-methylbenzoic acid in DMF was added 2,2,2-trifluoroethylamine, HOBt.H2O, EDC.HCl and DIPEA, and the reaction mixture was stirred at 25° C. for 18 h. The reaction mixture was diluted with water and extracted with EtOAc. The combined organic layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure. Purification by flash column chromatography (SiO2, 100-200 mesh; eluting with hexane:EtOAc afforded a white semi-solid (110 mg, 50%): 1H NMR (400 MHz, CDCl3) 7.40 (m, 2H), 7.26 (m, 3H), 6.56 (d, J=16.0 Hz, 1H), 6.48 (dd, J=16.0, 8.0 Hz, 1H), 5.82 (br s, 1H), 4.08 (m, 3H), 2.52 (s, 3H); ESIMS m/z 468.40 ([M−H]−); IR (thin film) 1657, 1113, 804 cm−1.
Compounds AC7-AC38, AC40-AC58, AC110-AC112, AC117, and AC118 (Table 1) were made in accordance with the procedures disclosed in Example 12.
Example 13
Preparation of 4-((E)-3-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-1-enyl)-2-methyl-N-((pyrimidin-5-yl)methyl)benzamide (AC39)




To a stirred solution of (pyrimidin-5-yl)methanamine (0.15 g, 1.43 mmol) in CH2Cl2 (10 mL) was added drop wise trimethylaluminum (2 M solution in toluene; 0.71 mL, 1.43 mmol), and the reaction mixture was stirred at 25° C. for 30 min A solution of ethyl 4-((E)-3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-enyl)-2-methylbenzoate (0.3 g, 0.71 mmol) in CH2Cl2 was added drop wise to the reaction mixture at 25° C. The reaction mixture was stirred at reflux for 18 h, cooled to 25° C., quenched with 0.5 N HCl solution (50 mL) and extracted with EtOAc (2×50 mL). The combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The crude compound was purified by flash chromatography (SiO2, 100-200 mesh; eluting with 40% EtOAc in n-hexane) to afford the title compound (0.18 g, 55%): mp 141-144° C.; 1H (400 MHz, CDCl3) δ 9.19 (s, 1H), 8.79 (s, 2H), 7.37 (m, 2H), 7.23 (m, 2H), 7.21 (m, 1H), 6.57 (d, J=16.0 Hz, 1H), 6.40 (dd, J=16.0, 7.6 Hz 1H), 6.21 (m, 1H), 4.65 (s, 2H), 4.11 (m, 1H), 2.46 (s, 3H); ESIMS m/z 477.83 ([M−H]−).
Example 14
Preparation of (E)-2-Chloro-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide (AC64)




To a stirred solution of glycine amide (0.15 g, 0.58 mmol) in CH2Cl2 (5 mL) was added trimethylaluminum (2 M solution in toluene; 1.45 mL, 2.91 mmol) dropwise, and the reaction mixture was stirred at 28° C. for 30 min A solution of (E)-ethyl 2-chloro-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzoate (0.3 g, 0.58 mmol) in CH2Cl2 (5 mL) was added drop wise to the reaction mixture at 28° C. The reaction mixture was stirred at reflux for 18 h, cooled to 25° C., quenched with 1N HCl solution (50 mL) and extracted with CH2Cl2 (2×50 mL). The combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The crude compound was purified by flash chromatography (SiO2, 100-200 mesh; eluting with 40% EtOAc in n-hexane) to afford the title compound as yellow solid (0.15 g, 50%): mp 83-85° C.; 1H NMR (400 MHz, CDCl3) δ 7.72 (d, J=8.0 Hz, 1H), 7.44 (s, 1H), 7.40 (s, 2H), 7.36 (d, J=6.8 Hz, 1H), 7.05 (t, J=5.2 Hz, 1H), 6.70 (t, J=5.2 Hz, 1H), 6.57 (d, J=15.6 Hz, 1H), 6.44 (dd, J=15.6, 8.0 Hz, 1H), 4.23 (d, J=5.6 Hz, 2H), 4.15 (m, 1H), 4.01 (m, 2H); ESIMS m/z 580.72 ([M−H]−).
Compounds AC59-AC75 (Table 1) were made in accordance with the procedures disclosed in Example 14.
Example 15
Preparation of (E)-2-Bromo-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)benzamide (AC79)




To a stirred solution of (E)-2-bromo-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)benzoic acid (300 mg, 0.638 mmol) in CH2Cl2 (5.0 mL) was added 2-amino-N-(2,2,2-trifluoroethyl)acetamide (172. mg, 0.638 mmol) followed by PyBOP (364.5 mg, 0.701 mmol) and DIPEA (0.32 mL, 1.914 mmol), and the resultant reaction mixture was stirred at ambient temperature for 18 h. The reaction mixture was diluted with water and extracted with CH2Cl2. The combined CH2Cl2 layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure. Purification by flash column chromatography (SiO2, 100-200 mesh; eluting with 40% EtOAc/petroleum ether) afforded the title compound as an off-white solid (121 mg, 31%): 1H NMR (400 MHz, CDCl3) δ 8.69 (t, J=6.0 Hz, 1H), 8.58 (t, J=6.0 Hz, 1H), 7.92 (s, 1H), 7.87 (d, J=6.4 Hz, 2H), 7.62 (d, J=8.4 Hz, 1H), 7.45 (d, J=8.4 Hz, 1H), 7.0 (m, 1H), 6.76 (d, J=15.6 Hz, 1H), 4.83 (t, J=8.0 Hz, 1H), 3.98 (m, 4H); ESIMS m/z 610.97 ([M+H]+); IR (thin film) 3303, 1658, 1166, 817 cm−1.
Compounds AC76-AC80, AC96-AC102, and AC113 (Table 1) were made in accordance with the procedures disclosed in Example 15.
Example 16
Preparation of (E)-4-(3-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-N -(1,1-dioxidothietan-3-yl)-2-fluorobenzamide (AC83)




To a stirred solution of (E)-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-enyl)-2-fluoro-N-(thietan-3-yl)benzamide (100 mg, 0.2159 mmol) in acetone/water (1:1, 5.0 mL) was added oxone (266 mg, 0.4319 mmol) and the resultant reaction mixture was stirred at ambient temperature for 4 h. The reaction mixture was diluted with water and extracted with EtOAc. The combined EtOAc layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure. Purification by flash column chromatography (SiO2, 100-200 mesh; eluting with 30% EtOAc/pet ether) afforded the title compound as an off white solid (70.0 mg, 66%): 1H NMR (400 MHz, CDCl3) δ 8.07 (t, J=8.4 Hz, 1H), 7.39 (t, J=1.6 Hz, 1H), 7.31 (d, J=1.2 Hz, 1H), 7.26 (m, 2H), 7.23 (m, 2H), 7.19 (d, J=1.6 Hz, 1H), 6.60 (d, J=16.8 Hz, 1H), 6.49 (dd, J=16.8, 7.6 Hz, 1H), 4.90 (m, 1H), 4.64 (m, 2H), 4.14 (m, 2H),; ESIMS m/z 493.83 ([M−H]−); IR (thin film) 1527, 1113, 801, 1167, 1321 cm−1.
Compounds AC81-AC87 (Table 1) were made in accordance with the procedures disclosed in Example 16.
Example 17
Preparation of (E)-N-((5-Cyclopropyl-1,3,4-oxadiazol-2-yl)methyl)-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-methylbenzamide (AC89)




A solution of (E)-N-(2-(2-(cyclopropanecarbonyl)hydrazinyl)-2-oxoethyl)-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-enyl)-2-methylbenzamide (200 mg, 0.379 mmol) in phosphoryl chloride (POCl3, 2.0 mL) was stirred at ambient temperature for 10 min, then the resultant reaction mixture was heated to 50° C. for 1 h. The reaction mixture was quenched with ice water at 0° C. and extracted with EtOAc. The combined EtOAc layer was washed with saturated sodium bicarbonate (NaHCO3) solution and brine solution, dried over anhydrous Na2SO4, and concentrated under reduced pressure. Purification by flash column chromatography (SiO2, 100-200 mesh; eluting with 50% EtOAc/pet ether) afforded the title compound as a light brown gummy material (70.0 mg, 36%): 1H NMR (400 MHz, CDCl3) δ 7.43 (m, 2H), 7.27 (m, 2H), 7.23 (m, 2H), 6.58 (d, J=16.0 Hz, 1H), 6.41 (dd, J=16.0, 7.6 Hz, 1H), 4.79 (d, J=5.6 Hz, 2H), 4.14 (m, 1H), 2.48 (s, 3H), 2.18 (m, 1H), 1.16 (m, 4H); ESIMS m/z 509.89 ([M+H]+); IR (thin film) 1666, 1166, 1112, 800 cm−1.
Example 18
Preparation of (E)-2-Bromo-N-(2-thioxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzothioamide (AC90)




To a stirred solution of (E)-2-bromo-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl) -4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide (400 mg, 0.638 mmol) in 5 mL of THF at ambient temperature was added 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (Lawesson's reagent) (336 mg, 0.830 mmol) in one portion. The resulting reaction mixture was stirred for 18 h. TLC showed the reaction was not complete, therefore additional Lawesson's reagent (168 mg, 0.415 mmol) was added and reaction stirred for 48 h. After the reaction was deemed complete by TLC, the reaction mixture was concentrated under reduced pressure. Purification by flash chromatography (SiO2, 230-400 mesh; eluting with 20% EtOAc in hexanes) afforded the title compound as a yellow glassy oil (188 mg, 44.7%): 1H NMR (400 MHz, CDCl3) δ 8.34 (m, 1H), 8.27 (m, 1H), 7.60 (d, J=1.6 Hz, 1H), 7.49 (d, J=8.0 Hz, 2H), 7.40 (s, 2H), 7.36 (dd, J=8.2, 1.7 Hz, 1H), 6.53 (d, J=16.0 Hz, 1H), 6.38 (dd, J=15.9, 7.9 Hz, 1H), 4.89 (d, J=8.4, 5.5 Hz, 2H), 4.48 (qd, J=9.0, 6.0 Hz, 2H), 4.11 (m, 1H); ESIMS m/z 656.9 ([M−H]−).
Example 19
Preparation of (E)-2-(2-Bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)phenylthioamido)-N-(2,2,2-trifluoroethyl)acetamide (AC91)




To a stirred solution of (E)-2-bromo-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl) -4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide (400 mg, 0.638 mmol) in 5 mL of THF at ambient temperature was added Lawesson's reagent (64.5 mg, 0.160 mmol) in one portion. The resulting reaction mixture was stirred for 18 h, after which time, the reaction mixture was concentrated under reduced pressure. Purification by flash chromatography (SiO2, 230-400 mesh; eluting with 20% EtOAc in hexanes) afforded the title compounds as a yellow oil (18.5 mg, 4.51%): 1H NMR (400 MHz, CDCl3) δ 8.18 (t, J=5.0 Hz, 1H), 7.58 (d, J=1.6 Hz, 1H), 7.47 (d, J=8.0 Hz, 1H), 7.40 (s, 2H), 7.34 (dd, J=8.1, 1.6 Hz, 1H), 6.52 (m, 2H), 6.37 (dd, J=15.9, 7.9 Hz, 1H), 4.54 (d, J=4.9 Hz, 2H), 4.12 (m, 1H), 3.99 (qd, J=8.9, 6.5 Hz, 2H); ESIMS m/z 640.9 ([M−H]−).
The following compound was made in accordance with the procedures disclosed in Example 19.
(E)-2-Bromo-N-(2-thioxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide (AC92)




The product was isolated as a colorless oil (17.9 mg, 4.36%): 1H NMR (400 MHz, CDCl3) δ 9.16 (d, J=6.1 Hz, 1H), 7.65 (d, J=1.6 Hz, 1H), 7.57 (d, J=8.0 Hz, 1H), 7.41 (m, 3H), 7.21 (t, J=5.6 Hz, 1H), 6.55 (d, J=15.9 Hz, 1H), 6.41 (dd, J=15.9, 7.8 Hz, 1H), 4.59 (d, J=5.6 Hz, 2H), 4.45 (qd, J=9.0, 6.0 Hz, 2H), 4.12 (q, J=7.2 Hz, 1H); ESIMS m/z 640.9 ([M−H]−).
Example 106
Preparation of Ethyl (Z)-2-Bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzoate (AI76)




The title compound was made in accordance with the procedure disclosed in Example 88 and was isolated as a yellow viscous oil (416 mg, 23%): 1H NMR (400 MHz, CDCl3) δ 7.80 (d, J=8.0 Hz, 1H), 7.40 (d, J=1.7 Hz, 1H), 7.35 (s, 2H), 7.12 (dd, J=8.0, 1.7 Hz, 1H), 6.86 (d, J=11.4 Hz, 1H), 6.23-5.91 (m, 1H), 4.42 (q, J=7.1 Hz, 2H), 4.33-4.10 (m, 1H), 1.42 (t, J=7.2 Hz, 3H); 19F NMR (376 MHz, CDCl3) δ −69.34 (d, J=8.3 Hz); EIMS m/z 514.10 ([M]−); IR (thin film) 2983, 1727, 1247, 1204, 1116 cm−1.
Example 107
Preparation of (Z)-2-Bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzoic acid (AI77) 




To a stirred solution of (Z)-ethyl 2-bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzoate (360 mg, 0.70 mmol) in CH3CN (1.0 mL) was added iodotrimethylsilane (0.28 mL, 2.8 mmol). The reaction mixture was heated to reflux for 20 h, allowed to cool to ambient temperature and partitioned between CH2Cl2 and aqueous 10% sodium thiosulfate (Na2S2O3). The organic phase was washed once with aqueous 10% Na2S2O3 and dried over magnesium sulfate (MgSO4) and concentrated in vacuo. Passing the material through a silica plug with 10% EtOAc in hexanes, followed by 20% MeOH in CH2Cl2) as the eluting solvents afforded the title compound as a yellow foam (143 mg, 42%): mp 54-64° C.; 1H NMR (400 MHz, CDCl3) δ 11.36 (s, 1H), 7.99 (d, J=8.0 Hz, 1H), 7.43 (s, 1H), 7.30 (s, 2H), 7.14 (d, J=7.9 Hz, 1H), 6.85 (d, J=11.4 Hz, 1H), 6.15 (t, J=10.9 Hz, 1H), 4.36-4.09 (m, 1H); 19F NMR (376 MHz, CDCl3) δ −69.30.
Example 108
Preparation of (Z)-2-Bromo-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide (AC95)




To a stirred solution of (Z)-2-bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzoic acid (200 mg, 0.41 mmol) in anhydrous THF (5.0 mL) was added carbonyldiimidazole (82 mg, 0.51 mmol). The mixture was heated in a 50° C. oil bath for 1.5 h, treated with 2-amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride (109 mg, 0.057 mmol) and the resulting mixture heated to reflux for 8 h. After cooling to ambient temperature, the mixture was taken up in Et2O and washed twice with aqueous 5% sodium bisulfate (NaHSO4) (2×) and once with saturated NaCl (1×). After dying over MgSO4, concentration in vacuo and purification by medium pressure chromatography on silica with EtOAc/Hexanes as the eluents, the title compound was obtained as a white foam (160 mg, 41%) mp 48-61° C.: 1H NMR (400 MHz, CDCl3) δ 7.58 (d, J=7.9 Hz, 1H), 7.44-7.29 (m, 3H), 7.14 (dd, J=7.9, 1.6 Hz, 1H), 6.86 (d, J=11.4 Hz, 1H), 6.76 (t, J=5.9 Hz, 1H), 6.59 (br s, 1H), 6.21-6.04 (m, 1H), 4.23 (d, J=5.5 Hz, 1H), 3.98 (qd, J=9.0, 6.5 Hz, 2H); 19F NMR (376 MHz, CDCl3) δ −69.31, −72.3; EIMS m/z 626.9 ([M+H]+).
Example 109a
Preparation of (E)-2-Bromo-N-(piperidin-4-yl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide (AC114)




(E)-tert-Butyl 4-(2-bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzamido)piperidine-1-carboxylate (0.75 g, 1.11 mmol) was added to dioxane HCl (10 mL) at 0° C. and was stirred for 18 h. The reaction mixture was concentrated under reduced pressure and triturated with diethylether to afford the compound as a light brown solid (0.6 g, 88%).
Example 109b
Preparation of (E)-N-(1-Acetylpiperidin-4-yl)-2-bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide (AC103)




To a stirred solution of (E)-2-bromo-N-(piperidin-4-yl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzamide (0.1 g, 0.16 mmol) in CH2Cl2 (10.0 mL) was added TEA (0.046 mL, 0.35 mmol) and stirred for 10 min. Then acetyl chloride (0.014, 0.18 mmol) was added and stirred for 16 h at ambient temperature. The reaction mixture was diluted with CH2Cl2 and washed with saturated NaHCO3 solution and brine solution. The combined CH2Cl2 layer was dried over Na2SO4 and concentrated under reduced pressure to afford crude compound. The crude compound was washed with 5% Et2O/n-pentane to afford the title compound as a white solid (0.054 g, 50%).
Example 110
Preparation of (E)-2-Bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)-N-(1-(3,3,3-trifluoropropanoyl)piperidin-4-yl)benzamide (AC104) 




To a stirred solution of 3,3,3-trifluoropropanoic acid (0.02 g, 0.16 mmol) in CH2Cl2 (10.0 mL), (E)-2-bromo-N-(piperidin-4-yl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzamide (0.1 g, 0.16 mmol), PYBOP (0.09 g, 0.17 mmol), and DIPEA (0.06 g, 0.48 mmol) were added at ambient temperature. The reaction mixture was stirred at ambient temperature for 5 h. The reaction mixture was diluted with CH2Cl2. The combined CH2Cl2 layer was washed with 3N HCl and saturated NaHCO3 solution, the separated CH2Cl2 layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford crude compound. The crude compound was purified by column chromatography (SiO2, 100-200 mesh; eluting with 2% MeOH in CH2Cl2) to afford the title compound as an off white gummy material (0.035 g, 29. %).
Example 111
Preparation of (E)-2-Bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)-N-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)benzamide (AC105)




To a stirred solution of (E)-2-bromo-N-(piperidin-4-yl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzamide (0.1 g, 0.16 mmol) in THF (5.0 mL) was added TEA (0.06 mL, 0.64 mmol) and stirred for 10 min. Then 2,2,2-trifluoroethyl trifluoromethanesulfonate (0.03, 0.16 mmol) was added and stirred for 16 h at ambient temperature. The reaction mixture was diluted with EtOAc and washed with saturated NaHCO3 solution and brine solution. The combined EtOAc layer was dried over Na2SO4 and concentrated under reduced pressure to afford the title compound as a brown solid (0.05 g, 44%).
Example 112
Preparation of (E)-2-Bromo-N-(1-methylpiperidin-4-yl)-4-(4,4,4-trifluoro -3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide (AC106)




A solution of (E)-2-bromo-N-(piperidin-4-yl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzamide (0.1 g, 0.16 mmol), formaldehyde (30% in water) (0.1 mL, 0.16 mmol) and AcOH (0.01 mL) in MeOH (5.0 mL) was stirred at ambient temperature for 30 min. After that NaBH3CN (0.01 g, 0.16 mmol) was added at 0° C. and the reaction was stirred for 8 h at ambient temperature. The solvent was removed under reduced pressure to obtain residue which was diluted with EtOAc and washed with saturated aqueous NaHCO3 solution and brine solution. The combined EtOAc layer was dried over Na2SO4 and concentrated under reduced pressure to obtain a residue, which was triturated with Et2O/pentane to afford the title compound as a pale yellow gummy material (0.06 g, 59%).
Example 113
Preparation of ((E)-2-Bromo-N-(1-(cyanomethyl)piperidin-4-yl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide (AC107)




To a stirred solution of (E)-2-bromo-N-(piperidin-4-yl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzamide (0.25 g, 0.43 mmol) in THF (10.0 mL) was added TEA (0.16 mL, 1.29 mmol) and the reaction was stirred for 10 min. Then 2-bromoacetonitrile (0.07, 0.65 mmol) was added and the reaction was stirred for 8 h at ambient temperature. The reaction mixture was diluted with EtOAc and washed with saturated brine solution. The combined EtOAc layer was dried over Na2SO4 and concentrated under reduced pressure to afford the title compound as an off-white solid (0.125 g, 46.8%).
Example 114
Preparation of (E)-2-Bromo-N-(1-(oxetan-3-yl)piperidin-4-yl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide (AC108) 




A solution of (E)-2-bromo-N-(piperidin-4-yl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzamide (0.2 g, 0.35 mmol), oxetan-3-one (0.027 g, 0.38 mmol) and AcOH (0.01 mL) in MeOH (5.0 mL) was stirred at ambient temperature for 30 min. After that NaBH3CN (0.022 g, 0.35 mmol) was added at 0° C. slowly lot wise over the period of 10 min and the reaction was stirred for 8 h at ambient temperature. The solvent was removed under reduced pressure to obtain a residue which was diluted with EtOAc and washed with saturated NaHCO3 solution and brine solution. The combined EtOAc layer was dried over Na2SO4 and concentrated under reduced pressure to obtain a residue, which was triturated with Et2O/pentane to afford the title compound as an off-white solid (0.05 g, 23%).
Example 115
Preparation of (E)-2-Bromo-N-(1-(2-hydroxyethyl)piperidin-4-yl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide (AC109)




To a stirred solution of (E)-2-bromo-N-(piperidin-4-yl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzamide (0.25 g, 0.43 mmol) in THF (10.0 mL) was added TEA (0.16 mL, 1.29 mmol) and the reaction was stirred for 10 min. Then 2-chloroethanol (0.05, 0.65 mmol) was added and the reaction was stirred for 8 h at ambient temperature. The reaction mixture was diluted with EtOAc and washed with saturated brine solution. The combined EtOAc layer was dried over Na2SO4 and concentrated under reduced pressure to afford the title compound as an off-white solid (0.09 g, 34%).
Example 116
Preparation of (E)-2-(2-Bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamido)acetic acid (AI78) 




To a stirred solution of (E)-tert-butyl 2-(2-bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzamido)acetate (440 mg, 0.734 mmol) in CH2Cl2 (36.0 ml), was added TFA (4.0 mL) and the reaction mixture was stirred at ambient temperature for 1 h. The reaction mixture was concentrated under reduced pressure to obtain residue which was washed with n-pentane to afford the title compound as an off-white solid (310 mg, 78%): 1H NMR (400 MHz, CDCl3) δ 13.0 (s, 1H), 8.75 (t, J=5.7 Hz, 1H), 7.93 (m, 2H), 7.62 (d, J=7.5 Hz, 1H), 7.40 (d, J=8.1 Hz, 1H), 6.96 (dd, J=15.3, 9.3 Hz, 1H), 6.78 (d, J=15.3 Hz, 1H), 4.83 (m, 1H), 3.90 (d, J=5.7 Hz, 2H); ESIMS m/z 543.61 ([M+H]+); IR (thin film) 3429, 1635, 1114, 772 cm−1.
Example 117
Preparation of (E)-N-((6-Chloropyridin-3-yl)methyl)-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-methylbenzothioamide (AC115)




To the stirred solution of (E)-N-((6-chloropyridin-3-yl)methyl)-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-enyl)-2-methylbenzamide (0.06 g, 0.117 mmol) in toluene (3 mL) was added Lawesson's reagent (0.14 g, 0.351 mmol) and the reaction was irradiated at 100° C. for 1 h, then cooled to ambient temperature and concentrated under reduced pressure to provide crude compound. The crude product was purified by preparative HPLC to afford the product as yellow color solid (0.03 g, 49%).
Example 118
Preparation of (E)-4-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut -1-en-1-yl)-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-2-(trifluoromethoxy)benzamide (AC116)




Step 1. 2-(Trifluoromethoxy)-4-vinylbenzoic acid (AI79) To a stirred solution of 4-bromo-2-(trifluoromethoxy)benzoic acid (1 g, 3.67 mmol) in DMSO (20 mL) was added potassium vinyltrifluoroborate (1.47 g, 11.02 mmol) and K2CO3 (1.52 g, 11.02 mmol). The reaction mixture was degassed with argon for 30 min Bistriphenylphosphine(diphenylphosphinoferrocene)palladium dichloride (0.13 g, 0.18 mmol) was added and the reaction mixture was heated to 80° C. for 1 h. The reaction mixture was diluted with water (100 mL), extracted with EtOAc (2×50 mL), washed with brine, and dried over Na2SO4. Concentration under reduced pressure furnished the crude compound which was purified by flash column chromatography to afford the product as pale yellow gummy material (0.4 g, 47%): 1H NMR (400 MHz, CDCl3) δ 8.05 (d, J=8.1 Hz, 1H), 7.44 (d, J=1.8 Hz, 1H), 7.35 (s, 1H), 6.78 (dd, J=17.4.1, 11.1 Hz, 1H), 5.92 (d, J=17.4 Hz, 1H), 5.51 (d, J=10.8 Hz, 1H); ESIMS m/z 232.97 ([M+H]+).
Step 2. (E)-4-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-2-(trifluoromethoxy)benzoic acid (AI80) To a stirred solution of 2-(trifluoromethoxy)-4-vinylbenzoic acid (0.356 g, 1.53 mmol) in 1N methylpyrrolidine (5.0 mL) was added 1-(1-bromo-2,2,2-trifluoroethyl)-3,5-dichloro 4-fluorobenzene (1.0 g, 3.07 mmol), CuCl (0.03 g, 0.307 mmol) and 2,2 bipyridyl (0.095 g, 0.614 mmol). The reaction mixture was stirred at 150° C. for 1 h. After the reaction was complete by TLC, the reaction mixture was diluted with water (100 mL) and extracted with EtOAc (2×50 mL). The combined organic layers were washed with brine, dried over Na2SO4 and concentrated under reduced pressure to obtain the crude compound which was purified by flash column chromatography to afford the product as pale yellow gummy material (0.3 g, 21%): 1H NMR (400 MHz, CDCl3) δ 8.08 (d, J=8.0 Hz, 1H), 7.45 (d, J=1.6 Hz, 1H), 7.35 (s, 3H), 6.63 (d, J=16.0 Hz, 1H), 6.50 (dd, J=16.0, 8.0 Hz, 1H), 4.15 (m, 1H); ESIMS m/z 474.81 ([M−H]−).
Step 3. (E)-4-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-N-(2-oxo-2-(2,2,2-trifluoroethylamino)ethyl)-2-(trifluoromethoxy)benzamide (AC116) A mixture of (E)-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-2-(trifluoromethoxy)benzoic acid (0.25 g, 0.52 mmol), 2-amino-N-(2,2,2-trifluoroethyl)acetamide (0.158 g, 0.62 mmol), PyBOP (0.40 g, 0.78 mmol) and DIPEA (0.134 g, 1.04 mmol) in CH2Cl2 (10.0 mL) were stirred at ambient temperature for 16 h. The reaction mixture was diluted with water and extracted with CH2Cl2. The combined CH2Cl2 layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure. Purification by flash column chromatography (SiO2, 100-200 mesh; eluting with 20% EtOAc/pet ether) afforded the title compound as a pale yellow gummy material (0.15 g, 47%).
The following molecules were made in accordance with the procedures disclosed in Example 118, Step 2:
(E)-4-(3-(3,5-Dibromophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-methylbenzoic acid




The title molecule was isolated as a brown solid: 1H NMR (400 MHz, DMSO-d6) δ 12.90 (bs, 1H), 7.85 (s, 1H), 7.78-7.75 (m, 3H), 7.47-7.41 (m, 2H), 6.89 (dd, J=15.6, 9.2 Hz, 1H), 6.72 (d, J=15.6 Hz, 1H), 4.80-4.75 (m, 1H), 2.33 (s, 3H); ESIMS m/z 474.90 ([M−H]−); IR (thin film) 3437, 1689, 1165, 579 cm−1.
(E)-4-(3-(3,5-Dibromophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated as a brown solid: 1H NMR (300 MHz, DMSO-d6) δ 13.5 (bs, 1H), 8.03 (s, 1H), 7.95-7.85 (m, 4H), 7.81 (d, J=7.8 Hz, 1H), 7.14 (dd, J=15.6, 9.6 Hz, 1H), 6.90 (d, J=15.9 Hz, 1H), 4.86-4.79 (m, 1H); ESIMS m/z 528.82 ([M−H]+); IR (thin film) 3437, 1707, 1153, 555 cm−1.
(E)-2-Bromo-4-(3-(3,5-dibromophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown liquid: 1H NMR (400 MHz, DMSO-d6) δ 13.90 (bs, 1H), 7.98 (s, 1H), 7.88 (s, 1H), 7.84 (s, 2H), 7.74 (d, J=7.6 Hz, 1H), 7.64 (d, J=8.8 Hz, 1H), 7.04 (dd, J=15.6, 8.8 Hz, 1H), 6.78 (d, J=15.6 Hz, 1H), 4.80-4.78 (m, 1H); ESIMS m/z 538.74 ([M−H]−); IR (thin film) 3424, 1695, 1168, 578 cm−1.
(E)-2-Bromo-4-(4,4,4-trifluoro-3-(3-fluoro-5-(trifluoromethyl)phenyl)but-1-en-1-yl)benzoic acid 




The title molecule was isolated as a brown liquid: 1H NMR (400 MHz, DMSO-d6) δ 13.3 (bs, 1H), 7.93 (s, 1H), 7.82-7.77 (m, 2H), 7.72-7.66 (m, 2H), 7.59 (d, J=8.0 Hz, 1H), 7.03 (dd, J=15.6, 9.2 Hz, 1H), 6.76 (d, J=15.6 Hz, 1H), 4.94-4.90 (m, 1H); ESIMS m/z 469.02 ([M−H]−); IR (thin film) 3444, 1704, 1172, 513 cm−1.
(E)-4-(3-(3,5-Bis(trifluoromethyl)phenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-bromobenzoic acid




The title molecule was isolated as a brown solid: 1H NMR (400 MHz, CDCl3) δ 7.98 (d, J=7.6 Hz, 1H), 7.92 (s, 1H), 7.83 (s, 2H), 7.73 (d, J=1.6 Hz, 1H), 7.42-7.40 (m, 1H), 6.62 (d, J=16.4 Hz, 1H), 6.55 (dd, J=16.0, 8.0 Hz, 1H), 4.40-4.30 (m, 1H); ESIMS m/z 518.94 ([M−H]−); IR (thin film) 3447, 1705, 1171, 526 cm−1.
(E)-2-Bromo-4-(4,4,4-trifluoro-3-(3-(trifluoromethyl)phenyl)but-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown liquid: 1H NMR (300 MHz, DMSO-d6) δ 13.50 (bs, 1H), 7.97-7.87 (m, 3H), 7.78-7.61 (m, 4H), 7.08 (dd, J=15.9, 9.3 Hz, 1H), 6.81 (d, J=15.9 Hz, 1H), 4.97-4.84 (m, 1H); ESIMS m/z 518.94 ([M−H]−); IR (thin film) 3447, 1705, 1171, 526 cm−1.
(E)-2-Bromo-4-(3-(3-chloro-5-(trifluoromethyl)phenyl)-4,4,4-trifluorobut-1-en-1-yl)benzoic acid




The title molecule was isolated as a pale yellow gum: 1H NMR (300 MHz, DMSO-d6) δ 13.9 (s, 1H), 8.03 (s, 1H), 7.96-7.91 (m, 3H), 7.72 (d, J=8.1 Hz, 1H), 7.63-7.60 (m, 1H), 7.11 (dd, J=15.9, 9.6 Hz, 1H), 6.79 (d, J=15.9 Hz, 1H), 4.98-4.91 (m, 1H); ESIMS m/z 484.94 ([M−H]−); IR (thin film) 3444, 1705, 1171, 764 cm−1.
(E)-2-Bromo-4-(4,4,4-trifluoro-3-(4-fluoro-3-(trifluoromethyl)phenyl)but-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown liquid: 1H NMR (300 MHz, CDCl3) δ 8.00 (d, J=8.1 Hz, 1H), 7.71 (s, 1H), 7.61-7.59 (m, 2H), 7.41 (d, J=8.1 Hz, 1H), 7.30-7.24 (m, 1H), 6.59 (dd, J=16.2, 6.0 Hz, 1H), 6.48 (d, J=16.5 Hz, 1H), 4.26-4.21 (m, 1H); ESIMS m/z 469.0 ([M−H]−); IR (thin film) 3444, 1699, 1327 cm−1.
(E)-2-Bromo-4-(4,4,4-trifluoro-3-(3,4,5-trifluorophenyl)but-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) δ 13.60 (bs, 1H), 7.97 (s, 2H), 7.72 (d, J=7.2 Hz, 1H), 7.41-7.31 (m, 2H), 7.04 (dd, J=15.6, 9.0 Hz, 1H), 6.71 (d, J=15.9 Hz, 1H), 4.15-4.11 (m, 1H); ESIMS m/z 438.8 ([M+H]+).
(E)-4-(4,4,4-Trifluoro-3-(2,3,4-trifluorophenyl)but-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) δ 8.00 (s, 1H), 7.93 (d, J=8.4 Hz, 1H), 7.81 (d, J=8.1 Hz, 1H), 7.63-7.60 (m, 1H), 7.47-7.44 (m, 1H), 7.02-7.01 (m, 1H), 5.10-4.90 (m, 1H).
(E)-2-Bromo-4-(4,4,4-trifluoro-3-(2,3,4-trifluorophenyl)but-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown gum and the crude acid was taken on directly to the next step: 1H NMR (300 MHz, DMSO-d6) δ 13.65 (bs, 1H), 7.95 (s, 1H), 7.75 (d, J=7.8 Hz, 1H), 7.62-7.59 (m, 2H), 7.50 (dd, J=15.6, 9.0 Hz, 1H), 6.95 (d, J=15.9 Hz, 1H), 4.86-4.74 (m, 1H); ESIMS m/z 436.92 ([M−H]−); IR (thin film) 3445, 1641, 1116 cm−1.
(E)-4-(4,4,4-Trifluoro-3-(2,4,5-trichlorophenyl)but-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) δ 13.6 (s, 1H), 8.04 (s, 1H), 7.96 (d, J=8.4 Hz, 3H), 7.83 (d, J=8.1 Hz, 1H), 7.17-7.03 (m, 2H), 5.16-5.05 (m, 1H); ESIMS m/z 476.9 ([M−H]−); IR (thin film) 3436, 1651, 1116, 661 cm−1.
(E)-2-Bromo-4-(4,4,4-trifluoro-3-(2,4,5-trichlorophenyl)but-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) δ (300 MHz, DMSO-d6) δ 13.4 (s, 1H), 7.99 (d, J=10.2 Hz, 3H), 7.76 (d, J=8.1 Hz, 1H), 7.65 (d, J=7.8 Hz, 1H), 7.09-6.91 (m, 2H), 5.11-5.05 (m, 1H); ESIMS m/z 486.8 ([M−H]−); IR (thin film) 3436, 1651, 1115, 737 cm−1.
(E)-4-(3-(4-Chloro-3-nitrophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated as a brown gum and the crude acid was taken on directly to the next step: 1H NMR (300 MHz, DMSO-d6) 13.80 (bs, 1H), 8.33 (s, 1H), 7.94-7.81 (m, 5H), 7.75-7.72 (m, 1H), 7.06 (dd, J=15.9, 8.7 Hz, 1H), 6.90 (d, J=15.9 Hz, 1H), 5.02-4.81 (m, 1H).
(E)-2-Bromo-4-(3-(4-chloro-3-nitrophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzoic acid 




The title molecule was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) 13.50 (bs, 1H), 8.31 (s, 1H), 8.00-7.77 (m, 3H), 7.75-7.72 (m, 1H), 7.63-7.55 (m, 1H), 7.03 (dd, J=15.9, 9.0 Hz, 1H), 6.81 (d, J=15.9 Hz, 1H), 5.04-4.91 (m, 1H).; ESIMS m/z 462.16 ([M−H]−); IR (thin film) 3428, 1697, 1113, 749 cm−1.
(E)-4-(4,4,4-Trifluoro-3-(4-fluoro-3,5-dimethylphenyl)but-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) δ 7.96 (s, 1H), 7.92 (d, J=8.4 Hz, 1H), 7.80-7.75 (m, 1H), 7.27 (d, J=6.9 Hz, 2H), 6.96 (dd, J=15.6, 8.7 Hz, 1H), 6.87 (d, J=15.6 Hz, 1H), 4.68-4.56 (m, 1H), 2.23 (s, 6H); ESIMS m/z 419.03 ([M−H]−); IR (thin film) 3445, 2928, 1713, 1146 cm−1.
(E)-2-Bromo-4-(4,4,4-trifluoro-3-(4-fluoro-3,5-dimethylphenyl)but-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) δ 7.91 (s, 1H), 7.74 (d, J=7.8 Hz, 1H), 7.61-7.58 (m, 1H), 7.26 (d, J=6.6 Hz, 2H), 6.93 (dd, J=15.9, 8.7 Hz, 1H), 6.87 (d, J=15.9 Hz, 1H), 4.59-4.53 (m, 1H), 2.23 (s, 6H); ESIMS m/z 428.97 ([M−H]−); IR (thin film) 3473, 1701, 1111, 581 cm−1.
(E)-4-(4,4,4-Trifluoro-3-(4-fluoro-3-methylphenyl)but-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated as a brown liquid: 1H NMR (300 MHz, DMSO-d6) δ 13.58 (bs, 1H), 7.98 (s, 1H), 7.92-7.90 (m, 1H), 7.80 (d, J=8.1 Hz, 1H), 7.48-7.45 (m, 1H), 7.42-7.37 (m, 1H), 7.22-7.16 (m, 1H), 7.04 (dd, J=15.9, 8.7 Hz, 1H), 6.88 (d, J=15.9 Hz, 1H), 4.70-4.60 (m, 1H), 4.04-3.99 (m, 1H), 2.26 (s, 3H); ESIMS m/z 405.05 ([M−H]−); IR (thin film) 3437, 1710, 1145 cm−1.
(E)-2-Bromo-4-(4,4,4-trifluoro-3-(4-fluoro-3-methylphenyl)but-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown liquid: 1H NMR (300 MHz, DMSO-d6) δ 13.39 (bs, 1H), 7.91 (s, 1H), 7.72 (d, J=8.1 Hz, 1H), 7.61-7.58 (m 1H), 7.47-7.44 (m, 1H), 7.38-7.36 (m, 1H), 7.18 (t, J=9.6 Hz, 1H), 6.95 (dd, J=15.6, 8.7 Hz, 1H), 6.76 (d, J=15.9 Hz, 1H), 4.67-4.61 (m, 1H), 2.25 (s, 3H); ESIMS m/z 415.0 ([M−H]−); IR (thin film) 3435, 2989, 1700, 1260 cm−1.
(E)-4-(3-(3,5-Dichlorophenyl)-4,4,5,5,5-pentafluoropent-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated as a brown semi solid: 1H NMR (400 MHz, DMSO-d6) δ 13.70 (bs, 1H), 8.01 (s, 1H), 7.91 (s, 1H), 7.80 (d, J=8.4 Hz, 1H), 7.72 (J=1.6 Hz, 2H), 7.66 (t, J=3.2 Hz, 1H), 7.15 (dd, J=15.6, 9.6 Hz, 1H), 6.91 (d, J=15.6 Hz, 1H), 4.86-4.78 (m, 1H); ESIMS m/z 491.0 ([M−H]−); IR (thin film) 3446, 1712, 1141, 749 cm−1.
(E)-2-Bromo-4-(3-(3,5-dichlorophenyl)-4,4,5,5,5-pentafluoropent-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (400 MHz, DMSO-d6) δ 7.85 (s, 1H), 7.70 (s, 2H), 7.65-7.64 (m, 1H), 7.56-7.52 (m, 2H), 6.94 (d, J=9.2 Hz, 1H), 6.76 (d, J=16 Hz, 1H), 4.82-4.80 (m, 1H); ESIMS m/z 500.8 ([M−H]−); IR (thin film) 3422, 1683, 1184, 750, 575 cm−1.
(E)-4-(3-(3,4-Dibromophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(trifluoromethyl)benzoic acid 




The title molecule was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) δ 13.5 (bs, 1H), 8.01-7.99 (m, 2H), 7.94-7.91 (m, 1H), 7.85-7.78 (m, 2H), 7.53-7.50 (m, 1H), 7.09 (dd, J=15.6, 8.7 Hz, 1H), 6.89 (d, J=15.9 Hz, 1H), 4.85-4.78 (m, 1H); ESIMS m/z 528.8 ([M−H]−); IR (thin film) 3437, 1722, 1168 cm−1.
(E)-2-Bromo-4-(3-(3,4-dibromophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) δ 13.38 (bs, 1H), 7.98-7.96 (m, 2H), 7.84 (d, J=8.4 Hz, 1H), 7.74 (d, J=8.1 Hz, 1H), 7.63-7.61 (m, 1H), 7.51-7.49 (m, 1H), 7.01 (dd, J=15.9, 9.0 Hz, 1H), 6.78 (d, J=15.6 Hz, 1H), 4.82-4.76 (m, 1H); ESIMS m/z 538.8 ([M−H]−); IR (thin film) 3446, 1699, 1166, 581 cm−1.
(E)-4-(4,4,4-Trifluoro-3-(3-(trifluoromethoxy)phenyl)but-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated as a brown semi solid: 1H NMR (300 MHz, DMSO-d6) δ 8.01(s, 1H), 7.94 (d, J=8.7 Hz, 1H), 7.80 (d, J=8.1 Hz, 1H), 7.63-7.55 (m, 3H), 7.41 (d, J=7.5 Hz, 1H), 7.11 (dd, J=15.6, 9.0 Hz, 1H), 6.92 (d, J=15.9 Hz, 1H), 4.89-4.82 (m, 1H); ESIMS m/z 456.98 ([M−H]−); IR (thin film) 3413, 1668, 1161 cm−1.
(E)-2-Bromo-4-(4,4,4-trifluoro-3-(3-(trifluoromethoxy)phenyl)but-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown solid: 1H NMR (300 MHz, DMSO-d6) δ 7.73 (s, 1H), 7.59 (m, 3H), 7.44 (s, 1H), 7.40 (d, J=7.6 Hz, 2H), 6.88 (dd, J=15.6, 9.0 Hz, 1H), 6.73 (d, J=15.9 Hz, 1H), 4.85-4.82 (m, 1H); ESIMS m/z 466.93 ([M−H]−); IR (thin film) 3437, 1703, 1111 cm−1.
(E)-4-(3-(3-Cyano-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated as a brown liquid: 1H NMR (300 MHz, DMSO-d6) δ 13.60 (bs, 1H), 8.21-8.19 (m, 1H), 8.01-7.91 (m, 3H), 7.81 (d, J=8.4 Hz, 1H), 7.12 (dd, J=15.9, 8.1 Hz, 1H), 6.91 (d, J=15.6 Hz, 1H), 4.92-4.86 (m, 1H); ESIMS m/z 416.27 ([M−H]−); IR (thin film) 3429, 2238, 1713, 1116 cm−1.
(E)-2-Bromo-4-(3-(3-cyano-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) δ 13.56 (bs, 1H), 8.21-8.18 (m, 1H), 8.00-7.95(m, 2H), 7.73-7.59 (m, 3H), 7.03 (dd, J=15.9, 9.3 Hz, 1H), 6.79 (d, J=15.3 Hz, 1H), 4.87-4.84 (m, 1H); ESIMS m/z 426.0 ([M−H]−)
(E)-2-Bromo-4-(3-(3,4-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) δ 13.4 (s, 1H), 7.96 (d, J=1.2 Hz, 1H), 7.88 (d, J=1.8 Hz, 1H), 7.74-7.68 (m, 2H), 7.63 (dd, J=8.1, 1.2 Hz, 1H), 7.57 (dd, J=8.4, 1.8 Hz, 1H), 7.02 (dd, J=15.9, 9.3 Hz, 1H), 6.78 (dd, J=5.9 Hz, 1H), 4.84-4.78 (m, 1H); ESIMS m/z 451.0 ([M−H]−); IR (thin film) 3445, 1704, 1113, 740 cm−1.
(E)-4-(3-(3-Bromo-5-chlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated as a brown solid: 1H NMR (300 MHz, DMSO-d6) δ 13.50 (bs, 1H), 7.91 (s, 1H), 7.86-7.64 (m, 5H), 7.06 (dd, J=15.9, 9.0 Hz, 1H), 6.87 (d, J=15.9 Hz, 1H), 4.85-4.78 (m, 1H); ESIMS m/z 485.17 ([M−H]−); IR (thin film) 3438, 1708, 1114, 774, 516 cm−1.
(E)-2-Bromo-4-(3-(3-bromo-5-chlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) δ 13.38 (bs, 1H), 7.98 (s, 1H), 7.80-7.72 (m, 4H), 7.64-7.61 (m, 1H), 7.06 (dd, J=15.9, 9.3 Hz, 1H), 6.79 (d, J=15.6 Hz, 1H), 4.88-4.80 (m, 1H); ESIMS m/z 495.05 ([M−H]−); IR (thin film) 3436, 1699, 1116, 750, 531 cm−1.
(E)-4-(3-(3-Bromo-5-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated as a brown liquid: 1H NMR (300 MHz, DMSO-d6) δ 13.6 (bs, 1H), 8.02 (s, 1H), 7.91-7.89 (m, 1H), 7.81 (d, J=8.0 Hz, 1H), 7.69 (s, 1H), 7.63-7.59 (m, 1H), 7.55 (d, J=9.3 Hz, 1H), 7.11 (dd, J=15.9, 9.0 Hz, 1H), 6.91 (d, J=15.9 Hz, 1H), 4.87-4.80 (m, 1H); ESIMS m/z 469.07 ([M−H]−); IR (thin film) 3428, 1712, 1171, 523 cm−1.
(E)-4-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzoic acid




The title molecule was isolated as a yellow solid: 1H NMR (400 MHz, CDCl3) δ 8.18-8.03 (m, 2H), 7.49 (d, J=8.3 Hz, 2H), 7.42 (s, 2H), 6.66 (d, J=15.9 Hz, 1H), 6.47 (dd, J=15.9, 8.0 Hz, 1H), 4.13 (p, J=8.6 Hz, 1H); 19F NMR (376 MHz, CDCl3) δ −68.65; ESIMS m/z 409.1 ([M−H]−).
(E)-2-Bromo-4-(3-(3-chloro-4-methylphenyl)-4,4,4-trifluorobut-1-en-1-yl)benzoic acid 




The title molecule was isolated as a brown liquid: 1H NMR (300 MHz, DMSO-d6) δ 13.30 (bs, 1H), 7.93 (d, J=1.2 Hz, 1H), 7.42 (d, J=8.1 Hz, 1H), 7.62 (dd, J=1.5, 8.1 Hz, 1H), 7.53 (s, 1H), 7.48 (d, J=7.8 Hz, 1H), 7.39 (d, J=7.8 Hz, 1H), 6.96 (dd, J=15.6, 8.7 Hz, 1H), 6.77 (d, J=15.6 Hz, 1H), 4.73-4.61 (m, 1H), 2.35 (s, 3H); ESIMS m/z 431.77 ([M−H]−); IR (thin film) 3435, 1701, 1111, 750 cm−1.
(E)-4-(3-(3-Chloro-4-methylphenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) δ 13.50 (bs, 1H), 7.98 (s, 1H), 7.92 (d, J=8.1 Hz, 1H), 7.80 (d, J=8.1 Hz, 1H), 7.53 (s, 1H), 7.48 (d, J=8.1 Hz, 1H), 7.40 (d, J=8.4 Hz, 1H), 7.04 (dd, J=15.6, 8.4 Hz, 1H), 6.88 (d, J=15.6 Hz, 1H), 4.72-4.66 (m, 1H), 2.35 (s, 3H); ESIMS m/z 421.82 ([M−H]−); IR (thin film) 3460, 2926, 1712, 1170, 750 cm−1.
(E)-4-(4,4,5,5,5-Pentafluoro-3-(3,4,5-trichlorophenyl)pent-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated as a dark brown gum: 1H NMR (300 MHz, DMSO-d6) δ 13.6 (bs, 1H), 8.03 (s, 1H), 7.95-7.86 (m, 3H), 7.81 (d, J=8.1 Hz, 1H), 7.16 (dd, J=15.3, 9.3 Hz, 1H), 6.92 (d, J=15.6 Hz, 1H), 4.95-4.88 (m, 1H); 19F NMR (300 MHz, DMSO-d6) δ −80.35, −58.02; ESIMS m/z 526.8 ([M+H]+).
(E)-2-Bromo-4-(4,4,5,5,5-pentafluoro-3-(3,4,5-trichlorophenyl)pent-1-en-1-yl)benzoic acid




The title molecule was isolated as a dark brown gum: 1H NMR (300 MHz, DMSO-d6) δ 13.6 (bs, 1H), 7.94 (s, 2H), 7.78 (d, J=7.8 Hz, 1H), 7.71 (d, J=7.8 Hz, 1H), 7.60 (d, J=7.5 Hz 1H), 7.07 (dd, J=15.0, 8.7 Hz, 1H), 6.79 (d, J=15.6 Hz, 1H), 4.93-4.78 (m, 1H); ESIMS m/z 538.9 ([M+H]+); IR (thinfilm) 3420, 1602, 1123, 746 cm−1.
(E)-2-Bromo-4-(3-(4-cyano-3,5-difluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown gum: ESIMS m/z 443.91 ([M−H]−); IR (thin film) 3447, 2244, 1703, 1114 cm−1.
(E)-2-Chloro-4-(3-(3,5-dibromophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown liquid: 1H NMR (300 MHz, DMSO-d6) δ 13.39 (bs, 1H), 7.95-7.70 (m, 5H), 7.61 (d, J=8.1 Hz, 1H), 7.07 (dd, J=15.6, 9.3 Hz, 1H), 6.80 (d, J=15.6 Hz, 1H), 4.84-4.78 (m, 1H); ESIMS m/z 496.77 ([M−H]−); IR (thin film) 3439, 2920, 1707, 1165 cm−1.
(E)-4-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated as an off white solid: mp 140-143° C.; 1H NMR (400 MHz, DMSO) δ 3.60 (bs, 1H), 8.02 (s, 1H), 7.94-7.90 (m, 1H), 7.88-7.86 (m, 2H), 7.81-7.79 (m, 1H), 7.12 (dd, J=15.6, 8.8 Hz, 1H), 6.89 (d, J=15.6 Hz, 1H), 4.86-4.81 (m, 2H); ESIMS m/z 458.88 ([M−H]−).
(E)-4-(3-(3,4-Dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzoic acid




The title molecule was isolated as a light orange crystalline solid (875 mg, 88%): 1H NMR (400 MHz, CDCl3) δ 12.35 (s, 1H), 8.08 (d, J=8.4 Hz, 2H), 7.55-7.41 (m, 4H), 7.24 (dd, J=8.3, 2.1 Hz, 1H), 6.64 (d, J=15.8 Hz, 1H), 6.51 (dd, J=15.9, 7.7 Hz, 1H), 4.15 (p, J=8.7 Hz, 1H); 19F NMR 376 MHz, CDCl3) δ −68.75; ESIMS m/z 375 ([M+H]+).
(E)-4-(3-(3,4-Dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated was isolated as a brown gum: 1H NMR (400 MHz, DMSO-d6) δ 13.6 (s, 1H), 8.02 (s, 1H), 7.93-7.89 (m, 2H), 7.80 (d, J=7.6 Hz, 1H), 7.73 (d, J=8.4, Hz, 1H), 7.58 (dd, J=8.4, 2.0 Hz, 1H), 7.09 (dd, J=15.6, 8.8, Hz, 1H), 6.89 (d, J=15.6, Hz, 1H), 4.86-4.81 (m, 1H); ESIMS m/z 441.0 ([M−H]−); IR (thinfilm) 3447, 1710, 1169, 749 cm−1.
(E)-4-(3-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) δ 13.6 (bs, 1H), 7.98 (s, 1H), 7.91 (d, J=7.8 Hz 1H), 7.75-7.66 (m, 1H), 7.10 (dd, J=15.6, 9.0 Hz, 1H), 6.89 (d, J=15.9 Hz 1H), 4.86-4.80 (m, 1H); ESIMS m/z 441.1 ([M−H]−); IR (thinfilm) 3460, 2928, 1721, 1170, 764 cm−1.
(E)-4-(3-(3,4-Dichloro-5-methylphenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated as a pale yellow semi solid: 1H NMR (400 MHz, DMSO-d6) δ 13.58 (bs, 1H), 8.00 (s, 1H), 7.93 (d, J=8.4 Hz, 1H), 7.80 (d, J=8.4 Hz, 1H), 7.72 (s, 1H), 7.55 (s, 1H), 7.07 (dd, J=16.4, 9.6 Hz, 1H), 6.89 (d, J=15.6 Hz, 1H), 4.78-4.73 (m, 1H), 2.42 (s, 3H); ESIMS m/z 455.0 ([M−H]−); IR (thin film) 1713, 1170, 750 cm−1.
(E)-2-Bromo-4-(3-(3,4-dichlorophenyl)-4,4-difluoropent-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (400 MHz, DMSO-d6) δ 13.3 (s, 1H), 7.92 (s, 1H), 7.77-7.71 (m, 2H), 7.68-7.63 (m, 1H), 7.61-7.60 (m, 1H), 7.60-7.58 (m, 1H), 6.98 (dd, J=15.6, 9.2 Hz, 1H), 6.65 (d, J=15.6 Hz, 1H), 4.83-4.80 (m, 1H), 1.59-1.54 (m, 3H); ESIMS m/z 448.8 ([M−H]−).
(E)-2-Bromo-4-(3-(3-chloro-5-ethylphenyl)-4,4,4-trifluorobut-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown liquid: 1H NMR (400 MHz, DMSO-d6) δ 13.4 (bs, 1H), 7.97 (s, 2H), 7.91 (s, 1H), 7.74 (d, J=8.4 Hz, 2H), 7.66-7.61 (m, 1H), 7.03 (dd, J=16.0, 8.4 Hz, 1H), 6.8 (d, J=15.6 Hz, 1H), 4.89-4.84 (m, 1H), 2.66-2.65 (m, 2H), 1.25 (t, J=9.2 Hz, 3H); ESIMS m/z 446.8 ([M+H]+).
(E)-2,6-Dimethyl-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) δ 13.1 (s, 1H), 7.87 (s, 2H), 7.27 (s, 2H), 6.81 (dd, J=15.6, 8.7 Hz, 1H), 6.69 (d, J=15.3 Hz, 1H), 4.85-4.79 (m, 1H), 2.27 (s, 6H); ESIMS m/z 437.01 ([M−H]−); IR (thin film) 3285, 1621, 1162, 954 cm−1.
(E)-2-Bromo-4-(3-(3,5-dibromo-4-chlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) δ 13.40 (bs, 1H), 8.07 (d, J=7.5 Hz, 1H), 7.94-7.89 (m, 2H), 7.66-7.60 (m, 2H), 7.10 (dd, J=8.7, 16.0 Hz, 1H), 6.96 (d, J=15.6 Hz, 1H), 4.82-4.80 (m, 1H); ESIMS m/z 574.7 ([M+H]+).
(E)-4-(3-(3,5-Dibromo-4-chlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) δ 13.36 (bs, 1H) 8.05 (s, 2H), 7.95 (d, J=8.1 Hz, 1H), 7.87-7.67 (m, 2H), 7.14 (dd, J=9.0, 15.6 Hz, 1H), 6.96 (d, J=15.6 Hz, 1H), 4.88-4.82 (m, 1H); ESIMS m/z 564.58 ([M+H]+).
(E)-2-Bromo-4-(3-(4-bromo-3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) δ 13.40 (bs, 1H), 7.98 (s, 1H), 7.87 (s, 2H), 7.75 (d, J=8.1 Hz, 1H), 7.65-7.62 (m, 1H), 7.06 (dd, J=15.9, 9.3 Hz, 1H), 6.80 (d, J=15.9 Hz, 1H), 4.87-4.80 (m, 1H); ESIMS m/z 518.9 ([M−H]−).
(E)-4-(3-(4-Bromo-3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(trifluoromethyl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (300 MHz, DMSO-d6) δ 13.6 (bs, 1H) 8.03 (s, 1H), 7.95 (d, J=8.4 Hz, 1H), 7.88 (s, 2H), 7.81 (d, J=8.1 Hz, 1H), 7.13 (dd, J=16.2, 7.5 Hz, 1H), 6.91 (d, J=15.9 Hz, 1H), 4.89-4.83 (m, 1H); ESIMS m/z 532.0 ([M+H]+).
(E)-2-Bromo-4-(3-(3-chloro-4-(trifluoromethoxy)phenyl)-4,4,4-trifluorobut-1-en-1-yl)benzoic acid




The title molecule was isolated as a brown gum: 1H NMR (400 MHz, DMSO-d6) δ 13.36 (bs, 1H) 7.95 (s, 1H), 7.73 (d, J=7.6 Hz, 1H), 7.63 (d, J=8.1 Hz, 1H), 7.46 (s, 1H) 7.35-7.31 (m, 2H), 7.04 (dd, J=16.0, 8.8 Hz, 1H), 6.78 (d, J=16.4 Hz, 1H), 4.71-4.68 (m, 1H); ESIMS m/z 500.8 ([M−H]−).
Example 20
Preparation of 5-vinyl-2,3-dihydro-1H-inden-1-one (BI1)




To a stirred solution of 5-bromo-2,3-dihydro-1H-inden-1-one (5 g, 23.7 mmol) in toluene were added vinylboronic anhydride pyridine complex (8.55 g, 35.54 mmol), Pd(PPh3)4 (0.1 g, 0.094 mmol), K2CO3 (22.88 g, 165.83 mmol). The resultant reaction mixture was heated at reflux for 16 h. The reaction mixture was cooled to 25° C. and filtered, and the filtrate was concentrated under reduced pressure. The residue was diluted with EtOAc and washed with water and brine. The combined organic extracts were dried over anhydrous Na2SO4 and concentrated under reduced pressure. The obtained residue was purified by flash column chromatography (SiO2, 5% EtOAc in petroleum ether) afforded the title compound as a solid (1.8 g, 48%): 1H NMR (400 MHz, CDCl3) δ 7.74 (d, J=7.2 Hz, 1H), 7.49 (br s, 1H), 7.44 (d, J=7.2 Hz, 1H), 6.82 (m, 1H), 5.90 (d, J=7.4 Hz, 1H), 5.42 (d, J=6.4 Hz, 1H), 3.20 (m, 2H), 2.70 (m, 2H); ESIMS m/z 159.06 ([M+H]−).
The following compound was made in accordance with the procedures disclosed in Example 20.
6-Vinyl-3,4-dihydronaphthalen-1(2H)-one (BI2)




The product was isolated as an off-white solid (5 g, 48%): 1H NMR (400 MHz, DMSO-d6) δ 7.85 (d, J=8.4 Hz, 1H), 7.48 (m, 2H), 6.82 (m, 1H), 6.02 (d, J=7.4 Hz, 1H), 5.44 (d, J=6.4 Hz, 1H), 2.95 (m, 2H), 2.60 (m, 2H), 2.00 (m, 2H); ESIMS m/z 173.14 ([M−H]−); IR (thin film) 1681 cm−1.
Example 21
Preparation of (E)-5-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-2,3-dihydro-1H-inden-1-one (BI3)




5-(1-Bromo-2,2,2-trifluoroethyl)-1,2,3-trichlorobenzene (4 g, 11.7 mmol), 5-vinyl-2,3-dihydro-1H-inden-1-one (0.92 g, 5.8 mmol), CuCl (0.115 g, 1.171 mmol) and 2,2-bipyridyl (0.053 g, 0.34 mmol) in 1,2-dichlorobenzene (25 mL) were heated at 180° C. for 16 h. The reaction mixture was cooled to 25° C. and concentrated under reduced pressure. The residue was purified by flash column chromatography (SiO2, 5% EtOAc in petroleum ether) to afford the title compound as a liquid (1.28 g, 25%): 1H NMR (400 MHz, CDCl3) δ 7.76 (d, J=7.4 Hz, 1H), 7.52 (m, 3H), 6.68 (d, J=7.4 Hz, 1H), 6.52 (m, 1H), 4.18 (m, 1H), 3.18 (m, 2H), 2.75 (m, 2H); ESIMS m/z 419.14 ([M+H]−); IR (thin film) 1708.94, 1113.60, 807.77 cm−1.
The following compound was made in accordance with the procedures disclosed in Example 21.
(E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2,3-dihydro-1H-inden-1-one (BI4)




The product was isolated as a brown semi-solid (1.2 g, 16%): 1H NMR (400 MHz, CDCl3) δ 7.76 (d, J=7.4 Hz, 1H), 7.54 (m, 3H), 7.30 (s, 1H), 6.68 (d, J=7.4 Hz, 1H), 6.52 (m, 1H), 4.18 (m, 1H), 3.18 (m, 2H), 2.75 (m, 2H); ESIMS m/z 400.84 ([M−H]−); IR (thin film) 815, 1113, 1709 cm−1.
(E)-6-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-3,4-dihydronaphthalen-1(2H)-one (BI5) 




The product was isolated as a pale yellow semi solid (1.2 g, 30%): 1H NMR (400 MHz, CDCl3) δ 8.20 (d, J=8.0 Hz, 1H), 7.42 (s, 2H), 7.35 (m, 1H), 7.24 (m, 2H), 6.62 (d, J=16 Hz, 1H), 6.46 (m, 1H), 4.18 (m, 1H), 2.95 (m, 2H), 2.65 (m, 2H), 2.19 (m, 2H); ESIMS m/z 432.94 ([M−H]−); IR (thin film) 1680, 1113, 808 cm−1.
Example 22
Preparation of (E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-fluoro-2,3-dihydro-1H-inden-1-one (BI6)




To a stirred solution of (E)-5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-2,3-dihydro-1H-inden-1-one (0.5 g, 1.24 mmol) in MeCN (20 mL), was added Selectfluor® (0.52 g, 1.48 mmol) and the reaction was heated to reflux temperature for 16 h. The reaction mixture was cooled to room temperature, concentrated under reduced pressure and diluted with CH2Cl2. The solution was washed with water and brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give the crude product which was purified by flash column chromatography (SiO2, 100-200 mesh; 15% EtOAc in petroleum ether) to afford the title compound as a pale yellow semi solid (0.1 g, 24%): 1H NMR (400 MHz, CDCl3) δ 7.80 (m, 1H), 7.48 (m, 2H), 7.32 (m, 2H), 6.65 (d, J=16.0 Hz, 1H), 6.54 (dd, J=16.0, 8.0 Hz, 1H), 5.38 (m, 1H), 4.18 (m, 1H), 3.62 (m, 1H), 3.32 (m, 1H); ESIMS m/z 419.06 ([M−H]−); IR (thin film) 1728, 1114, 817 cm−1.
Example 23
Preparation of (E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-N-(3,3,3-trifluoropropyl)-2,3-dihydro-1H-inden-1-amine (BC10)




To a stirred solution of (E)-5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-2,3-dihydro-1H-inden-1-one (0.15 g, 0.35 mmol) in DCE (10 mL), was added trifluoropropyl amine (0.048 g, 0.42 mmol) and NaBH3CN (0.055 g, 0.875 mmol) in cooling and the reaction mixture was stirred at room temperature for 16 h. The reaction mixture was diluted with DCE, was washed with water and brine and dried over anhydrous Na2SO4. Concentration under reduced pressure gave the crude compound, which was purified by flash column chromatography (SiO2, 100-200 mesh; 10-15% EtOAc in petroleum ether) to afford the title compound as a colorless gummy material (0.042 g, 24%): 1H NMR (400 MHz, CDCl3) δ 7.38-7.20 (m, 5H), 6.62 (d, J=16.0 Hz, 1H), 6.34 (dd, J=16.0, 8.0 Hz, 1H), 5.83 (br, 1H), 5.52 (m, 1H), 4.12 (m, 1H), 3.02 (m, 3H), 2.82 (m, 1H), 2.50 (m, 2H), 1.82 (m, 1H), 1.42 (m, 1H); ESIMS m/z 497.98 ([M−H]−); IR (thin film) 3027, 1654, 815 cm−1.
Example 24
Preparation of 6-((E)-4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-3,4-dihydronaphthalen-1(2H)-one oxime (BI5a)




To a stirred solution of ((E)-6-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-3,4-dihydronaphthalen-1(2H)-one (0.4 g, 0.92 mmol) in EtOH (50 mL) were added hydroxylamine hydrochloride (0.128 g, 1.85 mmol) and sodium acetate (NaOAc, 0.23 g, 2.77 mmol), and the reaction mixture was heated at reflux for 3 h. The reaction mixture was concentrated under reduced pressure, and the residue was diluted with water and extracted with EtOAc. The combined organic extracts were washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give the crude compound, which was purified by flash column chromatography (SiO2, 100-200 mesh; 10-15% EtOAc in petroleum ether). The title compound was isolated as a solid (0.3 g, 73%): mp 155-158° C.; 1H NMR (400 MHz, CDCl3) δ 7.89 (d, J=8.4 Hz, 1H), 7.41 (s, 2H), 7.24 (m, 1H), 7.17 (m, 1H), 6.57 (d, J=16 Hz, 1H), 6.46 (dd, J=16.0, 8.0 Hz, 1H), 4.13 (m, 1H), 2.82 (m, 4H), 2.04 (m, 2H); ESIMS m/z 445.95 ([M−H]−).
Example 25
Preparation of (E)-5-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-2,3-dihydro-1H-inden-1-amine (BI5b)




To a stirred solution of (E)-5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-2,3-dihydro-1H-inden-1-one (1 g, 2.39 mmol) in MeOH (10 mL) were added ammonium acetate (NH4OAc, 1.84 g, 23.9 mmol) and NaBH3CN (0.44 g, 7.17 mmol,) and the reaction mixture was heated at reflux for 16 h. The reaction mixture was concentrated under reduced pressure, and the residue was diluted with water and extracted with EtOAc. The combined organic extracts were washed with water and saturated aqueous NaHCO3 solution, dried over anhydrous Na2SO4, and concentrated under reduced pressure to afford the title compound as a liquid (500 mg, crude): 1H NMR (400 MHz, DMSO-d6) δ 7.85 (s, 2H), 7.40 (s, 1H), 7.30 (s, 2H), 6.71 (s, 2H), 4.78 (m, 1H), 4.2 (m, 1H), 2.80 (m, 1H), 2.73 (m, 1H), 1.60 (m, 2H); ESIMS m/z 419.02 ([M+H]+); IR (thin film) 2924, 1552, 1112, 807 cm−1.
The following compound was made in accordance with the procedures disclosed in Example 25.
(E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2,3-dihydro-1H-inden-1-amine (BI7)




The product was isolated as a light brown gummy material, taken as such to the next step (0.15 g, crude compound): ESIMS m/z 401.97 ([M−H]−).
(E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-fluoro-2,3-dihydro-1H-inden-1-amine (BI8)




The product was isolated as a light brown gummy material, taken as such to the next step (0.15 g, crude compound): ESIMS m/z 420.15 ([M−H]−).
(E)-6-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-1,2,3,4-tetrahydronaphthalen-1-amine (BI9) 




The product was isolated as a pale yellow liquid (500 mg crude).
Example 26
Preparation of (E)-1-Methyl-3-(5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)-but-1-enyl)-2,3-dihydro-1H-inden-1-yl)thiourea (BC1)




To a stirred solution of (E)-5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-2,3-dihydro-1H-inden-1-amine (0.1 g, 0.23 mmol) in Et2O (5 mL) was added methylisothiocyanate (0.026 g, 0.35 mmol), and the mixture was stirred for 2 h at 25° C. The reaction mixture was concentrated under reduced pressure, and the residue was purified by flash column chromatography (SiO2, 20% EtOAc in petroleum ether). The title compound was isolated as a liquid (65 mg, 50%): 1H NMR (400 MHz, CDCl3) δ 7.39 (s, 2H), 7.25-7.18 (m, 3H), 6.58 (d, J=16.0 Hz, 1H), 6.30 (dd, J=16.0, 8.4 Hz, 1H), 5.91-5.70 (br, 2H), 4.05 (m, 1H), 3.05-2.80 (m, 6H), 2.70 (m, 1H), 1.81 (m, 1H); ESIMS m/z 492.17 ([M+H]+); IR (thin film) 3211, 1569, 1113, 806 cm−1.
Compounds BC2-BC3 in Table 1 were made in accordance with the procedures disclosed in Example 26.
Example 27
Preparation of (E)-3,3,3-Trifluoro-N-(5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-2,3-dihydro-1H-inden-1-yl)propanamide (BC4)




To a stirred solution of (E)-5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-2,3-dihydro-1H-inden-1-amine (0.1 g, 0.23 mmol) in CH2Cl2 (10 mL) were added trifluoropropionic acid (0.044 g, 0.34 mmol), EDC.HCl (0.038 g, 0.35 mmol), HOBt.H2O (0.07 g, 0.46 mmol) and DIPEA (0.074 g, 0.57 mmol), and the reaction mixture was stirred for 16 h at 25° C. The reaction mixture was diluted with CH2Cl2 and washed with water. The combined organic layer was washed with brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure. The crude material was purified by flash column chromatography (SiO2, 15% EtOAc in petroleum ether) to afford the title compound as a liquid (65 mg, 65%): 1H NMR (400 MHz, CDCl3) δ 7.39 (s, 2H), 7.25-7.20 (m, 3H), 6.34 (d, J=16.0 Hz, 1H), 6.30 (dd, J=16.0, 8.0 Hz, 1H), 5.81 (br, 1H), 5.48 (m, 1H), 4.10 (m, 1H), 3.10 (m, 2H), 2.86-3.07 (m, 2H), 2.86 (m, 1H), 1.81 (m, 1H); ESIMS m/z 529.02 ([M+H]+); IR (thin film) 3283, 1652, 1241, 811 cm−1.
Compounds BC5-BC9, BC11 in Table 1 were made in accordance with the procedures disclosed in Example 27.
Example 28
Preparation of tert-Butyl 5-vinylindoline-1-carboxylate (BI10)




Step 1. 5-Bromo-indoline (BI11): To 5-Bromo-1H-indole (2.5 g, 12.82 mmol) in AcOH (10.0 mL), NaBH3CN (2.38 g, 38.46 mmol) was added portion wise at 10° C. over the period of 20 min. After that the reaction mixture was stirred at ambient temperature for 3 h. The reaction mixture was diluted with water and extracted with Et2O. The organic layer was washed with saturated NaHCO3, water and brine solution. The combined ether layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford title compound as a pale yellow semi-solid (1.8 g, 71%).
Step 2. tert-Butyl-5-bromoindoline-1-carboxylate (BI12): To a stirred solution of 5-bromo-indoline (3.0 g, 15 mmol) in MeCN (100 ml), was added DMAP (0.185 g, 1.522 mmol) and di-tert-butyl dicarbonate (3.98 g, 18.3 mmol) and the reaction was stirred at ambient temperature for 16 h. The reaction mixture was concentrated on reduced pressure to obtain a residue which was diluted with Et2O and washed with water and brine solution (2×). The combined ether layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the crude product as an off-white solid, which was used in the next step without further purification (3.0 g).
Step 3. tert-Butyl-5-vinylindoline-1-carboxylate (BI10): A stirred solution of ten-butyl-5-bromoindoline-1-carboxylate (2.0 g, 6.73 mmol), potassium vinyl trifluoroborate (2.6 g, 20.20 mmol) and K2CO3 (2.78 g, 20.2 mmol) in DMSO (50.0 mL) was degassed with argon for 20 min at ambient temperature. PdCl2(dppf) (0.49 g, 0.67 mmol) was added at ambient temperature, then the reaction mixture was heated to 100° C. for 3 h. The reaction mixture was cooled to ambient temperature and filtered through a Celite® bed under vacuum and washed with Et2O. The reaction mixture was extracted with Et2O. The combined Et2O layer was dried over Na2SO4 and concentrated under reduced pressure to afford crude product. The crude compound was purified by column chromatography (SiO2, 100-200 mesh; eluting with 2% EtOAc/petroleum ether) to afford the title compound as an off-white solid (1.2 g, 73%): mp 85.5-88.6° C.; 1H NMR (400 MHz, CDCl3) δ 7.23 (m, 3H), 6.69 (dd, J=17.4, 10.8 Hz, 1H), 5.64 (d, J=10.5 Hz, 1H), 5.13 (d, J=10.5 Hz, 1H), 4.00 (t, J=9.0 Hz, 2H), 3.10 (t, J=9.0 Hz, 2H), 1.55 (bs, 9H).
Example 29
Preparation of (E)-tert-Butyl 5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)indoline-1-carboxylate (BI13)




To a stirred solution of tert-butyl-5-vinylindoline-1-carboxylate (1.28 g, 5.23 mmol) in 1,2-dichlorobenzene (10.0 mL), was added 5-(1-bromo-2,2,2-trifluoroethyl)-1,3-dichloro-2-fluorobenzene (3.4 g, 10 mmol), CuCl (103 mg, 1.05 mmol) and 2,2-bipyridyl (0.326 g, 2.092 mmol) and the resultant reaction mixture was degassed with argon for 30 min and heated to 150° C. for 1 h. The reaction mixture was cooled to ambient temperature and filtered and the filtrate was concentrated under reduced pressure. The crude compound was purified by column chromatography (SiO2, 100-200 mesh; 2% EtOAc/petroleum ether) to afford the title compound as a pale yellow gummy solid (0.3 g, 61%): 1H NMR (400 MHz, CDCl3) δ 7.34 (d, J=6.0 Hz, 2H), 7.22 (s, 2H), 7.16 (d, J=8.4 Hz, 1H), 6.52 (d, J=16.0 Hz, 1H), 6.21 (dd, J=16.0, 7.6 Hz, 1H), 4.07 (m, 3H), 3.10 (t, J=8.4 Hz, 2H), 1.55 (s, 9H); ESIMS m/z 433.79 ([M−H]−); IR (thin film) 1168, 858 cm−1.
Example 30
Preparation of (E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)indolin-1-amine (BI14)




Step 1. (E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)indoline (BI15) To a stirred solution of (E)-tert-butyl-5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)indoline-1-carboxylate (0.2 g, 0.4 mmol) in CH2Cl2 (10.0 mL) was added TFA (0.6 mL) and the reaction was stirred at ambient temperature for 2 h. The reaction mixture was diluted with CH2Cl2, washed with saturated aq NaHCO3, water and brine solution. The separated CH2Cl2 layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the crude product as a light brown gummy material which was used in the next step without further purification (0.12 g): 1H NMR (400 MHz, CDCl3) δ 7.33 (d, J=6.4 Hz, 2H), 7.21 (s, 1H), 7.02 (d, J=8.0 Hz, 1H), 6.57 (d, J=8.4 Hz, 1H), 6.49 (d, J=15.6 Hz, 1H), 6.21 (dd, J=15.6, 8.4 Hz, 1H), 4.07 (m, 1H), 3.61 (t, J=8.4 Hz, 2H), 3.05 (t, J=8.4 Hz, 2H); ESIMS m/z 389.89 ([M+H]+); IR (thin film) 3385, 1112, 816 cm−1.
Step 2. 5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1-nitrosoindoline (BI16): To (E)-5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)indoline (0.2 g, 0.5 mmol) in concentrated HCl (5.0 ml) at 5° C., was added slowly NaNO2 in water and the reaction was allowed to stir at ambient temperature for 2 h. The reaction mixture was diluted with CH2Cl2, and the CH2Cl2 layer washed with water and brine solution. The separated CH2Cl2 layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the crude product as a pale yellow solid that was used in the next step without further purification (0.2 g): 1H NMR (400 MHz, CDCl3) δ 7.33 (d, J=8.4 Hz, 1H), 7.39 (m, 4H), 6.61 (d, J=16.0 Hz, 1H), 6.35 (dd, J=16.0, 8.4 Hz, 1H), 4.07 (m, 3H), 3.23 (t, J=8.4 Hz, 2H); ESIMS m/z 418.82 ([M+H]+); IR (thin film) 1488, 1112, 860 cm−1.
Step 3. (E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)indolin-1-amine (BI14): To (E)-5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1-nitrosoindoline (0.1 g, 0.2 mmol) in MeOH(10.0 mL) was added zinc powder (77.5 mg) and NH4Cl (36.9 mg, 0.69 mmol) in water (2.0 mL). The reaction mixture was stirred at ambient temperature for 3 h. The reaction mixture was diluted with CH2Cl2 and the CH2Cl2 layer was washed with water and brine solution. The separated CH2Cl2 layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the crude compound, which was purified by column chromatography (SiO2, 100-200 mesh; eluting with 2% EtOAc/petroleum ether) to afford the title compound as a light brown gummy material (0.08 g): ESIMS m/z 404.86 ([M+H]+).
Example 31
Preparation of (E)-N-(5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)indolin-1-yl)-3,3,3-trifluoropropanamide (BC12) 




To a stirred solution of (E)-5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)indoline-1-amine (0.1 g, 0.247 mmol) in CH2Cl2 (10.0 ml) was added 3,3,3-trifluoropropanoic acid (0.038 g, 0.297 mmol), PyBOP (0.192 g, 0.370 mmol) and DIPEA (0.047 g, 0.370 mmol) and the reaction was stirred at ambient temperature for 18 h. The reaction mixture was diluted with CH2Cl2, and the separated CH2Cl2 layer dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the crude compound. The crude compound was purified by column chromatography (SiO2, 100-200 mesh; 20-25% EtOAc/petroleum ether) to afford the title compound as a light brown gummy material (0.12 g, 33%): 1H NMR (400 MHz, CDCl3) δ 7.32, (d, J=6.0 Hz, 2H) 7.28 (m, 1H), 7.20 (d, J=8.0, 1H), 7.14 (d, J=8.8, 1H), 6.70 (d, J=8.0 Hz, 1H), 6.60 (m, 2H), 4.15 (m, 1H), 3.85 (m, 1H), 3.65 (m, 1H), 3.46 (m, 2H), 3.19 (m, 2H); ESIMS m/z 514.86 ([M+H]+); IR (thin film) 3428, 1112, 857 cm−1.
Example 32
Preparation of tert-Butyl-5-vinyl-1H-indole-1-carboxylate (BI17)




Step 1. 5-Vinyl-1H-indole (BI18): A mixture of 5-bromo-1H-indole (2.5 g, 12.82 mmol), potassium vinyltrifluoroborate (2.57 g, 19.2 mmol), Cs2CO3 (12.53 g, 38.46 mmol) and triphenylphosphine (201 mg, 0.769 mmol) in THF/water (9:1, 75 ml) was degassed with argon for 20 min, then charged with PdCl2 (45.3 mg, 0.256 mmol). The reaction mixture was heated to reflux for 16 h, then cooled to ambient temperature, filtered through Celite® bed and washed with EtOAc. The filtrate was again extracted with EtOAc, and the combined organic layer washed with water and brine, dried over Na2SO4 and concentrated under reduced pressure to afford the crude compound. The crude compound was purified by column chromatography (SiO2, 100-200 mesh; 2% EtOAc/petroleum ether) to afford the title compound as a light brown gummy material (1.5 g, 83%): 1H NMR (400 MHz, CDCl3) δ 8.20 (br, 1H), 7.68 (s, 1H), 7.45 (s, 2H), 7.21 (m, 1H), 6.90 (dd, J=16.0, 10.8 Hz, 1H), 6.55 (m, 1H), 5.75 (d, J=10.5 Hz, 1H), 5.21 (d, J=10.5 Hz, 1H); ESIMS m/z 142.05 ([M−H]−).
Step 2. tert-Butyl-5-vinyl-1H-indole-1-carboxylate (BI17): To a stirred solution of 5-vinyl-1H-indole (0.7 g, 4.89 mmol) in MeCN (20 ml) was added DMAP (59.65 mg, 0.489 mmol) and di-tert-butyl dicarbonate (1.38 g, 6.36 mmol), and the reaction was stirred at ambient temperature for 3 h. The reaction mixture was concentrated under reduced pressure to obtain a residue which was diluted with CH2Cl2 and washed with water and brine solution. The combined CH2Cl2 layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the crude compound. The crude compound was purified by column chromatography (SiO2, 100-200 mesh; 2% EtOAc/petroleum ether) to afford the title compound as an off-white semi-solid (0.7 g, 59%): 1H NMR (400 MHz, CDCl3) δ 8.15 (d, J=8.0 Hz, 1H), 7.60 (s, 2H), 7.30 (d, J=8.4 Hz, 1H), 7.21 (m, 1H), 6.90 (dd, J=16.0, 10.8 Hz, 1H), 6.59 (s, 1H), 5.75 (d, J=10.5 Hz, 1H), 5.21 (d, J=10.5 Hz, 1H), 1.65 (s, 9H); ESIMS m/z 242.10 ([M−H]−); IR (thin film) 1630 cm−1.
Example 33
Preparation of (E)-tert-Butyl 5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indole-1-carboxylate (BI19)




To a stirred solution of tert-butyl 5-vinyl-1H-indole-1-carboxylate (0.65 g, 2.67 mmol), in 1,2-dichlorobenzene (10.0 mL) was added 5-(1-bromo-2,2,2-trifluoroethyl)-1,3-dichloro-2-fluorobenzene (1.74 g, 5.37 mmol), CuCl (53 mg, 0.537 mmol) and 2,2-bipyridyl (167 mg, 1.07 mmol). The resultant reaction mixture was degassed with argon for 30 min and heated to 150° C. for 2 h. The reaction mixture was cooled to ambient temperature and filtered, and the filtrate concentrated under reduced pressure. The crude compound was purified by column chromatography (SiO2, 100-200 mesh; 2% EtOAc/petroleum ether) to afford the title compound as a light brown gummy material (0.25 g, 10%): 1H NMR (400 MHz, CDCl3) δ 8.20 (d, J=8.0 Hz, 1H), 7.60 (m, 2H), 7.39 (m, 3H), 6.69 (d, J=16.0 Hz, 1H), 6.55 (d, J=10.5 Hz, 1H), 6.36 (dd, J=16.0, 8.0 Hz, 1H), 4.10 (m, 1H), 1.65 (s, 9H); ESIMS m/z 485.91 ([M−H]−); IR (thin film) 1165, 854 cm−1.
Example 34
Preparation of (E)-5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indole (BI20) 




To a stirred solution of (E)-tert-butyl 5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1H-indole-1-carboxylate (0.2 g, 0.40 mmol) in CH2Cl2 (10.0 mL) was added TFA (70 mg, 0.61 mmol) and the reaction was stirred at ambient temperature for 2 h. The reaction mixture was diluted with CH2Cl2 and washed with saturated NaHCO3 solution, water and brine solution. The separated CH2Cl2 layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the title compound as a light brown solid (0.2 g, 97%): mp 132.9-138.8° C.; 1H NMR (400 MHz, CDCl3) δ 11.19 (br, 1H), 8.20 (d, J=8.0 Hz, 1H), 7.60 (m, 2H), 7.39 (m, 3H), 6.69 (d, J=16.0 Hz, 1H), 6.55 (d, J=10.5 Hz, 1H), 6.36 (dd, J=16.0, 8.0 Hz, 1H), 4.82 (m, 1H); ESIMS m/z 387.98 ([M+H]+).
Example 35
Preparation of 4-Nitrophenyl 2-((tert-butoxycarbonyl)amino)acetate (BI21)




To a stirred solution of 4-nitrophenol (1.0 g, 7.19 mmol) in CH2Cl2 (20.0 mL) was added N-Boc glycine (1.38 g, 7.91 mmol) and EDC HCl (2.05 g, 10.785 mmol) and the reaction was stirred at ambient temperature for 24 h. The reaction mixture was diluted with CH2Cl2 and washed with water and saturated brine solution. The separated CH2Cl2 layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the title compound as a light brown gummy material that was used in the next step without further purification (1.1 g): 1H NMR (400 MHz, CDCl3) δ 8.29 (d, J=9.2 Hz, 2H), 7.33 (d, J=8.8 Hz, 2H), 5.07 (br, 1H), 4.20 (s, 2H), 1.47 (s, 9H); ESIMS m/z 296.27 ([M+H]+).
Example 36
Preparation of (E)-tert-Butyl (2-(5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indol-1-yl)-2-oxoethyl)carbamate (BI22)




To a stirred solution of (E)-5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1H-indole (0.1 g, 0.258 mmol) in MeCN (5.0 mL) was added 4-nitrophenyl 2-(tert-butoxycarbonylamino) acetate (0.114 g, 0.387 mmol), KF (0.03 g, 0.516 mmol), 18-crown-6-ether (0.075 g, 0.283 mmol) and DIPEA (0.0332 g, 0.258 mmol) and the reaction was stirred at ambient temperature for 16 h. The reaction mixture was concentrated to obtain a residue which was diluted with CH2Cl2 and washed with water and brine solution. The separated CH2Cl2 layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the crude title compound as a light brown gummy material which was used in the next step without further purification (0.1 g): ESIMS m/z 545.23 ([M+H]+).
Example 37
Preparation of (E)-N-(2-(5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indol-1-yl)-2-oxoethyl)-3,3,3-trifluoropropanamide (BC13)




Step 1. (E)-2-Amino-1-(5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1H-indol-1-yl)ethanone (BI23): To a stirred solution of (E)-tert-butyl 2-(5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1H-indol-1-yl)-2-oxoethylcarbamate (0.05 g, 0.09 mmol) in CH2Cl2 (5.0 mL) was added TFA (0.01 mL) and the reaction was stirred at ambient temperature for 16 h. The reaction mixture was diluted with CH2Cl2 and washed with saturated NaHCO3 solution, water and brine solution. The separated CH2Cl2 layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the crude title compound which was used in the next step without further purification (50 mg).
Step 2. (E)-N-(2-(5-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1H-indol-1-yl)-2-oxoethyl)-3,3,3-trifluoropropanamide (BC13): To a stirred solution of (E)-2-amino-1-(5-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1H-indol-1-yl) ethanone (0.04 g, 0.09 mmol) in CH2Cl2 (5.0 ml) was added 3,3,3-trifluoropropanoic acid (17.5 mg, 0.136 mmol), PyBOP (70 mg, 0.135 mmol) and DIPEA (29 mg, 0.225 mmol) and the reaction was stirred at ambient temperature for 16 h. The reaction mixture was diluted with CH2Cl2, and the CH2Cl2 layer was washed with water and saturated brine solution. The separated CH2Cl2 layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the crude compound, which was purified by column chromatography (SiO2, 100-200 mesh; 10% EtOAc/petroleum ether) to afford the title compound as an off-white solid (30 mg, 60%): mp 121-126° C.; 1H NMR (400 MHz, CDCl3) δ 8.33 (br, 1H), 7.59 (s, 1H), 7.45 (m, 4H), 6.72 (d, J=3.6 Hz, 3H), 6.39 (m, 1H), 4.71 (t, J=7.2 Hz, 2H), 4.15 (m, 1H), 3.51 (m, 1H), 3.28 (m, 1H); ESIMS m/z 553.06 ([M−H]−).
Example 38
Preparation of Ethyl 2-(1-oxo-6-vinylphthalazin-2(1H)-yl)acetate (BI24) 




Step 1. 5-Bromo-3-hydroxyisoindoline-1-one (BI25): A mixture of Zn powder (1.73 g, 26.154 mmol), copper (II) sulfate pentahydrate (0.02 g, 0.08 mmol) and 2M aq NaOH (27 mL) were cooled to 0° C. 5-Bromoisoindoline-1,3-dione (5 g, 22 mmol) was added at the same temperature over the period of 30 min. The reaction mixture was stirred at 0° C. for 30 min and 3 h at ambient temperature. The reaction mixture was filtered and the filtrate was neutralized with concentrated HCl. The reaction mixture was diluted with ethanol and extracted with EtOAc. The combined EtOAc layer was dried over Na2SO4 and concentrated under reduced pressure to afford the crude title compound as a brown solid, which was used in the next step without further purification (1.3 g): mp 258-261° C.; 1H NMR (400 MHz, DMSO-d6) δ 9.03 (br, 1H), 7.81 (m, 2H), 7.69 (m, 1H), 6.44 (m, 1H), 5.88 (d, J=9.3 Hz, 1H); ESIMS m/z 225.83 ([M−H]−); IR (thin film) 1684, 3246, 606 cm−1.
Step 2. 6-Bromophthalazine-1(2H)-one (BI26): To a stirred solution of 5-bromo-3-hydroxyisoindoline-1-one (1.0 g, 4.40 mmol) in water, was added hydrazine hydrate (0.45 g, 8.80 mmol) and heated to 95° C. for 5 h. The reaction mixture was cooled to ambient temperature, filtered and washed with Et2O and pentane (1:1) to afford the title compound as a white solid that was used in the next step without further purification (0.5 g): ESIMS m/z 225.15 ([M+H]+).
Step 3. 6-Vinylphthalazine-1(2H)-one (BI27): A solution of 6-bromophthalazine-1(2H)-one (0.25 g, 1.11 mmol), potassium vinyl trifluoroborate (0.446 g, 3.33 mmol) and K2CO3 (0.46 g, 3.33 mmol) in DMSO (2 mL) was degassed with argon for 20 min at ambient temperature. PdCl2(dppf) (0.04 g, 0.055 mmol) was added at ambient temperature, and the reaction mixture was heated to 80° C. for 2 h. The reaction mixture was cooled to ambient temperature and filtered through Celite® bed under vacuum and washed with EtOAc. The reaction mixture was extracted with EtOAc and the combined EtOAc layer dried over Na2SO4 and concentrated under reduced pressure to afford the crude product. The crude compound was purified by column chromatography (SiO2, 100-200 mesh; 50% EtOAc/petroleum ether) to afford the title compound as a brown solid (0.12 g, 63%): 1H NMR (400 MHz, DMSO-d6) δ 13.61 (br, 1H), 8.33 (m, 1H), 8.19 (m, 1H), 8.01 (m, 2H), 6.97 (m, 1H), 6.15 (m, 1H), 5.56 (d, J=10.8 Hz, 1H); ESIMS m/z 172.93 ([M+H]+); IR (thin film) 1748, 1655, 3241 cm−1.
Step 4. Ethyl-2-(1-oxo-6-vinylphthalazine-2(1H)-yl acetate (BI24): To a stirred solution of 6-vinylphthalazine-1(2H)-one (0.5 g, 2.90 mmol) in DMF (5.0 mL) was added Cs2CO3 (0.94 g, 2.90 mmol) and the reaction was stirred for 10 min Ethyl bromoacetate (0.48 g, 2.90 mmol) was added to the reaction mixture at ambient temperature and the reaction was stirred for 8 h at ambient temperature. The reaction mixture was diluted and extracted with EtOAc, and the EtOAc layer was washed with water and brine solution (2×). The separated EtOAc layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford crude product. The crude compound was purified by column chromatography (SiO2, 100-200 mesh; 25% EtOAc/petroleum ether) to afford the title compound as a brown solid (0.34 g, 45%): 1H NMR (400 MHz, DMSO-d6) δ 8.45 (m, 1H), 8.24 (m, 1H), 8.04 (m, 2H), 7.01 (m, 1H), 6.17 (d, J=2.1 Hz, 1H), 5.56 (d, J=10.8 Hz, 1H), 4.92 (s, 2H), 4.19 (m, 2H), 1.23 (m, 3H). ESIMS m/z 259.10 ([M+H]+); IR (thin film) 1750, 1660 cm−1.
Example 39
Preparation of (E)-Ethyl 2-(6-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1-oxophthalazin-2(1H)-yl)acetate (BI28)




To a stirred solution of ethyl-2-(1-oxo-6-vinylphthalazine-2(1H)-yl acetate (0.07 g, 0.27 mmol) in 1,2-dichlorobenzene (1.0 mL) was added 5-(1-bromo-2,2,2-trifluoroethyl)-1,3-dichloro-2fluorobenzene (0.17 g, 0.54 mmol), CuCl (0.005 g, 0.05 mmol) and 2,2-bipyridyl (0.016 g, 0.10 mmol) and the resultant reaction mixture was degassed with argon for 30 min and heated to 180° C. for 12 h. The reaction mixture was cooled to ambient temperature and filtered and the filtrated was concentrated under reduced pressure. The crude compound was purified by column chromatography (SiO2, 100-200 mesh; 10-15% EtOAc/petroleum ether) to afford the title compound as a brown solid (40 mg, 29%): 1H NMR (400 MHz, DMSO-d6) δ 8.40 (d, J=8.4 Hz, 1H), 7.84 (d, J=1.5 Hz, 1H), 7.65 (s, 1H), 7.37 (d, J=6.3 Hz, 2H), 6.76 (d, J=16.0 Hz, 1H), 6.59 (dd, J=16.0, 8.0 Hz, 1H), 4.96 (s, 2H), 4.29 (m, 3H), 1.31 (t, J=7.2 Hz, 3H); ESIMS m/z 503.0 ([M+H]+); IR (thin film) 1660, 1114, 817 cm−1.
Example 40
Preparation of (E)-2-(6-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1-oxophthalazin-2(1H)-yl)acetic acid (BI29) 




A solution of (E)-ethyl-2-(6-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1-oxophthalazin-2(1H)-yl)acetate (0.04 g, 0.07 mmol) in HCl (0.5 mL) and AcOH (0.5 mL) was heated to 100° C. for 3 h. The solvent was removed under reduced pressure and the residue diluted with water. The aqueous layer was extracted with EtOAc and the separated EtOAc layer dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the crude compound. The crude compound was triturated with Et2O-pentane mixture to afford the title compound as a brown solid (0.03 g): 1H NMR (400 MHz, DMSO-d6) δ 13.0 (br s, 1H), 8.43 (m, 1H), 8.23 (d, J=8.1 Hz, 1H), 8.14 (m, 2H), 7.91 (m, 2H), 7.16 (dd, J=16.0, 8.0 Hz, 1H), 6.99 (d, J=16.0 Hz, 1H), 4.96 (m, 3H),; ESIMS m/z 473.0 ([M−H]−); IR (thin film) 1629, 1168, 817 cm−1.
Example 41
Preparation of (E)-2-(6-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-1-oxophthalazin-2(1H)-yl)-N-(2,2,2-trifluoroethyl)acetamide (BC14)




To a stirred solution of (E)-2-(6-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-1-oxophthalazin-2(1H)-yl)acetic acid (0.15 g, 0.31 mmol) in CH2Cl2 (20.0 ml) was added 2,2,2,-trifluoroethanamine (0.03 g, 0.31 mmol), PyBOP (0.17 g, 0.34 mmol) and DIPEA (0.15 ml, 0.93 mmol) at ambient temperature, and the reaction was stirred for 18 h. The reaction mixture was diluted with CH2Cl2 and washed with 3N HCl (2×20 mL), NaHCO3 (2×20 mL) and brine solution (2×). The separated CH2Cl2 layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the crude compound. The crude compound was purified by column chromatography (SiO2, 100-200 mesh; 20-25% EtOAc/petroleum ether) to afford the title compound as a brown solid (0.11 g): mp 172-175° C.; 1H NMR (400 MHz, CDCl3) δ 8.83 (t, J=6.6 Hz, 1H), 8.42 (t, J=14.7 Hz, 1H), 8.22 (d, J=8.1 Hz, 1H), 8.13 (t, J=6.3 Hz, 1H), 7.98-7.86 (m, 2H), 7.16-7.07 (m, 1H), 7.01-6.93 (m, 1H), 4.96-4.81 (m, 3H), 4.00-3.88 (m, 2H); ESIMS m/z 554.0 ([M−H]−).
Example 42
Preparation of 2-(4-Vinylbenzyl)isoindoline-1,3-dione (CI1) 




To a stirred solution of 1-(chloromethyl)-4-vinylbenzene (10 g, 66 mmol) in DMF (100 mL) was added potassium phthalimide (13.3 g, 72.1 mmol), and the resultant reaction mixture was heated at 70° C. for 16 h. The reaction mixture was diluted with water and extracted with CHCl3. The combined CHCl3 layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure. Recrystallization from MeOH afforded the title compound as an off-white solid (8 g, 46%): 1H NMR (400 MHz, CDCl3) δ 7.83 (m, 2H), 7.71 (m, 2H), 7.39 (m, 4H), 6.65 (dd, J=17.6, 10.8 Hz, 1H), 5.72 (d, J=17.6 Hz, 1H), 5.21 (d, J=10.8 Hz, 1H), 4.82 (s, 2H); GCMS m/z 263.2 ([M]+); IR (thin film) 3420, 1133, 718 cm−1.
Example 43
Preparation of (E)-2-(4-(3-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzyl)isoindoline-1,3-dione (CI2)




Using the procedure of Example 10 with 2-(4-vinylbenzyl)isoindoline-1,3-dione and 1-(1-bromoethyl)-3,5-dichlorobenzene as the starting materials, the title compound was isolated as an off-white solid (0.3 g, 40-50%): mp 142-145° C.; 1H NMR (400 MHz, CDCl3) δ 7.86 (m, 2H), 7.74 (m, 2H), 7.42 (m, 2H), 7.36 (m, 3H), 7.27 (m, 2H), 6.58 (d, J=16.0 Hz, 1H), 6.32 (dd, J=16.0, 8.0 Hz, 1H), 4.82 (s, 2H), 4.05 (m, 1H); ESIMS m/z 488.17 ([M−H]−).
The following compound was made in accordance with the procedures disclosed in Example 43.
(E)-2-(4-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzyl)isoindoline-1,3-dione (CI3)




The title compound was isolated as an off white solid (0.3 g, 56%): mp 145-146° C.; 1H NMR (400 MHz, CDCl3) δ 7.86 (m, 2H), 7.74 (m, 2H), 7.42-7.31 (m, 6H), 6.58 (d, J=16.0 Hz, 1H), 6.53 (dd, J=16.0, 8.0 Hz, 1H), 4.82 (s, 2H), 4.05 (m, 1H); ESIMS m/z 522.2 ([M−H]−); IR (thin film) 1716, 1110, 712 cm−1.
Prophetically, compounds CI4-CI5 (Table 1) could be made in accordance with the procedures disclosed in Example 43.
Example 44
Preparation of (E)-(4-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)phenyl)methanamine (CI6)




To a stirred solution of (E)-2-(4-(3-(3,5-dichlorophenyl)but-1-en-1-yl)benzyl)-isoindoline-1,3-dione (1.2 g, 2.45 mmol) in EtOH was added hydrazine hydrate (0.61 g, 12 mmol), and the resultant reaction mixture was heated at 90° C. for 1 h. The reaction mixture was filtered, and the filtrate was concentrated. The residue was dissolved in CH2Cl2, washed with brine, dried over Na2SO4, and concentrated under reduced pressure to afford the crude title compound as a gummy liquid (0.9 g) which was used without further purification.
The following compounds were made in accordance with the procedures disclosed in Example 44.
(E)-(4-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)-phenyl)methanamine (CI7)




The title compound was isolated and used without further purification.
Prophetically, compounds CI8-CI9 (Table 1) could be made in accordance with the procedures disclosed in Example 44.
Example 45
Preparation of 4-(Bromomethyl)-3-chlorobenzonitrile (CI10)




To a stirred solution of 3-chloro-4-methylbenzonitrile (5 g, 25.4 mmol) in CCl4 (50 mL) under an argon atmosphere was added NBS (5.16 g, 29 mmol), and the mixture was degassed for 30 min. To this was added AIBN (0.3 g, 1.8 mmol), and the resultant reaction mixture was heated at reflux for 4 h. The reaction mixture was cooled to ambient temperature, washed with water, and extracted with CH2Cl2. The combined CH2Cl2 layer was washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The crude compound was purified by flash column chromatography (SiO2, 100-200 mesh; 5% EtOAc in n-Hexane) to afford the title compound as a white solid (4.8 g, 68%): mp 87-88° C.; 1H NMR (400 MHz, CDCl3) δ 7.71 (s, 1H), 7.59 (s, 2H), 4.60 (s, 2H); ESIMS m/z 229.77 ([M+H]+); IR (thin film) 2235, 752, 621 cm−1.
The following compounds were made in accordance with the procedures disclosed in Example 45.
4-(Bromomethyl)-3-(trifluoromethyl)benzonitrile (CI11)




The title compound was isolated as an off-white gummy material (5 g, 66%): 1H NMR (400 MHz, CDCl3) δ 7.96 (s, 1H), 7.86 (d, J=8.0 Hz, 1H), 7.76 (d, J=8.0 Hz, 1H), 4.62 (s, 2H); ESIMS m/z 262.11 ([M−H]−); IR (thin film) 2236, 1132, 617 cm−1.
3-Bromo-4-(bromomethyl)benzonitrile (CI12)




The title compound was isolated as an off-white solid (5 g, 67%): mp 82-83° C.; 1H NMR (400 MHz, CDCl3) δ 7.90 (s, 1H), 7.61 (m, 2H), 4.62 (s, 2H); EIMS m/z 272.90; IR (thin film) 2229, 618 cm−1.
4-(Bromomethyl)-3-fluorobenzonitrile (CI13)




The title compound was isolated as an off-white solid (2 g, 60%): mp 79-81° C.; 1H NMR (400 MHz, CDCl3) δ 7.54 (t, J=8.0 Hz, 1H), 7.48 (dd, J=8.0 Hz, 8.0, 1H), 7.38 (dd, J=5 Hz, 1H), 4.5 (s, 2H); EIMS m/z 215.
Example 46
Preparation of 4-(Bromomethyl)-3-chlorobenzaldehyde (CI14) 




To a stirred solution of 4-(bromomethyl)-3-chlorobenzonitrile (4.8 g, 17 mmol) in toluene (50 mL) at 0° C. was added dropwise DIBA1-H (1.0 M solution in toluene; 23.9 mL), and the reaction mixture was stirred at 0° C. for 1 h. 10 M HCl in water (5 mL) was added until the reaction mixture turned to a white slurry and then additional 1 N HCl (20 mL) was added. The organic layer was collected and the aqueous layer was extracted with CHCl3. The combined organic layer was dried over Na2SO4 and concentrated under reduced pressure. The crude compound was purified by flash column chromatography (SiO2, 100-200 mesh; 5% EtOAc in n-Hexane) to afford the title compound as a white solid (3.8 g, 80%): mp 64-66° C.; 1H NMR (400 MHz, CDCl3) δ 10.00 (s, 1H), 7.92 (s, 1H), 7.78 (d, J=8.0 Hz, 1H), 7.64 (d, J=8.0 Hz, 1H), 4.60 (s, 2H); ESIMS m/z 232.78 ([M+H]+).
The following compounds were made in accordance with the procedures disclosed in Example 46.
4-(Bromomethyl)-3-(trifluoromethyl)benzaldehyde (CI15)




The title compound was isolated as a pale yellow low-melting solid (5 g, 60%): 1H NMR (400 MHz, CDCl3) δ 10.09 (s, 1H), 8.19 (s, 1H), 8.09 (m, 1H), 7.81 (m, 1H), 4.61 (s, 2H); ESIMS m/z 265.04 ([M−H]−); IR (thin film) 1709, 1126, 649 cm−1.
3-Bromo-4-(bromomethyl)benzaldehyde (CI16)




The title compound was isolated as a pale yellow solid (5 g, 62%): mp 94-95° C.; 1H NMR (400 MHz, CDCl3) δ 9.96 (s, 1H), 8.05 (s, 1H), 7.81 (d, J=8.0 Hz, 1H), 7.62 (d, J=8.0 Hz, 1H), 4.60 (s, 2H); EIMS m/z 275.90 ([M]+).
4-(Bromomethyl)-3-fluorobenzaldehyde (CI17)




The title compound was isolated as an off-white solid (5 g, 61%): mp 43-45° C.; 1H NMR (400 MHz, CDCl3) δ 9.1 (s, 1H), 7.54 (t, J=8 Hz, 1H), 7.48 (d, J=8 Hz, 1H), 7.38 (d, J=5 Hz, 1H), 4.5 (s, 2H); EIMS m/z 216 ([M]+).
Example 47
Preparation of 3-Chloro-4-((1,3-dioxoisoindolin-2-yl)methyl)benzaldehyde (CI18)




To a stirred solution of 4-(bromomethyl)-3-chlorobenzaldehyde (3.8 g, 14 mmol) in DMF (40 mL) was added potassium pthalimide (3.54 g, 19.14 mmol), and the mixture was heated at 60° C. for 6 h. The reaction mixture was cooled to ambient temperature and diluted with water (100 mL). The solid obtained was separated by filtration and dried under vacuum to afford the title compound as a white solid (2.8 g, 60%): mp 123-126° C.; 1H NMR (400 MHz, CDCl3) δ 9.95 (s, 1H), 8.21 (s, 1H), 7.91 (m, 3H), 7.80 (m, 2H), 7.20 (m, 1H), 5.05 (s, 2H); ESIMS m/z 298.03 ([M−H]−).
The following compounds were made in accordance with the procedures disclosed in Example 47.
4-((1,3-Dioxoisoindolin-2-yl)-3-(trifluoromethyl)benzaldehyde (CI19)




The title compound was isolated as an off white solid (1 g, 62%): mp 142-143° C.; 1H NMR (400 MHz, CDCl3) δ 10.05 (s, 1H), 8.15 (s, 1H), 7.91 (m, 2H), 7.80 (m, 3H), 7.27 (m, 1H), 5.19 (s, 2H); ESIMS m/z 332.03 ([M−H]−).
3-Bromo-4-((1,3-dioxoisoindolin-2-yl)methyl)benzaldehyde (CI20) 




The title compound was isolated as an off-white solid (0.5 g, 64%): mp 159-161° C.; 1H NMR (400 MHz, CDCl3) δ 9.95 (s, 1H), 8.21 (s, 1H), 7.91 (m, 3H), 7.80 (m, 2H), 7.20 (m, 1H), 5.05 (s, 2H); ESIMS m/z 314.00 ([M-CHO]−).
4-((1,3-Dioxoisoindolin-2-yl)-3-fluorobenzaldehyde (CI21)




The title compound was isolated as a white solid (2 g, 60%): mp 154-156° C.; 1H NMR (400 MHz, CDCl3) δ 9.95 (s, 1H), 7.9 (m, 2H), 7.75 (m, 2H), 7.6 (m, 2H), 7.5 (t, J=7.6 Hz, 1H), 5.05 (s, 2H); EIMS m/z 283.1 ([M]+).
Example 48
Preparation of 2-(2-Chloro-4-vinylbenzyl)isoindoline-1,3-dione (CI22)




To a stirred solution of 3-chloro-4-((1,3-dioxoisoindolin-2-yl)methyl)benzaldehyde (2.8 g, 8.2 mmol) in 1,4-dioxane (30 mL) were added K2CO3 (1.68 g, 12.24 mmol) and methyl triphenyl phosphonium bromide (4.37 g, 12.24 mmol) at ambient temperature. Then the resultant reaction mixture was heated at 100° C. for 18 h. After the reaction was deemed complete by TLC, the reaction mixture was cooled to ambient temperature and filtered, and the obtained filtrate was concentrated under reduced pressure. The residue was purified by flash chromatography (SiO2, 100-200 mesh; 20% EtOAc in n-Hexane) to afford the title compound as a white solid (1.94 g, 70%): mp 141-143° C.; 1H NMR (400 MHz, CDCl3) δ 7.85 (m, 2H), 7.70 (m, 2H), 7.41 (m, 1H), 7.21 (m, 2H), 6.71 (dd, J=17.6, 10.8 Hz, 1H), 5.72 (d, J=17.6 Hz, 1H), 5.23 (d, J=10.8 Hz, 1H), 4.92 (s, 2H); ESIMS m/z 298.10 ([M−H]−)
The following compounds were made in accordance with the procedures disclosed in Example 48.
2-(2-(Trifluoromethyl)-4-vinylbenzyl)isoindoline-1,3-dione (CI23)




The title compound was isolated as a light brown solid (0.5 g, 60%): mp 134-135° C.; 1H NMR (400 MHz, CDCl3) δ 7.92 (m, 2H), 7.80 (m, 2H), 7.71 (s, 1H), 7.46 (d, J=8.0 Hz, 1H), 7.16 (d, J=8.0 Hz, 1H), 6.65 (m, 1H), 5.80 (d, J=17.8 Hz, 1H), 5.19 (d, J=10.8 Hz, 1H), 5.09 (s, 2H); ESIMS m/z 332.10 ([M+H]+).
2-(2-Bromo-4-vinylbenzyl)isoindoline-1,3-dione (CI24)




The title compound was isolated as an off white solid (0.5 g, 62%): mp 126-128° C.; 1H NMR (400 MHz, CDCl3) δ 7.92 (m, 2H), 7.79 (m, 2H), 7.62 (s, 1H), 7.21 (m, 1H), 7.16 (d, J=8.0 Hz, 1H), 6.62 (m, 1H), 5.72 (d, J=17.8 Hz, 1H), 5.15 (d, J=10.8 Hz, 1H), 4.95 (s, 2H); EIMS m/z 341.10 ([M]+).
2-(2-Fluoro-4-vinylbenzyl)isoindoline-1,3-dione (CI25)




The title compound was isolated as a white solid (0.5 g, 61%): mp 140-142° C.; 1H NMR (400 MHz, CDCl3) δ 7.85 (m, 2H), 7.72 (m, 2H), 7.25 (m, 1H), 7.11 (m, 2H), 6.63 (m, 1H), 5.80 (d, J=17.6 Hz, 1H), 5.28 (d, J=10.8 Hz, 1H), 4.92 (s, 2H); EIMS m/z 282.08.
Example 49
Preparation of (E)-2-(2-Chloro-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzyl)isoindoline-1,3-dione (CI26)




To a stirred solution of 2-(2-chloro-4-vinylbenzyl)isoindoline-1,3-dione (2.0 g, 6.51 mmol) in 1,2-dichlorobenzene (25 mL) were added 1-(1-bromo-2,2,2-trifluoroethyl)-3,5-dichlorobenzene (3.48 g, 11.36 mmol), CuCl (112 mg, 1.13 mmol) and 2,2-bipyridyl (0.35 g). The resultant reaction mixture was degassed with argon for 30 min and then was stirred at 180° C. for 24 h. After the reaction was deemed complete by TLC, the reaction mixture was cooled to ambient temperature and filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by flash chromatography (SiO2, 100-200 mesh; 25-30% EtOAc in n-hexane) to afford the title compound as solid (1.3 g, 50%): mp 141-143° C.; 1H NMR (400 MHz, CDCl3) δ 7.92 (m, 2H), 7.79 (m, 2H), 7.42 (m, 2H), 7.24 (m, 2H), 7.20 (m, 2H), 6.54 (d, J=16.0 Hz, 1H), 6.34 (dd, J=16.0, 8.0 Hz, 1H), 5.00 (s, 2H), 4.10 (m, 1H); ESIMS m/z 524.07 ([M+H]+).
The following compounds were made in accordance with the procedures disclosed in Example 49.
(E)-2-(2-Chloro-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzyl)isoindoline-1,3-dione (CI27)




The title compound was isolated as a pale white solid (0.2 g, 55%): mp 128-129° C.; 1H NMR (400 MHz, CDCl3) δ 7.92 (m, 2H), 7.79 (m, 2H), 7.42 (m, 3H), 7.22 (m, 2H), 6.52 (d, J=16.0 Hz, 1H), 6.32 (dd, J=16.0, 8.0 Hz, 1H), 5.00 (s, 2H), 4.05 (m, 1H); ESIMS m/z 557.99 ([M+H]+).
(E)-2-(2-Chloro-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzyl)isoindoline-1,3-dione (CI28)




The title compound was isolated as an off white solid (0.2 g, 54%): mp 177-180° C.; 1H NMR (400 MHz, CDCl3) δ 7.90 (m, 2H), 7.77 (m, 2H), 7.42 (s, 1H), 7.32 (d, J=8.0 Hz, 2H), 7.21 (m, 2H), 6.52 (d, J=16.0 Hz, 1H), 6.32 (dd, J=16.0, 8.0 Hz, 1H), 5.00 (s, 2H), 4.05 (m, 1H); ESIMS m/z 540.08 ([M−H]−); IR (thin film) 1716 cm−1.
(E)-2-(2-Chloro-4-(3-(3,4-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzyl)isoindoline-1,3-dione (CI29)




The title compound was isolated as an off-white solid (0.2 g, 59%): 1H NMR (400 MHz, CDCl3) δ 7.89 (m, 2H), 7.76 (m, 2H), 7.47 (m, 3H), 7.21 (m, 3H), 6.50 (d, J=16.0 Hz, 1H), 6.32 (dd, J=16.0, 7.6 Hz, 1H), 4.97 (s, 2H), 4.11 (m, 1H); ESIMS m/z 522.27 ([M−H]−); IR (thin film) 3064, 1717, 1111, 715 cm−1.
(E)-2-(4-(3-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(trifluoromethyl)-benzyl)isoindoline-1,3-dione (CI30)




The title compound was isolated as an off-white solid (0.2 g, 54%): mp 141-142° C.; 1H NMR (400 MHz, CDCl3) 7.94 (m, 2H), 7.80 (m, 2H), 7.69 (s, 1H), 7.44 (m, 1H), 7.38 (m, 1H), 7.24 (m, 2H), 7.19 (m, 1H), 6.60 (d, J=16.0 Hz, 1H), 6.39 (dd, J=16.0, 7.6 Hz, 1H), 5.10 (s, 2H), 4.11 (m, 1H); ESIMS m/z 556.00 ([M−H]−).
(E)-2-(4-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)-2-(trifluoromethyl)-benzyl)isoindoline-1,3-dione (CI31)




The title compound was isolated as an off-white solid (0.2 g, 56%): mp 130-132° C.; 1H NMR (400 MHz, CDCl3) δ 7.94 (m, 2H), 7.80 (m, 2H), 7.69 (s, 1H), 7.44 (m, 3H), 7.19 (m, 1H), 6.61 (d, J=16.0 Hz, 1H), 6.38 (dd, J=16.0, 7.6 Hz, 1H), 5.10 (s, 2H), 4.12 (m, 1H); ESIMS m/z 589.57 ([M−H]−).
(E)-2-(2-Bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzyl)-isoindoline-1,3-dione (CI32)




The title compound was isolated as a pale yellow solid (0.2 g, 55%): mp 160-162° C.; 1H NMR (400 MHz, CDCl3) δ 7.92 (m, 2H), 7.80 (m, 2H), 7.62 (s, 1H), 7.39 (s, 2H), 7.24 (m, 1H), 7.16 (m, 1H), 6.52 (d, J=16.0 Hz, 1H), 6.32 (dd, J=16.0, 8.0 Hz, 1H), 4.98 (s, 2H), 4.12 (m, 1H); ESIMS m/z 599.78 ([M−H]−).
(E)-2-(2-Fluoro-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzyl)-isoindoline-1,3-dione (CI33)




The title compound was isolated as an off-white solid (0.2 g, 55%): mp 72-74° C.; 1H NMR (400 MHz, CDCl3) δ 7.88 (m, 2H), 7.74 (m, 2H), 7.38 (s, 2H), 7.34 (m, 1H), 7.18 (m, 2H), 6.54 (d, J=16.0 Hz, 1H), 6.32 (dd, J=16.0, 8.0 Hz, 1H), 4.91 (s, 2H), 4.08 (m, 1H); ESIMS m/z 539.89 ([M−H]−); IR (thin film) 1773 cm−1.
Prophetically, compounds CI34-CI41 (Table 1) could be made in accordance with the procedures disclosed in Example 49.
Example 50
Preparation of (E)-(2-Chloro-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)phenyl)methanamine (CI42)




To a stirred solution of (E)-2-(2-chloro-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzyl)isoindoline-1,3-dione (0.4 g, 0.76 mmol) in EtOH was added hydrazine hydrate (0.38 g, 7.6 mmol), and the resultant reaction mixture was heated at 80° C. for 2 h. The reaction mixture was filtered, and the filtrate was concentrated. The residue was dissolved in CH2Cl2, washed with brine, dried over Na2SO4, and concentrated under reduced pressure to afford the title compound as a gummy liquid (0.3 g), which was carried on to the next step without further purification.
The following compounds were made in accordance with the procedures disclosed in Example 50.
(E)-(2-Chloro-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)phenyl)-methanamine (CI43)




The product obtained in this reaction was carried on to the next step without further purification.
(E)-(2-Chloro-4-(3-(3,4-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)phenyl)-methanamine (CI44)




The product obtained in this reaction was carried on to the next step without further purification: 1H NMR (400 MHz, CDCl3) δ 7.48 (d, J=8.4 Hz, 2H), 7.39 (m, 2H), 7.23 (m, 2H), 6.52 (d, J=16.0 Hz, 1H), 6.38 (dd, J=16.0, 7.6 Hz, 1H), 4.12 (m, 1H), 3.90 (s, 2H); ESIMS m/z 391.90 ([M−H]−); IR (thin film) 3370, 3280, 1111, 817 cm−1.
(E)-(4-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)-2-(trifluoromethyl)-phenyl)methanamine (CI45)




The title compound was isolated as a gummy material. The product obtained in this reaction was carried on to the next step without further purification.
(E)-(2-Bromo-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)phenyl)-methanamine (CI46)




The title compound was isolated as a gummy material: The product obtained in this reaction was carried on to the next step without further purification.
(E)-(2-Bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)phenyl)-methanamine (CI47)




The title compound was isolated as a gummy material. The product obtained in this reaction was carried on to the next step without further purification.
(E)-(2-Fluoro-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)phenyl)-methanamine (CI48)




The title compound was isolated as a gummy material: 1H NMR (400 MHz, CDCl3) δ 7.40 (s, 2H), 7.33 (t, J=7.6 Hz, 1H), 7.13 (m, 2H), 6.56 (d, J=16.0 Hz, 1H), 6.33 (dd, J=16.0, 7.6 Hz, 1H), 4.08 (m, 1H), 3.90 (s, 2H); ESIMS m/z 413.84 ([M+H]+); IR (thin film) 3368, 3274, 1114, 808 cm−1.
Prophetically, compounds CI49-CI57 (Table 1) could be made in accordance with the procedures disclosed in Example 50.
Example 51
Preparation of 3-Chloro-4-((pyridin-2-ylamino)methyl)benzaldehyde (CI58)




To a stirred solution of 4-(bromomethyl)-3-chlorobenzaldehyde (2 g, 9 mmol) in N,N-dimethylacetamide (DMA; 20 mL) was added K2CO3 (2.36 g, 17.16 mmol) and 2-aminopyridine (0.84 g, 8.58 mmol), and the reaction mixture was stirred at ambient temperature for 4 h. The reaction mixture was diluted with water and extracted with EtOAc. The combined organic layer was washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The residue was purified by flash column chromatography (SiO2, 100-200 mesh; 20% EtOAc in n-Hexane) to afford the title compound as off-white solid (1.05 g, 50%): mp 122-123° C.; 1H NMR (400 MHz, CDCl3) δ 9.94 (s, 1H), 8.11 (s, 1H), 7.88 (s, 1H), 7.72 (d, J=4.8 Hz, 1H), 7.62 (d, J=5.7 Hz, 1H), 7.4 (m, 1H), 6.64 (d, J=3.9 Hz, 1H), 6.38 (d, J=6.3 Hz, 1H), 5.04 (br s, 1H), 4.71 (s, 2H); ESIMS m/z 246.97 ([M+H]+).
Example 52
Preparation of N-(2-Chloro-4-vinylbenzyl)pyridin-2-amine (CI59)




To a stirred solution of 3-chloro-4-((pyridin-2-ylamino)methyl)benzaldehyde (1 g, 4. mmol) in 1,4-dioxane (20 mL) were added K2CO3 (0.84 g, 6.09 mmol) and methyl triphenyl phosphonium bromide (2.17 g, 6.09 mmol) at ambient temperature. Then the resultant reaction mixture was heated at 100° C. for 18 h. After the reaction was deemed complete by TLC, the reaction mixture was cooled to ambient temperature and filtered, and the obtained filtrate was concentrated under reduced pressure. The residue was purified by flash chromatography (SiO2, 100-200 mesh; 10% EtOAc in n-Hexane) to afford the title compound as a white solid (0.5 g, 50%): mp 119-121° C.; 1H NMR (400 MHz, CDCl3) δ 8.12 (s, 1H), 7.42-7.40 (m, 3H), 7.26 (s, 1H), 6.66 (m, 2H), 6.36 (d, J=6.3 Hz, 1H), 5.75 (d, J=13.2 Hz, 1H), 4.92 (br s, 1H), 4.60 (s, 2H); ESIMS m/z 245.05 ([M+H]+).
Example 53
Preparation of Ethyl 2-amino-2-(5-bromo-3-chloropyridin-2-yl)acetate (CI60)




Ethyl 2-(diphenylmethyleneamino)acetate (10.2 g, 38.2 mmol) was added to sodium hydride (NaH; 3.18 g, 133.52 mmol) in DMF (50 mL) at 0° C., and the mixture was stirred for 30 min. To this was added 5-bromo-2,3-dichloropyridine (12.9 g, 57.23 mmol), and the reaction mixture was stirred for 3 h at ambient temperature. The reaction mixture was quenched with 2 N HCl solution and then stirred for 4 h at ambient temperature. The mixture was extracted with EtOAc. The combined EtOAc layer was washed with brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure. Purification by flash column chromatography (20-30% EtOAc in hexane) afforded the title compound as a liquid (1.3 g, 20%): 1H NMR (400 MHz, CDCl3) δ 8.52 (s, 1H), 7.89 (s, 1H), 5.09 (s 1H), 4.23 (m, 2H), 2.27 (br s, 2H), 1.26 (m, 3H); ESIMS m/z 293.05 ([M+H]+); IR (thin film) 3381, 3306, 1742, 759, 523 cm−1.
Example 54
Preparation of (5-Bromo-3-chloropyridin-2-yl)methanamine hydrochloride (CI61)




A stirred solution of ethyl 2-amino-2-(5-bromo-3-chloropyridin-2-yl)acetate (0.5 g, 1.7 mmol) in 3 N HCl (25 mL) was heated at reflux for 4 h. The reaction mixture was washed with Et2O and water. The combined ether layer was concentrated under reduced pressure to afford the title compound as an off-white solid (400 mg, 65%): 1H NMR (400 MHz, CDCl3) δ 8.78 (s, 1H), 8.70 (br s, 2H), 8.45 (s, 1H), 4.56 (m, 2H); ESIMS m/z 221.15 ([M+H]+).
Example 55
Preparation of 2-((5-Bromo-3-chloropyridin-2-yl)methyl)isoindoline-1,3-dione (CI62) 




To a stirred solution of (5-bromo-3-chloropyridin-2-yl)methanamine hydrochloride (0.3 g, 1.4 mmol) in toluene (40 mL) was added TEA (0.41 g, 4.08 mmol) and phthalic anhydride (0.24 g, 1.63 mmol), and the reaction mixture was heated at reflux for 2 h. The reaction mixture was concentrated under reduced pressure, and the residue was diluted with water and extracted with EtOAc. The combined EtOAc layer was washed with brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure. The residue was purified by column chromatography (20-30% EtOAc in hexane) to afford the title compound as a white solid (0.25 g, 65%): 1H NMR (400 MHz, CDCl3) δ 8.78 (s, 1H), 8.45 (s, 1H), 7.88 (m, 2H), 7.74 (m, 2H), 4.56 (m, 2H); ESIMS m/z 349 ([M−H]−); IR (thin film) 3307, 1665, 1114, 813 cm−1.
Example 56
Preparation of 2-((3-Chloro-5-vinylpyridin-2-yl)methyl)isoindoline-1,3-dione (CI63)




To a stirred solution of 2-((5-bromo-3-chloropyridin-2-yl)methyl)isoindoline-1,3-dione (0.23 g, 0.65 mmol) in toluene (10 mL) were added Pd(PPh3)4 (3.7 mg, 0.003 mmol), K2CO3 (0.269 g, 1.95 mmol) and vinyl boronic anhydride pyridine complex (0.78 g, 3.28 mmol), and the reaction mixture was heated at reflux for 16 h. The reaction mixture was filtered, and the filtrate was washed with water and brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure. Purification by flash column chromatography (20-30% EtOAc in hexane) afforded the title compound as an off-white solid (0.2 g, 65%): 1H NMR (400 MHz, CDCl3) δ 8.30 (s, 1H), 7.91 (m, 2H), 7.77 (m, 3H), 7.72 (m, 1H), 6.63 (m, 1H), 5.79 (d, J=16.0 Hz, 1H), 5.39 (d, J=16.0 Hz, 1H), 5.12 (s, 2H); ESIMS m/z 299.20 ([M+H]+).
Example 57
Preparation of (E)-2-((3-Chloro-5-(4,4,4-trifluoro-3-(3,4,5-trichloro-phenyl)but-1-en-1-yl)pyridin-2-yl)methyl)isoindoline-1,3-dione (CI64)




To a stirred solution of 2-((3-chloro-5-vinylpyridin-2-yl)methyl)isoindoline-1,3-dione (0.35 g, 1.17 mmol) in 1,2-dichlorobenzene (10 mL) were added 5-(1-bromo-2,2,2-trifluoroethyl)-1,2,3-trichlorobenzene (0.8 g, 2.3 mmol), CuCl (23 mg, 0.12 mmol), 2,2-bipyridyl (0.073 g, 0.234 mmol), and the reaction mixture was heated at 180° C. for 16 h. The reaction mixture was concentrated under reduced pressure and purified by column chromatography (20-30% EtOAc in hexane) to afford the title compound as a liquid (0.4 g, 50%): mp 79-82° C.; 1H NMR (400 MHz, CDCl3) δ 8.27 (s, 1H), 7.91 (m, 2H), 7.77 (m, 3H), 7.36 (s, 2H), 6.51 (d, J=15.6 Hz, 1H), 6.32 (dd, J=15.6, 8.0 Hz, 1H), 5.30 (s, 2H), 4.13 (m, 1H); ESIMS m/z 559 ([M+H]+).
Example 58
Preparation of (E)-(3-Chloro-5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)pyridin-2-yl)methanamine (CI65)




To a stirred solution of (E)-2-((3-chloro-5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)pyridin-2-yl)methyl)isoindoline-1,3-dione (200 mg, 0.358 mmol) in EtOH (5 mL) was added hydrazine hydrate (89.6 mg, 1.79 mmol), and the reaction mixture was heated at reflux for 2 h. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in CH2Cl2. The organic layer was washed with water and brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure to afford the title compound as a solid (100 mg). The product obtained in this reaction was carried on to the next step without further purification.
Example 59
Preparation of 4-(Bromomethyl)-1-naphthonitrile (CI66) 




To a stirred solution of 4-methyl-1-naphthonitrile (5 g, 30 mmol) in CCl4 (50 mL) under argon atmosphere was added NBS (6.06 g, 34.09 mmol), and the reaction mixture was degassed for 30 min AIBN (0.3 g, 2.1 mmol) was added, and the resultant reaction mixture was heated at reflux for 4 h. The reaction mixture was cooled to ambient temperature, diluted with water and extracted with CH2Cl2 (3×100 mL). The combined CH2Cl2 layer was washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The residue was purified by flash column chromatography (SiO2, 100-200 mesh; 5% EtOAc in n-Hexane) to afford the title compound as a white solid (3.8 g, 52%): mp 131-133° C.; 1H NMR (400 MHz, CDCl3) δ 8.33 (m, 1H), 8.24 (m, 1H), 7.88 (d, J=8.0 Hz, 1H), 7.78 (m, 2H), 7.62 (d, J=8.0 Hz, 1H), 4.95 (s, 2H); ESIMS m/z 245.92 ([M+H]+); IR (thin film) 2217 cm−1.
Example 60
Preparation of 4-(Bromomethyl)-1-naphthaldehyde (CI67)




To a stirred solution of 4-(bromomethyl)-1-naphthonitrile (8 g, 33 mmol) in toluene (100 mL) at 0° C. was added dropwise DIBAL-H (1.0 M solution in toluene; 43 mL), and the reaction mixture was stirred at 0° C. for 1 h. 3 N HCl in water (50 mL) was added to the mixture until it became a white slurry and then additional 1 N HCl (20 mL) was added. The organic layer was collected and the aqueous layer was extracted with EtOAc (3×100 mL). The combined organic layer was dried over Na2SO4 and concentrated under reduced pressure. Purification by flash column chromatography (SiO2, 100-200 mesh; 5% EtOAc in petroleum ether) afforded the title compound as a white solid (7 g, 88%): mp 115-116° C.; 1H NMR (400 MHz, CDCl3) δ 10.41 (s, 1H), 9.35 (m, 1H), 8.22 (m, 1H), 7.90 (d, J=8.0 Hz, 1H), 7.75 (m, 3H), 4.95 (s, 2H); ESIMS m/z 248.88 ([M+H]+).
Example 61
Preparation of 4-((1,3-Dioxoisoindolin-2-yl)methyl)-1-naphthaldehyde (CI68) 




To a stirred solution of 4-(bromomethyl)-1-naphthaldehyde (7 g, 28 mmol) in DMF (100 mL) was added potassium phthalimide (7.3 g, 39.5 mmol), and the mixture was heated at 85° C. for 2 h. The reaction mixture was cooled to ambient temperature and diluted with water (100 mL). The obtained solid was separated by filtration and dried under vacuum to afford the title compound as a white solid (8.8 g, 98%): mp 190-192° C.; 1H NMR (400 MHz, CDCl3) δ 10.39 (s, 1H), 9.25 (m, 1H), 8.41 (m, 1H), 8.10 (d, J=8.0 Hz, 1H), 7.95 (m, 4H), 7.80 (m, 4H), 7.61 (m, 4H), 5.39 (s, 2H); ESIMS m/z 316.09 ([M+H]+); IR (thin film) 1708 cm−1.
Example 62
Preparation of 2-((4-Vinylnaphthalen-1-yl)methyl)isoindoline-1,3-dione (CI69)




To a stirred solution of 4-((1,3-dioxoisoindolin-2-yl)methyl)-1-naphthaldehyde (9 g, 28.5 mmol) in 1,4-dioxane (100 mL) were added K2CO3 (6 g, 42.8 mmol) and methyl triphenyl phosphonium bromide (15.3 g, 35.7 mmol) at ambient temperature. The reaction mixture was heated at 100° C. for 14 h and then was cooled to ambient temperature. The reaction mixture was filtered, and the obtained filtrate was concentrated under reduced pressure. Purification by flash chromatography (SiO2, 100-200 mesh; 20% EtOAc in petroleum ether) afforded the title compound as a white solid (6 g, 67%): mp 146-147° C.; 1H NMR (400 MHz, CDCl3) δ 8.35 (m, 2H), 7.95 (m, 4H), 7.65 (m, 4H), 7.39 (m, 1H), 5.81 (m, 1H), 5.45 (m, 1H), 5.21 (s, 2H); ESIMS m/z 314.13 ([M+H]+).
Example 63
Preparation of (E)-2-((4-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)naphthalen-1-yl)methyl)isoindoline-1,3-dione (CI70) 




To a stirred solution of 2-((4-vinylnaphthalen-1-yl)methyl)isoindoline-1,3-dione (1.5 g, 4.79 mmol) in 1,2-dichlorobenzene (15 mL) were added 1-(1-bromo-2,2,2-trifluoroethyl)-3,4,5-trichlorobenzene (3.2 g, 9.5 mmol), CuCl (24 mg, 0.24 mmol) and 2,2-bipyridyl (0.149 g, 0.95 mmol), and the resultant reaction mixture was degassed with argon for 30 min and then stirred at 180° C. for 14 h. After the reaction was deemed complete by TLC, the reaction mixture was cooled to ambient temperature and filtered, and the filtrate was concentrated under reduced pressure. Purification by flash chromatography (SiO2, 100-200 mesh; 25-30% EtOAc in petroleum ether) afforded the title compound as an off-white solid (1.5 g, 56%): mp 158-160° C.; 1H NMR (400 MHz, CDCl3) δ 8.40 (m, 1H), 7.89 (m, 2H), 7.74 (m, 2H), 7.64 (m, 2H), 7.58 (m, 2H), 7.46 (s, 2H), 7.36 (m, 2H), 6.31 (m, 1H), 5.30 (s, 2H), 4.21 (m, 1H); ESIMS m/z 572.08 ([M−H]−).
Example 64
Preparation of (E)-(4-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)naphthalen-1-yl)methanamine (CI71)




To a stirred solution of (E)-2-((4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)naphthalen-1-yl)methyl)isoindoline-1,3-dione (0.4 g, 0.7 mmol) in EtOH was added hydrazine hydrate (0.18 g, 3.5 mmol), and the resultant reaction mixture was heated at 80° C. for 2 h. The reaction mixture was filtered, and the filtrate was concentrated. The residue was dissolved in CH2Cl2, and the solution was washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The title compound was isolated as a gummy liquid (150 mg, 50%). The product obtained in this reaction was carried on to the next step without further purification.
Example 65
Preparation of 2-((4-Bromophenyl)amino)isoindoline-1,3-dione (CI72) 




To a stirred solution of (4-bromophenyl)hydrazine hydrochloride (0.5 g, 2.2 mmol) in AcOH (8 mL) was added phthalic anhydride (0.398 g, 2.690 mmol), and the reaction mixture was stirred at 130° C. for 1 h under a nitrogen atmosphere. The reaction mixture was quenched with satd aqueous NaHCO3 solution and filtered to give a solid. Purification by column chromatography (SiO2, O-10% EtOAc in petroleum ether) afforded the title compound as a solid (60 mg, 84%): mp 205-206° C.; 1H NMR (400 MHz, CDCl3) δ 8.71 (s, 1H), 7.99 (m, 4H), 7.32 (d, J=8.8 Hz, 2H), 6.79 (d, J=8.8 Hz, 2H); ESIMS m/z 314.95 ([M−H]−).
Example 66
Preparation of 2-((4-Vinylphenyl)amino)isoindoline-1,3-dione (CI73)




To a solution of 2-(4-bromophenylamino)isoindoline-1,3-dione (2 g, 6 mmol) in 1,2-dimethoxyethane (20 mL) and water (4 mL) were added vinyl boronic anhydride pyridine complex (4.57 g, 18.98 mmol) and K2CO3 (1.3 g, 9.5 mmol) followed by Pd(PPh3)4 (0.219 g, 0.189 mmol). The resultant reaction mixture was heated at 150° C. in a microwave for 30 min and then was concentrated under reduced pressure. Purification by column chromatography (SiO2, 15% EtOAc in petroleum ether) afforded the title compound as a solid (200 mg, 13%): mp 174-176° C.; 1H NMR (400 MHz, CDCl3) δ 8.65 (s, 1H), 7.94 (m, 4H), 7.29 (d, J=8.4 Hz, 2H), 6.72 (d, J=8.4 Hz, 2H), 6.61 (m, 1H), 5.61 (d, J=17.6 Hz, 1H), 5.05 (d, J=11.2 Hz, 1H); ESIMS m/z 263.18 ([M−H]−).
Example 67
Preparation of (E)-2-((4-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)phenyl)amino)isoindoline-1,3-dione (CI74)




To a stirred solution of 2-(4-vinylphenylamino)isoindoline-1,3-dione (0.3 g, 1.1 mmol) in 1,2-dichlorobenzene (5 mL) were added CuCl (0.022 g, 0.273 mmol), 2,2-bipyridyl (0.07 g, 0.46 mmol) and 5-(1-bromo-2,2,2-trifluoroethyl)-1,2,3-trichlorobenzene (0.77 g, 2.27 mmol). The reaction mixture was degassed with argon for 30 min and was heated at 180° C. for 2 h. The reaction mixture was then concentrated under reduced pressure, and the residue was purified by column chromatography (SiO2, O-30% EtOAc in petroleum ether) to afford the title compound as a solid (450 mg, 75%): mp 187-189° C.; 1H NMR (400 MHz, CDCl3) δ 8.75 (s, 1H), 7.96 (m, 4H), 7.82 (s, 2H), 7.37 (d, J=8.8 Hz, 1H), 6.73 (d, J=8.4 Hz, 2H), 6.61 (m, 2H), 6.58 (m, 1H), 4.59 (m, 1H); ESIMS m/z 523.05 ([M−H]−).
Example 68
Preparation of (E)-(4-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)phenyl)hydrazine (CI75)




To a stirred solution of (E)-2-(4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)phenylamino) isoindoline-1,3-dione (0.16 g, 0.31 mmol) in EtOH (5 mL), was added hydrazine hydrate (0.076 g, 1.52 mmol), and the reaction mixture was heated at 85° C. for 1 h. The reaction mixture was cooled to ambient temperature and filtered, and the filtrate was concentrated under reduced pressure to afford the title compound as a solid (0.08 g, 66%) which was carried on to the next step without further purification.
Example 69
Preparation of 2-(4-Vinylphenoxy)isoindoline-1,3-dione (CI76)




To a stirred solution of 4-vinylphenylboronic acid (2 g, 13 mmol), 2-hydroxyisoindoline-1,3-dione (3.63 g, 24.53 mmol), and CuCl (1.214 g 12.26 mmol) in 1,2-dichloroethane (50 mL) was added pyridine (1.065 g, 13.48 mmol), and the resultant reaction mixture was stirred at ambient temperature for 48 h. The reaction mixture was diluted with water and extracted with CHCl3. The combined CHCl3 layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure. Purification by flash column chromatography (SiO2; 20% EtOAc in petroleum ether) afforded the title compound as a white solid (2 g, 63%): mp 129-131° C.; 1H NMR (400 MHz, CDCl3) δ 7.93 (d, J=2.0 Hz, 2H), 7.82 (d, J=3.2 Hz, 2H), 7.38 (d, J=2.0 Hz, 2H), 7.14 (d, J=2.0 Hz, 2H), 6.70 (m, 1H), 5.83 (d, J=16.0 Hz, 1H), 5.22 (d, J=10.8 Hz, 1H); ESIMS m/z 266.12 ([M+H]+).
Example 70
Preparation of (E)-2-(4-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)phenoxy)isoindoline-1,3-dione (CI77)




To a stirred solution of 2-(4-vinylphenoxy)isoindoline-1,3-dione (0.3 g, 1.1 mmol) in 1,2-dichlorobenzene (10 mL) was added 1-(1-bromoethyl)-3,4,5-trichlorobenzene (769 mg, 2.26 mmol), CuCl (22 mg, 0.22 mmol) and 2,2-bipyridyl (35 mg, 0.44 mmol), and the resultant reaction mixture was degassed with argon for 30 min and heated to 180° C. for 24 h. The reaction mixture was cooled to ambient temperature and filtered, and the filtrate was concentrated under reduced pressure. The crude material was purified by column chromatography (SiO2, 100-200 mesh; 20% EtOAc in petroleum ether) to afford the title compound as a solid (0.29 g, 50%): 1H NMR (400 MHz, CDCl3) δ 7.90 (m, 1H), 7.62 (m, 2H), 7.50 (m, 1H), 7.40 (s, 2H), 7.12 (s, 1H), 6.90 (m, 2H), 6.60 (m, 2H), 6.20 (m, 1H), 4.08 (m, 1H); ESIMS m/z 524.09 ([M−H]−).
Example 71
Preparation of (E)-O-(4-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)phenyl)hydroxylamine (CI78)




To a stirred solution of (E)-2-(4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)phenoxy)isoindoline-1,3-dione (0.2 g, 0.4 mmol) in EtOH was added hydrazine hydrate (0.1 g, 1.9 mmol), and the resultant reaction mixture was heated at 90° C. for 1 h. The reaction mixture was filtered, and the filtrate was concentrated. The residue was dissolved in CH2Cl2. washed with brine, dried over Na2SO4 and concentrated under reduced pressure to afford the crude title compound as a gummy liquid (0.08 g, 53%): 1H NMR (400 MHz, CDCl3) δ 7.40 (s, 2H), 6.98 (s, 1H), 6.82 (s, 2H), 6.48 (m, 1H), 6.20 (m, 1H), 5.02 (s, 1H), 4.08 (m, 1H); ESIMS m/z 394.94 ([M−H]−).
Example 72
Preparation of (E)-N-(4-(3-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-1-enyl)benzyl)acetamide (CC1)




To a stirred solution of (E)-(2-chloro-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)phenyl)methanamine (0.3 g, 0.8 mmol) in CH2Cl2 (10 mL) was added acetic anhydride (0.12 mL, 1.14 mmol), and TEA (0.217 mL, 1.52 mmol), and the resultant reaction mixture was stirred at ambient temperature for 6 h. The reaction mixture was diluted with water and extracted with CH2Cl2. The combined CH2Cl2 layer was washed with brine, dried over Na2SO4, and concentrated under reduced pressure. Purification by flash column chromatography (SiO2, 100-200 mesh; 30-50% EtOAc in hexane) afforded the title compound as an off-white solid (0.2 g, 60%) mp 107-109° C.; 1H NMR (400 MHz, CDCl3) δ 7.37 (m, 3H), 7.28 (m, 4H), 6.60 (d, J=16.0 Hz, 1H), 6.36 (dd, J=16.0, 8.0 Hz, 1H), 5.75 (br s, 1H), 4.46 (d, J=6 Hz, 2H), 4.01 (m, 1H), 2.11 (s, 3H); ESIMS m/z 402.00 ([M+H]+).
Compounds CC2-CC6 in Table 1 were made in accordance with the procedures disclosed in Example 72. In addition, compound DC56 in Table 1 was made from compound DC55 in accordance with the procedures disclosed in Example 72.
Example 73
Preparation of (E)-N-(2-Chloro-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzyl)acetamide (CC7)




To a stirred solution of (E)-(2-chloro-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)phenyl)methanamine (0.3 g, 0.8 mmol) in DMF (5 mL) was added 2,2,2-trifluoropropanoic acid (97 mg, 0.76 mmol), HOBt.H2O (174 mg, 1.14 mmol) and EDC.HCl (217 mg, 1.14 mmol) and DIPEA (196 mg, 1.52 mmol), and the resultant reaction mixture was stirred at ambient temperature for 18 h. The reaction mixture was diluted with water and extracted with EtOAc. The combined EtOAc layer was washed with brine, dried over Na2SO4, and concentrated under reduced pressure. Purification by flash column chromatography (SiO2, 100-200 mesh; EtOAc in hexane (30-50% afforded the title compound as an off-white solid (0.2 g, 60%): mp 127-128° C.; 1H NMR (400 MHz, CDCl3) δ 7.42 (m, 4H), 7.24 (m, 2H), 6.53 (d, J=16.0 Hz, 1H), 6.36 (dd, J=16.0, 8.0 Hz, 1H), 5.86 (br s, 1H), 4.51 (d, J=6.0 Hz, 2H), 4.05 (m, 1H), 2.02 (s, 3H); ESIMS m/z 436.03 ([M+H]+).
Compounds CC8-CC28 in Table 1 were made in accordance with the procedures disclosed in Example 73.
Example 74
Preparation of (E)-N-(Pyridin-2-ylmethyl)-N-(4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-2-(trifluoromethyl)benzyl)cyclopropanecarboxamide (CC29)




Step 1: (E)-1-(Pyridin-2-yl)-N-(4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-2-(trifluoromethyl)benzyl)methanamine. (E)-(4-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)-2-(trifluoromethyl)phenyl)methanamine (0.46 g, 1 mmol) was dissolved in MeOH (3 mL). To this was added pyridine-2-carbaldehyde (0.107 g, 1 mmol). The reaction mixture was stirred for 1 h. After 1 h, NaBH4 (0.076 g, 2 mmol) was added and left at ambient temperature for 3 h. The reaction mixture was concentrated to give an oily residue. Purification by flash column chromatography (SiO2, 100-200 mesh; 30-50% EtOAc in hexane) afforded the title compound as a pale yellow liquid (0.22 g, 40%): 1H NMR (400 MHz, CDCl3) δ 8.58 (d, J=4.8 Hz, 1H), 7.74 (m, 1H), 7.62 (m, 2H), 7.52 (m, 1H), 7.4 (s, 2H), 7.3 (m, 1H), 7.2 (m, 2H), 6.60 (d, J=16.0 Hz, 1H), 6.38 (dd, J=16.0, 8.0 Hz, 1H), 4.10 (m, 1H), 4.02 (s, 2H), 3.96 (s, 2H); ESIMS m/z 552.95 ([M+H]+); IR (thin film) 3338, 1114, 808 cm−1.
Step 2: (E)-N-(Pyridin-2-ylmethyl)-N-(4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-2-(trifluoromethyl)benzyl)cyclopropanecarboxamide. (E)-1-(Pyridin-2-yl)-N-(4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)-2-(trifluoromethyl)benzyl)methanamine (0.27 g, 0.05 mmol) was taken up in CH2Cl2 (3 mL). To this was added TEA (0.14 mL, 0.1 mmol). The reaction mixture was stirred for 10 min After 10 min, the reaction mixture was cooled to 0° C., and cyclopropylcarbonyl chloride (0.08 mL, 0.075 mmol) was added. The reaction mixture was stirred at ambient temperature for 1 h and then was washed with water and satd aq NaHCO3 solution. The organic layer was dried over anhydrous Na2SO4 and evaporated to obtain pale yellow gummy material (0.15 g, 50%): 1H NMR (400 MHz, CDCl3) δ 8.58 (d, J=4.6 Hz, 1H), 7.74 (m, 1H), 7.62 (m, 2H), 7.52 (m, 1H), 7.4 (s, 2H), 7.3 (m, 1H), 7.2 (m, 2H), 6.60 (d, J=16.0 Hz, 1H), 6.38 (dd, J=16.0, 8.0 Hz, 1H), 5.02 (s, 1H), 4.8 (s, 1H), 4.8 (d, J=10 Hz, 2H), 4.10 (m, 1H), 1.8 (m, 1H), 1.2 (m, 2H), 0.6 (m, 2H); ESIMS m/z 620.86 ([M−H]−); IR (thin film) 1645, 1115, 808 cm−1.
Example 75
Preparation of (E)-N-(2-Chloro-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzyl)-3-(methylsulfonyl)propanamide (CC30)




(E)-N-(2-Chloro-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzyl)-3-(methylthio)propanamide (0.15 g, 0.28 mmol) was treated with oxone (0.175 g, 0.569 mmol) in 1:1 acetone:water (20 mL) for 4 h at ambient temperature. The acetone was evaporated to obtain a white solid (0.095 g, 60%): mp 101-104° C.; 1H NMR (400 MHz, CDCl3) δ 7.41 (m, 4H), 7.24 (m, 1H), 6.53 (d, J=16.0 Hz, 1H), 6.35 (dd, J=16.0, 8.0 Hz, 1H), 6.12 (br s, 1H), 4.53 (m, 2H), 4.10 (m, 1H), 3.42 (m, 2H), 2.91 (s, 3H), 2.78 (m, 2H); ESIMS m/z 559.75 ([M−H]−).
Example 76
Preparation of (E)-1-(2-Chloro-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzyl)-3-ethylurea (CC31)




To a stirred solution of (E)-(2-chloro-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)phenyl)methanamine (0.2 g, 0.5 mmol) in CH2Cl2 (5 mL) at 0° C. were added TEA (0.141 mL, 1 mmol) and ethylisocyanate (0.053 g, 0.75 mmol), and the reaction mixture was stirred for 1 h at 0° C. The reaction mixture was diluted with CH2Cl2. The organic layer was washed with water and brine, dried over Na2SO4, and concentrated under reduced pressure. Purification by column chromatography (SiO2, 100-200 mesh; 30-50% EtOAc in hexane) afforded the title compound as a solid (0.141 g, 60%): mp 177-178° C.; 1H NMR (400 MHz, CDCl3) δ 7.58 (m, 2H), 7.41 (m, 3H), 7.24 (m, 1H), 6.53 (d, J=16.0 Hz, 1H), 6.35 (dd, J=16.0, 8.0 Hz, 1H), 4.70 (br s, 1H), 4.43 (s, 2H), 4.08 (m, 1H), 3.21 (m, 2H), 1.25 (m, 3H); ESIMS m/z 463 ([M−H]−).
Compounds CC32-CC35 in Table 1 were made in accordance with the procedures disclosed in Example 76.
Example 77
Preparation of (E)-3-(2-Chloro-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzyl)-1,1-dimethylurea (CC36)




To a stirred solution of (E)-(2-chloro-4-(3-(3,4,5-trichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)phenyl)methanamine (0.2 g, 0.5 mmol) in CH2Cl2 (5 mL) at 0° C. were added TEA (0.141 mL, 1 mmol) and N,N-dimethylcarbamoyl chloride (0.08 g, 0.075 mmol), and the reaction mixture was stirred for 1 h at 0° C. The reaction mixture was diluted with CH2Cl2. The organic layer was washed with water and brine, dried over Na2SO4, and concentrated under reduced pressure. Purification by column chromatography (SiO2, 100-200 mesh; 30-50% EtOAc in hexane) afforded the title compound as a solid (0.15 g, 60%): 1H NMR (400 MHz, CDCl3) δ 7.39 (m, 4H), 7.28 (m, 1H), 6.54 (d, J=16.0 Hz, 1H), 6.34 (dd, J=16.0, 8.0 Hz, 1H), 4.97 (br s, 1H), 4.38 (d, J=6.0 Hz, 2H), 4.10 (m, 1H), 2.9 (s, 3H), 2.7 (s, 3H); ESIMS m/z 497 ([M−H]−); IR (thin film) 3350, 1705, 1114, 808 cm−1.
Example 78
Preparation of (E)-1-(2-Chloro-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzyl)-3-ethylthiourea (CC37)




To a stirred solution of (E)-(2-chloro-4-(3-(3,4,5-trichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)phenyl)methanamine (0.2 g, 0.5 mmol) in CH2Cl2 (5 mL) at 0° C. were added TEA (0.141 mL, 1 mmol) and ethyl isothicyanate (0.053 g, 0.75 mmol), and the reaction mixture was stirred for 1 h at 0° C. The reaction mixture was diluted with CH2Cl2. The organic layer was washed with water and brine, dried over Na2SO4, and concentrated under reduced pressure. Purification by column chromatography (SiO2, 100-200 mesh; 30-50% EtOAc in hexane) afforded the title compound as a solid (0.14 g, 60%): mp 88-91° C.; 1H NMR (400 MHz, CDCl3) δ 7.49 (d, J=8 Hz, 1H), 7.41 (d, J=7.2 Hz, 2H), 7.26 (m, 2H), 6.50 (d, J=16 Hz, 1H), 6.35 (dd, J=16.0, 8.0 Hz, 1H), 6.0 (br s, 1H), 5.73 (br s, 1H), 4.80 (br s, 2H), 4.09 (m, 1H), 1.23 (m, 3H); ESIMS m/z 515.01 ([M+H]+).
Compound CC38 in Table 1 was made in accordance with the procedures disclosed in Example 78.
Example 79
Preparation of (E)-tert-Butyl (2-chloro-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzyl)-3-ethylurea (CC39)




To a stirred solution of (E)-(2-chloro-4-(3-(3,4,5-trichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)phenyl)methanamine (0.2 g, 0.5 mmol in CH2Cl2 (5 mL) at 0° C. were added TEA (0.141 mL, 1 mmol) and di-tert-butyl dicarbonate (0.163 mL, 0.75 mmol), and the reaction mixture was stirred for 4 h at ambient temperature. The reaction mixture was diluted with CH2Cl2. The organic layer was washed with water and brine, dried over Na2SO4, and concentrated under reduced pressure. Purification by column chromatography (SiO2, 100-200 mesh; 10-20% EtOAc in hexane) afforded the title compound as a white solid (0.147 g, 60%): 1H NMR (400 MHz, CDCl3) δ 7.39 (m, 4H), 7.28 (m, 1H), 6.54 (d, J=16.0 Hz, 1H), 6.34 (dd, J=16.0, 8.0 Hz, 1H), 4.97 (br s, 1H), 4.38 (d, J=6.0 Hz, 2H), 4.10 (m, 1H), 1.53 (s, 9H); ESIMS m/z 526.09 ([M−H]−); IR (thin film) 3350, 1705, 1114, 808 cm−1.
Compound CC40 in Table 1 was made in accordance with the procedures disclosed in Example 79.
Example 80
Preparation of (E)-Methyl 2-((2-chloro-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzyl)amino)-2-oxoacetate (CC41)




To a stirred solution of (E)-(2-chloro-4-(3-(3,4,5-trichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)phenyl)methanamine (0.2 g, 0.5 mmol) in CH2Cl2 (5 mL) at 0° C. were added TEA (0.141 mL, 1 mmol) and methyl 2-chloro-2-oxoacetate (0.09 g, 0.75 mmol), and the reaction mixture was stirred for 1 h at 0° C. The reaction mixture was diluted with CH2Cl2. The organic layer was washed with water and brine, dried over Na2SO4, and concentrated under reduced pressure. Purification by column chromatography (SiO2, 100-200 mesh; 20% EtOAc in hexane) afforded the title compound as a solid (0.12 g, 50%): 1H NMR (400 MHz, CDCl3) δ 7.48 (m, 1H). 7.43 (m, 3H), 7.38 (m, 1H), 7.23 (s, 1H), 6.55 (d, J=16.0 Hz, 1H), 6.36 (dd, J=16.0, 8.0 Hz, 1H), 4.60 (d, J=4.4 Hz, 2H), 4.18 (m, 1H), 3.85 (s, 3H); ESIMS m/z 512.22 ([M−H]−); IR (thin film) 1740, 1701, 1114, 808 cm−1.
Example 81
Preparation of (E)-N1-(2-Chloro-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzyl)-N2-(2,2,2-trifluoroethyl)oxalamide (CC42)




To a stirred solution of 2,2,2-trifluoroethylamine hydrochloride (0.1 g, 0.77 mmol) in CH2Cl2 (10 mL) was added dropwise trimethylaluminum (2 M solution in toluene; 0.39 mL, 0.77 mmol), and the reaction mixture was stirred at 25° C. for 30 min A solution of (E)-methyl 2-((2-chloro-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)-benzyl)-2-oxoacetate (0.2 g, 0.38 mmol) in CH2Cl2 (5 mL) was added dropwise to the reaction mixture at 25° C. The reaction mixture was stirred at reflux for 18 h, cooled to 25° C., quenched with 0.5 N HCl solution (50 mL) and extracted with EtOAc (2×50 mL). The combined organic extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The crude compound was purified by flash chromatography (SiO2, 100-200 mesh; 20%-40% EtOAc in n-hexane) to afford the title compound (0.13 g, 60%): mp 161-163° C.; 1H NMR (400 MHz, DMSO-d6) δ 9.45 (br s, 2H), 7.90 (s, 2H), 7.75 (s, 1H), 7.46 (s, 1H), 7.28 (s, 1H), 6.93 (m, 1H), 6.75 (m, 1H), 4.80 (m, 1H), 4.40 (s, 2H), 3.90 (s, 2H); ESIMS m/z 578.96 ([M−H]−).
Example 82
Preparation of (E)-N-(2-Chloro-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzyl)pyridin-2-amine (CC43)




To a stirred solution of N-(2-chloro-4-vinylbenzyl)pyridin-2-amine (0.3 g, 1.22 mmol) in 1,2-dichlorobenzene (5 mL) were added 5-(1-bromo-2,2,2-trifluoroethyl)-1,2,3-trichlorobenzene (0.83 g, 2.44 mmol), CuCl (24 mg, 0.24 mmol) and 2,2-bipyridyl (76 mg, 0.48 mmol). The resultant reaction mixture was degassed with argon for 30 min and then stirred at 180° C. for 24 h. After the reaction was deemed complete by TLC, the reaction mixture was cooled to ambient temperature and filtered, and the filtrate was concentrated under reduced pressure. Purification by flash chromatography (SiO2, 100-200 mesh; 15% EtOAc in n-hexane) afforded the title compound as an off-white solid (0.2 g, 35%): mp 140-142° C.; 1H NMR (400 MHz, CDCl3) δ 8.11 (d, J=4.0 Hz, 1H), 7.40 (m, 5H), 7.22 (m, 1H), 6.61 (m, 2H), 6.35 (m, 2H), 4.94 (br s, 1H), 4.61 (d, J=6.4 Hz, 2H), 4.11 (m, 1H); ESIMS m/z 505.39 ([M+H]+).
Example 83
Preparation of (E)-N-((3-Chloro-5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)-but-1-en-1-yl)pyridin-2-yl)methyl)-3,3,3-trifluoropropanamide (CC44)




To a stirred solution of (E)-(3-chloro-5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)pyridin-2-yl)methanamine (0.1 g, 0.2 mmol) in CH2Cl2 (5 mL) were added 3,3,3-trifluoropropanoic acid (45 mg, 0.350 mmol), EDC.HCl (67 mg, 0.350 mmol), HOBt.H2O (71 mg, 0.467 mmol) and DIPEA (60.2 mg, 0.467 mmol), and the reaction mixture was stirred at ambient temperature for 18 h. The reaction mixture was diluted with CH2Cl2 and washed with water. The combined CH2Cl2 layer was washed with brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure. Purification by flash column chromatography (SiO2, 100-200 mesh; 15% EtOAc in petroleum ether) afforded the title compound as a pale yellow liquid (30 mg, 35%): 1H NMR (400 MHz, CDCl3) δ 8.41 (s, 1H), 7.77 (s, 1H), 7.47 (br s, 1H), 7.40 (s, 2H), 6.58 (d, J=16.0 Hz, 1H), 6.45 (dd, J=16.0, 8.0 Hz, 1H), 4.68 (d, J=4.0 Hz, 2H), 4.14 (m, 1H), 3.24 (q, J=10.8 Hz, 2H); ESIMS m/z 536.88 ([M−H]−); IR (thin film) 3320, 1674, 1114, 808.
Compound CC45 in Table 1 was made in accordance with the procedures disclosed in Example 83.
Example 84
Preparation of (E)-3,3,3-Trifluoro-N-((4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)naphthalen-1-yl)methyl)propanamide (CC46)




To a stirred solution of (E)-(4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)naphthalen-1-yl)methanamine (0.1 g, 0.22 mmol) in CH2Cl2 (8 mL) were added 3,3,3-trifluoropropanoic acid (0.032 g, 0.24 mmol), HOBt.H2O (52 mg, 0.33 mmol), EDC.HCl (0.065 g, 0.33 mmol) and DIPEA (0.044 g, 0.45 mmol), and the resultant reaction mixture was stirred at ambient temperature for 18 h. The reaction mixture was diluted with water and extracted with EtOAc (3×30 mL). The combined EtOAc layer was washed with brine, dried over Na2SO4, and concentrated under reduced pressure. Purification by flash column chromatography (SiO2, 100-200 mesh; 15% EtOAc in n-hexane) afforded the title compound as a gummy material (60 mg, 50%): mp 151-153° C.; 1H NMR (400 MHz, CDCl3) δ 8.06 (m, 1H), 7.61 (m, 4H), 7.48 (s, 2H), 7.44 (d, J=8.0 Hz, 1H), 7.38 (m, 1H), 6.42 (m, 1H), 5.92 (br s, 1H), 4.92 (m, 2H), 4.24 (m, 1H), 3.12 (m, 2H); ESIMS m/z 554.04 ([M−H]−).
Compounds CC47-CC48 in Table 1 were made in accordance with the procedures disclosed in Example 84.
Example 85
Preparation of (E)-1-Ethyl-3-((4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)naphthalen-1-yl)methyl)urea (CC49)




To a stirred solution of (E)-(4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)naphthalen-1-yl)methanamine (0.1 g, 0.22 mmol) in CH2Cl2 at 0° C. were added TEA (0.064 mL, 0.44 mmol) and ethylisocyanate (0.023 mL, 0.33 mmol), and the reaction mixture was stirred for 1 h at 0° C. The reaction mixture was diluted with CH2Cl2. The organic layer was washed with water and brine, dried over Na2SO4, and concentrated under reduced pressure. Purification by column chromatography (SiO2, 100-200 mesh; 30% EtOAc in hexane) afforded the title compound as a solid (0.07 g, 60%): mp 84-87° C.; 1H NMR (400 MHz, CDCl3) δ 8.06 (m, 1H), 7.98 (m, 1H), 7.61 (m, 3H), 7.48 (s, 2H), 7.44 (d, J=8.0 Hz, 1H), 7.38 (m, 2H), 6.42 (m, 1H), 4.92 (s, 2H), 4.6 (br s, 1H), 4.24 (m, 1H), 3.21 (m, 2H), 1.2 (t, J=4.6 Hz, 3H); ESIMS m/z 515.33 ([M+H]+).
Example 86
Preparation of (E)-N′-(4-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)phenyl)cyclopropanecarbohydrazide (CC50)




To a stirred solution of (E)-(4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)phenyl)hydrazine (0.1 g, 0.3 mmol) in CH2Cl2 (10 mL) was added DIPEA (65 mg, 0.51 mmol), HOBt.H2O (59 mg, 0.38 mmol), EDC.HCl (73 mg, 0.38 mmol) and cyclopropanecarbonyl chloride (0.024 g, 0.28 mmol), and the reaction mixture was stirred at ambient temperature for 1 h. The reaction mixture was diluted with satd aq NaHCO3 solution and extracted with CH2Cl2. The combined CH2Cl2 layer was washed with brine, dried over anhydrous Na2SO4, and concentrated under reduced pressure. Purification by flash column chromatography (SiO2; 5-25% EtOAc in petroleum ether) afforded the title compound as a solid (65 mg, 55%): mp 138-140° C.; 1H NMR (400 MHz, CDCl3) δ 9.81 (s, 1H), 7.90 (s, 1H), 7.84 (s, 2H), 7.34 (d, J=8.4 Hz, 2H), 6.65 (d, J=15.6 Hz, 1H), 6.61 (m, 1H), 6.57 (s, 1H), 6.48 (dd, J=15.6, 8.8 Hz, 1H), 4.74 (m, 1H), 1.64 (m, 1H), 0.75 (m, 4H); ESIMS m/z 461.32 ([M−H]−).
Compound CC51 in Table 1 was made in accordance with the procedures disclosed in Example 86.
Example 87
Preparation of (E)-N-(4-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)phenoxy)cyclopropanecarboxamide (CC52)




To a stirred solution of (E)-O-(4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)phenyl)hydroxylamine (0.15 g, 0.38 mmol) in CH2Cl2 (5 mL) was added EDC.HCl (0.109 g, 0.569 mmol), HOBt.H2O (0.087 g, 0.569 mmol), DIPEA (0.097 g, 0.758 mmol) and cyclopropanecarboxylic acid (0.049 g, 0.569 mmol). The resultant reaction mixture was stirred at ambient temperature for 18 h. The reaction mixture was diluted with water and extracted with CHCl3 (35 mL) The combined CHCl3 layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure. Purification by flash column chromatography (SiO2; 20% EtOAc in hexane) afforded the title compound as a brown liquid (0.06 g, 34%): 1H NMR (400 MHz, CDCl3) δ 7.40 (s, 2H), 7.18 (s, 1H), 7.08 (s, 1H), 6.85 (m, 1H), 6.45 (m, 1H), 6.65 (m, 1H), 6.20 (m, 1H), 5.55 (s, 1H), 4.08 (m, 1H), 1.90 (m, 1H), 1.30-1.10 (m, 4H); ESIMS m/z 464.87 ([M−H]−).
Compound CC53 in Table 1 was made in accordance with the procedures disclosed in Example 87.
Example 88
Preparation of (Z)-3,3,3-Trifluoro-N-(4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzyl)propanamide (CC54) 




A silicon borate vial was charged with (E)-3,3,3-trifluoro-N-(4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzyl)propanamide (133 mg, 0.269 mmol) and dimethyl sulfoxide (DMSO; 10 mL). The mixture was placed within 0.6 to 1 meter (m) of a bank of eight 115 watt Sylvania FR48T12/350BL/VHO/180 Fluorescent Tube Black Lights and four 115 watt Sylvania (daylight) F48T12/D/VHO Straight T12 Fluorescent Tube Lights for 72 h. The mixture was concentrated in vacuo and purified by reverse phase chromatography to give the title compound as a colorless oil (11 mg, 8%): 1H NMR (300 MHz, CDCl3) δ 7.28 (s, 2H), 7.25 (m, 2H), 7.10 (d, J=8.0 Hz, 2H), 6.89 (d, J=11.4 Hz, 1H), 6.07 (br s, 1H), 6.01 (m, 1H), 4.51 (d, J=5.8 Hz, 2H), 4.34 (m, 1H), 3.12 (q, J=7.5 Hz, 2H); 13C NMR (101 MHz, CDCl3) δ 162.44, 137.20, 135.38, 135.23, 134.82, 134.68, 131.71, 129.00, 128.80, 128.69, 128.10, 127.96, 122.63, 76.70, 47.33 (q, J=28 Hz), 43.59, 42.12 (q, J=30 Hz); ESIMS m/z 504 ([M+H]+).
Compounds DC46, AC93. AC94 in Table 1 were made in accordance with the procedures disclosed in Example 88.
Example 89
Preparation of 1-(1-Bromo-2,2,2-trifluoroethyl)-3-chlorobenzene (DI2)




The title compound was synthesized in two steps via 1-(3-chlorophenyl)-2,2,2-trifluoroethanol (DI1, prepared as in Step 1, Method B in Example 1); isolated as a colorless viscous oil (1.5 g, 75%): 1H NMR (400 MHz, CDCl3) δ 7.50 (s, 1H), 7.42-7.35 (m, 3H), 5.02 (m, 1H), 2.65 (br s, 1H)) and Step 2 in Example 1 and isolated (0.14 g, 22%): 1H NMR (400 MHz, CDCl3) δ 7.50 (br s, 1H), 7.42-7.35 (m, 3H), 5.07 (m, 1H).
The following compounds were made in accordance with the procedures disclosed in Example 89.
(1-Bromo-2,2,2-trifluoroethyl)benzene (DI4) 




2,2,2-Trifluoro-1-phenylethanol (DI3) was isolated (10 g, 80%): 1H NMR (300 MHz, CDCl3) δ 7.48 (m, 2H), 7.40 (m, 3H), 5.02 (m, 1H), 2.65 (d, J=7.1 Hz, 1H). The title compound (DI4) was isolated as a liquid (8.0 g, 60%): 1H NMR (400 MHz, CDCl3) δ 7.50 (m, 2H), 7.40 (m, 3H), 5.00 (q, J=7.5 Hz, 1H).
1-(1-Bromo-2,2,2-trifluoroethyl)-3,5-dimethylbenzene (DI20)




1-(3,5-Dimethylphenyl)-2,2,2-trifluoroethanol (DI19) was isolated an off white solid: 1H NMR (400 MHz, CDCl3) δ 7.05 (s, 2H), 7.02 (s, 1H), 4.95 (m, 1H), 2.32 (s, 6H); ESIMS m/z 204 (ND. The title compound (DI20) was isolated (3.0 g, 51%).
1-(1-Bromo-2,2,2-trifluoroethyl)-2,4-dichlorobenzene (DI22)




1-(2,4-Dichlorophenyl)-2,2,2-trifluoroethanol (DI21) was isolated as an off white powder (5.3 g, 61%): mp 49-51° C.; 1H NMR (400 MHz, CDCl3) δ 7.62-7.66 (d, 1H), 7.42-7.44 (d, 1H), 7.32-7.36 (d, 1H), 5.6 (m, 1H), 2.7 (s, 1H); ESIMS m/z 244 ([M]+). The title compound (DI22) was isolated (3.2 g, 50%): 1H NMR (400 MHz, CDCl3) δ 7.62-7.72 (m, 1H), 7.4-7.42 (m, 1H), 7.3-7.38 (m, 1H), 5.7-5.8 (m, 1H).
1-(1-Bromo-2,2,2-trifluoroethyl)-2,3-dichlorobenzene (DI24)




1-(2,3-Dichlorophenyl)-2,2,2-trifluoroethanol (DI23) was isolated as a pale yellow oil (5.2 g, 60%): 1H NMR (400 MHz, CDCl3) δ 7.62-7.64 (d, 1H), 7.52-7.54 (m, 1H), 7.29-7.33 (t, 1H), 5.6-5.76 (m, 1H), 2.7 (s, 1H); ESIMS m/z 243.9 ([M]+). The title compound (DI24) was isolated as an oil (8.7 g, 60%): 1H NMR (400 MHz, CDCl3) δ 7.62-7.71 (m, 1H), 7.44-7.52 (m, 1H), 7.27-7.3 (s, 1H), 5.81-5.91 (m, 1H).
2-(1-Bromo-2,2,2-trifluoroethyl)-1,4-dichlorobenzene (DI26)




1-(2,5-Dichlorophenyl)-2,2,2-trifluoroethanol (DI25) was isolated as a yellow oil (4.1 g, 60%): 1H NMR (400 MHz, CDCl3) δ 7.68-7.7 (s, 1H), 7.3-7.37 (m, 2H), 5.51-5.6 (m, 1H), 2.7 (s, 1H); ESIMS m/z 244 ([M]+)). The title compound (DI26) was isolated (3.0 g, 60%): 1H NMR (400 MHz, CDCl3) δ 7.7-7.78 (m, 1H), 7.3-7.4 (m, 2H), 5.7-5.8 (m, 1H).
1-(1-Bromo-2,2,2-trifluoroethyl)-3,5-bis(trifluoromethyl)benzene (DI28)




1-(3,5-Bis(trifluoromethyl)phenyl)-2,2,2-trifluoroethanol (DI27) was isolated (3.8 g, 60%): 1H NMR (400 MHz, CDCl3) δ 7.98 (m, 3H), 5.25 (m, 1H), 3.2 (br, 1H); ESIMS m/z 312.2 ([M]+). The title compound (DI28) was prepared and carried on crude.
1-(1-Bromo-2,2,2-trifluoroethyl)-2,3,5-trichlorobenzene (DI30)




2,2,2-Trifluoro-1-(2,3,5-trichlorophenyl)ethanol (DI29) was isolated as a white solid (4.0 g, 60%): mp 113-115° C.; 1H NMR (400 MHz, CDCl3) δ 7.62 (d, 1H), 7.50 (d, 1H), 5.60-5.70 (m, 1H), 2.75 (s, 1H); ESIMS m/z 278.0 ([M]+). The title compound (DI30) was isolated (2.9 g, 60%): 1H NMR (400 MHz, CDCl3) δ 7.70 (d, 1H), 7.50 (d, 1H), 5.72-5.82 (m, 1H).
1-(1-Bromo-2,2,2-trifluoroethyl)-3-chloro-5-(trifluoromethyl)benzene (DI32)




1-(3-Chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethanol (DI31) was isolated as a pale yellow oil (2.0 g, 50%): 1H NMR (400 MHz, CDCl3) δ 7.51 (m, 3H), 5.08 (m, 1H), 2.81 (s, 1H); ESIMS m/z 278.1 ([M]+). The title compound (DI32) was isolated oil (2.0 g, 40%): ESIMS m/z 342 ([M]+).
5-(1-Bromo-2,2,2-trifluoroethyl)-1,3-dichloro-2-methoxybenzene (DI34)




1-(3,5-Dichloro-4-methoxyphenyl)-2,2,2-trifluoroethanol (DI33) was isolated as an off white solid (0.8 g, 60%); mp 92-95° C.: 1H NMR (400 MHz, CDCl3) δ 7.41 (s, 2H), 5.00 (m, 1H), 3.89 (s, 3H), 2.64 (m, 1H); ESIMS m/z 274 ([M]+). The title compound (DI34) was isolated as a colorless liquid (0.6 g, 57%).
Example 90
Preparation of 1-(1-Bromo-2,2,2-trifluoroethyl)-3,5-difluorobenzene (DI36)




The title compound was synthesized in two steps via 1-(3,5-difluorophenyl)-2,2,2-trifluoroethanol (DI35, prepared as in Step 1, Method A in Example 1; isolated as a colorless oil (0.2 g, 75%): 1H NMR (400 MHz, CDCl3) δ 7.05 (m, 2H), 6.88 (m, 1H), 5.06 (m, 1H), 2.66 (s, 1H); ESIMS m/z 212 ([M]+) and Step 2 in Example 1 and isolated (3.2 g, 50%); 1H NMR (400 MHz, CDCl3) δ 7.05 (m, 2H), 6.86 (m, 1H), 5.03 (q, J=7.4 Hz, 1H).
The following compounds were made in accordance with the procedures disclosed in Example 90.
1-(1-Bromo-2,2,2-trifluoroethyl)-4-chlorobenzene (DI38) 




1-(4-Chlorophenyl)-2,2,2-trifluoroethanol (DI37) was isolated as a colorless oil (5.0 g, 99%): 1H NMR (400 MHz, CDCl3) δ 7.44-7.38 (m, 4H), 5.05 (m, 1H), 2.55 (s, 1H); ESIMS m/z 210 ([M]+). The title compound (DI38) was isolated (3.0 g, 46%): 1H NMR (400 MHz, CDCl3) δ 7.45 (d, J=8.2 Hz, 2H), 7.37 (d, J=8.2 Hz, 2H), 5.10 (q, J=7.2 Hz, 1H).
1-(1-Bromo-2,2,2-trifluoroethyl)-4-methoxybenzene (DI40)




2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanol (DI39) was isolated as a pale yellow liquid: 1H NMR (400 MHz, CDCl3) δ 7.41 (d, J=8.8 Hz, 2H), 6.95 (m, J=8.8 Hz, 2H), 5.00 (m, 1H), 3.82 (s, 3H), 2.44 (s, 1H); ESIMS m/z 206.1 ([M]+). The title compound (DI40) was isolated (3.8 g, 62%).
1-(1-Bromo-2,2,2-trifluoroethyl)-4-fluorobenzene (DI42)




2,2,2-Trifluoro-1-(4-fluorophenyl)ethanol (DI41) was isolated as a colorless oil (5 g, 99%): 1H NMR (400 MHz, CDCl3) δ 7.48-7.45 (m, 2H), 7.13-7.07 (m, 2H), 5.06 (m, 1H), 2.53 (s, 1H); ESIMS m/z 194 ([M]+). The title compound (DI42) was prepared and carried on as crude intermediate.
1-(1-Bromo-2,2,2-trifluoroethyl)-4-methylbenzene (DI44)




2,2,2-Trifluoro-1-(p-tolyl)ethanol (DI43) was isolated as colorless oil (5.0 g, 99%): 1H NMR (400 MHz, CDCl3) δ 7.37 (d, J=8.0 Hz, 2H), 7.23 (d, J=8.0 Hz, 2H), 5.02 (m, 1H), 2.46 (m, 1H), 2.37 (s, 3H); ESIMS m/z 190 ([M]+). The title compound (DI44) was isolated (3.0 g, 45%).
1-(1-Bromo-2,2,2-trifluoroethyl)-3-fluorobenzene (DI46)




2,2,2-Trifluoro-1-(3-fluorophenyl)ethanol (DI45) was isolated as a colorless viscous oil (2.8 g, 93%): 1H NMR (400 MHz, CDCl3) δ 7.41 (m, 1H), 7.25 (m, 2H), 7.14 (m, 1H), 5.06 (m, 1H), 2.60 (s, 1H); ESIMS m/z 194 ([M]+). The title compound (DI46) was isolated (2.0 g, 61%).
1-(1-Bromo-2,2,2-trifluoroethyl)-2-fluorobenzene (DI48)




2,2,2-Trifluoro-1-(2-fluorophenyl)ethanol (DI47) was isolated as a colorless oil (2.5 g, 99%): 1H NMR (400 MHz, CDCl3) δ 7.40 (m, 1H), 7.43 (m, 1H), 7.24 (m, 1H), 7.13 (m, 1H), 5.42 (m, 1H), 2.65 (s, 1H); ESIMS m/z 194 ([M]+). The title compound (DI48) was isolated (2.0 g, 61%): 1H NMR (400 MHz, CDCl3) δ 7.61 (m, 1H), 7.40 (m, 1H), 7.23 (m, 1H), 7.10 (m, 1H), 5.40 (m, 1H); GCMS m/z 255 ([M−H]−).
Example 91
Preparation of 4-(1H-1,2,4-triazol-1-yl)benzaldehyde (DI5)




To a stiffing solution of 4-fluorobenzaldehyde (10.0 g, 80.6 mmol) in DMF (150 mL) were added K2CO3 (13.3 g, 96.7 mmol) and 1,2,4-triazole (6.67 g, 96.7 mmol) and the resultant reaction mixture was stirred at 120° C. for 6 h. After completion of reaction (by TLC), the reaction mixture was diluted with water and extracted with EtOAc (3×100 mL). The combined EtOAc layer was washed with water and brine, dried over Na2SO4, and concentrated under reduced pressure to afford the title compound as a solid (9.0 g, 65%): mp 145-149° C.: 1H NMR (400 MHz, CDCl3) δ 10.08 (s, 1H), 8.70 (s, 1H), 8.16 (s, 1H), 8.06 (d, J=8.0 Hz, 2H), 7.92 (d, J=8.0 Hz, 2H); ESIMS m/z 173.9 ([M+H]+).
The following compound was made in accordance with the procedures disclosed in Example 91.
5-Formyl-2-(1H-1,2,4-triazol-1-yl)benzonitrile (DI49)




The title compound was isolated (2.8 g, 60%); 1H NMR (400 MHz, CDCl3) δ 10.10 (s, 1H), 8.98 (s, 1H), 8.35 (s, 1H), 8.30 (d, 1H), 8.22 (s, 1H), 8.07 (d, 1H); IR (thin film) 3433, 3120, 1702, 1599, 1510 cm−1.
2-Chloro-4-(1H-1,2,4-triazol-1-yl)benzaldehyde (DI50)




The title compound was isolated as an off white solid (3.0 g, 40%): mp 149-151° C.; 1H NMR (400 MHz, CDCl3) δ 10.05 (s, 1H), 8.74 (s, 1H), 8.17 (s, 1H), 8.10 (s, 1H), 7.90 (m, 2H); ESIMS m/z 208.10 ([M+H]+).
5-Methyl-4-(1H-1,2,4-triazol-1-yl)benzaldehyde (DI51)




The title compound was isolated as a white solid (0.5 g, 74%): mp 109-111° C.; 1H NMR (400 MHz, D6-DMSO) δ 10.06 (s, 1H), 9.00 (s, 1H), 8.30 (s, 1H), 7.99 (s, 1H), 7.92 (d, J=9.2 Hz, 1H), 7.69 (d, J=9.2 Hz, 1H), 2.30 (s, 3H); ESIMS m/z 188.13 ([M+H]+).
Example 92
Preparation of 5-Formyl-2-(3-nitro-1H-1,2,4-triazol-1-yl)benzonitrile (DI52) 




To a stirring solution of 2-fluoro-5-formylbenzonitrile (0.5 g, 3.3 mmol) in DMF (25 mL) were added K2CO3 (0.68 g, 4.95 mmol) and 3-nitro-1,2,4 triazole (0.45 g, 4.2 mmol) and the resultant reaction mixture was stirred at ambient temperature for 14 h. After completion of reaction (TLC), the reaction mixture was diluted with water and extracted with EtOAc. The combined EtOAc layer was washed with water and brine then dried over Na2SO4 and concentrated under reduced pressure to afforded the title compound as a pale yellow solid (0.36 g, 45%): mp 170-172° C.; 1H NMR (300 MHz, DMSO-d6) δ 10.12 (s, 1H), 9.61 (s, 1H), 8.69 (s, 1H), 8.45 (d, J=9.3 Hz, 1H), 8.23 (d, J=9.3 Hz, 1H); ESIMS m/z 242.3 ([M−H]−); IR (thin film) 2238, 1705, 1551, 1314 cm−1.
Example 93
Preparation of 4-(3-Methyl-1H-1,2,4-triazol-1-yl)benzaldehyde (DI53)




To a stirring solution of 4-fluorobenzaldehyde (5.0 g, 40.32 mmol) in DMF (50 mL), were added K2CO3 (3.34 g, 40.32 mmol) and 3-methyl-1,2,4-trizole (3.34 g, 40.32 mmol) and the resultant reaction mixture was stirred at ambient temperature for 4 h. After completion of the reaction (TLC), the reaction mixture was diluted with water and extracted with EtOAc (3×). The combined EtOAc layer was washed with water and brine then dried over Na2SO4 and concentrated under reduced pressure to afforded the title compound as a white solid (4.1 g, 60%): mp 125-128° C.; 1H NMR (400 MHz, CDCl3) δ 10.05 (s, 1H), 8.76 (s, 1H), 8.02 (d, 2H), 7.85 (d, 2H), 2.50 (s, 3H); ESIMS m/z 188.04 ([M+H]+).
The following compound was made in accordance with the procedures disclosed in Example 93.
4-(1H-1,2,4-triazol-1-yl)-3-(trifluoromethyl)benzaldehyde (DI54)




The title compound was isolated as white solid (1.05 g, 60%): mp 81-83° C.; 1H NMR (400 MHz, CDCl3) δ 10.15 (s, 1H), 8.43 (s, 1H), 8.37 (s, 1H), 8.25 (d, J=7.2 Hz, 1H), 8.18 (s, 1H), 7.79 (d, J=7.2 Hz, 1H); ESIMS m/z 241.0 ([M]+).
4-(3-Nitro-1H-1,2,4-triazol-1-yl)benzaldehyde (DI55)




The title compound was isolated as pale yellow solid (0.10 g, 23%): mp 159-161° C.; 1H NMR (400 MHz, CDCl3) δ 10.10 (s, 1H), 8.89 (s, 1H), 8.15 (m, 2H), 8.00 (m, 2H); ESIMS m/z 217.11 ([M−H]−).
3-Bromo-4-(1H-1,2,4-triazol-1-yl)benzaldehyde (DI56)




The title compound was isolated as white solid (3.2 g, 51%): mp 126-128° C.; 1H NMR (400 MHz, CDCl3) δ 10.04 (s, 1H), 8.69 (s, 1H), 8.27 (M, 1H, 8.18 (s, 1H) 7.99 (d, J=9.2 Hz, 1H), 7.76 (d, J=9.2 Hz, 1H); ESIMS m/z 250.9 ([M]+).
5-Formyl-2-(3-methyl-1H-1,2,4-triazol-1-yl)benzonitrile (DI57)




The title compound was isolated as white solid (0.13 g, 30%): mp 147-149° C.; 1H NMR (400 MHz, CDCl3) δ 10.07 (s, 1H), 8.89 (s, 1H), 8.32 (d, J=1.8 Hz, 1H), 8.24 (dd, J=8.6, 1.3 Hz, 1H), 8.06 (d, J=8.6 Hz, 1H), 2.54 (s, 3H); ESIMS m/z 213.09 ([M+H]+); IR (thin film) 2239, 1697 cm−1.
3-Nitro-4-(1H-1,2,4-triazol-1-yl)benzaldehyde (DI58)




The title compound was isolated as pale yellow solid (3.0 g, 60%): mp 116-118° C.; 1H NMR (400 MHz, CDCl3) δ 10.15 (s, 1H), 8.48 (s, 1H), 8.46 (s, 1H), 8.26 (d, J=6.9 Hz, 1H), 8.16 (s, 1H), 7.83 (d, J=6.9 Hz, 1H); ESIMS m/z 219.00 ([M+H]+).
Example 94
Preparation of 1-(4-Vinylphenyl)-1H-1,2,4-triazole (DI59)




To a stirred solution of 4-[1,2,4]-triazol-1-yl-benzaldehyde (9.0 g, 52 mmol) in 1,4-dioxane (100 mL), were added K2CO3 (10.76 g, 78 mmol) and methyl triphenyl phosphonium bromide (22.2 g, 62.4 mmol) at room temperature. The resultant reaction mixture was heated to 70° C. for 18 h. After completion of the reaction (TLC), the reaction mixture was cooled to room temperature and filtered and the obtained filtrate was concentrated under reduced pressure. Purification by flash chromatography (SiO2, 100-200 mesh; 25-30% EtOAc in petroleum ether) to afforded the title compound as a white solid (5.6 g, 63%): ESIMS m/z 172.09 ([M+H]+).
The following compound was made in accordance with the procedures disclosed in Example 94.
1-(2-Methyl-4-vinylphenyl)-1H-1,2,4-triazole (DI60)




The title compound was isolated as an off white solid (1.5 g, 76%): 1H NMR (400 MHz, CDCl3) δ 8.25 (s, 1H), 8.11 (s, 1H), 7.35 (m, 2H), 7.27 (d, J=8.7 Hz, 1H), 6.74 (m, 1H), 5.82 (d, J=17.3 Hz, 1H), 5.36 (d, J=10.0 Hz, 1H), 2.25 (s, 3H); ESIMS m/z 186.14 ([M+H]+).
2-(1H-1,2,4-Triazol-1-yl)-5-vinylbenzonitrile (DI61)




The title compound was isolated as an off-white solid (1.40 g, 71%): mp 126-129° C.; 1H NMR (400 MHz, CDCl3) δ 8.76 (s, 1H), 8.18 (s, 1H), 7.82-7.84 (m, 1H), 7.72-7.80 (m, 2H), 6.70-6.80 (dd, J=17.6, 10.8 Hz, 1H), 5.90-5.95 (d, J=17.6 Hz, 1H), 5.50-5.70 (d, J=10.8 Hz, 1H); ESIMS m/z 197.03 ([M+H]+).
Example 95
Preparation of 2-(3-Nitro-1H-1,2,4-triazol-1-yl)-5-vinylbenzonitrile (DI62)




To a stirred solution of 5-formyl-2-(3-nitro-1H-1,2,4-triazol-1-yl)benzonitrile (0.36 g, 1.49 mmol) in 1,4-dioxane (25 mL), were added K2CO3 (0.3 g, 2.2 mmol) and methyl triphenyl phosphonium bromide (0.63 g, 1.79 mmol). The resultant reaction mixture was heated to 100° C. for 18 h. After completion of the reaction (TLC), the reaction mixture was cooled to room temperature and filtered and the obtained filtrate was concentrated under reduced pressure. Purification by flash chromatography (SiO2, 100-200 mesh; 25-30% EtOAc in petroleum ether) to afford the title compound as a solid (0.25 g, 70%): mp 103-105° C.; 1H NMR (400 MHz, DMSO-d6) δ 9.50 (s, 1H), 8.34 (m, 1H), 7.98 (d, J=7.8 Hz, 1H), 7.68 (d, J=7.8 Hz, 1H), 6.87 (m, 1H), 6.20 (d, J=15.7 Hz, 1H), 5.56 (d, J=11.8 Hz, 1H); ESIMS m/z 240.27 ([M−H]−); IR (thin film) 2240, 1514, 1312 cm−1.
The following compound was made in accordance with the procedures disclosed in Example 95.
1-(3-Chloro-4-vinylphenyl)-1H-1,2,4-triazole (DI63)




The title compound was isolated as an off-white solid (2.3 g, 80%): mp 134-137° C.; 1H NMR (400 MHz, CDCl3) δ 8.56 (s, 1H), 8.11 (s, 1H), 7.76 (s, 1H), 7.70 (d, J=9.0 Hz, 1H), 7.57 (d, J=9.0 Hz, 1H), 7.10 (m, 1H), 5.80 (d, J=17.2 Hz, 1H), 5.47 (d, J=12.4 Hz, 1H); ESIMS m/z 206.04 ([M+H]+.
3-Methyl-1-(4-vinylphenyl)-1H-1,2,4-triazole (DI64)




The title compound was isolated as a white solid (0.6 g, 60%): mp 109-111° C.; 1H NMR (400 MHz, CDCl3) δ 8.42 (s, 1H), 7.40-7.60 (m, 4H), 6.70-7.00 (dd, J=17.6, 10.8 Hz, 1H), 5.80 (d, J=17.6 Hz, 1H), 5.30 (d, J=17.6 Hz, 1H), 2.50 (s, 3H); ESIMS m/z 186.20 ([M+H]+).
1-(2-(Trifluoromethyl)-4-vinylphenyl)-1H-1,2,4-triazole (DI65)




The title compound was isolated as a colorless oil (0.6 g, 60%): 1H NMR (400 MHz, CDCl3) δ 8.32 (s, 1H), 8.14 (s, 1H), 7.84 (s, 1H), 7.72 (d, J=8.0 Hz, 1H), 7.50 (d, J=7.6 Hz, 1H), 6.70-6.90 (dd, J=17.6, 10.8 Hz, 1H), 5.90-6.00 (d, J=17.6 Hz, 1H), 5.50-5.80 (d, J=10.8 Hz 1H); ESIMS m/z 240.16 ([M+H]+).
3-Nitro-1-(4-vinylphenyl)-1H-1,2,4-triazole (DI66)




The title compound was isolated as a pale yellow solid (61 mg, 20%): mp 137-139° C.; 1H NMR (400 MHz, CDCl3) δ 8.60 (s, 1H), 7.68 (d, J=7.7 Hz, 2H), 7.60 (d, J=8.3 Hz, 2H), 6.77 (dd, J=17.7, 10.8, 1H), 5.87 (d, J=17.7 Hz, 1H), 5.42 (d, J=10.8 Hz, 1H); ESIMS m/z 217.28 ([M+H]+).
1-(2-Bromo-4-vinylphenyl)-1H-1,2,4-triazole (DI67)




The title compound was isolated as a white solid (1.2 g, 40%): mp 75-77° C.; 1H NMR (400 MHz, CDCl3) δ 8.48 (s, 1H), 8.12 (s, 1H), 7.75 (s, 1H) 7.42 (s, 2H), 6.70 (m, 1H), 5.83 (d, J=18 Hz, 1H), 5.42 (d, J=12 Hz, 1H); ESIMS m/z 249.1 ([M]+).
2-(3-Methyl-1H-1,2,4-triazol-1-yl)-5-vinylbenzonitrile (DI68)




The title compound was isolated as an off-white solid (0.6 g, 60%): mp 96-97° C.; 1H NMR (400 MHz, CDCl3) δ 8.66 (s, 1H), 7.80 (s, 1H), 7.74 (m, 2H), 6.73 (dd, J=17.6 Hz, 10.8 Hz, 1H), 5.88 (d, J=17.6 Hz, 1H), 5.49 (d, J=10.8 Hz, 1H), 2.52 (s, 3H); ESIMS m/z 211.10 ([M+H]+); IR (thin film) 2229 cm−1.
1-(2-Nitro-4-vinylphenyl)-1H-1,2,4-triazole (DI69) 




The title compound was isolated as a yellow solid (1.78 g, 60%): mp 102-104° C.; 1H NMR (400 MHz, CDCl3) δ 8.40 (s, 1H), 8.12 (s, 1H), 8.02 (s, 1H), 7.72-7.76 (d, J=8.0 Hz, 1H), 7.52-7.56 (d, J=17.6 Hz, 1H), 6.70-6.82 (dd, J=17.6, 10.8 Hz, 1H), 5.85-6.00 (d, J=17.6 Hz, 1H), 5.50-5.60 (d, J=10.8, Hz 1H); ESIMS m/z 217.0 ([M+H]+).
Example 96
Preparation of 3-Methyl-2-(1H-1,2,4-triazol-1-yl)-5-vinylbenzonitrile (DI70)




Step 1. 5-Bromo-2-fluoro-3-methylbenzaldehyde: To a stirred solution of di-isopropyl amine (4.01 g, 39.88 mmol) in THF (20 mL) was added n-BuLi (1.6 M in hexane) (19.9 mL, 31.91 mmol) at −78° C. slowly dropwise over the period of 10 min, the reaction mixture was stirred at −78° C. for 30 min A solution of 4-bromo-1-fluoro-2-methylbenzene (5.0 g, 26.6 mmol) in THF (30.0 mL) was added at −78° C., and the reaction mixture was stirred for 1 h at the same temperature. DMF (5.0 mL) was added and stirred at −78° C. for another 30 min. The reaction was monitored by TLC; then the reaction mixture was quenched with 1N HCl solution (aq) at 0° C. The aqueous layer was extracted with Et2O, washed with water and saturated brine solution. The combined organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to obtain the crude compound purified by flash column chromatography (SiO2, 100-200 mesh; eluting with 5% EtOAc/pet ether) to afford the title compound as a white solid (3.6 g, 64%); mp 48-50° C.: 1H NMR (400 MHz, CDCl3) δ 8.33 (s, 1H), 8.22 (s, 1H), 7.67 (s, 1H), 7.60 (s, 1H), 6.75 (dd, J=17.6, 10.8 Hz, 1H), 5.92 (dd, J=17.6, 10.8 Hz, 1H), 5.52 (d, J=17.6 Hz, 1H), 2.21 (s, 3H); ESIMS m/z 211.35 ([M−H]−).
Step 2. ((E)-5-Bromo-2-fluoro-3-methylbenzaldehyde oxime: To a stirred solution of 5-bromo-2-fluoro-3-methylbenzaldehyde (3.5 g, 16.2 mmol) in ethanol (50.0 mL) were added NaOAc (2.0 g, 24.3 mmol) and hydroxylamine hydrochloride (1.69 g, 24.3 mmol) at ambient temperature. The reaction mixture was stirred at ambient temperature for 3 h. The reaction mixture was concentrated on rotavapour to obtain crude compound, which was washed with water filtered and dried under vacuum to afford the title compound as a white solid: mp 126-127° C.; 1H NMR (400 MHz, CDCl3) δ 8.32 (s, 1H), 7.73 (d, J=2.4 Hz, 1H), 7.51 (s, 1H), 7.34 (d, J=2.4 Hz, 1H), 2.25 (s, 3H); ESIMS m/z 232.10 ([M+H]+).
Step 3. 5-Bromo-2-fluoro-3-methylbenzonitrile: A stirred solution of (E)-5-bromo-2-fluoro-3-methylbenzaldehyde oxime (0.5 g, 2.2 mmol) in acetic anhydride (5.0 mL) was heated to reflux for 18 h. The reaction mixture was diluted with water and extracted with EtOAc. The combined EtOAc layer was washed with brine and dried over Na2SO4 and concentrated under reduced pressure to afford the crude compound as a light brown gummy material (0.4 g, crude): ESIMS m/z 213.82 ([M+H]+).
Step 4. 5-Bromo-3-methyl-2-(1H-1,2,4-triazol-1-yl)benzonitrile (DI71): To a stirred solution of 5-bromo-2-fluoro-3-methylbenzonitrile (1.0 g, 47.716 mmol), in DMF (10.0 mL) was added K2CO3 (1.95 g, 14.14 mmol) followed by 1H-1,2,4-triazole (0.811 g, 9.433 mmol) at ambient temperature. The reaction mixture was heated to 140° C. for 18 h. The reaction mixture was cooled to ambient temperature, diluted with water and extracted with EtOAc (2×100 mL). The combined EtOAc layer was washed with brine and dried over Na2SO4 and concentrated under reduced pressure to afford the crude compound purified by flash column chromatography (SiO2, 100-200 mesh; eluting with 30% EtOAc/pet ether) to afford the title compound as a pink solid (0.6 g, 49%): 1H NMR (400 MHz, CDCl3) δ 8.39 (s, 1H), 8.23 (s, 1H), 7.91 (d, J=2.4 Hz, 2H), 2.21 (s, 3H), ESIMS m/z 262.57 ([M+H]+); IR (thin film) 2231, 554 cm−1.
Step 5. 3-Methyl-2-(1H-1,2,4-triazol-1-yl)-5-vinylbenzonitrile (DI70): A mixture of 5-bromo-3-methyl-2-(1H-1,2,4-triazol-1-yl)benzonitrile (0.6 g, 2.3 mmol), K2CO3 (0.95 g, 6.87 mmol), vinyl boronic anhydride (0.82 g, 3.43 mmol) and triphenylphosphine (0.13 g, 0.114 mmol) in toluene (20.0 mL) were stirred and degassed with argon for 30 min. The reaction mixture was heated to reflux for 18 h. The reaction mixture was cooled to ambient temperature, diluted with water and extracted with EtOAc (2×100 mL). The combined EtOAc layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure to afford the crude compound that was purified by flash column chromatography (SiO2, 100-200 mesh; eluting with 30% EtOAc/pet ether) to afford the title compound as a pink solid (0.25 g, 52%): 1H NMR (400 MHz, CDCl3) δ 8.33 (s, 1H), 8.22 (s, 1H), 7.67 (s, 1H), 7.60 (s, 1H), 6.75 (dd, J=17.6, 10.8 Hz, 1H), 5.92 (d, J=17.6, 1H), 5.52 (d, J=10.8 Hz, 1H), 2.21 (s, 3H), ESIMS m/z 211.35 ([M+H]+); IR (thin film) 2236, 1511 cm−1.
The following compound was made in accordance with the procedures disclosed in Steps 4 and 5 of Example 96.
1-(2-Fluoro-4-vinylphenyl)-1H-1,2,4-triazole (DI72)




1-(4-Bromo-2-fluorophenyl)-1H-1,2,4-triazole (DI73) was isolated as a pale yellow solid (3.0 g, 75%): mp 113-116° C.; 1H NMR (400 MHz, CDCl3) δ 8.69 (s, 1H), 8.13 (m, 2H), 7.50 (m, 1H), 7.21 (m, 1H); ESIMS m/z 241.93 ([M]+). The title compound (DI72) was isolated as a yellow solid (1.0 g, 71%): mp 67-70° C.; 1H NMR (400 MHz, CDCl3) δ 8.67 (s, 1H), 8.13 (s, 1H), 7.94 (m, 1H), 7.41 (m, 1H), 7.24 (s, 1H), 6.75 (dd, J=17.6, 10.8 Hz, 1H), 5.81 (d, J=17.6 Hz, 1H), 5.37 (d, J=10.8 Hz, 1H); ESIMS m/z 190.00 ([M+H]+).
Example 119
Preparation of 1-(1-(4-Vinylphenyl)-1H-1,2,4-triazol-5-yl)ethanone (DI78)




To a stirred solution of 1-(4-vinyl-phenyl)-1H-[1,2,4]-triazole (1 g, 5.8 mmol) in 25 mL of THF, was added n-BuLi (0.37 g, 5.8 mmol) at −78° C. and stirred for 30 min. To this N-methoxy-N-methyl acetamide in THF (0.66 g, 6.4 mmol) was added and the resultant reaction mixture was stirred at ambient temperature for 16 h. The reaction mixture was quenched with a saturated aqueous NH4Cl solution and extracted with EtOAc (3×50 mL). The combined EtOAc layer was washed with brine and dried over sodium sulphate and concentrated under reduced pressure. The crude compound was purified by flash chromatography (SiO2, 100-200 mesh, 40% EtOAc in Pet ether) to afford the title compound as an off white solid (280 mg, 23%): mp 97-98° C.; 1H NMR (400 MHz, CDCl3) δ 8.10 (s, 1H), 7.50 (d, 2H), 7.38 (d, 2H), 6.68 (dd, 1H), 5.85 (d, 1H), 5.38 (d, 1H), 2.75 (s, 3H); ESIMS m/z 214.14 ([M+H]+).
Example 120
Preparation of Cyclopropyl(1-(4-vinylphenyl)-1H-1,2,4-triazol-5-yl)methanone (DI79)




To a stirred solution of 1-(4-vinyl-phenyl)-1H-[1,2,4]-triazole (1 g, 5.8 mmol) in 25 mL of THF, was added n-BuLi (0.37 g, 5.8 mmol) at −78° C. and stirred for 30 min. To this N-methoxy N-methylcyclopropoxide in THF (0.82 g, 6.4 mmol) was added and the resultant reaction mixture was stirred at ambient temperature for 16 h. The reaction mixture was quenched with a saturated aqueous NH4Cl solution and extracted with EtOAc (3×25 mL). The combined EtOAc layer was washed with brine and dried over sodium sulphate and concentrated under reduced pressure. The crude compound was purified by flash chromatography (SiO2, 100-200 mesh, 40% EtOAc in Pet ether) to afford the title compound as an off white solid (420 mg, 30%): mp 90-91° C.; 1H NMR (400 MHz, CDCl3) δ 8.12 (s, 1H), 7.50 (d, J=7.8 Hz, 2H), 7.38 (d, J=7.8 Hz, 2H), 6.75 (dd, J=16.3, 10.7 Hz, 1H), 5.81 (d, J=16.3 Hz, 1H), 5.35 (d, J=10.7 Hz, 1H), 3.22 (m, 1H), 1.27 (m, 2H), 1.18 (m, 2H); ESIMS m/z 240.18 ([M+H]+); IR (thin film) 2922, 1630 cm−1.
Example 121
Preparation of 5-(Methylthio)-1-(4-vinylphenyl)-1H-1,2,4-triazole (DI80)




To a stirred solution of 1-(4-vinyl-phenyl)-1H-[1,2,4]-triazole (1 g, 5.8 mmol) in 50 mL of THF, was added n-BuLi (0.41 g, 6.4 mmol) at −78° C. and stirred for 30 min. To this dimethyldisulfide in THF (0.6 g, 6.43 mmol) was added and the resultant reaction mixture was stirred at ambient temperature for 16 h. The reaction mixture was quenched with a saturated aqueous NH4Cl solution and extracted with EtOAc (3×25 mL). The combined EtOAc layer was washed with brine and dried over sodium sulphate and concentrated under reduced pressure. The crude compound was purified by flash chromatography (SiO2, 100-200 mesh, 40% EtOAc in Pet ether) to afford the title compound as an off white solid (0.6 g, 48%): mp 68-70° C.; 1H NMR (400 MHz, CDCl3) δ 7.96 (s, 1H), 7.05 (m, 4H), 6.75 (dd, J=16.4, 10.7 Hz, 1H), 5.81 (d, J=16.4 Hz, 1H), 5.35 (d, J=10.7 Hz, 1H), 2.73 (s, 3H); ESIMS m/z 218.09 ([M+H]+).
Example 122
Preparation of 5-Methyl-1-(4-vinylphenyl)-1H-1,2,4-triazole (DI81)




To a stirred solution of 1-(4-vinyl-phenyl)-1H-[1,2,4]-triazole (0.5 g, 2.9 mmol) in 10 mL of THF, was added n-BuLi (0.22 g, 3.5 mmol) at −78° C. and stirred for 30 min. To this methyl iodide in THF (0.50 g, 3.5 mmol) was added and the resultant reaction mixture was stirred at ambient temperature for 16 h. The reaction mixture was quenched with a saturated aqueous NH4Cl solution and extracted with EtOAc (3×25 mL). The combined EtOAc layer was washed with brine and dried over sodium sulphate and concentrated under reduced pressure The crude compound was purified by flash chromatography (SiO2, 100-200 mesh, 40% EtOAc in Pet ether) afford the title compound as a pale brown liquid (250 mg, 46%): 1H NMR (400 MHz, CDCl3) δ 7.93 (s, 1H), 7.55 (d, J=9 Hz, 2H), 7.42 (d, J=9 Hz, 2H), 6.76 (dd, J=18, 11 Hz, 1H), 5.83 (d, J=18 Hz, 1H), 5.38 (d, J=11 Hz, 1H), 2.55 (s, 3H); ESIMS m/z 186.13 ([M+H]+); IR (thin film) 1517, 1386, 1182, 847 cm−1.
Example 97
Preparation of (E)-1-(4-(3-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)phenyl)-1H-1,2,4-triazole (DC1)




To a stirred solution of 1-(1-bromo-2,2,2-trifluoro-ethyl)-3,5-dichloro-benzene (2.0 g, 6.51 mmol) in 1,2-dichlorobenzene (25 mL), were added 1-(4-vinyl-phenyl)-1H-[1,2,4]triazole (2.22 g, 13.0 mmol), CuCl (64 mg, 0.65 mmol) and 2,2-bipyridyl (0.2 g, 1.3 mmol). The resultant reaction mixture was degassed with argon for 30 min, then stirred at 180° C. for 24 h. After completion of reaction (TLC), the reaction mixture was cooled to ambient temperature and filtered and the filtrate concentrated under reduced pressure. Purification by flash chromatography (SiO2, 100-200 mesh; 25-30% EtOAc in petroleum ether) afforded the title compound as an off-white solid (0.8 g, 32%): mp 93-97° C.; 1H NMR (300 MHz, CDCl3) δ 8.56 (s, 1H), 8.11 (s, 1H), 7.68 (d, J=8.4 Hz, 2H), 7.54 (d, J=8.4 Hz, 2H), 7.38 (t, J=1.8 Hz, 1H), 7.29 (s, 2H), 6.62 (d, J=15.6 Hz, 1H), 6.42 (dd, J=15.6, 8.2 Hz, 1H), 4.15 (m, 1H); ESIMS m/z 398.05 ([M+H]+).
Compounds DC2-DC37, DC44, DC45, DC47-49, DC50, DC51, DC54, DC58, DC60, DC62, and DC63-DC67 in Table 1 were made in accordance with the procedures disclosed in Example 97.
Example 98
Preparation of (E)-2-(3-Nitro-1H-1,2,4-triazol-1-yl)-5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzonitrile (DC40)




To a stirred solution of 2-(3-nitro-1H-1,2,4-triazol-1-yl)-5-vinylbenzonitrile (0.9 g, 3.7 mmol) in 1,2-dichlorobenzene (10 mL), were added 5-(1-bromo-2,2,2-trifluoroethyl)-1,2,3-trichlorobenzene (2.5 g, 7.5 mmol), CuCl (73 mg, 0.74 mmol) and 2,2-bipyridyl (0.23 g, 1.49 mmol) and the resultant reaction mixture was degassed with argon for 30 min and then stirred at 180° C. for 14 h. After completion of the reaction (TLC), the reaction mixture was cooled to ambient temperature and filtered and the filtrate was concentrated under reduced pressure. Purification by flash chromatography (SiO2, 100-200 mesh, 25-30% EtOAc in Pet ether) afforded the title compound as an off white solid (0.9 g, 50%): mp 70-73° C.; 1H NMR (300 MHz, CDCl3) δ 8.86 (s, 1H), 7.88 (m, 3H), 7.44 (s, 2H), 6.67 (d, J=16.0 Hz, 1H), 6.56 (dd, J=16.0, 7.6 Hz, 1H), 4.19 (m, 1H); ESIMS m/z 436.11 ([M−H]−).
Example 99
Preparation of (E)-2-(3-Amino-1H-1,2,4-triazol-1-yl)-5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzonitrile (DC41)




To a stirred solution of (E)-2-(3-nitro-1H-1,2,4-triazol-1-yl)-5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzonitrile (0.6 g, 1.2 mmol) in MeOH (10 mL), were added Zn dust (0.39 g, 5.98 mmol) and saturated aqueous NH4Cl solution (5 mL) and the resultant reaction mixture was stirred at ambient temperature for 2 h. After completion of the reaction (TLC), the reaction mass was concentrated under reduced pressure. The reaction mass was diluted with CH2Cl2, filtered through a Celite® bed, and the obtained filtrate concentrated under reduced pressure to afford the title compound as a solid (0.5 g, 89%): mp 72-75° C.; 1H NMR (300 MHz, DMSO-d6) δ 8.72 (s, 1H), 8.26 (s, 1H), 8.01 (d, J=8.4 Hz, 1H), 7.91 (s, 2H), 7.77 (d, J=8.4 Hz, 1H), 6.42 (dd, J=15.6, 9.2 Hz, 1H), 6.83 (d, J=15.6 Hz, 1H), 5.87 (s, 2H), 4.89 (m, 1H); ESIMS m/z 469.95 ([M−H]−).
Compound DC38 in Table 1 was made in accordance with the procedures disclosed in Example 99. Also, compound DC55 in Table 1 was made from compound DC54 in accordance with the procedures disclosed in Example 99, with the exception of using ammonium formate in place of NH4Cl.
Example 100
Preparation of (E)-N-(1-(2-Cyano-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)phenyl)-1H-1,2,4-triazol-3-yl)-N-(cyclopropanecarbonyl)cyclopropanecarboxamide (DC42)




To a stirred solution of (E)-2-(3-amino-1H-1,2,4-triazol-1-yl)-5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzonitrile (0.1 g, 0.21 mmol) in CH2Cl2 at ambient temperature, was added cyclopropylcarbonyl chloride (0.045 g, 0.42 mmol) and the reaction mixture was stirred for 2 h at ambient temperature. The reaction mixture was diluted with CH2Cl2 and washed with water and brine and dried over Na2SO4. Concentration under reduced pressure and purification by preparative HPLC afforded the title compound as a solid (0.09 g, 79%): mp 104-107° C.; 1H NMR (300 MHz, CDCl3) δ 8.78 (s, 2H), 7.83 (s, 1H), 7.80 (m, 2H), 7.42 (s, 2H), 6.65 (d, J=16.4 Hz, 1H), 6.51 (dd, J=7.6, 8.0 Hz, 1H), 4.17 (m, 1H), 2.16 (m, 2H), 1.25 (m, 4H), 1.00 (m, 4H); ESIMS m/z 609.98 ([M+H]+); IR (thin film) 2234, 1714, 1114, 807 cm−1.
Example 101
Preparation of (E)-N-(1-(2-Cyano-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)phenyl)-1H-1,2,4-triazol-3-yl)cyclopropanecarboxamide (DC43)




To a stirred solution of (E)-2-(3-amino-1H-1,2,4-triazol-1-yl)-5-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzonitrile (0.15 g, 0.31 mmol) in CH2Cl2 at 0° C., were added TEA (0.1 g, 1 mmol) and cyclopropylcarbonyl chloride (0.04 g, 0.38 mmol) and the reaction mixture was stirred for 1 h at 0° C. The reaction mixture was diluted with CH2Cl2 and washed with water and brine and dried over Na2SO4. Concentration under reduced pressure and purification by column chromatography (SiO2, 100-200 mesh) afforded the title compound as a solid (66 mg, 34%): mp 109-112° C.; 1H NMR (300 MHz, DMSO-d6) δ 10.94 (br s, 1H), 8.36 (s, 1H), 8.08 (m, J=8.4 Hz, 1H), 7.91 (s, 2H), 7.84 (d, J=8.4 Hz, 1H), 7.13 (dd, J=15.6, 9.2 Hz, 1H), 6.87 (d, J=15.6 Hz, 1H), 4.92 (m, 1H), 1.99 (br s, 1H), 0.82 (s, 4H); ESIMS m/z 540.04 ([M+H]+); IR (thin film) 3233, 2233, 1699, 1114, 807 cm−1.
Compound DC39 in Table 1 was made in accordance with the procedures disclosed in Example 101.
Example 102
Preparation of 1-(4-(1H-1,2,4-triazol-1-yl)phenyl)ethanone (DI74)




To a stirred solution of 4-bromoacetophenone (10 g, 50 mmol) in DMF (100 mL), were added 1,2,4-triazole (5 g, 75 mmol), Cs2CO3 (32.6 g, 100.5 mmol) and CuI (1.4 g, 10.1 mmol) and the resultant reaction mixture was refluxed for 48 h. After completion of the reaction (by TLC), the reaction mixture was cooled to ambient temperature and diluted with water (200 mL) and extracted with EtOAc. The combined organic layer was washed with brine and dried over Na2SO4 and concentrated under reduced pressure. Purification by washing with Et2O afforded the title compound as a solid (5 g, 96%): 1H NMR (400 MHz, CDCl3) δ 8.71 (s, 1H), 8.16, (s, 1H), 8.13 (d, J=8.6 Hz, 2H), 7.83 (d, J=8.6 Hz, 2H), 2.66 (s, 3H); ESIMS m/z 186.02 ([M−H]−).
Example 103
Preparation of 1-(4-(1H-1,2,4-triazol-1-yl)phenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluorobutan-1-one (DI75)




Step 1. 1-(4-(1-(Trimethylsilyloxy)vinyl)phenyl)-1H-1,2,4-triazole (DI76) To a stirred solution of 1-(4-(1H-1,2,4-triazol-1-yl)phenyl)ethanone (4.5 g, 24.0 mmol) in CH2Cl2 at 0° C., were added TEA (3.7 g, 36.1 mmol) and trimethylsilyl trifluoromethanesulfonate (8 g, 36 mmol) and the resultant reaction mixture was stirred for 1 h. The reaction mixture was quenched with a mixture of sat aqueous NaHCO3 solution and ether. The ether layer and was separated, washed with brine, dried over Na2SO4 and concentrated under reduced pressure to afford the title compound (5.5 g) which was taken directly to next step.
Step 2. 1-(4-(1H-1,2,4-Triazol-1-yl)phenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluorobutan-1-one (DI75): To a stirred solution of 1-(4-(1-(trimethylsilyloxy)vinyl)phenyl)-1H-1,2,4-triazole (6 g, 23 mmol) and 1-(1-bromo-2,2,2-trifluoro-ethyl)-3,5-dichlorobenzene (7.1 g, 34.7 mmol) in 1,2-dichlorobenzene (30 mL) was degassed with argon. To this CuCl (0.23 g, 2.31 mmol) and 2,2-bipyridyl (0.73 g, 4.63 mmol) was added to the above reaction mixture and the resultant reaction mixture was heated to 180° C. for 18 h. After completion of the reaction (by TLC), the reaction mixture was absorbed onto silica gel and purified by column chromatography (SiO2; 10% EtOAc in petroleum ether) to afford title compound as a solid (3 g, 31%): 1H NMR (400 MHz, CDCl3) δ 8.67 (s, 1H), 8.15 (s, 1H), 8.10 (d, J=8.3 Hz, 2H), 7.82 (d, J=8.3 Hz, 2H), 7.33 (m, 1H), 7.30 (m, 2H), 4.20 (m, 1H), 3.63 (m, 2H); ESIMS m/z 412. 14 ([M−H]−).
Example 104
Preparation of 2-(4-(1H-1,2,4-triazol-1-yl)phenyl)-4-(3,5-dichlorophenyl)-5,5,5-trifluoropentan-2-ol (DI77)




To a solution of 1-(4-(1H-1,2,4-triazol-1-yl)phenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluorobutan-1-one (300 mg, 0.726 mmol) in THF cooled to 0° C. was added methylmagnesium bromide (450 mg, 5 mmol) drop wise. The reaction was stirred for 3 h at 0° C., then the reaction mixture was quenched with sat aqueous NH4Cl solution and extracted with EtOAc. The combined EtOAc layer was washed with water and brine, dried over Na2SO4 and concentrated under reduced pressure. Purification by column chromatography (SiO2, 100-200 mesh; 20%-25% EtOAc in petroleum ether) afforded the title compound as a solid (100 mg, 32%): 1H NMR (400 MHz, CDCl3) δ two diastereoisomers 8.58 (s, 1H, minor), 8.48 (s, 1H, major), 8.13 (s, 1H, minor), 8.09 (s, 1H, major), 7.70 (d, J=9.0 Hz, 2H, minor), 7.53 (d, J=9.0 Hz, 2H, minor), 7.40 (d, J=9.0 Hz, 2H, major), 7.31 (m, 1H, minor), 7.27 (d, J=9.0 Hz, 2H, major), 7.20 (m, 2H, minor), 7.01 (m, 1H, major), 6.75 (m, 2H, major), 350 (m, 1H), 2.50 (m, 2H), 1.56 (s, 3H, major), 1.54 (s, 3H, minor); ESIMS m/z 430.05 ([M+H]+).
Example 105
Preparation of (E)-1-(4-(4-(3,5-Dichlorophenyl)-5,5,5-trifluoropent-2-en-2-yl)phenyl)-1H-1,2,4-triazole (DC68)




To a solution of 2-(4-(1H-1,2,4-triazol-1-yl)phenyl)-4-(3,5-dichlorophenyl)-5,5,5-trifluoropentan-2-ol (100 mg, 0.233 mmol) in toluene was added a catalytic amount of p-toluenesulfonic acid and the water was removed by azeotropic distillation over the course of 12 h. The reaction mixture was cooled to room temperature and dissolved in EtOAc. The solution was washed with sat aqueous NaHCO3 solution and brine, dried over Na2SO4 and concentrated under reduced pressure. Purification by column chromatography (SiO2, 100-200 mesh; 20%-25% EtOAc in petroleum ether) afforded the title compound as a solid (30 mg, 31%).
Example 123
Preparation of (E)-5-(3-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(1H-1,2,4-triazol-1-yl)benzaldehyde (DC52)




To a stirred solution of (E)-5-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(1H-1,2,4-triazol-1-yl)benzonitrile (0.3 g, 0.71 mmol) in toluene (10 mL) at −78° C. was added dropwise diisobutylaluminum hydride (DIBAL-H, 1.0 M solution in toluene; 0.85 mL), and the reaction mixture was stirred at −78° C. for 20 min. The reaction mixture was quenched with the addition of 1 N HCl solution, then the aqueous layer was extracted with EtOAc (2×). The combined organic layers were washed with brine, dried over Na2SO4 and concentrated under reduced pressure. The crude compound was purified by flash column chromatography (SiO2; 50% EtOAc/Pet ether) to afford the title compound as a yellow oil.
Compound DC53 in Table 1 was made in accordance with the procedures disclosed in Example 123.
Example 124
Preparation of (E)-5-(3-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-N-methyl-2-(1H-1,2,4-triazol-1-yl)aniline (DC57)




To a stirred solution of (E)-5-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(1H-1,2,4-triazol-1-yl)aniline (0.3 g, 0.7 mmol) in CH2Cl2 (10 mL) was added TEA (0.155 mL, 1.09 mmol) and methyl iodide (0.124 g, 0.873 mmol). The reaction was stirred at ambient temperature for 18 h. The CH2Cl2 layer was washed with water and brine, dried over Na2SO4 and concentrated under reduced pressure. The crude compound was purified by flash column chromatography (SiO2; 50% EtOAc/Pet ether) to afford the title compound as a yellow semi-solid (0.07 g, 70%).
Example 125
Preparation of (E)-5-(3-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(1H-1,2,4-triazol-1-yl)benzoic acid (DC61) 




A solution of (E)-ethyl 5-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(1H-1,2,4-triazol-1-yl)benzoate (0.2 g, 0.4 mmol) in 6 N HCl (10 mL) was stirred at 100° C. for 18 h. The reaction was cooled to ambient temperature, resulting in a white solid precipitate. The precipitate was filtered to afford the title compound as a white solid (0.12 g, 60%).
Example 126
Preparation of (Z)-5-(E)-3-(3,5-Dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-N′-hydroxy-2-(1H-1,2,4-triazol-1-yl)benzimidamide (DC59)




A solution of (E)-5-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(1H-1,2,4-triazol-1-yl)benzonitrile (0.3 g, 0.71 mmol), NaOAc (0.087 g, 1.065 mmol) and hydroxylammonium chloride (0.072 g, 1.065 mmol) in 9:1 ethanol/water mixture (10 mL) was stirred at 70° C. for 8 h. The reaction was cooled to ambient temperature, and the ethanol was evaporated. The residue was dissolved in water and extracted with EtOAc (2×). The combined organic layers were washed with brine, dried over Na2SO4 and concentrated under reduced pressure to afford the title compound as an off white solid.
Example 127
Preparation of (E)-1-(4-(3-(3,5-Dichlorophenyl)-4,4,4-trifluoro-3-methoxybut-1-en-1-yl)phenyl)-1H-1,2,4-triazole (DC70)




Step 1. (E)-3-(4-(1H-1,2,4-triazol-1-yl)phenyl)-1-(3,5-dichlorophenyl)prop-2-en-1-one: To a solution of 1-(3,5-dichlorophenyl)ethanone (0.5 g, 2.6 mmol) in ethanol (20 mL) was added 4-(1H-1,2,4-triazol-1-yl)benzaldehyde (0.46 g, 2.65 mmol) and the reaction was cooled to 0° C. NaOH (0.22 g, 5.29 mmol) in water (10 mL) was then added and the reaction was allowed to stir for 2 h at 0° C. The reaction was extracted with EtOAc and the combined organic layers were dried over Na2SO4 and concentrated under reduced pressure to afford the title compound (0.149 g, 17%):); ESIMS m/z 430.05 ([M+H]+) 344.08
Step 2. (E)-4-(4-(1H-1,2,4-triazol-1-yl)phenyl)-2-(3,5-dichlorophenyl)-1,1,1-trifluorobut-3-en-2-ol (DC69): To a solution of (E)-3-(4-(1H-1,2,4-triazol-1-yl)phenyl)-1-(3,5-dichlorophenyl)prop-2-en-1-one (1 g, 3 mmol) in THF (150 mL) was added trifluoromethyltrimethylsilane (0.517 g, 3.644 mmol) and tetra-n-butylammonium fluoride (TBAF) (1.0 M, 1 mL) at 0° C. The reaction was slowly warmed to ambient temperature and allowed to stir for 2 h. The reaction was then cooled to 0° C. and 5 M HCl solution was added and the reaction was stirred for an additional 4 h at ambient temperature. The reaction was extracted with CH2Cl2 and the combined organic layers were dried over Na2SO4 and concentrated under reduced pressure. The crude compound was purified by flash column chromatography (SiO2; 25% EtOAc/hexanes) to afford the title compound as an off-white solid (0.3 g, 25%).
Step 3. (E)-1-(4-(3-(3,5-Dichlorophenyl)-4,4,4-trifluoro-3-methoxybut-1-en-1-yl)phenyl)-1H-1,2,4-triazole (DC70): To a solution of (E)-4-(4-(1H-1,2,4-triazol-1-yl)-phenyl)-2-(3,5-dichlorophenyl)-1,1,1-trifluorobut-3-en-2-ol (0.15 g, 0.36 mmol) in THF (5 mL) was added NaH (60%, 10 mg, 0.44 mmol) at 0° C. The reaction was allowed to stir at 0° C. for 30 min, then methyl iodide (61 mg, 0.44 mmol) was added slowly and the reaction was warmed to ambient temperature and allowed to stir for 4 h. The reaction was quenched with aqueous NH4Cl solution and extracted with CH2Cl2. The combined organic layers were dried over Na2SO4 and concentrated under reduced pressure to afford the title compound as an off-white solid (55 mg, 35%).
Example 128
Preparation of tert-Butyl (2-methyl-1-oxo-1-((2,2,2-trifluoroethyl)amino)propan-2-yl)carbamate




To a stirred solution of 2-((tert-butoxycarbonyl)amino)-2-methylpropanoic acid (4.58 g, 22.6 mmol) in methylene chloride (50 mL) was added EDC HCl (4.75 g, 24.8 mmol) followed by 2,2,2-trifluoroethylamine (2.67 g, 27.0 mmol) and DMAP (3.03 g, 24.8 mmol). The reaction mixture was stirred at ambient temperature for 18 h, then washed with aqueous 5% NaHSO4 (2×), aqueous 10% HCl (1×) and aqueous saturated NaHCO3 (2×). The organic phase was dried (MgSO4) and concentrated in vacuo to afford the title compound as a white solid (2.97 g, 46%).
The following molecules were made in accordance with the procedures disclosed in Example 128:
(S)-tert-Butyl (1-oxo-1-((2,2,2-trifluoroethyl)amino)butan-2-yl)carbamate




The title molecule was isolated as a white solid: mp 108-111° C.; 1H NMR (400 MHz, CDCl3) δ 6.90 (s, 1H), 5.04 (m, 1H), 4.07 (m, 1H), 3.92 (m, 3H), 1.87 (m, 1H), 1.66 (m, 1H), 1.44 (s, 9H), 0.96 (t, J=7.4 Hz, 3H); 19F NMR (376 MHz, CDCl3) δ −72.54; 13C NMR (101 MHz, CDCl3) δ 173.05, 156.04, 124.03 (q, J=278.5 Hz), 80.30, 55.56, 40.43 (q, J=34.7 Hz), 28.19, 25.63, 9.80; [α]D=−33.3 (c, 10.1 mg/mL in CH2Cl2).
tert-Butyl (1-oxo-1-((2,2,2-trifluoroethyl)amino)butan-2-yl)carbamate




The title molecule was isolated as a white solid: mp 113-116° C.; 1H NMR (400 MHz, CDCl3) δ 7.36 (d, J=8.4 Hz, 1H), 5.43-5.25 (m, 1H), 4.16 (m, 1H), 3.98 (m, 1H), 3.82 (m, 1H), 1.84 (dt, J=14.0, 7.0 Hz, 1H), 1.66 (dt, J=14.2, 7.3 Hz, 1H), 1.44 (s, 9H), 0.95 (t, J=7.3 Hz, 3H); 19F NMR (376 MHz, CDCl3) δ −72.51; 13C NMR (101 MHz, CDCl3) δ 172.94, 156.02, 124.47 (q, J=380.8 Hz), 80.33, 55.54, 40.46 (q, J=34.8 Hz), 28.19, 25.61, 9.79.
tert-Butyl (2-oxo-2-((1,1,1-trifluoropropan-2-yl)amino)ethyl)carbamate




The title molecule was isolated as a white solid: mp 84-88° C.; 1H NMR (400 MHz, CDCl3) δ 6.89 (s, 1H), 5.44 (t, J=5.8 Hz, 1H), 4.77-4.48 (m, 1H), 3.83 (d, J=5.9 Hz, 2H), 1.45 (s, 9H), 1.33 (d, J=7.0 Hz, 3H); 19F NMR (376 MHz, CDCl3) δ −77.63; 13C NMR (101 MHz, CDCl3) δ 169.84, 156.33, 125.19 (q, J=280.9 Hz), 80.29, 46.20 (q, J=31.7 Hz), 44.15, 28.11, 13.88; EIMS m/z 270 ([M]+).
(R)-tert-Butyl (1-((2-fluoroethyl)amino)-1-oxopropan-2-yl)carbamate




The title molecule was isolated as a white solid: mp 91-94° C.; 1H NMR (300 MHz, DMSO-d6) δ 7.98 (bs, 1H), 6.87 (t, J=7.2 Hz, 1H), 4.47 (t, J=4.8 Hz, 1H), 4.32 (t, J=5.1 Hz, 1H), 3.97-3.92 (m, 1H), 3.41-3.37 (m, 1H), 3.33-3.28 (m, 1H), 1.37 (s, 9H), 1.16 (d, J=7.3 Hz, 3H); ESIMS m/z 235.0 ([M+H]+).
tert-Butyl (3-oxo-3-((2,2,2-trifluoroethyl)amino)propyl)carbamate




The title molecule was isolated as a white solid: mp 123-125° C.; 1H NMR (400 MHz, CDCl3) δ 6.42-6.22 (m, 1H), 5.07 (s, 1H), 3.92 (qd, J=9.1, 6.4 Hz, 2H), 3.43 (q, J=6.2 Hz, 2H), 2.50 (t, J=6.0 Hz, 2H), 1.43 (s, 9H); 19F NMR (376 MHz, CDCl3) δ −72.50; 13C NMR (101 MHz, CDCl3) δ 171.76, 156.30, 124.02 (q, J=278.5 Hz), 79.67, 40.53 (q, J=34.8 Hz), 36.41, 36.27, 28.31.
(R)-tert-Butyl (1-(ethylamino)-1-oxopropan-2-yl)carbamate




The title molecule was isolated as a white solid: mp 88-93° C.; 1H NMR (400 MHz, CDCl3) δ 6.35 (s, 1H), 5.25-5.04 (m, 1H), 4.21-3.99 (m, 1H), 3.29 (dd, J=7.5, 5.9 Hz, 2H), 1.45 (s, 8H), 1.35 (d, J=7.0 Hz, 3H), 1.13 (t, J=7.3 Hz, 3H); 13C NMR (101 MHz, CDCl3) δ 172.79, 155.51, 79.59, 49.97, 34.16, 28.25, 18.77, 14.60.
(R)-tert-Butyl (1-oxo-1-((3,3,3-trifluoropropyl)amino)propan-2-yl)carbamate




The title molecule was isolated as an off white solid: mp 101-105° C.; 1H NMR (300 MHz, DMSO-d6) δ 7.96 (bs, 1H), 6.90 (d, J=6.9 Hz, 1H), 3.91-3.86 (m, 1H), 3.34-3.19 (m, 2H), 2.50-2.32 (m, 2H), 1.37 (s, 9H), 1.15 (d, J=7.2 Hz, 3H).
(R)-tert-Butyl (1-oxo-1-((2,2,2-trifluoroethyl)amino)pentan-2-yl)carbamate




The title molecule was isolated as a white solid: mp 107-122° C.; 1H NMR (400 MHz, CDCl3)) δ 6.90 (s, 1H), 5.00 (d, J=8.0 Hz, 1H), 4.12 (d, J=7.3 Hz, 1H), 3.99-3.76 (m, 2H), 1.87-1.73 (m, 1H), 1.65-1.52 (m, 1H), 1.44 (s, 9H), 1.38 (m, 2H), 0.94 (t, J=7.3 Hz, 3H); 19F NMR (376 MHz, CDCl3) δ rotomer −72.55, −73.27; 13C NMR (101 MHz, CD3OD) δ rotomers 176.08, 157.86, minor 126.13 (q, J=279.8 Hz), major 125.83 (q, J=278.8 Hz), 80.65, 55.90, minor 42.27 (q, J=35.4 Hz), major 41.24 (q, J=35.4 Hz), 35.50, 28.73, 20.04, 14.03.
(R)-Benzyl (3-methyl-1-oxo-1-((2,2,2-trifluoroethyl)amino)butan-2-yl)carbamate




The title molecule was isolated as a white solid: mp 157-161° C.; 1H NMR (400 MHz, CDCl3) δ 7.46-7.31 (m, 5H), 6.57 (d, J=8.3 Hz, 1H), 5.34 (d, J=8.9 Hz, 1H), 5.11 (s, 2H), 4.02 (dq, J=16.1, 8.8, 7.7 Hz, 2H), 3.78 (td, J=9.0, 4.7 Hz, 1H), 2.15 (q, J=6.7 Hz, 1H), 0.97 (d, J=6.8 Hz, 3H), 0.94 (d, J=6.8 Hz, 3H); 19F NMR (376 MHz, CDCl3) δ −72.44.
Example 129
Preparation of N-(2,2,2-Trifluoroethyl) 1-amino-2-methylpropanecarboxamide hydrochloride




To tert-butyl (2-methyl-1-oxo-1-((2,2,2-trifluoroethyl)amino)propan-2-yl)carbamate (2.61 g, 9.18 mmol) in methylene chloride (20 mL) was added 4 M HCl in dioxane (20 mL). The solution was stirred for 6 h at ambient temperature. The reaction mixture was concentrated in vacuo to afford the title compound as a white solid (2.18 g).
The following molecules were made in accordance with the procedures disclosed in Example 129:
(R)-1-Oxo-1-((2,2,2-trifluoroethyl)amino)propan-2-aminium chloride




The title molecule was isolated as a white solid: mp 210-213° C.; 1H NMR (400 MHz, DMSO-d6) δ 9.22 (t, J=6.3 Hz, 1H), 8.37-8.27 (m, 3H), 4.07-3.95 (m, 2H), 3.95-3.84 (m, 1H), 1.38 (d, J=7.0 Hz, 3H); 19F NMR (376 MHz, DMSO-d6) δ −70.75; lab=−6.6 (c, 5.0 mg/mL in MeOH).
1-Oxo-1-((2,2,2-trifluoroethyl)amino)butan-2-aminium chloride 




The title molecule was isolated as a white solid: 1H NMR (300 MHz, DMSO-d6) δ 9.12 (t, J=5.7 Hz, 1H), 8.19 (s, 3H), 4.14-3.93 (m, 2H), 3.78 (t, J=6.0 Hz, 1H), 1.81-1.71 (m, 2H), 0.88 (t, J=7.2 Hz, 3H); ESIMS m/z 184.90 ([M-TFA)+H]+); IR (thinfilm) 3269, 1681, 1158 cm−1.
2-Oxo-2-((1,1,1-trifluoropropan-2-yl)amino)ethanaminium chloride




The title molecule was isolated as a white solid: 1H NMR (300 MHz, DMSO-d6) δ 8.96 (d, J=8.7 Hz, 1H), 8.09 (bs, 3H), 4.71-4.59 (m, 1H), 3.64-3.62 (m, 2H), 1.27 (d, J=6.9 Hz, 3H); EIMS m/z 170.1 ([M]+).
(R)-1-((2-Fluoroethyl)amino)-1-oxopropan-2-aminium chloride




The title molecule was isolated as a white solid: 1H NMR (300 MHz, DMSO-d6) δ 8.76 (t, J=5.1 Hz, 1H), 8.21 (bs, 3H), 4.54 (t, J=5.1 Hz, 1H), 4.38 (t, J=4.8 Hz, 1H), 3.85-3.79 (m, 1H), 3.50-3.45 (m, 1H), 3.41-3.36 (m, 1H), 1.36 (d, J=7.2 Hz, 3H); ESIMS m/z 135.1 ([M+H]+); IR (thinfilm) 3331, 2983, 1660, 1161, 597 cm−1.
3-Oxo-3-((2,2,2-trifluoroethyl)amino)propan-1-aminium chloride




The title molecule was isolated as a white solid: mp 193-197° C.; 1H NMR (400 MHz, DMSO-d6) δ 8.94 (t, J=6.4 Hz, 1H), 8.16 (s, 3H), 3.99-3.79 (m, 2H), 2.98 (t, J=7.3 Hz, 2H), 2.64 (t, J=7.3 Hz, 2H); 19F NMR (376 MHz, DMSO-d6) δ −70.74.
(R)-1-(Ethylamino)-1-oxopropan-2-aminium chloride




The title molecule was isolated as a white solid: mp 223-236° C.; 1H NMR (400 MHz, DMSO-d6) δ 8.65 (t, J=5.4 Hz, 1H), 8.32 (s, 3H), 3.89-3.66 (m, 1H), 3.12 (p, J=7.0 Hz, 2H), 1.35 (d, J=6.9 Hz, 3H), 1.05 (t, J=7.2 Hz, 3H); 13C NMR (101 MHz, DMSO-d6) δ 168.98, 48.08, 33.54, 17.16, 14.43.
(R)-1-Oxo-1-((3,3,3-trifluoropropyl)amino)propan-2-aminium chloride




The title molecule was isolated as an off white solid: mp 128-131° C.; 1H NMR (300 MHz, DMSO-d6) δ 8.62 (bs, 1H), 8.10 (bs, 3H), 3.82-3.79 (m, 1H), 3.50-3.38 (m, 2H), 2.50-2.37 (m, 2H), 1.34 (d, J=6.9 Hz, 3H).
(R)-1-Oxo-1-((2,2,2-trifluoroethyl)amino)pentan-2-aminium chloride




The title molecule was isolated as a white solid: mp 204-210° C.; 1H NMR (400 MHz, CD3OD) δ 4.17-4.00 (m, 1H), 3.98-3.69 (m, 2H), 1.83 (dt, J=15.0, 7.5 Hz, 2H), 1.50-1.35 (m, 2H), 0.99 (t, J=7.3 Hz, 3H); 19F NMR (376 MHz, CD3OD) δ −73.90; 13C NMR (101 MHz, CD3OD) δ 170.97, 125.72 (q, J=277.9 Hz), 54.37, 41.30 (q, J=34.7 Hz), 34.65, 19.00, 13.94.
Example 130
Preparation of (R)-tert-Butyl 1-thioxo-1-(2,2,2-trifluoroethylamino)propan-2-ylcarbamate




To a stirred solution of (R)-tert-butyl 1-oxo-1-(2,2,2-trifluoroethylamino)propan-2-ylcarbamate (100 mg, 0.37 mmol) in CH2Cl2 (10 mL) was added P2S5 (24 mg, 0.11 mmol) and hexamethyldisiloxane (HMDO) (0.13 mL, 0.59 mmol) at room temperature and the mixture was refluxed for 3 h. The reaction mixture was cooled to room temperature and another portion of P2S5 (24 mg, 0.11 mmol) was added and the resulting mixture was refluxed for 18 h. The volatiles were evaporated, pentane (25 mL) was added to the residue and stirred for 10-15 min. The pentane layer was decanted, concentrated in vacuo and the residue was passed through a short silica pad eluting with pentane followed by CH2Cl2 to give the title compound as colorless liquid (30 mg, 30%): 1H NMR (400 MHz, DMSO-d6) δ 10.27 (t, J=5.4 Hz, 1H), 7.00 (d, J=6.8 Hz, 1H), 4.57-4.35 (m, 3H), 1.32 (s, 9H), 1.25 (d, J=7.6 Hz, 3H); ESIMS m/z 286.2 ([M+H]+); IR (thin film) 3233, 1683, 1257 cm−1.
Example 131
Preparation of (R)-1-Thioxo-1-((2,2,2-trifluoroethyl)amino)propan-2-aminium 2,2,2-trifluoroacetate




To a stirred solution of (R)-tert-butyl 1-thioxo-1-(2,2,2-trifluoroethylamino)propan-2-ylcarbamate (200 mg, 0.69 mmol) in CH2Cl2 (5 mL) was added TFA (0.5 mL) dropwise and the reaction mixture was stirred for 18 h. The volatiles were evaporated and the residue was triturated with pentane to give the title compound as colorless gum, which was taken to next step without further purification (200 mg): 1H NMR (300 MHz, DMSO-d6) δ 10.99 (bs, 1H), 8.23 (bs, 2H), 4.62-4.55 (m, 2H), 4.23-4.19 (m, 1H), 1.43 (d, J=8.4 Hz, 3H); ESIMS m/z 186.2 ([M+H]+); IR (thin film) 3445, 2967, 1168 cm−1.
The following molecule was made in accordance with the procedures disclosed in Example 131:
(S)-1-Oxo-1-((2,2,2-trifluoroethyl)amino)butan-2-aminium 2,2,2-trifluoroacetate




The title molecule was isolated as a colorless gum: 1H NMR (300 MHz, DMSO-d6) δ 9.12 (t, J=5.7 Hz, 1H), 8.19 (bs, 2H), 4.14-3.93 (m, 2H), 3.80 (t, J=6.0 Hz, 1H), 1.81-1.71 (m, 2H), 0.88 (t, J=7.2 Hz, 3H); ESIMS m/z 185.00 ([M+H]+); IR (thin film) 3459, 1674, 1169 cm−1.
Example 132
Preparation of 2-Bromo-N—((S)-1-oxo-1-((2,2,2-trifluoroethyl)amino)propan-2-yl)-4-((E)-4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide (F10 and F11)




The title molecule was prepared as described in Example 15. The diastereomeric pairs were separated by chiral HPLC using Chiralpak® IA (4.6×250 mm) 5 m column using 0.1% TFA in hexane and isopropanol as the mobile phase (isocratic 70:30) with a flow rate 1.0 mL/min at ambient temperature. Diastereomer F10 was collected at a retention time of 4.55 min and possessed an optical rotation of [α]D30=+35.6 (c, 0.5% in CH2Cl2). Diastereomer F11 was collected at 8.71 min and possessed an optical rotation of [α]D30=−82.0 (c, 0.5% in CH2Cl2). Characterization data for these molecules are listed in Table 2.
Example 133
Preparation of 2-Bromo-N—((R)-1-oxo-1-((2,2,2-trifluoroethyl)amino)propan-2-yl)-4-((E)-4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide (F12 and F13)




The title molecule was prepared as described in Example 15. The diastereomeric pairs were separated by chiral HPLC using Chiralpak® IA (4.6×250 mm) 5 μm column using 0.1% TFA in hexane and isopropanol as the mobile phase (isocratic 70:30) with a flow rate 1.0 mL/min at ambient temperature. Diastereomer F12 was collected at a retention time of 5.62 min and possessed an optical rotation of [α]D30=+59.4 (c, 1% in CH2Cl2). Diastereomer F13 was collected at 8.85 min and possessed an optical rotation of [α]D30=−44.0 (c, 1% in CH2Cl2). Characterization data for these molecules are listed in Table 2.
The following molecules was prepared in accordance with the procedures disclosed in Example 133:
N—((R)-1-Oxo-1-((2,2,2-trifluoroethyl)amino)propan-2-yl)-4-((E)-4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)-2-(trifluoromethyl)benzamide (F20A and F20B)




Diastereomer F20A (isomer 1) was collected at a retention time of 4.13 min and possessed an optical rotation of [α]D25=+49.2 (c, 1.0% in CH2Cl2). Diastereomer F20B was collected at 4.88 min and possessed an optical rotation of [α]D25=−38.8 (c, 1.0% in CH2Cl2). Characterization data for these molecules are listed in Table 2.
F20A and F20B Stereochemical Assignment F20A and F20B were dissolved in CDCl3 and placed in a 100 μm path length cell with BaF2 windows. IR and vibrational circular dichroism (VCD) spectra were recorded on a IR-2×TM VCD spectrometer (BioTools, Inc.) equipped with dual PEM accessory, with 4 cm−1 resolution. The sample and CDCl3 spectra were acquired for 21 h on an instrument optimized at 1400 cm−1. The solvent-subtracted IR and VCD spectra were collected.
Theoretical Calculations: F20 with R,R- and S,R-configurations were built with Maestro (Schrodinger, LLC. New York, N.Y.). The conformational search was carried out with MacroModel (Schrodinger, LLC. New York, N.Y.) with MMFF94x force field to generate low-energy conformers. Single point calculation (SPE), geometry, frequency, and IR and VCD calculations were performed at the DFT level (B3LYP/lacvp**) in Jaguar (Schrodinger, LLC. New York, N.Y.). A scaling factor of 0.96 was applied to the frequency calculation. Analysis: for F20 with R,R- and S,R-configurations, the top 100 low-energy conformers generated with MacroModel were selected for DFT SPE calculations. These calculations resulted in the 8 and 4 conformers that have energies within 1 kcal/mol higher than the lowest energy conformer for R,R- and S,R-configurations, respectively. The frequency calculations were performed on these conformers to determine the IR and VCD spectra. The Boltzmann-weighted IR and VCD spectra of these conformers were compared with the observed IR and VCD spectra. Based on the overall agreement in VCD pattern between the observed and calculated spectra, the absolute configuration of F20A is assigned as R,R-configuration. The assignment was evaluated by CompareVOA program (BioTools). The confidence level of the assignment is 88% based on a database that includes 105 previous correct assignments for different chiral structures. However, the observed spectrum for F20B does not agree well with the calculated spectrum for S,R-configuration with a confidence level of 65%. But considering that the compound has only one chiral center, two possible configurations and F20A is of R,R-configuration, F20B can be with high confidence assigned as the S,R-configuration.
Example 134
Preparation of (E)-2-Methyl-N-(2-methyl-1-thioxo-1-(2,2,2-trifluoroethylamino)propan-2-yl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzothioamide (F31)




To a stirred solution of (E)-2-methyl-N-(2-methyl-1-oxo-1-(2,2,2-trifluoroethylamino)propan-2-yl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzamide (400 mg, 0.68 mmol) in CH2Cl2 (50 mL) was added P255 (75 mg, 0.34 mmol) and HMDO (0.25 mL, 1.12 mmol) at room temperature and the mixture was refluxed for 3 h. The reaction mixture was cooled to room temperature and another portion of P2S5 (75 mg, 0.34 mmol) was added and the resulting mixture was refluxed for 18 h. The volatiles were evaporated and the residue was purified by prep TLC to give the title compound as pale yellow gum (47 mg, 11%). Characterization data for this molecule is listed in Table 2.
Example 135
Preparation of (E)-2-Bromo-N-(2-methyl-1-oxo-1-((2,2,2-trifluoroethyl)amino)propan-2-yl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide (F1)




To (E)-2-bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzoic acid (200 mg, 0.409 mmol) in MeCN (5 mL) was added 1H-benzo[d][1,2,3]-triazol-1-ol hydrate (63 mg, 0.411 mmol), HBTU (155 mg, 0.409 mmol), N-(2,2,2-trifluoroethyl) 1-amino-2-methyl-propanecarboxamide hydrochloride (180 mg, 0.816 mmol) and diisopropylethylamine (0.24 mL, 1.38 mmol). After 24 h the material was concentrated in vacuo. The crude product was purified by passing the crude reaction mixture through a silica frit and eluting with EtOAc/hexane (1:2). The recovered material was further purified by medium pressure chromatography on silica with EtOAc/hexane as the eluent to afford the title as a white foam (147 mg, 55%). Characterization data for this molecule is listed in Table 2.
Example 136
Preparation of 1-(3,5-Difluoro-4-methoxyphenyl)-2,2,2-trifluoroethanone




Isopropyl magnesium chloride lithium chloride complex (22.0 mL, 28.02 mmol) was added dropwise to a stirred solution of 5-bromo-1,3-difluoro-2-methoxybenzene (5.0 g, 22.42 mmol) at −5° C. in THF (100 mL) and the reaction mixture was stirred at same temperature for 30 min. Methyl trifluoroacetate (3.67 g, 28.69 mmol) was added dropwise and the reaction mixture was stirred at ambient temperature for 2 h. A 2 N HCl solution (200 mL) was added to quench the reaction and then it was extracted with diethylether. The combined organic layers were washed with brine, dried (Na2SO4) filtered and concentrated to afford the title compound (5.4 g, crude) as a yellow liquid. The material was taken to next step without further purification. 1H NMR (400 MHz, CDCl3) δ 7.68-7.60 (m, 2H) 4.19 (s, 3H); ESIMS m/z 240.1 ([M]+).
The following molecule was prepared in accordance with the procedures disclosed in Example 136:
2,6-Difluoro-4-(2,2,2-trifluoroacetyl)benzonitrile




1H NMR (400 MHz, CDCl3) δ 7.45 (d, J=8.4 Hz, 1H), 7.37 (d, J=8.4 Hz, 1H).; EIMS m/z 235.1 ([M]+).
Example 137
Preparation of (E)-N-(1-((2-Fluoroethyl)amino)-1-oxopropan-2-yl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)-2-(trifluoromethyl)benzamide (P1618A)




Step 1: (2R)-tert-Butyl 2-(4-((E)-4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-2-(trifluoromethyl)benzamido)propanoate: The title compound was prepared according to procedures outlined in Example 15: 1HNMR (400 MHz, DMSO d6) δ 8.73 (d, J=6.8 Hz, 1H), 7.92-7.90 (m, 3H), 7.61 (d, J=7.2 Hz, 1H), 7.36 (d, J=7.6 Hz, 1H), 6.99 (dd, J=15.2, 9.2 Hz, 1H), 6.77 (d, J=15.2 Hz, 1H), 4.85-4.80 (m, 1H), 4.30-4.26 (m, 1H), 1.43 (s, 9H), 1.33 (d, J=6.8 Hz, 3H); ESIMS m/z 601.9 ([M−H]−); IR (KBr) 3414, 1732, 1661, 1170, 748 cm−1.
Step 2: (2R)-(4-((E)-4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-2-(trifluoromethyl)benzamido)propanoic acid: TFA (1 mL) was added to a stirred solution of tert-butyl 2-(2-bromo-4-((E)-4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzamido)propanoate (1.0 g, 1.63 mmol) in CH2Cl2 (20 mL) at 0° C. and the reaction mixture was stirred at ambient temperature for 18 h. The volatiles were evaporated under vacuum and the residue was triturated with pentane to afford the title compound as brown solid (0.65 g, 67%): 1HNMR (400 MHz, DMSO-d6) δ 12.60 (bs, 1H), 8.82 (d, J=8.0 Hz, 1H), 7.99 (s, 1H), 7.92-7.89 (m, 3H), 7.51 (d, J=8.0 Hz, 1H), 7.08 (dd, J=15.6, 8.8 Hz, 1H), 6.88 (d, J=15.6 Hz, 1H), 4.88-4.83 (m, 1H), 4.41-4.34 (m, 1H), 1.34 (d, J=7.2 Hz, 3H); ESIMS: m/z 545.7 ([M−H]+); IR (KBr) 3410, 3281, 2928, 1728, 1172, 744 cm−1.
Step 3. (E)-N-(1-((2-Fluoroethyl)amino)-1-oxopropan-2-yl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)-2-(trifluoromethyl)benzamide (P1618: DIPEA (0.60 mL, 1.08 mmol), PyBOP (180 mg, 0.36 mmol) 2-(4-((E)-4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-2-(trifluoromethyl)benzamido)propanoic acid (35 mg, 0.36 mmol) were added to a stirred solution of compound 1 (200 mg, 0.36 mmol) in CH2Cl2 (10 mL) at ambient temperature and the reaction mixture was stirred for 18 h. The reaction mixture was diluted CH2Cl2, washed with 1N HCl, followed by a saturated NaHCO3 solution, water and brine. The organic phase was dried (Na2SO4), filtered, concentrated and the residue was purified by column chromatography on silica (100-200 mesh) eluting with 10% EtOAc in petroleum ether to afford the title compound as a brown solid (85 mg, 39%).
The following molecule was prepared in accordance with the procedures disclosed in Example 137, Step 1:
tert-Butyl 2-(2-bromo-4-((E)-4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzamido)propanoate




1H NMR (400 MHz, DMSO-d6): δ 8.82 (d, J=7.6 Hz, 1H), 7.99 (s, 1H), 7.91-7.90 (m, 3H), 7.50 (d, J=7.6 Hz, 1H), 7.07 (dd, J=16.0, 8.8 Hz, 1H), 6.88 (d, J=15.2 Hz, 1H), 4.88-4.83 (m, 1H), 4.31-4.27 (m, 1H), 1.42 (s, 9H), 1.32 (d, J=7.6 Hz, 3H); ESIMS m/z 611.7 ([M−H]−); IR (KBr) 3296, 2932, 1732, 1162, 743, 556 cm−1.
(E)-tert-Butyl 2-(2-bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzamido)acetate




Isolated as a (620 mg, 72%) pale yellow solid. 1H NMR (400 MHz, DMSO-d6) δ 8.77 (t, J=6.0 Hz, 1H), 7.93-7.91 (m, 3H), 7.62 (d, J=6.8 Hz, 1H), 7.39 (d, J=8.0 Hz, 1H), 7.00 (dd, J=15.6, 9.2 Hz, 1H), 6.77 (d, J=16.0 Hz, 1H), 4.86-4.81 (m, 1H), 3.86-3.85 (m, 2H), 1.33 (s, 9H). ESIMS m/z 599.87 ([M+H]+).
The following molecule was prepared in accordance with the procedures disclosed in Example 137, Step 2:
2-(2-Bromo-4-((E)-4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzamido)propanoic acid




1HNMR (400 MHz, DMSO-d6): δ 12.62 (bs, 1H), 8.73 (d, J=9.6 Hz, 1H), 7.93-7.91 (m, 3H), 7.61 (d, J=8.1 Hz, 1H), 7.37 (d, J=7.8 Hz, 1H), 7.01 (dd, J=15.6, 9.0 Hz, 1H), 6.78 (d, J=15.9 Hz, 1H), 4.89-4.79 (m, 1H), 4.42-4.32 (m, 1H), 1.36 (d, J=7.2 Hz, 3H); ESIMS: m/z 558.0 ([M+H]+); IR (KBr) 3418, 1650, 1115, 747, 560 cm−1.
(E)-2-(2-Bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzamido)acetic acid




Isolated as an (550 mg, 97%) off white solid. 1H NMR (300 MHz, DMSO-d6) δ 12.56 (bs, 1H), 8.73 (t, J=5.4 Hz, 1H), 7.93-7.91 (m, 3H), 7.62 (d, J=9.3 Hz, 1H), 7.40 (d, J=8.1 Hz, 1H), 7.01 (dd, J=15.9, 9.0 Hz, 1H), 6.78 (d, J=15.9 Hz, 1H), 4.89-4.80 (m, 1H), 3.90-3.88 (m, 2H). ESIMS m/z 541.82 ([M−H]−).
Example 138
Preparation of (E)-2-Chloro-5-hydroxy-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide




Step 1. Methyl 4-bromo-2-chloro-5-methoxybenzoate: A 25 mL round bottomed flask equipped with a magnetic stir bar was charged with 4-bromo-2-chloro-5-methoxybenzoic acid (JACS, 1963, 730-2; 1.25 g, 4.72 mmol), 20% MeOH/EtOAc (25 mL) and cooled in an ice-water bath. Trimethylsilyldiazomethane (TMSCHN2 2 M in hexanes, 2.6 mL, 5.20 mmol) was added dropwise via an addition funnel. The reaction continued to stir for 1 h then it was concentrated to afford the title compound as a white solid (1.31 g, 100%): mp 78-79° C.; 1H NMR (400 MHz, CDCl3) δ 7.65 (s, 1H), 7.36 (s, 1H), 3.94 (s, 3H), 3.93 (s, 3H); EIMS m/z 280 ([M]+).

Step 2. 2-Chloro-5-methoxy-4-vinylbenzoic acid: A 25 mL round bottomed flask was charged with methyl 4-bromo-2-chloro-5-methoxybenzoate (640 mg, 2.29 mmol), K2CO3 (665 mg, 4.81 mmol), potassium trifluoro(vinyl)borate (920 mg, 6.87 mmol), PdCl2(dppf) (84 mg, 0.11 mmol) and anhydrous DMSO (15 mL) and stirred at 80° C. for 2 h. The reaction was allowed to cool, water (150 mL) was added and then extracted several times with Et2O. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated to give a brown residue. The crude product was purified via flash chromatography eluting with 15% Et2O/hexanes to give methyl 2-chloro-5-methoxy-4-vinylbenzoate as a yellow oil (440 mg, 85%). To a 25 mL round bottomed flask containing methyl 2-chloro-5-methoxy-4-vinylbenzoate (440 mg, 1.94 mmol) and MeOH (10 mL) was added 1N NaOH (2 mL, 2.04 mmol) and reaction stirred at ambient temperature for 18 h. The reaction mixture was concentrated to give a solid residue. The residue was dissolved in water and extracted 1× with 50% Et2O/hexanes. The aqueous layer was made acidic with 2N HCl and extracted 2× with CH2Cl2, dried over MgSO4, filtered and concentrated to afford the title compound as a white solid (0.39 g, 94%): 1H NMR (400 MHz, CDCl3) δ 7.54 (d, J=0.5 Hz, 1H), 7.52 (s, 1H), 6.98 (ddd, J=17.7, 11.2, 0.6 Hz, 1H), 5.87 (dd, J=17.7, 1.1 Hz, 1H), 5.45 (dd, J=11.2, 1.1 Hz, 1H), 3.90 (s, 3H).
Step 3. (E)-2-Chloro-5-methoxy-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzoic acid: A 50 mL 3 neck round bottomed flask was charged with 2-chloro-5-methoxy-4-vinylbenzoic acid (390 mg, 1.84 mmol)), 5-(1-bromo-2,2,2-trifluoroethyl)-1,2,3-trichlorobenzene (754 mg, 2.20 mmol) and anhydrous N-methylpyrrolidinone (10 mL). Nitrogen was bubbled into the reaction mixture for 15 min. After which time, 2,2′-dipyridyl (57.3 mg, 0.37 mmol) and CuBr (11.7 mg, 0.18 mmol) were added and reaction mixture stirred at 150° C. for 1 h. Reaction mixture was allowed to cool, water (300 mL) was added and extracted several times with Et2O. Organic layer was washed repeatedly with water, dried over MgSO4, filtered and concentrated to afford—the title compound as a light brown foam (870 mg, 100%). This material was 95% pure by LC/MS; ESIMS m/z 473 ([M−H]−). This material was used without further purification.
Step 4. (E)-2-Chloro-5-methoxy-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide: A 50 mL round bottomed flask was charged with (E)-2-chloro-5-methoxy-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzoic acid (780 mg, 1.65 mmol)), di(1H-imidazol-1-yl)methanone (267 mg, 1.65 mmol) and anhydrous THF (30 mL). The resulting mixture was heated at reflux until it ceased giving off gas. 2-Amino-N-(2,2,2-trifluoroethyl)acetamide HCl (257 mg, 1.65 mmol) was added in one portion and the reaction mixture continued to stir at reflux for 18 h. The reaction mixture was concentrated to dryness and the residue was taken up in Et2O (50 mL) and 0.1N HCl (10 mL). The layers were separated. The aqueous layer was extracted 2× with Et2O. The Et2O layers were combined and washed 1× with aqueous NaHCO3, 1× with brine, dried over MgSO4, filtered and concentrated to give a brown oil. The crude product was purified via flash chromatography eluting with 30-40% EtOAc/hexanes to afford the title compound—as an off white foam (280 mg, 28%): 1H NMR (400 MHz, CDCl3) δ 7.45 (s, 1H), 7.41 (s, 2H), 7.29 (s, 1H), 7.28 (s, 1H), 6.84 (m, 2H), 6.43 (dd, J=16.0, 8.3 Hz, 1H), 4.25 (d, J=5.4 Hz, 2H), 4.10 (m, 1H), 3.97 (qd, J=9.0, 6.4 Hz, 2H), 3.87 (s, 3H); ESIMS m/z 613.1 ([M+H]+).
Step 5. (E)-2-Chloro-5-hydroxy-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide: A 25 mL round bottomed flask was charged with (E)-2-chloro-5-methoxy-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide (57 mg, 0.093 mmol) and CH2Cl2 (3 mL). The reaction mixture was cooled to −78° C. and boron tribromide (BBr3, 1.0M solution in CH2Cl2, 0.33 mL, 0.326 mmol) was added slowly via syringe. The reaction allowed to warm to ambient temperature and stirred for 18 h. An additional 0.3-0.4 mL of BBr3 was added at ambient temperature and continued to stir for 3 h. The reaction mixture was added to aqueous NaHCO3 and extracted 3× with CH2Cl2. The CH2Cl2 layers were combined and dried over MgSO4, filtered and concentrated to give an oil. The crude material was purified via flash chromatography eluting with 50% EtOAc/hexanes to afford the title compound as a white solid (18 mg, 33%): mp 190° C. (dec.); 1H NMR (400 MHz, CDCl3) δ 9.81 (s, 1H), 8.06 (d, J=7.0 Hz, 1H), 7.71 (m, 1H), 7.44 (d, J=2.8 Hz, 2H), 7.37 (s, 1H), 7.20 (s, 1H), 6.82 (d, J=15.9 Hz, 1H), 6.50 (m, 1H), 4.14 (m, 3H), 3.89 (m, 2H); ESIMS m/z 599 ([M+H]+).
Example 139
Preparation of 1-(3,4-Dichlorophenyl)-2,2-difluoropropan-1-one 




To a magnetically stirred solution of 4-bromo-1,2-dichlorobenzene (5.64 g, 24.98 mmol) in dry Et2O (109 mL) was added n-BuLi (10.86 mL, 24.98 mmol) via an addition funnel under a nitrogen atmosphere. The reaction mixture was stirred at −78° C. for 30 min., A solution of ethyl 2,2-difluoropropanoate (3.0 g, 21.7 mmol) in Et2O (10 mL) was added dropwise over 15 min and allowed to stir for 1 h. The reaction was then carefully quenched with 1 N HCl (4 mL) and allowed to warm to 23° C. The solution was dilute with Et2O and washed with water. The combined organic layers were dried over Na2SO4, concentrated under reduced pressure and the resulting material was purified via flash column chromatography using 100% hexanes to 5% acetone/95% hexanes as eluent. The relevant fractions were concentrated under reduced pressure to afford the title compound as a colorless oil (3.89 g, 71%): 1H NMR (400 MHz, CDCl3) δ 8.21-8.18 (m, 1H), 7.99-7.93 (m, 1H), 7.59 (dd, J=8.4, 4.2 Hz, 1H), 1.89 (t, J=19.6 Hz, 3H); 19F NMR (376 MHz, CDCl3) δ −92.08-−93.21 (m); EISMS m/z 240 ([M−H]+).
Example 140
(E)-4-(4,4,4-Trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)-2-vinylbenzoic acid




To a stirred solution of (E)-2-bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzoic acid (600 mg, 1.23 mmol) in dry toluene (10 mL) was added tributyl(vinyl)stannane (470 mg, 1.48 mmol) and the mixture was degassed with argon for 15 min Pd(PPh3)4 (72 mg, 0.06 mmol) was added and the reaction mixture was refluxed for 2 h. The reaction mixture was brought to ambient temperature, water was added and the mixture extracted with EtOAc. The organic layer was washed with 2N HCl and brine, dried (Na2SO4), filtered, and concentrated. The residue was purified by column chromatography on silica eluting with 30% EtOAc in petroleum ether to afford the title compound as brown solid (295 mg, 55%): 1H NMR (300 MHz, DMSO-d6) δ 13.05 (bs, 1H), 7.91 (s, 2H), 7.81-7.75 (m, 2H), 7.59 (d, J=8.1 Hz, 1H), 7.48 (dd, J=17.4, 10.8 Hz, 1H), 7.03 (dd, J=15.9, 8.7 Hz, 1H), 6.84 (d, J=15.6 Hz, 1H), 5.88 (d, J=16.5 Hz, 1H), 5.39 (d, J=12.3 Hz, 1H), 4.89-4.82 (m, 1H); ESIMS m/z 432.18 ([M−H]−); IR (thinfilm) 3418, 1689, 1114, 747 cm−1.
Example 141
(E)-2-Iodo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzoic acid




Per Buchwald, et al.; JACS, 2002, 124, 14844-14845, potassium iodide (KI, 273 mg, 1.64 mmol), CuI (31 mg, 0.16 mmol) and trans-N,N′-dimethylcyclohexane-1,2-diamine (catalytic amount) were added to a solution of (E)-2-bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzoic acid (400 mg, 0.82 mmol) in 1,4-dioxane (8 mL). The mixture in an Ace pressure tube was heated at 100° C. for 3 h. The reaction mixture was brought to ambient temperature and filtered through a Celite® pad. The filtrate was concentrated and residue was diluted with EtOAc and washed with 1N HCl followed by brine. The organic layer was dried (Na2SO4), filtered, and concentrated. The residue was purified by column chromatography on silica eluting with 25% EtOAc in petroleum ether to afford the title compound as brown semi solid (240 mg, 55%): 1H NMR (400 MHz, DMSO-d6) δ 13.3 (bs, 1H), 8.21 (s, 1H), 7.91 (s, 2H), 7.71-7.64 (m, 2H), 7.01 (dd, J=15.6, 9.2 Hz, 1H), 6.75 (d, J=15.6 Hz, 1H), 4.85-4.81 (m, 1H); ESIMS m/z 532.8 ([M−H]−); IR (thinfilm) 3436, 1699, 1113, 750 cm−1.
Example 142
Preparation of (E)-2-Bromo-N-(2-methyl-1-(neopentylamino)-1-oxopropan-2-yl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide




Step 1. (E)-2-(2-Bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamido)-2-methylpropanoic acid: A 25 mL round bottomed flask equipped with a magnetic stir bar and reflux condenser was charged with (E)-2-bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzoic acid (400 mg, 0.82 mmol) and 1,2-dichloroethane (DCE) (5 mL). Thionyl chloride (0.12 mL, 1.64 mmol) was added neat in one portion and the resulting reaction mixture was heated at reflux for 2 h. After which time, reaction mixture was allowed to cool and concentrated to give the crude acid chloride which was used without further purification. To a solution containing NaHCO3 (68.8 mg, 0.82 mmol), 2-amino-2-methylpropanoic acid (84 mg, 0.82 mmol) and dodecyltrimethylammonium bromide (2.52 mg, 8.19 μmol) in 10 mL of THF was added to the acid chloride in THF (1 mL). The resulting mixture was heated at reflux for 18 h. Reaction mixture was allowed to cool and added to water, made acidic with 0.1N HCl, extracted (3×) with Et2O, washed (1×) with brine, dried over MgSO4, filtered and evaporated to afford the title compound as a light brown foam (400 mg, 85%): 1H NMR (400 MHz, CDCl3) δ 7.60 (d, J=1.6 Hz, 1H), 7.59 (d, J=8.0 Hz, 1H), 7.40 (s, 2H), 7.37 (dd, J=8.1, 1.6 Hz, 1H), 6.63 (s, 1H), 6.53 (d, J=15.9 Hz, 1H), 6.38 (dd, J=15.9, 7.9 Hz, 1H), 4.10 (p, J=8.3 Hz, 1H), 1.73 (s, 6H). This material is used without further purification.
Step 2. (E)-2-(2-Bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)phenyl)-4,4-dimethyloxazol-5(4H)-one: A 25 mL round bottomed flask was charged with (E)-2-(2-bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamido)-2-methylpropanoic acid (400 mg, 0.70 mmol), CH2Cl2 (10 mL) and stirred at 0° C. EDC.HCl (134 mg, 0.70 mmol) was added in one portion as a solid and the reaction mixture was allowed to warm toward ambient temperature and continued to stir for 1 h. The reaction was diluted with CH2Cl2, washed with brine, dried over MgSO4, filtered and evaporated to give a dark oil. The crude product was purified via flash chromatography eluting with 50% hexanes/CH2Cl2 to afford the title compound as an off white foam (220 mg, 57): 1H NMR (400 MHz, CDCl3) δ 7.76 (d, J=8.1 Hz, 1H), 7.73 (d, J=1.6 Hz, 1H), 7.42 (d, J=7.8 Hz, 3H), 6.56 (d, J=15.9 Hz, 1H), 6.45 (dd, J=15.9, 7.7 Hz, 1H), 4.12 (p, J=8.5 Hz, 1H), 1.57 (s, 6H); 19F NMR (376 MHz, CDCl3) δ −68.55; ESIMS m/z 554 ([M−H]−).
Step 3. (E)-2-Bromo-N-(2-methyl-1-(neopentylamino)-1-oxopropan-2-yl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzamide: A 10 mL round bottomed flask was charged with (E)-2-(2-bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)phenyl)-4,4-dimethyloxazol-5(4H)-one (90 mg, 0.16 mmol) and CH2Cl2 (2 mL). 2,2-Dimethylpropan-1-amine (28.2 mg, 0.324 mmol) was added neat via pipette and the reaction stirred at ambient temperature for 18 h. The reaction mixture was evaporated to give an oil. The crude product was purified via flash chromatography eluting with 20% EtOAc/hexanes to afford the title compound as a white foam (90 mg, 86%): 1H NMR (400 MHz, CDCl3) δ 7.60 (d, J=1.6 Hz, 1H), 7.51 (d, J=8.0 Hz, 1H), 7.40 (s, 2H), 7.36 (dd, J=8.1, 1.6 Hz, 1H), 6.66 (d, J=10.0 Hz, 2H), 6.53 (d, J=15.9 Hz, 1H), 6.38 (dd, J=15.9, 7.8 Hz, 1H), 4.11 (m, 1H), 3.12 (d, J=6.2 Hz, 2H), 1.72 (s, 6H), 0.93 (s, 9H); 19F NMR (376 MHz, CDCl3) δ −68.62; ESIMS m/z 643.19 ([M+H]+).
Example 143
Preparation of 3,5-Dibromo-4-chlorobenzaldehyde 




Step 1. Methyl 4-amino-3,5-dibromobenzoate: conc. H2SO4 (1.35 mL, 25.48 mmol) was added dropwise to a stirred solution of 4-amino-3,5-dibromobenzoic acid (5.0 g, 16.99 mmol) in MeOH (50 mL) at ambient temperature and the reaction mixture was then stirred at 80° C. for 8 h. The reaction mixture was brought to ambient temperature, volatiles were evaporated and ice cold water was added to the residue and which was then extracted with EtOAc. The organic layer was washed with an aqueous NaHCO3 solution followed by brine and water. The solution was then dried (Na2SO4), filtered and concentrated to afford the title compound as an off white solid (5.0 g, 95%): 1H NMR (300 MHz, DMSO-d6) δ 7.91 (s, 2H), 6.20 (bs, 2H), 3.78 (s, 3H); ESIMS m/z 307.0 ([M]+); IR (thin film) 3312, 2953, 1726, 595 cm−1.
Step 2. Methyl 3,5-dibromo-4-chlorobenzoate: CuCl2 (2.82 g, 21.0 mmol) in MeCN (30 mL) was stirred at 80° C. for 30 min. To this mixture tert-butylnitrite (2.7 mL, 23 mmol) was then added dropwise at same temperature and the mixture was stirred for another 10 min. Methyl 4-amino-3,5-dibromobenzoate (5.0 g, 16 mmol) in MeCN (30 mL) was added dropwise to the reaction mixture and then stirred at 80° C. for 30 min. The reaction mixture was brought to ambient temperature and an aqueous ammonia solution (20 mL) was added to the reaction mixture and extracted with petroleum ether. The organic layer was washed with brine followed by water, dried (Na2SO4), filtered and concentrated to afford the title compound as an off white solid (4.5 g, 84%). 1H NMR (300 MHz, DMSO-d6) δ 8.21 (s, 2H), 3.94 (s, 3H); ESIMS m/z 326 ([M]+); IR (thin film) 1732, 746 cm−1.
Step 3. (3,5-Dibromo-4-chlorophenyl)methanol: NaBH4 (1.53 g, 40.65 mmol) was added portionwise to a stirred solution of methyl 3,5-dibromo-4-chlorobenzoate (4.45 g, 13.6 mmol) in MeOH (50 mL) at 0° C. The reaction mixture was then stirred at ambient temperature for 8 h. The volatiles were evaporated and the residue was diluted with CH2Cl2 and washed with brine followed by water. The organic layer was dried (Na2SO4), filtered and concentrated to afford the title compound as an off white solid (3.3 g, 80%): 1H NMR (300 MHz, DMSO-d6) δ 7.71 (s, 2H), 5.49 (bs, 1H), 4.48 (d, J=4.5 Hz, 2H); ESIMS m/z 297.9 ([M]+); IR (thin film) 3460, 747, 534 cm−1.
Step 4. 3,5-Dibromo-4-chlorobenzaldehyde: Pyridinium chlorochormate (PCC, 3.44 g, 15.9 mmol) was added in one portion to a stirred solution of (3,5-dibromo-4-chlorophenyl)methanol (3.2 g, 11.0 mmol) in CHCl3 (40 mL) at ambient temperature and the reaction mixture was stirred overnight. The reaction mixture was filtered through Celite®, the Celite® pad was washed with CHCl3 and the filtrate was concentrated to afford the title compound as an off white solid (2.0 g, 62%): mp 110-113° C.; 1H NMR (300 MHz, DMSO-d6) δ 9.93 (s, 1H), 8.27 (s, 2H); ESIMS m/z 297.0 ([M]+).
Example 144
Preparation of 4-Bromo-3,5-dichlorobenzaldehyde




Step 1. Methyl 4-amino-3,5-dichlorobenzoate: conc. H2SO4 (2.5 mL, 97.04 mmol) was added drop wise to a stirred solution of 4-amino-3,5-dichlorobenzoic acid (10.0 g, 48.54 mmol) in MeOH (150 mL) at 0° C. and the reaction mixture was then stirred at 80° C. for 8 h. The volatiles were evaporated; ice cold water was added to the residue and which was then extracted with EtOAc. The combined organic layers were washed with brine, dried (Na2SO4), filtered and concentrated under reduced pressure to afford the title compound as a white solid (7.5 g, 70%): 1H NMR (300 MHz, DMSO-d6) δ 8.05 (s, 2H), 3.96 (s, 3H); ESIMS m/z 282 ([M]+); IR (KBr): 1733, 762, 514 cm−1.
Step 2. Methyl 4-bromo-3,5-dichlorobenzoate: CuBr2 (7.5 g, 34.08 mmol) in MeCN (50 mL) was stirred at 80° C. for 30 min. To this solution tert-butylnitrite (6.5 mL, 54.55 mmol) was added dropwise at the same temperature and the mixture was stirred for another 10 min. Methyl 4-amino-3,5-dichlorobenzoate in MeCN (30 mL) was added dropwise to the reaction mixture which was then stirred at 80° C. for 30 min. The reaction mixture was brought to ambient temperature. Aqueous ammonia solution (20 mL) was added and extracted with petroleum ether. The organic layer was washed with brine followed by water. The organic solution was dried (Na2SO4), filtered and concentrated to afford the title compound as an off white solid (7.5 g, 77%): 1H NMR (300 MHz, DMSO-d6) δ 8.02 (s, 2H), 3.94 (s, 3H); ESIMS m/z 282 ([M]+); IR (thin film) 1733, 762, 514 cm−1.
Step 3. (4-Bromo-3,5-dichlorophenyl)methanol: DIBAL-H (1M in toluene, 66 mL, and 66.0 mmol) was added dropwise to a stirred solution of methyl 4-bromo-3,5-dichlorobenzoate (7.5 g, 26.0 mmol) in THF (50 mL) at −78° C. The reaction mixture was brought to ambient temperature and stirred for 6 h. The reaction mixture was poured into ice-water and extracted with CH2Cl2. The organic layer was washed with brine followed by water, dried (Na2SO4), filtered and concentrated to afford a mixture of (4-bromo-3,5-dichlorophenyl)methanol and 4-bromo-3,5-dichlorobenzaldehyde (6.0 g) as an off white solid which was taken to next step without purification.
Step 4. 4-Bromo-3,5-dichlorobenzaldehyde: PCC (7.5 g, 35.16 mmol) was added in one portion to a stirred solution containing a mixture of (4-bromo-3,5-dichlorophenyl)methanol and 4-bromo-3,5-dichlorobenzaldehyde (6.0 g) in CHCl3 (40 mL) at ambient temperature and the reaction mixture was stirred overnight. The reaction mixture was filtered through celite. The celite pad was washed with CHCl3. The filtrate was concentrated to afford the title compound as an off white solid (3.5 g, 67%): mp 125-128° C.; 1H NMR (300 MHz, DMSO-d6) δ 9.96 (s, 1H), 8.10 (s, 2H); ESIMS m/z 252 ([M]+).
Example 145
3-Chloro-5-ethylbenzaldehyde




PdCl2(dppf)(37 mg, 0.046 mmol), potassium phosphate (1.93 g, 9.11 mmol) and triethylborane (1M in hexane, 0.45 g, 4.56 mmol) were added to a solution of 3-bromo-5-chloro-benzaldehyde (1.0 g, 4.56 mmol) in THF (20 mL) at ambient temperature and the mixture was refluxed for 12 h. The reaction mixture was brought to ambient temperature, diluted with EtOAc and washed with water. The organic layer was dried (Na2SO4), filtered, concentrated and the residue was purified by column chromatography on silica (100-200 mesh) eluting with 2% EtOAc in petroleum ether to afford the title compound (330 mg, 41%) as a pale yellow liquid: 1H NMR (400 MHz, DMSO-d6) δ 9.97 (s, 1H), 7.75 (d, J=1.6 Hz 1H), 7.73 (s, 1H), 7.65 (s, 1H), 2.74-2.68 (m, 2H), 1.23 (t, J=7.6 Hz, 3H); ESIMS m/z 168.0 ([M]+); IR (thin film) 3071, 1699, 692 cm−1.
Example 146
(E)-2-Amino-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-N-(2-oxo-2-(2,2,2-trifluoroethylamino)ethyl)benzamide




Step 1. (E)-Ethyl 4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-2-nitrobenzoate: 5-(1-Bromo-2,2,2-trifluoroethyl)-1,3-dichloro-2-fluorobenzene (3.5 g, 10.8 mmol), CuCl (54 mg, 0.54 mmol) and 2,2-bipyridyl (169 mg, 1.08 mmol) were added to a stirred solution of ethyl 2-nitro-4-vinylbenzoate (1.2 g, 5.42 mmol) in 1,2-dichlorobenzene (12 mL) at ambient temperature and the mixture was then stirred at 180° C. for 18 h. The reaction mixture was then cooled to ambient temperature, adsorbed on silica gel and purified by column chromatography eluting with 10% EtOAc in petroleum ether to afford the title compound (1.3 g, 53%) as a brown liquid: 1H NMR (DMSO-d6, 300 MHz) δ 8.31 (s, 1H), 8.02-7.95 (m, 1H), 7.88-7.85 (m, 3H), 7.20 (dd, J=15.9, 9.3 Hz, 1H), 6.91 (d, J=15.6 Hz, 1H), 4.91-4.85 (m, 1H), 4.34-4.27 (m, 2H), 1.27 (t, J=6.6 Hz, 3H); ESIMS m/z 463.8 ([M−H]−); IR (KBr) 3439, 2985, 1731, 1251 cm−1.
Step 2. (E)-4-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-2-nitrobenzoic acid: Concentrated HCl (16.0 mL) was added dropwise to a stirred solution of (E)-ethyl 4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-2-nitrobenzoate (800 mg, 1.72 mmol) in 1,4-dioxane (8.0 mL) at 0° C. and the reaction mixture was refluxed for 36 h. The volatiles were evaporated; the residue was diluted with EtOAc and washed with brine and water. The organic layer was dried (Na2SO4), filtered, concentrated and the residue was purified by column chromatography on silica (100-200 mesh) eluting with 30% EtOAc in petroleum ether to afford the title compound as a yellow solid (390 mg, 52%): 1H NMR (400 MHz, DMSO-d6) δ 13.9 (bs, 1H), 8.22 (s, 1H), 7.93-7.91 (m, 1H), 7.86-7.84 (m, 3H), 7.16 (dd, J=15.6, 9.2 Hz, 1H), 6.89 (d, J=15.6 Hz, 1H), 4.89-4.85 (m, 1H). ESIMS m/z 435.9 ([M−H]−); IR (KBr) 3445, 2924, 1708, 1541, 817 cm−1.
Step 3. (E)-4-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-2-nitro-N-(2-oxo-2-(2,2,2-trifluoroethylamino)ethyl)benzamide: 2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride (96 mg, 0.35 mmol), PyBOP (165 mg, 0.32 mmol) and DIPEA (0.1 mL, 0.57 mmol) were added to a stirred solution of (E)-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-2-nitrobenzoic acid (130 mg, 0.29 mmol) in CH2Cl2 (3 mL) and the reaction mixture was stirred at ambient temperature for 8 h. Water was added to reaction mixture and extracted with CH2Cl2. The organic layer was washed with brine, dried (Na2SO4), filtered, concentrated and the residue was purified by column chromatography on silica (100-200 mesh) eluting with 30% EtOAc in petroleum ether to afford the title compound as a yellow solid (120 mg, 74%): 1H NMR (300 MHz, DMSO-d6) δ 9.04 (t, J=5.7 Hz, 1H), 8.60 (t, J=6.0 Hz, 1H), 8.25 (s, 1H), 7.97-7.94 (m, 1H), 7.87 (d, J=6.3 Hz, 2H), 7.69 (d, J=7.5 Hz, 1H), 7.15 (dd, J=15.9, 9.3 Hz, 1H), 6.89 (d, J=15.9 Hz, 1H), 4.88-4.83 (m, 1H), 3.98-3.89 (m, 4H); ESIMS m/z 575.87 ([M+H]+); IR (KBr) 3430, 2925, 1663, 1168, 832 cm−1.
Step 4. (E)-2-Amino-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-N-(2-oxo-2-(2,2,2-trifluoroethylamino)ethyl)benzamide: Iron powder (81.8 mg, 1.46 mmol) and NH4Cl (104 mg, 1.94 mmol) was added to a stirred solution of (E)-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-2-nitro-N-(2-oxo-2-(2,2,2-trifluoroethylamino)ethyl)benzamide (280 mg, 0.486 mmol) in EtOH:water (6 mL, 1:1) at ambient temperature and the mixture was stirred at reflux for 90 min. The reaction mixture was cooled to ambient temperature and filtered through celite. The filtrate was concentrated and the residue was dissolved in EtOAc and washed with saturated NaHCO3 solution, brine and water. The organic layer was dried (Na2SO4), filtered, concentrated and the residue was purified by column chromatography on silica (10-200 mesh) eluting with 35% EtOAc in petroleum ether to afford the titled compound as a yellow solid (215 mg, 81%).
Example 147
(E)-2-Bromo-4-(3-(3,5-dichloro-4-hydroxyphenyl)-4,4,4-trifluorobut-1-enyl)-N-(2-oxo-2-(2,2,2-trifluoroethylamino)ethyl)benzamide




DIPEA (0.20 mL, 1.26 mmol), PyBOP (245 mg, 0.47 mmol) and 2-amino-N-(2,2,2-trifluoroethyl)acetamide (90 mg, 0.47 mmol) were added to a stirred solution of (E)-2-bromo-4-(3-(3,5-dichloro-4-hydroxyphenyl)-4,4,4-trifluorobut-1-enyl)benzoic acid (200 mg, 0.42 mmol, 66% purity) in CH2Cl2 (5 mL) at ambient temperature. The resulting mixture was then stirred for 12 h. The reaction mixture was diluted with CH2Cl2, washed with 1N HCl, followed by saturated sodium bicarbonate solution, brine solution and water. The organic layer was dried (Na2SO4), filtered, concentrated under vacuum. The residue was purified by column chromatography on silica (100-200 mesh) eluting with 30% EtOAc in petroleum ether to give the title compound as light green solid (130 mg, 52%).
Example 148
Preparation of (R)-2-Amino-3-methyl-N-(2,2,2-trifluoroethyl)butanamide




A Parr shaker flask charged with (R)-benzyl (3-methyl-1-oxo-1-((2,2,2-trifluoroethyl)amino)-butan-2-yl)carbamate (4.95 g, 14.9 mmol) in 100 mL of EtOAc and 25 mL of EtOH was treated with 175 mg of 10% Pd/C. The mixture was placed under 40 psi of hydrogen and shaken for 6 h. An additional 65 mg of 10% Pd/C was added to the reaction mixture which was then placed under 40 psi of hydrogen and shaken for 3.5 h. The reaction solution was then filtered through a pad of celite, concentrated in vacuo and purified by sublimation (75 to 85° C., 200-230 millibar) to afford the title compound as a white solid (1.92 g, 65%): mp 43-47° C.; 1H NMR (400 MHz, CDCl3) δ 8.04-7.74 (m, 1H), 3.92 (ddd, J=16.0, 9.3, 6.8 Hz, 1H), 3.84-3.60 (m, 1H), 3.23 (d, J=3.8 Hz, 1H), 2.23 (ddd, J=10.7, 7.0, 3.5 Hz, 1H), 0.92 (d, J=7.0 Hz, 3H), 0.75 (d, J=6.9 Hz, 3H); 19F NMR (376 MHz, CDCl3) δ −72.70.
Example 149
Preparation of (E)-4-(3-(3,5-Dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-2-(methylsulfonyl)-N-(2-oxo-2-(2,2,2-trifluoroethylamino)ethyl)benzamide




Oxone (320 mg, 0.50 mmol) was added to a stirred solution of (E)-4-(3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-1-enyl)-2-(methylthio)-N-(2-oxo-2-(2,2,2-trifluoroethylamino)ethyl)benzamide (150 mg, 0.25 mmol) in acetone-water (10 mL, 1:1) at ambient temperature and the reaction mixture was stirred for 18 h. The reaction mixture was then extracted with CH2Cl2. The organic layer was washed with brine and water, dried (Na2SO4), filtered, concentrated and the residue was triturated with pentane-Et2O (1:1) to afford the title compound as an off white solid (85 mg, 56%): 1H NMR (300 MHz, DMSO-d6) δ 9.01 (t, J=6.0, 1H), 8.37 (t, J=6.4 Hz, 1H), 8.08 (s, 1H), 8.01-7.96 (m, 1H), 7.88-7.86 (m, 2H), 7.64 (d, J=7.6 Hz, 1H), 7.05 (dd, J=16.4, 8.8 Hz, 1H), 6.91 (d, J=15.6 Hz, 1H), 4.87-4.80 (m, 1H), 3.98-3.91 (m, 4H), 3.38 (s, 3H); ESIMS m/z 608.85 ([M+H]+); IR (thin film) 337, 416, 721, 164, 768 cm−1.
The following prophetic molecules could be made in accordance with the procedures disclosed in this application:











Compound



Number
Structure







P1






 


P2






 


P3






 


P4






 


P5






 


P6






 


P7






 


P8






 


P9






 


P10






 


P11






 


P12






 


P13






 


P14






 


P15






 


P16






 


P17






 


P18






 


P19






 


P20






 


P21






 


P22






 


P23






 


P24






 


P25






 


P26






 


P27






 


P28






 


P29






 


P30






 


P31






 


P32






 


P33






 


P34






 


P35






 


P36






 


P37






 


P38






 


P39






 


P40






 


P41






 


P42






 


P43






 


P44






 


P45













The following prophetic molecules could be made in accordance with the procedures disclosed in this application:
















 


















Cmpd













No.
R1
R2
R3
R4
R6
R8
R10
W1
(C1-C8) alkyl
W2
R15





P46
F
F
F
H
CF3
H
Br
O
CH2
O
CH2CF3


P47
F
F
F
H
CF3
H
Cl
O
CH2
O
CH2CF3


P48
F
F
F
H
CF3
H
CF3
O
CH2
O
CH2CF3


P49
F
F
F
H
CF3
H
CH3
O
CH2
O
CH2CF3


P50
F
F
F
H
CF3
H
Br
O
CH2
S
CH2CF3


P51
F
F
F
H
CF3
H
Cl
O
CH2
S
CH2CF3


P52
F
F
F
H
CF3
H
CF3
O
CH2
S
CH2CF3


P53
F
F
F
H
CF3
H
CH3
O
CH2
S
CH2CF3


P54
F
F
F
H
CF3
H
Br
S
CH2
O
CH2CF3


P55
F
F
F
H
CF3
H
Cl
S
CH2
O
CH2CF3


P56
F
F
F
H
CF3
H
CF3
S
CH2
O
CH2CF3


P57
F
F
F
H
CF3
H
CH3
S
CH2
O
CH2CF3


P58
F
F
F
H
CF3
H
Br
O
CH2
O
CH2CHF2


P59
F
F
F
H
CF3
H
Cl
O
CH2
O
CH2CHF2


P60
F
F
F
H
CF3
H
CF3
O
CH2
O
CH2CHF2


P61
F
F
F
H
CF3
H
CH3
O
CH2
O
CH2CHF2


P62
F
F
F
H
CF3
CF3
Br
O
CH2
O
CH2CF3


P63
F
F
F
H
CF3
CF3
Cl
O
CH2
O
CH2CF3


P64
F
F
F
H
CF3
CF3
CF3
O
CH2
O
CH2CF3


P65
F
F
F
H
CF3
CF3
CH3
O
CH2
O
CH2CF3


P66
F
F
F
H
CF2CF3
H
Br
O
CH2
O
CH2CF3


P67
F
F
F
H
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P68
F
F
F
H
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P69
F
F
F
H
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P70
F
F
F
H
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P71
F
F
F
H
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P72
F
F
F
H
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P73
F
F
F
H
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P74
F
F
F
H
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P75
F
F
F
H
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P76
F
F
F
H
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P77
F
F
F
H
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P78
F
F
F
H
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P79
F
F
F
H
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P80
F
F
F
H
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P81
F
F
F
H
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P82
F
F
F
H
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P83
F
F
F
H
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P84
F
F
F
H
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P85
F
F
F
H
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P86
F
F
F
H
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P87
F
F
F
H
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P88
F
F
F
H
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P89
F
F
F
H
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P90
F
F
F
H
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P91
F
F
F
H
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P92
F
F
F
H
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P93
F
F
F
H
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P94
F
F
F
H
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P95
F
F
F
H
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P96
F
F
F
H
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P97
F
F
F
H
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P98
F
F
F
H
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P99
F
F
F
H
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P100
F
F
F
H
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P101
F
F
F
H
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P102
F
F
F
H
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P103
F
F
F
H
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P104
F
F
F
H
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P105
F
F
F
H
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P106
F
F
F
H
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P107
F
F
F
H
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P108
F
F
F
H
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P109
F
F
F
H
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P110
F
F
F
H
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P111
F
F
F
H
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P112
F
F
F
H
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P113
F
F
F
H
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P114
F
F
F
H
CF3
H
Br
O
CH2CH2
O
CH2CF3


P115
F
F
F
H
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P116
F
F
F
H
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P117
F
F
F
H
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P118
Cl
Cl
H
Cl
CF3
H
Br
O
CH2
O
CH2CF3


P119
Cl
Cl
H
Cl
CF3
H
Cl
O
CH2
O
CH2CF3


P120
Cl
Cl
H
Cl
CF3
H
CF3
O
CH2
O
CH2CF3


P121
Cl
Cl
H
Cl
CF3
H
CH3
O
CH2
O
CH2CF3


P122
Cl
Cl
H
Cl
CF3
H
Br
O
CH2
S
CH2CF3


P123
Cl
Cl
H
Cl
CF3
H
Cl
O
CH2
S
CH2CF3


P124
Cl
Cl
H
Cl
CF3
H
CF3
O
CH2
S
CH2CF3


P125
Cl
Cl
H
Cl
CF3
H
CH3
O
CH2
S
CH2CF3


P126
Cl
Cl
H
Cl
CF3
H
Br
S
CH2
O
CH2CF3


P127
Cl
Cl
H
Cl
CF3
H
Cl
S
CH2
O
CH2CF3


P128
Cl
Cl
H
Cl
CF3
H
CF3
S
CH2
O
CH2CF3


P129
Cl
Cl
H
Cl
CF3
H
CH3
S
CH2
O
CH2CF3


P130
Cl
Cl
H
Cl
CF3
H
Br
O
CH2
O
CH2CHF2


P131
Cl
Cl
H
Cl
CF3
H
Cl
O
CH2
O
CH2CHF2


P132
Cl
Cl
H
Cl
CF3
H
CF3
O
CH2
O
CH2CHF2


P133
Cl
Cl
H
Cl
CF3
H
CH3
O
CH2
O
CH2CHF2


P134
Cl
Cl
H
Cl
CF3
CF3
Br
O
CH2
O
CH2CF3


P135
Cl
Cl
H
Cl
CF3
CF3
Cl
O
CH2
O
CH2CF3


P136
Cl
Cl
H
Cl
CF3
CF3
CF3
O
CH2
O
CH2CF3


P137
Cl
Cl
H
Cl
CF3
CF3
CH3
O
CH2
O
CH2CF3


P138
Cl
Cl
H
Cl
CF2CF3
H
Br
O
CH2
O
CH2CF3


P139
Cl
Cl
H
Cl
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P140
Cl
Cl
H
Cl
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P141
Cl
Cl
H
Cl
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P142
Cl
Cl
H
Cl
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P143
Cl
Cl
H
Cl
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P144
Cl
Cl
H
Cl
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P145
Cl
Cl
H
Cl
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P146
Cl
Cl
H
Cl
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P147
Cl
Cl
H
Cl
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P148
Cl
Cl
H
Cl
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P149
Cl
Cl
H
Cl
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P150
Cl
Cl
H
Cl
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P151
Cl
Cl
H
Cl
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P152
Cl
Cl
H
Cl
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P153
Cl
Cl
H
Cl
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P154
Cl
Cl
H
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P155
Cl
Cl
H
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P156
Cl
Cl
H
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P157
Cl
Cl
H
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P158
Cl
Cl
H
Cl
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P159
Cl
Cl
H
Cl
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P160
Cl
Cl
H
Cl
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P161
Cl
Cl
H
Cl
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P162
Cl
Cl
H
Cl
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P163
Cl
Cl
H
Cl
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P164
Cl
Cl
H
Cl
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P165
Cl
Cl
H
Cl
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P166
Cl
Cl
H
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P167
Cl
Cl
H
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P168
Cl
Cl
H
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P169
Cl
Cl
H
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P170
Cl
Cl
H
Cl
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P171
Cl
Cl
H
Cl
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P172
Cl
Cl
H
Cl
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P173
Cl
Cl
H
Cl
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P174
Cl
Cl
H
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P175
Cl
Cl
H
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P176
Cl
Cl
H
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P177
Cl
Cl
H
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P178
Cl
Cl
H
Cl
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P179
Cl
Cl
H
Cl
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P180
Cl
Cl
H
Cl
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P181
Cl
Cl
H
Cl
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P182
Cl
Cl
H
Cl
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P183
Cl
Cl
H
Cl
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P184
Cl
Cl
H
Cl
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P185
Cl
Cl
H
Cl
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P186
Cl
Cl
H
Cl
CF3
H
Br
O
CH2CH2
O
CH2CF3


P187
Cl
Cl
H
Cl
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P188
Cl
Cl
H
Cl
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P189
Cl
Cl
H
Cl
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P190
H
H
H
OCF3
CF3
H
Br
O
CH2
O
CH2CF3


P191
H
H
H
OCF3
CF3
H
Cl
O
CH2
O
CH2CF3


P192
H
H
H
OCF3
CF3
H
CF3
O
CH2
O
CH2CF3


P193
H
H
H
OCF3
CF3
H
CH3
O
CH2
O
CH2CF3


P194
H
H
H
OCF3
CF3
H
Br
O
CH2
S
CH2CF3


P195
H
H
H
OCF3
CF3
H
Cl
O
CH2
S
CH2CF3


P196
H
H
H
OCF3
CF3
H
CF3
O
CH2
S
CH2CF3


P197
H
H
H
OCF3
CF3
H
CH3
O
CH2
S
CH2CF3


P198
H
H
H
OCF3
CF3
H
Br
S
CH2
O
CH2CF3


P199
H
H
H
OCF3
CF3
H
Cl
S
CH2
O
CH2CF3


P200
H
H
H
OCF3
CF3
H
CF3
S
CH2
O
CH2CF3


P201
H
H
H
OCF3
CF3
H
CH3
S
CH2
O
CH2CF3


P202
H
H
H
OCF3
CF3
H
Br
O
CH2
O
CH2CHF2


P203
H
H
H
OCF3
CF3
H
Cl
O
CH2
O
CH2CHF2


P204
H
H
H
OCF3
CF3
H
CF3
O
CH2
O
CH2CHF2


P205
H
H
H
OCF3
CF3
H
CH3
O
CH2
O
CH2CHF2


P206
H
H
H
OCF3
CF3
CF3
Br
O
CH2
O
CH2CF3


P207
H
H
H
OCF3
CF3
CF3
Cl
O
CH2
O
CH2CF3


P208
H
H
H
OCF3
CF3
CF3
CF3
O
CH2
O
CH2CF3


P209
H
H
H
OCF3
CF3
CF3
CH3
O
CH2
O
CH2CF3


P210
H
H
H
OCF3
CF2CF3
H
Br
O
CH2
O
CH2CF3


P211
H
H
H
OCF3
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P212
H
H
H
OCF3
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P213
H
H
H
OCF3
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P214
H
H
H
OCF3
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P215
H
H
H
OCF3
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P216
H
H
H
OCF3
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P217
H
H
H
OCF3
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P218
H
H
H
OCF3
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P219
H
H
H
OCF3
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P220
H
H
H
OCF3
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P221
H
H
H
OCF3
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P222
H
H
H
OCF3
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P223
H
H
H
OCF3
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P224
H
H
H
OCF3
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P225
H
H
H
OCF3
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P226
H
H
H
OCF3
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P227
H
H
H
OCF3
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P228
H
H
H
OCF3
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P229
H
H
H
OCF3
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P230
H
H
H
OCF3
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P231
H
H
H
OCF3
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P232
H
H
H
OCF3
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P233
H
H
H
OCF3
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P234
H
H
H
OCF3
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P235
H
H
H
OCF3
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P236
H
H
H
OCF3
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P237
H
H
H
OCF3
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P238
H
H
H
OCF3
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P239
H
H
H
OCF3
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P240
H
H
H
OCF3
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P241
H
H
H
OCF3
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P242
H
H
H
OCF3
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P243
H
H
H
OCF3
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P244
H
H
H
OCF3
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P245
H
H
H
OCF3
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P246
H
H
H
OCF3
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P247
H
H
H
OCF3
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P248
H
H
H
OCF3
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P249
H
H
H
OCF3
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P250
H
H
H
OCF3
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P251
H
H
H
OCF3
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P252
H
H
H
OCF3
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P253
H
H
H
OCF3
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P254
H
H
H
OCF3
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P255
H
H
H
OCF3
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P256
H
H
H
OCF3
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P257
H
H
H
OCF3
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P258
H
H
H
OCF3
CF3
H
Br
O
CH2CH2
O
CH2CF3


P259
H
H
H
OCF3
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P260
H
H
H
OCF3
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P261
H
H
H
OCF3
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P262
H
F
H
Br
CF3
H
Br
O
CH2
O
CH2CF3


P263
H
F
H
Br
CF3
H
Cl
O
CH2
O
CH2CF3


P264
H
F
H
Br
CF3
H
CF3
O
CH2
O
CH2CF3


P265
H
F
H
Br
CF3
H
CH3
O
CH2
O
CH2CF3


P266
H
F
H
Br
CF3
H
Br
O
CH2
S
CH2CF3


P267
H
F
H
Br
CF3
H
Cl
O
CH2
S
CH2CF3


P268
H
F
H
Br
CF3
H
CF3
O
CH2
S
CH2CF3


P269
H
F
H
Br
CF3
H
CH3
O
CH2
S
CH2CF3


P270
H
F
H
Br
CF3
H
Br
S
CH2
O
CH2CF3


P271
H
F
H
Br
CF3
H
Cl
S
CH2
O
CH2CF3


P272
H
F
H
Br
CF3
H
CF3
S
CH2
O
CH2CF3


P273
H
F
H
Br
CF3
H
CH3
S
CH2
O
CH2CF3


P274
H
F
H
Br
CF3
H
Br
O
CH2
O
CH2CHF2


P275
H
F
H
Br
CF3
H
Cl
O
CH2
O
CH2CHF2


P276
H
F
H
Br
CF3
H
CF3
O
CH2
O
CH2CHF2


P277
H
F
H
Br
CF3
H
CH3
O
CH2
O
CH2CHF2


P278
H
F
H
Br
CF3
CF3
Br
O
CH2
O
CH2CF3


P279
H
F
H
Br
CF3
CF3
Cl
O
CH2
O
CH2CF3


P280
H
F
H
Br
CF3
CF3
CF3
O
CH2
O
CH2CF3


P281
H
F
H
Br
CF3
CF3
CH3
O
CH2
O
CH2CF3


P282
H
F
H
Br
CF2CF3
H
Br
O
CH2
O
CH2CF3


P283
H
F
H
Br
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P284
H
F
H
Br
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P285
H
F
H
Br
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P286
H
F
H
Br
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P287
H
F
H
Br
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P288
H
F
H
Br
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P289
H
F
H
Br
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P290
H
F
H
Br
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P291
H
F
H
Br
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P292
H
F
H
Br
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P293
H
F
H
Br
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P294
H
F
H
Br
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P295
H
F
H
Br
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P296
H
F
H
Br
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P297
H
F
H
Br
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P298
H
F
H
Br
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P299
H
F
H
Br
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P300
H
F
H
Br
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P301
H
F
H
Br
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P302
H
F
H
Br
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P303
H
F
H
Br
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P304
H
F
H
Br
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P305
H
F
H
Br
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P306
H
F
H
Br
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P307
H
F
H
Br
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P308
H
F
H
Br
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P309
H
F
H
Br
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P310
H
F
H
Br
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P311
H
F
H
Br
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P312
H
F
H
Br
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P313
H
F
H
Br
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P314
H
F
H
Br
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P315
H
F
H
Br
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P316
H
F
H
Br
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P317
H
F
H
Br
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P318
H
F
H
Br
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P319
H
F
H
Br
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P320
H
F
H
Br
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P321
H
F
H
Br
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P322
H
F
H
Br
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P323
H
F
H
Br
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P324
H
F
H
Br
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P325
H
F
H
Br
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P326
H
F
H
Br
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P327
H
F
H
Br
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P328
H
F
H
Br
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P329
H
F
H
Br
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P330
H
F
H
Br
CF3
H
Br
O
CH2CH2
O
CH2CF3


P331
H
F
H
Br
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P332
H
F
H
Br
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P333
H
F
H
Br
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P334
H
CH3
Cl
H
CF3
H
Br
O
CH2
O
CH2CF3


P335
H
CH3
Cl
H
CF3
H
Cl
O
CH2
O
CH2CF3


P336
H
CH3
Cl
H
CF3
H
CF3
O
CH2
O
CH2CF3


P337
H
CH3
Cl
H
CF3
H
CH3
O
CH2
O
CH2CF3


P338
H
CH3
Cl
H
CF3
H
Br
O
CH2
S
CH2CF3


P339
H
CH3
Cl
H
CF3
H
Cl
O
CH2
S
CH2CF3


P340
H
CH3
Cl
H
CF3
H
CF3
O
CH2
S
CH2CF3


P341
H
CH3
Cl
H
CF3
H
CH3
O
CH2
S
CH2CF3


P342
H
CH3
Cl
H
CF3
H
Br
S
CH2
O
CH2CF3


P343
H
CH3
Cl
H
CF3
H
Cl
S
CH2
O
CH2CF3


P344
H
CH3
Cl
H
CF3
H
CF3
S
CH2
O
CH2CF3


P345
H
CH3
Cl
H
CF3
H
CH3
S
CH2
O
CH2CF3


P346
H
CH3
Cl
H
CF3
H
Br
O
CH2
O
CH2CHF2


P347
H
CH3
Cl
H
CF3
H
Cl
O
CH2
O
CH2CHF2


P348
H
CH3
Cl
H
CF3
H
CF3
O
CH2
O
CH2CHF2


P349
H
CH3
Cl
H
CF3
H
CH3
O
CH2
O
CH2CHF2


P350
H
CH3
Cl
H
CF3
CF3
Br
O
CH2
O
CH2CF3


P351
H
CH3
Cl
H
CF3
CF3
Cl
O
CH2
O
CH2CF3


P352
H
CH3
Cl
H
CF3
CF3
CF3
O
CH2
O
CH2CF3


P353
H
CH3
Cl
H
CF3
CF3
CH3
O
CH2
O
CH2CF3


P354
H
CH3
Cl
H
CF2CF3
H
Br
O
CH2
O
CH2CF3


P355
H
CH3
Cl
H
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P356
H
CH3
Cl
H
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P357
H
CH3
Cl
H
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P358
H
CH3
Cl
H
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P359
H
CH3
Cl
H
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P360
H
CH3
Cl
H
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P361
H
CH3
Cl
H
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P362
H
CH3
Cl
H
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P363
H
CH3
Cl
H
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P364
H
CH3
Cl
H
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P365
H
CH3
Cl
H
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P366
H
CH3
Cl
H
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P367
H
CH3
Cl
H
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P368
H
CH3
Cl
H
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P369
H
CH3
Cl
H
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P370
H
CH3
Cl
H
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P371
H
CH3
Cl
H
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P372
H
CH3
Cl
H
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P373
H
CH3
Cl
H
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P374
H
CH3
Cl
H
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P375
H
CH3
Cl
H
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P376
H
CH3
Cl
H
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P377
H
CH3
Cl
H
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P378
H
CH3
Cl
H
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P379
H
CH3
Cl
H
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P380
H
CH3
Cl
H
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P381
H
CH3
Cl
H
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P382
H
CH3
Cl
H
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P383
H
CH3
Cl
H
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P384
H
CH3
Cl
H
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P385
H
CH3
Cl
H
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P386
H
CH3
Cl
H
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P387
H
CH3
Cl
H
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P388
H
CH3
Cl
H
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P389
H
CH3
Cl
H
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P390
H
CH3
Cl
H
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P391
H
CH3
Cl
H
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P392
H
CH3
Cl
H
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P393
H
CH3
Cl
H
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P394
H
CH3
Cl
H
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P395
H
CH3
Cl
H
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P396
H
CH3
Cl
H
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P397
H
CH3
Cl
H
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P398
H
CH3
Cl
H
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P399
H
CH3
Cl
H
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P400
H
CH3
Cl
H
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P401
H
CH3
Cl
H
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P402
H
CH3
Cl
H
CF3
H
Br
O
CH2CH2
O
CH2CF3


P403
H
CH3
Cl
H
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P404
H
CH3
Cl
H
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P405
H
CH3
Cl
H
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P406
H
Cl
CH3
H
CF3
H
Br
O
CH2
O
CH2CF3


P407
H
Cl
CH3
H
CF3
H
Cl
O
CH2
O
CH2CF3


P408
H
Cl
CH3
H
CF3
H
CF3
O
CH2
O
CH2CF3


P409
H
Cl
CH3
H
CF3
H
CH3
O
CH2
O
CH2CF3


P410
H
Cl
CH3
H
CF3
H
Br
O
CH2
S
CH2CF3


P411
H
Cl
CH3
H
CF3
H
Cl
O
CH2
S
CH2CF3


P412
H
Cl
CH3
H
CF3
H
CF3
O
CH2
S
CH2CF3


P413
H
Cl
CH3
H
CF3
H
CH3
O
CH2
S
CH2CF3


P414
H
Cl
CH3
H
CF3
H
Br
S
CH2
O
CH2CF3


P415
H
Cl
CH3
H
CF3
H
Cl
S
CH2
O
CH2CF3


P416
H
Cl
CH3
H
CF3
H
CF3
S
CH2
O
CH2CF3


P417
H
Cl
CH3
H
CF3
H
CH3
S
CH2
O
CH2CF3


P418
H
Cl
CH3
H
CF3
H
Br
O
CH2
O
CH2CHF2


P419
H
Cl
CH3
H
CF3
H
Cl
O
CH2
O
CH2CHF2


P420
H
Cl
CH3
H
CF3
H
CF3
O
CH2
O
CH2CHF2


P421
H
Cl
CH3
H
CF3
H
CH3
O
CH2
O
CH2CHF2


P422
H
Cl
CH3
H
CF3
CF3
Br
O
CH2
O
CH2CF3


P423
H
Cl
CH3
H
CF3
CF3
Cl
O
CH2
O
CH2CF3


P424
H
Cl
CH3
H
CF3
CF3
CF3
O
CH2
O
CH2CF3


P425
H
Cl
CH3
H
CF3
CF3
CH3
O
CH2
O
CH2CF3


P426
H
Cl
CH3
H
CF2CF3
H
Br
O
CH2
O
CH2CF3


P427
H
Cl
CH3
H
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P428
H
Cl
CH3
H
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P429
H
Cl
CH3
H
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P430
H
Cl
CH3
H
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P431
H
Cl
CH3
H
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P432
H
Cl
CH3
H
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P433
H
Cl
CH3
H
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P434
H
Cl
CH3
H
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P435
H
Cl
CH3
H
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P436
H
Cl
CH3
H
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P437
H
Cl
CH3
H
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P438
H
Cl
CH3
H
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P439
H
Cl
CH3
H
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P440
H
Cl
CH3
H
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P441
H
Cl
CH3
H
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P442
H
Cl
CH3
H
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P443
H
Cl
CH3
H
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P444
H
Cl
CH3
H
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P445
H
Cl
CH3
H
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P446
H
Cl
CH3
H
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P447
H
Cl
CH3
H
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P448
H
Cl
CH3
H
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P449
H
Cl
CH3
H
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P450
H
Cl
CH3
H
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P451
H
Cl
CH3
H
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P452
H
Cl
CH3
H
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P453
H
Cl
CH3
H
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P454
H
Cl
CH3
H
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P455
H
Cl
CH3
H
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P456
H
Cl
CH3
H
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P457
H
Cl
CH3
H
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P458
H
Cl
CH3
H
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P459
H
Cl
CH3
H
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P460
H
Cl
CH3
H
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P461
H
Cl
CH3
H
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P462
H
Cl
CH3
H
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P463
H
Cl
CH3
H
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P464
H
Cl
CH3
H
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P465
H
Cl
CH3
H
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P466
H
Cl
CH3
H
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P467
H
Cl
CH3
H
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P468
H
Cl
CH3
H
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P469
H
Cl
CH3
H
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P470
H
Cl
CH3
H
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P471
H
Cl
CH3
H
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P472
H
Cl
CH3
H
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P473
H
Cl
CH3
H
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P474
H
Cl
CH3
H
CF3
H
Br
O
CH2CH2
O
CH2CF3


P475
H
Cl
CH3
H
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P476
H
Cl
CH3
H
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P477
H
Cl
CH3
H
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P478
H
CH3
F
CH3
CF3
H
Br
O
CH2
O
CH2CF3


P479
H
CH3
F
CH3
CF3
H
Cl
O
CH2
O
CH2CF3


P480
H
CH3
F
CH3
CF3
H
CF3
O
CH2
O
CH2CF3


P481
H
CH3
F
CH3
CF3
H
CH3
O
CH2
O
CH2CF3


P482
H
CH3
F
CH3
CF3
H
Br
O
CH2
S
CH2CF3


P483
H
CH3
F
CH3
CF3
H
Cl
O
CH2
S
CH2CF3


P484
H
CH3
F
CH3
CF3
H
CF3
O
CH2
S
CH2CF3


P485
H
CH3
F
CH3
CF3
H
CH3
O
CH2
S
CH2CF3


P486
H
CH3
F
CH3
CF3
H
Br
S
CH2
O
CH2CF3


P487
H
CH3
F
CH3
CF3
H
Cl
S
CH2
O
CH2CF3


P488
H
CH3
F
CH3
CF3
H
CF3
S
CH2
O
CH2CF3


P489
H
CH3
F
CH3
CF3
H
CH3
S
CH2
O
CH2CF3


P490
H
CH3
F
CH3
CF3
H
Br
O
CH2
O
CH2CHF2


P491
H
CH3
F
CH3
CF3
H
Cl
O
CH2
O
CH2CHF2


P492
H
CH3
F
CH3
CF3
H
CF3
O
CH2
O
CH2CHF2


P493
H
CH3
F
CH3
CF3
H
CH3
O
CH2
O
CH2CHF2


P494
H
CH3
F
CH3
CF3
CF3
Br
O
CH2
O
CH2CF3


P495
H
CH3
F
CH3
CF3
CF3
Cl
O
CH2
O
CH2CF3


P496
H
CH3
F
CH3
CF3
CF3
CF3
O
CH2
O
CH2CF3


P497
H
CH3
F
CH3
CF3
CF3
CH3
O
CH2
O
CH2CF3


P498
H
CH3
F
CH3
CF2CF3
H
Br
O
CH2
O
CH2CF3


P499
H
CH3
F
CH3
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P500
H
CH3
F
CH3
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P501
H
CH3
F
CH3
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P502
H
CH3
F
CH3
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P503
H
CH3
F
CH3
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P504
H
CH3
F
CH3
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P505
H
CH3
F
CH3
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P506
H
CH3
F
CH3
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P507
H
CH3
F
CH3
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P508
H
CH3
F
CH3
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P509
H
CH3
F
CH3
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P510
H
CH3
F
CH3
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P511
H
CH3
F
CH3
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P512
H
CH3
F
CH3
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P513
H
CH3
F
CH3
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P514
H
CH3
F
CH3
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P515
H
CH3
F
CH3
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P516
H
CH3
F
CH3
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P517
H
CH3
F
CH3
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P518
H
CH3
F
CH3
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P519
H
CH3
F
CH3
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P520
H
CH3
F
CH3
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P521
H
CH3
F
CH3
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P522
H
CH3
F
CH3
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P523
H
CH3
F
CH3
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P524
H
CH3
F
CH3
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P525
H
CH3
F
CH3
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P526
H
CH3
F
CH3
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P527
H
CH3
F
CH3
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P528
H
CH3
F
CH3
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P529
H
CH3
F
CH3
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P530
H
CH3
F
CH3
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P531
H
CH3
F
CH3
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P532
H
CH3
F
CH3
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P533
H
CH3
F
CH3
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P534
H
CH3
F
CH3
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P535
H
CH3
F
CH3
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P536
H
CH3
F
CH3
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P537
H
CH3
F
CH3
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P538
H
CH3
F
CH3
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P539
H
CH3
F
CH3
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P540
H
CH3
F
CH3
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P541
H
CH3
F
CH3
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P542
H
CH3
F
CH3
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P543
H
CH3
F
CH3
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P544
H
CH3
F
CH3
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P545
H
CH3
F
CH3
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P546
H
CH3
F
CH3
CF3
H
Br
O
CH2CH2
O
CH2CF3


P547
H
CH3
F
CH3
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P548
H
CH3
F
CH3
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P549
H
CH3
F
CH3
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P550
H
Cl
H
Br
CF3
H
Br
O
CH2
O
CH2CF3


P551
H
Cl
H
Br
CF3
H
Cl
O
CH2
O
CH2CF3


P552
H
Cl
H
Br
CF3
H
CF3
O
CH2
O
CH2CF3


P553
H
Cl
H
Br
CF3
H
CH3
O
CH2
O
CH2CF3


P554
H
Cl
H
Br
CF3
H
Br
O
CH2
S
CH2CF3


P555
H
Cl
H
Br
CF3
H
Cl
O
CH2
S
CH2CF3


P556
H
Cl
H
Br
CF3
H
CF3
O
CH2
S
CH2CF3


P557
H
Cl
H
Br
CF3
H
CH3
O
CH2
S
CH2CF3


P558
H
Cl
H
Br
CF3
H
Br
S
CH2
O
CH2CF3


P559
H
Cl
H
Br
CF3
H
Cl
S
CH2
O
CH2CF3


P560
H
Cl
H
Br
CF3
H
CF3
S
CH2
O
CH2CF3


P561
H
Cl
H
Br
CF3
H
CH3
S
CH2
O
CH2CF3


P562
H
Cl
H
Br
CF3
H
Br
O
CH2
O
CH2CHF2


P563
H
Cl
H
Br
CF3
H
Cl
O
CH2
O
CH2CHF2


P564
H
Cl
H
Br
CF3
H
CF3
O
CH2
O
CH2CHF2


P565
H
Cl
H
Br
CF3
H
CH3
O
CH2
O
CH2CHF2


P566
H
Cl
H
Br
CF3
CF3
Br
O
CH2
O
CH2CF3


P567
H
Cl
H
Br
CF3
CF3
Cl
O
CH2
O
CH2CF3


P568
H
Cl
H
Br
CF3
CF3
CF3
O
CH2
O
CH2CF3


P569
H
Cl
H
Br
CF3
CF3
CH3
O
CH2
O
CH2CF3


P570
H
Cl
H
Br
CF2CF3
H
Br
O
CH2
O
CH2CF3


P571
H
Cl
H
Br
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P572
H
Cl
H
Br
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P573
H
Cl
H
Br
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P574
H
Cl
H
Br
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P575
H
Cl
H
Br
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P576
H
Cl
H
Br
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P577
H
Cl
H
Br
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P578
H
Cl
H
Br
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P579
H
Cl
H
Br
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P580
H
Cl
H
Br
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P581
H
Cl
H
Br
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P582
H
Cl
H
Br
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P583
H
Cl
H
Br
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P584
H
Cl
H
Br
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P585
H
Cl
H
Br
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P586
H
Cl
H
Br
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P587
H
Cl
H
Br
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P588
H
Cl
H
Br
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P589
H
Cl
H
Br
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P590
H
Cl
H
Br
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P591
H
Cl
H
Br
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P592
H
Cl
H
Br
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P593
H
Cl
H
Br
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P594
H
Cl
H
Br
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P595
H
Cl
H
Br
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P596
H
Cl
H
Br
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P597
H
Cl
H
Br
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P598
H
Cl
H
Br
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P599
H
Cl
H
Br
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P600
H
Cl
H
Br
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P601
H
Cl
H
Br
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P602
H
Cl
H
Br
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P603
H
Cl
H
Br
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P604
H
Cl
H
Br
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P605
H
Cl
H
Br
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P606
H
Cl
H
Br
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P607
H
Cl
H
Br
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P608
H
Cl
H
Br
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P609
H
Cl
H
Br
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P610
H
Cl
H
Br
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P611
H
Cl
H
Br
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P612
H
Cl
H
Br
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P613
H
Cl
H
Br
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P614
H
Cl
H
Br
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P615
H
Cl
H
Br
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P616
H
Cl
H
Br
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P617
H
Cl
H
Br
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P618
H
Cl
H
Br
CF3
H
Br
O
CH2CH2
O
CH2CF3


P619
H
Cl
H
Br
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P620
H
Cl
H
Br
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P621
H
Cl
H
Br
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P622
H
H
Br
Br
CF3
H
Br
O
CH2
O
CH2CF3


P623
H
H
Br
Br
CF3
H
Cl
O
CH2
O
CH2CF3


P624
H
H
Br
Br
CF3
H
CF3
O
CH2
O
CH2CF3


P625
H
H
Br
Br
CF3
H
CH3
O
CH2
O
CH2CF3


P626
H
H
Br
Br
CF3
H
Br
O
CH2
S
CH2CF3


P627
H
H
Br
Br
CF3
H
Cl
O
CH2
S
CH2CF3


P628
H
H
Br
Br
CF3
H
CF3
O
CH2
S
CH2CF3


P629
H
H
Br
Br
CF3
H
CH3
O
CH2
S
CH2CF3


P630
H
H
Br
Br
CF3
H
Br
S
CH2
O
CH2CF3


P631
H
H
Br
Br
CF3
H
Cl
S
CH2
O
CH2CF3


P632
H
H
Br
Br
CF3
H
CF3
S
CH2
O
CH2CF3


P633
H
H
Br
Br
CF3
H
CH3
S
CH2
O
CH2CF3


P634
H
H
Br
Br
CF3
H
Br
O
CH2
O
CH2CHF2


P635
H
H
Br
Br
CF3
H
Cl
O
CH2
O
CH2CHF2


P636
H
H
Br
Br
CF3
H
CF3
O
CH2
O
CH2CHF2


P637
H
H
Br
Br
CF3
H
CH3
O
CH2
O
CH2CHF2


P638
H
H
Br
Br
CF3
CF3
Br
O
CH2
O
CH2CF3


P639
H
H
Br
Br
CF3
CF3
Cl
O
CH2
O
CH2CF3


P640
H
H
Br
Br
CF3
CF3
CF3
O
CH2
O
CH2CF3


P641
H
H
Br
Br
CF3
CF3
CH3
O
CH2
O
CH2CF3


P642
H
H
Br
Br
CF2CF3
H
Br
O
CH2
O
CH2CF3


P643
H
H
Br
Br
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P644
H
H
Br
Br
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P645
H
H
Br
Br
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P646
H
H
Br
Br
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P647
H
H
Br
Br
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P648
H
H
Br
Br
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P649
H
H
Br
Br
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P650
H
H
Br
Br
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P651
H
H
Br
Br
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P652
H
H
Br
Br
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P653
H
H
Br
Br
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P654
H
H
Br
Br
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P655
H
H
Br
Br
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P656
H
H
Br
Br
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P657
H
H
Br
Br
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P658
H
H
Br
Br
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P659
H
H
Br
Br
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P660
H
H
Br
Br
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P661
H
H
Br
Br
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P662
H
H
Br
Br
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P663
H
H
Br
Br
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P664
H
H
Br
Br
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P665
H
H
Br
Br
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P666
H
H
Br
Br
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P667
H
H
Br
Br
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P668
H
H
Br
Br
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P669
H
H
Br
Br
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P670
H
H
Br
Br
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P671
H
H
Br
Br
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P672
H
H
Br
Br
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P673
H
H
Br
Br
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P674
H
H
Br
Br
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P675
H
H
Br
Br
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P676
H
H
Br
Br
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P677
H
H
Br
Br
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P678
H
H
Br
Br
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P679
H
H
Br
Br
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P680
H
H
Br
Br
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P681
H
H
Br
Br
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P682
H
H
Br
Br
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P683
H
H
Br
Br
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P684
H
H
Br
Br
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P685
H
H
Br
Br
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P686
H
H
Br
Br
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P687
H
H
Br
Br
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P688
H
H
Br
Br
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P689
H
H
Br
Br
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P690
H
H
Br
Br
CF3
H
Br
O
CH2CH2
O
CH2CF3


P691
H
H
Br
Br
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P692
H
H
Br
Br
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P693
H
H
Br
Br
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P694
H
H
Cl
NO2
CF3
H
Br
O
CH2
O
CH2CF3


P695
H
H
Cl
NO2
CF3
H
Cl
O
CH2
O
CH2CF3


P696
H
H
Cl
NO2
CF3
H
CF3
O
CH2
O
CH2CF3


P697
H
H
Cl
NO2
CF3
H
CH3
O
CH2
O
CH2CF3


P698
H
H
Cl
NO2
CF3
H
Br
O
CH2
S
CH2CF3


P699
H
H
Cl
NO2
CF3
H
Cl
O
CH2
S
CH2CF3


P700
H
H
Cl
NO2
CF3
H
CF3
O
CH2
S
CH2CF3


P701
H
H
Cl
NO2
CF3
H
CH3
O
CH2
S
CH2CF3


P702
H
H
Cl
NO2
CF3
H
Br
S
CH2
O
CH2CF3


P703
H
H
Cl
NO2
CF3
H
Cl
S
CH2
O
CH2CF3


P704
H
H
Cl
NO2
CF3
H
CF3
S
CH2
O
CH2CF3


P705
H
H
Cl
NO2
CF3
H
CH3
S
CH2
O
CH2CF3


P706
H
H
Cl
NO2
CF3
H
Br
O
CH2
O
CH2CHF2


P707
H
H
Cl
NO2
CF3
H
Cl
O
CH2
O
CH2CHF2


P708
H
H
Cl
NO2
CF3
H
CF3
O
CH2
O
CH2CHF2


P709
H
H
Cl
NO2
CF3
H
CH3
O
CH2
O
CH2CHF2


P710
H
H
Cl
NO2
CF3
CF3
Br
O
CH2
O
CH2CF3


P711
H
H
Cl
NO2
CF3
CF3
Cl
O
CH2
O
CH2CF3


P712
H
H
Cl
NO2
CF3
CF3
CF3
O
CH2
O
CH2CF3


P713
H
H
Cl
NO2
CF3
CF3
CH3
O
CH2
O
CH2CF3


P714
H
H
Cl
NO2
CF2CF3
H
Br
O
CH2
O
CH2CF3


P715
H
H
Cl
NO2
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P716
H
H
Cl
NO2
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P717
H
H
Cl
NO2
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P718
H
H
Cl
NO2
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P719
H
H
Cl
NO2
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P720
H
H
Cl
NO2
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P721
H
H
Cl
NO2
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P722
H
H
Cl
NO2
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P723
H
H
Cl
NO2
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P724
H
H
Cl
NO2
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P725
H
H
Cl
NO2
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P726
H
H
Cl
NO2
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P727
H
H
Cl
NO2
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P728
H
H
Cl
NO2
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P729
H
H
Cl
NO2
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P730
H
H
Cl
NO2
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P731
H
H
Cl
NO2
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P732
H
H
Cl
NO2
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P733
H
H
Cl
NO2
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P734
H
H
Cl
NO2
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P735
H
H
Cl
NO2
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P736
H
H
Cl
NO2
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P737
H
H
Cl
NO2
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P738
H
H
Cl
NO2
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P739
H
H
Cl
NO2
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P740
H
H
Cl
NO2
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P741
H
H
Cl
NO2
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P742
H
H
Cl
NO2
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P743
H
H
Cl
NO2
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P744
H
H
Cl
NO2
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P745
H
H
Cl
NO2
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P746
H
H
Cl
NO2
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P747
H
H
Cl
NO2
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P748
H
H
Cl
NO2
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P749
H
H
Cl
NO2
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P750
H
H
Cl
NO2
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P751
H
H
Cl
NO2
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P752
H
H
Cl
NO2
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P753
H
H
Cl
NO2
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P754
H
H
Cl
NO2
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P755
H
H
Cl
NO2
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P756
H
H
Cl
NO2
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P757
H
H
Cl
NO2
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P758
H
H
Cl
NO2
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P759
H
H
Cl
NO2
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P760
H
H
Cl
NO2
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P761
H
H
Cl
NO2
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P762
H
H
Cl
NO2
CF3
H
Br
O
CH2CH2
O
CH2CF3


P763
H
H
Cl
NO2
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P764
H
H
Cl
NO2
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P765
H
H
Cl
NO2
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P766
H
H
F
CN
CF3
H
Br
O
CH2
O
CH2CF3


P767
H
H
F
CN
CF3
H
Cl
O
CH2
O
CH2CF3


P768
H
H
F
CN
CF3
H
CF3
O
CH2
O
CH2CF3


P769
H
H
F
CN
CF3
H
CH3
O
CH2
O
CH2CF3


P770
H
H
F
CN
CF3
H
Br
O
CH2
S
CH2CF3


P771
H
H
F
CN
CF3
H
Cl
O
CH2
S
CH2CF3


P772
H
H
F
CN
CF3
H
CF3
O
CH2
S
CH2CF3


P773
H
H
F
CN
CF3
H
CH3
O
CH2
S
CH2CF3


P774
H
H
F
CN
CF3
H
Br
S
CH2
O
CH2CF3


P775
H
H
F
CN
CF3
H
Cl
S
CH2
O
CH2CF3


P776
H
H
F
CN
CF3
H
CF3
S
CH2
O
CH2CF3


P777
H
H
F
CN
CF3
H
CH3
S
CH2
O
CH2CF3


P778
H
H
F
CN
CF3
H
Br
O
CH2
O
CH2CHF2


P779
H
H
F
CN
CF3
H
Cl
O
CH2
O
CH2CHF2


P780
H
H
F
CN
CF3
H
CF3
O
CH2
O
CH2CHF2


P781
H
H
F
CN
CF3
H
CH3
O
CH2
O
CH2CHF2


P782
H
H
F
CN
CF3
CF3
Br
O
CH2
O
CH2CF3


P783
H
H
F
CN
CF3
CF3
Cl
O
CH2
O
CH2CF3


P784
H
H
F
CN
CF3
CF3
CF3
O
CH2
O
CH2CF3


P785
H
H
F
CN
CF3
CF3
CH3
O
CH2
O
CH2CF3


P786
H
H
F
CN
CF2CF3
H
Br
O
CH2
O
CH2CF3


P787
H
H
F
CN
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P788
H
H
F
CN
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P789
H
H
F
CN
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P790
H
H
F
CN
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P791
H
H
F
CN
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P792
H
H
F
CN
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P793
H
H
F
CN
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P794
H
H
F
CN
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P795
H
H
F
CN
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P796
H
H
F
CN
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P797
H
H
F
CN
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P798
H
H
F
CN
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P799
H
H
F
CN
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P800
H
H
F
CN
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P801
H
H
F
CN
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P802
H
H
F
CN
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P803
H
H
F
CN
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P804
H
H
F
CN
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P805
H
H
F
CN
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P806
H
H
F
CN
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P807
H
H
F
CN
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P808
H
H
F
CN
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P809
H
H
F
CN
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P810
H
H
F
CN
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P811
H
H
F
CN
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P812
H
H
F
CN
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P813
H
H
F
CN
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P814
H
H
F
CN
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P815
H
H
F
CN
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P816
H
H
F
CN
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P817
H
H
F
CN
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P818
H
H
F
CN
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P819
H
H
F
CN
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P820
H
H
F
CN
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P821
H
H
F
CN
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P822
H
H
F
CN
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P823
H
H
F
CN
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P824
H
H
F
CN
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P825
H
H
F
CN
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P826
H
H
F
CN
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P827
H
H
F
CN
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P828
H
H
F
CN
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P829
H
H
F
CN
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P830
H
H
F
CN
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P831
H
H
F
CN
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P832
H
H
F
CN
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P833
H
H
F
CN
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P834
H
H
F
CN
CF3
H
Br
O
CH2CH2
O
CH2CF3


P835
H
H
F
CN
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P836
H
H
F
CN
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P837
H
H
F
CN
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P838
H
Cl
OCF3
Cl
CF3
H
Br
O
CH2
O
CH2CF3


P839
H
Cl
OCF3
Cl
CF3
H
Cl
O
CH2
O
CH2CF3


P840
H
Cl
OCF3
Cl
CF3
H
CF3
O
CH2
O
CH2CF3


P841
H
Cl
OCF3
Cl
CF3
H
CH3
O
CH2
O
CH2CF3


P842
H
Cl
OCF3
Cl
CF3
H
Br
O
CH2
S
CH2CF3


P843
H
Cl
OCF3
Cl
CF3
H
Cl
O
CH2
S
CH2CF3


P844
H
Cl
OCF3
Cl
CF3
H
CF3
O
CH2
S
CH2CF3


P845
H
Cl
OCF3
Cl
CF3
H
CH3
O
CH2
S
CH2CF3


P846
H
Cl
OCF3
Cl
CF3
H
Br
S
CH2
O
CH2CF3


P847
H
Cl
OCF3
Cl
CF3
H
Cl
S
CH2
O
CH2CF3


P848
H
Cl
OCF3
Cl
CF3
H
CF3
S
CH2
O
CH2CF3


P849
H
Cl
OCF3
Cl
CF3
H
CH3
S
CH2
O
CH2CF3


P850
H
Cl
OCF3
Cl
CF3
H
Br
O
CH2
O
CH2CHF2


P851
H
Cl
OCF3
Cl
CF3
H
Cl
O
CH2
O
CH2CHF2


P852
H
Cl
OCF3
Cl
CF3
H
CF3
O
CH2
O
CH2CHF2


P853
H
Cl
OCF3
Cl
CF3
H
CH3
O
CH2
O
CH2CHF2


P854
H
Cl
OCF3
Cl
CF3
CF3
Br
O
CH2
O
CH2CF3


P855
H
Cl
OCF3
Cl
CF3
CF3
Cl
O
CH2
O
CH2CF3


P856
H
Cl
OCF3
Cl
CF3
CF3
CF3
O
CH2
O
CH2CF3


P857
H
Cl
OCF3
Cl
CF3
CF3
CH3
O
CH2
O
CH2CF3


P858
H
Cl
OCF3
Cl
CF2CF3
H
Br
O
CH2
O
CH2CF3


P859
H
Cl
OCF3
Cl
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P860
H
Cl
OCF3
Cl
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P861
H
Cl
OCF3
Cl
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P862
H
Cl
OCF3
Cl
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P863
H
Cl
OCF3
Cl
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P864
H
Cl
OCF3
Cl
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P865
H
Cl
OCF3
Cl
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P866
H
Cl
OCF3
Cl
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P867
H
Cl
OCF3
Cl
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P868
H
Cl
OCF3
Cl
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P869
H
Cl
OCF3
Cl
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P870
H
Cl
OCF3
Cl
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P871
H
Cl
OCF3
Cl
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P872
H
Cl
OCF3
Cl
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P873
H
Cl
OCF3
Cl
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P874
H
Cl
OCF3
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P875
H
Cl
OCF3
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P876
H
Cl
OCF3
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P877
H
Cl
OCF3
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P878
H
Cl
OCF3
Cl
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P879
H
Cl
OCF3
Cl
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P880
H
Cl
OCF3
Cl
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P881
H
Cl
OCF3
Cl
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P882
H
Cl
OCF3
Cl
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P883
H
Cl
OCF3
Cl
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P884
H
Cl
OCF3
Cl
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P885
H
Cl
OCF3
Cl
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P886
H
Cl
OCF3
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P887
H
Cl
OCF3
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P888
H
Cl
OCF3
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P889
H
Cl
OCF3
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P890
H
Cl
OCF3
Cl
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P891
H
Cl
OCF3
Cl
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P892
H
Cl
OCF3
Cl
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P893
H
Cl
OCF3
Cl
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P894
H
Cl
OCF3
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P895
H
Cl
OCF3
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P896
H
Cl
OCF3
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P897
H
Cl
OCF3
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P898
H
Cl
OCF3
Cl
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P899
H
Cl
OCF3
Cl
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P900
H
Cl
OCF3
Cl
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P901
H
Cl
OCF3
Cl
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P902
H
Cl
OCF3
Cl
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P903
H
Cl
OCF3
Cl
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P904
H
Cl
OCF3
Cl
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P905
H
Cl
OCF3
Cl
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P906
H
Cl
OCF3
Cl
CF3
H
Br
O
CH2CH2
O
CH2CF3


P907
H
Cl
OCF3
Cl
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P908
H
Cl
OCF3
Cl
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P909
H
Cl
OCF3
Cl
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P910
H
Cl
CN
Cl
CF3
H
Br
O
CH2
O
CH2CF3


P911
H
Cl
CN
Cl
CF3
H
Cl
O
CH2
O
CH2CF3


P912
H
Cl
CN
Cl
CF3
H
CF3
O
CH2
O
CH2CF3


P913
H
Cl
CN
Cl
CF3
H
CH3
O
CH2
O
CH2CF3


P914
H
Cl
CN
Cl
CF3
H
Br
O
CH2
S
CH2CF3


P915
H
Cl
CN
Cl
CF3
H
Cl
O
CH2
S
CH2CF3


P916
H
Cl
CN
Cl
CF3
H
CF3
O
CH2
S
CH2CF3


P917
H
Cl
CN
Cl
CF3
H
CH3
O
CH2
S
CH2CF3


P918
H
Cl
CN
Cl
CF3
H
Br
S
CH2
O
CH2CF3


P919
H
Cl
CN
Cl
CF3
H
Cl
S
CH2
O
CH2CF3


P920
H
Cl
CN
Cl
CF3
H
CF3
S
CH2
O
CH2CF3


P921
H
Cl
CN
Cl
CF3
H
CH3
S
CH2
O
CH2CF3


P922
H
Cl
CN
Cl
CF3
H
Br
O
CH2
O
CH2CHF2


P923
H
Cl
CN
Cl
CF3
H
Cl
O
CH2
O
CH2CHF2


P924
H
Cl
CN
Cl
CF3
H
CF3
O
CH2
O
CH2CHF2


P925
H
Cl
CN
Cl
CF3
H
CH3
O
CH2
O
CH2CHF2


P926
H
Cl
CN
Cl
CF3
CF3
Br
O
CH2
O
CH2CF3


P927
H
Cl
CN
Cl
CF3
CF3
Cl
O
CH2
O
CH2CF3


P928
H
Cl
CN
Cl
CF3
CF3
CF3
O
CH2
O
CH2CF3


P929
H
Cl
CN
Cl
CF3
CF3
CH3
O
CH2
O
CH2CF3


P930
H
Cl
CN
Cl
CF2CF3
H
Br
O
CH2
O
CH2CF3


P931
H
Cl
CN
Cl
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P932
H
Cl
CN
Cl
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P933
H
Cl
CN
Cl
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P934
H
Cl
CN
Cl
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P935
H
Cl
CN
Cl
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P936
H
Cl
CN
Cl
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P937
H
Cl
CN
Cl
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P938
H
Cl
CN
Cl
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P939
H
Cl
CN
Cl
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P940
H
Cl
CN
Cl
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P941
H
Cl
CN
Cl
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P942
H
Cl
CN
Cl
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P943
H
Cl
CN
Cl
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P944
H
Cl
CN
Cl
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P945
H
Cl
CN
Cl
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P946
H
Cl
CN
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P947
H
Cl
CN
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P948
H
Cl
CN
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P949
H
Cl
CN
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P950
H
Cl
CN
Cl
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P951
H
Cl
CN
Cl
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P952
H
Cl
CN
Cl
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P953
H
Cl
CN
Cl
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P954
H
Cl
CN
Cl
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P955
H
Cl
CN
Cl
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P956
H
Cl
CN
Cl
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P957
H
Cl
CN
Cl
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P958
H
Cl
CN
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P959
H
Cl
CN
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P960
H
Cl
CN
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P961
H
Cl
CN
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P962
H
Cl
CN
Cl
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P963
H
Cl
CN
Cl
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P964
H
Cl
CN
Cl
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P965
H
Cl
CN
Cl
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P966
H
Cl
CN
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P967
H
Cl
CN
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P968
H
Cl
CN
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P969
H
Cl
CN
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P970
H
Cl
CN
Cl
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P971
H
Cl
CN
Cl
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P972
H
Cl
CN
Cl
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P973
H
Cl
CN
Cl
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P974
H
Cl
CN
Cl
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P975
H
Cl
CN
Cl
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P976
H
Cl
CN
Cl
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P977
H
Cl
CN
Cl
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P978
H
Cl
CN
Cl
CF3
H
Br
O
CH2CH2
O
CH2CF3


P979
H
Cl
CN
Cl
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P980
H
Cl
CN
Cl
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P981
H
Cl
CN
Cl
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P982
H
CH3
H
Br
CF3
H
Br
O
CH2
O
CH2CF3


P983
H
CH3
H
Br
CF3
H
Cl
O
CH2
O
CH2CF3


P984
H
CH3
H
Br
CF3
H
CF3
O
CH2
O
CH2CF3


P985
H
CH3
H
Br
CF3
H
CH3
O
CH2
O
CH2CF3


P986
H
CH3
H
Br
CF3
H
Br
O
CH2
S
CH2CF3


P987
H
CH3
H
Br
CF3
H
Cl
O
CH2
S
CH2CF3


P988
H
CH3
H
Br
CF3
H
CF3
O
CH2
S
CH2CF3


P989
H
CH3
H
Br
CF3
H
CH3
O
CH2
S
CH2CF3


P990
H
CH3
H
Br
CF3
H
Br
S
CH2
O
CH2CF3


P991
H
CH3
H
Br
CF3
H
Cl
S
CH2
O
CH2CF3


P992
H
CH3
H
Br
CF3
H
CF3
S
CH2
O
CH2CF3


P993
H
CH3
H
Br
CF3
H
CH3
S
CH2
O
CH2CF3


P994
H
CH3
H
Br
CF3
H
Br
O
CH2
O
CH2CHF2


P995
H
CH3
H
Br
CF3
H
Cl
O
CH2
O
CH2CHF2


P996
H
CH3
H
Br
CF3
H
CF3
O
CH2
O
CH2CHF2


P997
H
CH3
H
Br
CF3
H
CH3
O
CH2
O
CH2CHF2


P998
H
CH3
H
Br
CF3
CF3
Br
O
CH2
O
CH2CF3


P999
H
CH3
H
Br
CF3
CF3
Cl
O
CH2
O
CH2CF3


P1000
H
CH3
H
Br
CF3
CF3
CF3
O
CH2
O
CH2CF3


P1001
H
CH3
H
Br
CF3
CF3
CH3
O
CH2
O
CH2CF3


P1002
H
CH3
H
Br
CF2CF3
H
Br
O
CH2
O
CH2CF3


P1003
H
CH3
H
Br
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P1004
H
CH3
H
Br
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P1005
H
CH3
H
Br
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P1006
H
CH3
H
Br
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P1007
H
CH3
H
Br
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P1008
H
CH3
H
Br
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P1009
H
CH3
H
Br
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P1010
H
CH3
H
Br
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P1011
H
CH3
H
Br
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P1012
H
CH3
H
Br
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P1013
H
CH3
H
Br
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P1014
H
CH3
H
Br
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P1015
H
CH3
H
Br
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1016
H
CH3
H
Br
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P1017
H
CH3
H
Br
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1018
H
CH3
H
Br
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P1019
H
CH3
H
Br
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1020
H
CH3
H
Br
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P1021
H
CH3
H
Br
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1022
H
CH3
H
Br
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P1023
H
CH3
H
Br
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P1024
H
CH3
H
Br
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P1025
H
CH3
H
Br
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P1026
H
CH3
H
Br
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P1027
H
CH3
H
Br
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P1028
H
CH3
H
Br
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P1029
H
CH3
H
Br
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P1030
H
CH3
H
Br
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P1031
H
CH3
H
Br
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P1032
H
CH3
H
Br
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P1033
H
CH3
H
Br
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P1034
H
CH3
H
Br
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P1035
H
CH3
H
Br
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P1036
H
CH3
H
Br
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P1037
H
CH3
H
Br
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P1038
H
CH3
H
Br
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P1039
H
CH3
H
Br
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P1040
H
CH3
H
Br
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P1041
H
CH3
H
Br
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P1042
H
CH3
H
Br
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P1043
H
CH3
H
Br
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P1044
H
CH3
H
Br
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P1045
H
CH3
H
Br
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P1046
H
CH3
H
Br
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P1047
H
CH3
H
Br
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P1048
H
CH3
H
Br
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P1049
H
CH3
H
Br
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P1050
H
CH3
H
Br
CF3
H
Br
O
CH2CH2
O
CH2CF3


P1051
H
CH3
H
Br
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P1052
H
CH3
H
Br
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P1053
H
CH3
H
Br
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P1054
H
H
F
CH3
CF3
H
Br
O
CH2
O
CH2CF3


P1055
H
H
F
CH3
CF3
H
Cl
O
CH2
O
CH2CF3


P1056
H
H
F
CH3
CF3
H
CF3
O
CH2
O
CH2CF3


P1057
H
H
F
CH3
CF3
H
CH3
O
CH2
O
CH2CF3


P1058
H
H
F
CH3
CF3
H
Br
O
CH2
S
CH2CF3


P1059
H
H
F
CH3
CF3
H
Cl
O
CH2
S
CH2CF3


P1060
H
H
F
CH3
CF3
H
CF3
O
CH2
S
CH2CF3


P1061
H
H
F
CH3
CF3
H
CH3
O
CH2
S
CH2CF3


P1062
H
H
F
CH3
CF3
H
Br
S
CH2
O
CH2CF3


P1063
H
H
F
CH3
CF3
H
Cl
S
CH2
O
CH2CF3


P1064
H
H
F
CH3
CF3
H
CF3
S
CH2
O
CH2CF3


P1065
H
H
F
CH3
CF3
H
CH3
S
CH2
O
CH2CF3


P1066
H
H
F
CH3
CF3
H
Br
O
CH2
O
CH2CHF2


P1067
H
H
F
CH3
CF3
H
Cl
O
CH2
O
CH2CHF2


P1068
H
H
F
CH3
CF3
H
CF3
O
CH2
O
CH2CHF2


P1069
H
H
F
CH3
CF3
H
CH3
O
CH2
O
CH2CHF2


P1070
H
H
F
CH3
CF3
CF3
Br
O
CH2
O
CH2CF3


P1071
H
H
F
CH3
CF3
CF3
Cl
O
CH2
O
CH2CF3


P1072
H
H
F
CH3
CF3
CF3
CF3
O
CH2
O
CH2CF3


P1073
H
H
F
CH3
CF3
CF3
CH3
O
CH2
O
CH2CF3


P1074
H
H
F
CH3
CF2CF3
H
Br
O
CH2
O
CH2CF3


P1075
H
H
F
CH3
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P1076
H
H
F
CH3
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P1077
H
H
F
CH3
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P1078
H
H
F
CH3
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P1079
H
H
F
CH3
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P1080
H
H
F
CH3
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P1081
H
H
F
CH3
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P1082
H
H
F
CH3
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P1083
H
H
F
CH3
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P1084
H
H
F
CH3
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P1085
H
H
F
CH3
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P1086
H
H
F
CH3
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P1087
H
H
F
CH3
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1088
H
H
F
CH3
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P1089
H
H
F
CH3
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1090
H
H
F
CH3
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P1091
H
H
F
CH3
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1092
H
H
F
CH3
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P1093
H
H
F
CH3
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1094
H
H
F
CH3
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P1095
H
H
F
CH3
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P1096
H
H
F
CH3
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P1097
H
H
F
CH3
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P1098
H
H
F
CH3
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P1099
H
H
F
CH3
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P1100
H
H
F
CH3
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P1101
H
H
F
CH3
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P1102
H
H
F
CH3
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P1103
H
H
F
CH3
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P1104
H
H
F
CH3
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P1105
H
H
F
CH3
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P1106
H
H
F
CH3
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P1107
H
H
F
CH3
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P1108
H
H
F
CH3
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P1109
H
H
F
CH3
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P1110
H
H
F
CH3
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P1111
H
H
F
CH3
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P1112
H
H
F
CH3
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P1113
H
H
F
CH3
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P1114
H
H
F
CH3
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P1115
H
H
F
CH3
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P1116
H
H
F
CH3
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P1117
H
H
F
CH3
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P1118
H
H
F
CH3
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P1119
H
H
F
CH3
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P1120
H
H
F
CH3
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P1121
H
H
F
CH3
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P1122
H
H
F
CH3
CF3
H
Br
O
CH2CH2
O
CH2CF3


P1123
H
H
F
CH3
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P1124
H
H
F
CH3
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P1125
H
H
F
CH3
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P1126
H
H
F
Cl
CF3
H
Cl
O
CH2
O
CH2CF3


P1127
H
H
F
Cl
CF3
H
CF3
O
CH2
O
CH2CF3


P1128
H
H
F
Cl
CF3
H
CH3
O
CH2
O
CH2CF3


P1129
H
H
F
Cl
CF3
H
Br
O
CH2
S
CH2CF3


P1130
H
H
F
Cl
CF3
H
Cl
O
CH2
S
CH2CF3


P1131
H
H
F
Cl
CF3
H
CF3
O
CH2
S
CH2CF3


P1132
H
H
F
Cl
CF3
H
CH3
O
CH2
S
CH2CF3


P1133
H
H
F
Cl
CF3
H
Br
S
CH2
O
CH2CF3


P1134
H
H
F
Cl
CF3
H
Cl
S
CH2
O
CH2CF3


P1135
H
H
F
Cl
CF3
H
CF3
S
CH2
O
CH2CF3


P1136
H
H
F
Cl
CF3
H
CH3
S
CH2
O
CH2CF3


P1137
H
H
F
Cl
CF3
H
Br
O
CH2
O
CH2CHF2


P1138
H
H
F
Cl
CF3
H
Cl
O
CH2
O
CH2CHF2


P1139
H
H
F
Cl
CF3
H
CF3
O
CH2
O
CH2CHF2


P1140
H
H
F
Cl
CF3
H
CH3
O
CH2
O
CH2CHF2


P1141
H
H
F
Cl
CF3
CF3
Br
O
CH2
O
CH2CF3


P1142
H
H
F
Cl
CF3
CF3
Cl
O
CH2
O
CH2CF3


P1143
H
H
F
Cl
CF3
CF3
CF3
O
CH2
O
CH2CF3


P1144
H
H
F
Cl
CF3
CF3
CH3
O
CH2
O
CH2CF3


P1145
H
H
F
Cl
CF2CF3
H
Br
O
CH2
O
CH2CF3


P1146
H
H
F
Cl
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P1147
H
H
F
Cl
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P1148
H
H
F
Cl
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P1149
H
H
F
Cl
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P1150
H
H
F
Cl
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P1151
H
H
F
Cl
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P1152
H
H
F
Cl
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P1153
H
H
F
Cl
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P1154
H
H
F
Cl
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P1155
H
H
F
Cl
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P1156
H
H
F
Cl
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P1157
H
H
F
Cl
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P1158
H
H
F
Cl
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1159
H
H
F
Cl
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P1160
H
H
F
Cl
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1161
H
H
F
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P1162
H
H
F
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1163
H
H
F
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P1164
H
H
F
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1165
H
H
F
Cl
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P1166
H
H
F
Cl
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P1167
H
H
F
Cl
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P1168
H
H
F
Cl
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P1169
H
H
F
Cl
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P1170
H
H
F
Cl
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P1171
H
H
F
Cl
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P1172
H
H
F
Cl
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P1173
H
H
F
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P1174
H
H
F
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P1175
H
H
F
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P1176
H
H
F
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P1177
H
H
F
Cl
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P1178
H
H
F
Cl
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P1179
H
H
F
Cl
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P1180
H
H
F
Cl
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P1181
H
H
F
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P1182
H
H
F
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P1183
H
H
F
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P1184
H
H
F
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P1185
H
H
F
Cl
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P1186
H
H
F
Cl
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P1187
H
H
F
Cl
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P1188
H
H
F
Cl
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P1189
H
H
F
Cl
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P1190
H
H
F
Cl
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P1191
H
H
F
Cl
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P1192
H
H
F
Cl
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P1193
H
H
F
Cl
CF3
H
Br
O
CH2CH2
O
CH2CF3


P1194
H
H
F
Cl
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P1195
H
H
F
Cl
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P1196
H
H
F
Cl
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P1197
H
F
F
F
CF3
H
Br
O
CH2
O
CH2CF3


P1198
H
F
F
F
CF3
H
Cl
O
CH2
O
CH2CF3


P1199
H
F
F
F
CF3
H
CF3
O
CH2
O
CH2CF3


P1200
H
F
F
F
CF3
H
CH3
O
CH2
O
CH2CF3


P1201
H
F
F
F
CF3
H
Br
O
CH2
S
CH2CF3


P1202
H
F
F
F
CF3
H
Cl
O
CH2
S
CH2CF3


P1203
H
F
F
F
CF3
H
CF3
O
CH2
S
CH2CF3


P1204
H
F
F
F
CF3
H
CH3
O
CH2
S
CH2CF3


P1205
H
F
F
F
CF3
H
Br
S
CH2
O
CH2CF3


P1206
H
F
F
F
CF3
H
Cl
S
CH2
O
CH2CF3


P1207
H
F
F
F
CF3
H
CF3
S
CH2
O
CH2CF3


P1208
H
F
F
F
CF3
H
CH3
S
CH2
O
CH2CF3


P1209
H
F
F
F
CF3
H
Br
O
CH2
O
CH2CHF2


P1210
H
F
F
F
CF3
H
Cl
O
CH2
O
CH2CHF2


P1211
H
F
F
F
CF3
H
CF3
O
CH2
O
CH2CHF2


P1212
H
F
F
F
CF3
H
CH3
O
CH2
O
CH2CHF2


P1213
H
F
F
F
CF3
CF3
Br
O
CH2
O
CH2CF3


P1214
H
F
F
F
CF3
CF3
Cl
O
CH2
O
CH2CF3


P1215
H
F
F
F
CF3
CF3
CF3
O
CH2
O
CH2CF3


P1216
H
F
F
F
CF3
CF3
CH3
O
CH2
O
CH2CF3


P1217
H
F
F
F
CF2CF3
H
Br
O
CH2
O
CH2CF3


P1218
H
F
F
F
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P1219
H
F
F
F
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P1220
H
F
F
F
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P1221
H
F
F
F
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P1222
H
F
F
F
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P1223
H
F
F
F
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P1224
H
F
F
F
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P1225
H
F
F
F
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P1226
H
F
F
F
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P1227
H
F
F
F
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P1228
H
F
F
F
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P1229
H
F
F
F
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P1230
H
F
F
F
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1231
H
F
F
F
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P1232
H
F
F
F
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1233
H
F
F
F
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P1234
H
F
F
F
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1235
H
F
F
F
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P1236
H
F
F
F
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1237
H
F
F
F
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P1238
H
F
F
F
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P1239
H
F
F
F
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P1240
H
F
F
F
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P1241
H
F
F
F
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P1242
H
F
F
F
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P1243
H
F
F
F
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P1244
H
F
F
F
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P1245
H
F
F
F
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P1246
H
F
F
F
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P1247
H
F
F
F
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P1248
H
F
F
F
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P1249
H
F
F
F
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P1250
H
F
F
F
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P1251
H
F
F
F
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P1252
H
F
F
F
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P1253
H
F
F
F
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P1254
H
F
F
F
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P1255
H
F
F
F
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P1256
H
F
F
F
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P1257
H
F
F
F
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P1258
H
F
F
F
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P1259
H
F
F
F
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P1260
H
F
F
F
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P1261
H
F
F
F
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P1262
H
F
F
F
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P1263
H
F
F
F
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P1264
H
F
F
F
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P1265
H
F
F
F
CF3
H
Br
O
CH2CH2
O
CH2CF3


P1266
H
F
F
F
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P1267
H
F
F
F
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P1268
H
F
F
F
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P1269
H
CF3
H
CF3
CF3
H
Br
O
CH2
O
CH2CF3


P1270
H
CF3
H
CF3
CF3
H
Cl
O
CH2
O
CH2CF3


P1271
H
CF3
H
CF3
CF3
H
CF3
O
CH2
O
CH2CF3


P1272
H
CF3
H
CF3
CF3
H
CH3
O
CH2
O
CH2CF3


P1273
H
CF3
H
CF3
CF3
H
Br
O
CH2
S
CH2CF3


P1274
H
CF3
H
CF3
CF3
H
Cl
O
CH2
S
CH2CF3


P1275
H
CF3
H
CF3
CF3
H
CF3
O
CH2
S
CH2CF3


P1276
H
CF3
H
CF3
CF3
H
CH3
O
CH2
S
CH2CF3


P1277
H
CF3
H
CF3
CF3
H
Br
S
CH2
O
CH2CF3


P1278
H
CF3
H
CF3
CF3
H
Cl
S
CH2
O
CH2CF3


P1279
H
CF3
H
CF3
CF3
H
CF3
S
CH2
O
CH2CF3


P1280
H
CF3
H
CF3
CF3
H
CH3
S
CH2
O
CH2CF3


P1281
H
CF3
H
CF3
CF3
H
Br
O
CH2
O
CH2CHF2


P1282
H
CF3
H
CF3
CF3
H
Cl
O
CH2
O
CH2CHF2


P1283
H
CF3
H
CF3
CF3
H
CF3
O
CH2
O
CH2CHF2


P1284
H
CF3
H
CF3
CF3
H
CH3
O
CH2
O
CH2CHF2


P1285
H
CF3
H
CF3
CF3
CF3
Br
O
CH2
O
CH2CF3


P1286
H
CF3
H
CF3
CF3
CF3
Cl
O
CH2
O
CH2CF3


P1287
H
CF3
H
CF3
CF3
CF3
CF3
O
CH2
O
CH2CF3


P1288
H
CF3
H
CF3
CF3
CF3
CH3
O
CH2
O
CH2CF3


P1289
H
CF3
H
CF3
CF2CF3
H
Br
O
CH2
O
CH2CF3


P1290
H
CF3
H
CF3
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P1291
H
CF3
H
CF3
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P1292
H
CF3
H
CF3
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P1293
H
CF3
H
CF3
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P1294
H
CF3
H
CF3
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P1295
H
CF3
H
CF3
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P1296
H
CF3
H
CF3
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P1297
H
CF3
H
CF3
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P1298
H
CF3
H
CF3
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P1299
H
CF3
H
CF3
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P1300
H
CF3
H
CF3
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P1301
H
CF3
H
CF3
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P1302
H
CF3
H
CF3
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1303
H
CF3
H
CF3
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P1304
H
CF3
H
CF3
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1305
H
CF3
H
CF3
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1306
H
CF3
H
CF3
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P1307
H
CF3
H
CF3
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1308
H
CF3
H
CF3
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P1309
H
CF3
H
CF3
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P1310
H
CF3
H
CF3
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P1311
H
CF3
H
CF3
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P1312
H
CF3
H
CF3
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P1313
H
CF3
H
CF3
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P1314
H
CF3
H
CF3
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P1315
H
CF3
H
CF3
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P1316
H
CF3
H
CF3
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P1317
H
CF3
H
CF3
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P1318
H
CF3
H
CF3
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P1319
H
CF3
H
CF3
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P1320
H
CF3
H
CF3
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P1321
H
CF3
H
CF3
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P1322
H
CF3
H
CF3
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P1323
H
CF3
H
CF3
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P1324
H
CF3
H
CF3
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P1325
H
CF3
H
CF3
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P1326
H
CF3
H
CF3
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P1327
H
CF3
H
CF3
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P1328
H
CF3
H
CF3
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P1329
H
CF3
H
CF3
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P1330
H
CF3
H
CF3
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P1331
H
CF3
H
CF3
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P1332
H
CF3
H
CF3
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P1333
H
CF3
H
CF3
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P1334
H
CF3
H
CF3
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P1335
H
CF3
H
CF3
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P1336
H
CF3
H
CF3
CF3
H
Br
O
CH2CH2
O
CH2CF3


P1337
H
CF3
H
CF3
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P1338
H
CF3
H
CF3
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P1339
H
CF3
H
CF3
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P1340
H
F
H
CF3
CF3
H
Br
O
CH2
O
CH2CF3


P1341
H
F
H
CF3
CF3
H
Cl
O
CH2
O
CH2CF3


P1342
H
F
H
CF3
CF3
H
CF3
O
CH2
O
CH2CF3


P1343
H
F
H
CF3
CF3
H
CH3
O
CH2
O
CH2CF3


P1344
H
F
H
CF3
CF3
H
Br
O
CH2
S
CH2CF3


P1345
H
F
H
CF3
CF3
H
Cl
O
CH2
S
CH2CF3


P1346
H
F
H
CF3
CF3
H
CF3
O
CH2
S
CH2CF3


P1347
H
F
H
CF3
CF3
H
CH3
O
CH2
S
CH2CF3


P1348
H
F
H
CF3
CF3
H
Br
S
CH2
O
CH2CF3


P1349
H
F
H
CF3
CF3
H
Cl
S
CH2
O
CH2CF3


P1350
H
F
H
CF3
CF3
H
CF3
S
CH2
O
CH2CF3


P1351
H
F
H
CF3
CF3
H
CH3
S
CH2
O
CH2CF3


P1352
H
F
H
CF3
CF3
H
Br
O
CH2
O
CH2CHF2


P1353
H
F
H
CF3
CF3
H
Cl
O
CH2
O
CH2CHF2


P1354
H
F
H
CF3
CF3
H
CF3
O
CH2
O
CH2CHF2


P1355
H
F
H
CF3
CF3
H
CH3
O
CH2
O
CH2CHF2


P1356
H
F
H
CF3
CF3
CF3
Br
O
CH2
O
CH2CF3


P1357
H
F
H
CF3
CF3
CF3
Cl
O
CH2
O
CH2CF3


P1358
H
F
H
CF3
CF3
CF3
CF3
O
CH2
O
CH2CF3


P1359
H
F
H
CF3
CF3
CF3
CH3
O
CH2
O
CH2CF3


P1360
H
F
H
CF3
CF2CF3
H
Br
O
CH2
O
CH2CF3


P1361
H
F
H
CF3
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P1362
H
F
H
CF3
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P1363
H
F
H
CF3
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P1364
H
F
H
CF3
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P1365
H
F
H
CF3
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P1366
H
F
H
CF3
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P1367
H
F
H
CF3
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P1368
H
F
H
CF3
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P1369
H
F
H
CF3
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P1370
H
F
H
CF3
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P1371
H
F
H
CF3
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P1372
H
F
H
CF3
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P1373
H
F
H
CF3
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1374
H
F
H
CF3
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P1375
H
F
H
CF3
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1376
H
F
H
CF3
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1377
H
F
H
CF3
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P1378
H
F
H
CF3
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1379
H
F
H
CF3
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P1380
H
F
H
CF3
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P1381
H
F
H
CF3
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P1382
H
F
H
CF3
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P1383
H
F
H
CF3
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P1384
H
F
H
CF3
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P1385
H
F
H
CF3
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P1386
H
F
H
CF3
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P1387
H
F
H
CF3
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P1388
H
F
H
CF3
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P1389
H
F
H
CF3
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P1390
H
F
H
CF3
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P1391
H
F
H
CF3
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P1392
H
F
H
CF3
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P1393
H
F
H
CF3
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P1394
H
F
H
CF3
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P1395
H
F
H
CF3
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P1396
H
F
H
CF3
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P1397
H
F
H
CF3
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P1398
H
F
H
CF3
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P1399
H
F
H
CF3
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P1400
H
F
H
CF3
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P1401
H
F
H
CF3
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P1402
H
F
H
CF3
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P1403
H
F
H
CF3
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P1404
H
F
H
CF3
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P1405
H
F
H
CF3
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P1406
H
F
H
CF3
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P1407
H
F
H
CF3
CF3
H
Br
O
CH2CH2
O
CH2CF3


P1408
H
F
H
CF3
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P1409
H
F
H
CF3
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P1410
H
F
H
CF3
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P1411
H
Cl
H
CF3
CF3
H
Br
O
CH2
O
CH2CF3


P1412
H
Cl
H
CF3
CF3
H
Cl
O
CH2
O
CH2CF3


P1413
H
Cl
H
CF3
CF3
H
CF3
O
CH2
O
CH2CF3


P1414
H
Cl
H
CF3
CF3
H
CH3
O
CH2
O
CH2CF3


P1415
H
Cl
H
CF3
CF3
H
Br
O
CH2
S
CH2CF3


P1416
H
Cl
H
CF3
CF3
H
Cl
O
CH2
S
CH2CF3


P1417
H
Cl
H
CF3
CF3
H
CF3
O
CH2
S
CH2CF3


P1418
H
Cl
H
CF3
CF3
H
CH3
O
CH2
S
CH2CF3


P1419
H
Cl
H
CF3
CF3
H
Br
S
CH2
O
CH2CF3


P1420
H
Cl
H
CF3
CF3
H
Cl
S
CH2
O
CH2CF3


P1421
H
Cl
H
CF3
CF3
H
CF3
S
CH2
O
CH2CF3


P1422
H
Cl
H
CF3
CF3
H
CH3
S
CH2
O
CH2CF3


P1423
H
Cl
H
CF3
CF3
H
Br
O
CH2
O
CH2CHF2


P1424
H
Cl
H
CF3
CF3
H
Cl
O
CH2
O
CH2CHF2


P1425
H
Cl
H
CF3
CF3
H
CF3
O
CH2
O
CH2CHF2


P1426
H
Cl
H
CF3
CF3
H
CH3
O
CH2
O
CH2CHF2


P1427
H
Cl
H
CF3
CF3
CF3
Br
O
CH2
O
CH2CF3


P1428
H
Cl
H
CF3
CF3
CF3
Cl
O
CH2
O
CH2CF3


P1429
H
Cl
H
CF3
CF3
CF3
CF3
O
CH2
O
CH2CF3


P1430
H
Cl
H
CF3
CF3
CF3
CH3
O
CH2
O
CH2CF3


P1431
H
Cl
H
CF3
CF2CF3
H
Br
O
CH2
O
CH2CF3


P1432
H
Cl
H
CF3
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P1433
H
Cl
H
CF3
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P1434
H
Cl
H
CF3
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P1435
H
Cl
H
CF3
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P1436
H
Cl
H
CF3
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P1437
H
Cl
H
CF3
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P1438
H
Cl
H
CF3
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P1439
H
Cl
H
CF3
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P1440
H
Cl
H
CF3
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P1441
H
Cl
H
CF3
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P1442
H
Cl
H
CF3
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P1443
H
Cl
H
CF3
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P1444
H
Cl
H
CF3
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1445
H
Cl
H
CF3
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P1446
H
Cl
H
CF3
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1447
H
Cl
H
CF3
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P1448
H
Cl
H
CF3
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1449
H
Cl
H
CF3
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P1450
H
Cl
H
CF3
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1451
H
Cl
H
CF3
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P1452
H
Cl
H
CF3
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P1453
H
Cl
H
CF3
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P1454
H
Cl
H
CF3
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P1455
H
Cl
H
CF3
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P1456
H
Cl
H
CF3
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P1457
H
Cl
H
CF3
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P1458
H
Cl
H
CF3
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P1459
H
Cl
H
CF3
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P1460
H
Cl
H
CF3
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P1461
H
Cl
H
CF3
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P1462
H
Cl
H
CF3
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P1463
H
Cl
H
CF3
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P1464
H
Cl
H
CF3
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P1465
H
Cl
H
CF3
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P1466
H
Cl
H
CF3
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P1467
H
Cl
H
CF3
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P1468
H
Cl
H
CF3
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P1469
H
Cl
H
CF3
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P1470
H
Cl
H
CF3
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P1471
H
Cl
H
CF3
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P1472
H
Cl
H
CF3
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P1473
H
Cl
H
CF3
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P1474
H
Cl
H
CF3
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P1475
H
Cl
H
CF3
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P1476
H
Cl
H
CF3
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P1477
H
Cl
H
CF3
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P1478
H
Cl
H
CF3
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P1479
H
Cl
H
CF3
CF3
H
Br
O
CH2CH2
O
CH2CF3


P1480
H
Cl
H
CF3
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P1481
H
Cl
H
CF3
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P1482
H
Cl
H
CF3
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P1483
H
H
F
CF3
CF3
H
Br
O
CH2
O
CH2CF3


P1484
H
H
F
CF3
CF3
H
Cl
O
CH2
O
CH2CF3


P1485
H
H
F
CF3
CF3
H
CF3
O
CH2
O
CH2CF3


P1486
H
H
F
CF3
CF3
H
CH3
O
CH2
O
CH2CF3


P1487
H
H
F
CF3
CF3
H
Br
O
CH2
S
CH2CF3


P1488
H
H
F
CF3
CF3
H
Cl
O
CH2
S
CH2CF3


P1489
H
H
F
CF3
CF3
H
CF3
O
CH2
S
CH2CF3


P1490
H
H
F
CF3
CF3
H
CH3
O
CH2
S
CH2CF3


P1491
H
H
F
CF3
CF3
H
Br
S
CH2
O
CH2CF3


P1492
H
H
F
CF3
CF3
H
Cl
S
CH2
O
CH2CF3


P1493
H
H
F
CF3
CF3
H
CF3
S
CH2
O
CH2CF3


P1494
H
H
F
CF3
CF3
H
CH3
S
CH2
O
CH2CF3


P1495
H
H
F
CF3
CF3
H
Br
O
CH2
O
CH2CHF2


P1496
H
H
F
CF3
CF3
H
Cl
O
CH2
O
CH2CHF2


P1497
H
H
F
CF3
CF3
H
CF3
O
CH2
O
CH2CHF2


P1498
H
H
F
CF3
CF3
H
CH3
O
CH2
O
CH2CHF2


P1499
H
H
F
CF3
CF3
CF3
Br
O
CH2
O
CH2CF3


P1500
H
H
F
CF3
CF3
CF3
Cl
O
CH2
O
CH2CF3


P1501
H
H
F
CF3
CF3
CF3
CF3
O
CH2
O
CH2CF3


P1502
H
H
F
CF3
CF3
CF3
CH3
O
CH2
O
CH2CF3


P1503
H
H
F
CF3
CF2CF3
H
Br
O
CH2
O
CH2CF3


P1504
H
H
F
CF3
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P1505
H
H
F
CF3
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P1506
H
H
F
CF3
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P1507
H
H
F
CF3
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P1508
H
H
F
CF3
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P1509
H
H
F
CF3
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P1510
H
H
F
CF3
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P1511
H
H
F
CF3
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P1512
H
H
F
CF3
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P1513
H
H
F
CF3
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P1514
H
H
F
CF3
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P1515
H
H
F
CF3
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P1516
H
H
F
CF3
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1517
H
H
F
CF3
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P1518
H
H
F
CF3
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1519
H
H
F
CF3
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P1520
H
H
F
CF3
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1521
H
H
F
CF3
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P1522
H
H
F
CF3
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1523
H
H
F
CF3
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P1524
H
H
F
CF3
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P1525
H
H
F
CF3
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P1526
H
H
F
CF3
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P1527
H
H
F
CF3
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P1528
H
H
F
CF3
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P1529
H
H
F
CF3
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P1530
H
H
F
CF3
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P1531
H
H
F
CF3
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P1532
H
H
F
CF3
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P1533
H
H
F
CF3
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P1534
H
H
F
CF3
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P1535
H
H
F
CF3
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P1536
H
H
F
CF3
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P1537
H
H
F
CF3
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P1538
H
H
F
CF3
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P1539
H
H
F
CF3
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P1540
H
H
F
CF3
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P1541
H
H
F
CF3
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P1542
H
H
F
CF3
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P1543
H
H
F
CF3
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P1544
H
H
F
CF3
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P1545
H
H
F
CF3
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P1546
H
H
F
CF3
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P1547
H
H
F
CF3
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P1548
H
H
F
CF3
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P1549
H
H
F
CF3
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P1550
H
H
F
CF3
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P1551
H
H
F
CF3
CF3
H
Br
O
CH2CH2
O
CH2CF3


P1552
H
H
F
CF3
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P1553
H
H
F
CF3
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P1554
H
H
F
CF3
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P1555
H
Cl
Cl
Cl
CF3
H
H
O
CH2
O
CH2CF3


P1556
H
Cl
Cl
Cl
CF3
H
CF3
O
CH2
O
CH2CF3


P1557
H
Cl
Cl
Cl
CF3
H
H
O
CH2
S
CH2CF3


P1558
H
Cl
Cl
Cl
CF3
H
Cl
O
CH2
S
CH2CF3


P1559
H
Cl
Cl
Cl
CF3
H
CF3
O
CH2
S
CH2CF3


P1560
H
Cl
Cl
Cl
CF3
H
CH3
O
CH2
S
CH2CF3


P1561
H
Cl
Cl
Cl
CF3
H
H
S
CH2
O
CH2CF3


P1562
H
Cl
Cl
Cl
CF3
H
Cl
S
CH2
O
CH2CF3


P1563
H
Cl
Cl
Cl
CF3
H
CF3
S
CH2
O
CH2CF3


P1564
H
Cl
Cl
Cl
CF3
H
CH3
S
CH2
O
CH2CF3


P1565
H
Cl
Cl
Cl
CF3
H
H
O
CH2
O
CH2CHF2


P1566
H
Cl
Cl
Cl
CF3
H
CF3
O
CH2
O
CH2CHF2


P1567
H
Cl
Cl
Cl
CF3
H
CH3
O
CH2
O
CH2CHF2


P1568
H
Cl
Cl
Cl
CF3
H
H
O
CH2
O
CH2CH2F


P1569
H
Cl
Cl
Cl
CF3
H
Br
O
CH2
O
CH2CH2F


P1570
H
Cl
Cl
Cl
CF3
H
Cl
O
CH2
O
CH2CH2F


P1571
H
Cl
Cl
Cl
CF3
H
CF3
O
CH2
O
CH2CH2F


P1572
H
Cl
Cl
Cl
CF3
H
CH3
O
CH2
O
CH2CH2F


P1573
H
Cl
Cl
Cl
CF3
H
H
O
CH2
O
CH2CH3


P1574
H
Cl
Cl
Cl
CF3
H
Br
O
CH2
O
CH2CH3


P1575
H
Cl
Cl
Cl
CF3
H
Cl
O
CH2
O
CH2CH3


P1576
H
Cl
Cl
Cl
CF3
H
CF3
O
CH2
O
CH2CH3


P1577
H
Cl
Cl
Cl
CF3
H
CH3
O
CH2
O
CH2CH3


P1578
H
Cl
Cl
Cl
CF3
CF3
H
O
CH2
O
CH2CF3


P1579
H
Cl
Cl
Cl
CF3
CF3
Br
O
CH2
O
CH2CF3


P1580
H
Cl
Cl
Cl
CF3
CF3
Cl
O
CH2
O
CH2CF3


P1581
H
Cl
Cl
Cl
CF3
CF3
CF3
O
CH2
O
CH2CF3


P1582
H
Cl
Cl
Cl
CF3
CF3
CH3
O
CH2
O
CH2CF3


P1583
H
Cl
Cl
Cl
CF2CF3
H
H
O
CH2
O
CH2CF3


P1584
H
Cl
Cl
Cl
CF2CF3
H
Br
O
CH2
O
CH2CF3


P1585
H
Cl
Cl
Cl
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P1586
H
Cl
Cl
Cl
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P1587
H
Cl
Cl
Cl
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P1588
H
Cl
Cl
Cl
CF3
H
H
O
CH2
O
CH(CH3)CF3


P1589
H
Cl
Cl
Cl
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P1590
H
Cl
Cl
Cl
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P1591
H
Cl
Cl
Cl
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P1592
H
Cl
Cl
Cl
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P1593
H
Cl
Cl
Cl
CF3
CF3
H
O
CH(CH3)
O
CH2CF3


P1594
H
Cl
Cl
Cl
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P1595
H
Cl
Cl
Cl
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P1596
H
Cl
Cl
Cl
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P1597
H
Cl
Cl
Cl
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P1598
H
Cl
Cl
Cl
CF2CF3
H
H
O
CH (CH3)
O
CH2CF3


P1599
H
Cl
Cl
Cl
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P1600
H
Cl
Cl
Cl
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1601
H
Cl
Cl
Cl
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P1602
H
Cl
Cl
Cl
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1603
H
Cl
Cl
Cl
CF3
H
H
O
CH(CH3)
O
CH2CF3


P1604
H
Cl
Cl
Cl
CF3
H
H
O
CH(CH3)
S
CH2CF3


P1605
H
Cl
Cl
Cl
CF3
H
H
S
CH(CH3)
O
CH2CF3


P1606
H
Cl
Cl
Cl
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P1607
H
Cl
Cl
Cl
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P1608
H
Cl
Cl
Cl
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P1609
H
Cl
Cl
Cl
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P1610
H
Cl
Cl
Cl
CF3
H
H
O
CH(CH3)
O
CH2CHF2


P1611
H
Cl
Cl
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P1612
H
Cl
Cl
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P1613
H
Cl
Cl
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P1614
H
Cl
Cl
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P1615
H
Cl
Cl
Cl
CF3
H
H
O
CH(CH3)
O
CH2CH2F


P1616
H
Cl
Cl
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CH2F


P1617
H
Cl
Cl
Cl
CF3
H
Cl
O
CH(CH3)
O
CH2CH2F


P1618
H
Cl
Cl
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CH2F


P1619
H
Cl
Cl
Cl
CF3
H
CH3
O
CH(CH3)
O
CH2CH2F


P1620
H
Cl
Cl
Cl
CF3
H
H
O
CH(CH3)
O
CH2CH3


P1621
H
Cl
Cl
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CH3


P1622
H
Cl
Cl
Cl
CF3
H
Cl
O
CH(CH3)
O
CH2CH3


P1623
H
Cl
Cl
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CH3


P1624
H
Cl
Cl
Cl
CF3
H
CH3
O
CH(CH3)
O
CH2CH3


P1625
H
Cl
Cl
Cl
CF3
H
H
O
CH(CH3)
O
CH(CH3)CF3


P1626
H
Cl
Cl
Cl
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P1627
H
Cl
Cl
Cl
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P1628
H
Cl
Cl
Cl
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P1629
H
Cl
Cl
Cl
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P1630
H
Cl
Cl
Cl
CF3
H
H
O
CH(CH3)
O
CH2CH2CF3


P1631
H
Cl
Cl
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P1632
H
Cl
Cl
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P1633
H
Cl
Cl
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P1634
H
Cl
Cl
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P1635
H
Cl
Cl
Cl
CF3
H
H
O
CH(CH2CH3)
O
CH2CF3


P1636
H
Cl
Cl
Cl
CF3
H
H
O
C(CH3)2
O
CH2CF3


P1637
H
Cl
Cl
Cl
CF3
H
H
O
CH2CH2
O
CH2CF3


P1638
H
Cl
Cl
Cl
CF3
H
Br
O
CH2CH2
O
CH2CF3


P1639
H
Cl
Cl
Cl
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P1640
H
Cl
Cl
Cl
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P1641
H
Cl
Cl
Cl
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P1642
H
Cl
H
Cl
CF3
H
H
O
CH2
O
CH2CF3


P1643
H
Cl
H
Cl
CF3
H
Br
O
CH2
O
CH2CF3


P1644
H
Cl
H
Cl
CF3
H
CF3
O
CH2
O
CH2CF3


P1645
H
Cl
H
Cl
CF3
H
H
O
CH2
S
CH2CF3


P1646
H
Cl
H
Cl
CF3
H
Br
O
CH2
S
CH2CF3


P1647
H
Cl
H
Cl
CF3
H
Cl
O
CH2
S
CH2CF3


P1648
H
Cl
H
Cl
CF3
H
CF3
O
CH2
S
CH2CF3


P1649
H
Cl
H
Cl
CF3
H
CH3
O
CH2
S
CH2CF3


P1650
H
Cl
H
Cl
CF3
H
H
S
CH2
O
CH2CF3


P1651
H
Cl
H
Cl
CF3
H
Br
S
CH2
O
CH2CF3


P1652
H
Cl
H
Cl
CF3
H
Cl
S
CH2
O
CH2CF3


P1653
H
Cl
H
Cl
CF3
H
CF3
S
CH2
O
CH2CF3


P1654
H
Cl
H
Cl
CF3
H
CH3
S
CH2
O
CH2CF3


P1655
H
Cl
H
Cl
CF3
H
H
O
CH2
O
CH2CHF2


P1656
H
Cl
H
Cl
CF3
H
Br
O
CH2
O
CH2CHF2


P1657
H
Cl
H
Cl
CF3
H
Cl
O
CH2
O
CH2CHF2


P1658
H
Cl
H
Cl
CF3
H
CF3
O
CH2
O
CH2CHF2


P1659
H
Cl
H
Cl
CF3
H
CH3
O
CH2
O
CH2CHF2


P1660
H
Cl
H
Cl
CF3
H
H
O
CH2
O
CH2CH2F


P1661
H
Cl
H
Cl
CF3
H
Br
O
CH2
O
CH2CH2F


P1662
H
Cl
H
Cl
CF3
H
Cl
O
CH2
O
CH2CH2F


P1663
H
Cl
H
Cl
CF3
H
CF3
O
CH2
O
CH2CH2F


P1664
H
Cl
H
Cl
CF3
H
CH3
O
CH2
O
CH2CH2F


P1665
H
Cl
H
Cl
CF3
H
H
O
CH2
O
CH2CH3


P1666
H
Cl
H
Cl
CF3
H
Br
O
CH2
O
CH2CH3


P1667
H
Cl
H
Cl
CF3
H
Cl
O
CH2
O
CH2CH3


P1668
H
Cl
H
Cl
CF3
H
CF3
O
CH2
O
CH2CH3


P1669
H
Cl
H
Cl
CF3
H
CH3
O
CH2
O
CH2CH3


P1670
H
Cl
H
Cl
CF3
CF3
H
O
CH2
O
CH2CF3


P1671
H
Cl
H
Cl
CF3
CF3
Br
O
CH2
O
CH2CF3


P1672
H
Cl
H
Cl
CF3
CF3
Cl
O
CH2
O
CH2CF3


P1673
H
Cl
H
Cl
CF3
CF3
CF3
O
CH2
O
CH2CF3


P1674
H
Cl
H
Cl
CF3
CF3
CH3
O
CH2
O
CH2CF3


P1675
H
Cl
H
Cl
CF2CF3
H
H
O
CH2
O
CH2CF3


P1676
H
Cl
H
Cl
CF2CF3
H
Br
O
CH2
O
CH2CF3


P1677
H
Cl
H
Cl
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P1678
H
Cl
H
Cl
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P1679
H
Cl
H
Cl
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P1680
H
Cl
H
Cl
CF3
H
H
O
CH2
O
CH(CH3)CF3


P1681
H
Cl
H
Cl
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P1682
H
Cl
H
Cl
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P1683
H
Cl
H
Cl
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P1684
H
Cl
H
Cl
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P1685
H
Cl
H
Cl
CF3
CF3
H
O
CH(CH3)
O
CH2CF3


P1686
H
Cl
H
Cl
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P1687
H
Cl
H
Cl
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P1688
H
Cl
H
Cl
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P1689
H
Cl
H
Cl
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P1690
H
Cl
H
Cl
CF2CF3
H
H
O
CH (CH3)
O
CH2CF3


P1691
H
Cl
H
Cl
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P1692
H
Cl
H
Cl
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1693
H
Cl
H
Cl
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P1694
H
Cl
H
Cl
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1695
H
Cl
H
Cl
CF3
H
H
O
CH(CH3)
O
CH2CF3


P1696
H
Cl
H
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P1697
H
Cl
H
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1698
H
Cl
H
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P1699
H
Cl
H
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1700
H
Cl
H
Cl
CF3
H
H
O
CH(CH3)
S
CH2CF3


P1701
H
Cl
H
Cl
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P1702
H
Cl
H
Cl
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P1703
H
Cl
H
Cl
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P1704
H
Cl
H
Cl
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P1705
H
Cl
H
Cl
CF3
H
H
S
CH(CH3)
O
CH2CF3


P1706
H
Cl
H
Cl
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P1707
H
Cl
H
Cl
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P1708
H
Cl
H
Cl
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P1709
H
Cl
H
Cl
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P1710
H
Cl
H
Cl
CF3
H
H
O
CH(CH3)
O
CH2CHF2


P1711
H
Cl
H
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P1712
H
Cl
H
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P1713
H
Cl
H
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P1714
H
Cl
H
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P1715
H
Cl
H
Cl
CF3
H
H
O
CH(CH3)
O
CH2CH2F


P1716
H
Cl
H
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CH2F


P1717
H
Cl
H
Cl
CF3
H
Cl
O
CH(CH3)
O
CH2CH2F


P1718
H
Cl
H
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CH2F


P1719
H
Cl
H
Cl
CF3
H
CH3
O
CH(CH3)
O
CH2CH2F


P1720
H
Cl
H
Cl
CF3
H
H
O
CH(CH3)
O
CH2CH3


P1721
H
Cl
H
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CH3


P1722
H
Cl
H
Cl
CF3
H
Cl
O
CH(CH3)
O
CH2CH3


P1723
H
Cl
H
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CH3


P1724
H
Cl
H
Cl
CF3
H
CH3
O
CH(CH3)
O
CH2CH3


P1725
H
Cl
H
Cl
CF3
H
H
O
CH(CH3)
O
CH(CH3)CF3


P1726
H
Cl
H
Cl
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P1727
H
Cl
H
Cl
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P1728
H
Cl
H
Cl
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P1729
H
Cl
H
Cl
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P1730
H
Cl
H
Cl
CF3
H
H
O
CH(CH3)
O
CH2CH2CF3


P1731
H
Cl
H
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P1732
H
Cl
H
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P1733
H
Cl
H
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P1734
H
Cl
H
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P1735
H
Cl
H
Cl
CF3
H
H
O
CH(CH2CH3)
O
CH2CF3


P1736
H
Cl
H
Cl
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P1737
H
Cl
H
Cl
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P1738
H
Cl
H
Cl
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P1739
H
Cl
H
Cl
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P1740
H
Cl
H
Cl
CF3
H
H
O
C(CH3)2
O
CH2CF3


P1741
H
Cl
H
Cl
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P1742
H
Cl
H
Cl
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P1743
H
Cl
H
Cl
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P1744
H
Cl
H
Cl
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P1745
H
Cl
H
Cl
CF3
H
H
O
CH2CH2
O
CH2CF3


P1746
H
Cl
H
Cl
CF3
H
Br
O
CH2CH2
O
CH2CF3


P1747
H
Cl
H
Cl
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P1748
H
Cl
H
Cl
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P1749
H
Cl
H
Cl
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P1750
H
H
Cl
Cl
CF3
H
H
O
CH2
O
CH2CF3


P1751
H
H
Cl
Cl
CF3
H
Br
O
CH2
O
CH2CF3


P1752
H
H
Cl
Cl
CF3
H
Cl
O
CH2
O
CH2CF3


P1753
H
H
Cl
Cl
CF3
H
CF3
O
CH2
O
CH2CF3


P1754
H
H
Cl
Cl
CF3
H
CH3
O
CH2
O
CH2CF3


P1755
H
H
Cl
Cl
CF3
H
H
O
CH2
S
CH2CF3


P1756
H
H
Cl
Cl
CF3
H
Br
O
CH2
S
CH2CF3


P1757
H
H
Cl
Cl
CF3
H
Cl
O
CH2
S
CH2CF3


P1758
H
H
Cl
Cl
CF3
H
CF3
O
CH2
S
CH2CF3


P1759
H
H
Cl
Cl
CF3
H
CH3
O
CH2
S
CH2CF3


P1760
H
H
Cl
Cl
CF3
H
H
S
CH2
O
CH2CF3


P1761
H
H
Cl
Cl
CF3
H
Br
S
CH2
O
CH2CF3


P1762
H
H
Cl
Cl
CF3
H
Cl
S
CH2
O
CH2CF3


P1763
H
H
Cl
Cl
CF3
H
CF3
S
CH2
O
CH2CF3


P1764
H
H
Cl
Cl
CF3
H
CH3
S
CH2
O
CH2CF3


P1765
H
H
Cl
Cl
CF3
H
H
O
CH2
O
CH2CHF2


P1766
H
H
Cl
Cl
CF3
H
Br
O
CH2
O
CH2CHF2


P1767
H
H
Cl
Cl
CF3
H
Cl
O
CH2
O
CH2CHF2


P1768
H
H
Cl
Cl
CF3
H
CF3
O
CH2
O
CH2CHF2


P1769
H
H
Cl
Cl
CF3
H
CH3
O
CH2
O
CH2CHF2


P1770
H
H
Cl
Cl
CF3
H
H
O
CH2
O
CH2CH2F


P1771
H
H
Cl
Cl
CF3
H
Br
O
CH2
O
CH2CH2F


P1772
H
H
Cl
Cl
CF3
H
Cl
O
CH2
O
CH2CH2F


P1773
H
H
Cl
Cl
CF3
H
CF3
O
CH2
O
CH2CH2F


P1774
H
H
Cl
Cl
CF3
H
CH3
O
CH2
O
CH2CH2F


P1775
H
H
Cl
Cl
CF3
H
H
O
CH2
O
CH2CH3


P1776
H
H
Cl
Cl
CF3
H
Br
O
CH2
O
CH2CH3


P1777
H
H
Cl
Cl
CF3
H
Cl
O
CH2
O
CH2CH3


P1778
H
H
Cl
Cl
CF3
H
CF3
O
CH2
O
CH2CH3


P1779
H
H
Cl
Cl
CF3
H
CH3
O
CH2
O
CH2CH3


P1780
H
H
Cl
Cl
CF3
CF3
H
O
CH2
O
CH2CF3


P1781
H
H
Cl
Cl
CF3
CF3
Br
O
CH2
O
CH2CF3


P1782
H
H
Cl
Cl
CF3
CF3
Cl
O
CH2
O
CH2CF3


P1783
H
H
Cl
Cl
CF3
CF3
CF3
O
CH2
O
CH2CF3


P1784
H
H
Cl
Cl
CF3
CF3
CH3
O
CH2
O
CH2CF3


P1785
H
H
Cl
Cl
CF2CF3
H
H
O
CH2
O
CH2CF3


P1786
H
H
Cl
Cl
CF2CF3
H
Br
O
CH2
O
CH2CF3


P1787
H
H
Cl
Cl
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P1788
H
H
Cl
Cl
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P1789
H
H
Cl
Cl
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P1790
H
H
Cl
Cl
CF3
H
H
O
CH2
O
CH(CH3)CF3


P1791
H
H
Cl
Cl
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P1792
H
H
Cl
Cl
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P1793
H
H
Cl
Cl
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P1794
H
H
Cl
Cl
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P1795
H
H
Cl
Cl
CF3
CF3
H
O
CH(CH3)
O
CH2CF3


P1796
H
H
Cl
Cl
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P1797
H
H
Cl
Cl
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P1798
H
H
Cl
Cl
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P1799
H
H
Cl
Cl
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P1800
H
H
Cl
Cl
CF2CF3
H
H
O
CH (CH3)
O
CH2CF3


P1801
H
H
Cl
Cl
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P1802
H
H
Cl
Cl
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1803
H
H
Cl
Cl
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P1804
H
H
Cl
Cl
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1805
H
H
Cl
Cl
CF3
H
H
O
CH(CH3)
O
CH2CF3


P1806
H
H
Cl
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P1807
H
H
Cl
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1808
H
H
Cl
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P1809
H
H
Cl
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1810
H
H
Cl
Cl
CF3
H
H
O
CH(CH3)
S
CH2CF3


P1811
H
H
Cl
Cl
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P1812
H
H
Cl
Cl
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P1813
H
H
Cl
Cl
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P1814
H
H
Cl
Cl
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P1815
H
H
Cl
Cl
CF3
H
H
S
CH(CH3)
O
CH2CF3


P1816
H
H
Cl
Cl
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P1817
H
H
Cl
Cl
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P1818
H
H
Cl
Cl
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P1819
H
H
Cl
Cl
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P1820
H
H
Cl
Cl
CF3
H
H
O
CH(CH3)
O
CH2CHF2


P1821
H
H
Cl
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P1822
H
H
Cl
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P1823
H
H
Cl
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P1824
H
H
Cl
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P1825
H
H
Cl
Cl
CF3
H
H
O
CH(CH3)
O
CH2CH2F


P1826
H
H
Cl
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CH2F


P1827
H
H
Cl
Cl
CF3
H
Cl
O
CH(CH3)
O
CH2CH2F


P1828
H
H
Cl
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CH2F


P1829
H
H
Cl
Cl
CF3
H
CH3
O
CH(CH3)
O
CH2CH2F


P1830
H
H
Cl
Cl
CF3
H
H
O
CH(CH3)
O
CH2CH3


P1831
H
H
Cl
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CH3


P1832
H
H
Cl
Cl
CF3
H
Cl
O
CH(CH3)
O
CH2CH3


P1833
H
H
Cl
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CH3


P1834
H
H
Cl
Cl
CF3
H
CH3
O
CH(CH3)
O
CH2CH3


P1835
H
H
Cl
Cl
CF3
H
H
O
CH(CH3)
O
CH(CH3)CF3


P1836
H
H
Cl
Cl
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P1837
H
H
Cl
Cl
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P1838
H
H
Cl
Cl
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P1839
H
H
Cl
Cl
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P1840
H
H
Cl
Cl
CF3
H
H
O
CH(CH3)
O
CH2CH2CF3


P1841
H
H
Cl
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P1842
H
H
Cl
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P1843
H
H
Cl
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P1844
H
H
Cl
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P1845
H
H
Cl
Cl
CF3
H
H
O
CH(CH2CH3)
O
CH2CF3


P1846
H
H
Cl
Cl
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P1847
H
H
Cl
Cl
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P1848
H
H
Cl
Cl
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P1849
H
H
Cl
Cl
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P1850
H
H
Cl
Cl
CF3
H
H
O
C(CH3)2
O
CH2CF3


P1851
H
H
Cl
Cl
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P1852
H
H
Cl
Cl
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P1853
H
H
Cl
Cl
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P1854
H
H
Cl
Cl
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P1855
H
H
Cl
Cl
CF3
H
H
O
CH2CH2
O
CH2CF3


P1856
H
H
Cl
Cl
CF3
H
Br
O
CH2CH2
O
CH2CF3


P1857
H
H
Cl
Cl
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P1858
H
H
Cl
Cl
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P1859
H
H
Cl
Cl
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P1860
H
Cl
F
Cl
CF3
H
H
O
CH2
O
CH2CF3


P1861
H
Cl
F
Cl
CF3
H
Cl
O
CH2
O
CH2CF3


P1862
H
Cl
F
Cl
CF3
H
CF3
O
CH2
O
CH2CF3


P1863
H
Cl
F
Cl
CF3
H
H
O
CH2
S
CH2CF3


P1864
H
Cl
F
Cl
CF3
H
Br
O
CH2
S
CH2CF3


P1865
H
Cl
F
Cl
CF3
H
Cl
O
CH2
S
CH2CF3


P1866
H
Cl
F
Cl
CF3
H
CF3
O
CH2
S
CH2CF3


P1867
H
Cl
F
Cl
CF3
H
CH3
O
CH2
S
CH2CF3


P1868
H
Cl
F
Cl
CF3
H
H
S
CH2
O
CH2CF3


P1869
H
Cl
F
Cl
CF3
H
Br
S
CH2
O
CH2CF3


P1870
H
Cl
F
Cl
CF3
H
Cl
S
CH2
O
CH2CF3


P1871
H
Cl
F
Cl
CF3
H
CF3
S
CH2
O
CH2CF3


P1872
H
Cl
F
Cl
CF3
H
CH3
S
CH2
O
CH2CF3


P1873
H
Cl
F
Cl
CF3
H
H
O
CH2
O
CH2CHF2


P1874
H
Cl
F
Cl
CF3
H
Br
O
CH2
O
CH2CHF2


P1875
H
Cl
F
Cl
CF3
H
Cl
O
CH2
O
CH2CHF2


P1876
H
Cl
F
Cl
CF3
H
CF3
O
CH2
O
CH2CHF2


P1877
H
Cl
F
Cl
CF3
H
CH3
O
CH2
O
CH2CHF2


P1878
H
Cl
F
Cl
CF3
H
H
O
CH2
O
CH2CH2F


P1879
H
Cl
F
Cl
CF3
H
Br
O
CH2
O
CH2CH2F


P1880
H
Cl
F
Cl
CF3
H
Cl
O
CH2
O
CH2CH2F


P1881
H
Cl
F
Cl
CF3
H
CF3
O
CH2
O
CH2CH2F


P1882
H
Cl
F
Cl
CF3
H
CH3
O
CH2
O
CH2CH2F


P1883
H
Cl
F
Cl
CF3
H
H
O
CH2
O
CH2CH3


P1884
H
Cl
F
Cl
CF3
H
Br
O
CH2
O
CH2CH3


P1885
H
Cl
F
Cl
CF3
H
Cl
O
CH2
O
CH2CH3


P1886
H
Cl
F
Cl
CF3
H
CF3
O
CH2
O
CH2CH3


P1887
H
Cl
F
Cl
CF3
H
CH3
O
CH2
O
CH2CH3


P1888
H
Cl
F
Cl
CF3
CF3
H
O
CH2
O
CH2CF3


P1889
H
Cl
F
Cl
CF3
CF3
Br
O
CH2
O
CH2CF3


P1890
H
Cl
F
Cl
CF3
CF3
Cl
O
CH2
O
CH2CF3


P1891
H
Cl
F
Cl
CF3
CF3
CF3
O
CH2
O
CH2CF3


P1892
H
Cl
F
Cl
CF3
CF3
CH3
O
CH2
O
CH2CF3


P1893
H
Cl
F
Cl
CF2CF3
H
H
O
CH2
O
CH2CF3


P1894
H
Cl
F
Cl
CF2CF3
H
Br
O
CH2
O
CH2CF3


P1895
H
Cl
F
Cl
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P1896
H
Cl
F
Cl
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P1897
H
Cl
F
Cl
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P1898
H
Cl
F
Cl
CF3
H
H
O
CH2
O
CH(CH3)CF3


P1899
H
Cl
F
Cl
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P1900
H
Cl
F
Cl
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P1901
H
Cl
F
Cl
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P1902
H
Cl
F
Cl
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P1903
H
Cl
F
Cl
CF3
CF3
H
O
CH(CH3)
O
CH2CF3


P1904
H
Cl
F
Cl
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P1905
H
Cl
F
Cl
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P1906
H
Cl
F
Cl
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P1907
H
Cl
F
Cl
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P1908
H
Cl
F
Cl
CF2CF3
H
H
O
CH (CH3)
O
CH2CF3


P1909
H
Cl
F
Cl
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P1910
H
Cl
F
Cl
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1911
H
Cl
F
Cl
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P1912
H
Cl
F
Cl
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1913
H
Cl
F
Cl
CF3
H
H
O
CH(CH3)
O
CH2CF3


P1914
H
Cl
F
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CF3


P1915
H
Cl
F
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P1916
H
Cl
F
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CF3


P1917
H
Cl
F
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P1918
H
Cl
F
Cl
CF3
H
H
O
CH(CH3)
S
CH2CF3


P1919
H
Cl
F
Cl
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P1920
H
Cl
F
Cl
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P1921
H
Cl
F
Cl
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P1922
H
Cl
F
Cl
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P1923
H
Cl
F
Cl
CF3
H
H
S
CH(CH3)
O
CH2CF3


P1924
H
Cl
F
Cl
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P1925
H
Cl
F
Cl
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P1926
H
Cl
F
Cl
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P1927
H
Cl
F
Cl
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P1928
H
Cl
F
Cl
CF3
H
H
O
CH(CH3)
O
CH2CHF2


P1929
H
Cl
F
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P1930
H
Cl
F
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P1931
H
Cl
F
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P1932
H
Cl
F
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P1933
H
Cl
F
Cl
CF3
H
H
O
CH(CH3)
O
CH2CH2F


P1934
H
Cl
F
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CH2F


P1935
H
Cl
F
Cl
CF3
H
Cl
O
CH(CH3)
O
CH2CH2F


P1936
H
Cl
F
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CH2F


P1937
H
Cl
F
Cl
CF3
H
CH3
O
CH(CH3)
O
CH2CH2F


P1938
H
Cl
F
Cl
CF3
H
H
O
CH(CH3)
O
CH2CH3


P1939
H
Cl
F
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CH3


P1940
H
Cl
F
Cl
CF3
H
Cl
O
CH(CH3)
O
CH2CH3


P1941
H
Cl
F
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CH3


P1942
H
Cl
F
Cl
CF3
H
CH3
O
CH(CH3)
O
CH2CH3


P1943
H
Cl
F
Cl
CF3
H
H
O
CH(CH3)
O
CH(CH3)CF3


P1944
H
Cl
F
Cl
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P1945
H
Cl
F
Cl
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P1946
H
Cl
F
Cl
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P1947
H
Cl
F
Cl
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P1948
H
Cl
F
Cl
CF3
H
H
O
CH(CH3)
O
CH2CH2CF3


P1949
H
Cl
F
Cl
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P1950
H
Cl
F
Cl
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P1951
H
Cl
F
Cl
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P1952
H
Cl
F
Cl
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P1953
H
Cl
F
Cl
CF3
H
H
O
CH(CH2CH3)
O
CH2CF3


P1954
H
Cl
F
Cl
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P1955
H
Cl
F
Cl
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P1956
H
Cl
F
Cl
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P1957
H
Cl
F
Cl
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P1958
H
Cl
F
Cl
CF3
H
H
O
C(CH3)2
O
CH2CF3


P1959
H
Cl
F
Cl
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P1960
H
Cl
F
Cl
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P1961
H
Cl
F
Cl
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P1962
H
Cl
F
Cl
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P1963
H
Cl
F
Cl
CF3
H
H
O
CH2CH2
O
CH2CF3


P1964
H
Cl
F
Cl
CF3
H
Br
O
CH2CH2
O
CH2CF3


P1965
H
Cl
F
Cl
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P1966
H
Cl
F
Cl
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P1967
H
Cl
F
Cl
CF3
H
CH3
O
CH2CH2
O
CH2CF3


P1968
H
Br
H
Br
CF3
H
H
O
CH2
O
CH2CF3


P1969
H
Br
H
Br
CF3
H
Br
O
CH2
O
CH2CF3


P1970
H
Br
H
Br
CF3
H
Cl
O
CH2
O
CH2CF3


P1971
H
Br
H
Br
CF3
H
CF3
O
CH2
O
CH2CF3


P1972
H
Br
H
Br
CF3
H
CH3
O
CH2
O
CH2CF3


P1973
H
Br
H
Br
CF3
H
H
O
CH2
S
CH2CF3


P1974
H
Br
H
Br
CF3
H
Br
O
CH2
S
CH2CF3


P1975
H
Br
H
Br
CF3
H
Cl
O
CH2
S
CH2CF3


P1976
H
Br
H
Br
CF3
H
CF3
O
CH2
S
CH2CF3


P1977
H
Br
H
Br
CF3
H
CH3
O
CH2
S
CH2CF3


P1978
H
Br
H
Br
CF3
H
H
S
CH2
O
CH2CF3


P1979
H
Br
H
Br
CF3
H
Br
S
CH2
O
CH2CF3


P1980
H
Br
H
Br
CF3
H
Cl
S
CH2
O
CH2CF3


P1981
H
Br
H
Br
CF3
H
CF3
S
CH2
O
CH2CF3


P1982
H
Br
H
Br
CF3
H
CH3
S
CH2
O
CH2CF3


P1983
H
Br
H
Br
CF3
H
H
O
CH2
O
CH2CHF2


P1984
H
Br
H
Br
CF3
H
Br
O
CH2
O
CH2CHF2


P1985
H
Br
H
Br
CF3
H
Cl
O
CH2
O
CH2CHF2


P1986
H
Br
H
Br
CF3
H
CF3
O
CH2
O
CH2CHF2


P1987
H
Br
H
Br
CF3
H
CH3
O
CH2
O
CH2CHF2


P1988
H
Br
H
Br
CF3
H
H
O
CH2
O
CH2CH2F


P1989
H
Br
H
Br
CF3
H
Br
O
CH2
O
CH2CH2F


P1990
H
Br
H
Br
CF3
H
Cl
O
CH2
O
CH2CH2F


P1991
H
Br
H
Br
CF3
H
CF3
O
CH2
O
CH2CH2F


P1992
H
Br
H
Br
CF3
H
CH3
O
CH2
O
CH2CH2F


P1993
H
Br
H
Br
CF3
H
H
O
CH2
O
CH2CH3


P1994
H
Br
H
Br
CF3
H
Br
O
CH2
O
CH2CH3


P1995
H
Br
H
Br
CF3
H
Cl
O
CH2
O
CH2CH3


P1996
H
Br
H
Br
CF3
H
CF3
O
CH2
O
CH2CH3


P1997
H
Br
H
Br
CF3
H
CH3
O
CH2
O
CH2CH3


P1998
H
Br
H
Br
CF3
CF3
H
O
CH2
O
CH2CF3


P1999
H
Br
H
Br
CF3
CF3
Br
O
CH2
O
CH2CF3


P2000
H
Br
H
Br
CF3
CF3
Cl
O
CH2
O
CH2CF3


P2001
H
Br
H
Br
CF3
CF3
CF3
O
CH2
O
CH2CF3


P2002
H
Br
H
Br
CF3
CF3
CH3
O
CH2
O
CH2CF3


P2003
H
Br
H
Br
CF2CF3
H
H
O
CH2
O
CH2CF3


P2004
H
Br
H
Br
CF2CF3
H
Br
O
CH2
O
CH2CF3


P2005
H
Br
H
Br
CF2CF3
H
Cl
O
CH2
O
CH2CF3


P2006
H
Br
H
Br
CF2CF3
H
CF3
O
CH2
O
CH2CF3


P2007
H
Br
H
Br
CF2CF3
H
CH3
O
CH2
O
CH2CF3


P2008
H
Br
H
Br
CF3
H
H
O
CH2
O
CH(CH3)CF3


P2009
H
Br
H
Br
CF3
H
Br
O
CH2
O
CH(CH3)CF3


P2010
H
Br
H
Br
CF3
H
Cl
O
CH2
O
CH(CH3)CF3


P2011
H
Br
H
Br
CF3
H
CF3
O
CH2
O
CH(CH3)CF3


P2012
H
Br
H
Br
CF3
H
CH3
O
CH2
O
CH(CH3)CF3


P2013
H
Br
H
Br
CF3
CF3
H
O
CH(CH3)
O
CH2CF3


P2014
H
Br
H
Br
CF3
CF3
Br
O
CH(CH3)
O
CH2CF3


P2015
H
Br
H
Br
CF3
CF3
Cl
O
CH (CH3)
O
CH2CF3


P2016
H
Br
H
Br
CF3
CF3
CF3
O
CH(CH3)
O
CH2CF3


P2017
H
Br
H
Br
CF3
CF3
CH3
O
CH (CH3)
O
CH2CF3


P2018
H
Br
H
Br
CF2CF3
H
H
O
CH (CH3)
O
CH2CF3


P2019
H
Br
H
Br
CF2CF3
H
Br
O
CH (CH3)
O
CH2CF3


P2020
H
Br
H
Br
CF2CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P2021
H
Br
H
Br
CF2CF3
H
CF3
O
CH (CH3)
O
CH2CF3


P2022
H
Br
H
Br
CF2CF3
H
CH3
O
CH (CH3)
O
CH2CF3


P2023
H
Br
H
Br
CF3
H
H
O
CH(CH3)
O
CH2CF3


P2024
H
Br
H
Br
CF3
H
Cl
O
CH (CH3)
O
CH2CF3


P2025
H
Br
H
Br
CF3
H
H
O
CH(CH3)
S
CH2CF3


P2026
H
Br
H
Br
CF3
H
Br
O
CH(CH3)
S
CH2CF3


P2027
H
Br
H
Br
CF3
H
Cl
O
CH (CH3)
S
CH2CF3


P2028
H
Br
H
Br
CF3
H
CF3
O
CH(CH3)
S
CH2CF3


P2029
H
Br
H
Br
CF3
H
CH3
O
CH (CH3)
S
CH2CF3


P2030
H
Br
H
Br
CF3
H
H
S
CH(CH3)
O
CH2CF3


P2031
H
Br
H
Br
CF3
H
Br
S
CH(CH3)
O
CH2CF3


P2032
H
Br
H
Br
CF3
H
Cl
S
CH (CH3)
O
CH2CF3


P2033
H
Br
H
Br
CF3
H
CF3
S
CH(CH3)
O
CH2CF3


P2034
H
Br
H
Br
CF3
H
CH3
S
CH (CH3)
O
CH2CF3


P2035
H
Br
H
Br
CF3
H
H
O
CH(CH3)
O
CH2CHF2


P2036
H
Br
H
Br
CF3
H
Br
O
CH(CH3)
O
CH2CHF2


P2037
H
Br
H
Br
CF3
H
Cl
O
CH (CH3)
O
CH2CHF2


P2038
H
Br
H
Br
CF3
H
CF3
O
CH(CH3)
O
CH2CHF2


P2039
H
Br
H
Br
CF3
H
CH3
O
CH (CH3)
O
CH2CHF2


P2040
H
Br
H
Br
CF3
H
H
O
CH(CH3)
O
CH2CH2F


P2041
H
Br
H
Br
CF3
H
Br
O
CH(CH3)
O
CH2CH2F


P2042
H
Br
H
Br
CF3
H
Cl
O
CH(CH3)
O
CH2CH2F


P2043
H
Br
H
Br
CF3
H
CF3
O
CH(CH3)
O
CH2CH2F


P2044
H
Br
H
Br
CF3
H
CH3
O
CH(CH3)
O
CH2CH2F


P2045
H
Br
H
Br
CF3
H
H
O
CH(CH3)
O
CH2CH3


P2046
H
Br
H
Br
CF3
H
Br
O
CH(CH3)
O
CH2CH3


P2047
H
Br
H
Br
CF3
H
Cl
O
CH(CH3)
O
CH2CH3


P2048
H
Br
H
Br
CF3
H
CF3
O
CH(CH3)
O
CH2CH3


P2049
H
Br
H
Br
CF3
H
CH3
O
CH(CH3)
O
CH2CH3


P2050
H
Br
H
Br
CF3
H
H
O
CH(CH3)
O
CH(CH3)CF3


P2051
H
Br
H
Br
CF3
H
Br
O
CH(CH3)
O
CH(CH3)CF3


P2052
H
Br
H
Br
CF3
H
Cl
O
CH (CH3)
O
CH(CH3)CF3


P2053
H
Br
H
Br
CF3
H
CF3
O
CH(CH3)
O
CH(CH3)CF3


P2054
H
Br
H
Br
CF3
H
CH3
O
CH (CH3)
O
CH(CH3)CF3


P2055
H
Br
H
Br
CF3
H
H
O
CH(CH3)
O
CH2CH2CF3


P2056
H
Br
H
Br
CF3
H
Br
O
CH(CH3)
O
CH2CH2CF3


P2057
H
Br
H
Br
CF3
H
Cl
O
CH (CH3)
O
CH2CH2CF3


P2058
H
Br
H
Br
CF3
H
CF3
O
CH(CH3)
O
CH2CH2CF3


P2059
H
Br
H
Br
CF3
H
CH3
O
CH (CH3)
O
CH2CH2CF3


P2060
H
Br
H
Br
CF3
H
H
O
CH(CH2CH3)
O
CH2CF3


P2061
H
Br
H
Br
CF3
H
Br
O
CH(CH2CH3)
O
CH2CF3


P2062
H
Br
H
Br
CF3
H
Cl
O
CH(CH2CH3)
O
CH2CF3


P2063
H
Br
H
Br
CF3
H
CF3
O
CH(CH2CH3)
O
CH2CF3


P2064
H
Br
H
Br
CF3
H
CH3
O
CH(CH2CH3)
O
CH2CF3


P2065
H
Br
H
Br
CF3
H
H
O
C(CH3)2
O
CH2CF3


P2066
H
Br
H
Br
CF3
H
Br
O
C(CH3)2
O
CH2CF3


P2067
H
Br
H
Br
CF3
H
Cl
O
C(CH3)2
O
CH2CF3


P2068
H
Br
H
Br
CF3
H
CF3
O
C(CH3)2
O
CH2CF3


P2069
H
Br
H
Br
CF3
H
CH3
O
C(CH3)2
O
CH2CF3


P2070
H
Br
H
Br
CF3
H
H
O
CH2CH2
O
CH2CF3


P2071
H
Br
H
Br
CF3
H
Br
O
CH2CH2
O
CH2CF3


P2072
H
Br
H
Br
CF3
H
Cl
O
CH2CH2
O
CH2CF3


P2073
H
Br
H
Br
CF3
H
CF3
O
CH2CH2
O
CH2CF3


P2074
H
Br
H
Br
CF3
H
CH3
O
CH2CH2
O
CH2CF3









Example A
Bioassays on Beet Armyworm (“Baw”) and Corn Earworm (“CEW”) and Cabbage Looper (“CL”)
BAW has few effective parasites, diseases, or predators to lower its population. BAW infests many weeds, trees, grasses, legumes, and field crops. In various places, it is of economic concern upon asparagus, cotton, corn, soybeans, tobacco, alfalfa, sugar beets, peppers, tomatoes, potatoes, onions, peas, sunflowers, and citrus, among other plants. CEW is known to attack corn and tomatoes, but it also attacks artichoke, asparagus, cabbage, cantaloupe, collards, cowpeas, cucumbers, eggplant, lettuce, lima beans, melon, okra, peas, peppers, potatoes, pumpkin, snap beans, spinach, squash, sweet potatoes, and watermelon, among other plants. CEW is also known to be resistant to certain insecticides. CL is also known to be resistant to certain insecticides. Consequently, because of the above factors control of these pests is important. Furthermore, molecules that control these pests are useful in controlling other pests.
Certain molecules disclosed in this document were tested against BAW, CEW and CL using procedures described in the following examples. In the reporting of the results, the “BAW & CEW & CL Rating Table” was used (See Table Section).
Bioassays on BAW (spodoptera exigua)
Bioassays on BAW were conducted using a 128-well diet tray assay. One to five second instar BAW larvae were placed in each well (3 mL) of the diet tray that had been previously filled with 1 mL of artificial diet to which 50 μg/cm2 of the test compound (dissolved in 50 μL of 90:10 acetone-water mixture) had been applied (to each of eight wells) and then allowed to dry. Trays were covered with a clear self-adhesive cover, and held at 25° C., 14:10 light-dark for five to seven days. Percent mortality was recorded for the larvae in each well; activity in the eight wells was then averaged. The results are indicated in the tables entitled “Table 3: Assay Results Part 1” and “Table 4: Assay Results Part 2” (See Table Section).
Bioassays on CEW (Helicoverpa zea)
Bioassays on CEW were conducted using a 128-well diet tray assay. One to five second instar CEW larvae were placed in each well (3 mL) of the diet tray that had been previously filled with 1 mL of artificial diet to which 50 μg/cm2 of the test compound (dissolved in 50 μL of 90:10 acetone-water mixture) had been applied (to each of eight wells) and then allowed to dry. Trays were covered with a clear self-adhesive cover, and held at 25° C., 14:10 light-dark for five to seven days. Percent mortality was recorded for the larvae in each well; activity in the eight wells was then averaged. The results are indicated in the table entitled “Table 3: Assay Results Part 1” (See Table Section).
Bioassays on CL (Trichoplusia ni)
Bioassays on CL were conducted using a 128-well diet tray assay. One to five second instar CL larvae were placed in each well (3 mL) of the diet tray that had been previously filled with 1 mL of artificial diet to which 50 μg/cm2 of the test compound (dissolved in 50 μL of 90:10 acetone-water mixture) had been applied (to each of eight wells) and then allowed to dry. Trays were covered with a clear self-adhesive cover, and held at 25° C., 14:10 light-dark for five to seven days. Percent mortality was recorded for the larvae in each well; activity in the eight wells was then averaged. The results are indicated in the table entitled “Table 4: Assay Results Part 2” (See Table Section).
Example B
Bioassays on green peach aphid (“GPA”) (Myzus persicae)
GPA is the most significant aphid pest of peach trees, causing decreased growth, shriveling of the leaves, and the death of various tissues. It is also hazardous because it acts as a vector for the transport of plant viruses, such as potato virus Y and potato leafroll virus to members of the nightshade/potato family Solanaceae, and various mosaic viruses to many other food crops. GPA attacks such plants as broccoli, burdock, cabbage, carrot, cauliflower, daikon, eggplant, green beans, lettuce, macadamia, papaya, peppers, sweet potatoes, tomatoes, watercress, and zucchini, among other plants. GPA also attacks many ornamental crops such as carnation, chrysanthemum, flowering white cabbage, poinsettia, and roses. GPA has developed resistance to many pesticides.
Certain molecules disclosed in this document were tested against GPA using procedures described in the following example. In the reporting of the results, the “GPA Rating Table” was used (See Table Section).
Cabbage seedlings grown in 3-inch pots, with 2-3 small (3-5 cm) true leaves, were used as test substrate. The seedlings were infested with 20-50 GPA (wingless adult and nymph stages) one day prior to chemical application. Four pots with individual seedlings were used for each treatment. Test compounds (2 mg) were dissolved in 2 mL of acetone/MeOH (1:1) solvent, forming stock solutions of 1000 ppm test compound. The stock solutions were diluted 5× with 0.025% Tween 20 in water to obtain the solution at 200 ppm test compound. A hand-held aspirator-type sprayer was used for spraying a solution to both sides of cabbage leaves until runoff. Reference plants (solvent check) were sprayed with the diluent only containing 20% by volume of acetone/MeOH (1:1) solvent. Treated plants were held in a holding room for three days at approximately 25° C. and ambient relative humidity (RH) prior to grading. Evaluation was conducted by counting the number of live aphids per plant under a microscope. Percent Control was measured by using Abbott's correction formula (W. S. Abbott, “A Method of Computing the Effectiveness of an Insecticide” J. Econ. Entomol. 18 (1925), pp. 265-267) as follows.

Corrected % Control=100*(X−Y)/X 

    
    
        where
        X=No. of live aphids on solvent check plants and
        Y=No. of live aphids on treated plants
    
    


The results are indicated in the tables entitled “Table 3: Assay Results Part 1” and “Table 4: Assay Results Part 2” (See Table Section).
Pesticidally Acceptable Acid Addition Salts, Salt Derivatives, Solvates, Ester Derivatives, Polymorphs, Isotopes and Radionuclides
Molecules of Formula One may be formulated into pesticidally acceptable acid addition salts. By way of a non-limiting example, an amine function can form salts with hydrochloric, hydrobromic, sulfuric, phosphoric, acetic, benzoic, citric, malonic, salicylic, malic, fumaric, oxalic, succinic, tartaric, lactic, gluconic, ascorbic, maleic, aspartic, benzenesulfonic, methanesulfonic, ethanesulfonic, hydroxymethanesulfonic, and hydroxyethanesulfonic acids. Additionally, by way of a non-limiting example, an acid function can form salts including those derived from alkali or alkaline earth metals and those derived from ammonia and amines. Examples of preferred cations include sodium, potassium, and magnesium.
Molecules of Formula One may be formulated into salt derivatives. By way of a non-limiting example, a salt derivative can be prepared by contacting a free base with a sufficient amount of the desired acid to produce a salt. A free base may be regenerated by treating the salt with a suitable dilute aqueous base solution such as dilute aqueous NaOH, potassium carbonate, ammonia, and sodium bicarbonate. As an example, in many cases, a pesticide, such as 2,4-D, is made more water-soluble by converting it to its dimethylamine salt.
Molecules of Formula One may be formulated into stable complexes with a solvent, such that the complex remains intact after the non-complexed solvent is removed. These complexes are often referred to as “solvates.” However, it is particularly desirable to form stable hydrates with water as the solvent.
Molecules of Formula One may be made into ester derivatives. These ester derivatives can then be applied in the same manner as the invention disclosed in this document is applied.
Molecules of Formula One may be made as various crystal polymorphs. Polymorphism is important in the development of agrochemicals since different crystal polymorphs or structures of the same molecule can have vastly different physical properties and biological performances.
Molecules of Formula One may be made with different isotopes. Of particular importance are molecules having 2H (also known as deuterium) in place of 1H.
Molecules of Formula One may be made with different radionuclides. Of particular importance are molecules having 14C.
Stereoisomers
Molecules of Formula One may exist as one or more stereoisomers. Thus, certain molecules can be produced as racemic mixtures. It will be appreciated by those skilled in the art that one stereoisomer may be more active than the other stereoisomers. Individual stereoisomers may be obtained by known selective synthetic procedures, by conventional synthetic procedures using resolved starting materials, or by conventional resolution procedures. Certain molecules disclosed in this document can exist as two or more isomers. The various isomers include geometric isomers, diastereomers, and enantiomers. Thus, the molecules disclosed in this document include geometric isomers, racemic mixtures, individual stereoisomers, and optically active mixtures. It will be appreciated by those skilled in the art that one isomer may be more active than the others. The structures disclosed in the present disclosure are drawn in only one geometric form for clarity, but are intended to represent all geometric forms of the molecule.
Combinations
Molecules of Formula One may also be used in combination (such as, in a compositional mixture, or a simultaneous or sequential application) with one or more compounds having acaricidal, algicidal, avicidal, bactericidal, fungicidal, herbicidal, insecticidal, molluscicidal, nematicidal, rodenticidal, or virucidal properties. Additionally, the molecules of Formula One may also be used in combination (such as, in a compositional mixture, or a simultaneous or sequential application) with compounds that are antifeedants, bird repellents, chemosterilants, herbicide safeners, insect attractants, insect repellents, mammal repellents, mating disrupters, plant activators, plant growth regulators, or synergists. Examples of such compounds in the above groups that may be used with the Molecules of Formula One are—(3-ethoxypropyl)mercury bromide, 1,2-dichloropropane, 1,3-dichloropropene, 1-methylcyclopropene, 1-naphthol, 2-(octylthio)ethanol, 2,3,5-tri-iodobenzoic acid, 2,3,6-TBA, 2,3,6-TBA-dimethylammonium, 2,3,6-TBA-lithium, 2,3,6-TBA-potassium, 2,3,6-TBA-sodium, 2,4,5-T, 2,4,5-T-2-butoxypropyl, 2,4,5-T-2-ethylhexyl, 2,4,5-T-3-butoxypropyl, 2,4,5-TB, 2,4,5-T-butomethyl, 2,4,5-T-butotyl, 2,4,5-T-butyl, 2,4,5-T-isobutyl, 2,4,5-T-isoctyl, 2,4,5-T-isopropyl, 2,4,5-T-methyl, 2,4,5-T-pentyl, 2,4,5-T-sodium, 2,4,5-T-triethylammonium, 2,4,5-T-trolamine, 2,4-D, 2,4-D-2-butoxypropyl, 2,4-D-2-ethylhexyl, 2,4-D-3-butoxypropyl, 2,4-D-ammonium, 2,4-DB, 2,4-DB-butyl, 2,4-DB-dimethylammonium, 2,4-DB-isoctyl, 2,4-DB-potassium, 2,4-DB-sodium, 2,4-D-butotyl, 2,4-D-butyl, 2,4-D-diethylammonium, 2,4-D-dimethylammonium, 2,4-D-diolamine, 2,4-D-dodecylammonium, 2,4-DEB, 2,4-DEP, 2,4-D-ethyl, 2,4-D-heptylammonium, 2,4-D-isobutyl, 2,4-D-isoctyl, 2,4-D-isopropyl, 2,4-D-isopropylammonium, 2,4-D-lithium, 2,4-D-meptyl, 2,4-D-methyl, 2,4-D-octyl, 2,4-D-pentyl, 2,4-D-potassium, 2,4-D-propyl, 2,4-D-sodium, 2,4-D-tefuryl, 2,4-D-tetradecylammonium, 2,4-D-triethylammonium, 2,4-D-tris(2-hydroxypropyl)ammonium, 2,4-D-trolamine, 2iP, 2-methoxyethylmercury chloride, 2-phenylphenol, 3,4-DA, 3,4-DB, 3,4-DP, 4-aminopyridine, 4-CPA, 4-CPA-potassium, 4-CPA-sodium, 4-CPB, 4-CPP, 4-hydroxyphenethyl alcohol, 8-hydroxyquinoline sulfate, 8-phenylmercurioxyquinoline, abamectin, abscisic acid, ACC, acephate, acequinocyl, acetamiprid, acethion, acetochlor, acetophos, acetoprole, acibenzolar, acibenzolar-5-methyl, acifluorfen, acifluorfen-methyl, acifluorfen-sodium, aclonifen, acrep, acrinathrin, acrolein, acrylonitrile, acypetacs, acypetacs-copper, acypetacs-zinc, alachlor, alanycarb, albendazole, aldicarb, aldimorph, aldoxycarb, aldrin, allethrin, allicin, allidochlor, allosamidin, alloxydim, alloxydim-sodium, allyl alcohol, allyxycarb, alorac, alpha-cypermethrin, alpha-endosulfan, ametoctradin, ametridione, ametryn, amibuzin, amicarbazone, amicarthiazol, amidithion, amidoflumet, amidosulfuron, aminocarb, aminocyclopyrachlor, aminocyclopyrachlor-methyl, aminocyclopyrachlor-potassium, aminopyralid, aminopyralid-potassium, aminopyralid-tris(2-hydroxypropyl)ammonium, amiprofos-methyl, amiprophos, amisulbrom, amiton, amiton oxalate, amitraz, amitrole, ammonium sulfamate, ammonium α-naphthaleneacetate, amobam, ampropylfos, anabasine, ancymidol, anilazine, anilofos, anisuron, anthraquinone, antu, apholate, aramite, arsenous oxide, asomate, aspirin, asulam, asulam-potassium, asulam-sodium, athidathion, atraton, atrazine, aureofungin, aviglycine, aviglycine hydrochloride, azaconazole, azadirachtin, azafenidin, azamethiphos, azimsulfuron, azinphos-ethyl, azinphos-methyl, aziprotryne, azithiram, azobenzene, azocyclotin, azothoate, azoxystrobin, bachmedesh, barban, barium hexafluorosilicate, barium polysulfide, barthrin, BCPC, beflubutamid, benalaxyl, benalaxyl-M, benazolin, benazolin-dimethylammonium, benazolin-ethyl, benazolin-potassium, bencarbazone, benclothiaz, bendiocarb, benfluralin, benfuracarb, benfuresate, benodanil, benomyl, benoxacor, benoxafos, benquinox, bensulfuron, bensulfuron-methyl, bensulide, bensultap, bentaluron, bentazone, bentazone-sodium, benthiavalicarb, benthiavalicarb-isopropyl, benthiazole, bentranil, benzadox, benzadox-ammonium, benzalkonium chloride, benzamacril, benzamacril-isobutyl, benzamorf, benzfendizone, benzipram, benzobicyclon, benzofenap, benzofluor, benzohydroxamic acid, benzoximate, benzoylprop, benzoylprop-ethyl, benzthiazuron, benzyl benzoate, benzyladenine, berberine, berberine chloride, beta-cyfluthrin, beta-cypermethrin, bethoxazin, bicyclopyrone, bifenazate, bifenox, bifenthrin, bifujunzhi, bilanafos, bilanafos-sodium, binapacryl, bingqingxiao, bioallethrin, bioethanomethrin, biopermethrin, bioresmethrin, biphenyl, bisazir, bismerthiazol, bispyribac, bispyribac-sodium, bistrifluoron, bitertanol, bithionol, bixafen, blasticidin-S, borax, Bordeaux mixture, boric acid, boscalid, brassinolide, brassinolide-ethyl, brevicomin, brodifacoum, brofenvalerate, brofluthrinate, bromacil, bromacil-lithium, bromacil-sodium, bromadiolone, bromethalin, bromethrin, bromfenvinfos, bromoacetamide, bromobonil, bromobutide, bromocyclen, bromo-DDT, bromofenoxim, bromophos, bromophos-ethyl, bromopropylate, bromothalonil, bromoxynil, bromoxynil butyrate, bromoxynil heptanoate, bromoxynil octanoate, bromoxynil-potassium, brompyrazon, bromuconazole, bronopol, bucarpolate, bufencarb, buminafos, bupirimate, buprofezin, Burgundy mixture, busulfan, butacarb, butachlor, butafenacil, butamifos, butathiofos, butenachlor, butethrin, buthidazole, buthiobate, buthiuron, butocarboxim, butonate, butopyronoxyl, butoxycarboxim, butralin, butroxydim, buturon, butylamine, butylate, cacodylic acid, cadusafos, cafenstrole, calcium arsenate, calcium chlorate, calcium cyanamide, calcium polysulfide, calvinphos, cambendichlor, camphechlor, camphor, captafol, captan, carbamorph, carbanolate, carbaryl, carbasulam, carbendazim, carbendazim benzenesulfonate, carbendazim sulfite, carbetamide, carbofuran, carbon disulfide, carbon tetrachloride, carbophenothion, carbosulfan, carboxazole, carboxide, carboxin, carfentrazone, carfentrazone-ethyl, carpropamid, cartap, cartap hydrochloride, carvacrol, carvone, CDEA, cellocidin, CEPC, ceralure, Cheshunt mixture, chinomethionat, chitosan, chlobenthiazone, chlomethoxyfen, chloralose, chloramben, chloramben-ammonium, chloramben-diolamine, chloramben-methyl, chloramben-methylammonium, chloramben-sodium, chloramine phosphorus, chloramphenicol, chloraniformethan, chloranil, chloranocryl, chlorantraniliprole, chlorazifop, chlorazifop-propargyl, chlorazine, chlorbenside, chlorbenzuron, chlorbicyclen, chlorbromuron, chlorbufam, chlordane, chlordecone, chlordimeform, chlordimeform hydrochloride, chlorempenthrin, chlorethoxyfos, chloreturon, chlorfenac, chlorfenac-ammonium, chlorfenac-sodium, chlorfenapyr, chlorfenazole, chlorfenethol, chlorfenprop, chlorfenson, chlorfensulphide, chlorfenvinphos, chlorfluazuron, chlorflurazole, chlorfluren, chlorfluren-methyl, chlorflurenol, chlorflurenol-methyl, chloridazon, chlorimuron, chlorimuron-ethyl, chlormephos, chlormequat, chlormequat chloride, chlomidine, chlornitrofen, chlorobenzilate, chlorodinitronaphthalenes, chloroform, chloromebuform, chloromethiuron, chloroneb, chlorophacinone, chlorophacinone-sodium, chloropicrin, chloropon, chloropropylate, chlorothalonil, chlorotoluron, chloroxuron, chloroxynil, chlorphonium, chlorphonium chloride, chlorphoxim, chlorprazophos, chlorprocarb, chlorpropham, chlorpyrifos, chlorpyrifos-methyl, chlorquinox, chlorsulfuron, chlorthal, chlorthal-dimethyl, chlorthal-monomethyl, chlorthiamid, chlorthiophos, chlozolinate, choline chloride, chromafenozide, cinerin I, cinerin II, cinerins, cinidon-ethyl, cinmethylin, cinosulfuron, ciobutide, cisanilide, cismethrin, clethodim, climbazole, cliodinate, clodinafop, clodinafop-propargyl, cloethocarb, clofencet, clofencet-potassium, clofentezine, clofibric acid, clofop, clofop-isobutyl, clomazone, clomeprop, cloprop, cloproxydim, clopyralid, clopyralid-methyl, clopyralid-olamine, clopyralid-potassium, clopyralid-tris(2-hydroxypropyl)ammonium, cloquintocet, cloquintocet-mexyl, cloransulam, cloransulam-methyl, closantel, clothianidin, clotrimazole, cloxyfonac, cloxyfonac-sodium, CMA, codlelure, colophonate, copper acetate, copper acetoarsenite, copper arsenate, copper carbonate, basic, copper hydroxide, copper naphthenate, copper oleate, copper oxychloride, copper silicate, copper sulfate, copper zinc chromate, coumachlor, coumafuryl, coumaphos, coumatetralyl, coumithoate, coumoxystrobin, CPMC, CPMF, CPPC, credazine, cresol, crimidine, crotamiton, crotoxyphos, crufomate, cryolite, cue-lure, cufraneb, cumyluron, cuprobam, cuprous oxide, curcumenol, cyanamide, cyanatryn, cyanazine, cyanofenphos, cyanophos, cyanthoate, cyantraniliprole, cyazofamid, cybutryne, cyclafuramid, cyclanilide, cyclethrin, cycloate, cycloheximide, cycloprate, cycloprothrin, cyclosulfamuron, cycloxaprid, cycloxydim, cycluron, cyenopyrafen, cyflufenamid, cyflumetofen, cyfluthrin, cyhalofop, cyhalofop-butyl, cyhalothrin, cyhexatin, cymiazole, cymiazole hydrochloride, cymoxanil, cyometrinil, cypendazole, cypermethrin, cyperquat, cyperquat chloride, cyphenothrin, cyprazine, cyprazole, cyproconazole, cyprodinil, cyprofuram, cypromid, cyprosulfamide, cyromazine, cythioate, daimuron, dalapon, dalapon-calcium, dalapon-magnesium, dalapon-sodium, daminozide, dayoutong, dazomet, dazomet-sodium, DB CP, d-camphor, DCIP, DCPTA, DDT, debacarb, decafentin, decarbofuran, dehydroacetic acid, delachlor, deltamethrin, demephion, demephion-O, demephion-S, demeton, demeton-methyl, demeton-O, demeton-O-methyl, demeton-S, demeton-S-methyl, demeton-S-methylsulphon, desmedipham, desmetryn, d-fanshiluquebingjuzhi, diafenthiuron, dialifos, di-allate, diamidafos, diatomaceous earth, diazinon, dibutyl phthalate, dibutyl succinate, dicamba, dicamba-diglycolamine, dicamba-dimethylammonium, dicamba-diolamine, dicamba-isopropylammonium, dicamba-methyl, dicamba-olamine, dicamba-potassium, dicamba-sodium, dicamba-trolamine, dicapthon, dichlobenil, dichlofenthion, dichlofluanid, dichlone, dichloralurea, dichlorbenzuron, dichlorflurenol, dichlorflurenol-methyl, dichlormate, dichlormid, dichlorophen, dichlorprop, dichlorprop-2-ethylhexyl, dichlorprop-butotyl, dichlorprop-dimethylammonium, dichlorprop-ethylammonium, dichlorprop-isoctyl, dichlorprop-methyl, dichlorprop-P, dichlorprop-P-2-ethylhexyl, dichlorprop-P-dimethylammonium, dichlorprop-potassium, dichlorprop-sodium, dichlorvos, dichlozoline, diclobutrazol, diclocymet, diclofop, diclofop-methyl, diclomezine, diclomezine-sodium, dicloran, diclosulam, dicofol, dicoumarol, dicresyl, dicrotophos, dicyclanil, dicyclonon, dieldrin, dienochlor, diethamquat, diethamquat dichloride, diethatyl, diethatyl-ethyl, diethofencarb, dietholate, diethyl pyrocarbonate, diethyltoluamide, difenacoum, difenoconazole, difenopenten, difenopenten-ethyl, difenoxuron, difenzoquat, difenzoquat metilsulfate, difethialone, diflovidazin, diflubenzuron, diflufenican, diflufenzopyr, diflufenzopyr-sodium, diflumetorim, dikegulac, dikegulac-sodium, dilor, dimatif, dimefluthrin, dimefox, dimefuron, dimepiperate, dimetachlone, dimetan, dimethacarb, dimethachlor, dimethametryn, dimethenamid, dimethenamid-P, dimethipin, dimethirimol, dimethoate, dimethomorph, dimethrin, dimethyl carbate, dimethyl phthalate, dimethylvinphos, dimetilan, dimexano, dimidazon, dimoxystrobin, dinex, dinex-diclexine, dingjunezuo, diniconazole, diniconazole-M, dinitramine, dinobuton, dinocap, dinocap-4, dinocap-6, dinocton, dinofenate, dinopenton, dinoprop, dinosam, dinoseb, dinoseb acetate, dinoseb-ammonium, dinoseb-diolamine, dinoseb-sodium, dinoseb-trolamine, dinosulfon, dinotefuran, dinoterb, dinoterb acetate, dinoterbon, diofenolan, dioxabenzofos, dioxacarb, dioxathion, diphacinone, diphacinone-sodium, diphenamid, diphenyl sulfone, diphenylamine, dipropalin, dipropetryn, dipyrithione, diquat, diquat dibromide, disparlure, disul, disulfuram, disulfoton, disul-sodium, ditalimfos, dithianon, dithicrofos, dithioether, dithiopyr, diuron, d-limonene, DMPA, DNOC, DNOC-ammonium, DNOC-potassium, DNOC-sodium, dodemorph, dodemorph acetate, dodemorph benzoate, dodicin, dodicin hydrochloride, dodicin-sodium, dodine, dofenapyn, dominicalure, doramectin, drazoxolon, DSMA, dufulin, EBEP, EBP, ecdysterone, edifenphos, eglinazine, eglinazine-ethyl, emamectin, emamectin benzoate, EMPC, empenthrin, endosulfan, endothal, endothal-diammonium, endothal-dipotassium, endothal-disodium, endothion, endrin, enestroburin, EPN, epocholeone, epofenonane, epoxiconazole, eprinomectin, epronaz, EPTC, erbon, ergocalciferol, erlujixiancaoan, esdépalléthrine, esfenvalerate, esprocarb, etacelasil, etaconazole, etaphos, etem, ethaboxam, ethachlor, ethalfluralin, ethametsulfuron, ethametsulfuron-methyl, ethaprochlor, ethephon, ethidimuron, ethiofencarb, ethiolate, ethion, ethiozin, ethiprole, ethirimol, ethoate-methyl, ethofumesate, ethohexadiol, ethoprophos, ethoxyfen, ethoxyfen-ethyl, ethoxyquin, ethoxysulfuron, ethychlozate, ethyl formate, ethyl α-naphthaleneacetate, ethyl-DDD, ethylene, ethylene dibromide, ethylene dichloride, ethylene oxide, ethylicin, ethylmercury 2,3-dihydroxypropyl mercaptide, ethylmercury acetate, ethylmercury bromide, ethylmercury chloride, ethylmercury phosphate, etinofen, etnipromid, etobenzanid, etofenprox, etoxazole, etridiazole, etrimfos, eugenol, EXD, famoxadone, famphur, fenamidone, fenaminosulf, fenamiphos, fenapanil, fenarimol, fenasulam, fenazaflor, fenazaquin, fenbuconazole, fenbutatin oxide, fenchlorazole, fenchlorazole-ethyl, fenchlorphos, fenclorim, fenethacarb, fenfluthrin, fenfuram, fenhexamid, fenitropan, fenitrothion, fenjuntong, fenobucarb, fenoprop, fenoprop-3-butoxypropyl, fenoprop-butomethyl, fenoprop-butotyl, fenoprop-butyl, fenoprop-isoctyl, fenoprop-methyl, fenoprop-potassium, fenothiocarb, fenoxacrim, fenoxanil, fenoxaprop, fenoxaprop-ethyl, fenoxaprop-P, fenoxaprop-P-ethyl, fenoxasulfone, fenoxycarb, fenpiclonil, fenpirithrin, fenpropathrin, fenpropidin, fenpropimorph, fenpyrazamine, fenpyroximate, fenridazon, fenridazon-potassium, fenridazon-propyl, fenson, fensulfothion, fenteracol, fenthiaprop, fenthiaprop-ethyl, fenthion, fenthion-ethyl, fentin, fentin acetate, fentin chloride, fentin hydroxide, fentrazamide, fentrifanil, fenuron, fenuron TCA, fenvalerate, ferbam, ferimzone, ferrous sulfate, fipronil, flamprop, flamprop-isopropyl, flamprop-M, flamprop-methyl, flamprop-M-isopropyl, flamprop-M-methyl, flazasulfuron, flocoumafen, flometoquin, flonicamid, florasulam, fluacrypyrim, fluazifop, fluazifop-butyl, fluazifop-methyl, fluazifop-P, fluazifop-P-butyl, fluazinam, fluazolate, fluazuron, flubendiamide, flubenzimine, flucarbazone, flucarbazone-sodium, flucetosulfuron, fluchloralin, flucofuron, flucycloxuron, flucythrinate, fludioxonil, fluenetil, fluensulfone, flufenacet, flufenerim, flufenican, flufenoxuron, flufenprox, flufenpyr, flufenpyr-ethyl, flufiprole, flumethrin, flumetover, flumetralin, flumetsulam, flumezin, flumiclorac, flumiclorac-pentyl, flumioxazin, flumipropyn, flumorph, fluometuron, fluopicolide, fluopyram, fluorbenside, fluoridamid, fluoroacetamide, fluorodifen, fluoroglycofen, fluoroglycofen-ethyl, fluoroimide, fluoromidine, fluoronitrofen, fluothiuron, fluotrimazole, fluoxastrobin, flupoxam, flupropacil, flupropadine, flupropanate, flupropanate-sodium, flupyradifurone, flupyrsulfuron, flupyrsulfuron-methyl, flupyrsulfuron-methyl-sodium, fluquinconazole, flurazole, flurenol, flurenol-butyl, flurenol-methyl, fluridone, fluorochloridone, fluoroxypyr, fluoroxypyr-butomethyl, fluoroxypyr-meptyl, flurprimidol, flursulamid, flurtamone, flusilazole, flusulfamide, fluthiacet, fluthiacet-methyl, flutianil, flutolanil, flutriafol, fluvalinate, fluxapyroxad, fluxofenim, folpet, fomesafen, fomesafen-sodium, fonofos, foramsulfuron, forchlorfenuron, formaldehyde, formetanate, formetanate hydrochloride, formothion, formparanate, formparanate hydrochloride, fosamine, fosamine-ammonium, fosetyl, fosetyl-aluminium, fosmethilan, fospirate, fosthiazate, fosthietan, frontalin, fuberidazole, fucaojing, fucaomi, funaihecaoling, fuphenthiourea, furalane, furalaxyl, furamethrin, furametpyr, furathiocarb, furcarbanil, furconazole, furconazole-cis, furethrin, furfural, furilazole, furmecyclox, furophanate, furyloxyfen, gamma-cyhalothrin, gamma-HCH, genit, gibberellic acid, gibberellins, gliftor, glufosinate, glufosinate-ammonium, glufosinate-P, glufosinate-P-ammonium, glufosinate-P-sodium, glyodin, glyoxime, glyphosate, glyphosate-diammonium, glyphosate-dimethylammonium, glyphosate-isopropylammonium, glyphosate-monoammonium, glyphosate-potassium, glyphosate-sesquisodium, glyphosate-trimesium, glyphosine, gossyplure, grandlure, griseofulvin, guazatine, guazatine acetates, halacrinate, halfenprox, halofenozide, halosafen, halosulfuron, halosulfuron-methyl, haloxydine, haloxyfop, haloxyfop-etotyl, haloxyfop-methyl, haloxyfop-P, haloxyfop-P-etotyl, haloxyfop-P-methyl, haloxyfop-sodium, HCH, hemel, hempa, HEOD, heptachlor, heptenophos, heptopargil, heterophos, hexachloroacetone, hexachlorobenzene, hexachlorobutadiene, hexachlorophene, hexaconazole, hexaflumuron, hexaflurate, hexylure, hexamide, hexazinone, hexylthiofos, hexythiazox, HHDN, holosulf, huancaiwo, huangcaoling, huanjunzuo, hydramethylnon, hydrargaphen, hydrated lime, hydrogen cyanide, hydroprene, hymexazol, hyquincarb, IAA, IBA, icaridin, imazalil, imazalil nitrate, imazalil sulfate, imazamethabenz, imazamethabenz-methyl, imazamox, imazamox-ammonium, imazapic, imazapic-ammonium, imazapyr, imazapyr-isopropylammonium, imazaquin, imazaquin-ammonium, imazaquin-methyl, imazaquin-sodium, imazethapyr, imazethapyr-ammonium, imazosulfuron, imibenconazole, imicyafos, imidacloprid, imidaclothiz, iminoctadine, iminoctadine triacetate, iminoctadine trialbesilate, imiprothrin, inabenfide, indanofan, indaziflam, indoxacarb, inezin, iodobonil, iodocarb, iodomethane, iodosulfuron, iodosulfuron-methyl, iodosulfuron-methyl-sodium, iofensulfuron, iofensulfuron-sodium, ioxynil, ioxynil octanoate, ioxynil-lithium, ioxynil-sodium, ipazine, ipconazole, ipfencarbazone, iprobenfos, iprodione, iprovalicarb, iprymidam, ipsdienol, ipsenol, IPSP, isamidofos, isazofos, isobenzan, isocarbamid, isocarbophos, isocil, isodrin, isofenphos, isofenphos-methyl, isolan, isomethiozin, isonoruron, isopolinate, isoprocarb, isopropalin, isoprothiolane, isoproturon, isopyrazam, isopyrimol, isothioate, isotianil, isouron, isovaledione, isoxaben, isoxachlortole, isoxadifen, isoxadifen-ethyl, isoxaflutole, isoxapyrifop, isoxathion, ivermectin, izopamfos, japonilure, japothrins, jasmolin I, jasmolin II, jasmonic acid, jiahuangchongzong, jiajizengxiaolin, jiaxiangjunzhi, jiecaowan, jiecaoxi, jodfenphos, juvenile hormone I, juvenile hormone II, juvenile hormone III, kadethrin, karbutilate, karetazan, karetazan-potassium, kasugamycin, kasugamycin hydrochloride, kejunlin, kelevan, ketospiradox, ketospiradox-potassium, kinetin, kinoprene, kresoxim-methyl, kuicaoxi, lactofen, lambda-cyhalothrin, latilure, lead arsenate, lenacil, lepimectin, leptophos, lindane, lineatin, linuron, lirimfos, litlure, looplure, lufenuron, lvdingjunzhi, lvxiancaolin, lythidathion, MAA, malathion, maleic hydrazide, malonoben, maltodextrin, MAMA, mancopper, mancozeb, mandipropamid, maneb, matrine, mazidox, MCPA, MCPA-2-ethylhexyl, MCPA-butotyl, MCPA-butyl, MCPA-dimethylammonium, MCPA-diolamine, MCPA-ethyl, MCPA-isobutyl, MCPA-isoctyl, MCPA-isopropyl, MCPA-methyl, MCPA-olamine, MCPA-potassium, MCPA-sodium, MCPA-thioethyl, MCPA-trolamine, MCPB, MCPB-ethyl, MCPB-methyl, MCPB-sodium, mebenil, mecarbam, mecarbinzid, mecarphon, mecoprop, mecoprop-2-ethylhexyl, mecoprop-dimethylammonium, mecoprop-diolamine, mecoprop-ethadyl, mecoprop-isoctyl, mecoprop-methyl, mecoprop-P, mecoprop-P-2-ethylhexyl, mecoprop-P-dimethylammonium, mecoprop-P-isobutyl, mecoprop-potassium, mecoprop-P-potassium, mecoprop-sodium, mecoprop-trolamine, medimeform, medinoterb, medinoterb acetate, medlure, mefenacet, mefenpyr, mefenpyr-diethyl, mefluidide, mefluidide-diolamine, mefluidide-potassium, megatomoic acid, menazon, mepanipyrim, meperfluthrin, mephenate, mephosfolan, mepiquat, mepiquat chloride, mepiquat pentaborate, mepronil, meptyldinocap, mercuric chloride, mercuric oxide, mercurous chloride, merphos, mesoprazine, mesosulfuron, mesosulfuron-methyl, mesotrione, mesulfen, mesulfenfos, metaflumizone, metalaxyl, metalaxyl-M, metaldehyde, metam, metam-ammonium, metamifop, metamitron, metam-potassium, metam-sodium, metazachlor, metazosulfuron, metazoxolon, metconazole, metepa, metflurazon, methabenzthiazuron, methacrifos, methalpropalin, methamidophos, methasulfocarb, methazole, methfuroxam, methidathion, methiobencarb, methiocarb, methiopyrisulfuron, methiotepa, methiozolin, methiuron, methocrotophos, methometon, methomyl, methoprene, methoprotryne, methoquin-butyl, methothrin, methoxychlor, methoxyfenozide, methoxyphenone, methyl apholate, methyl bromide, methyl eugenol, methyl iodide, methyl isothiocyanate, methylacetophos, methylchloroform, methyldymron, methylene chloride, methylmercury benzoate, methylmercury dicyandiamide, methylmercury pentachlorophenoxide, methylneodecanamide, metiram, metobenzuron, metobromuron, metofluthrin, metolachlor, metolcarb, metominostrobin, metosulam, metoxadiazone, metoxuron, metrafenone, metribuzin, metsulfovax, metsulfuron, metsulfuron-methyl, mevinphos, mexacarbate, mieshuan, milbemectin, milbemycin oxime, milneb, mipafox, mirex, MNAF, moguchun, molinate, molosultap, monalide, monisouron, monochloroacetic acid, monocrotophos, monolinuron, monosulfuron, monosulfuron-ester, monuron, monuron TCA, morfamquat, morfamquat dichloride, moroxydine, moroxydine hydrochloride, morphothion, morzid, moxidectin, MSMA, muscalure, myclobutanil, myclozolin, N-(ethylmercury)-p-toluenesulphonanilide, nabam, naftalofos, naled, naphthalene, naphthaleneacetamide, naphthalic anhydride, naphthoxyacetic acids, naproanilide, napropamide, naptalam, naptalam-sodium, natamycin, neburon, niclosamide, niclosamide-olamine, nicosulfuron, nicotine, nifluridide, nipyraclofen, nitenpyram, nithiazine, nitralin, nitrapyrin, nitrilacarb, nitrofen, nitrofluorfen, nitrostyrene, nitrothal-isopropyl, norbormide, norflurazon, nomicotine, noruron, novaluron, noviflumuron, nuarimol, OCH, octachlorodipropyl ether, octhilinone, ofurace, omethoate, orbencarb, orfralure, ortho-dichlorobenzene, orthosulfamuron, oryctalure, orysastrobin, oryzalin, osthol, ostramone, oxabetrinil, oxadiargyl, oxadiazon, oxadixyl, oxamate, oxamyl, oxapyrazon, oxapyrazon-dimolamine, oxapyrazon-sodium, oxasulfuron, oxaziclomefone, oxine-copper, oxolinic acid, oxpoconazole, oxpoconazole fumarate, oxycarboxin, oxydemeton-methyl, oxydeprofos, oxydisulfoton, oxyfluorfen, oxymatrine, oxytetracycline, oxytetracycline hydrochloride, paclobutrazol, paichongding, para-dichlorobenzene, parafluoron, paraquat, paraquat dichloride, paraquat dimetilsulfate, parathion, parathion-methyl, parinol, pebulate, pefurazoate, pelargonic acid, penconazole, pencycuron, pendimethalin, penflufen, penfluoron, penoxsulam, pentachlorophenol, pentanochlor, penthiopyrad, pentmethrin, pentoxazone, perfluidone, permethrin, pethoxamid, phenamacril, phenazine oxide, phenisopham, phenkapton, phenmedipham, phenmedipham-ethyl, phenobenzuron, phenothrin, phenproxide, phenthoate, phenylmercuriurea, phenylmercury acetate, phenylmercury chloride, phenylmercury derivative of pyrocatechol, phenylmercury nitrate, phenylmercury salicylate, phorate, phosacetim, phosalone, phosdiphen, phosfolan, phosfolan-methyl, phosglycin, phosmet, phosnichlor, phosphamidon, phosphine, phosphocarb, phosphorus, phostin, phoxim, phoxim-methyl, phthalide, picloram, picloram-2-ethylhexyl, picloram-isoctyl, picloram-methyl, picloram-olamine, picloram-potassium, picloram-triethylammonium, picloram-tris(2-hydroxypropyl)ammonium, picolinafen, picoxystrobin, pindone, pindone-sodium, pinoxaden, piperalin, piperonyl butoxide, piperonyl cyclonene, piperophos, piproctanyl, piproctanyl bromide, piprotal, pirimetaphos, pirimicarb, pirimioxyphos, pirimiphos-ethyl, pirimiphos-methyl, plifenate, polycarbamate, polyoxins, polyoxorim, polyoxorim-zinc, polythialan, potassium arsenite, potassium azide, potassium cyanate, potassium gibberellate, potassium naphthenate, potassium polysulfide, potassium thiocyanate, potassium α-naphthaleneacetate, pp′-DDT, prallethrin, precocene I, precocene II, precocene III, pretilachlor, primidophos, primisulfuron, primisulfuron-methyl, probenazole, prochloraz, prochloraz-manganese, proclonol, procyazine, procymidone, prodiamine, profenofos, profluazol, profluralin, profluthrin, profoxydim, proglinazine, proglinazine-ethyl, prohexadione, prohexadione-calcium, prohydrojasmon, promacyl, promecarb, prometon, prometryn, promurit, propachlor, propamidine, propamidine dihydrochloride, propamocarb, propamocarb hydrochloride, propanil, propaphos, propaquizafop, propargite, proparthrin, propazine, propetamphos, propham, propiconazole, propineb, propisochlor, propoxur, propoxycarbazone, propoxycarbazone-sodium, propyl isome, propyrisulfuron, propyzamide, proquinazid, prosuler, prosulfalin, prosulfocarb, prosulfuron, prothidathion, prothiocarb, prothiocarb hydrochloride, prothioconazole, prothiofos, prothoate, protrifenbute, proxan, proxan-sodium, prynachlor, pydanon, pymetrozine, pyracarbolid, pyraclofos, pyraclonil, pyraclostrobin, pyraflufen, pyraflufen-ethyl, pyrafluprole, pyramat, pyrametostrobin, pyraoxystrobin, pyrasulfotole, pyrazolynate, pyrazophos, pyrazosulfuron, pyrazosulfuron-ethyl, pyrazothion, pyrazoxyfen, pyresmethrin, pyrethrin I, pyrethrin II, pyrethrins, pyribambenz-isopropyl, pyribambenz-propyl, pyribencarb, pyribenzoxim, pyributicarb, pyriclor, pyridaben, pyridafol, pyridalyl, pyridaphenthion, pyridate, pyridinitril, pyrifenox, pyrifluquinazon, pyriftalid, pyrimethanil, pyrimidifen, pyriminobac, pyriminobac-methyl, pyrimisulfan, pyrimitate, pyrinuron, pyriofenone, pyriprole, pyripropanol, pyriproxyfen, pyrithiobac, pyrithiobac-sodium, pyrolan, pyroquilon, pyroxasulfone, pyroxsulam, pyroxychlor, pyroxyfur, quassia, quinacetol, quinacetol sulfate, quinalphos, quinalphos-methyl, quinazamid, quinclorac, quinconazole, quinmerac, quinoclamine, quinonamid, quinothion, quinoxyfen, quintiofos, quintozene, quizalofop, quizalofop-ethyl, quizalofop-P, quizalofop-P-ethyl, quizalofop-P-tefuryl, quwenzhi, quyingding, rabenzazole, rafoxanide, rebemide, resmethrin, rhodethanil, rhodojaponin-III, ribavirin, rimsulfuron, rotenone, ryania, saflufenacil, saijunmao, saisentong, salicylanilide, sanguinarine, santonin, schradan, scilliroside, sebuthylazine, secbumeton, sedaxane, selamectin, semiamitraz, semiamitraz chloride, sesamex, sesamolin, sethoxydim, shuangjiaancaolin, siduron, siglure, silafluofen, silatrane, silica gel, silthiofam, simazine, simeconazole, simeton, simetryn, sintofen, SMA, S-metolachlor, sodium arsenite, sodium azide, sodium chlorate, sodium fluoride, sodium fluoroacetate, sodium hexafluorosilicate, sodium naphthenate, sodium orthophenylphenoxide, sodium pentachlorophenoxide, sodium polysulfide, sodium thiocyanate, sodium α-naphthaleneacetate, sophamide, spinetoram, spinosad, spirodiclofen, spiromesifen, spirotetramat, spiroxamine, streptomycin, streptomycin sesquisulfate, strychnine, sulcatol, sulcofuron, sulcofuron-sodium, sulcotrione, sulfallate, sulfentrazone, sulfuram, sulfluramid, sulfometuron, sulfometuron-methyl, sulfosulfuron, sulfotep, sulfoxaflor, sulfoxide, sulfoxime, sulfur, sulfuric acid, sulfuryl fluoride, sulglycapin, sulprofos, sultropen, swep, tau-fluvalinate, tavron, tazimcarb, TCA, TCA-ammonium, TCA-calcium, TCA-ethadyl, TCA-magnesium, TCA-sodium, TDE, tebuconazole, tebufenozide, tebufenpyrad, tebufloquin, tebupirimfos, tebutam, tebuthiuron, tecloftalam, tecnazene, tecoram, teflubenzuron, tefluthrin, tefuryltrione, tembotrione, temephos, tepa, TEPP, tepraloxydim, terallethrin, terbacil, terbucarb, terbuchlor, terbufos, terbumeton, terbuthylazine, terbutryn, tetcyclacis, tetrachloroethane, tetrachlorvinphos, tetraconazole, tetradifon, tetrafluoron, tetramethrin, tetramethylfluthrin, tetramine, tetranactin, tetrasul, thallium sulfate, thenylchlor, theta-cypermethrin, thiabendazole, thiacloprid, thiadifluor, thiamethoxam, thiapronil, thiazafluoron, thiazopyr, thicrofos, thicyofen, thidiazimin, thidiazuron, thiencarbazone, thiencarbazone-methyl, thifensulfuron, thifensulfuron-methyl, thifluzamide, thiobencarb, thiocarboxime, thiochlorfenphim, thiocyclam, thiocyclam hydrochloride, thiocyclam oxalate, thiodiazole-copper, thiodicarb, thiofanox, thiofluoximate, thiohempa, thiomersal, thiometon, thionazin, thiophanate, thiophanate-methyl, thioquinox, thiosemicarbazide, thiosultap, thiosultap-diammonium, thiosultap-disodium, thiosultap-monosodium, thiotepa, thiram, thuringiensin, tiadinil, tiaojiean, tiocarbazil, tioclorim, tioxymid, tirpate, tolclofos-methyl, tolfenpyrad, tolylfluanid, tolylmercury acetate, topramezone, tralkoxydim, tralocythrin, tralomethrin, tralopyril, transfluthrin, transpermethrin, tretamine, triacontanol, triadimefon, triadimenol, triafamone, tri-allate, triamiphos, triapenthenol, triarathene, triarimol, triasulfuron, triazamate, triazbutil, triaziflam, triazophos, triazoxide, tribenuron, tribenuron-methyl, tribufos, tributyltin oxide, tricamba, trichlamide, trichlorfon, trichlormetaphos-3, trichloronat, triclopyr, triclopyr-butotyl, triclopyr-ethyl, triclopyr-triethylammonium, tricyclazole, tridemorph, tridiphane, trietazine, trifenmorph, trifenofos, trifloxystrobin, trifloxysulfuron, trifloxysulfuron-sodium, triflumizole, triflumuron, trifluralin, triflusulfuron, triflusulfuron-methyl, trifop, trifop-methyl, trifopsime, triforine, trihydroxytriazine, trimedlure, trimethacarb, trimeturon, trinexapac, trinexapac-ethyl, triprene, tripropindan, triptolide, tritac, triticonazole, tritosulfuron, trunc-call, uniconazole, uniconazole-P, urbacide, uredepa, valerate, validamycin, valifenalate, valone, vamidothion, vangard, vaniliprole, vernolate, vinclozolin, warfarin, warfarin-potassium, warfarin-sodium, xiaochongliulin, xinjunan, xiwojunan, XMC, xylachlor, xylenols, xylylcarb, yishijing, zarilamid, zeatin, zengxiaoan, zeta-cypermethrin, zinc naphthenate, zinc phosphide, zinc thiazole, zineb, ziram, zolaprofos, zoxamide, zuomihuanglong, α-chlorohydrin, α-ecdysone, α-multistriatin, and α-naphthaleneacetic acid. For more information consult the “COMPENDIUM OF PESTICIDE COMMON NAMES” located at http://www.alanwood.net/pesticides/index.html. Also consult “THE PESTICIDE MANUAL” 14th Edition, edited by C D S Tomlin, copyright 2006 by British Crop Production Council, or its prior or more recent editions.
Biopesticides
Molecules of Formula One may also be used in combination (such as in a compositional mixture, or a simultaneous or sequential application) with one or more biopesticides. The term “biopesticide” is used for microbial biological pest control agents that are applied in a similar manner to chemical pesticides. Commonly these are bacterial, but there are also examples of fungal control agents, including Trichoderma spp. and Ampelomyces quisqualis (a control agent for grape powdery mildew). Bacillus subtilis are used to control plant pathogens. Weeds and rodents have also been controlled with microbial agents. One well-known insecticide example is Bacillus thuringiensis, a bacterial disease of Lepidoptera, Coleoptera, and Diptera. Because it has little effect on other organisms, it is considered more environmentally friendly than synthetic pesticides. Biological insecticides include products based on:
1. entomopathogenic fungi (e.g. Metarhizium anisopliae);
2. entomopathogenic nematodes (e.g. Steinemema feltiae); and
3. entomopathogenic viruses (e.g. Cydia pomonella granulovirus).
Other examples of entomopathogenic organisms include, but are not limited to, baculoviruses, bacteria and other prokaryotic organisms, fungi, protozoa and Microsproridia. Biologically derived insecticides include, but not limited to, rotenone, veratridine, as well as microbial toxins; insect tolerant or resistant plant varieties; and organisms modified by recombinant DNA technology to either produce insecticides or to convey an insect resistant property to the genetically modified organism. In one embodiment, the molecules of Formula One may be used with one or more biopesticides in the area of seed treatments and soil amendments. The Manual of Biocontrol Agents gives a review of the available biological insecticide (and other biology-based control) products. Copping L. G. (ed.) (2004). The Manual of Biocontrol Agents (formerly the Biopesticide Manual) 3rd Edition. British Crop Production Council (BCPC), Farnham, Surrey UK.
Other Active Compounds
Molecules of Formula One may also be used in combination (such as in a compositional mixture, or a simultaneous or sequential application) with one or more of the following:

    1. 3-(4-chloro-2,6-dimethylphenyl)-4-hydroxy-8-oxa-1-azaspiro[4,5]dec-3-en-2-one;
    2. 3-(4′-chloro-2,4-dimethyl[1,1′-biphenyl]-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4,5]dec-3-en-2-one;
    3. 4-[[(6-chloro-3-pyridinyl)methyl]methylamino]-2(5H)-furanone;
    4. 4-[[(6-chloro-3-pyridinyl)methyl]cyclopropylamino]-2(5H)-furanone;
    5. 3-chloro-N2-[(1S)-1-methyl-2-(methylsulfonyl)ethyl]-N1-[2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]-1,2-benzenedicarboxamide;
    6. 2-cyano-N-ethyl-4-fluoro-3-methoxy-benenesulfonamide;
    7. 2-cyano-N-ethyl-3-methoxy-benzenesulfonamide;
    8. 2-cyano-3-difluoromethoxy-N-ethyl-4-fluoro-benzenesulfonamide;
    9. 2-cyano-3-fluoromethoxy-N-ethyl-benzenesulfonamide;
    10. 2-cyano-6-fluoro-3-methoxy-N,N-dimethyl-benzenesulfonamide;
    11. 2-cyano-N-ethyl-6-fluoro-3-methoxy-N-methyl-benzenesulfonamide;
    12. 2-cyano-3-difluoromethoxy-N,N-dimethylbenzenesulfon-amide;
    13. 3-(difluoromethyl)-N-[2-(3,3-dimethylbutyl)phenyl]-1-methyl-1H-pyrazole-4-carboxamide;
    14. N-ethyl-2,2-dimethylpropionamide-2-(2,6-dichloro-α,α,α-trifluoro-p-tolyl)hydrazone;
    15. N-ethyl-2,2-dichloro-1-methylcyclopropane-carboxamide-2-(2,6-dichloro-α,α,α-trifluoro-p-tolyl)hydrazone nicotine;
    16. 0-{(E-)-[2-(4-chloro-phenyl)-2-cyano-1-(2-trifluoromethylphenyl)-vinyl]}S-methyl thiocarbonate;
    17. (E)-N1-[(2-chloro-1,3-thiazol-5-ylmethyl)]-N2-cyano-N1-methylacetamidine;
    18. 1-(6-chloropyridin-3-ylmethyl)-7-methyl-8-nitro-1,2,3,5,6,7-hexahydro-imidazo[1,2-a]pyridin-5-ol;
    19. 4-[4-chlorophenyl-(2-butylidine-hydrazono)methyl)]phenyl mesylate; and
    20. N-Ethyl-2,2-dichloro-1-methylcyclopropanecarboxamide-2-(2,6-dichloro-alpha,alpha,alpha-trifluoro-p-tolyl)hydrazone.

Synergistic Mixtures



Molecules of Formula One may be used with certain active compounds to form synergistic mixtures where the mode of action of such compounds compared to the mode of action of the molecules of Formula One are the same, similar, or different. Examples of modes of action include, but are not limited to: acetylcholinesterase inhibitor; sodium channel modulator; chitin biosynthesis inhibitor; GABA and glutamate-gated chloride channel antagonist; GABA and glutamate-gated chloride channel agonist; acetylcholine receptor agonist; acetylcholine receptor antagonist; MET I inhibitor; Mg-stimulated ATPase inhibitor; nicotinic acetylcholine receptor; Midgut membrane disrupter; oxidative phosphorylation disrupter, and ryanodine receptor (RyRs). Generally, weight ratios of the molecules of Formula One in a synergistic mixture with another compound are from about 10:1 to about 1:10, in another embodiment from about 5:1 to about 1:5, and in another embodiment from about 3:1, and in another embodiment about 1:1.
Formulations
A pesticide is rarely suitable for application in its pure form. It is usually necessary to add other substances so that the pesticide can be used at the required concentration and in an appropriate form, permitting ease of application, handling, transportation, storage, and maximum pesticide activity. Thus, pesticides are formulated into, for example, baits, concentrated emulsions, dusts, emulsifiable concentrates, fumigants, gels, granules, microencapsulations, seed treatments, suspension concentrates, suspoemulsions, tablets, water soluble liquids, water dispersible granules or dry flowables, wettable powders, and ultra-low volume solutions. For further information on formulation types see “Catalogue of Pesticide Formulation Types and International Coding System” Technical Monograph n° 2, 5th Edition by CropLife International (2002).
Pesticides are applied most often as aqueous suspensions or emulsions prepared from concentrated formulations of such pesticides. Such water-soluble, water-suspendable, or emulsifiable formulations are either solids, usually known as wettable powders, or water dispersible granules, or liquids usually known as emulsifiable concentrates, or aqueous suspensions. Wettable powders, which may be compacted to form water dispersible granules, comprise an intimate mixture of the pesticide, a carrier, and surfactants. The concentration of the pesticide is usually from about 10% to about 90% by weight. The carrier is usually selected from among the attapulgite clays, the montmorillonite clays, the diatomaceous earths, or the purified silicates. Effective surfactants, comprising from about 0.5% to about 10% of the wettable powder, are found among sulfonated lignins, condensed naphthalenesulfonates, naphthalenesulfonates, alkylbenzenesulfonates, alkyl sulfates, and non-ionic surfactants such as ethylene oxide adducts of alkyl phenols.
Emulsifiable concentrates of pesticides comprise a convenient concentration of a pesticide, such as from about 50 to about 500 grams per liter of liquid dissolved in a carrier that is either a water miscible solvent or a mixture of water-immiscible organic solvent and emulsifiers. Useful organic solvents include aromatics, especially xylenes and petroleum fractions, especially the high-boiling naphthalenic and olefinic portions of petroleum such as heavy aromatic naphtha. Other organic solvents may also be used, such as the terpenic solvents including rosin derivatives, aliphatic ketones such as cyclohexanone, and complex alcohols such as 2-ethoxyethanol. Suitable emulsifiers for emulsifiable concentrates are selected from conventional anionic and non-ionic surfactants.
Aqueous suspensions comprise suspensions of water-insoluble pesticides dispersed in an aqueous carrier at a concentration in the range from about 5% to about 50% by weight. Suspensions are prepared by finely grinding the pesticide and vigorously mixing it into a carrier comprised of water and surfactants. Ingredients, such as inorganic salts and synthetic or natural gums may also be added, to increase the density and viscosity of the aqueous carrier. It is often most effective to grind and mix the pesticide at the same time by preparing the aqueous mixture and homogenizing it in an implement such as a sand mill, ball mill, or piston-type homogenizer.
Pesticides may also be applied as granular compositions that are particularly useful for applications to the soil. Granular compositions usually contain from about 0.5% to about 10% by weight of the pesticide, dispersed in a carrier that comprises clay or a similar substance. Such compositions are usually prepared by dissolving the pesticide in a suitable solvent and applying it to a granular carrier which has been pre-formed to the appropriate particle size, in the range of from about 0.5 to about 3 mm. Such compositions may also be formulated by making a dough or paste of the carrier and compound and crushing and drying to obtain the desired granular particle size.
Dusts containing a pesticide are prepared by intimately mixing the pesticide in powdered form with a suitable dusty agricultural carrier, such as kaolin clay, ground volcanic rock, and the like. Dusts can suitably contain from about 1% to about 10% of the pesticide. They can be applied as a seed dressing or as a foliage application with a dust blower machine.
It is equally practical to apply a pesticide in the form of a solution in an appropriate organic solvent, usually petroleum oil, such as the spray oils, which are widely used in agricultural chemistry.
Pesticides can also be applied in the form of an aerosol composition. In such compositions the pesticide is dissolved or dispersed in a carrier, which is a pressure-generating propellant mixture. The aerosol composition is packaged in a container from which the mixture is dispensed through an atomizing valve.
Pesticide baits are formed when the pesticide is mixed with food or an attractant or both. When the pests eat the bait they also consume the pesticide. Baits may take the form of granules, gels, flowable powders, liquids, or solids. They can be used in pest harborages.
Fumigants are pesticides that have a relatively high vapor pressure and hence can exist as a gas in sufficient concentrations to kill pests in soil or enclosed spaces. The toxicity of the fumigant is proportional to its concentration and the exposure time. They are characterized by a good capacity for diffusion and act by penetrating the pest's respiratory system or being absorbed through the pest's cuticle. Fumigants are applied to control stored product pests under gas proof sheets, in gas sealed rooms or buildings or in special chambers.
Pesticides can be microencapsulated by suspending the pesticide particles or droplets in plastic polymers of various types. By altering the chemistry of the polymer or by changing factors in the processing, microcapsules can be formed of various sizes, solubility, wall thicknesses, and degrees of penetrability. These factors govern the speed with which the active ingredient within is released, which in turn, affects the residual performance, speed of action, and odor of the product.
Oil solution concentrates are made by dissolving pesticide in a solvent that will hold the pesticide in solution. Oil solutions of a pesticide usually provide faster knockdown and kill of pests than other formulations due to the solvents themselves having pesticidal action and the dissolution of the waxy covering of the integument increasing the speed of uptake of the pesticide. Other advantages of oil solutions include better storage stability, better penetration of crevices, and better adhesion to greasy surfaces.
Another embodiment is an oil-in-water emulsion, wherein the emulsion comprises oily globules which are each provided with a lamellar liquid crystal coating and are dispersed in an aqueous phase, wherein each oily globule comprises at least one compound which is agriculturally active, and is individually coated with a monolamellar or oligolamellar layer comprising: (1) at least one non-ionic lipophilic surface-active agent, (2) at least one non-ionic hydrophilic surface-active agent and (3) at least one ionic surface-active agent, wherein the globules having a mean particle diameter of less than 800 nanometers. Further information on the embodiment is disclosed in U.S. patent publication 20070027034 published Feb. 1, 2007, having patent application Ser. No. 11/495,228. For ease of use, this embodiment will be referred to as “OIWE”.
For further information consult “Insect Pest Management” 2nd Edition by D. Dent, copyright CAB International (2000). Additionally, for more detailed information consult “Handbook of Pest Control—The Behavior, Life History, and Control of Household Pests” by Arnold Mallis, 9th Edition, copyright 2004 by GIE Media Inc.
Other Formulation Components
Generally, when the molecules disclosed in Formula One are used in a formulation, such formulation can also contain other components. These components include, but are not limited to, (this is a non-exhaustive and non-mutually exclusive list) wetters, spreaders, stickers, penetrants, buffers, sequestering agents, drift reduction agents, compatibility agents, anti-foam agents, cleaning agents, and emulsifiers. A few components are described forthwith.
A wetting agent is a substance that when added to a liquid increases the spreading or penetration power of the liquid by reducing the interfacial tension between the liquid and the surface on which it is spreading. Wetting agents are used for two main functions in agrochemical formulations: during processing and manufacture to increase the rate of wetting of powders in water to make concentrates for soluble liquids or suspension concentrates; and during mixing of a product with water in a spray tank to reduce the wetting time of wettable powders and to improve the penetration of water into water-dispersible granules. Examples of wetting agents used in wettable powder, suspension concentrate, and water-dispersible granule formulations are: sodium lauryl sulfate; sodium dioctyl sulfosuccinate; alkyl phenol ethoxylates; and aliphatic alcohol ethoxylates.
A dispersing agent is a substance which adsorbs onto the surface of particles and helps to preserve the state of dispersion of the particles and prevents them from reaggregating. Dispersing agents are added to agrochemical formulations to facilitate dispersion and suspension during manufacture, and to ensure the particles redisperse into water in a spray tank. They are widely used in wettable powders, suspension concentrates and water-dispersible granules. Surfactants that are used as dispersing agents have the ability to adsorb strongly onto a particle surface and provide a charged or steric barrier to reaggregation of particles. The most commonly used surfactants are anionic, non-ionic, or mixtures of the two types. For wettable powder formulations, the most common dispersing agents are sodium lignosulfonates. For suspension concentrates, very good adsorption and stabilization are obtained using polyelectrolytes, such as sodium naphthalene sulfonate formaldehyde condensates. Tristyrylphenol ethoxylate phosphate esters are also used. Non-ionics such as alkylarylethylene oxide condensates and EO-PO block copolymers are sometimes combined with anionics as dispersing agents for suspension concentrates. In recent years, new types of very high molecular weight polymeric surfactants have been developed as dispersing agents. These have very long hydrophobic ‘backbones’ and a large number of ethylene oxide chains forming the ‘teeth’ of a ‘comb’ surfactant. These high molecular weight polymers can give very good long-term stability to suspension concentrates because the hydrophobic backbones have many anchoring points onto the particle surfaces. Examples of dispersing agents used in agrochemical formulations are: sodium lignosulfonates; sodium naphthalene sulfonate formaldehyde condensates; tristyrylphenol ethoxylate phosphate esters; aliphatic alcohol ethoxylates; alkyl ethoxylates; EO-PO block copolymers; and graft copolymers.
An emulsifying agent is a substance which stabilizes a suspension of droplets of one liquid phase in another liquid phase. Without the emulsifying agent the two liquids would separate into two immiscible liquid phases. The most commonly used emulsifier blends contain alkylphenol or aliphatic alcohol with twelve or more ethylene oxide units and the oil-soluble calcium salt of dodecylbenzenesulfonic acid. A range of hydrophile-lipophile balance (“HLB”) values from 8 to 18 will normally provide good stable emulsions. Emulsion stability can sometimes be improved by the addition of a small amount of an EO-PO block copolymer surfactant.
A solubilizing agent is a surfactant which will form micelles in water at concentrations above the critical micelle concentration. The micelles are then able to dissolve or solubilize water-insoluble materials inside the hydrophobic part of the micelle. The types of surfactants usually used for solubilization are non-ionics, sorbitan monooleates, sorbitan monooleate ethoxylates, and methyl oleate esters.
Surfactants are sometimes used, either alone or with other additives such as mineral or vegetable oils as adjuvants to spray-tank mixes to improve the biological performance of the pesticide on the target. The types of surfactants used for bioenhancement depend generally on the nature and mode of action of the pesticide. However, they are often non-ionics such as: alkyl ethoxylates; linear aliphatic alcohol ethoxylates; aliphatic amine ethoxylates.
A carrier or diluent in an agricultural formulation is a material added to the pesticide to give a product of the required strength. Carriers are usually materials with high absorptive capacities, while diluents are usually materials with low absorptive capacities. Carriers and diluents are used in the formulation of dusts, wettable powders, granules and water-dispersible granules.
Organic solvents are used mainly in the formulation of emulsifiable concentrates, oil-in-water emulsions, suspoemulsions, and ultra-low volume formulations, and to a lesser extent, granular formulations. Sometimes mixtures of solvents are used. The first main groups of solvents are aliphatic paraffinic oils such as kerosene or refined paraffins. The second main group (and the most common) comprises the aromatic solvents such as xylene and higher molecular weight fractions of C9 and C10 aromatic solvents. Chlorinated hydrocarbons are useful as cosolvents to prevent crystallization of pesticides when the formulation is emulsified into water. Alcohols are sometimes used as cosolvents to increase solvent power. Other solvents may include vegetable oils, seed oils, and esters of vegetable and seed oils.
Thickeners or gelling agents are used mainly in the formulation of suspension concentrates, emulsions and suspoemulsions to modify the rheology or flow properties of the liquid and to prevent separation and settling of the dispersed particles or droplets. Thickening, gelling, and anti-settling agents generally fall into two categories, namely water-insoluble particulates and water-soluble polymers. It is possible to produce suspension concentrate formulations using clays and silicas. Examples of these types of materials, include, but are not limited to, montmorillonite, bentonite, magnesium aluminum silicate, and attapulgite. Water-soluble polysaccharides have been used as thickening-gelling agents for many years. The types of polysaccharides most commonly used are natural extracts of seeds and seaweeds or are synthetic derivatives of cellulose. Examples of these types of materials include, but are not limited to, guar gum; locust bean gum; carrageenam; alginates; methyl cellulose; sodium carboxymethyl cellulose (SCMC); hydroxyethyl cellulose (HEC). Other types of anti-settling agents are based on modified starches, polyacrylates, polyvinyl alcohol and polyethylene oxide. Another good anti-settling agent is xanthan gum.
Microorganisms can cause spoilage of formulated products. Therefore preservation agents are used to eliminate or reduce their effect. Examples of such agents include, but are not limited to: propionic acid and its sodium salt; sorbic acid and its sodium or potassium salts; benzoic acid and its sodium salt; p-hydroxybenzoic acid sodium salt; methyl p-hydroxybenzoate; and 1,2-benzisothiazolin-3-one (BIT).
The presence of surfactants often causes water-based formulations to foam during mixing operations in production and in application through a spray tank. In order to reduce the tendency to foam, anti-foam agents are often added either during the production stage or before filling into bottles. Generally, there are two types of anti-foam agents, namely silicones and non-silicones. Silicones are usually aqueous emulsions of dimethyl polysiloxane, while the non-silicone anti-foam agents are water-insoluble oils, such as octanol and nonanol, or silica. In both cases, the function of the anti-foam agent is to displace the surfactant from the air-water interface.
“Green” agents (e.g., adjuvants, surfactants, solvents) can reduce the overall environmental footprint of crop protection formulations. Green agents are biodegradable and generally derived from natural and/or sustainable sources, e.g. plant and animal sources. Specific examples are: vegetable oils, seed oils, and esters thereof, also alkoxylated alkyl polyglucosides.
For further information, see “Chemistry and Technology of Agrochemical Formulations” edited by D. A. Knowles, copyright 1998 by Kluwer Academic Publishers. Also see “Insecticides in Agriculture and Environment—Retrospects and Prospects” by A. S. Perry, I. Yamamoto, I. Ishaaya, and R. Perry, copyright 1998 by Springer-Verlag.
Pests
In general, the molecules of Formula One may be used to control pests e.g. beetles, earwigs, cockroaches, flies. aphids, scales, whiteflies, leafhoppers, ants, wasps, termites, moths, butterflies, lice, grasshoppers, locusts, crickets, fleas, thrips, bristletails, mites, ticks, nematodes, and symphylans.
In another embodiment, the molecules of Formula One may be used to control pests in the Phyla Nematoda and/or Arthropoda.
In another embodiment, the molecules of Formula One may be used to control pests in the Subphyla Chelicerata, Myriapoda, and/or Hexapoda.
In another embodiment, the molecules of Formula One may be used to control pests in the Classes of Arachnida, Symphyla, and/or Insecta.
In another embodiment, the molecules of Formula One may be used to control pests of the Order Anoplura. A non-exhaustive list of particular genera includes, but is not limited to, Haematopinus spp., Hoplopleura spp., Linognathus spp., Pediculus spp., and Polyplax spp. A non-exhaustive list of particular species includes, but is not limited to, Haematopinus asini, Haematopinus suis, Linognathus setosus, Linognathus ovillus, Pediculus humanus capitis, Pediculus humanus humanus, and Pthirus pubis. 
In another embodiment, the molecules of Formula One may be used to control pests in the Order Coleoptera. A non-exhaustive list of particular genera includes, but is not limited to, Acanthoscelides spp., Agriotes spp., Anthonomus spp., Apion spp., Apogonia spp., Aulacophora spp., Bruchus spp., Cerosterna spp., Cerotoma spp., Ceutorhynchus spp., Chaetocnema spp., Colaspis spp., Ctenicera spp., Curculio spp., Cyclocephala spp., Diabrotica spp., Hypera spp., Ips spp., Lyctus spp., Megascelis spp., Meligethes spp., Otiorhynchus spp., Pantomorus spp., Phyllophaga spp., Phyllotreta spp., Rhizotrogus spp., Rhynchites spp., Rhynchophorus spp., Scolytus spp., Sphenophorus spp., Sitophilus spp., and Tribolium spp. A non-exhaustive list of particular species includes, but is not limited to, Acanthoscelides obtectus, Agrilus planipennis, Anoplophora glabripennis, Anthonomus grandis, Ataenius spretulus, Atomaria linearis, Bothynoderes punctiventris, Bruchus pisorum, Callosobruchus maculatus, Carpophilus hemipterus, Cassida vittata, Cerotoma trifurcata, Ceutorhynchus assimilis, Ceutorhynchus napi, Conoderus scalaris, Conoderus stigmosus, Conotrachelus nenuphar, Cotinis nitida, Crioceris asparagi, Cryptolestes ferrugineus, Cryptolestes pusillus, Cryptolestes turcicus, Cylindrocopturus adspersus, Deporaus marginatus, Dermestes lardarius, Dermestes maculatus, Epilachna varivestis, Faustinus cubae, Hylobius pales, Hypera postica, Hypothenemus hampei, Lasioderma serricorne, Leptinotarsa decemlineata, Liogenys fiiscus, Liogenys suturalis, Lissorhoptrus oryzophilus, Maecolaspis joliveti, Melanotus communis, Meligethes aeneus, Melolontha melolontha, Oberea brevis, Oberea linearis, Oryctes rhinoceros, Oryzaephilus mercator, Oryzaephilus surinamensis, Oulema melanopus, Oulema oryzae, Phyllophaga cuyabana, Popillia japonica, Prostephanus truncatus, Rhyzopertha dominica, Sitona lineatus, Sitophilus granarius, Sitophilus oryzae, Sitophilus zeamais, Stegobium paniceum, Tribolium castaneum, Tribolium confusum, Trogoderma variabile, and Zabrus tenebrioides. 
In another embodiment, the molecules of Formula One may be used to control pests of the Order Dermaptera.
In another embodiment, the molecules of Formula One may be used to control pests of the Order Blattaria. A non-exhaustive list of particular species includes, but is not limited to, Blattella germanica, Blatta orientalis, Parcoblatta pennsylvanica, Periplaneta americana, Periplaneta australasiae, Periplaneta brunnea, Periplaneta fuliginosa, Pycnoscelus surinamensis, and Supella longipalpa. 
In another embodiment, the molecules of Formula One may be used to control pests of the Order Diptera. A non-exhaustive list of particular genera includes, but is not limited to, Aedes spp., Agromyza spp., Anastrepha spp., Anopheles spp., Bactrocera spp., Ceratitis spp., Chrysops spp., Cochliomyia spp., Contarinia spp., Culex spp., Dasineura spp., Delia spp., Drosophila spp., Fannia spp., Hylemyia spp., Liriomyza spp., Musca spp., Phorbia spp., Tabanus spp., and Tipula spp. A non-exhaustive list of particular species includes, but is not limited to, Agromyza frontella, Anastrepha suspensa, Anastrepha ludens, Anastrepha obliqa, Bactrocera cucurbitae, Bactrocera dorsalis, Bactrocera invadens, Bactrocera zonata, Ceratitis capitata, Dasineura brassicae, Delia platura, Fannia canicularis, Fannia scalaris, Gasterophilus intestinalis, Gracillia perseae, Haematobia irritans, Hypoderma lineatum, Liriomyza brassicae, Melophagus ovinus, Musca autumnalis, Musca domestica, Oestrus ovis, Oscinella frit, Pegomya betae, Psila rosae, Rhagoletis cerasi, Rhagoletis pomonella, Rhagoletis mendax, Sitodiplosis mosellana, and Stomoxys calcitrans. 
In another embodiment, the molecules of Formula One may be used to control pests of the Order Hemiptera. A non-exhaustive list of particular genera includes, but is not limited to, Adelges spp., Aulacaspis spp., Aphrophora spp., Aphis spp., Bemisia spp., Ceroplastes spp., Chionaspis spp., Chrysomphalus spp., Coccus spp., Empoasca spp., Lepidosaphes spp., Lagynotomus spp., Lygus spp., Macrosiphum spp., Nephotettix spp., Nezara spp., Philaenus spp., Phytocoris spp., Piezodorus spp., Planococcus spp., Pseudococcus spp., Rhopalosiphum spp., Saissetia spp., Therioaphis spp., Toumeyella spp., Toxoptera spp., Trialeurodes spp., Triatoma spp. and Unaspis spp. A non-exhaustive list of particular species includes, but is not limited to, Acrosternum hilare, Acyrthosiphon pisum, Aleyrodes proletella, Aleurodicus dispersus, Aleurothrixus floccosus, Amrasca biguttula biguttula, Aonidiella aurantii, Aphis gossypii, Aphis glycines, Aphis pomi, Aulacorthum solani, Bemisia argentifolii, Bemisia tabaci, Blissus leucopterus, Brachycorynella asparagi, Brevennia rehi, Brevicoryne brassicae, Calocoris norvegicus, Ceroplastes rubens, Cimex hemipterus, Cimex lectularius, Dagbertus fasciatus, Dichelops furcatus, Diuraphis noxia, Diaphorina citri, Dysaphis plantaginea, Dysdercus suturellus, Edessa meditabunda, Eriosoma lanigerum, Eurygaster maura, Euschistus heros, Euschistus servus, Helopeltis antonii, Helopeltis theivora, Icerya purchasi, Idioscopus nitidulus, Laodelphax striatellus, Leptocorisa oratorius, Leptocorisa varicornis, Lygus hesperus, Maconellicoccus hirsutus, Macrosiphum euphorbiae, Macrosiphum granarium, Macrosiphum rosae, Macrosteles quadrilineatus, Mahanarva frimbiolata, Metopolophium dirhodum, Mictis longicornis, Myzus persicae, Nephotettix cinctipes, Neurocolpus longirostris, Nezara viridula, Nilaparvata lugens, Parlatoria pergandii, Parlatoria ziziphi, Peregrinus maidis, Phylloxera vitifoliae, Physokermes piceae, Phytocoris californicus, Phytocoris relativus, Piezodorus guildinii, Poecilocapsus lineatus, Psallus vaccinicola, Pseudacysta perseae, Pseudococcus brevipes, Quadraspidiotus perniciosus, Rhopalosiphum maidis, Rhopalosiphum padi, Saissetia oleae, Scaptocoris castanea, Schizaphis graminum, Sitobion avenae, Sogatella furcifera, Trialeurodes vaporariorum, Trialeurodes abutiloneus, Unaspis yanonensis, and Zulia entrerriana. 
In another embodiment, the molecules of Formula One may be used to control pests of the Order Hymenoptera. A non-exhaustive list of particular genera includes, but is not limited to, Acromyrmex spp., Atta spp., Camponotus spp., Diprion spp., Formica spp., Monomorium spp., Neodiprion spp., Pogonomyrmex spp., Polistes spp., Solenopsis spp., Vespula spp., and Xylocopa spp. A non-exhaustive list of particular species includes, but is not limited to, Athalia rosae, Atta texana, Iridomyrmex humilis, Monomorium minimum, Monomorium pharaonis, Solenopsis invicta, Solenopsis geminata, Solenopsis molesta, Solenopsis richtery, Solenopsis xyloni, and Tapinoma sessile. 
In another embodiment, the molecules of Formula One may be used to control pests of the Order Isoptera. A non-exhaustive list of particular genera includes, but is not limited to, Coptotermes spp., Cornitermes spp., Cryptotermes spp., Heterotermes spp., Kalotermes spp., Incisitermes spp., Macrotermes spp., Marginitermes spp., Microcerotermes spp., Procornitermes spp., Reticulitermes spp., Schedorhinotermes spp., and Zootermopsis spp. A non-exhaustive list of particular species includes, but is not limited to, Coptotermes curvignathus, Coptotermes frenchi, Coptotermes formosanus, Heterotermes aureus, Microtermes obesi, Reticulitermes banyulensis, Reticulitermes grassei, Reticulitermes flavipes, Reticulitermes hageni, Reticulitermes hesperus, Reticulitermes santonensis, Reticulitermes speratus, Reticulitermes tibialis, and Reticulitermes virginicus. 
In another embodiment, the molecules of Formula One may be used to control pests of the Order Lepidoptera. A non-exhaustive list of particular genera includes, but is not limited to, Adoxophyes spp., Agrotis spp., Argyrotaenia spp., Cacoecia spp., Caloptilia spp., Chilo spp., Chrysodeixis spp., Colias spp., Crambus spp., Diaphania spp., Diatraea spp., Earias spp., Ephestia spp., Epimecis spp., Feltia spp., Gortyna spp., Helicoverpa spp., Heliothis spp., Indarbela spp., Lithocolletis spp., Loxagrotis spp., Malacosoma spp., Peridroma spp., Phyllonorycter spp., Pseudaletia spp., Sesamia spp., Spodoptera spp., Synanthedon spp., and Yponomeuta spp. A non-exhaustive list of particular species includes, but is not limited to, Achaea janata, Adoxophyes orana, Agrotis ipsilon, Alabama argillacea, Amorbia cuneana, Amyelois transitella, Anacamptodes defectaria, Anarsia lineatella, Anomis sabulifera, Anticarsia gemmatalis, Archips argyrospila, Archips rosana, Argyrotaenia citrana, Autographa gamma, Bonagota cranaodes, Borbo cinnara, Bucculatrix thurberiella, Capua reticulana, Carposina niponensis, Chlumetia transversa, Choristoneura rosaceana, Cnaphalocrocis medinalis, Conopomorpha cramerella, Cossus cossus, Cydia caryana, Cydia funebrana, Cydia molesta, Cydia nigricana, Cydia pomonella, Darna diducta, Diatraea saccharalis, Diatraea grandiosella, Earias insulana, Earias vittella, Ecdytolopha aurantianum, Elasmopalpus lignosellus, Ephestia cautella, Ephestia elutella, Ephestia kuehniella, Epinotia aporema, Epiphyas postvittana, Erionota thrax, Eupoecilia ambiguella, Euxoa auxiliaris, Grapholita molesta, Hedylepta indicata, Helicoverpa armigera, Helicoverpa zea, Heliothis virescens, Hellula undalis, Keiferia lycopersicella, Leucinodes orbonalis, Leucoptera coffeella, Leucoptera malifoliella, Lobesia botrana, Loxagrotis albicosta, Lymantria dispar, Lyonetia clerkella, Mahasena corbetti, Mamestra brassicae, Maruca testulalis, Metisa plana, Mythimna unipuncta, Neoleucinodes elegantalis, Nymphula depunctalis, Operophtera brumata, Ostrinia nubilalis, Oxydia vesulia, Pandemis cerasana, Pandemis heparana, Papilio demodocus, Pectinophora gossypiella, Peridroma saucia, Perileucoptera coffeella, Phthorimaea operculella, Phyllocnistis citrella, Pieris rapae, Plathypena scabra, Plodia interpunctella, Plutella xylostella, Polychrosis viteana, Prays endocarpa, Prays oleae, Pseudaletia unipuncta, Pseudoplusia includens, Rachiplusia nu, Scirpophaga incertulas, Sesamia inferens, Sesamia nonagrioides, Setora nitens, Sitotroga cerealella, Sparganothis pilleriana, Spodoptera exigua, Spodoptera frugiperda, Spodoptera eridania, Thecla basilides, Tineola bisselliella, Trichoplusia ni, Tuta absoluta, Zeuzera coffeae, and Zeuzera pyrina. 
In another embodiment, the molecules of Formula One may be used to control pests of the Order Mallophaga. A non-exhaustive list of particular genera includes, but is not limited to, Anaticola spp., Bovicola spp., Chelopistes spp., Goniodes spp., Menacanthus spp., and Trichodectes spp. A non-exhaustive list of particular species includes, but is not limited to, Bovicola bovis, Bovicola caprae, Bovicola ovis, Chelopistes meleagridis, Goniodes dissimilis, Goniodes gigas, Menacanthus stramineus, Menopon gallinae, and Trichodectes canis. 
In another embodiment, the molecules of Formula One may be used to control pests of the Order Orthoptera. A non-exhaustive list of particular genera includes, but is not limited to, Melanoplus spp., and Pterophylla spp. A non-exhaustive list of particular species includes, but is not limited to, Anabrus simplex, Gryllotalpa africana, Gryllotalpa australis, Gryllotalpa brachyptera, Gryllotalpa hexadactyla, Locusta migratoria, Microcentrum retinerve, Schistocerca gregaria, and Scudderia furcata. 
In another embodiment, the molecules of Formula One may be used to control pests of the Order Siphonaptera. A non-exhaustive list of particular species includes, but is not limited to, Ceratophyllus gallinae, Ceratophyllus niger, Ctenocephalides canis, Ctenocephalides felis, and Pulex irritans. 
In another embodiment, the molecules of Formula One may be used to control pests of the Order Thysanoptera. A non-exhaustive list of particular genera includes, but is not limited to, Caliothrips spp., Frankliniella spp., Scirtothrips spp., and Thrips spp. A non-exhaustive list of particular sp. includes, but is not limited to, Frankliniella fiisca, Frankliniella occidentalis, Frankliniella schultzei, Frankliniella williamsi, Heliothrips haemorrhoidalis, Rhipiphorothrips cruentatus, Scirtothrips citri, Scirtothrips dorsalis, and Taeniothrips rhopalantennalis, Thrips hawaiiensis, Thrips nigropilosus, Thrips orientalis, Thrips tabaci. 
In another embodiment, the molecules of Formula One may be used to control pests of the Order Thysanura. A non-exhaustive list of particular genera includes, but is not limited to, Lepisma spp. and Thermobia spp.
In another embodiment, the molecules of Formula One may be used to control pests of the Order Acarina. A non-exhaustive list of particular genera includes, but is not limited to, Acarus spp., Aculops spp., Boophilus spp., Demodex spp., Dermacentor spp., Epitrimerus spp., Eriophyes spp., Ixodes spp., Oligonychus spp., Panonychus spp., Rhizoglyphus spp., and Tetranychus spp. A non-exhaustive list of particular species includes, but is not limited to, Acarapis woodi, Acarus siro, Aceria mangiferae, Aculops lycopersici, Aculus pelekassi, Aculus schlechtendali, Amblyomma americanum, Brevipalpus obovatus, Brevipalpus phoenicis, Dermacentor variabilis, Dermatophagoides pteronyssinus, Eotetranychus carpini, Notoedres cati, Oligonychus coffeae, Oligonychus ilicis, Panonychus citri, Panonychus ulmi, Phyllocoptruta oleivora, Polyphagotarsonemus latus, Rhipicephalus sanguineus, Sarcoptes scabiei, Tegolophus perseaflorae, Tetranychus urticae, and Varroa destructor. 
In another embodiment, the molecules of Formula One may be used to control pest of the Order Symphyla. A non-exhaustive list of particular sp. includes, but is not limited to, Scutigerella immaculata. 
In another embodiment, the molecules of Formula One may be used to control pests of the Phylum Nematoda. A non-exhaustive list of particular genera includes, but is not limited to, Aphelenchoides spp., Belonolaimus spp., Criconemella spp., Ditylenchus spp., Heterodera spp., Hirschmanniella spp., Hoplolaimus spp., Meloidogyne spp., Pratylenchus spp., and Radopholus spp. A non-exhaustive list of particular sp. includes, but is not limited to, Dirofilaria immitis, Heterodera zeae, Meloidogyne incognita, Meloidogyne javanica, Onchocerca volvulus, Radopholus similis, and Rotylenchulus reniformis. 
For additional information consult “HANDBOOK OF PEST CONTROL—THE BEHAVIOR, LIFE HISTORY, AND CONTROL OF HOUSEHOLD PESTS” by Arnold Mallis, 9th Edition, copyright 2004 by GIE Media Inc.
Applications
Molecules of Formula One are generally used in amounts from about 0.01 grams per hectare to about 5000 grams per hectare to provide control. Amounts from about 0.1 grams per hectare to about 500 grams per hectare are generally preferred, and amounts from about 1 gram per hectare to about 50 grams per hectare are generally more preferred.
The area to which a molecule of Formula One is applied can be any area inhabited (or maybe inhabited, or traversed by) a pest, for example: where crops, trees, fruits, cereals, fodder species, vines, turf and ornamental plants, are growing; where domesticated animals are residing; the interior or exterior surfaces of buildings (such as places where grains are stored), the materials of construction used in building (such as impregnated wood), and the soil around buildings. Particular crop areas to use a molecule of Formula One include areas where apples, corn, sunflowers, cotton, soybeans, canola, wheat, rice, sorghum, barley, oats, potatoes, oranges, alfalfa, lettuce, strawberries, tomatoes, peppers, crucifers, pears, tobacco, almonds, sugar beets, beans and other valuable crops are growing or the seeds thereof are going to be planted. It is also advantageous to use ammonium sulfate with a molecule of Formula One when growing various plants.
Controlling pests generally means that pest populations, pest activity, or both, are reduced in an area. This can come about when: pest populations are repulsed from an area; when pests are incapacitated in or around an area; or pests are exterminated, in whole, or in part, in or around an area. Of course, a combination of these results can occur. Generally, pest populations, activity, or both are desirably reduced more than fifty percent, preferably more than 90 percent. Generally, the area is not in or on a human; consequently, the locus is generally a non-human area.
The molecules of Formula One may be used in mixtures, applied simultaneously or sequentially, alone or with other compounds to enhance plant vigor (e.g. to grow a better root system, to better withstand stressful growing conditions). Such other compounds are, for example, compounds that modulate plant ethylene receptors, most notably 1-methylcyclopropene (also known as 1-MCP). Furthermore, such molecules may be used during times when pest activity is low, such as before the plants that are growing begin to produce valuable agricultural commodities. Such times include the early planting season when pest pressure is usually low.
The molecules of Formula One can be applied to the foliar and fruiting portions of plants to control pests. The molecules will either come in direct contact with the pest, or the pest will consume the pesticide when eating leaf, fruit mass, or extracting sap, that contains the pesticide. The molecules of Formula One can also be applied to the soil, and when applied in this manner, root and stem feeding pests can be controlled. The roots can absorb a molecule taking it up into the foliar portions of the plant to control above ground chewing and sap feeding pests.
Generally, with baits, the baits are placed in the ground where, for example, termites can come into contact with, and/or be attracted to, the bait. Baits can also be applied to a surface of a building, (horizontal, vertical, or slant surface) where, for example, ants, termites, cockroaches, and flies, can come into contact with, and/or be attracted to, the bait. Baits can comprise a molecule of Formula One.
The molecules of Formula One can be encapsulated inside, or placed on the surface of a capsule. The size of the capsules can range from nanometer size (about 100-900 nanometers in diameter) to micrometer size (about 10-900 microns in diameter).
Because of the unique ability of the eggs of some pests to resist certain pesticides, repeated applications of the molecules of Formula One may be desirable to control newly emerged larvae.
Systemic movement of pesticides in plants may be utilized to control pests on one portion of the plant by applying (for example by spraying an area) the molecules of Formula One to a different portion of the plant. For example, control of foliar-feeding insects can be achieved by drip irrigation or furrow application, by treating the soil with for example pre- or post-planting soil drench, or by treating the seeds of a plant before planting.
Seed treatment can be applied to all types of seeds, including those from which plants genetically modified to express specialized traits will germinate. Representative examples include those expressing proteins toxic to invertebrate pests, such as Bacillus thuringiensis or other insecticidal toxins, those expressing herbicide resistance, such as “Roundup Ready” seed, or those with “stacked” foreign genes expressing insecticidal toxins, herbicide resistance, nutrition-enhancement, drought resistance, or any other beneficial traits. Furthermore, such seed treatments with the molecules of Formula One may further enhance the ability of a plant to better withstand stressful growing conditions. This results in a healthier, more vigorous plant, which can lead to higher yields at harvest time. Generally, about 1 gram of the molecules of Formula One to about 500 grams per 100,000 seeds is expected to provide good benefits, amounts from about 10 grams to about 100 grams per 100,000 seeds is expected to provide better benefits, and amounts from about 25 grams to about 75 grams per 100,000 seeds is expected to provide even better benefits.
It should be readily apparent that the molecules of Formula One may be used on, in, or around plants genetically modified to express specialized traits, such as Bacillus thuringiensis or other insecticidal toxins, or those expressing herbicide resistance, or those with “stacked” foreign genes expressing insecticidal toxins, herbicide resistance, nutrition-enhancement, or any other beneficial traits.
The molecules of Formula One may be used for controlling endoparasites and ectoparasites in the veterinary medicine sector or in the field of non-human animal keeping. The molecules of Formula One are applied, such as by oral administration in the form of, for example, tablets, capsules, drinks, granules, by dermal application in the form of, for example, dipping, spraying, pouring on, spotting on, and dusting, and by parenteral administration in the form of, for example, an injection.
The molecules of Formula One may also be employed advantageously in livestock keeping, for example, cattle, sheep, pigs, chickens, and geese. They may also be employed advantageously in pets such as, horses, dogs, and cats. Particular pests to control would be fleas and ticks that are bothersome to such animals. Suitable formulations are administered orally to the animals with the drinking water or feed. The dosages and formulations that are suitable depend on the species.
The molecules of Formula One may also be used for controlling parasitic worms, especially of the intestine, in the animals listed above.
The molecules of Formula One may also be employed in therapeutic methods for human health care. Such methods include, but are limited to, oral administration in the form of, for example, tablets, capsules, drinks, granules, and by dermal application.
Pests around the world have been migrating to new environments (for such pest) and thereafter becoming a new invasive species in such new environment. The molecules of Formula One may also be used on such new invasive species to control them in such new environment.
The molecules of Formula One may also be used in an area where plants, such as crops, are growing (e.g. pre-planting, planting, pre-harvesting) and where there are low levels (even no actual presence) of pests that can commercially damage such plants. The use of such molecules in such area is to benefit the plants being grown in the area. Such benefits, may include, but are not limited to, improving the health of a plant, improving the yield of a plant (e.g. increased biomass and/or increased content of valuable ingredients), improving the vigor of a plant (e.g. improved plant growth and/or greener leaves), improving the quality of a plant (e.g. improved content or composition of certain ingredients), and improving the tolerance to abiotic and/or biotic stress of the plant.
Before a pesticide can be used or sold commercially, such pesticide undergoes lengthy evaluation processes by various governmental authorities (local, regional, state, national, and international). Voluminous data requirements are specified by regulatory authorities and must be addressed through data generation and submission by the product registrant or by a third party on the product registrant's behalf, often using a computer with a connection to the World Wide Web. These governmental authorities then review such data and if a determination of safety is concluded, provide the potential user or seller with product registration approval. Thereafter, in that locality where the product registration is granted and supported, such user or seller may use or sell such pesticide.
A molecule according to Formula One can be tested to determine its efficacy against pests. Furthermore, mode of action studies can be conducted to determine if said molecule has a different mode of action than other pesticides. Thereafter, such acquired data can be disseminated, such as by the internet, to third parties.
The headings in this document are for convenience only and must not be used to interpret any portion hereof.
Table Section













% Control (or Mortality)
Rating















BAW, CEW & CL Rating Table










50-100
A



More than 0-Less than 50
B



Not Tested
C



No activity noticed in this bioassay
D







GPA Rating Table










80-100
A



More than 0-Less than 80
B



Not Tested
C



No activity noticed in this bioassay
D
















TABLE 1







Structures for Compounds








Compound



Number
Structure





AI34






 


AI36






 


AI37






 


AI38






 


AI39






 


AI40






 


AI41






 


AI44






 


AI45






 


AC1






 


AC2






 


AC3






 


AC4






 


AC5






 


AC6






 


AC7






 


AC8






 


AC9






 


AC10






 


AC11






 


AC12






 


AC13






 


AC14






 


AC15






 


AC16






 


AC17






 


AC18






 


AC19






 


AC20






 


AC21






 


AC22






 


AC23






 


AC24






 


AC25






 


AC26






 


AC27






 


AC28






 


AC29






 


AC30






 


AC31






 


AC32






 


AC33






 


AC34






 


AC35






 


AC36






 


AC37






 


AC38






 


AC39






 


AC40






 


AC41






 


AC42






 


AC43






 


AC44






 


AC45






 


AC46






 


AC47






 


AC48






 


AC49






 


AC50






 


AC51






 


AC52






 


AC53






 


AC54






 


AC57






 


AC58






 


AC59






 


AC60






 


AC61






 


AC62






 


AC63






 


AC64






 


AC65






 


AC66






 


AC67






 


AC68






 


AC69






 


AC70






 


AC71






 


AC72






 


AC75






 


AC76






 


AC77






 


AC78






 


AC79






 


AC80






 


AC81






 


AC82






 


AC83






 


AC84






 


AC85






 


AC86






 


AC87






 


AC89






 


AC90






 


AC91






 


AC92






 


AC93






 


AC94






 


AC95






 


AC96






 


AC97






 


AC98






 


AC99






 


AC100






 


AC101






 


AC102






 


AC103






 


AC104






 


AC105






 


AC106






 


AC107






 


AC108






 


AC109






 


AC110






 


AC111






 


AC112






 


AC113






 


AC114






 


AC115






 


AC116






 


AC117






 


AC118






 


BC1






 


BC2






 


BC3






 


BC4






 


BC5






 


BC6






 


BC7






 


BC8






 


BC9






 


BC10






 


BC11






 


BC12






 


BC13






 


BC14






 


CI4






 


CI5






 


CI8






 


CI9






 


CI34






 


CI35






 


CI36






 


CI37






 


CI38






 


CI39






 


CI40






 


CI41






 


CI49






 


CI50






 


CI51






 


CI52






 


CI53






 


CI54






 


CI55






 


CI56






 


CI57






 


CC1






 


CC2






 


CC3






 


CC4






 


CC5






 


CC6






 


CC7






 


CC8






 


CC9






 


CC10






 


CC11






 


CC12






 


CC13






 


CC14






 


CC15






 


CC16






 


CC17






 


CC18






 


CC19






 


CC20






 


CC21






 


CC22






 


CC23






 


CC24






 


CC25






 


CC26






 


CC27






 


CC28






 


CC29






 


CC30






 


CC31






 


CC32






 


CC33






 


CC34






 


CC35






 


CC36






 


CC37






 


CC38






 


CC39






 


CC40






 


CC41






 


CC42






 


CC43






 


CC44






 


CC45






 


CC46






 


CC47






 


CC48






 


CC49






 


CC50






 


CC51






 


CC52






 


CC53






 


CC54






 


DC1






 


DC2






 


DC3






 


DC4






 


DC5






 


DC6






 


DC7






 


DC8






 


DC9






 


DC10






 


DC11






 


DC12






 


DC13






 


DC14






 


DC15






 


DC16






 


DC17






 


DC18






 


DC19






 


DC20






 


DC21






 


DC22






 


DC23






 


DC24






 


DC25






 


DC26






 


DC27






 


DC28






 


DC29






 


DC30






 


DC31






 


DC32






 


DC33






 


DC34






 


DC35






 


DC36






 


DC37






 


DC38






 


DC39






 


DC40






 


DC41






 


DC42






 


DC43






 


DC44






 


DC45






 


DC46






 


DC47






 


DC48






 


DC49






 


DC50






 


DC51






 


DC52






 


DC53






 


DC54






 


DC55






 


DC56






 


DC57






 


DC58






 


DC59






 


DC60






 


DC61






 


DC62






 


DC63






 


DC64






 


DC65






 


DC66






 


DC67






 


DC68






 


DC69






 


DC70




















TABLE 1A







Structures for F Compounds










Compound


Prepared as


Number
Structure
Appearance
in Example:













F1




white foam
135


 


F2




brown gum
15


 


F3




pale yellow gum
15


 


F4




yellow solid
15


 


F5





108


 


F6





108


 


F7




yellow solid
15


 


F8




off-white solid
15


 


F8A




pale yellow solid
15


 


F9




yellow solid
15


 


F10




off-white solid
132


 


F11




off-white solid
132


 


F12




off-white solid
133


 


F13




off-white solid
133


 


F14




pale yellow solid
15


 


F15




yellow solid
15


 


F15A




yellow solid
15


 


F16




pale yellow solid
15


 


F16A




yellow solid
15


 


F17




off-white solid
15


 


F18




yellow solid
15


 


F19




yellow gum
15


 


F20




yellow solid
15


 


F20A




off-white solid
133


 


F20B




off-white solid
133


 


F20C




white solid
88


 


F21




yellow gum
15


 


F22




light brown gum
15


 


F23




pale yellow liquid
15


 


F23A




yellow solid
15


 


F24




pale yellow liquid
15


 


F25




yellow solid
15


 


F26




brown gum
15


 


F27




pale yellow gum
15


 


F28




brown gum
15


 


F29




pale yellow gum
19


 


F30




brown gum
15


 


F31




pale yellow gum
134
















TABLE 1B







Structures of Prophetic Compounds Subsequently Exemplified










Compound


Prepared as


Number
Structure
Appearance
in Example:













P1




Yellow solid
15


 


P2




Brown gum
15


 


P12




Off white solid
15


 


P14




Light yellow gum
19


 


P15




Light yellow gum
19


 


P82




Brown semi solid
15


 


P84




Pale yellow solid
15


 


P156




Green liquid
15


 


P226




Brown semi solid
15


 


P228




Brown semi solid
15


 


P298




Yellow solid
15


 


P300




Brown gum
15


 


P442




Pale yellow solid
15


 


P444




Pale yellow solid
15


 


P514




Off white solid
15


 


P516




Brown solid
15


 


P568




Brown semi solid
15


 


P586




Brown semi solid
15


 


P588




Brown semi solid
15


 


P660




Pale yellow solid
15


 


P730




Yellow solid
15


 


P732




Brown semi solid
15


 


P802




Brown gum
15


 


P804




Brown gum
15


 


P1090




Light brown solid
15


 


P1092




Brown semi solid
15


 


P1197




Off white solid
15


 


P1269




Pale yellow solid
15


 


P1340




Pale yellow liquid
15


 


P1411




Pale yellow liquid
15


 


P1483




Off white solid
15


 


P1556




Brown solid
15


 


P1558




Brown solid
134


 


P1559




Brown gum
134


 


P1560




Off white solid
19


 


P1564




Yellow solid
19


 


P1566




Brown solid
15


 


P1589




Pale yellow gum
15


 


P1591




Brown gum
15


 


P1592




Pale yellow gum
15


 


P1599




Brown semi solid
12


 


P1601




Brown viscous liquid
15


 


P1603




Off white solid
135


 


P1611A




Pale yellow solid
137


 


P1613A




Brown solid
137


 


P1616




Brown gum
15


 


P1616A




Pale yellow semi solid
137


 


P1618A




Brown solid
137


 


P1621




Brown viscous liquid
12


 


P1623




Brown liquid
12


 


P1624




Brown semi solid
12


 


P1631A




Brown viscous liquid
137


 


P1633A




Brown solid
137


 


P1636




Off white solid
135


 


P1638




Pale yellow solid
15


 


P1640




Brown semi solid
15


 


P1641




Brown solid
15


 


P1691




Brown gum
15


 


P1693




Pale yellow semi solid
15


 


P1696




Yellow solid
15


 


P1698




Yellow semi solid
15


 


P1776




White solid
15


 


P1781




White solid
15


 


P1806




Brown gum
15


 


P1808




Pale yellow gum
15


 


P1862




Off white gum
15


 


P1864




Brown gum
19


 


P1866




Brown liquid
19


 


P1969




Brown solid
15


 


P1970




Brown gum
15


 


P1971




Pale yellow solid
15


 


P1972




Light brown solid
15


 


P2009




Yellow solid
15


 


P2010




Yellow gum
15


 


P2011




Yellow solid
15


 


P2012




Off white solid
15


 


P2036




Brown solid
15


 


P2038




Yellow liquid
15


 


P2041




Brown solid
15


 


P2043




Dark green solid
15


 


P2056




Brown solid
15


 


P2058




Pale yellow semi solid
15
















TABLE 1C







Structures for FA Compounds













Prepared as


Compound


in


Number
Structure
Appearance
Example:













FA1




Pale yellow gum
15


 


FA2




Light green liquid
15


 


FA3




Brown gum
15


 


FA4




White foam
138


 


FA5




White foam
138


 


FA6




Yellow solid
146


 


FA7




Pale yellow solid
137


 


FA8




Pale yellow gum
15


 


FA9




Yellow gum
134


 


FA10




Yellow gum
134


 


FA11




Brown semi solid
134


 


FA12




Brown semi solid
134


 


FA13




Light green solid
147


 


FA14




White foam
142


 


FA15




White foam
142


 


FA16




Pale yellow solid
15


 


FA17




Off white solid
15


 


FA18




Yellow semi solid
15


 


FA19




Pale yellow solid
15


 


FA20




Pale yellow solid
15


 


FA21




Brown gum
15


 


FA22




Yellow gum
15


 


FA23




Light yellow oil
142


 


FA24




Off white solid
15


 


FA25




Yellow solid
15


 


FA26




Light green solid
12


 


FA27




Pale green solid
12


 


FA28




Brown solid
15


 


FA29




Brown liquid
15


 


FA30




Brown gum
12


 


FA31




Pale yellow solid
12


 


FA32




Yellow solid
15


 


FA33




Yellow solid
135


 


FA34




Off white solid
149
















TABLE 2







Analytical Data for Compounds in Table 1.











Compound
mp





Number
(° C.)
ESIMS
1H NMR (δ)a
IR (cm−1)





AC1
156-161
386.09 ([M − H]−)
7.83 (m, 2H),






7.68-7.63 (m, 5H), 6.93 (dd, J = 15.6,






8.0 Hz, 1H),






6.81 (d J = 15.6 Hz, 1H,),






4.15 (m, 1H), 2.80 (s,






3H)



AC2
110-112
374 ([M + H]+)
7.80 (d, J = 8.4 Hz, 2H),






7.48 (d, J = 8.0 Hz, 2H),






7.38 (m, 1H), 7.30 (s,






2H), 6.65 (d, J = 16.0 Hz,






1H), 6.46 (dd, J = 16.0,






8.0 Hz, 1H),






4.15 (m, 1H)



AC3
162-166
402.24 ([M + H]+)
7.42 (m, 4H), 7.37 (t, J = 1.8 Hz,






1H), 7.28 (s,






2H), 6.63 (d, J = 16.0 Hz,






1H), 6.41 (dd, J = 16.0,






8.4 Hz, 1H),






4.15 (m, 1H), 3.20 (s, 3H),






3.00 (s, 3H)



AC4
122-126
454 ([M − H]−)
7.79 (d, J = 1.2 Hz, 2H),






7.48 (d, J = 8.4 Hz, 2H),






7.38 (t, J = 1.8 Hz, 1H),






7.30 (s, 2H), 6.64 (d, J = 15.6 Hz,






1H), 6.40 (dd,






J = 15.6, 8.0 Hz, 1H),






6.30 (m, 1H), 4.15 (m,






3H)



AC5

444.12 ([M + H]+)
7.67 (s, 3H), 7.64 (d, J = 8.0 Hz,






2H), 7.42 (d, J = 8.0 Hz,






2H), 6.91 (dd, J = 15.6,






8.0 Hz, 1H),






6.80 (d, J = 15.6 Hz,






1H), 4.80 (m, 1H),






3.60 (br s, 8H)



AC6

468.40 ([M − H]−)
7.40 (m, 2H), 7.26 (m,
1657, 1113,





3H), 6.56 (d, J = 16.0 Hz,
804





1H), 6.48 (dd, J = 16.0,






8.0 Hz, 1H),






5.82 (br s, 1H), 4.08 (m, 3H),






2.52 (s, 3H)



AC7

511.02 ([M − H]−)
8.39 (s, 1H), 7.74 (m,
3276, 1645,





1H), 7.39 (m, 3H),
1111, 801





7.24 (m, 4H), 6.58 (d, J = 16.0 Hz,






1H), 6.38 (dd,






J = 16.0, 8.0 Hz, 1H),






6.16 (br s, 1H), 4.63 (m,






2H), 4.12 (m, 1H),






2.41 (s, 3H)



AC8

454.11 ([M − H]−)
7.39 (s, 1H), 7.22 (m,
1748, 1112,





2H), 7.19 (m, 3H),
801





6.53 (d, J = 16.0 Hz, 1H),






6.39-6.34 (dd, J = 16.0,






8.0 Hz, 1H), 4.22 (m,






1H), 3.95 (t, J = 7.0 Hz,






2H), 2.62 (t, J = 8.0 Hz,






2H), 2.30 (s, 3H),






2.18 (m, 2H)



AC9

494.02 ([M − H]−)
7.45 (t, J = 7.6 Hz, 1H),
3276, 1645,





7.36 (m, 2H), 7.21 (m,
1112, 801





3H), 7.15 (m, 4H),






6.56 (d, J = 16.0 Hz, 1H),






6.38 (dd, J = 16.0, 8.4 Hz,






1H), 6.08 (br s, 1H),






4.68 (d, J = 5.6 Hz, 2H),






4.11 (m, 1H), 2.44 (s,






3H)



A10
140-143
458.00 ([M − H]−)
7.38 (t, J = 1.6 Hz, 1H),






7.34 (d, J = 7.6 Hz, 1H),






7.27 (m, 2H), 7.24 (m,






2H), 6.57 (d, J = 16.0 Hz,






1H), 6.40 (dd, J = 16.0,






8.0 Hz, 1H),






6.16 (m 1H), 5.44 (m, 1H),






4.12 (m, 1H), 3.51 (m,






2H), 3.40 (m, 2H),






2.44 (s, 3H)



AC11

476.17 ([M − H]−)
7.39-7.29 (m, 9H),
3287, 1644,





7.24 (m, 2H), 6.56 (d, J = 16.0 Hz,
1112, 801





1H), 6.38 (dd,






J = 16.0, 8.0 Hz, 1H),






5.99 (br s, 1H), 4.63 (d,






J = 6.0 Hz, 1H),






4.11 (m, 1H), 2.47 (s, 3H)



AC12

479.30 ([M + H]+)
8.63 (d, J = 4.4 Hz, 1H),
3293, 1653,





7.71 (m, 1H), 7.47 (d, J = 8.4 Hz,
1112, 800





1H), 7.37 (m,






2H), 7.32 (m, 2H),






7.23 (m, 2H), 7.13 (m, 1H),






6.58 (d, J = 16.0 Hz,






1H), 6.40 (dd, J = 16.0,






8.0 Hz, 1H), 4.75 (d, J = 4.8 Hz,






2H), 4.12 (m,






1H), 2.49 (s, 3H)



AC13
75-78
490.04 ([M − H]−)
7.38 (m, 2H), 7.27 (m,






3H), 7.23 (br s, 1H),






6.58 (d, J = 16.0 Hz,






1H), 6.45 (m 1H),






6.42 (dd, J = 16.0, 8.4 Hz,






1H), 4.91 (m 1H),






4.64 (m, 2H), 4.14 (m, 1H),






4.04 (m, 2H), 2.46 (s,






3H)



AC14

480.99 ([M + 2H]+)
8.63 (s, 2H), 7.76 (d, J = 8.0 Hz,
3293, 1645,





1H), 7.36 (m,
1113, 800





3H), 7.22 (m, 1H),






7.13 (m, 2H), 6.57 (d, J = 16.0 Hz,






1H), 6.39 (dd,






J = 16.0, 8.0 Hz, 1H),






6.13 (br s, 1H), 4.66 (d,






J = 5.6 Hz, 2H),






4.11 (m, 1H), 2.46 (s, 3H)



AC15
59-61
516.86 ([M − H]−)
7.45 (s, 1H), 7.37 (m,
3246, 1635,





1H), 7.34 (m, 1H),
1112, 801





7.26 (m, 3H), 7.22 (m, 1H),






6.57 (d, J = 16.0 Hz,






1H), 6.40 (dd, J = 16.0,






8.0 Hz, 1H), 6.18 (m,






1H), 4.71 (d, J = 6.4 Hz,






2H), 4.11 (m, 1H),






2.46 (s, 3H)



AC16

506.93 ([M + H]+)
8.47 (m, 1H), 8.19 (s,
1657, 1113,





1H), 7.76 (m, 1H),
801





7.47 (m, 2H), 7.37 (m, 1H),






7.28 (m, 2H), 7.24 (m,






1H), 7.21 (m, 1H),






6.59 (d, J = 16.0 Hz, 1H),






6.39 (dd, J = 16.0, 8.4 Hz,






1H), 4.12 (m, 1H),






2.48 (s, 3H), 1.88 (s,






6H)



AC17
70-73
494.98 ([M − H]−)
7.49 (m, 2H), 7.38 (m,






1H), 7.29 (m, 4H),






7.08 (m, 3H), 6.91 (m, 1H),






6.61 (d, J = 16.0 Hz,






1H), 6.48 (m, 1H),






6.43 (dd, J = 16.0, 8.0 Hz,






1H), 4.13 (m, 1H),






2.49 (s, 3H)



AC18
155-158
480.44 ([M + H]+)
8.73 (d, J = 4.8 Hz, 2H),






7.53 (d, J = 8.4 Hz, 1H),






7.37 (m, 1H), 7.27 (m,






4H), 7.23 (m, 1H),






7.11 (m, 1H), 6.60 (d, J = 16.0 Hz,






1H), 6.41 (dd,






J = 16.0, 8.0 Hz, 1H),






4.90 (d, J = 4.8 Hz, 2H),






4.13 (m, 1H), 2.52 (s,






3H)



AC19
55-57
471.66 ([M + H]+)
7.37 (m, 1H), 7.33 (d, J = 7.6 Hz,






1H), 7.27 (m,






2H), 7.22 (m, 2H),






6.57 (d, J = 16.0 Hz, 1H),






6.39 (dd, J = 16.0, 8.0 Hz,






1H), 6.10 (brs, 1H),






4.13 (m, 2H), 3.94 (m,






1H), 3.79 (m, 2H),






3.35 (m, 1H), 2.45 (s, 3H),






2.14 (m, 1H), 1.71 (m,






2H), 1.65 (m, 1H).



AC20

467.68 ([M + H]+)
7.37 (m, 2H), 7.27 (m,
3437, 1664,





2H), 7.23 (m, 2H),
1265, 1114,





6.57 (d, J = 16.0 Hz, 1H),
746





6.38 (m, 3H), 6.01 (m,






1H), 4.63 (d, J = 5.6 Hz,






2H), 4.13 (m, 1H),






2.45 (s, 3H)



AC21
61-64
528.78 ([M + H]+)
8.44 (s, 1H), 8.18 (s,






1H), 7.83 (br s, 1H),






7.38 (m, 2H), 7.27 (m,






2H), 7.25 (m, 2H),






7.21 (m, 1H), 6.57 (d, J = 16.0 Hz,






1H), 6.40 (dd,






J = 16.0, 8.0 Hz, 1H),






5.01 (s, 2H), 4.11 (m,






1H), 2.43 (s, 3H)



AC22

545.08 ([M − H]−)
8.39 (s, 1H), 7.73 (m,
3270, 1642,





1H), 7.40 (s, 1H),
1111, 809





7.35 (m, 2H), 7.22 (m, 3H),






6.57 (d, J = 16.0 Hz,






1H), 6.38 (dd, J = 16.0,






7.6 Hz, 1H), 6.14 (br s,






1H), 4.62 (d, J = 6.0 Hz,






2H), 4.13 (m, 1H),






2.45 (s, 3H)



AC23

492.35 ([M − H]−)
7.42 (s, 2H), 7.36 (m,
3273, 1641,





1H), 7.24 (m, 2H),
1250, 1113,





6.59 (d, J = 16.0 Hz, 1H),
807





6.40 (dd, J = 16.0, 8.0 Hz,






1H), 6.20 (br s, 1H),






5.46 (m, 1H), 4.15 (m,






1H), 3.52 (m, 2H),






3.41 (m, 2H), 2.45 (s, 3H)



AC24
129-132
526.98 ([M + H]+)
7.40 (m, 2H), 7.27 (m,
3298, 1664,





2H), 7.25 (m, 2H),
1113, 803





6.92 (br s, 2H), 6.60 (m, 1H),






6.48 (dd, J = 16.0, 8.0 Hz,






1H), 4.19 (d, J = 5.2,






2H), 4.08 (m, 1H),






3.99 (m, 2H), 2.46 (s,






3H)



AC25

542.24 ([M − H]−)
7.41 (m, 3H), 7.27 (m,
3257, 1652,





2H), 6.58 (d, J = 15.6 Hz,
1316, 1109,





1H), 6.42 (m, 2H),
807





4.92 (m, 1H), 4.65 (m,






2H), 4.14 (m, 1H),






4.09 (m, 2H), 2.46 (s, 3H)



AC26

550.69 ([M − H]−)
7.45 (s, 1H), 7.40 (s,
3255, 1638,





2H), 7.34 (d, J = 8.0 Hz,
1113, 809





1H), 7.22 (m, 2H),






6.54 (d, J = 16.0 Hz, 1H),






6.38 (dd, J = 16.0, 8.0 Hz,






1H), 4.71 (d, J = 6.0 Hz,






2H), 4.11 (m, 1H),






2.46 (s, 3H)



AC27

541.00 ([M − H]−)
8.46 (d, J = 4.0 Hz, 1H),
1653, 1113,





8.20 (s, 1H), 7.76 (m,
809





1H), 7.47 (m, 2H),






7.41 (s, 2H), 7.23 (m, 2H),






7.21 (m, 1H), 6.59 (d, J = 16.0 Hz,






1H),






6.37 (dd, J = 16.0, 8.4 Hz,






1H), 4.11 (m, 1H),






2.48 (s, 3H), 1.88 (s, 6H)



AC28
65-67
564.84 ([M − H]−)
8.40 (s, 1H), 7.74 (m,
3267, 1650,





2H), 7.42 (m, 3H),
1112, 809





7.36 (m, 2H), 6.72 (br s, 1H),






6.52 (d, J = 16.0 Hz,






1H), 6.43 (dd, J = 16.0,






8.0 Hz, 1H), 4.66 (d, J = 6.4 Hz,






2H), 4.12 (m,






1H)



AC29
75-78
511.78 ([M − H]−)
7.71 (d, J = 8.4 Hz, 1H),






7.42 (m, 3H), 7.35 (m,






1H), 6.75 (br s, 1H),






6.56 (d, J = 16.0 Hz,






1H), 6.43 (dd, J = 16.0,






8.0 Hz, 1H), 5.49 (m,






1H), 4.14 (m, 1H),






3.50 (m, 4H)



AC30
110-113
543.72 ([M − H]−)
7.42 (d, J = 8.4 Hz, 1H),






7.44 (s, 1H), 7.40 (s,






1H), 7.38 (m, 1H),






7.06 (br s, 1H), 6.58 (d, J = 15.6 Hz,






1H), 6.45 (dd,






J = 15.6, 8.0 Hz, 1H),






4.93 (m, 1H), 4.65 (m,






2H), 4.13 (m, 3H)



AC31
68-70
610.73 ([M + H]+)
8.42 (s, 1H), 7.76 (m,






1H), 7.61 (m, 2H),






7.39 (m, 4H), 6.54-6.39 (m,






3H), 4.66 (d, J = 6.0 Hz,






2H), 4.12 (m, 1H)



AC32
78-80
555.89 ([M − H]−)
7.61 (m, 2H), 7.40 (m,






3H), 6.54 (m, 2H),






6.40 (dd, J = 16.0, 8.0 Hz,






1H), 5.46 (m, 1H),






4.14 (m, 1H), 3.50 (m, 4H)



AC33
182-184
587.68 ([M − H]−)
7.62 (s, 1H), 7.58 (d, J = 8.0 Hz,






1H), 7.40 (m,






3H), 6.84 (br s, 1H),






6.55 (d, J = 15.6 Hz,






1H), 6.45 (dd, J = 15.6,






7.6 Hz, 1H), 4.93 (m






1H), 4.65 (m, 2H),






4.13 (m, 4H)



AC34
151-153
545.83 ([M − H]−)
7.67 (s, 1H), 7.61 (d, J = 6.0 Hz,






1H), 7.53 (m,






1H), 7.41 (s, 2H),






6.64 (d, J = 16.0 Hz, 1H),






6.40 (dd, J = 16.0, 8.0 Hz,






1H), 6.18 (br s, 1H),






5.44 (m, 1H), 4.14 (m,






1H), 3.50 (m, 2H),






3.40 (m, 2H)



AC35
100-102
577.71 ([M − H]−)
7.70 (s, 1H), 7.63 (m,
3257, 1655,





1H), 7.53 (d, J = 7.6 Hz,
1113, 808





1H), 7.41 (s, 2H),






6.53 (d, J = 16.0 Hz, 1H),






6.49 (m, 2H), 4.93 (m,






1H), 4.64 (m, 2H),






4.13 (m, 1H), 4.03 (m, 2H)



AC36
81-83
600.83 ([M + H]+)
8.40 (s, 1H), 7.73 (m,






2H), 7.61 (d, J = 8.4 Hz,






1H), 7.52 (d, J = 8.0 Hz,






1H), 7.40 (s, 2H),






7.35 (d, J = 8.0 Hz, 1H),






6.63 (d, J = 16.0 Hz, 1H),






6.46 (dd, J = 16.0, 7.6 Hz,






1H), 6.14 (m, 1H),






4.63 (d, J = 6.0 Hz, 2H),






4.14 (m, 1H)



AC37

512.68 ([M + H]+)
8.39 (s, 1H), 7.73 (m,
3268, 1644,





1H), 7.48 (m, 2H),
1109, 820





7.34 (d, J = 7.6 Hz, 1H),






7.24 (m, 3H), 6.55 (d, J = 16.0 Hz,






1H), 6.41 (dd,






J = 16.0, 7.6 Hz, 1H),






6.12 (m, 1H), 4.62 (d, J = 6.0 Hz,






2H), 4.13 (m,






1H), 2.45 (s, 3H)



AC38
79-80
528.85 ([M − H]−)
8.46 (m, 1H), 7.73 (m,






1H), 7.35 (m, 4H),






7.22 (m, 2H), 6.56 (d, J = 16.0 Hz,






1H), 6.38 (dd,






J = 16.0, 8.0 Hz, 1H),






4.62 (d, J = 6.0 Hz, 2H),






4.10 (m, 1H), 2.45 (s,






3H)



AC39
141-144
477.83 ([M − H]−)
9.19 (s, 1H), 8.79 (s,






2H), 7.37 (m, 2H),






7.23 (m, 2H), 7.21 (m, 1H),






6.57 (d, J = 16.0 Hz,






1H), 6.40 (dd, J = 16.0,






7.6 Hz 1H), 6.21 (m,






1H), 4.65 (s, 2H),






4.11 (m, 1H), 2.46 (s, 3H)



AC40
69-72
484.67 ([M + H]+)
8.33 (t, J = 5.6 Hz, 1H),






8.61 (m, 1H), 7.68 (m,






3H), 7.48 (m, 2H),






6.86 (dd, J = 15.6, 8.2 Hz






1H), 6.74 (d, J = 15.6 Hz,






1H), 4.44 (m, 1H),






3.76 (d, J = 6.0 Hz, 2H),






2.54 (m, 1H), 2.67 (s,






3H), 0.59 (m, 2H),






0.54 (m, 2H)



AC41
196-199
515.00 ([M − H]−)
8.66 (d, J = 7.6 Hz,






1H), 8.39 (t, J = 5.6 Hz,






1H), 7.65 (s, 3H),






7.45 (m, 3H), 6.86 (dd, J = 15.6,






8.8 Hz, 1H),






6.74 (d, J = 15.6 Hz, 1H),






5.01 (m, 1H), 4.99 (m,






1H), 3.78 (d, J = 6.0 Hz,






2H), 3.40 (m, 2H),






3.22 (m, 2H), 2.37 (m,






3H)



AC42
79-82
534.72 ([M + H]+)
7.99 (d, J = 8.0 Hz,






1H), 7.89 (d, J = 8.0 Hz,






1H), 7.51 (m, 2H),






7.44 (m, 2H), 7.27 (m,






4H), 6.71 (t, J = 5.2 Hz,






1H), 6.59 (d, J = 16.0 Hz,






1H), 6.41 (dd, J = 16.0,






8.0 Hz, 1H),






5.05 (d, J = 1.6 Hz, 2H),






4.12 (m, 1H), 2.52 (m,






3H)



AC43

481.75 ([M + H]+)
8.69 (s, 1H), 8.52 (s,
1663,





2H), 7.45 (d, J = 7.6 Hz,
1608, 1168,





1H), 7.37 (d, J = 2.0 Hz,
1114, 801





1H), 7.26 (m, 2H),






7.21 (m, 1H), 6.83 (s, 1H),






6.58 (d, J = 16.0 Hz,






1H), 6.40 (dd, J = 16.0,






8.4 Hz, 1H), 4.81 (d, J = 5.6 Hz,






2H), 4.12 (t, J = 8.4 Hz






1H), 2.45 (s, 3H)



AC44

528.01 ([M + H]+)
8.44 (d, J = 2.4 Hz, 1H),
1640, 1166,





7.69 (d, J = 2.4 Hz,
1112, 800





1H), 7.37 (m, 1H),






7.33 (s, 1H), 7.31 (s, 1H),






7.26 (m, 1H), 7.24 (m,






3H), 6.57 (d, J = 16.0 Hz,






1H), 6.39 (dd, J = 16.0,






8.0 Hz, 1H),






5.96 (d, J = 7.2 Hz, 1H),






5.32 (t, J = 7.2 Hz, 1H),






4.11 (t, J = 8.4 Hz, 1H),






2.41 (s, 3H), 1.61 (d, J = 7.2 Hz,






3H)



AC45

512.88 ([M + H]+)
7.66 (s, 1H), 7.37 (d, J = 6.8 Hz,
1657, 1167,





2H), 7.26 (m,
1106, 800





3H), 7.18 (m, 1H),






7.11 (m, 2H), 6.99 (m, 1H),






6.57 (d, J = 15.6 Hz,






1H), 6.39 (dd, J = 15.6,






8.0 Hz, 1H), 4.11 (t, J = 8.4 Hz,






1H), 3.36 (s,






3H), 2.43 (s, 3H)



AC46
61-64
575.93 ([M + H]+)
8.42 (d, J = 2.0 Hz, 1H),






7.76 (d, J = 2.4 Hz, 1H),






7.61 (m, 2H), 7.39 (m,






3H), 7.26 (s, 2H),






6.54 (d, J = 16.0 Hz, 1H),






6.42 (dd, J = 16.0, 7.6 Hz,






1H), 4.65 (d, J = 6.0 Hz,






2H), 4.14 (m, 1H)



AC47

525.89 ([M − H]−)
10.02 (s, 1H), 9.87 (s,
3280, 1640





1H), 8.47 (t, J = 6.0 Hz,






1H), 7.66 (s, 3H),






7.44 (s, 1H), 7.40 (d, J = 3.6 Hz,






2H), 6.86 (dd, J = 15.6,






9.2 Hz, 1H),






6.74 (d, J = 15.6 Hz, 1H),






4.82 (t, J = 9.6 Hz, 2H),






3.88 (d, J = 6.0 Hz, 2H),






2.36 (s, 3H), 1.63 (m,






1H), 0.76 (m, 4H)



AC48

509.96 ([M − H]−)
7.37 (m, 7H), 7.34 (m,
3275, 1642





3H),, 6.57 (d, J = 16.0 Hz,






1H), 6.39 (dd, J = 16.0,






8.0 Hz, 1H),






6.01 (m, 1H), 4.60 (d, J = 6.0 Hz,






2H), 4.13 (m, 1H),






2.46 (s, 3H)



AC49

518.85 ([M + H]+)
8.39 (d, J = 2.0 Hz, 1H),
1658, 1112,





8.11 (m, 1H), 7.71 (d, J = 2.4 Hz,
1025, 2219





1H), 7.41 (m,






3H), 7.17 (m, 3H),






6.59 (d, J = 16.0 Hz, 1H),






6.47 (dd, J = 16.0, 8.0 Hz,






1H), 4.66 (d, J = 5.6 Hz,






2H), 4.14 (m,






1H)



AC50

481.88 ([M + H]+)
8.72 (m, 1H), 7.67 (s,
1654, 1112,





3H), 7.46 (s, 1H),
800, 3069





7.40 (m, 2H), 7.08 (s, 1H),






6.82 (m, 2H), 6.55 (d, J = 7.6 Hz,






1H), 4.82 (m,






1H), 4.48 (s, 2H),






3.65 (s, 3H), 2.38 (s, 3H)



AC51

540.83 ([M + H]+)
7.45 (d, J = 7.6 Hz, 1H),
1652, 1571,





7.38 (m, 1H), 7.27 (m,
802, 1114,





2H), 7.22 (m, 2H),
2926





6.85 (m, 1H), 6.58 (d, J = 16.0 Hz,






1H), 6.40 (dd,






J = 16.0, 8.0 Hz, 1H),






4.33 (m, 2H), 4.14 (m,






3H), 3.18 (s, 3H),






2.48 (s, 3H)



AC52

488.29 ([M − H]−)
7.33 (m, 2H), 7.25 (m,
1635, 11134,





3H), 6.56 (d, J = 15.6 Hz,
813, 2927





1H), 6.37 (dd, J = 15.6,






8.0 Hz, 1H),






5.61 (d, J = 8.0 Hz, 1H),






4.21 (m, 1H), 4.01 (m, 1H),






4.08 (m, 2H), 3.56 (t, J = 10.0 Hz,






2H), 2.48 (m,






2H), 2.08 (m, 2H),






1.5 (m, 3H)



AC53

532.92 ([M + H]+)
8.49 (d, J = 2.0 Hz, 1H),
1651, 3027,





7.69 (d, J = 2.4 Hz, 1H),
815, 1113





7.43 (d, J = 8.0 Hz, 1H),






7.34 (m, 3H), 7.26 (m,






2H), 6.95 (m, 1H),






6.58 (d, J = 16.0 Hz, 1H),






6.38 (dd, J = 16.0, 8.0 Hz,






1H), 4.72 (d, J = 5.2 Hz,






2H), 4.09 (m, 1H),






2.47 (s, 3H)



AC54

529.06 ([M − H]−)
8.37 (d, J = 5.2 Hz, 1H),
1654, 3434,





7.41 (d, J = 8.0 Hz, 1H),
814, 1112





7.36 (m, 3H), 7.31 (m,






1H), 7.26 (m, 2H),






6.58 (d, J = 16.0 Hz, 1H),






6.40 (dd, J = 16.0, 7.6 Hz,






1H), 5.20 (t, J = 5.6 Hz,






1H), 4.63 (d, J = 6.0 Hz,






2H), 4.13 (m, 1H),






2.18 (s, 3H)



AC57

464.96 ([M + H]+)
8.69 (t, J = 6.0 Hz, 1H),
3417, 1658,





8.58 (t, J = 6.0 Hz, 1H),
1165, 817





7.92 (s, 1H), 7.87 (d, J = 6.4 Hz,






2H), 7.62 (d, J = 8.4 Hz,






1H), 7.45 (d, J = 8.4 Hz,






1H), 7.0 (m,






1H), 6.76 (d, J = 15.6 Hz,






1H), 6.76 (dd, J = 15.6,






8.0 Hz, 1H),






4.01 (m, J = 8.0 Hz, 1H),






3.71 (m, 2H), 3.49 (m,






2H)



AC58
124.4-126.9
599.76 ([M + H]+)
7.62 (m, 2H), 7.40 (s,






2H), 7.37 (d, J = 1.6 Hz,






1H), 6.61 (t, J = 4.8 Hz,






1H), 6.55 (d, J = 16.0 Hz,






1H), 6.41 (dd, J = 16.0,






7.6 Hz, 1H),






4.16 (d, J = 6.0 Hz, 2H),






4.01 (m, 1H), 1.56 (s, 9H)



AC59
80-83
497.40 ([M − H]−)
8.42 (d, J = 2.1 Hz, 1H),






8.29 (d, J = 7.5 Hz, 1H),






7.51 (m, 2H), 7.39 (m,






1H), 7.36 (m, 4H),






7.28 (m, 1H), 6.61 (d, J = 15.9 Hz,






1H), 6.45 (dd,






J = 15.9, 7.8 Hz 1H),






4.14 (t, J = 8.4 Hz, 1H),






2.51 (s, 3H)



AC60

515.09 ([M + H]−)
8.52 (s, 1H), 8.39 (d, J = 1.8 Hz,
1668, 1589,





2H), 7.70 (d, J = 2.1 Hz,
1167, 1113,





1H), 7.62 (s,
802





1H), 7.43 (s, 1H),






7.35 (m, 3H), 6.62 (d, J = 16.2 Hz,






1H), 6.52 (dd,






J = 16.2, 7.5 Hz, 1H),






4.62 (d, J = 6.3 Hz,






2H), 4.19 (m, 1H),






2.76 (s, 3H)



AC61

461.90 ([M − H]−)
8.07 (t, J = 8.0 Hz, 1H),
1658, 1114,





7.39 (t, J = 2.0 Hz, 1H),
801





7.28 (d, J = 1.2 Hz, 3H),






7.17 (d, J = 1.6 Hz, 1H),






7.11 (m, 1H), 6.59 (d, J = 15.6 Hz,






1H),






6.47 (dd, J = 15.6, 7.6 Hz,






1H), 5.49 (m, 1H),






4.14 (t, J = 8.4 Hz, 1H),






3.48 (m, 4H)



AC62
105-108
528.88 ([M − H]−)
8.62 (t, J = 6.4 Hz, 1H),






8.46 (m, 1H), 7.73 (m,






5H), 7.48 (d, J = 7.6 Hz,






1H), 7.03 (dd, J = 15.6,






9.2 Hz, 1H), 6.81 (d, J = 15.6 Hz,






1H), 4.86 (m,






1H), 3.97 (m, 4H)



AC63
77-80
594.67 ([M + H]+)
8.43 (s, 1H), 7.76 (d, J = 2.4 Hz,
3257, 1653





1H), 7.60 (m,






2H), 7.38 (d, J = 7.6 Hz,






1H), 7.33 (d, J = 6.4 Hz,






3H), 6.54 (d, J = 16.0 Hz,






1H), 6.46 (m, 1H),






6.41 (dd, J = 16.0 8.0 Hz,






1H), 4.65 (d, J = 6.0 Hz,






2H), 4.15 (m, 1H)



AC64
83-85
580.72 ([M − H]−)
7.72 (d, J = 8.0 Hz, 1H),






7.44 (s, 1H), 7.40 (s,






2H), 7.36 (d, J = 6.8 Hz,






1H), 7.05 (t, J = 5.2 Hz,






1H), 6.70 (t, J = 5.2 Hz,






1H), 6.57 (d, J = 15.6 Hz,






1H), 6.44 (dd, J = 15.6,






8.0 Hz, 1H),






4.23 (d, J = 5.6 Hz, 2H),






4.15 (m, 1H), 4.01 (m, 2H)



AC65

534.72 ([M − H]−)
8.39 (d, J = 2.0 Hz,
1658, 1113,





1H), 8.12 (t, J = 8.4 Hz,
817, 2925





1H), 7.71 (d, J = 2.4 Hz,






1H), 7.34 (m, 3H),






7.26 (m, 1H), 7.11 (m, 2H),






6.59 (d, J = 16.0 Hz,






1H), 6.46 (dd, J = 16.0,






8.0 Hz, 1H), 4.66 (d, J = 5.2 Hz,






2H), 4.13 (m,






1H)



AC66
73-75
624.61 ([M − H]−)
7.88 (s, 1H), 7.63 (d, J = 1.6 Hz,






1H), 7.57 (d, J = 8.0 Hz,






1H), 7.40 (m,






2H), 6.80 (t, J = 5.6 Hz,






1H), 6.70 (t, J = 5.6 Hz,






1H), 6.56 (d, J = 16.0 Hz,






1H), 6.44 (dd, J = 16.0,






8.0 Hz, 1H),






4.22 (m, 2H), 4.12 (m, 1H),






4.01 (m, 2H)



AC67

479.82 ([M − H]−)
8.07 (t, J = 8.0 Hz, 1H),
3272, 1644





7.34 (d, J = 6.0 Hz, 2H),






7.28 (s, 1H), 7.17 (s,






2H), 6.59 (d, J = 15.6 Hz,






1H), 6.46 (dd, J = 15.6,






8.0 Hz, 1H),






5.49 (m, 1H),, 4.12 (m, 1H),






3.49 (m, 4H).



AC68
90-93
546.80 ([M − H]−)
8.6 (t, J = 6.4 Hz, 1H),
3315, 1684





8.45 (m, 1H), 7.86 (d, J = 6.4 Hz,






2H), 7.75 (t, J = 8.0 Hz,






1H), 7.63 (d, J = 12.0 Hz,






1H), 7.48 (d,






J = 8.0 Hz, 1H),






7.03 (dd, J = 15.6, 9.6 Hz,






1H), 6.80 (d, J = 15.6 Hz,






1H), 4.88 (m, 1H),






3.96 (m, 4H)



AC69

542.82 ([M − H]−)
7.41 (d, J = 8.0 Hz, 1H),
3294, 1685





7.34 (d, J = 5.6 Hz, 2H),






7.26 (m, 1H), 7.23 (m,






1H), 6.81 (s, 1H),






6.57 (d, J = 15.6 Hz, 1H),






6.55 (s, 1H), 6.39 (dd, J = 15.6,






8.0 Hz, 1H),






4.18 (m, 2H), 4.13 (m,






1H), 3.97 (m, 2H),






2.46 (s, 3H)



AC70
176-178
545.23 ([M − H]−)
8.38 (d, J = 2.4 Hz, 1H),






8.22 (d, J = 6.8 Hz, 2H),






7.71 (d, J = 2.4 Hz, 1H),






7.35 (d, J = 6.0 Hz, 2H),






7.30 (d, J = 7.6 Hz, 1H),






7.15 (d, J = 1.6 Hz, 1H),






6.93 (d, J = 1.2 Hz, 1H),






6.60 (d, J = 15.6 Hz,






1H), 6.43 (dd, J = 15.6,






7.6 Hz, 1H), 4.66 (d, J = 6.0 Hz,






2H), 4.13 (m,






1H), 3.98 (s, 3H)



AC71

492.20 ([M − H]−)
8.24 (d, J = 7.6 Hz, 1H),
1639, 3079,





8.15 (d, J = 8.4 Hz, 1H),
858





7.35 (d, J = 6.0 Hz, 2H),






7.13 (d, J = 1.2 Hz, 1H),






6.92 (s, 1H), 6.61 (d, J = 16.0 Hz,






1H), 6.43 (dd,






J = 16.0, 7.6 Hz, 1H),






5.48 (m, 1H), 4.13 (m,






1H), 4.03 (s, 3H),






3.48 (m, 4H)



AC72

543.05 ([M − H]−)
8.42 (d, J = 2.4 Hz, 1H),
1642, 3246,





7.75 (d, J = 2.4 Hz, 1H),
814, 1113





7.34 (m, 4H), 7.20 (m,






2H), 6.60 (d, J = 16.0 Hz,






1H), 6.36 (dd, J = 16.0,






8.0 Hz, 1H),






6.12 (t, J = 5.6 Hz, 1H),






4.62 (d, J = 6.0 Hz, 2H),






4.20 (m, 1H), 2.82 (m, 2H),






1.45 (t, J = 5.6 Hz, 3H)



AC75

644.78 ([M + H]+)
8.72 (s, 1H), 7.97 (d, J = 7.2 Hz,
3431, 1652,





1H), 7.70 (d, J = 8.4 Hz,
1171, 809





1H), 7.61 (m,






2H), 7.40 (m, 2H),






6.55 (m, 2H), 6.42 (dd, J = 16.0,






8.0 Hz, 1H),






4.76 (d, J = 6.0 Hz, 2H),






4.12 (m, 1H)



AC76

531.34 ([M + H]+)
8.87 (t, J = 6.0 Hz, 1H),
3120, 1708,





8.34 (d, J = 2.1 Hz, 1H),
1171





7.85 (d, J = 6.3 Hz, 3H),






7.48 (m, 4H), 6.57 (d, J = 15.6 Hz,






1H),






6.45 (dd, J = 15.6, 9.0 Hz,






1H), 4.84 (m, 1H),






4.49 (d, J = 5.7 Hz, 2H),






2.82 (m, 2H), 2.36 (t, J = 5.6 Hz,






3H)



AC77

531.1 ([M + H]+)
8.87 (t, J = 6.0 Hz, 1H),
3444, 1648,





8.34 (d, J = 2.1 Hz, 1H),
1114, 814





7.85 (d, J = 6.3 Hz, 3H),






7.48 (m, 4H), 6.57 (d, J = 15.6 Hz,






1H),






6.45 (dd, J = 15.6, 8.0 Hz,






1H), 4.84 (m, 1H),






4.49 (d, J = 5.7 Hz, 2H),






2.36 (s, 3H)



AC78

561.06 ([M + H]+)
8.59 (t, J = 6.4 Hz, 1H),
3432, 1631,





8.47 (t, J = 5.6 Hz, 1H),
1161, 840





7.89 (s, 2H), 7.45 (m,






3H), 6.87 (m, 1H),






6.75 (d, J = 15.6 Hz, 1H),






4.85 (t, J = 8.0 Hz 1H),






3.98 (m, 4H), 2.58 (s,






3H)



AC79

610.97 ([M + H]+)
8.69 (t, J = 6.0 Hz, 1H),
3303, 1658,





8.58 (t, J = 6.0 Hz, 1H),
1166, 817





7.92 (s, 1H), 7.87 (d, J = 6.4 Hz,






2H), 7.62 (d, J = 8.4 Hz,






1H), 7.45 (d, J = 8.4 Hz,






1H), 7.0 (m,






1H), 6.76 (d, J = 15.6 Hz,






1H) 4.83 (t, J = 8.0 Hz,






1H), 3.98 (m, 4H)



AC80

561.06 ([M + H]+)
7.37 (m, 3H), 7.26 (m,
3412, 1624,





1H), 7.24 (m, 1H),
1157, 825





6.59 (d, J = 15.6 Hz, 1H),






6.39 (dd, J = 15.6, 8.0 Hz,






1H), 4.24 (m, 4H),






3.90 (m, 1H), 2.83 (m,






2H), 1.26 (m, 3H)



AC81
 9-92
546.93 ([M − H]−)
8.73 (d, J = 5.6 Hz,






1H), 8.45 (t, J = 6.0 Hz,






1H), 7.76 (s, 3H),






7.45 (m, 3H), 6.86 (dd, J = 16.0,






9.2 Hz, 1H),






4.83 (m, 1H), 4.56 (m, 2H),






4.51 (m, 1H), 4.10 (m,






2H), 3.85 (d, J = 6.0 Hz,






2H), 2.50 (m, 3H)



AC82

477.69 ([M + H]+)
7.38 (d, J = 1.8 Hz,
1646, 1353,





2H), 7.33 (s, 1H),
1196, 1112,





7.27 (s, 3H), 6.58 (d, J = 16.0 Hz,
800





1H), 6.42 (d, J = 8.1 Hz,






1H), 6.36 (dd, J = 16.0,






7.8 Hz, 1H),






4.71 (m, 1H), 4.23 (m, 3H),






3.26 (m, 2H), 2.45 (s,






3H)



AC83

493.83 ([M − H]−)
8.07 (t, J = 8.4 Hz, 1H),
1527, 1113,





7.39 (t, J = 1.6 Hz, 1H),
801, 1167,





7.31 (d, J = 1.2 Hz, 1H),
1321





7.26 (m, 2H), 7.23 (m,






1H), 7.19 (d, J = 1.6 Hz,






1H), 6.60 (d, J = 16.8 Hz,






1H), 6.49 (dd, J = 16.8,






7.6 Hz, 1H),






4.90 (m, 1H), 4.64 (m, 2H),






4.14 (m, 2H), 4.10 (m,






1H)



AC84

511.75 ([M − H]−)
8.07 (t, J = 8.0 Hz, 1H),
1645, 1113,





7.34 (m, 3H), 7.19 (d, J = 13.2 Hz,
804, 3030,





1H), 6.60 (d,
1245





J = 16.4 Hz, 1H),






6.48 (dd, J = 16.4, 8.0 Hz,






1H), 4.88 (m, 1H),






4.62 (m, 2H), 4.12 (m, 3H)



AC85

523.83 ([M − H]−)
8.60 (d, J = 6.8 Hz, 1H),
1652, 3039,





8.15 (d, J = 8.4 Hz, 1H),
802, 1114





7.35 (d, J = 6.0 Hz, 1H),






7.15 (d, J = 7.2 Hz, 1H),






6.94 (s, 1H), 6.60 (d, J = 15.6 Hz,






1H), 6.44 (dd,






J = 7.6, 7.6 Hz, 1H),






4.93 (m, 1H), 4.62 (m,






2H), 4.13 (m, 6H)



AC86

524.36 ([M + H]+)
7.35 (d, J = 6.3 Hz, 3H),
3333, 1651,





7.26 (m, 2H), 7.20 (m,
815





1H), 6.60 (d, J = 15.9 Hz,






1H), 6.47 (dd, J = 15.9,






6.6 Hz, 1H),






4.86 (m, 1H), 4.65 (m, 2H),






4.13 (m, 3H), 2.84 (q,






2.8 Hz, 2H), 1.26 (m,






3H)



AC87

495.82 ([M − H]−)
8.07 (t, J = 8.0 Hz, 1H),
1623, 1114,





7.52 (m, 3H), 7.19 (d, J = 13.2 Hz,
816





1H), 6.59 (d,






J = 16.4 Hz, 1H),






6.47 (dd, J = 16.4, 8.0 Hz,






1H), 4.69 (m, 1H),






4.23 (m, 3H), 3.29 (m, 2H)



AC89

509.89 ([M + H]+)
7.43 (m, 2H), 7.27 (m,
1666, 1166,





2H), 7.23 (m, 2H),
1112, 800





6.58 (d, J = 16.0 Hz, 1H),






6.41 (dd, J = 16.0, 7.6 Hz,






1H), 4.79 (d, J = 5.6 Hz,






2H), 4.14 (m,






1H), 2.48 (s, 3H),






2.18 (m, 1H), 1.16 (m,






4H)



AC90

656.9 ([M − H]−)
8.34 (m, 1H), 8.27 (m,






1H), 7.60 (d, J = 1.6 Hz,






1H), 7.49 (d, J = 8.0 Hz,






2H), 7.40 (s, 2H),






7.36 (dd, J = 8.2, 1.7 Hz,






1H), 6.53 (d, J = 16.0 Hz,






1H), 6.38 (dd, J = 15.9,






7.9 Hz, 1H),






4.89 (d, J = 8.4 Hz, 2H),






4.48 (d, J = 9.0 Hz, 2H),






4.11 (m, 1H)



AC91

640.9 ([M − H]−)
8.18 (t, J = 5.0 Hz, 1H),






7.58 (d, J = 1.6 Hz, 1H),






7.47 (d, J = 8.0 Hz, 1H),






7.40 (s, 2H), 7.34 (dd, J = 8.1,






1.6 Hz, 1H),






6.52 (m, 2H), 6.37 (dd, J = 15.9,






7.9 Hz, 1H),






4.54 (d, J = 4.9 Hz, 2H),






4.12 (m, 1H), 3.99 (qd, J = 8.9,






6.5 Hz, 2H)



AC92

640.9 ([M − H]−)
9.16 (d, J = 6.1 Hz, 1H),






7.65 (d, J = 1.6 Hz, 1H),






7.57 (d, J = 8.0 Hz, 1H),






7.41 (m, 3H), 7.21 (t, J = 5.6 Hz,






1H), 6.55 (d, J = 15.9 Hz,






1H),






6.41 (dd, J = 15.9, 7.8 Hz,






1H), 4.59 (d, J = 5.6 Hz,






2H), 4.45 (qd, J = 9.0,






6.0 Hz, 2H), 4.12 (q, J = 7.2 Hz,






1H)



AC93

485.5 ([M + H]+)
7.52-7.41 (d, J = 8.2 Hz,
13C NMR (δ)3





1H), 7.39-7.34 (m, 1H),
169.91,





7.24-7.17 (d, J = 1.8 Hz,
169.84,





2H), 7.02-6.92 (m, 2H),
138.23,





6.90-6.83 (d, J = 11.4 Hz,
137.41,





1H), 6.71 (br s, 1H),
136.84,





6.17 (br s, 1H),
134.79,





6.12-6.01 (dd, J = 11.4, 10.3 Hz,
134.69,





1H), 4.44-4.38 (d, J = 4.2 Hz,
131.07,





1H),
128.69,





4.35-4.27 (m, 1H), 4.10-3.99 (d, J = 5.1 Hz,
127.49,





2H),
127.43,





2.78-2.67 (m, 1H), 2.44 (s, 3H),
126.72,





0.88-0.78 (m, 2H),
126.61 (q, J = 212.10 Hz),





0.60-0.45 (m, 2H)
125.61,






123.76,






47.89 (q, J = 28.28 Hz),






43.46,






22.65, 19.97,






8.21


AC94

511.6 ([M]−)
8.36-8.24 (d, J = 2.4 Hz,
3262, 1607,





1H), 7.75-7.64 (m,
1247, 1164,





1H), 7.38-7.24 (m,
1111





3H), 7.24-7.09 (d, J = 1.8 Hz,






2H),






6.99-6.90 (m, 2H), 6.89-6.74 (d,






J = 11.4 Hz, 1H),






6.63-6.43 (m, 1H),






6.14-5.98 (m, 1H),






4.69-4.51 (d, J = 6.1 Hz, 2H),






4.37-4.20 (m, 1H),






2.46-2.31 (s, 3H)



AC95
48-61
626.9 ([M + H]+)
7.58 (d, J = 7.9 Hz, 1H),






7.44-7.29 (m, 3H),






7.14 (dd, J = 7.9, 1.6 Hz,






1H), 6.86 (d, J = 11.4 Hz,






1H), 6.76 (t, J = 5.9 Hz,






1H), 6.59 (br






s, 1H), 6.21-6.04 (m,






1H), 4.23 (d, J = 5.5 Hz,






1H), 3.98 (qd, J = 9.0,






6.5 Hz, 2H)



AC96

619.6 ([M + H]+)
8.83 (s, 1H), 8.06 (br,
1616, 1114





1H), 7.90 (s, 2H),






7.63 (d, J = 8.1 Hz, 2H),






7.53 (m, 1H), 6.94 (m, 1H),






6.77 (d, J = 15.3 Hz,






1H), 6.63 (d, J = 9.3 Hz,






1H), 4.84 (m, 1H),






4.30 (d, J = 5.6 Hz, 2H),






2.99 (s, 6H)



AC97

606.6 ([M + H]+)
8.20 (d, J = 2.1 Hz,
1644, 1113





1H), 7.73 (d, J = 2.7 Hz,






1H), 7.60 (m, 2H),






7.39 (s, 2H), 7.29 (m, 1H),






6.79 (d, J = 8.4 Hz, 1H),






6.55 (d, J = 15.9 Hz,






1H), 6.40 (m, 2H),






4.60 (d, J = 2.7 Hz, 2H),






4.13 (m, 1H), 3.95 (s, 3H)



AC98

577.87 ([M + H]+)
9.04 (t, J = 6.0 Hz, 1H),
1663, 1168





8.60 (t, J = 6.6 Hz, 1H),






8.25 (s, 1H), 7.97 (d, J = 8.1 Hz,






1H), 7.87 (d, J = 6.3 Hz,






2H), 7.69 (d, J = 7.5 Hz,






1H), 7.15 (dd,






J = 15.9, 9.3 Hz, 1H),






6.89 (d, J = 15.9 Hz,






1H), 4.86 (m, 1H),






3.98 (m, 4H).



AC99

574.81 ([M + H]+)
8.69 (t, J = 6.0 Hz, 1H),
1650, 1164





8.58 (t, J = 6.6 Hz, 1H),






7.91 (s, 1H), 7.85 (m,






1H), 7.61 (m, 2H),






7.52 (m, 2H), 6.98 (dd, J = 15.3,






9.0 Hz, 1H),






6.76 (d, J = 15.3 Hz, 1H),






4.81 (m, 1H), 4.01 (m,






4H)



AC100

673.80 ([M + H]+)
8.29 (s, 1H), 8.22 (d, J = 8.1 Hz,
3403, 1659





1H), 7.93 (d, J = 7.8 Hz,






1H), 7.72 (m,






1H), 7.65 (m, 2H),






7.40 (s, 2H), 7.18 (br, 1H),






6.59 (d, J = 16.0 Hz,






1H), 6.43 (dd, J = 16.0,






7.6 Hz, 1H), 5.02 (d, J = 1.2 Hz,






2H), 4.12 (m,






1H)



AC101

636.83 ([M + H]+)
7.56 (d, J = 9.0 Hz,
1637, 1113





1H), 7.39 (d, J = 6.0 Hz,






2H), 7.26 (m, 2H),






6.54 (d, J = 15.9 Hz,






1H), 6.37 (dd, J = 8.0,






15.9 Hz, 1H), 4.01 (m,






1H), 3.84 (m, 2H),






3.33 (m, 2H), 3.04 (m, 2H),






2.84 (m, 3H), 2.62 (m,






1H)



AC102

592.84 ([M + H]+)
7.60 (m, 2H), 7.32 (m,
1668, 1167





1H), 7.03 (d, J = 7.2 Hz,






2H), 6.74 (br, 1H),






6.62 (br, 1H), 6.56 (d, J = 16.2 Hz,






1H), 6.41 (dd,






J = 16.2, 7.8 Hz, 1H),






4.22 (d, J = 5.4 Hz,






2H), 4.14 (m, 1H),






4.01 (m, 2H)



AC103
 99.2-105.0
612.7 ([M + H]+)
8.40 (d, J = 8.0 Hz, 1H),
1634, 1113,





7.92 (d, J = 5.2 Hz, 1H),
809





7.59 (d, J = 8.0 Hz, 1H),






7.35 (d, J = 8.0 Hz, 1H),






6.99 (dd, J = 16.0, 7.6 Hz,






1H), 6.76 (d, J = 16.0 Hz,






1H), 4.84 (m,






1H), 4.23 (d, J = 13.2 Hz,






1H), 3.97 (m, 1H),






3.79 (d, J = 13.6 Hz,






1H), 3.16 (t, J = 11.2 Hz,






1H), 2.77 (t, J = 11.2 Hz,






1H), 1.99 (s,






3H), 1.88 (m, 2H),






1.45 (m, 2H)



AC104

680.97 ([M + H]+)
7.60 (m, 2H), 7.40 (m
3437,





3H), 6.55 (d, J = 15.6 Hz,
1644,





1H), 6.41 (dd, J = 15.6,
1113,





7.8 Hz, 1H),
807,





4.24 (m, 1H), 3.34 (m, 2H),
511





2.90 (m, 1H), 2.24 (m,






2H), 1.52 (m, 2H),






1.34 (m, 4H)



AC105

609.9 ([M + H]+)
7.59 (s, 1H), 7.55 (m,
3303, 1649,





1H), 7.50 (m, 1H),
1115, 2242,





7.40 (m, 2H), 6.54 (d, J = 16.0 Hz,
809, 506





1H), 6.50 (J = 16.0,






8.0 Hz, 1H),






4.14 (m, 2H), 3.08 (m, 4H),






2.67 (m, 2H), 2.12 (m,






2H), 1.70 (m, 2H).



AC106

584.95 ([M + H]+)
7.59 (s, 1H), 7.51 (d, J = 8.4 Hz,
3417,





1H), 7.40 (s,
1648,





2H), 7.36 (d, J = 6.8 Hz,
1112,





1H), 6.54 (d, J = 16.0 Hz,
805, 555





1H), 6.40 (dd, J = 16.0,






8.0 Hz, 1H),






6.03 (d, J = 8.0 Hz, 1H),






4.11 (m, 2H), 3.10 (m, 2H),






2.50 (m, 2H), 2.50 (s,






3H) (m, 2H), 1.94 (m,






2H)



AC107

609.9 ([M + H]+)
8.41 (d, J = 7.8 Hz, 1H),
3303,





7.90 (s, 2H), 7.62 (m,
1645,





2H), 7.51 (m, 1H),
1115,





6.92 (dd, J = 15.9, 9.0 Hz,
2243,





1H), 6.77 (d, J = 15.9 Hz,
810,





1H), 4.81 (m, 1H),
507





3.73 (s, 2H), 3.31 (m,






1H), 3.28 (m, 1H),






2.82 (t, J = 11.4 Hz, 2H),






2.82 (m, 2H), 2.30 (m,






2H), 1.88 (m, 2H),






1.57 (m, 2H)



AC108

626.9 ([M + H]+)
7.60 (m, 2H) 7.39 (s,
3420,





2H), 7.28 (m, 1H),
1649,





6.56 (d, J = 15.6 Hz, 1H),
1113,





6.40 (dd, J = 15.6, 7.8 Hz,
809,





1H), 5.91 (m, 1H),
554





4.65 (m, 2H), 4.10 (m,






1H), 4.07 (m, 2H),






3.59 (m, 1H), 2.74 (m, 2H),






2.13 (m, 4H), 2.07 (m,






1H)



AC109

614.6 ([M + H]+)
7.56 (m, 2H), 7.39 (s,
1647, 1113





2H), 7.29 (s, 1H),






6.50 (d, J = 15.9 Hz, 1H),






6.41 (dd, J = 15.9, 8.0 Hz






1H), 4.09 (m, 1H),






3.88 (m, 2H), 3.49 (m,






2H), 2.92 (m, 2H),






2.81 (m, 1H), 2.74 (m, 2H),






2.25 (m, 4H)



AC110

572.6 ([M + H]+)
11.20 (s, 1H), 8.66 (br,
3412, 1690,





1H), 7.92 (m, 3H),
1114, 846,





7.62 (d, J = 8.0 Hz, 1H),
559





7.45 (d, J = 8.0 Hz, 1H),






6.77 (dd, J = 15.6, 9.2 Hz,






1H), 6.77 (d, J = 15.6 Hz,






1H), 4.85 (m, 1H),






3.74 (d, J = 5.2 Hz, 2H),






3.61 (s, 3H)



AC111

582.79 ([M + H]+)
8.63 (t, J = 6.0 Hz, 1H),
3419, 1659,





8.04 (t, J = 6.0 Hz, 1H),
843, 557





7.92 (m, 3H), 7.62 (d, J = 1.2 Hz,






1H), 7.47 (d, J = 7.6 Hz,






1H), 7.00 (dd,






J = 15.6, 8.8 Hz, 1H),






6.77 (d, J = 15.6 Hz,






1H), 5.19 (d, J = 1.6 Hz,






1H), 5.01 (d, J = 1.2 Hz,






1H), 4.85 (m, 1H),






3.86 (d, J = 5.6 Hz, 2H),






3.75 (t, J = 5.6 Hz, 2H)



AC112

582.79 ([M + H]+)
8.84 (br, 1H), 8.58 (m,
3399, 1662,





1H), 8.30 (m, 1H),
1114, 807,





7.91 (s, 2H), 7.61 (d, J = 8.1 Hz,
582





1H), 7.42 (d, J = 7.8 Hz,






1H), 7.00 (dd, J = 15.6,






9.3 Hz, 1H),






6.77 (d, J = 15.6 Hz, 1H),






4.85 (m, 1H), 4.11 (d, J = 5.6 Hz,






1H), 3.73 (d,






J = 5.6 Hz, 1H), 3.04 (s,






6H)



AC113

626.88 ([M + H]+)
8.48 (t, J = 5.2 Hz, 1H),
3431, 1651,





8.3 (s, 1H), 7.90 (s, 2H),
1113, 808,





7.79 (dd, J = 2.0, 2.0 Hz
554





2H), 7.58 (d, J = 8.4 Hz,






1H) 7.46 (d, J = 7.6 Hz,






1H) 7.26 (d, J = 7.6 Hz,






1H), 6.98 (m, 1H),






6.75 (d, J = 15.6 Hz, 1H),






4.85 (m, 1H), 3.49 (d, J = 6.4 Hz,






2H) 2.87 (t, J = 6.4 Hz,






2H)



AC114
113.7-117.5
570.7 ([M + H]+)
8.77 (s, 1H), 8.58 (d, J = 7.2 Hz,






2H), 7.93 (d, J = 7.2 Hz,






2H), 7.60 (dd, J = 1.2,






0.8 Hz, 1H),






7.37 (d, J = 7.6 Hz, 1H),






6.99 (m, 1H), 6.77 (d, J = 16 Hz,






1H), 4.85 (m, 1H),






4.10 (m, 1H) 3.29 (m,






2H), 3.05 (m, 2H),






2.0 (m, 2H), 1.76 (m, 2H)



AC115

529.00 ([M + H]+)
8.43 (s, 1H), 7.79 (d, J = 8.0 Hz,
1589, 3459,





1H), 7.51 (m,
801, 1110





1H), 7.36 (d, J = 8.4 Hz,






3H), 7.21 (m, 3H),






6.55 (d, J = 15.6 Hz, 1H),






6.36 (dd, J = 15.6, 8.0 Hz,






1H), 5.04 (d, J = 5.6 Hz,






2H), 4.10 (m, 1H),






2.35 (s, 3H)



AC116

614.87 ([M + H]+)
7.99 (d, J = 8.4 Hz, 1H),
3424, 1657,





7.46 (d, J = 1.6 Hz, 1H),
1165





7.34 (d, J = 6.4 Hz, 2H),






7.28 (m, 2H), 6.62 (m,






2H), 6.47 (dd, J = 16.0,






7.2 Hz, 1H), 4.23 (m,






2H), 4.12 (m, 1H),






4.00 (m, 2H)



AC117

525.42 ([M − H]−)
8.39 (br, 1H), 7.85 (br,
3401, 1636,





1H), 7.62 (m, 3H),
1113, 750





7.53 (d, J = 8.0 Hz, 1H),






7.46 (s, 1H), 7.40 (d, J = 8.0 Hz,






1H), 7.17 (m, 1H),






6.78 (dd, J = 16.0, 8.8 Hz,






1H), 6.70 (m, 1H),






4.77 (m, 1H), 4.66 (s,






1H), 4.32 (s, 1H),






2.97 (s, 3H), 2.16 (s, 3H)



AC118

471.79 ([M + H]+)
7.36 (d, J = 8.0 Hz, 2H),
3437, 1655,





7.27 (m, 2H), 7.22 (m,
1262, 1105,





2H), 6.57 (d, J = 16.0 Hz,
802





1H), 6.38 (dd, J = 16.0,






8.0 Hz, 1H),






6.10 (br, 1H), 4.15 (m, 2H),






3.89 (m, 1H), 3.80 (m,






2H), 3.35 (m, 1H),






2.46 (s, 3H), 2.06 (s, 1H),






1.96 (m, 2H), 1.65 (m,






1H)



BC1

492.17 ([M + H]+)
7.39 (s, 2H),
3211, 1569,





7.25-7.18 (m, 3H), 6.58 (d, J = 16.0 Hz,
1113, 806





1H), 6.30 (dd,






J = 16.0, 8.4 Hz, 1H),






5.91-5.70 (br, 2H),






4.05 (m, 1H),






3.05-2.80 (m, 6H), 2.70 (m,






1H), 1.81 (m, 1H)



BC2

506.4 ([M + H]+)
8.80 (s, 1H), 8.20 (s,
2923, 1542,





1H), 7.82 (m, 3H),
1033, 805





7.4 (s, 2H), 6.62 (d, J = 16.0 Hz,






1H), 6.52 (dd, J = 16.0,






8.0 Hz, 1H),






4.18 (m, 1H), 3.38 (m,






2H), 2.98 (m, 2H),






2.71 (m, 1H), 2.04 (m, 2H),






1.54 (s, 3H).



BC3

518.04 ([M − H]−)
7.40 (s, 2H),
3120, 1592,





7.33-7.22 (m, 3H), 6.61 (d, J = 16.0 Hz,
1146, 895





1H),






6.34-6.28 (dd, J = 16.0, 8.0 Hz,






1H), 5.96-5.80 (m,






3H), 5.22 (m, 4H),






4.01 (m, 2H), 2.84-2.99 (m,






2H), 2.71 (m, 1H),






1.86 (m, 1H)



BC4

529.02 ([M + H]+)
7.39 (s, 2H),
3283, 1652,





7.25-7.20 (m, 3H), 6.34 (d, J = 16.0 Hz,
1241, 811





1H), 6.30 (dd,






J = 16.0, 8.0 Hz, 1H),






5.81 (br, 1H), 5.48 (m,






1H), 4.10 (m, 1H),






3.10 (m, 2H), 2.86-3.07 (m,






2H), 2.86 (m, 1H),






1.81 (m, 1H);



BC5

544.25 ([M − H]−)
7.40 (s, 2H), 7.21 (s,
3489, 3291,





1H), 7.12 (m, 1H),
1655, 1112,





6.56 (d, J = 16.0 Hz, 1H),
808





6.32 (dd, J = 16.0, 8.4 Hz,






1H), 5.85 (br s, 1H),






5.23 (br s, 1H), 4.12 (m,






1H), 3.18 (m, 3H),






2.80 (m, 3H), 2.08 (m, 2H),






1.83 (m, 5H), 1.25 (m,






2H), 1.01 (m, 3H),






0.78 (m, 2H)



BC6

485.96 ([M − H]−)
7.40 (s, 2H),
3429, 1114,





7.31-7.18 (m, 3H), 6.58 (d, J = 16.0 Hz,
804





1H),






6.24-6.28 (dd, J = 16.0, 8.0 Hz,






1H), 5.40 (br, 1H),






4.01 (m, 2H),






2.78-3.01 (m, 2H), 2.51 (s,






1H), 1.86 (m, 1H),






1.20 (m, 2H), 1.01 (m, 2H),






0.78 (m, 2H)



BC7

500.01 ([M − H]−)
7.40 (s, 2H), 7.31 (s,
3296, 1115,





1H), 7.18 (m, 1H),
806





7.18 (s, 1H), 6.58 (d, J = 16.0 Hz,






1H), 6.32 (dd, J = 16.0,






8.0 Hz, 1H),






5.78 (br s, 1H), 5.21 (br s,






1H), 4.01 (m, 1H),






2.78 (m, 2H), 2.01 (m, 1H),






1.86 (m, 4H), 1.25 (m,






2H), 1.01 (m, 3H),






0.78 (m, 2H)



BC8

511.88 ([M − H]−)
7.38-7.20 (m, 5H),
1657, 1113,





6.62 (d, J = 16.0 Hz, 1H),
855





6.34 (dd, J = 16.0, 8.0 Hz,






1H), 5.83 (br, 1H),






5.52 (m, 1H), 4.12 (m,






1H), 3.12 (m, 2H),






3.06-2.82 (m, 2H), 2.75 (m,






1H), 1.85 (m, 1H)



BC9
179-181
556.83 ([M − H]−)
8.30 (s, 1H), 7.68 (d, J = 6.4 Hz,






1H),






7.38-7.20 (m, 5H), 6.60 (d, J = 16.0 Hz,






1H), 6.34 (dd,






J = 16.0, 8.0 Hz, 1H),






5.63 (br, 1H), 5.52 (m,






1H), 4.12 (m, 1H),






3.56 (s, 2H), 3.06-2.82 (m,






2H), 2.70 (m, 1H),






1.82 (m, 1H)



BC10

497.98 ([M − H]−)
7.38-7.20 (m, 5H),
3027, 1654,





6.62 (d, J = 16.0 Hz, 1H),
815





6.34 (dd, J = 16.0, 8.0 Hz,






1H), 5.83 (br, 1H),






5.52 (m, 1H), 4.12 (m,






1H), 3.02 (m, 3H),






2.82 (m, 1H), 2.50 (m, 3H),






1.82 (m, 1H), 1.42 (m,






1H)



BC11

530.09 ([M − H]−)
7.80 (m, 1H), 7.48 (m,
1715, 1113,





2H), 7.32 6.65 (d, J = 16.0 Hz,
816





1H), 6.54 (dd,






J = 16.0, 8.0 Hz, 1H),






5.38 (m, 1H), 4.18 (m,






1H), 3.62 (m, 1H),






3.32 (m, 1H), 2.86 (m, 1H),






1.81 (m, 1H)



BC12

514.86 ([M + H]+)
7.32, (d, J = 6.0 Hz, 2H)
3428, 1112,





7.28 (m, 1H), 7.20 (d, J = 8.0,
857





1H), 7.14 (d, J = 8.8,






1H), 6.70 (d, J = 8.0 Hz,






1H), 6.60 (m,






2H), 4.15 (m, 1H),






3.85 (m, 1H), 3.65 (m, 1H),






3.46 (m, 2H), 3.19 (m,






2H);



BC13
121-126
553.06 ([M − H]−)
8.33 (br, 1H), 7.59 (s,






1H), 7.45 (m, 3H),






6.72 (d, J = 3.6, 1H),






6.39 (m, 1H), 4.71 (t, J = 7.2 Hz,






2H), 4.15 (m, 2H)



BC14
172-175
554.0 ([M − H]−)
8.83 (t, J = 6.6 Hz, 1H),






8.42 (t, J = 14.7 Hz,






1H), 8.22 (d, J = 8.1 Hz,






1H), 8.13 (t, J = 6.3 Hz,






1H), 7.98-7.86 (m,






2H), 7.16-7.07 (m,






1H), 7.01-6.93 (m,






1H), 4.96-4.81 (m,






3H), 4.00-3.88 (m, 2H)



CC1
107-109
402.00 ([M + H]+)
7.37 (m, 3H), 7.28 (m,






4H), 6.60 (d, J = 16.0 Hz,






1H), 6.36 (dd, J = 16.0,






8.0 Hz, 1H),






5.75 (br s, 1H), 4.46 (d, J = 6 Hz,






2H), 4.01 (m, 1H),






2.11 (s, 3H)



CC2
118-120
428.11 ([M + H]+)
7.37 (m, 3H), 7.28 (m,






4H), 6.60 (d, J = 16.0 Hz,






1H), 6.35 (dd, J = 16.0,






8.0 Hz, 1H),






5.83 (br s, 1H), 4.46 (d, J = 6.0 Hz,






2H), 4.11 (m,






1H), 1.40 (m, 1H),






1.02 (m, 2H), 0.77 (m, 2H)



CC3
119-122
468.20 ([M − H]−)
7.38 (m, 3H), 7.27 (m,






3H), 6.60 (d, J = 16.0 Hz,






1H), 6.36 (dd, J = 16.0,






8.4 Hz, 1H),






5.00 (br s, 1H), 4.48 (d, J = 5.6 Hz,






2H), 4.11 (m,






1H), 3.15 (q, J = 10.4 Hz,






2H)



CC4

414.16 ([M − H]−)
7.37 (m, 3H), 7.28 (m,






3H), 6.60 (d, J = 16.0 Hz,






1H), 6.35 (dd, J = 16.0,






8.0 Hz, 1H),






5.69 (br s, 1H), 4.46 (d, J = 6.0 Hz,






2H), 4.21 (m,






1H), 2.29 (q, J = 5.8 Hz,






2H), 1.30 (t, J = 7.2 Hz,






3H)



CC5

460.28 ([M − H]−)
7.40 (m, 3H), 7.28 (m,






2H), 6.60 (d, J = 15.6 Hz,






1H), 6.33 (dd, J = 15.6,






8.0 Hz, 1H),






5.84 (br s, 1H), 4.46 (d, J = 5.6 Hz,






2H), 4.10 (m,






1H), 1.36 (m, 1H),






1.02 (m, 2H), 0.77 (m, 2H)



CC6
106-108
504.08 ([M − H]−)
7.40 (m, 3H), 7.26 (m,






1H), 6.60 (d, J = 16.0 Hz,






1H), 6.34 (dd, J = 16.0,






8.0 Hz, 1H),






5.96 (br s, 1H), 4.49 (d, J = 5.6 Hz,






2H), 4.10 (m,






1H), 3.15 (q, J = 10.8 Hz,






2H)



CC7
127-128
436.03 ([M + H]+)
7.42 (m, 4H), 7.24 (m,






2H), 6.53 (d, J = 16.0 Hz,






1H), 6.36 (dd, J = 16.0,






8.0 Hz, 1H),






5.86 (br s, 1H), 4.51 (d, J = 6.0 Hz,






2H), 4.05 (m,






1H), 2.02 (s, 3H)



CC8
129-131
462.15 ([M + H]+)
8.58 (t, J = 5.6 Hz, 1H),






7.72 (m, 1H), 7.66 (m,






3H), 7.49 (d, J = 8.0 Hz,






1H), 7.30 (d, J = 8.0 Hz,






1H), 6.90 (dd, J = 16.0,






8.0 Hz, 1H), 6.73 (d, J = 16 Hz,






1H), 4.81 (m,






1H), 4.33 (d, J = 6.0 Hz,






1H), 1.64 (m, 1H),






0.68 (m, 4H)



CC9
132-134
504.25 ([M + H]+)
7.41 (m, 3H), 7.26 (m,






3H), 6.54 (d, J = 16.0 Hz,






1H), 6.37 (dd, J = 16.0,






8.0 Hz, 1H),






6.13 (br s, 1H), 4.56 (d, J = 6.0 Hz,






2H), 4.11 (m,






1H), 3.13 (m, 2H)



CC10

538.03 ([M + 2H]+)
7.38 (m, 4H), 6.56 (d, J = 16.0 Hz,
1651, 1112,





1H),
807





6.38 (dd, J = 16.0, 8.0 Hz,






1H), 6.18 (m, 1H),






4.58 (m, 2H), 4.08 (m, 1H),






3.08 (m, 2H)



CC11
111-112
494.12 ([M − H]−)
7.42 (m, 3H), 7.24 (m,






1H), 6.54 (d, J = 15.6 Hz,






1H), 6.34 (dd, J = 16.0,






8.0 Hz, 1H),






6.03 (m, 1H), 4.53 (d, J = 6.0 Hz,






1H), 4.10 (m, 1H),






1.39 (m, 1H), 1.00 (m,






2H), 0.77 (m, 2H)



CC12
76-78
510.07 ([M − H]−)
7.39 (s, 4H), 7.34 (d, J = 8.0 Hz,






1H), 7.26 (m,






1H), 6.57 (d, J = 16.0 Hz,






1H), 6.35 (dd, J = 16.0,






8.0 Hz, 1H),






6.10 (br s, 1H), 4.49 (d, J = 6.0 Hz,






2H), 4.10 (m,






1H), 1.20 (s, 9H)



CC13
73-76
563.37 ([M − H]−)
8.51 (d, J = 5.2 Hz, 1H),






7.63 (s, 1H), 7.51 (m,






1H), 7.45 (m, 2H),






7.39 (s, 2H), 7.28 (m, 1H),






6.58 (m, 2H), 6.37 (dd, J = 16.0,






8.0 Hz, 1H),






4.71 (d, J = 6.0 Hz, 1H),






4.11 (m, 1H)



CC14

581.45 ([M + 1H]+)
8.51 (m, 1H), 8.30 (d, J = 2.4 Hz,
3430, 1656,





1H), 7.73 (m,
1109, 806





1H), 7.61 (s, 2H),






7.51 (s, 1H), 7.32 (m, 3H),






6.66 (d, J = 16.0 Hz,






1H), 6.56 (dd, J = 16.0,






8.4 Hz, 1H), 4.50 (m,






1H), 4.45 (d, J = 5.6 Hz,






1H), 3.56 (s, 2H)



CC15

480.24 ([M + H]+)
7.40 (m, 3H), 7.33 (m,
3293, 1651,





1H), 7.22 (m, 2H),
1543, 1114,





6.54 (d, J = 15.6 Hz, 1H),
812





6.34 (dd, J = 16.0, 8.0 Hz,






1H), 6.03 (br s, 1H),






4.53 (d, J = 6.0 Hz, 2H),






4.13 (m, 1H), 1.41 (m,






1H), 1.00 (m, 2H),






0.77 (m, 2H)



CC16

520.33 ([M − H]−)
7.42 (s, 1H), 7.37 (m,
3307, 1665,





3H), 7.22 (m, 1H),
1114, 813





6.54 (d, J = 16.0 Hz, 1H),






6.36 (dd, J = 16.0, 8.0 Hz,






1H), 6.19 (br s, 1H),






4.51 (d, J = 6.0 Hz, 2H),






4.21 (m, 1H), 3.33 (m,






2H)



CC17
117-119
459.83 ([M − H]−)
7.51 (m, 2H), 7.39 (m,
3293, 1633,





2H), 7.24 (m, 2H),
1110, 820





6.52 (d, J = 15.6 Hz, 1H),






6.38 (dd, J = 15.6, 7.6 Hz,






1H), 6.02 (br s, 1H),






4.53 (d, J = 6.0 Hz, 2H),






4.14 (m, 1H), 1.38 (m,






1H)), 1.00 (m, 2H),






0.77 (m, 2H)



CC18
119-123
501.88 ([M − H]−)
7.48 (m, 2H), 7.41 (s,
3435, 1644,





1H), 7.36 (d, J = 8.0 Hz,
1111, 817





1H), 7.23 (m, 2H),






6.52 (d, J = 16.0 Hz, 1H),






6.39 (dd, J = 16.0, 8.0 Hz,






1H), 6.13 (br s, 1H),






4.56 (d, J = 6.0 Hz, 2H),






4.15 (m, 1H), 3.13 (m,






2H)



CC19

530 ([M + H]+)
7.41 (m, 2H), 7.24 (m,
3435, 1644,





1H), 6.53 (d, J = 16.0 Hz,
1111, 817





1H), 6.35 (dd, J = 16.0,






8.0 Hz, 1H),






4.53 (m, 2H), 4.10 (m, 1H),






3.42 (m, 2H), 2.97 (s,






3H), 2.78 (m, 2H)



CC20

512 ([M + H]+)
7.42 (m, 3H), 7.24 (m,
3293, 1633,





1H), 6.54 (d, J = 15.6 Hz,
1110, 820





1H), 6.34 (dd, J = 15.6,






8.0 Hz, 1H),






6.03 (m 1H), 4.53 (d, J = 6.0 Hz,






1H), 4.10 (m, 1H),






1.19 (m, 1H), 1.00 (m,






2H), 0.77 (m, 2H)



CC21
55-58
493.99 ([M − H]−)
(DMSO-d6) 8.62 (m,






1H), 7.95 (s, 1H),






7.85 (m, 1H), 7.66 (m, 3H),






7.47 (d, J = 8.0 Hz, 1H),






6.98 (dd, J = 16.0, 8.0 Hz,






1H), 6.84 (d, J = 16.0 Hz,






1H), 4.83 (m,






1H), 4.44 (s, 2H),






1.68 (m, 1H), 0.71 (m, 4H)



CC22
67-69
530.01 ([M + H]+)
8.62 (m, 1H), 7.90 (s,






3H), 7.82 (m, 1H),






7.45 (m, 1H), 6.98 (m, 1H),






6.84 (d, J = 16.0 Hz,






1H), 4.82 (m, 1H),






4.4 (s, 2H), 1.66 (m, 1H),






0.72 (m, 4H)



CC23
69-71
564.99 ([M − H]−)
9.02 (br s, 1H), 8.54 (br






s, 1H), 8.26 (br s, 1H),






7.48-7.54 (m, 3H),






7.22-7.42 (m, 3H),






6.59-6.62 (m, 2H),






6.38-6.42 (m, 1H),






4.82 (m, 2H), 4.19 (s,






1H)



CC24
125-127
570.26 ([M − H]−)
7.64 (s, 1H), 7.54 (s,






2H), 7.46 (s, 2H),






6.62 (d, J = 16.0 Hz, 1H),






6.41 (dd, J = 16.0, 8.4 Hz,






1H), 6.03 (m, 1H),






4.65 (d, J = 6.4 Hz, 2H),






4.14 (m, 1H,), 3.13 (q, J = 10.6 Hz,






2H)



CC25

579.86 ([M − H]−)
7.60 (s, 1H), 7.40 (s,
3297, 1663,





2H), 7.37 (d, J = 8.0 Hz,
1114, 809





1H), 7.31 (d, J = 8.0 Hz,






1H), 6.53 (d, 1H, J = 16.0 Hz),






6.35 (dd, J = 16.0,






8.0 Hz, 1H),






6.17 (br s, 1H), 4.56 (d, J = 6.4 Hz,






2H), 4.12 (m,






1H), 3.15 (q, J = 10.6 Hz,






2H)



CC26
129-131
539.89 ([M + H]+)
7.59 (s, 1H), 7.39 (m,






2H), 7.30 (s, 1H),






6.53 (d, J = 16.0 Hz, 1H),






6.35 (dd, J = 16.0, 8.0 Hz,






1H), 6.06 (br s, 1H),






4.42 (d, J = 4.4 Hz, 2H),






4.12 (m, 1H), 1.35 (br s,






1H), 0.95 (br s, 2H),






0.75 (m, 2H)



CC27

519.95 ([M − H]−)
7.39 (s, 2H), 7.33 (t, J = 7.6 Hz,
3306, 1786





1H), 7.14 (m,






2H), 6.56 (d, J = 16.0 Hz,






1H), 6.35 (dd, J = 16.0,






7.6 Hz, 1H),






6.06 (br s, 1H), 4.52 (d, J = 16.0 Hz,






2H), 4.08 (m,






1H), 3.90 (s, 2H),






3.13 (m, 2H)



CC28

477.93 ([M − H]−)
7.39 (s, 2H), 7.35 (m,
3625, 1747





1H), 7.14 (m, 2H),






6.55 (d, J = 15.6 Hz, 1H),






6.33 (dd, J = 15.6, 8.0 Hz,






1H), 5.93 (br s, 1H),






4.49 (d, J = 16.0 Hz,






2H), 4.10 (m, 1H),






1.36 (m, 1H), 1.00 (m, 2H),






0.77 (m, 2H)



CC29

620.86 ([M − H]−)
8.58 (d, J = 4.6 Hz, 1H),
1645, 1115,





7.74 (m, 1H), 7.62 (m,
808





2H), 7.52 (m, 1H),






7.4 (s, 2H), 7.3 (m, 1H),






7.2 (m, 2H), 6.60 (d, J = 16.0 Hz,






1H), 6.38 (dd,






J = 16.0, 8.0 Hz, 1H),






5.02 (s, 1H), 4.8 (s, 1H),






4.8 (d, J = 10 Hz, 2H),






4.10 (m, 1H), 1.8 (m,






1H), 1.2 (m, 2H),






0.6 (m, 2H)



CC30
101-104
559.75 ([M − H]−)
7.41 (m, 4H), 7.24 (m,






1H), 6.53 (d, J = 16.0 Hz,






1H), 6.35 (dd, J = 16.0,






8.0 Hz, 1H),






6.12 (br s, 1H), 4.53 (m, 2H),






4.10 (m, 1H), 3.42 (m,






2H), 2.91 (s, 3H),






2.78 (m, 2H)



CC31
177-178
463 ([M − H]−)
7.58 (m, 2H), 7.41 (m,






3H), 7.24 (m, 1H),






6.53 (d, J = 16.0 Hz, 1H),






6.35 (dd, J = 16.0, 8.0 Hz,






1H), 4.70 (br s, 1H),






4.43 (s, 2H), 4.08 (m,






1H), 3.21 (m, 2H),






1.25 (m, 3H);



CC32
141-142
532.99 ([M + H]+)
7.66 (m, 2H), 7.54 (m,






1H), 7.41 (s, 2H),






6.62 (d, J = 16.0 Hz, 1H),






6.40 (dd, J = 16.0, 8.0 Hz,






1H), 4.59 (s, 3H),






4.19 (m, 1H), 3.25 (m,






2H), 1.15 (m, 2H)



CC33

540.88 ([M − H]−)
7.57 (s, 1H), 7.40 (m,
3338, 1631,





2H), 7.30 (s, 1H),
1578, 1114,





7.20 (br s, 1H), 6.53 (d, J = 16.0 Hz,
809





1H), 6.33 (dd,






J = 16.0, 8.0 Hz, 1H),






6.06 (br s, 1H), 4.75 (br






s, 1H), 4.42 (s, 2H),






4.20 (br s, 1H), 4.15 (m, 2H),






3.20 (m, 2H), 1.15 (m,






3H)



CC34
118-120
541.40 ([M + H]+)
7.42 (m, 3H), 7.28 (m,






2H), 6.54 (d, J = 16.0 Hz,






1H), 6.36 (dd, J = 16.0,






8.0 Hz, 1H),






4.96 (m, 1H), 4.51 (d, J = 5.6 Hz,






2H), 4.12 (m, 1H),






3.69 (t, J = 4.8 Hz, 4H),






3.35 (t, J = 4.8 Hz, 1H)



CC35
78-79
547.82 ([M + H]+)
9.95 (br s, 1H), 8.17 (d,






J = 4.8 Hz, 1H), 7.61 (d,






J = 6.4 Hz), 7.43 (m,






3H), 7.24 (m, 2H),






6.90 (t, J = 5.6 Hz, 1H),






6.66 (d, J = 8.4 Hz, 1H),






6.54 (d, J = 16.0 Hz, 1H),






6.33 (dd, J = 16.0, 8.0 Hz,






1H), 4.65 (d, J = 6.0 Hz,






1H), 4.09 (m, 1H)



CC36

497 ([M − H]−)
7.39 (m, 4H), 7.28 (m,
3350, 1705,





1H), 6.54 (d, J = 16.0 Hz,
1114, 808





1H), 6.34 (dd, J = 16.0,






8.0 Hz, 1H),






4.97 (br s, 1H), 4.38 (d, J = 6.0 Hz,






2H), 4.10 (m,






1H), 2.9 (s, 3H), 2.7 (s,






3H)



CC37
88-91
515.01 ([M + H]+)
7.49 (d, J = 8 Hz, 1H),






7.41 (d, J = 7.2 Hz, 2H),






7.26 (m, 2H), 6.50 (d, J = 16 Hz,






1H), 6.35 (dd,






J = 16.0, 8.0 Hz, 1H),






6.0 (brs, 1H), 5.73 (br s,






1H), 4.80 (br s, 2H),






4.09 (m, 1H), 1.23 (m,






3H)



CC38
63-66
526.97 ([M + H]+)
7.48 (d, J = 8 Hz, 1H),






7.39 (m, 3H), 7.27 (m,






1H), 6.54 (d, J = 16 Hz,






1H), 6.33 (dd, J = 6.0,






8.0 Hz, 1H), 6.17 (br s,






1H), 5.92 (br s, 1H),






5.83 (m, 2H), 5.29 (t, J = 15.4 Hz,






2H), 4.80 (br






s, 2H), 4.12 (m, 1H),






4.02 (br s, 2H)



CC39

526.09 ([M − H]−)
7.39 (m, 4H), 7.28 (m,
3350, 1705,





1H), 6.54 (d, J = 16.0 Hz,
1114, 808





1H), 6.34 (dd, J = 16.0,






8.0 Hz, 1H),






4.97 (br s, 1H), 4.38 (d, J = 6.0 Hz,






2H), 4.10 (m,






1H), 1.53 (s, 9H)



CC40
159-160
580.25 ([M − H]−)
7.46 (m, 5H), 7.29 (m,






1H), 7.20 (m, 3H),






6.55 (d, J = 16.0 Hz, 1H),






6.37 (dd, J = 16.0, 8.0 Hz,






1H), 5.62 (br s, 1H),






4.55 (d, J = 6.4 Hz, 2H),






4.11 (m, 1H)



CC41

512.22 ([M − H]−)
7.48 (m, 1H), 7.43 (m,
1740, 1701,





3H), 7.38 (m, 1H),
1114, 808





7.23 (s, 1H), 6.55 (d, J = 16.0 Hz,






1H), 6.36 (d, J = 16.0 Hz,






1H), 4.60 (d,






2H), 4.18 (m, 1H),






3.85 (s, 3H)



CC42
161-163
578.96 ([M − H]−)
(DMSO-d6) 9.45 (br s,






2H), 7.90 (s, 2H),






7.75 (s, 1H), 7.46 (br s, 1H),






7.28 (br s, 1H), 6.93 (m,






1H), 6.75 (br s, 1H),






4.80 (m, 1H), 4.40 (br s,






2H), 3.90 (br s, 2H)



CC43
140-142
505.39 ([M + H]+)
8.11 (d, J = 4.0 Hz, 1H),






7.40 (m, 5H), 7.22 (m,






1H), 6.61 (m, 2H),






6.35 (m, 2H), 4.94 (br s, 1H)






4.61 (d, J = 6.4 Hz, 2H),






4.11 (m, 1H)



CC44

536.88 ([M − H]−)
8.41 (s, 1H), 7.77 (s,
3320, 1674,





1H), 7.47 (br s, 1H),
1114, 808





7.40 (s, 2H), 6.58 (d, J = 16.0 Hz,






1H), 6.45 (dd,






J = 16.0, 8.0 Hz, 1H),






4.68 (d, J = 4.0 Hz, 2H),






4.14 (m, 1H), 3.24 (q, J = 10.8 Hz,






2H)



CC45

494.88 ([M − H]−)
8.41 (s, 1H), 7.76 (s,
3309, 1659,





1H), 7.40 (s, 2H),
1115, 808





7.15 (br s, 1H), 6.58 (d, J = 16.0 Hz,






1H), 6.44 (dd,






J = 16.0, 8.0 Hz, 1H),






4.67 (d, J = 4.4 Hz, 2H),






4.16 (m, 1H), 1.57 (m,






1H), 1.04 (m, 2H),






0.87 (m, 2H)



CC46
151-153
554.04 ([M − H]−)
8.06 (m, 1H), 7.61 (m,






4H), 7.48 (s, 2H),






7.44 (d, J = 8.0 Hz, 1H),






7.38 (m, 1H), 6.42 (m, 1H),






5.92 (br s, 1H), 4.92 (m,






2H), 4.24 (m, 1H),






3.12 (m, 2H)



CC47

478.09 ([M + H]+)
8.06 (m, 2H), 7.61 (m,
3309, 1659,





4H), 7.48 (s, 2H),
1115, 808





7.44 (d, J = 8.0 Hz, 1H),






7.38 (m, 2H), 6.42 (m, 1H),






4.92 (s, 2H), 1.36 (m,






1H), 1.00 (m, 2H),






0.77 (m, 2H)



CC48

511.05 ([M + H]+)
8.06 (m, 2H), 7.61 (m,
3309, 1659,





3H), 7.48 (s, 2H),
1115, 808





7.44 (d, J = 8.0 Hz, 1H),






7.38 (m, 2H), 6.42 (m, 1H),






4.92 (s, 2H), 1.36 (m,






1H), 1.00 (m, 2H),






0.77 (m, 2H)



CC49
84-87
515.33 ([M + H]+).
8.06 (m, 1H), 7.98 (m,






1H), 7.61 (m, 3H),






7.48 (s, 2H), 7.44 (d, J = 8.0 Hz,






1H), 7.38 (m, 2H),






6.42 (m, 1H), 4.92 (s,






2H), 4.6 (br s, 1H),






4.24 (m, 1H), 3.21 (m, 2H),






1.2 (t, J = 4.6 Hz, 3H)



CC50
138-140
461.32 ([M − 1H]−)
9.81 (s, 1H), 7.90 (s,






1H), 7.84 (s, 2H),






7.34 (d, J = 8.4 Hz, 2H),






6.65 (d, J = 15.6 Hz, 1H),






6.61 (m, 1H), 6.57 (s,






1H), 6.48 (dd, J = 15.6,






8.8 Hz, 1H), 4.74 (m,






1H), 1.64 (m, 1H),






0.75 (m, 4H);



CC51
149-150
505.31 ([M − H]−)
7.56 (br s, 1H), 7.4 (s,






3H), 7.3 (m, 3H),






7.05 (br s, 1H), 6.8 (d, J = 6 Hz,






2H), 6.57 (m, 2H),






6.20 (m, 2H), 4.05 (m,






1H), 3.2 (q, J = 10.4 Hz,






2H)



CC52

464.87 ([M − H]−)
7.40 (s, 2H), 7.18 (s,
3309, 1659,





1H), 7.08 (s, 1H),
1115, 808





6.85 (m, 1H), 6.45 (m, 1H),






6.20 (m, 1H),






5.55 (s, 1H), 4.08 (m, 1H),






1.30-1.10 (m, 4H),






1.90 (m, 1H)



CC53

506 ([M + H]+)
7.40 (s, 2H), 7.18 (s,
3309, 1659,





1H), 7.08 (s, 1H),
1115, 808





6.85 (m, 1H), 6.45 (m, 1H),






6.20 (m, 1H),






5.55 (s, 1H), 4.08 (m, 1H),






3.21 (m, 2H)



CC54

504 ([M + H]+)
7.28 (s, 2H), 7.25 (m,






2H), 7.10 (d, J = 8.0 Hz,






2H), 6.89 (d, J = 11.4 Hz,






1H), 6.07 (br s, 1H),






6.01 (m, 1H), 4.51 (d, J = 5.8 Hz,






2H), 4.34 (m,






1H), 3.12 (q, J = 7.5 Hz,






2H)



DC1
93-97
398.05 ([M + H]+)
8.56 (s, 1H), 8.11 (s,






1H), 7.68 (d, J = 8.4 Hz,






2H), 7.54 (d, J = 8.4 Hz,






2H), 7.38 (t, J = 1.8 Hz,






1H), 7.29 (s, 2H),






6.62 (d, J = 15.6 Hz, 1H),






6.42 (dd, J = 15.6, 8.2 Hz,






1H), 4.15 (m, 1H)



DC2

363.0746 (363.075)
8.59 (s, 1H), 8.13 (s,
3121, 1524,





1H), 7.69 (d, J = 8.5 Hz,
1251, 1165,





2H), 7.55 (d, J = 8.5 Hz,
1119





2H), 7.41-7.29 (m,






4H), 6.64 (d, J = 15.7 Hz,






1H), 6.47 (dd, J = 15.9,






8.0 Hz, 1H),






4.17 (m, 1H)



DC3

329.1144 (329.114)
8.56 (s, 1H), 8.11 (s,
1521, 1246,





1H), 7.65 (d, J = 8.4 Hz,
1219, 1162,





2H), 7.52 (d, J = 8.3 Hz,
1152, 1107





2H), 7.40 (m, 5H),






6.61 (d, J = 15.8 Hz, 1H),






6.51 (dd, J = 15.9, 7.7 Hz,






1H), 4.18 (m, 1H)



DC4

364.11 ([M + H]+)
8.56 (s, 1H), 8.10 (s,
3147, 1528,





1H), 7.66 (d, J = 2.0 Hz,
1494, 1246,





2H), 7.52 (d, J = 8.8 Hz,
1165, 1108





2H), 7.38 (d, J = 2.4 Hz,






2H), 7.34 (d, J = 8.4 Hz,






2H), 6.61 (d, J = 16.0 Hz,






1H), 6.40 (dd, J = 16.0,






7.6 Hz, 1H),






4.15 (m, 1H)



DC5

344.25 ([M + H]+)
8.54 (s, 1H), 8.10 (s,
3122, 3047,





1H), 7.62 (d, J = 8.3 Hz,
1523, 1252,





2H), 7.50 (d, J = 8.4 Hz,
1160, 1107





2H), 7.25 (d, J = 8.3 Hz,






2H), 7.20 (d, J = 8.0 Hz,






2H), 6.60 (d, J = 16.0 Hz,






1H), 6.51 (dd, J = 16.0,






8.0 Hz, 1H),






4.15 (m, 1H), 2.37 (s, 3H)



DC6

360.28 ([M + H]+)
8.55 (s, 1H), 8.10 (s,
3124, 2936,





1H), 7.65 (d, J = 8.8 Hz,
1522, 1249,





2H), 7.52 (d, J = 8.8 Hz,
1160





2H), 7.32 (d, J = 8.8 Hz,






2H), 6.95 (d, J = 8.8 Hz,






2H), 6.60 (d, J = 16.0 Hz,






1H), 6.56 (dd, J = 16.0,






7.4 Hz, 1H),






4.15 (m, 1H), 3.82 (s, 3H)



DC7

348 ([M + H]+)
8.55 (s, 1H), 8.10 (s,
3141, 1512,





1H), 7.62 (d, J = 8.8 Hz,
1246, 1118





2H), 7.5 (d, J = 8.4 Hz,






2H), 7.38 (m, 2H),






7.12 (m, 2H), 6.61 (d, J = 16.0 Hz,






1H), 6.40 (dd,






J = 16.0, 7.6 Hz, 1H),






4.15 (m, 1H)



DC8

366.13 ([M + H]+)
8.57 (s, 1H), 8.11 (s,
3116, 1628,





1H), 7.65 (d, J = 7.2 Hz,
1524, 1252,





2H), 7.52 (d, J = 8.0 Hz,
1168, 1118





2H), 6.95 (m, 2H),






6.82 (m, 1H), 6.65 (d, J = 16.0 Hz,






1H), 6.50 (dd,






J = 16.0, 8.0 Hz, 1H),






4.15 (m, 1H)



DC9

348.11 ([M + H]+)
8.71 (s, 1H), 8.20 (s,
3115, 1525,





1H), 7.70 (d, J = 8.0 Hz,
1248, 1174





2H), 7.57 (d, J = 8.0 Hz,






2H), 7.40 (m, 1H),






7.19 (m, 3H), 6.60 (d, J = 16.0 Hz,






1H), 6.40 (dd,






J = 16.0, 8.4 Hz, 1H),






4.15 (m, 1H)



DC10

348.11 ([M + H]+)
8.75 (s, 1H), 8.20 (s,
3114, 1526,





1H), 7.72 (d, J = 8.4 Hz,
1259, 1238,





2H), 7.6 (d, J = 8.4 Hz,
1193, 1114





2H), 7.20-7.40 (m,






4H), 6.60 (d, J = 16.0 Hz,






1H), 6.40 (dd, J = 16.0,






8.0 Hz, 1H, ),






4.60 (m, 1H)



DC11
75.5-78.5
358.14 ([M + H]+)
8.55 (s, 1H), 8.10 (s,






1H), 7.65 (d, J = 8.8 Hz,






2H), 7.52 (d, J = 8.4 Hz,






2H), 7.01 (s, 3H),






6.60 (d, J = 16.0 Hz, 1H),






6.51 (dd, J = 16.0, 7.8 Hz,






1H), 4.15 (m, 1H),






2.34 (s, 6H)



DC12

398.05 ([M + H]+)
8.58 (s, 1H), 8.10 (s,
3055, 2930,





1H), 7.68 (d, J = 8.4 Hz,
1523, 1250,





2H), 7.53 (m, 4H),
1165





7.2 (s, 1H) 6.62 (d, J = 15.6 Hz,






1H), 6.44 (dd, J = 15.6,






8.0 Hz, 1H),






4.15 (m, 1H)



DC13

396.16 ([M + H]+)
8.58 (s, 1H), 8.10 (s,
3108, 1523,





1H), 7.62 (d, J = 8.4 Hz,
1249, 1166,





2H), 7.55 (m, 4H),
1127





7.25 (m, 1H), 6.64 (d, J = 16.0 Hz,






1H), 6.40 (dd,






J = 16.0, 8.0 Hz, 1H),






4.90 (m, 1H)



DC14

398.05 ([M + H]+)
8.58 (s, 1H), 8.10 (s,
3117, 2925,





1H), 7.62 (d, J = 8.4 Hz,
1526, 1246,





2H), 7.55 (m, 4H),
1172, 1117





7.25 (m, 1H), 6.67 (d, J = 16.0 Hz,






1H), 6.40 (dd,






J = 16.0, 8.0 Hz, 1H),






5.00 (m, 1H)



DC15

397.95 ([M + H]+)
8.58 (s, 1H), 8.10 (s,
3120, 1524,





1H), 7.66 (d, J = 8.0 Hz,
1267, 1176,





2H), 7.52 (m, 3H),
1112





7.40 (d, J = 8.0 Hz, 1H),






7.30 (dd, J = 8.4, 2.9 Hz,






1H), 6.64 (d, J = 16.0 Hz,






1H), 6.40 (dd, J = 16.0,






8.0 Hz, 1H),






4.90 (m, 1H)



DC16

466 ([M + H]+)
8.61 (s, 1H), 8.13 (s,






1H), 7.92 (s, 1H),






7.86 (s, 2H), 7.70 (d, J = 7.0 Hz,






2H), 7.54 (d, J = 7.0 Hz,






2H), 6.67 (d, J = 16.0 Hz,






1H), 6.46 (dd,






J = 16.0, 8.0 Hz, 1H),






4.35 (m, 1H)



DC17

430.06 ([M + H]+)
8.58 (s, 1H), 8.1 (s, 1H),
3122, 3076,





7.68 (d, J = 8.4 Hz, 2H),
2929, 1523,





7.54 (d, J = 8.4 Hz, 2H),
1250, 1168,





7.51 (s, 1H), 7.42 (s,
1114





1H), 6.68 (d, J = 16.0 Hz,






1H), 6.35 (dd, J = 16.0,






8.0, Hz, 1H),






4.98 (m, 1H)



DC18
92-95
429.91 ([M + H]+)
8.57 (s, 1H), 8.11 (s,






1H), 7.69 (d, J = 8.8 Hz,






2H), 7.54 (d, J = 8.4 Hz,






2H), 7.42 (s, 2H),






6.65 (d, J = 16.0 Hz, 1H),






6.40 (dd, J = 16.0, 8.0 Hz,






1H), 4.10 (m, 1H)



DC19
97-99
430.321 ([M + H]+)
8.58 (s, 1H), 8.12 (s,






1H), 7.68 (d, J = 8.0 Hz,






2H), 7.64 (s, 1H),






7.59 (s, 1H), 7.55 (m, 3H),






6.60 (d, J = 16.0 Hz,






1H), 6.40 (dd, J = 16.0,






8.0 Hz, 1H), 4.22 (m,






1H)



DC20

427.0463 (427.0466)
8.58 (s, 1H), 8.15 (s,
2937, 1524,





1H), 7.70 (d, J = 8.4 Hz,
1482, 1278,





2H), 7.58 (d, J = 8.4 Hz,
1249, 1166,





2H), 7.36 (s, 2H),
1112





6.62 (d, J = 16.0 Hz, 1H),






6.43 (dd, J = 16.0, 8.0 Hz,






1H), 4.12 (m, 1H),






3.88 (s, 3H)



DC21

412.04 ([M + H]+)
8.42 (s, 1H), 7.60 (d, J = 8.0 Hz,
3108, 1572,





2H), 7.50 (d, J = 8.0 Hz,
1531, 1242,





2H), 7.40 (s,
1172, 1104





1H), 7.22 (s, 2H),






6.60 (d, J = 16.0 Hz, 1H),






6.42 (dd, J = 16.0, 8.0 Hz,






1H), 4.15 (m, 1H),






2.5 (s, 3H)



DC22
147-149
441.01 ([M − H]−)
8.62 (s, 1H), 7.78 (d, J = 8.0 Hz,






2H), 7.60 (d, J = 8.0 Hz,






2H), 7.40 (s,






1H), 7.30 (s, 2H),






6.67 (d, J = 16.0 Hz, 1H),






6.48 (dd, J = 16.0, 8.0 Hz,






1H), 4.15 (m, 1H)



DC23

412.05 ([M + H]+)
7.95 (s, 1H), 7.35 (d, J = 8.0 Hz,
1112, 799





2H), 7.46 (d, J = 8.0 Hz,






2H), 7.39 (s,






1H), 7.29 (s, 2H),






6.67 (d, J = 16.0 Hz, 1H),






6.45 (dd, J = 16.0, 8.0 Hz,






1H), 4.12 (m, 1H),






2.51 (s, 3H)



DC24
133-134
440.03 ([M + H]+)
8.10 (s, 1H), 7.52 (d, J = 8.0 Hz,






2H),






7.42-7.38 (m, 3H), 7.28 (s, 2H),






6.67 (d, J = 16.0 Hz,






1H), 6.45 (dd, J = 16.0,






8.0 Hz, 1H), 4.16 (m,






1H), 2.79 (s, 3H)



DC25

442.02 ([M − H]−)
7.97 (s, 1H), 7.59 (d, J = 8.0 Hz,
1167, 1114,





2H), 7.53 (d, J = 8.0 Hz,
800





2H), 7.38 (m,






1H), 7.29 (s, 2H),






6.65 (d, J = 16.0 Hz, 1H),






6.42 (dd, J = 16.0, 8.0 Hz,






1H), 4.17 (m, 1H),






2.74 (s, 3H)



DC26

464.03 ([M − H]−)
8.12 (s, 1H), 7.49 (d, J = 8.0 Hz,
1689, 1253,





2H),
1166, 1114,





7.40-7.37 (m 3H), 7.28 (s, 2H),
979, 964





6.66 (d, J = 16.0 Hz,






1H), 6.44 (dd, J = 16.0,






8.0 Hz, 1H), 4.14 (m,






1H), 3.22 (m, 1H),






1.09-1.16 (m, 4H)



DC27

473.94 ([M − H]−)
8.19 (s, 1H), 7.64 (d, J = 7.2 Hz,
1571, 1331,





2H), 7.55 (d, 7.2 Hz,
1170, 1113,





2H), 7.39 (s, 1H),
764





7.30 (s, 2H), 6.62 (d, J = 16.0 Hz,






1H), 6.42 (dd,






J = 8.0, 16.0 Hz, 1H),






4.18 (m, 1H), 3.58 (s,






3H)



DC28

421.22 ([M + H]+)
8.79 (s, 1H), 8.18 (s,
3126, 2233,





1H), 7.80 (m, 3H),
1516, 1250,





7.52 (m, 2H), 7.24 (m, 1H),
1165, 1109





6.63 (d, J = 16.0 Hz,






1H), 6.54 (d, J = 16.0,






7.6 Hz, 1H), 4.19 (m,






1H)



DC29

421.22 ([M + H]+)
8.80 (s, 1H), 8.2 (s, 1H),
3005, 1716,





7.75-7.82 (m, 3H),
1363, 1223





7.41 (t, J = 2 Hz, 1H),






7.26 (m, 2H), 6.65 (d, J = 16.0 Hz,






1H),






6.52 (dd, J = 16.0, 7.6 Hz,






1H), 4.16 (m, 1H)



DC30

489.17 ([M + H]+)
8.81 (s, 1H), 8.20 (s,
2964, 2234,





1H), 7.94 (s, 1H),
1289, 1166,





7.85 (m, 3H), 7.79 (m, 2H),
1136





6.70 (d, J = 16.0 Hz,






1H), 6.58 (dd, J = 16.0,






8.0 Hz, 1H), 4.35 (m,






1H)



DC31
117-118
455.27 ([M + H]+)
8.80 (s, 1H), 8.20 (s,






1H), 7.82 (m, 3H),






7.4 (s, 2H), 6.62 (d, J = 16.0 Hz,






1H), 6.52 (dd, J = 16.0,






8.0 Hz, 1H),






4.18 (m, 1H)



DC32

388.0705 (388.0703)
8.82 (s, 1H), 8.22 (s,
3126, 2234,





1H), 7.82-7.78 (m, 3H),
1520, 1280,





7.38-7.30 (m, 3H),
1164, 1112





6.62 (d, J = 16.1 Hz, 1H),






6.56 (dd, J = 16.1, 6.8 Hz,






1H), 4.18 (m, 1H)



DC33

455.22 ([M − H]−)
8.80 (s, 1H), 8.20 (s,
3122, 3086,





1H), 7.82-7.80 (m, 3H),
2234, 1517,





7.70-7.50 (m, 3H),
1327, 1168,





6.65 (d, J = 16.9 Hz, 1H),
1113





6.54 (dd, J = 16.9, 6.8 Hz,






1H), 4.25 (m, 1H)



DC34

452.0412 (452.0419)
8.85 (s, 1H), 8.23 (br s,
3122, 2934,





1H), 7.83-7.78 (m, 3H),
2231, 1516,





7.33 (s, 2H), 6.69 (d, J = 14.9 Hz,
1480, 1248,





1H), 6.50 (dd,
1211, 1165,





J = 14.9, 7.2 Hz, 1H),
1111





4.15 (m, 1H), 3.90 (s,






3H)



DC35

439.01 ([M − H]−)
8.60 (s, 1H), 8.20 (s,
2233, 1518,





1H), 7.82 (m, 3H),
1250, 1169,





7.28 (m, 2H), 6.65 (d, J = 16.0 Hz,
1035, 817





1H), 6.48 (dd,






J = 16.0, 8.0 Hz, 1H),






4.20 (m, 1H)



DC36

437.25 ([M + H]+)
8.70 (s, 1H), 7.80 (m,
2927, 2233,





3H), 7.40 (s, 1H),
1572, 1531,





7.28 (s, 2H), 6.63 (d, J = 16.0 Hz,
1248, 1166,





1H), 6.50 (dd, J = 16.0,
1112





8.0 Hz, 1H),






4.18 (m, 1H), 2.50 (s, 1H)



DC37
109-111
466.10 ([M − H]−)
8.86 (s, 1H), 7.89 (m,






3H), 7.40 (s, 1H),






7.30 (s, 2H), 6.68 (d, J = 16.0 Hz,






1H), 6.57 (dd, J = 16.0,






8.0 Hz, 1H),






4.18 (m, 1H)



DC38
96-98
436.11 ([M − H]−)
8.58 (s, 1H), 7.75 (m,






3H), 7.40 (s, 1H),






7.28 (s, 2H), 6.61 (d, J = 16.0 Hz,






1H), 6.42 (dd, J = 16.0,






8.2 Hz, 1H),






4.40 (br s, 2H), 4.15 (m, 1H)



DC39
224-226
480.30 ([M + H]+)
8.65 (s, 1H), 8.18 (br s,
3352, 2237,





1H), 7.80-7.70 (m, 3H),
1707, 1163,





7.40 (s, 1H), 7.27 (s,
841





2H), 7.36 (m, 1H),






7.28 (m, 2H), 6.60 (d, J = 16.8 Hz,






1H), 6.47 (m,






1H), 4.16 (m, 1H),






2.40 (br s, 3H)



DC40
70-73
436.11 ([M − 2H]−)
8.86 (s, 1H), 7.88 (m,






3H), 7.44 (s, 2H),






6.67 (d, J = 16.0 Hz, 1H),






6.56 (dd, J = 16.0 7.6 Hz,






1H), 4.19 (m, 1H)



DC41
72-75
469.95 ([M − H]−)
(DMSO-d6) 8.72 (s,






1H), 8.26 (s, 1H),






8.01 (d, J = 8.4 Hz, 1H),






7.91 (s, 2H), 7.77 (d, J = 8.4 Hz,






1H), 6.42 (dd, J = 15.6,






9.2 Hz, 1H),






6.83 (d, J = 15.6 Hz, 1H),






5.87 (s, 2H), 4.89 (m,






1H)



DC42
104-107
609.98 ([M + H]+)
8.78 (s, 2H), 7.83 (s,
2234, 1714,





1H), 7.80 (m, 2H),
1114, 807





7.42 (s, 2H), 6.65 (d, J = 16.4 Hz,






1H), 6.51 (dd, J = 16.4,






7.8 Hz, 1H),






4.17 (m, 1H), 42.16 (m, 2H),






1.25 (m, 4H), 1.00 (m,






4H),



DC43
109-112
540.04 ([M + H]+)
(DMSO-d6) 10.94 (br s,
3233, 2233,





1H), 8.36 (s, 1H),
1699, 1114,





8.08 (m, J = 8.4 Hz, 1H),
807





7.91 (s, 2H), 7.84 (d, J = 8.4 Hz,






1H), 7.13 (dd, J = 15.6,






9.2 Hz, 1H),






6.87 (d, J = 15.6 Hz,






1H), 4.92 (m, 1H),






1.99 (br s, 1H), 0.82 (s, 4H)



DC44

435.26 [M − H]−
8.33 (s, 1H), 8.23 (s,
2236, 1510,





1H), 7.66 (s, 1H),
1114, 801





7.60 (s, 1H), 7.41 (m, 1H),






7.28 (m, 2H), 6.62 (d, J = 16.0 Hz,






1H),






6.51 (dd, J = 16.0, 7.8 Hz,






1H), 4.16 (m, 1H),






2.20 (s, 3H)



DC45
75-78
468.87 [M − H]−
8.36 (s, 1H), 8.23 (s,






1H), 7.66 (s, 1H),






7.60 (s, 1H), 7.41 (s, 2H),






6.62 (d, J = 16.4 Hz,






1H), 6.51 (dd, J = 16.4,






7.6 Hz, 1H), 4.16 (m,






1H), 2.20 (s, 3H)



DC46

411.4 ([M]+)
8.83 (s, 1H), 8.21 (s,
13C NMR (δ)3





1H), 7.83 (d, J = 8.5 Hz,
155.63,





1H), 7.61 (d, J = 1.9 Hz,
153.27,





1H), 7.52 (dd, J = 8.4,
153.12,





1.9 Hz, 1H), 7.28 (d, J = 3.8 Hz,
143.01,





2H), 6.93 (d, J = 11.5 Hz,
137.89,





1H),
136.25,





6.26-6.20 (m, 1H), 4.22 (m,
134.03,





1H)
133.88,






132.23,






131.23,






131.18,






129.20,






126.17,






125.04,






124.99


DC47
139-141
474.16 ([M − H]−)
8.51 (s, 1H), 8.14 (s,






1H), 7.75 (s, 1H),






7.5 (m, 2H), 7.4 (s, 1H),






7.30 (m, 2H), 6.60 (d, J = 16.0 Hz,






1H),






6.50 (dd, J = 16.0, 8.0 Hz,






1H), 4.15 (m, 1H)



DC48
124-126
414.05 [M − H]−
8.69 (s, 1H), 8.14 (s,






1H), 7.96 (d, J = 4.8 Hz,






1H), 7.39-7.27 (m, 5H),






6.95 (d, J = 16.0 Hz,






1H), 6.51 (dd, J = 16.0,






7.6 Hz, 1H), 4.13 (m,






1H)



DC49
81-83
463.96 [M − H]−
8.57 (s, 1H), 8.14 (s,






1H), 7.60 (m, 2H),






7.44 (m, 3H), 6.95 (d, J = 16.0 Hz,






1H), 6.51 (dd,






J = 16.0, 7.6 Hz, 1H),






4.13 (m, 1H)



DC50
140-143
430.07 [M − H]−)
8.56 (s, 1H), 8.13 (s,
1110, 803





1H), 7.59 (d, J = 1.2 Hz,






2H), 7.44 (m, 2H),






7.28 (m, 2H), 6.61 (d, J = 16.0 Hz,






1H), 6.47 (dd,






J = 16.0, 8.0 Hz, 1H),






4.15 (m, 1H)



DC51
118-121
464.22 ([M − H]−)
8.32 (s, 1H), 8.15 (s,






1H), 7.82 (s, 1H),






7.73 (d, J = 8.4 Hz, 1H),






7.53 (d, J = 8.4 Hz, 1H),






7.41 (s, 1H), 7.29 (s, 2H),






6.70 (d, J = 15.6 Hz,






1H), 6.50 (dd, J = 15.6,






8.0 Hz, 1H), 4.20 (m,






1H)



DC52


9.99 (s, 1H), 8.42 (s,
3123, 3079,





1H), 8.12 (s, 1H),
2925, 1692,





8.01 (s, 1H), 7.68 (m, 1H),
1571, 1512,





7.44 (m, 1H), 7.33 (m,
1253, 1164,





1H), 7.22 (s, 2H),
1111





6.62 (d, J = 16.7 Hz, 1H),






6.45 (dd, J = 16.7, 9.3 Hz,






1H), 4.10 (m, 1H)



DC53


8.30 (m, 1H), 8.00 (br s,
3250, 3043,





1H), 7.75 (m, 1H),
1683, 1116





7.68 (m, 1H), 7.55 (m, 1H),






7.36 (m, 1H), 7.28 (m,






2H), 6.70 (m, 1H),






6.58 (br s, 1H), 6.33 (m, 1H),






5.88 (m, 2H), 4.10 (m,






1H)



DC54
56-58
441.07 ([M − H]−)
8.40 (s, 1H), 8.13 (s,






1H), 8.02 (s, 1H),






7.76 (d, J = 8.4 Hz, 1H),






7.59 (d, J = 8.0 Hz, 1H),






7.4 (s, 1H), 7.29 (m, 2H),






6.69 (d, J = 15.6 Hz,






1H), 6.57 (dd, J = 15.6,






7.8 Hz, 1H), 4.15 (m,






1H)



DC55

412.97 ([M + H]+)
8.37 (s, 1H), 8.18 (s,






1H), 7.39 (s, 1H),






7.30 (m, 2H), 7.19 (d, J = 8.0 Hz,






1H), 6.90 (m, 2H),






6.55 (d, J = 15.6 Hz,






1H), 6.38 (dd, J = 15.6,






8.2 Hz, 1H), 4.20 (m,






1H), 2.50 (br s, 2H)



DC56
175-177
453 ([M − H]−)
9.59 (br s, 1H), 8.55 (s,






1H), 8.47 (s, 2H),






8.23 (s, 1H), 7.30 (m, 4H),






6.62 (d, J = 16.0 Hz,






1H), 6.40 (dd, J = 16.0,






8.0 Hz, 1H), 4.15 (m,






1H), 2.20 (s, 3H)



DC57

426.0627 (426.0626)
8.33 (s, 1H), 8.16 (s,
3342, 3112,





1H), 7.38 (s, 1H),
2931, 1606,





7.29 (s, 2H), 7.15 (d, J = 7.6 Hz,
1583, 1574,





1H), 6.80 (d, J = 7.6 Hz,
1528, 1153





1H), 6.74 (m, 1H),






6.60 (d, J = 15.6 Hz,






1H), 6.35 (dd, J = 15.6,






8.4 Hz, 1H), 5.40 (br s,






1H), 4.15 (m, 1H),






2.90 (s, 3H)



DC58
94-97
440.0424 (440.0419)
(DMSO-d6) 8.76 (s,
3403, 3304,





1H), 8.16 (s, 1H),
3178, 1674,





7.90 (br s, 1H), 7.83 (s, 1H),
1571, 1169,





7.70 (d, J = 7.9 Hz, 1H),
1108





7.71-7.67 (m, 3H),






7.58 (d, J = 7.9 Hz, 1H),






7.52 (br s, 1H), 7.00 (dd, J = 15.8,






8.7 Hz, 1H),






6.85 (d, J = 15.8 Hz, 1H),






4.85 (m, 1H)



DC59
87-90

(DMSO-d6) 9.00 (s,






1H), 8.63 (s, 1H),






8.17 (s, 1H), 7.70-7.59 (m,






5H), 7.00 (dd, J = 16.2,






9.7 Hz, 1H), 6.85 (d, J = 16.2 Hz,






1H), 5.90 (br s






2H), 4.83 (m, 1H)



DC60

469.0577 (469.0572)
8.32 (s, 1H), 8.10 (s,
2987, 1725,





1H), 7.97 (s, 1H),
1518, 1275,





7.65 (d, J = 8.1 Hz, 1H),
1166, 1113





7.47 (d, J = 8.1 Hz, 1H),






7.40 (m, 1H), 7.28 (s, 2H),






6.62 (d, J = 16.5 Hz,






1H), 6.49 (dd, J = 16.5,






7.7 Hz, 1H),






4.23-4.04 (m, 3H), 1.15 (t, J = 8.0 Hz,






3H)



DC61
130-132
442.15 ([M + H]+)
(DMSO-d6) 9.90 (s,






1H), 8.17 (s, 1H),






8.15 (m, 1H), 7.90 (m, 1H),






7.71 (m, 2H), 7.67 (m,






1H), 7.62 (d, J = 7.3 Hz,






1H), 7.03 (dd, J = 16.5,






8.3 Hz, 1H), 6.62 (d, J = 16.5 Hz,






1H), 4.87 (m,






1H)



DC62

412.10 ([M + H]+)
8.27 (s, 1H), 8.23 (s,
1513, 1252,





1H), 7.40 (m, 3H),
1166, 1112,





7.30 (m, 3H), 6.64 (d, J = 16.0 Hz,
801





1H), 6.45 (dd,






J = 16.0, 8.0 Hz, 1H),






4.19 (m, 1H), 2.21 (s,






3H)



DC63

446.01 ([M + H]+)
8.26 (s, 1H), 8.12 (s,
2928,





1H), 7.42 (s, 2H),
2525, 1249,





7.18-7.28 (m, 3H), 6.62 (d, J = 15.6 Hz,
1169, 1114,





1H),
809





6.39 (dd, J = 15.6, 9.4 Hz,






1H), 4.10 (m, 1H),






2.25 (s, 3H)



DC64

475.03 ([M + H]+)
8.84 (d, J = 5.8 Hz, 2H),
1683, 1167,





8.33 (s, 1H), 8.20 (s,
650, 479





1H), 7.75 (m, 1H),






7.60 (d, J = 28.6 Hz, 1H),






7.58-7.48 (m, 3H),






7.42 (m, 1H), 7.28 (s, 2H),






6.71 (d, J = 16.9 Hz,






1H), 6.39 (dd, J = 16.9,






8.2 Hz, 1H), 4.15 (m,






1H)



DC65

412.05 ([M + H]+)
8.55 (s, 1H), 8.12 (s,
722, 111





1H), 7.55 (m, 3H),






7.39 (m, 1H), 7.30 (d, J = 1.6 Hz,






1H), 6.85 (d, J = 16.0 Hz,






1H), 6.41 (dd,






J = 16.0, 8.0 Hz, 1H),






4.17 (m, 1H), 2.40 (s,






3H)



DC66
60-61
468.26 ([M + H]+)
8.59 (s, 1H), 8.14 (s,






1H), 7.94 (s, 1H),






7.70 (d, J = 8.0 Hz, 1H),






7.61 (d, J = 8.0 Hz, 1H),






7.43 (s, 2H), 7.23 (d, J = 16.0 Hz,






1H), 6.41 (dd, J = 16.0,






8.0 Hz, 1H),






4.20 (m, 1H)



DC67
133-134
432.30 ([M + H]+)
8.59 (s, 1H), 8.12 (s,
800, 114





1H), 7.78 (br s, 1H),






7.71 (m, 1H), 7.62 (m,






1H), 7.39 (s, 1H),






7.32 (s, 2H), 7.03 (d, J = 16.0 Hz,






1H), 6.43 (dd, J = 16.0,






8.0 Hz, 1H),






0.21 (m, 1H)



DC68

412.03 ([M + H]+)
8.71 (s, 1H), 8.18 (s,






1H), 7.71 (d, J = 8.0 Hz,






2H), 7.55 (d, J = 8.0 Hz,






2H), 7.37 (s, 1H),






7.28 (m, 2H), 6.08 (d, J = 16.0 Hz,






1H), 4.26 (m,






1H), 2.05 (s, 3H)



DC69
162-168
414.03 ([M + H]+)
8.56 (s, 1H), 8.11 (s,






1H), 7.70 (d, J = 8.5 Hz,






2H), 7.56 (d, J = 8.5 Hz,






2H), 7.54 (m, 2H),






7.40 (m, 1H), 6.91 (d, J = 16.5 Hz,






1H), 6.66 (d, J = 16.5 Hz,






1H)



DC70
 99-103
428.05 ([M + H]+)
8.58 (s, 1H), 8.13 (s,






1H), 7.73 (d, J = 8.7 Hz,






2H), 7.60 (d, J = 8.7 Hz,






2H), 7.46 (m, 2H),






7.42 (m, 1H), 6.85 (d, J = 16.2 Hz,






1H), 6.40 (d, J = 16.2 Hz,






1H), 3.42 (s,






3H)





a1H NMR spectral data were acquired using a 400 MHz instrument in CDCl3 except where noted. HRMS data are noted observed value (theoretical value).





















mp





Compound
(° C.);


IR (cm−1);


Number
[α]D25
ESIMS
1H NMR (δ)a
19F NMR (δ)







F4

642.99 ([M + H]+)
(300 MHz, DMSO-d6)
3460, 1677,





δ 8.58 (s, 1H), 8.20 (t, J = 6.6 Hz,
1165, 557





1H),





7.98-7.89 (m, 4H), 7.80 (d, J = 8.1 Hz,





1H),





7.04 (dd, J = 15.6, 8.7 Hz,





1H), 6.88 (d, J = 15.6 Hz,





1H), 4.88-4.78 (m,





1H), 3.89-3.82 (m, 2H),





1.40 (s, 6H)


F5

640.9 ([M + H]+)
7.62 (d, J = 1.7 Hz,
3288, 1644,





1H), 7.53 (d, J = 7.8 Hz,
1162





1H),





7.42-7.29 (m, 3H), 6.91 (t, J = 6.7 Hz,





1H), 6.54 (bs, 1H)





6.53 (d, J = 15.9 Hz,





1H), 6.39 (dd, J = 15.9,





7.8 Hz, 1H), 4.74 (q, J = 7.1 Hz,





1H), 4.10 (m,





1H), 4.05-3.72 (m,





2H), 1.53 (d, J = 7.0 Hz,





3H)


F6

640.9 ([M + H]+)
7.62 (d, J = 1.6 Hz,
3288, 1645,





1H), 7.53 (d, J = 8.0 Hz,
1164





1H), 7.41 (s, 2H),





7.38 (dd, J = 8.0, 1.7 Hz,





1H), 6.86 (t, J = 6.2 Hz,





1H),





6.57-6.49 (m, 2H), 6.40 (dd, J = 15.9,





7.8 Hz, 1H),





4.74 (m, 1H),





4.15-4.04 (m, 1H),





4.00-3.81 (m, 2H), 1.53 (d, J = 7.1 Hz,





3H)


F7

574.92 ([M + H]+)
(300 MHz, DMSO-d6)
3412, 1685,





δ 8.56 (t, J = 6.3 Hz,
1163, 809





1H), 8.43 (d, J = 4.5 Hz,





1H), 7.89 (s, 2H),





7.44-7.34 (m, 3H),





6.88 (dd, J = 15.6, 8.4 Hz,





1H), 6.75 (d, J = 15.6 Hz,





1H), 4.85-4.79 (m,





1H), 4.49-4.44 (m, 1H),





3.99-3.83 (m, 2H),





2.33 (s, 3H), 1.34 (d, J = 7.2 Hz,





3H)


F8

652.95 ([M + H]+)
(400 MHz, DMSO-d6)
3291, 1647,





δ 8.62 (t, J = 6.0 Hz,
1165, 808,





1H), 8.59 (d, J = 7.6 Hz,
565





1H), 7.92-7.91 (m,





3H), 7.60 (d, J = 7.6 Hz,





1H), 7.38 (d, J = 8.1 Hz,





1H), 6.99 (dd, J = 15.6,





9.2 Hz, 1H),





6.77 (d, J = 15.6 Hz,





1H), 4.85-4.80 (m, 1H),





4.41-4.36 (m, 1H),





4.05-3.99 (m, 1H),





3.91-3.84 (m, 1H),





1.73-1.63 (m, 2H),





0.99 (t, J = 7.6 Hz, 3H)


F8A

650.99 ([M − H]−)
(300 MHz, DMSO-d6)
3289, 1646,





δ 8.64-8.57 (m, 2H),
1164, 808.





7.92-7.91 (m, 3H),
725, 649





7.60 (d, J = 7.5 Hz, 1H),





7.38 (d, J = 7.5 Hz,





1H), 7.01 (dd, J = 15.6,





9.0 Hz, 1H), 6.78 (d, J = 15.6 Hz,





1H),





4.86-4.80 (m, 1H),





4.42-4.35 (m, 1H), 4.06-3.84 (m,





2H), 1.76-1.62 (m, 2H),





0.93 (t, J = 7.2 Hz, 3H).


F9

575.04 ([M + H]+)
(400 MHz, DMSO-d6)
3407, 1685,





δ 8.56 (t, J = 6.0 Hz,
1161, 808





1H), 8.44 (d, J = 7.2 Hz,





1H), 7.89 (s, 2H),





7.45 (s, 1H),





7.41-7.35 (m, 2H), 6.87 (dd, J = 16.0,





9.2 Hz, 1H),





6.74 (d, J = 15.2 Hz, 1H),





4.85-4.80 (m, 1H),





4.48-4.44 (m, 1H),





4.03-3.85 (m, 2H),





2.33 (s, 3H), 1.31 (d, J = 7.2 Hz,





3H)


F10

638.84 ([M + H]+)
(400 MHz, DMSO-d6)
3415, 1652,





δ 8.61 (d, J = 7.2 Hz,
1162, 807,





1H), 8.52 (t, J = 6.0 Hz,
561





1H), 7.88-7.87 (m, 3H),





7.56 (d, J = 7.6 Hz,





1H), 7.38 (d, J = 8.0 Hz,





1H), 6.96 (dd, J = 16.6,





9.2 Hz, 1H),





6.73 (d, J = 15.6 Hz, 1H),





4.81-4.77 (m, 1H),





4.46-4.42 (m, 1H),





4.00-3.81 (m, 2H),





1.27 (d, J = 7.2 Hz, 3H)


F11

638.90 ([M + H]+)
(400 MHz, DMSO-d6)
3415, 1652,





δ 8.61 (d, J = 7.2 Hz,
1162, 807,





1H), 8.52 (t, J = 6.0 Hz,
561





1H), 7.88-7.87 (m, 3H),





7.56 (d, J = 7.6 Hz,





1H), 7.38 (d, J = 8.0 Hz,





1H), 6.96 (dd, J = 16.6,





9.2 Hz, 1H),





6.73 (d, J = 15.6 Hz, 1H),





4.81-4.77 (m, 1H),





4.46-4.42 (m, 1H),





4.00-3.81 (m, 2H),





1.27 (d, J = 7.2 Hz, 3H)


F12

638.90 ([M + H]+)
(400 MHz, DMSO-d6)
3418, 1646,





δ 8.65 (d, J = 7.2 Hz,
1163, 808,





1H), 8.56 (t, J = 8.0 Hz,
564





1H), 7.92 (s, 1H),





7.91 (s, 2H), 7.60-7.58 (m,





1H), 7.42 (d, J = 7.6 Hz,





1H), 6.99 (dd, J = 15.6,





8.0 Hz, 1H),





6.77 (d, J = 15.6 Hz, 1H),





4.83-4.76 (m, 1H),





4.52-4.45 (m, 1H),





4.06-3.82 (m, 2H),





1.33 (d, J = 8.0 Hz, 3H)


F13

638.96 ([M + H]+)
(400 MHz, DMSO-d6)
3418, 1646,





δ 8.65 (d, J = 7.2 Hz,
1163, 808,





1H), 8.56 (t, J = 8.0 Hz,
564





1H), 7.92 (s, 1H),





7.91 (s, 2H), 7.60-7.58 (m,





1H), 7.42 (d, J = 7.6 Hz,





1H), 6.99 (dd, J = 15.6,





8.0 Hz, 1H),





6.77 (d, J = 15.6 Hz, 1H),





4.83-4.76 (m, 1H),





4.52-4.45 (m, 1H),





4.06-3.82 (m, 2H),





1.33 (d, J = 8.0 Hz, 3H)


F14

673.31 ([M + H]+)
(300 MHz, CDCl3) δ
3422, 1640,





7.91 (s, 1H), 7.82 (s,
1169, 528





2H), 7.62 (s, 1H),





7.53 (d, J = 7.5 Hz, 1H),





7.40 (d, J = 8.1 Hz, 1H),





6.80 (bs, 1H), 6.62 (s,





1H), 6.55 (d, J = 16.0 Hz,





1H), 6.50 (dd, J = 16.0,





8.0 Hz, 1H),





4.73-4.70 (m, 1H),





4.40-4.25 (m, 1H),





3.95-3.92 (m, 2H), 1.56 (d, J = 7.5 Hz,





3H)


F15

589.00 ([M + H]+)
(400 MHz, DMSO-d6)
3295, 1682,





δ 8.58 (t. J = 8.8 Hz,
1164, 80





1H), 8.32 (d, J = 8.0 Hz,





1H), 7.85 (s, 2H),





7.42 (s, 1H), 7.37 (d, J = 8.0 Hz,





1H), 7.31 (d,





J = 7.6 Hz, 1H),





6.83 (dd, J = 15.6 Hz, 8.8 Hz,





1H), 6.71 (d, J = 15.6 Hz,





1H),





4.77-4.81 (m, 1H), 4.30-4.35 (m,





1H), 3.94-4.00 (m, 1H),





3.80-3.86 (m, 1H),





2.29 (s, 3H), 1.71-1.60 (m,





2H), 0.88 (t, J = 7.6 Hz,





3H)


F15A

588.9 ([M + H]+)
(300 MHz, DMSO-d6)
3290, 1646,





δ 8.61 (t, J = 6.0 Hz,
1165, 808.





1H), 8.35 (d, J = 7.5 Hz,
725, 651





1H), 7.89 (s, 2H),





7.45 (s, 1H), 7.41 (d, J = 8.4 Hz,





1H), 7.34 (d,





J = 7.8 Hz, 1H),





6.88 (dd, J = 15.9, 8.7 Hz,





1H), 6.75 (d, J = 15.9 Hz,





1H), 4.85-4.79 (m,





1H), 4.40-4.32 (m, 1H),





4.04-3.82 (m, 2H),





2.33 (s, 3H), 1.76-1.62 (m,





2H), 0.91 (t, J = 7.5 Hz,





3H)


F16

643.06 ([M + H]+)
(400 MHz, DMSO-d6)
3292, 1652,





δ 8.65-8.60 (m, 2H),
1167, 809





7.95 (s, 1H),





7.89-7.82 (m, 3H), 7.47 (d, J = 8.0 Hz,





1H), 7.04 (dd, J = 15.6,





9.2 Hz, 1H),





6.85 (d, J = 15.9 Hz,





1H), 4.85-4.80 (m, 1H),





4.38-4.33 (m, 1H),





4.01 (m, 2H), 1.72-1.58 (m,





2H), 0.86 (t, J = 7.6 Hz,





3H)


F16A

640.9 ([M − H]−)
(300 MHz, DMSO-d6)
3290, 1651,





δ 8.66-8.62 (m, 2H),
1166, 809





7.98 (s, 1H),





7.92-7.87 (m, 3H), 7.51 (d, J = 7.8 Hz,





1H), 7.04 (dd, J = 15.6,





9.0 Hz, 1H),





6.89 (d, J = 15.6 Hz,





1H), 4.86-4.79 (m, 1H),





4.41-4.37 (m, 1H),





4.05-3.87 (m, 2H),





1.72-1.63 (m, 2H),





0.90 (t, J = 6.9 Hz, 3H)


F17

628.95 ([M + H]+)
(400 MHz, DMSO-d6)
3299, 1686,





δ 8.55 (t, J = 6.4 Hz,
1165, 568





1H), 8.42 (d, J = 7.6 Hz,





1H), 7.89 (s, 1H),





7.82 (s, 2H), 7.45 (s,





1H), 7.41-7.35 (m, 2H),





6.85 (dd, J = 16.0 Hz,





8.8 Hz, 1H), 6.74 (d, J = 15.6 Hz,





1H),





4.81-4.76 (m, 1H),





4.48-4.44 (m, 1H), 3.99-3.84 (m,





2H), 2.33 (s, 3H),





1.30 (d, J = 7.6 Hz, 3H)


F18

629.0 ([M + H]+)
(300 MHz, DMSO-d6)
3407, 1713,





δ 8.76 (d, J = 7.8 Hz,
1160, 807





1H), 8.61 (t, J = 12.9 Hz,





1H), 7.98 (s, 1 H),





7.92-7.88 (m, 3H),





7.56 (d, J = 8.1 Hz, 1H),





7.10 (dd, J = 16.2, 9.3 Hz,





1H), 6.89 (d, J = 16.0 Hz,





1H),





4.89-4.83 (m, 1H), 4.51-4.47 (m,





1H), 4.01-3.88 (m, 2H),





1.29 (d, J = 7.2 Hz, 3H)


F19

692.88 ([M + H]+)
(400 MHz, DMSO-d6)
3404, 1646,





δ 8.61 (d, J = 7.2 Hz,
1165, 565





1H), 8.52 (t, J = 12.8 Hz,





1H), 7.88 (s, 1H),





7.85 (s, 1H), 7.80 (s,





2H), 7.56 (d, J = 6.8 Hz,





1H), 7.38 (d, J = 8.0 Hz,





1H), 6.95 (dd, J = 15.6,





9.2 Hz, 1H),





6.72 (d, J = 15.6 Hz,





1H), 4.77-4.72 (m, 1H),





4.46-4.42 (m, 1H),





3.98-3.82 (m, 2H),





1.27 (d, J = 6.8 Hz, 3H)


F20

629.29 ([M + H]+)
(400 MHz, DMSO-d6)
3407, 1679,





δ 8.75 (d, J = 7.8 Hz,
1165, 808





1H), 8.59 (t, J = 6.6 Hz,





1H), 7.98-7.88 (m, 4H),





7.56 (d, J = 8.1 Hz,





1H), 7.09 (dd, J = 15.6,





8.7 Hz, 1H), 6.89 (d, J = 15.9 Hz,





1H),





4.89-4.83 (m, 1H),





4.52-4.47 (m, 1H), 4.01-3.88 (m,





2H), 1.30 (d, J = 6.9 Hz,





3H)


F20A
[α]D25 = +49.2 (c,
628.89 ([M + H]+)
(400 MHz, DMSO-d6)
3315, 1657,



1%

δ 8.74 (d, J = 7.6 Hz,
1167, 700



in

1H), 7.98 (s, 1H),



CH2Cl2)

7.92-7.89 (m, 3H), 7.56 (d,





J = 8.4 Hz, 1H),





7.08 (dd, J = 15.6, 8.8 Hz,





1H), 6.88 (d, J = 15.6 Hz,





1H),





4.88-4.83 (m, 1H),





4.51-4.48 (m, 1H),





3.99-3.86 (m, 2H), 1.49 (d, J = 6.8 Hz,





3H)


F20B
[α]D25 = −38.8 (c,
628.89 ([M + H]+)
(400 MHz, DMSO-d6)
3315, 1657,



1% in

δ 8.74 (d, J = 7.6 Hz,
1167, 700



CH2Cl2)

1H), 7.98 (s, 1H),





7.92-7.89 (m, 3H), 7.56 (d,





J = 8.4 Hz, 1H),





7.08 (dd, J = 15.6, 8.8 Hz,





1H), 6.88 (d, J = 15.6 Hz,





1H),





4.88-4.83 (m, 1H),





4.51-4.48 (m, 1H),





3.99-3.86 (m, 2H), 1.49 (d, J = 6.8 Hz,





3H)


F20C
61-70
629 ([M + H]+)
7.64 (t, J = 6.4 Hz,
19F NMR





1H), 7.52 (d, J = 7.9 Hz,
(376 MHz,





1H), 7.42 (s, 1H),
CDCl3) δ −59.22,





7.34 (d, J = 2.9 Hz,
amide





3H), 6.64 (m, 1H),
rotamers −69.43





6.91 (d, J = 11.4 Hz, 1H),
and −69.45,





6.19 (dd, J = 11.4, 10.3 Hz,
−72.60





1H), 4.94 (p, J = 7.1 Hz,





1H), 4.18 (q, J = 8.8 Hz,





1H),





3.95-3.71 (m, 2H), 1.52 (d, J = 6.9 Hz,





3H)


F21

682.98 ([M + H]+)
(400 MHz, DMSO-d6)
3302, 1656,





δ 8.70 (d, J = 7.2 Hz,
1166, 557





1H), 8.55 (t, J = 6.4 Hz,





1H), 7.94 (s, 1H),





7.87-7.81 (m, 4H), 7.52 (d, J = 8.4 Hz,





1H),





7.04 (dd, J = 15.6, 9.2 Hz,





1H), 6.84 (d, J = 15.6 Hz,





1H), 4.80-4.75 (m,





1H), 4.47-4.44 (m, 1H),





3.97-3.78 (m, 2H),





1.29 (d, J = 7.6 Hz, 3H)


F22

605.32 ([M + H]+)
(300 MHz, DMSO-d6)
3412, 1645,





δ 8.65 (d, J = 7.5 Hz,
1164, 597





1H), 8.55 (t, J = 8.1 Hz,





1H), 7.93-7.87 (m, 3H),





7.78 (d, J = 8.1 Hz,





1H), 7.71-7.66 (m, 1H),





7.61 (d, J = 8.1 Hz,





1H), 7.41 (d, J = 6.0 Hz,





1H), 7.03 (dd, J = 15.6,





9.2 Hz, 1H),





6.79 (d, J = 15.9 Hz, 1H),





4.93-4.86 (m, 1H),





4.50-4.45 (m, 1H),





4.00-3.85 (m, 2H),





1.33 (d, J = 7.2 Hz, 3H)


F23

609.00 ([M + H]+)
7.66 (d, J = 8.4 Hz,
3291, 1645,





1H), 7.43 (s, 1H),
1165, 749





7.40 (s, 2H), 7.34 (d, J = 7.6 Hz,





1H), 6.79 (s, 1H),





6.73 (s, 1H), 6.56 (d, J = 16.4 Hz,





1H),





6.43 (dd, J = 16.4, 8.0 Hz,





1H), 4.64-4.60 (m, 1H),





4.13-4.06 (m, 1H),





4.00-3.85 (m, 2H),





2.09 (m, 1H), 1.87-1.78 (m,





2H), 1.37 (t, J = 7.2 Hz,





3H)


F23A

608.99 ([M + H]+)
(400 MHz, DMSO-d6)
3292, 1646,





δ 8.63 (t, J = 6.4 Hz,
1165, 808





1H), 8.59 (d, J = 8.0 Hz,





1H), 7.91 (s, 2H),





7.77 (s, 1H), 7.56 (d, J = 8.0 Hz,





1H), 7.42 (d,





J = 8.0 Hz, 1H),





7.00 (dd, J = 15.6, 9.2 Hz,





1H), 6.78 (d, J = 15.6 Hz,





1H),





4.86-4.81 (m, 1H),





4.42-4.37 (m, 1H),





4.05-3.84 (m, 2H),





1.75-1.61 (m, 2H), 0.92 (t, J = 7.2 Hz,





3H)


F24

622.97 ([M + H]+)
(300 MHz, DMSO-d6)
3421, 1646,





δ 8.65 (d, J = 7.5 Hz,
1168





1H), 8.56 (bs, 1H),





7.92-7.85 (m, 3H),





7.76-7.73 (m, 1H),





7.61 (d, J = 7.8 Hz, 1H),





7.42 (d, J = 7.8 Hz,





1H), 7.04 (dd, J = 15.6,





9.0 Hz, 1H), 6.08 (d, J = 15.9 Hz,





1H),





4.98-4.92 (m, 1H),





4.50-4.46 (m, 1H), 4.00-3.88 (m,





2H), 1.31 (d, J = 7.2 Hz,





3H)


F25

594.94 ([M + H]+)
(300 MHz, DMSO-d6)
3299, 1687,





δ 8.66 (d, J = 7.2 Hz,
1164, 808





1H), 8.57 (t, J = 6.0 Hz,





1H), 7.91 (s, 2H),





7.77 (s, 1H), 7.57 (d, J = 6.9 Hz,





1H), 7.46 (d, J = 7.8 Hz,





1H), 7.02 (dd, J = 15.6,





9.0 Hz, 1H),





6.78 (d, J = 15.6 Hz,





1H), 4.87-4.80 (m, 1H),





4.51-4.47 (m, 1H),





4.04-3.88 (m, 2H),





1.31 (d, J = 7.2 Hz, 3H)


F26

588.96 ([M − H]−)
(300 MHz, DMSO-d6)
3429, 1645,





δ 10.54 (bs, 1H),
1165, 750





8.53 (d, J = 6.9 Hz, 1H),





7.89 (s, 2H),





7.45-7.38 (m, 3H), 6.88 (dd, J = 15.9,





8.4 Hz, 1H),





6.75 (d, J = 15.9 Hz, 1H),





4.87-4.79 (m, 2H),





4.67-4.65 (m, 1H),





4.53-4.50 (m, 1H),





2.33 (s, 3H), 1.37 (d, J = 6.9 Hz,





3H)


F27

655.27 ([M + H]+)
(300 MHz, DMSO-d6)
3422, 1657,





δ 10.52 (bs, 1H),
1161, 806,





8.74 (d, J = 5.7 Hz, 1H),
557





7.93-7.91 (m, 3H),





7.62 (d, J = 8.7 Hz, 1H),





7.48 (d, J = 7.8 Hz,





1H), 6.98 (dd, J = 15.0,





6.3 Hz, 1H), 6.77 (d, J = 15.6 Hz,





1H),





4.88-4.80 (m, 2H),





4.52-4.43 (m, 2H), 1.37 (d, J = 6.9 Hz,





3H)


F28

644.94 ([M + H]+)
(300 MHz, DMSO-d6)
3257, 1663,





δ 10.57 (bs, 1H),
1170, 809,





8.85 (d, J = 7.5 Hz, 1H),
552





7.99-7.70 (m, 4H),





7.65 (d, J = 8.1 Hz, 1H),





7.07 (dd, J = 15.9, 6.9 Hz,





1H), 6.89 (d, J = 15.6 Hz,





1H),





4.88-4.84 (m, 2H), 4.67-4.50 (m,





2H), 1.36 (d, J = 6.9 Hz,





3H)


F29

602.94 ([M − H]−)
(300 MHz, DMSO-d6)
3420, 1645,





δ 9.87 (bs, 1H),
1164, 750





8.40 (bs, 1H), 7.89 (s, 2H),





7.54 (d, J = 8.1 Hz,





1H), 7.45 (s, 1H),





7.41 (d, J = 7.8 Hz, 1H),





6.88 (dd, J = 15.9, 8.7 Hz,





1H), 6.75 (d, J = 15.3 Hz,





1H),





4.85-4.79 (m, 1H), 4.55-4.50 (m,





2H), 2.32 (s, 3H),





1.60 (s, 6H)


F30

611.0 ([M + H]+)
(300 MHz, DMSO-d6)
3432, 1651,





δ 10.65 (bs, 1H),
1259, 750





8.75 (d, J = 6.9 Hz, 1H),





7.90 (s, 2H), 7.78 (s,





1H), 7.58-7.49 (m, 2H),





6.98 (dd, J = 14.7 Hz,





8.0 Hz, 1H), 6.78 (d, J = 15.3 Hz,





1H),





4.89-4.84 (m, 2H),





4.78-4.60 (m, 1H), 4.59-4.49 (m,





1H), 1.37 (d, J = 6.9 Hz,





3H)


F31

618.87 ([M − H]−)
(300 MHz, DMSO-d6)
3436, 1261,





δ 10.14 (s, 1H),
750





9.72 (broad s, 1H), 7.88 (s,





2H), 7.40-7.34 (m, 2H),





7.24 (d, J = 7.8 Hz,





1H), 6.81 (dd, J = 16.0,





8.0 Hz, 1H) 6.69 (d, J = 16.0 Hz,





1H),





4.84-4.78 (m, 1H), 4.55-4.50 (m,





2H), 2.29 (s, 3H),





1.76 (s, 6H)





a1H NMR spectral data were acquired using a 400 MHz instrument in CDCl3 except where noted. HRMS data are noted observed value (theoretical value).













TABLE 2B







Analytical Data for Compounds in Table 1B.











Compound
mp


IR (cm−1);


Number
(° C.)
ESIMS
1H NMR (δ)a
19F NMR (δ)





P1

590.91 ([M + H]+)
(400 MHz, DMSO-d6) δ
3327, 1703,





8.69 (t, J = 5.6 Hz, 1H),
1164, 595





8.56 (t, J = 6.4 Hz, 1H),





7.93-7.88 (m, 3H),





7.77-7.75 (m, 1H),





7.70-7.66 (m, 1H), 7.62-7.60 (m,





1H), 7.45 (d, J = 8.0 Hz,





1H), 7.03 (dd, J = 15.6,





8.8 Hz, 1H),





6.78 (d, J = 15.6 Hz, 1H),





4.92-4.87 (m, 1H),





3.97-3.90 (m, 4H)


P2

581.91 ([M − H]−)
7.63-7.62 (m, 1H),
3280, 2243,





7.58 (d, J = 8.4 Hz, 1H),
1637, 1166





7.39-7.37 (m, 1H),





7.12 (d, J = 8.0 Hz, 2H),





6.78 (t, J = 4.8 Hz, 1H),





6.65 (bs, 1H), 6.59 (d, J = 16.0 Hz,





1H), 6.39 (dd,





J = 15.6, 7.6 Hz, 1H),





4.24-4.20 (m, 3H),





4.00-3.92 (m, 2H)


P12

577.07 ([M + H]+)
(400 MHz, DMSO-d6) δ
3311, 1646,





8.61-8.54 (m, 2H),
1164, 714





7.86 (d, J = 6.4 Hz, 2H),





7.53 (d, J = 8.0 Hz, 1H),





7.45-7.42 (m, 2H),





6.95 (dd, J = 15.6, 9.6 Hz,





1H), 6.80 (d, J = 15.6 Hz,





1H), 4.86-4.76 (m,





1H), 3.98-3.89 (m, 4H),





2.43 (s, 3H)


P14

638.80 ([M − H]−)
(300 MHz, DMSO-d6) δ
3435, 1166,





10.55 (t, J = 6.0 Hz,
749, 597





1H), 10.53 (t, J = 5.2 Hz,





1H), 7.90 (s, 1H),





7.87 (d, J = 8.8 Hz, 2H)





7.59-7.56 (m, 1H),





7.37-7.35 (m, 1H), 6.98 (dd, J = 15.6,





9.0 Hz, 1H),





6.76 (d, J = 15.9 Hz,





1H), 4.84-4.77 (m, 1H),





4.70-4.58 (m, 4H)


P15

590.8 ([M − H]−)
(400 MHz, DMSO-d6) δ
3243, 2923,





10.62 (t, J = 6.0 Hz,
1106, 614





1H), 10.54 (t, J = 5.2 Hz,





1H), 7.89 (s, 2H),





7.42 (s, 1H),





7.39-7.37 (m, 1H), 7.24 (d, J = 7.6 Hz,





1H), 6.84 (dd, J = 15.6,





8.8 Hz, 1H),





6.74 (d, J = 15.6, 1H),





4.84-4.80 (m, 1H), 4.71 (d, J = 6.0 Hz,





2H),





4.65-4.56 (m, 2H), 2.35 (s, 3H)


P82

590.9 ([M + H]+)
(300 MHz, DMSO-d6) δ
3298, 1643,





8.65 (d, J = 7.2 Hz,
1162





1H), 8.56 (t, J = 6.6 Hz,





1H), 7.88 (s, 1H),





7.59-7.56 (m, 2H),





7.47-7.40 (m, 2H),





6.90-6.88 (m, 2H),





4.97-4.94 (m, 1H), 4.50-4.46 (m,





1H), 4.00-3.88 (m,





2H), 1.31 (d, J = 7.2 Hz,





3H)


P84
82-85
581.1 ([M + H]+)
(300 MHz, DMSO-d6) δ





8.74 (d, J = 7.2 Hz, 1H),





8.59 (t, J = 6.6 Hz, 1H),





7.96 (s, 1H), 7.89 (d, J = 7.5 Hz,





1H),





7.61-7.44 (m, 3H) 6.99 (m, 2H),





4.98-4.95 (m, 1H),





4.51-4.47 (m, 1H),





3.99-3.88 (m, 2H),





1.29 (d, J = 6.8 Hz, 3H)


P156

639.0 ([M + H]+)
(400 MHz, DMSO-d6) δ
3436, 2924,





8.66 (d, J = 8.0 Hz, 1H),
1662, 1162,





8.56 (t, J = 5.6 Hz, 1H),
750





7.95-7.93 (m, 2H),





7.60 (d, J = 7.6 Hz, 1H),





7.42 (d, J = 8.0 Hz, 1H),





7.03 (dd, J = 15.6, 8.8 Hz,





1H), 6.94 (d, J = 15.6 Hz,





1H),





5.09-5.04 (m, 1H),





4.53-4.43 (m, 1H),





4.02-3.86 (m, 2H), 1.31 (t, J = 6.8 Hz,





3H)


P226

620.95 ([M + H]+)
(300 MHz, DMSO-d6) δ
3413, 1668,





8.65 (d, J = 7.5 Hz 1H),
1161





8.57 (t, J = 6.3 Hz, 1H),





7.90 (s, 1H),





7.60-7.55 (m, 4H), 7.41 (d, J = 7.8 Hz,





2H), 6.99 (dd, J = 15.6,





9.0 Hz, 1H),





6.78 (d, J = 15.9 Hz, 1H),





4.85-4.79 (m, 1H),





4.50-4.43 (m, 1H),





4.00-3.85 (m, 2H), 1.33 (d, J = 7.8 Hz,





3H)


P228

610.94 ([M + H]+)
(300 MHz, DMSO-d6) δ
3413, 1668,





8.74 (d, J = 7.5 Hz, 1H),
1161, 564





8.61 (t, J = 6.6 Hz, 1H),





7.96 (s, 1H), 7.91 (d, J = 8.1 Hz,





1H),





7.63-7.53 (m, 4H), 7.41 (d, J = 7.5 Hz,





1H), 7.08 (dd, J = 15.6,





8.7 Hz, 1H),





6.89 (d, J = 15.6 Hz, 1H),





4.84-4.81 (m, 1H),





4.51-4.43 (m, 1H),





3.99-3.85 (m, 2H),





1.29 (d, J = 7.5 Hz, 3H)


P298

634.8 ([M + H]+)
(400 MHz, DMSO-d6) δ
3307, 2925,





8.65 (d, J = 7.6 Hz, 1H),
1652, 1164





8.55 (t, J = 6.4 Hz, 1H),





7.92-7.91 (d, J = 1.6 Hz,





1H), 7.67 (s, 1H),





7.62-7.58 (m, 2H),





7.54 (d, J = 9.6 Hz, 1H)





7.41 (d, J = 8.0 Hz, 1H),





6.97 (dd, J = 15.6, 9.2 Hz,





1H), 6.77 (d, J = 15.6 Hz,





1H),





4.82-4.77 (m, 1H),





4.50-4.46 (m, 1H),





4.00-3.82 (m, 2H), 1.31 (t, J = 7.2 Hz,





3H)


P300

623.2 ([M + H]+)
(400 MHz, DMSO-d6) δ
3296, 1652,





8.74 (d, J = 7.6 Hz, 1H),
1167





8.60 (d, J = 16.0 Hz,





1H), 7.97 (s, 1H),





7.90 (d, J = 8.0 Hz, 1H),





7.68 (s, 1H), 7.62-7.59 (m,





1H), 7.56-7.53 (m,





2H), 7.06 (dd, J = 15.6,





9.2 Hz, 1H), 6.88 (d, J = 15.6 Hz,





1H),





4.84-4.80 (m, 1H),





4.51-4.47 (m, 1H),





4.03-3.85 (m, 2H), 1.29 (d, J = 7.2 Hz,





3H)


P442

584.87 ([M + H]+)
(400 MHz, DMSO-d6) δ
3410, 1692,





8.64 (d, J = 7.2 Hz, 1H),
1163, 769,





8.57 (t, J = 12.8 Hz,
565





1H), 7.87 (d, J = 1.2 Hz,





1H), 7.58-7.52 (m,





2H), 7.48 (d, J = 8.4 Hz,





1H), 7.41-7.37 (m,





2H), 6.90 (dd, J = 16.0,





8.8 Hz, 1H), 6.74 (d, J = 15.6 Hz,





1H),





4.68-4.63 (m, 1H),





4.49-4.46 (m, 1H),





3.99-3.86 (m, 2H), 2.35 (s,





3H), 1.28 (d, J = 7.2 Hz,





3H)


P444

574.98 ([M + H]+)
(400 MHz, DMSO-d6) δ
3292, 1661,





8.73 (d, J = 8.0 Hz, 1H),
1158, 741





8.60 (t, J = 6.0 Hz, 1H),





7.92 (s, 1H), 7.88 (d, J = 8.4 Hz,





1H),





7.55-7.53 (m, 2H), 7.48 (d, J = 8.4 Hz,





1H), 7.40 (d, J = 8.4 Hz,





1H), 6.98 (dd, J = 15.6,





8.8 Hz, 1H),





6.86 (d, J = 15.6 Hz, 1H),





4.70-4.66 (m, 1H),





4.50-4.47 (m, 1H),





3.99-3.82 (m, 2H),





2.35 (s, 3H), 1.27 (d, J = 7.2 Hz,





3H)


P514

583.0 ([M + H]+)
(300 MHz, DMSO-d6) δ
3276, 1638,





8.64 (d, J = 7.2 Hz, 1H),
1167, 598





8.57 (t, J = 6.3 Hz, 1H),





7.86 (s,1H), 7.58 (d, J = 7.5 Hz,





1H), 7.41 (d, J = 8.1 Hz,





1H), 7.26 (d, J = 6.6 Hz,





2H), 6.88 (dd, J = 15.9,





8.4 Hz, 1H),





6.73 (d, J = 15.9 Hz,





1H), 4.58-4.46 (m,





2H), 4.00-3.85 (m, 2H),





2.24 (s, 6H), 1.31 (d,





J = 7.5 Hz, 3H)


P516

573.37 ([M + H]+)
(300 MHz, DMSO-d6) δ
3299, 1654,





8.73 (d, J = 7.8 Hz, 1H),
1165





8.61 (t, J = 6.3 Hz, 1H),





7.88 (d, J = 8.4 Hz, 2H),





7.55 (d, J = 8.1 Hz, 1H),





7.27 (d, J = 6.9 Hz, 2H),





6.98 (dd, J = 15.6, 8.4 Hz,





1H), 6.85 (d, J = 15.6 Hz,





1H),





4.57-4.46 (m, 2H),





3.99-3.85 (m, 2H), 2.24 (s,





6H), 1.29 (d, J = 7.2 Hz,





3H)


P568

692.88 ([M + H]+)
(300 MHz, DMSO-d6) δ
3306, 1646,





8.65 (d, J = 7.8 Hz, 1H),
1164





8.55 (t, J = 7.8 Hz, 1H),





7.98 (s, 1H), 7.90 (s,





1H), 7.85 (d, J = 8.7 Hz,





1H), 7.60-7.57 (m,





1H), 7.51-7.48 (m, 1H),





7.41-7.39 (m, 1H),





6.96 (dd, J = 15.6, 8.7 Hz,





1H), 6.76 (d, J = 15.9 Hz,





1H),





4.81-4.72 (m, 1H),





4.50-4.46 (m, 1H),





4.01-3.82 (m, 2H), 1.31 (d, J = 6.9 Hz,





3H)


P586

646.9 ([M − H]−)
7.64 (s, 1H),
3384, 1647,





7.56-7.54 (m, 2H), 7.43-7.39 (m,
1164, 749,





2H), 7.33 (s, 1H),
566





6.81 (bs, 1H), 6.57 (d, J = 16.0 Hz,





1H), 6.50 (d, J = 8.0 Hz,





1H), 6.45 (dd,





J = 16.0, 7.6 Hz, 1H),





4.75-4.72 (m, 1H),





4.14-4.10 (m, 1H),





4.00-3.90 (m, 2H),





1.30 (d, J = 7.2 Hz, 3H)


P588

638.84 ([M + H]+)
(300 MHz, CDCl3) δ
3304, 2928,





7.69 (s, 1H),
1650, 1165,





7.62-7.59 (m, 1H), 7.55-7.49 (m,
673, 558





2H), 7.42 (s, 1H),





7.32 (s, 1H), 6.88 (bs, 1H),





6.65 (d, J = 16.2 Hz,





1H), 6.49 (dd, J = 16.2,





8.1 Hz, 1H), 6.34 (d, J = 7.2 Hz,





1H),





4.76-4.71 (m, 1H), 4.15-4.12 (m,





1H), 3.96-3.89 (m,





2H), 1.49 (d, J = 7.3 Hz,





3H)


P660

682.8 ([M + H]+)
(400 MHz, DMSO-d6) δ
3310, 1650,





8.74 (d, J = 8.0 Hz, 1H),
1166, 558





8.60 (t, J = 8.8 Hz, 1H),





7.99-7.96 (m, 2H),





7.90 (d, J = 8.3 Hz, 1H),





7.85 (d, J = 8.3 Hz, 1H),





7.55-7.50 (m, 2H),





7.04 (dd, J = 15.6, 8.8 Hz,





1H), 6.86 (d, J = 16.0 Hz,





1H), 4.83-4.78 (m,





1H), 4.51-4.47 (m,





1H), 3.99-3.86 (m,





2H), 1.29 (d, J = 5.1 Hz,





3H)


P730

615.85 ([M + H]+)
(300 MHz, DMSO-d6) δ
3299, 1651,





8.67 (d, J = 7.8 Hz, 1H),
1166, 739





8.55 (t, J = 6.6 Hz, 1H),





8.31 (s, 1H),





7.90-7.86 (m, 3H), 7.60 (d, J = 9.2 Hz,





1H), 7.42 (d, J = 8.1 Hz,





1H), 6.98 (dd, J = 15.6,





8.7 Hz, 1H),





6.79 (d, J = 15.6 Hz, 1H),





4.96-4.95 (m, 1H),





4.50-4.45 (m, 1H),





3.96-3.88 (m, 2H),





1.31 (d, J = 9.3 Hz, 3H)


P732

605.96 ([M + H]+)
(300 MHz, CDCl3) δ
3297, 1651,





7.91 (s, 1H), 7.69 (s,
1167, 749





1H), 7.64-7.50 (m,





4H), 6.71 (bs, 1H),





6.67 (d, J = 16.2 Hz, 1H),





6.52 (dd, J = 15.9, 7.8 Hz,





1H), 6.30 (d, J = 6.9 Hz,





1H), 4.73-4.69 (m,





1H), 4.30-4.24 (m,





1H), 3.96-3.91 (m,





2H), 1.49 (d, J = 7.2 Hz,





3H)


P802

578.1 ([M − H]−)
(300 MHz, DMSO-d6)
3307, 2927,





δ 8.65 (d, J = 7.2 Hz,
2238, 1659,





1H), 8.56 (t, J = 6.3 Hz,
1166





1H), 8.20-8.18 (m,





1H), 8.00-7.90 (m,





2H), 7.66-7.54 (m,





2H), 7.42 (d, J = 8.1 Hz,





1H), 6.99 (dd, J = 15.9,





9.3 Hz, 1H),





6.77 (d, J = 15.9 Hz, 1H),





4.88-4.82 (m, 1H),





4.51-4.46 (m, 1H),





4.00-3.88 (m, 2H),





1.29 (d, J = 7.2 Hz, 3H)


P804

570.3 ([M + H]+)
(300 MHz, DMSO-d6)
3301, 3078,





δ 8.74 (d, J = 7.8 Hz,
2239, 1657,





1H), 8.59 (t, J = 6.6 Hz,
1167





1H), 8.21-8.19 (m,





1H), 8.01-7.96 (m,





2H), 7.90 (d, J = 8.1 Hz,





1H), 7.66-7.60 (m,





1H), 7.56 (d, J = 8.1 Hz,





1H), 7.08 (dd, J = 15.9,





8.7 Hz, 1H),





6.88 (d, J = 15.6 Hz, 1H),





4.91-4.85 (m, 1H),





4.52-4.47 (m, 1H),





3.99-3.88 (m, 2H),





1.29 (d, J = 6.9 Hz, 3H)


P1090

569.89 ([M + H]+)
(300 MHz, DMSO-d6) δ
3277, 1698,





8.64 (d, J = 7.5 Hz, 1H),
1167, 518





8.55 (t, J = 6.3 Hz, 1H),





7.86 (s, 1H), 7.58 (d, J = 7.2 Hz,





1H), 7.47 (d, J = 6.9 Hz,





1H),





7.41-7.36 (m, 3H), 7.21-7.15 (m,





1H), 6.91 (dd, J = 15.6,





8.7 Hz, 1H), 6.74 (d, J = 15.9 Hz,





1H),





4.66-4.60 (m, 1H),





4.50-4.45 (m, 1H), 4.03-3.85 (m,





2H), 2.26 (s, 3H),





1.31 (d, J = 7.2 Hz, 3H)


P1092

559.05 ([M + H]+)
(300 MHz, DMSO-d6) δ
3437, 1643,





8.74 (d, J = 7.8 Hz, 1H),
1165





8.59 (t, J = 6.3 Hz, 1H),





7.92 (s, 1H), 7.89 (d, J = 8.1 Hz,





1H), 7.56 (d, J = 8.1 Hz,





1H), 7.48 (d, J = 7.2 Hz,





1H),





7.42-7.38 (m, 1H), 7.19 (t, J = 9.3 Hz,





1H), 7.00 (dd, J = 15.9,





8.7 Hz, 1H),





6.85 (d, J = 15.9 Hz, 1H),





4.69-4.62 (m, 1H),





4.51-4.47 (m, 1H),





4.02-3.85 (m, 2H),





2.26 (s, 3H), 1.29 (d, J = 7.2 Hz,





3H)


P1197

576.83 ([M + H]+)
(300 MHz, CDCl3) δ
3311, 1655,





7.62-7.56 (m, 2H),
1166





7.40-7.37 (m, 1H),





7.05-7.00 (m, 2H), 6.72 (bs, 1H),





6.56 (bs, 1H), 6.51 (d, J = 16.2 Hz,





1H),





6.52 (dd, J = 15.9, 7.5 Hz,





1H), 4.21 (d, J = 5.4 Hz,





2H), 4.13-4.08 (m, 1H),





4.02-3.91 (m, 2H)


P1269

659.07 ([M + H]+)
(300 MHz, CDCl3) δ
3317, 1706,





7.91 (s, 1H), 7.83 (s,
1175, 559





2H), 7.64-7.56 (m, 2H),





7.42-7.39 (m, 1H),





6.74 (bs, 1H), 6.62 (bs, 1H),





6.61 (d, J = 15.9 Hz,





1H), 6.50 (dd, J = 15.7,





7.8 Hz, 1H),





4.35-4.30 (m, 1H), 4.21 (d, J = 6.0 Hz,





2H), 4.02-3.90 (m,





2H)


P1340

607.00 ([M − H]−)
(300 MHz, DMSO-d6) δ
3411, 1652,





8.68 (t, J = 5.7 Hz, 1H),
1166





8.56 (t, J = 6.3 Hz, 1H),





7.93 (s, 1H),





7.87-7.83 (m, 2H), 7.76-7.75 (m,





1H), 7.62-7.55 (m, 1H),





7.45 (d, J = 7.8 Hz, 1H),





7.05 (dd, J = 15.6, 9.0 Hz,





1H), 6.88 (d, J = 15.3 Hz,





1H),





4.99-4.92 (m, 1H), 4.01-3.90 (m,





4H)


P1411

624.92 ([M + H]+)
(300 MHz, CDCl3) δ
3098, 1721,





7.64 (s, 1H),
1214, 723,





7.58-7.55 (m, 3H), 7.51 (s, 1H),
513





7.41-7.38 (m, 1H),





6.77 (bs, 1H), 6.72 (bs, 1H),





6.59 (d, J = 15.9 Hz,





1H), 6.48 (dd, J = 15.9,





7.5 Hz, 1H),





4.24-4.19 (m, 4H), 4.01-3.90 (m,





1H)


P1483

608.78 ([M + H]+)
(300 MHz, CDCl3) δ
3300, 1657,





7.62-7.54 (m, 3H),
1164, 560





7.39 (d, J = 8.1 Hz, 1H),





7.29-7.24 (m, 1H),





6.84-6.82 (m, 1H), 6.56 (d, J = 15.6 Hz,





1H),





6.49 (dd, J = 15.6, 6.6 Hz,





1H), 4.23-4.19 (m, 2H),





4.01-3.93 (m, 3H)


P1556

614.84 ([M + H]+)
7.70 (s, 1H),
3369, 1719,





7.63-7.61 (m, 1H), 7.56-7.51 (m,
1164, 807.





1H), 7.41 (s, 2H),





6.65 (d, J = 15.6 Hz, 1H),





6.60 (bs, 2H), 6.50 (dd,





J = 15.2, 6.8 Hz, 1H),





4.19-4.13 (m, 3H),





3.98-3.94 (m, 2H)


P1558

595.00 ([M − H]−)
(300 MHz, CDCl3) δ
3351, 1660,





8.89 (bs, 1H),
1161, 700





7.72-7.69 (d, J = 8.1 Hz, 1H),





7.45-7.35 (m, 4H),





7.25-7.19 (m, 1H), 6.58 (d, J = 15.9 Hz,





1H),





6.45 (dd, J = 15.9, 7.8 Hz,





1H), 4.57 (d, J = 5.7 Hz,





2H), 4.49-4.38 (m, 2H),





4.16-4.03 (m, 1H)


P1559

628.95 ([M − H]−)
(300 MHz, DMSO-d6) δ
3398, 1664,





10.45 (t, J = 6.4 Hz,
1163, 808





1H), 8.97 (t, J = 6.0 Hz,





1H), 8.02-7.92 (m, 4H),





7.77 (d, J = 7.5 Hz, 1H),





7.10 (dd, J = 15.6, 9.0 Hz,





1H), 6.90 (d, J = 15.6 Hz,





1H),





4.90-4.82 (m, 1H), 4.63-4.58 (m,





2H), 4.23 (d, J = 6.0 Hz,





2H)


P1560

574.88 ([M − H]−)
(400 MHz, DMSO-d6) δ
3246, 1646,





10.38 (t, J = 6.0 Hz,
1161, 808





1H), 8.65 (t, J = 5.6 Hz,





1H), 7.88 (s, 2H),





7.50-7.42 (m, 3H), 6.88 (dd, J = 15.6,





8.8 Hz, 1H),





6.75 (d, J = 15.6 Hz,





1H), 4.85-4.81 (m, 1H),





4.63-4.54 (m, 2H),





4.24 (d, J = 6.2 Hz, 2H),





2.36 (s, 3H)


P1564

576.6 ([M + H]+)
(400 MHz, DMSO-d6) δ
3351, 1684,





10.48 (t, J = 6.0 Hz,
1163, 808





1H), 8.74 (t, J = 6.2 Hz,





1H), 7.89 (s, 2H),





7.41-7.36 (m, 2H), 7.19 (d, J = 8.0 Hz,





1H), 6.84 (dd,





J = 15.6, 8.8 Hz, 1H),





6.73 (d, J = 15.6 Hz,





1H), 4.84-4.79 (m, 1H),





4.42 (d, J = 6.0 Hz, 2H),





3.98-3.92 (m, 2H),





2.32 (s, 3H)


P1566

597.00 ([M + H]+)
(400 MHz, DMSO-d6) δ
3323, 1654,





8.74 (t, J = 5.6 Hz, 1H),
1115, 808





8.30 (t, J = 6.0 Hz, 1H),





8.03-7.84 (m, 4H),





7.61 (d, J = 8.4 Hz, 1H),





7.09 (dd, J = 15.6, 8.8 Hz,





1H), 6.89 (d, J = 16.4 Hz,





1H),





4.88-4.81 (m, 1H), 3.89 (d, J = 5.6 Hz,





2H), 3.59-3.48 (m,





3H)


P1589

638.9 ([M + H]+)
(300 MHz, DMSO-d6) δ
3412, 1657,





8.63 (t, J = 5.7 Hz, 1H),
1169, 749,





8.50 (d, J = 9.0 Hz, 1H),
565





7.93-7.91 (m, 3H),





7.62-7.60 (m, 1H), 7.42 (d, J = 7.8 Hz,





1H), 7.01 (dd,





J = 15.6, 9.6 Hz, 1H),





6.77 (d, J = 15.6 Hz,





1H), 4.88-4.80 (m, 1H),





4.66-4.60 (m, 1H),





4.00-3.97 (m, 1H),





3.87-3.80 (m, 1H), 1.27 (d, J = 6.9 Hz,





3H)


P1591

628.95 ([M + H]+)
(300 MHz, DMSO-d6) δ
3436, 1667,





8.74 (t, J = 6.0 Hz, 1H),
1261, 749





8.51 (d, J = 8.7 Hz, 1H),





7.99 (s, 1H),





7.92-7.90 (m, 3H), 7.58 (d, J = 8.1 Hz,





1H), 7.10 (dd, J = 15.6,





8.7 Hz, 1H),





6.89 (d, J = 15.9 Hz, 1H),





4.89-4.86 (m, 1H),





4.66-4.58 (m, 1H),





4.00-3.92 (m, 1H), 3.88-3.80 (m,





1H), 1.27 (d, J = 7.2 Hz,





3H)


P1592

574.98 ([M + H]+)
(300 MHz, DMSO-d6) δ
3418, 1651,





8.51 (d, J = 8.7 Hz, 1H),
1163, 748





8.41 (t, J = 6.0 Hz, 1H),





7.89 (s, 2H),





7.45-7.35 (m, 3H), 6.83 (dd, J = 15.6,





8.5 Hz, 1H),





6.75 (d, J = 15.6 Hz, 1H),





4.86-4.79 (m, 1H),





4.65-4.60 (m, 1H),





3.98-3.91 (m, 1H), 3.85-3.78 (m,





1H), 2.36 (s, 3H),





1.26 (d, J = 6.9 Hz, 3H)


P1599

689.9 ([M + H]+)
(300 MHz, DMSO-d6)
3415, 1599,





δ 8.67 (bs, 1H), 8.60 (t,
1162, 748





J = 6.0 Hz, 1H), 7.95 (d,





J = 9.9 Hz, 2H), 7.91 (s,





1H), 7.78 (d, J = 6.6 Hz,





1H), 7.42 (d, J = 7.8 Hz,





1H) 7.12 (dd, J = 15.6,





9.9 Hz, 1H), 6.78 (d, J = 15.3 Hz,





1H),





4.94-4.91 (m, 1H),





4.52-4.45 (m, 1H),





4.00-3.85 (m, 2H), 1.33 (d, J = 6.9 Hz,





3H)


P1601

678.6 ([M + H]+)
(300 MHz, DMSO-d6)
3423, 1646,





δ 8.73 (bs, 1H), 8.59 (t,
1141, 807





J = 6.0 Hz, 1H), 7.95 (d,





J = 9.9 Hz, 2H),





7.88-7.83 (m, 2H), 7.56 (d, J = 7.2 Hz,





1H), 7.12 (dd,





J = 15.6, 10.5 Hz, 1H),





6.78 (d, J = 15.3 Hz,





1H), 4.94-4.91 (m,





1H), 4.51-4.43 (m,





1H), 3.99-3.88 (m,





2H), 1.31 (d, J = 6.9 Hz,





3H)


P1603
113-117
563 ([M + H]+)
7.80-7.72 (m, 2H),
19F NMR





7.48-7.44 (m, 2H),
(376 MHz,





7.42 (s, 2H), 6.92 (t, J = 6.4 Hz,
CDCl3) δ −68.66,





1H), 6.62 (m,
−72.52





1H), 6.42 (dd, J = 15.9,





8.0 Hz, 1H), 4.75 (p, J = 7.1 Hz,





1H), 4.11 (p, J = 8.5 Hz,





1H),





4.07-3.79 (m, 2H), 1.54 (d, J = 7.0 Hz,





3H)


P1611A

621.0 ([M + H]+)
(300 MHz, DMSO-d6) δ
3410, 2925,





8.60 (d, J = 7.8 Hz, 1H),
1645, 1115,





8.28 (t, J = 5.7 Hz, 1H),
748, 561





7.91 (s, 3H),





7.61-7.58 (m, 1H), 7.43 (d, J = 8.1 Hz,





1H), 7.01 (dd, J = 15.6,





9.0 Hz, 1H),





6.77 (d, J = 15.9 Hz, 1H),





4.86-4.79 (m, 1H),





4.49-4.44 (m, 1H),





3.55-3.31 (m, 2H),





1.30 (d, J = 6.9 Hz, 3H)


P1613A

611.1 ([M + H]+)
(300 MHz, DMSO-d6) δ
3297, 1651,





8.70 (d, J = 7.8 Hz, 1H),
1115, 808





8.31 (t, J = 5.7 Hz, 1H),





7.98 (s, 1H),





7.92-7.88 (m, 3H), 7.57-7.55 (m,





1H),), 7.09 (dd, J = 15.3,





9.0 Hz, 1H),





6.89 (d, J = 15.9 Hz, 1H),





4.89-4.82 (m, 1H),





4.52-4.43 (m, 1H),





3.57-3.47 (m, 2H),





1.29 (d, J = 7.5 Hz, 3H)


P1616

602.8 ([M + H]+)
(300 MHz, DMSO-d6) δ
3305, 1650,





8.64 (d, J = 7.5 Hz, 1H),
1169, 749,





8.11 (t, J = 5.4 Hz, 1H),
559





7.91 (s, 3H),





7.60-7.58 (m, 1H), 7.43 (d, J = 8.2 Hz,





1H), 7.00 (dd, J = 15.6,





9.0 Hz, 1H),





6.77 (d, J = 15.9 Hz, 1H),





4.86-4.53 (m, 1H),





4.51-4.42 (m, 2H),





4.35 (t, J = 5.1 Hz, 1H),





3.45-3.31 (m, 2H),





1.31 (d, J = 7.2 Hz, 3H)


P1616A

602.8 ([M + H]+)
(400 MHz, DMSO-d6) δ
3407, 1651,





8.53 (d, J = 7.60 Hz,
1169, 744,





1H), 8.08 (t, J = 6.0 Hz,
559





1H), 7.91-7.90 (m 3H),





7.59 (d, J = 7.6 Hz, 1H),





7.43 (d, J = 8.0 Hz, 1H),





6.98 (dd, J = 16.0, 9.2 Hz,





1H), 6.77 (d, J = 16.0 Hz,





1H),





4.84-4.80 (m, 1H),





4.50-4.36 (m, 3H),





3.44-3.24 (m, 2H), 1.30 (d, J = 7.2 Hz,





3H)


P1618A

593.1 ([M + H]+)
(300 MHz, DMSO-d6) δ
3411, 1651,





8.64 (d, J = 7.8 Hz, 1H),
1115, 809





8.17 (t, J = 5.4 Hz, 1H),





8.03-7.87 (m, 3H),





7.60 (d, J = 7.8 Hz, 1H),





7.09 (dd, J = 15.9, 9.0 Hz,





1H), 6.89 (d, J = 15.9 Hz,





1H),





4.89-4.53 (m, 1H),





4.53-4.42 (m, 2H), 4.35 (t, J = 5.1 Hz,





1H),





3.44-3.42 (m, 2H), 1.28 (d, J = 6.9 Hz,





3H)


P1621

585.0 ([M + H]+)
(300 MHz, DMSO-d6) δ
3411, 1649,





8.50 (bs, 1H), 7.91 (s,
1168, 806,





3H), 7.83-7.81 (m,
559





1H), 7.60 (d, J = 8.1 Hz,





1H), 7.43. (d, J = 8.1 Hz,





1H), 7.00 (dd, J = 15.9,





9.9 Hz, 1H),





6.77 (d, J = 15.9 Hz, 1H),





4.86-4.80 (m, 1H),





4.40-4.36 (m, 1H),





3.14-3.06 (m, 2H),





1.28 (d, J = 6.9 Hz, 3H),





1.03 (t, J = 6.0 Hz, 3H)


P1623

575.1 ([M + H]+)
(300 MHz, DMSO-d6)
3412, 1645,





δ 8.59 (bs, 1H), 7.97 (s,
1115, 749





1H), 7.92-7.85 (m,





4H), 7.57 (d, J = 7.8 Hz,





1H), 7.09 (dd, J = 16.2,





9.3 Hz, 1H), 6.88 (d, J = 15.9 Hz,





1H),





4.89-4.82 (m, 1H),





4.43-4.36 (m, 1H),





3.12-3.05 (m, 2H), 1.26 (d, J = 7.2 Hz,





3H), 1.05 (t, J = 7.5 Hz,





3H)


P1624

521.2 ([M + H]+)
(300 MHz, DMSO-d6) δ
3307, 1642,





8.26 (bs, 1H), 7.89 (s,
1114, 749





1H), 7.85-7.81 (m, 2H),





7.47-7.37 (m, 2H),





7.34 (d, J = 7.5 Hz, 1H),





6.88 (dd, J = 15.9, 8.7 Hz,





1H), 6.75 (d, J = 15.9 Hz,





1H),





4.85-4.79 (m, 1H),





4.39-4.34 (m, 1H),





3.13-3.04 (m, 2H), 2.48 (s,





3H), 1.28 (d, J = 7.5 Hz,





3H), 1.04 (t, J = 7.5 Hz,





3H)


P1631A

652.8 ([M + H]+)
(400 MHz, DMSO-d6) δ
3297, 1646,





8.54 (d, J = 7.60 Hz,
1161, 742,





1H), 8.07 (t, J = 5.4 Hz,
555





1H), 7.91-7.90 (m





3H), 7.60 (d, J = 9.2 Hz,





1H), 7.43 (d, J = 8.0 Hz,





1H), 6.98 (dd, J = 16.0,





9.0 Hz, 1H),





6.77 (d, J = 16.0 Hz, 1H),





4.85-4.80 (m, 1H),





4.41-4.37 (m, 1H),





3.40-3.26 (m, 2H),





2.50-2.38 (m, 2H),





1.28 (d, J = 7.6 Hz, 3H)


P1633A

640.7 ([M − H]−)
(300 MHz, DMSO-d6) δ
3299, 1651,





8.66 (d, J = 7.2 Hz, 1H),
1139, 808





8.13 (t, J = 5.4 Hz, 1H),





7.97 (s, 1H),





7.92-7.88 (m, 3H), 7.58 (d, J = 8.2 Hz,





1H), 7.09 (dd, J = 16.3,





9.0 Hz, 1H),





6.89 (d, J = 15.9 Hz, 1H),





4.89-4.82 (m, 1H),





4.42-4.37 (m, 1H),





3.38-3.24 (m, 2H),





2.44-2.36 (m, 2H),





1.27 (d, J = 7.2 Hz, 3H)


P1636
176-184
575 ([M − H]−)
7.76-7.72 (m, 2H),
19F NMR





7.48-7.44 (m, 2H),
(376 MHz,





7.42 (s, 2H), 6.62 (d, J = 15.9 Hz,
CDCl3)





1H), 6.54 (s,
rotomers δ −68.65,





1H), 6.42 (dd, J = 15.9,
−72.57,





7.9 Hz, 1H), 4.89 (s,
−73.24





1H), 4.11 (p, J = 8.7 Hz,





1H), 3.92 (dqd, J = 22.9,





9.0, 6.5 Hz, 2H), 1.71 (s,





6H)


P1638

638.64 ([M + H]+)
(300 MHz, DMSO-d6) δ
3427, 2924,





8.60 (bs, 1H), 8.44 (t, J = 6.0 Hz,
1651, 1162,





1H), 7.90 (s,
680





3H), 7.59 (d, J = 6.9 Hz,





1H), 7.33 (d, J = 7.8 Hz,





1H), 7.00 (dd, J = 16.2,





9.6 Hz, 1H),





6.76 (d, J = 15.3 Hz, 1H),





4.88-4.4.80 (m, 1H),





3.92-3.87 (m, 2H),





3.42-3.40 (m, 2H),





2.50-2.49 (m, 2H)


P1640

628.9 ([M + H]+)
(300 MHz, DMSO-d6) δ
3445, 1644,





8.61 (bs, 1H), 8.53 (t, J = 6.0 Hz,
1163, 749





1H), 7.96 (s,





1H), 7.92-7.86 (m,





3H), 7.47 (d, J = 9.0 Hz,





1H), 7.18 (dd, J = 15.6,





8.1 Hz, 1H), 6.88 (d, J = 15.6 Hz,





1H),





4.91-4.78 (m, 1H), 3.96-3.84 (m,





2H), 3.45-3.38 (m,





2H), 2.50-2.43 (m, 2H)


P1641

574.8 ([M + H]+)
(300 MHz, DMSO-d6) δ
3427, 2926,





8.61 (bs, 1H), 8.27 (t, J = 5.4 Hz,
1645, 1162,





1H), 7.89 (s,
809





2H), 7.47-7.37 (m,





2H), 7.28 (d, J = 8.1 Hz,





1H), 6.88 (dd, J = 15.6,





9.0 Hz, 1H), 6.74 (d, J = 15.9 Hz,





1H),





4.88-4.81 (m, 1H),





3.92-3.86 (m, 2H),





3.45-3.38 (m, 2H),





2.51-2.44 (m, 2H), 2.32 (s,





3H)


P1691

654.8 ([M + H]+)
(300 MHz, DMSO-d6) δ
3301, 1647,





8.64 (d, J = 7.2 Hz, 1H),
1164, 746





8.57 (t, J = 6.3 Hz, 1H),





7.91 (s, 1H), 7.71 (s,





2H), 7.66 (s, 1H),





7.57 (d, J = 8.1 Hz, 1H),





7.41 (d, J = 7.5 Hz, 1H),





7.03 (dd, J = 15.6, 9.6 Hz,





1H), 6.78 (d, J = 15.6 Hz,





1H), 4.91-4.71 (m,





1H), 4.50-4.45 (m,





1H), 4.02-3.82 (m,





2H), 1.30 (d, J = 7.2 Hz,





3H)


P1693

645.1 ([M + H]+)
(300 MHz, DMSO-d6) δ
3309, 1650,





8.73 (d, J = 7.2 Hz, 1H),
1165, 677





8.61 (d, J = 6.3 Hz, 1H),





7.96 (s, 1H),





7.86-7.80 (m, 1H), 7.71 (s, 2H),





7.67 (d, J = 8.1 Hz, 1H),





7.56 (d, J = 7.8 Hz, 1H),





7.00 (dd, J = 15.6, 9.3 Hz,





1H), 6.90 (d, J = 15.9 Hz,





1H),





4.92-4.71 (m, 1H),





4.51-4.49 (m, 1H),





3.99-3.85 (m, 2H), 1.29 (d, J = 7.2 Hz,





3H)


P1696

604.2 ([M + H]+)
(300 MHz, DMSO-d6) δ
3418, 1645,





8.65 (d, J = 7.2 Hz, 1H),
1165, 750,





8.55 (t, J = 6.0 Hz, 1H),
562





7.92 (d, J = 1.5 Hz,





1H), 7.68 (t, J = 3.3 Hz,





3H), 7.60 (d, J = 6.9 Hz,





1H), 7.42 (d, J = 7.8 Hz,





1H), 7.00 (dd, J = 15.3,





8.7 Hz, 1H), 6.76 (d, J = 15.6 Hz,





1H), 4.83 (t, J = 7.2 Hz,





1H), 4.51 (t, J = 7.2 Hz,





1H),





4.01-3.88 (m, 2H), 1.29 (d, J = 7.2 Hz,





3H)


P1698

595.1 ([M + H]+)
(300 MHz, DMSO-d6) δ
3294, 2928,





8.74 (d J = 7.5 Hz, 1H),
1646, 1166,





8.59 (t, J = 6.6 Hz, 1H),
750





7.98 (s, 1H), 7.91 (d, J = 8.4 Hz,





1H),





7.69-7.62 (m, 2H), 7.56 (d, J = 7.5 Hz,





1H), 7.09 (dd,





J = 15.3, 8.7 Hz, 1H),





6.88 (d, J = 15.6 Hz,





1H), 4.83-4.80 (m,





1H), 4.51-4.47 (m,





1H), 3.99-3.86 (m,





2H), 1.29 (d, J = 7.2 Hz,





3H)


P1776

593.2 ([M + H]+)
(400 MHz, DMSO-d6) δ
19F NMR





8.69 (t, J = 6.0 Hz, 1H),
(376 MHz,





8.57 (t, J = 6.4 Hz, 1H),
DMSO-d6) δ −67.98,





7.90 (dd, J = 13.3, 1.8 Hz,
−70.71





2H), 7.72 (d, J = 8.4 Hz,





1H), 7.58 (ddd, J = 18.0,





8.2, 1.8 Hz, 2H),





7.44 (d, J = 7.9 Hz, 1H),





6.94 (dd, J = 15.7, 9.0 Hz,





1H), 6.74 (d, J = 15.7 Hz,





1H), 4.81 (p, J = 9.4 Hz,





1H),





4.02-3.87 (m, 4H)


P1781

513.2 ([M + H]+)
7.85-7.74 (m, 2H),
19F NMR





7.53-7.41 (m, 4H),
(376 MHz,





7.30 (t, J = 6.2 Hz, 1H),
CDCl3) δ −68.78,





7.23 (dd, J = 8.4, 2.0 Hz,
−72.44





1H), 7.19 (t, J = 5.2 Hz,





1H), 6.61 (d, J = 15.9 Hz,





1H), 6.46 (dd,





J = 15.9, 7.8 Hz, 1H),





4.26 (d, J = 5.1 Hz, 2H),





4.21-4.07 (m, 1H),





3.95 (qd, J = 9.1, 6.4 Hz,





2H)


P1806

605.0 ([M + H]+)
(300 MHz, DMSO-d6) δ
3411, 2925,





8.67 (d, J = 7.2 Hz, 1H),
1650, 1163,





8.57 (t, J = 6.3 Hz, 1H),
747





7.91-7.88 (m, 2H),





7.74 (d, J = 8.7 Hz, 1H),





7.64-7.59 (m, 2H),





7.41 (d, J = 8.1 Hz, 1H),





6.98 (dd, J = 15.9, 9.3 Hz,





1H), 6.76 (d, J = 15.9 Hz,





1H),





4.83-4.77 (m, 1H),





4.52-4.43 (m, 1H),





4.05-3.83 (m, 2H), 1.30 (d, J = 7.2 Hz,





3H)


P1808

695.1 ([M + H]+)
(400 MHz, DMSO-d6) δ
3297, 1652,





8.74 (d, J = 7.2 Hz, 1H),
1165, 745





8.59 (s, 1H),





7.96-7.89 (m, 3H), 7.73 (d, J = 8.4 Hz,





1H), 7.55 (t, J = 8.8 Hz,





2H), 7.05 (dd, J = 16.0,





8.8 Hz, 1H),





6.87 (d, J = 16.0 Hz, 1H),





4.85-4.80 (m, 1H),





4.51-4.47 (m, 1H),





3.99-3.88 (m, 2H),





1.28 (d, J = 6.8 Hz, 3H)


P1862

598.89 ([M + H]+)
7.70 (s, 1H),
3324, 1673,





7.62-7.60 (m, 1H), 7.55-7.53 (m,
1164, 772





1H), 7.35 (d, J = 5.6 Hz,





2H), 7.89 (t, J = 6.0 Hz,





1H), 6.67 (t, J = 5.6 Hz,





1H), 6.64 (d, J = 16.0 Hz,





1H), 6.48 (dd, J = 16.4,





8.0 Hz, 1H),





4.23 (d, J = 5.6 Hz, 2H),





4.17-4.08 (m, 1H),





3.97-3.89 (m, 2H)


P1864

622.88 ([M − H]−)
(400 MHz, DMSO-d6) δ
3256, 1657,





10.39 (bs, 1H), 8.85 (t, J = 6.0 Hz,
1166, 749,





1H), 7.94 (s,
591





1H), 7.87 (d, J = 6.4 Hz,





2H), 7.64 (d, J = 8.4 Hz,





1H), 7.58 (d, J = 8.0 Hz,





1H), 7.00 (dd, J = 15.6,





8.8 Hz, 1H), 6.77 (d, J = 15.6 Hz,





1H),





4.81-4.79 (m, 1H), 4.63-4.59 (m,





2H), 4.24 (d, J = 6.0 Hz,





2H)


P1866

614.91 ([M + H]+)
(400 MHz, DMSO-d6) δ
3447, 1655,





10.43 (bs, 1H), 8.96 (t, J = 6.0 Hz,
1167, 816





1H), 8.00 (s,





1H), 7.94 (d, J = 7.6 Hz,





1H), 7.88 (d, J = 6.4 Hz,





2H), 7.76 (d, J = 8.0 Hz,





1H), 7.09 (dd, J = 15.6,





9.2 Hz, 1H), 6.88 (d, J = 16.0 Hz,





1H),





4.86-4.78 (m, 1H), 4.62-4.58 (m,





2H), 4.23 (d, J = 5.6 Hz,





2H)


P1969

678.77 ([M + H]+)
(300 MHz, DMSO-d6) δ
3296, 1697,





8.65 (t, J = 5.4 Hz, 1H),
1164, 596





8.54 (t, J = 6.3 Hz, 1H),





7.90-7.86 (m, 2H),





7.82 (s, 2H), 7.60 (d, J = 7.2 Hz,





1H), 7.43 (d, J = 7.8 Hz,





1H), 6.99 (dd, J = 15.6,





9.0 Hz, 1H),





6.75 (d, J = 15.6 Hz, 1H),





4.83-4.76 (m, 1H),





4.01-3.91 (m, 4H)


P1970

634.87 ([M + H]+)
(300 MHz, DMSO-d6) δ
3299, 1658,





8.68 (t, J = 6.0 Hz, 1H),
1164, 745,





8.57 (t, J = 6.0 Hz, 1H),
543





7.89-7.78 (m, 4H),





7.59-7.56 (m, 1H),





7.49-7.46 (m, 1H),





7.02 (dd, J = 15.9, 8.1 Hz,





1H), 6.78 (d, J = 15.6 Hz,





1H),





4.83-4.76 (m, 1H),





4.01-3.91 (m, 4H)


P1971

668.87 ([M + H]+)
(300 MHz, DMSO-d6) δ
3351, 1705,





8.77 (t, J = 6.0 Hz, 1H),
1165, 551





8.59 (t, J = 6.3 Hz, 1H),





7.99 (s, 1H),





7.93-7.85 (m, 4H), 7.60 (d, J = 8.1 Hz,





1H), 7.10 (dd, J = 15.9,





9.3 Hz, 1H),





6.89 (d, J = 15.9 Hz, 1H),





4.85-4.79 (m, 1H),





3.98-3.90 (m, 4H)


P1972

614.84 ([M + H]+)
(400 MHz, DMSO-d6) δ
3311, 1650,





8.57 (t, J = 6.4 Hz, 1H),
1163, 543





8.47 (t, J = 6.0 Hz, 1H),





7.88-7.80 (m, 3H),





7.45 (s, 1H), 7.43-7.37 (m,





2H), 6.86 (dd, J = 15.6,





8.8 Hz, 1H), 6.74 (d, J = 15.6 Hz,





1H),





4.83-4.74 (m, 1H), 3.98-3.88 (m,





4H), 2.37 (s, 3H)


P2009

692.88 ([M + H]+)
(300 MHz, DMSO-d6) δ
3402, 1659,





8.62 (t, J = 5.7 Hz, 1H),
1165, 560





8.50 (d, J = 8.7 Hz, 1H),





7.93-7.92 (m, 1H),





7.89-7.88 (m, 1H),





7.84 (s, 2H),





7.62-7.59 (m, 1H), 7.42 (d, J = 8.1 Hz,





1H), 7.01 (dd, J = 15.9,





9.2 Hz, 1H),





6.77 (d, J = 15.6 Hz, 1H),





4.82-4.76 (m, 1H),





4.65-4.58 (m, 1H),





4.00-3.92 (m, 1H),





3.87-3.80 (m, 1H), 1.27 (d, J = 6.9 Hz,





3H)


P2010

646.84 ([M − H]−)
(300 MHz, DMSO-d6) δ
3406, 1658,





8.63 (t, J = 6.0 Hz, 1H),
1165, 746,





8.50 (d, J = 8.7 Hz, 1H),
583





7.89-7.88 (m, 1H),





7.84 (s, 2H), 7.78 (s,





1H), 7.59-7.56 (m,





1H), 7.46 (d, J = 7.5 Hz,





1H), 7.00 (dd, J = 15.6,





9.0 Hz, 1H), 6.78 (d, J = 15.3 Hz,





1H),





4.79-4.76 (m, 1H),





4.63-4.60 (m, 1H),





3.95-3.86 (m, 2H), 1.27 (d, J = 7.2 Hz,





3H)


P2011

682.93 ([M + H]+)
(400 MHz, DMSO-d6) δ
3417, 1666,





8.73 (t, J = 5.6 Hz, 1H),
1115, 558





8.50 (d, J = 8.8 Hz, 1H),





7.98 (s, 1H),





7.90-7.89 (m, 2H), 7.85 (s, 2H),





7.57 (d, J = 8.4 Hz, 1H),





7.09 (dd, J = 15.6, 9.2 Hz,





1H), 6.88 (d, J = 15.6 Hz,





1H),





4.84-4.79 (m, 1H),





4.65-4.59 (m, 1H),





4.03-3.95 (m, 1H),





3.87-3.81 (m, 1H), 1.25 (d, J = 6.0 Hz,





3H)


P2012

628.89 ([M + H]+)
(300 MHz, DMSO-d6) δ
3406, 1643,





8.51 (d, J = 8.7 Hz, 1H),
1163, 583





8.41 (t, J = 6.0 Hz, 1H),





7.88 (s, 1H), 7.82 (s,





1H), 7.45-7.34 (m, 3H),





6.87 (dd, J = 15.9, 8.7 Hz,





1H), 6.74 (d, J = 15.6 Hz,





1H),





4.82-4.75 (m, 1H), 4.65-4.57 (m,





1H), 3.98-3.78 (m, 2H),





2.36 (s, 3H), 1.26 (d, J = 7.2 Hz,





3H)


P2036

674.7 ([M + H]+)
(300 MHz, DMSO-d6) δ
3296, 1651,





8.61 (d, J = 7.8 Hz, 1H),
1113, 534





8.26 (t, J = 5.7 Hz, 1H),





7.92-7.88 (m, 2H),





7.84 (s, 2H), 7.61 (d, J = 7.8 Hz,





1H), 7.42 (d, J = 7.8 Hz,





1H), 7.00 (dd, J = 15.9,





9.3 Hz, 1H),





6.77 (d, J = 15.9 Hz,





1H), 6.20-5.80 (m,





1H), 4.83-4.74 (m,





1H), 4.51-4.42 (m,





1H), 3.61-3.31 (m,





2H), 1.31 (d, J = 7.5 Hz,





3H)


P2038

662.7 ([M − H]+)
(300 MHz, DMSO-d6) δ
3292, 1650,





8.69 (d, J = 7.2 Hz, 1H),
1115, 747,





8.30 (bs, 1H), 7.98 (s,
681





1H), 7.89-7.85 (m,





4H), 7.57 (d, J = 8.1 Hz,





1H), 7.42 (d, J = 7.8 Hz,





1H), 7.09 (dd, J = 15.9,





9.6 Hz, 1H), 6.88 (d, J = 15.9 Hz,





1H),





6.18-5.81 (m, 1H),





4.84-4.78 (m, 1H),





4.50-4.45 (m, 1H),





3.50-3.45 (m, 2H), 1.29 (d, J = 7.2 Hz,





3H)


P2041

656.6 ([M + H]+)
(400 MHz, DMSO-d6) δ
3305, 1645,





8.56 (d, J = 7.2 Hz, 1H),
1167, 559





8.10 (t, J = 5.2 Hz, 1H),





7.92-7.88 (m, 2H),





7.84 (s, 2H), 7.60 (d, J = 8.0 Hz,





1H), 7.42 (d, J = 8.0 Hz,





1H), 6.99 (dd, J = 16.0,





9.6 Hz, 1H),





6.76 (d, J = 16.0 Hz,





1H), 4.81-4.74 (m,





1H), 4.50-4.36 (m,





3H), 3.56-3.36 (m,





2H), 1.29 (d, J = 6.8 Hz,





3H)


P2043

646.9 ([M + H]+)
(300 MHz, DMSO-d6) δ
3291, 1651,





8.64 (d, J = 7.8 Hz, 1H),
1115, 588





8.15 (t, J = 5.7 Hz, 1H),





7.97 (s, 1H)





7.90-7.85 (m, 4H), 7.57 (d, J = 8.0 Hz,





1H), 7.09 (dd, J = 15.9,





9.3 Hz, 1H),





6.88 (d, J = 15.6 Hz, 1H),





4.84-4.78 (m, 1H),





4.51-4.42 (m, 2H),





4.37-4.33 (m, 1H),





3.45-3.42 (m, 2H), 1.28 (d, J = 7.8 Hz,





3H)


P2056
91-94
706.8 ([M + H]+)
(400 MHz, DMSO-d6) δ





8.57 (d, J = 7.2 Hz, 1H),





8.09 (t, J = 5.2 Hz, 1H),





7.92-7.88 (m, 2H),





7.84 (s, 2H), 7.60 (d, J = 7.6 Hz,





1H), 7.43 (d, J = 7.6 Hz,





1H), 6.99 (dd, J = 15.6,





9.1 Hz, 1H),





6.76 (d, J = 15.6 Hz,





1H), 4.81-4.77 (m,





1H), 4.40-4.36 (m,





1H), 3.40-3.25 (m, 2H)





2.44-2.32 (m, 2H),





1.28 (d, J = 6.8 Hz, 3H)


P2058

696.8 ([M + H]+)
(300 MHz, DMSO-d6) δ
3309, 1650,





8.66 (s, 1H), 8.14 (s,
1141





2H), 7.97 (s, 1H),





7.89-7.85 (m, 3H) 7.57 (d, J = 8.1





1H), 7.06 (dd, J = 16.2,





9.0 Hz, 1H),





6.88 (d, J = 16.2 Hz, 1H),





4.82-4.81 (m, 1H),





4.41-4.37 (m, 1H)





3.38-2.99 (m, 2H),





2.44-2.36 (m, 2H) 1.27 (d, J = 7.2 Hz,





3H)





a1H NMR spectral data were acquired using a 400 MHz instrument in CDCl3 except where noted. HRMS data are noted observed value (theoretical value).













TABLE 2C







Analytical Data for Compounds in Table 1C.











Compound



IR (cm−1);


Number
mp (° C.)
ESIMS
1H NMR (δ)a
19F NMR (δ)





FA1

562.89 ([M + H]+)
(400 MHz, DMSO-d6)
3418, 1658,





δ 8.65 (t, J = 5.2 Hz,
1114, 749





1H), 8.28 (t, J = 6.0 Hz,





1H), 7.91 (s, 2H),





7.78 (s, 1H), 7.58 (d, J = 8.0 Hz,





1H), 7.50 (d, J = 8.0 Hz,





1H), 7.01 (dd, J = 15.6,





9.2 Hz, 1H),





6.78 (d, J = 15.6 Hz,





1H), 4.86-4.79 (m,





1H), 3.90 (d, J = 6.0 Hz,





2H),





3.59-3.48 (m, 3H)


FA2

542.93 ([M + H]+)
(400 MHz, DMSO-d6)
3430, 1646,





δ 8.45 (t, J = 6.0 Hz,
1113, 749





1H), 8.29 (t, J = 4.5 Hz,





1H), 7.89 (s, 2H),





7.45-7.34 (m, 3H),





6.87 (dd, J = 15.7, 6.9 Hz,





1H), 6.75 (d, J = 15.8 Hz,





1H),





4.85-4.80 (m, 1H), 3.87 (d, J = 4.8 Hz,





2H),





3.57-3.47 (m, 3H), 2.42 (s, 3H)


FA3

606.78 ([M + H]+)
(400 MHz, DMSO-d6)
3420, 1654,





δ 8.65 (t, J = 5.6 Hz,
114, 749, 558





1H), 8.27 (t, J = 5.6 Hz,





1H), 7.93-7.91 (m,





2H), 7.62-7.58 (m,





2H), 7.46 (d, J = 8.0 Hz,





1H), 7.00 (dd, J = 15.2,





9.2 Hz, 1H),





6.77 (d, J = 15.6 Hz, 1H),





4.85-4.81 (m, 1H),





3.89 (d, J = 6.0 Hz,





1H), 3.59-3.48 (m,





2H), 3.17-3.08 (m,





2H)


FA4

599.00 ([M + H]+)
(400 MHz, CDCl3) δ





9.81 (s, 1H), 8.06 (d, J = 7.1 Hz,





1H), 7.70 (d,





J = 5.5 Hz, 1H),





7.44 (s, 1H), 7.37 (t, J = 2.7 Hz,





2H), 7.20 (s, 1H),





6.82 (d, J = 15.9 Hz,





1H), 6.50 (dd, J = 16.0,





8.5 Hz, 1H), 4.14 (m,





3H), 3.89 (m, 2H)


FA5

613.10 ([M + H]+)
(400 MHz, CDCl3) δ





7.45 (s, 1H), 7.41 (s,





2H), 7.29 (s, 1H),





7.28 (s, 1H), 6.84 (m, 2H),





6.43 (dd, J = 16.0, 8.3 Hz,





1H), 4.25 (d, J = 5.4 Hz,





2H), 4.10 (m,





1H), 3.97 (qd, J = 9.0,





6.4 Hz, 2H), 3.87 (s,





3H)


FA6

545.92 ([M + H]+)
(400 MHz, DMSO-d6)
3369, 1694,





δ 8.56 (t, J = 6.4 Hz,
1164, 713





1H), 8.51 (t, J = 5.6 Hz,





1H), 7.82 (d, J = 6.4 Hz,





2H), 7.56 (d, J = 8.0 Hz,





1H), 6.81 (d, J = 8.4 Hz,





1H), 6.75 (s,





1H), 6.72 (dd, J = 15.6,





6.8 Hz, 1H), 6.62 (d, J = 15.6 Hz,





1H),





6.51 (bs, 2H),





4.82-4.78 (m, 1H),





3.96-3.85 (m, 4H)


FA7

638.78 ([M + H]+)
(300 MHz, CDCl3) δ
3284, 1667,





7.62-7.56 (m, 2H),
1166, 744,





7.46-7.37 (m, 2H),
591





6.77-6.76 (m, 1H),





6.56 (d, J = 14.1 Hz, 1H),





6.43 (dd, J = 15.9, 7.8 Hz,





1H), 4.14-4.07 (m,





3H), 3.61-3.54 (m, 2H),





2.42-2.34 (m, 2H)


FA8

588.87 ([M + H]+)
(300 MHz, DMSO-d6) δ
3297, 1658,





8.68 (t, J = 5.7 Hz, 1H),
1165





8.56 (t, J = 6.6 Hz, 1H),





7.91 (s, 1H),





7.61-7.58 (m, 1H), 7.45-7.39 (m,





3H), 6.95 (dd, J = 15.9,





9.3 Hz, 1H), 6.75 (d, J = 15.9 Hz,





1H),





4.76-4.64 (m, 1H),





4.06-3.92 (m, 4H), 3.90 (s, 3H)


FA9

624.92 ([M + H]+)
(300 MHz, DMSO-d6)
3430, 1651,





δ 9.81 (bs, 1H), 8.69 (s,
1166, 750





1H), 7.90 (s, 2H),





7.78 (s, 1H), 7.59-7.58 (m,





2H), 7.02 (dd, J = 15.8,





9.3 Hz, 1H), 6.78 (d, J = 15.8 Hz,





1H),





4.86-4.79 (m, 1H),





4.57-4.52 (m, 2H), 1.60 (s,





6H)


FA10

640.9 ([M + H]+)
(300 MHz, DMSO-d6)
3434, 1260,





δ 10.41 (s, 1H),
750





9.68 (bs, 1H), 7.90 (s, 2H),





7.76-7.67 (m, 1H),





7.53 (d, J = 8.1 Hz,





1H), 7.42 (d, J = 7.8 Hz,





1H), 6.97 (dd, J = 15.6,





8.7 Hz, 1H),





6.77 (d, J = 15.6, 1H),





4.86 (t, J = 9.3 Hz, 1H),





4.55-4.47 (m, 2H), 1.75 (s,





6H)


FA11

668.8 ([M + H]+)
(300 MHz, DMSO-d6)
3425, 1651,





δ 9.80 (bs, 1H), 8.69 (s,
1261, 750





1H), 7.92-7.90 (m,





3H), 7.60-7.55 (m,





2H), 7.01 (dd, J = 15.5,





9.1 Hz, 1H),





6.77 (d, J = 15.6 Hz, 1H),





4.84-4.30 (m, 1H),





4.57-4.52 (m, 2H),





1.60 (s, 6H)


FA12

660.8 ([M + 2H]+)
(300 MHz, DMSO-d6)
3430, 1651,





δ 9.87 (bs, 1H),
1261, 750





8.76 (bs, 1H), 7.98 (s, 1H),





7.95-7.91 (m, 3H),





7.83 (d, J = 8.1 Hz,





1H), 7.09 (dd, J = 15.9,





9.3 Hz, 1H),





6.89 (d, J = 15.9, 1H),





4.89 (t, J = 9.6 Hz, 1H),





4.57-4.51 (m, 2H), 1.58 (s,





6H)


FA13

606.8 ([M + H]+)
(300 MHz, DMSO-d6)
3418, 1651,





δ 10.36 (s, 1H),
1164, 749





8.67 (bs, 1H), 8.56 (bs, 1H),





7.92 (s, 1H),





7.61-7.58 (m, 3H), 7.44 (d, J = 7.8 Hz,





1H),





6.96 (dd, J = 15.4, 8.8 Hz,





1H), 6.74 (d, J = 15.7 Hz,





1H),





4.61-4.70 (m, 1H),





4.04-3.90 (m, 4H)


FA14

611.9 ([M + H]+)
(400 MHz, CDCl3) δ
19F NMR





7.69 (s, 1H), 7.62 (d, J = 1.6 Hz,
(376 MHz,





1H), 7.53 (d,
CDCl3) δ-





J = 8.0 Hz, 1H),
68.59





7.39 (m, 3H), 6.54 (d, J = 15.9 Hz,





1H), 6.40 (dd,





J = 15.9, 7.8 Hz, 1H),





6.28 (s, 1H), 4.21 (d, J = 5.7 Hz,





2H), 4.12 (m,





1H), 1.69 (s, 6H)


FA15

643.19 ([M + H]+)
(400 MHz, CDCl3) δ
19F NMR





7.60 (d, J = 1.6 Hz,
(376 MHz,





1H), 7.51 (d, J = 8.0 Hz,
CDCl3) δ-





1H), 7.40 (s, 2H),
68.62





7.36 (dd, J = 8.1, 1.6 Hz,





1H), 6.66 (d, J = 10.0 Hz,





2H), 6.53 (d, J = 15.9 Hz,





1H),





6.38 (dd, J = 15.9, 7.8 Hz,





1H), 4.11 (m, 1H),





3.12 (d, J = 6.2 Hz, 2H),





1.72 (s, 6H), 0.93 (s,





9H)


FA16

687.0 ([M + H]+)
(300 MHz, DMSO-d6)
3433, 1640,





δ 8.61-8.53 (m, 2H),
1163, 749





8.11 (s, 1H), 7.91 (s,





2H), 7.62 (d, J = 8.4 Hz,





1H), 7.36 (d, J = 8.1 Hz,





1H), 6.98 (dd,





J = 15.9, 9.3 Hz, 1H),





6.74 (d, J = 15.9 Hz,





1H), 4.85-4.82 (m,





1H), 4.50-4.45 (m,





1H), 4.00-3.88 (m,





2H), 1.36 (d, J = 7.5 Hz,





3H)


FA17

587.1 ([M + H]+)
(300 MHz, DMSO-d6)
3419, 1644,





δ 8.60-8.53 (m, 2H),
1162, 748





7.91-7.85 (m, 3H),





7.54 (d, J = 8.1 Hz,





1H), 7.40 (d, J = 8.1 Hz,





1H), 7.02 (dd, J = 17.4,





11.1 Hz, 1H),





6.92 (dd, J = 15.9, 9.0 Hz,





1H), 6.81 (d, J = 15.9 Hz,





1H), 5.95 (d, J = 17.1 Hz,





1H),





5.33 (d, J = 11.7 Hz, 1H),





4.87-4.80 (m, 1H),





4.47-4.43 (m, 1H),





4.01-3.87 (m, 2H),





1.31 (d, J = 6.9 Hz, 3H)


FA18

573.2 ([M + H]+)
(300 MHz, DMSO-d6)
3422, 1649,





δ 8.62-8.56 (m, 2H),
1164, 809





7.91-7.86 (m, 3H),





7.56 (d, J = 9.3 Hz,





1H), 7.42 (d, J = 8.1 Hz,





1H), 7.11 (dd, J = 17.4,





11.1 Hz, 1H),





6.98 (dd, J = 15.9, 9.3 Hz,





1H), 6.82 (d, J = 15.9 Hz,





1H), 5.96 (d, J = 16.8 Hz,





1H),





5.34 (d, J = 12.0 Hz, 1H),





4.87-4.81 (m, 1H),





4.01-3.89 (m, 4H)


FA19

667.0 ([M + H]+)
(300 MHz, DMSO-d6)
3288, 1645,





δ 8.64-8.58 (m, 2H),
1164, 743,





7.92-7.89 (m, 3H),
563





7.60 (d, J = 8.1 Hz,





1H), 7.37 (d, J = 7.8 Hz,





1H), 7.00 (dd, J = 15.3,





8.7 Hz, 1H),





6.77 (d, J = 15.6 Hz, 1H),





4.86-4.79 (m, 1H),





4.49-4.42 (m, 1H),





4.07-3.81 (m, 2H),





1.65-1.59 (m, 2H),





1.40-1.30 (m, 2H),





0.89 (t, J = 6.9 Hz, 3H)


FA20

609.1 ([M + H]+)
(400 MHz, DMSO-d6)
3422, 2926,





δ 8.74 (d J = 7.6 Hz,
1651, 1165,





1H), 8.59 (t, J = 6.4 Hz,
783





1H), 7.95 (s, 1H),





7.89 (d, J = 7.2 Hz, 1H),





7.72 (s, 1H), 7.55 (d, J = 7.2 Hz,





2H),





7.02 (dd, J = 16.0, 8.8 Hz,





1H), 6.87 (d, J = 15.6 Hz,





1H),





4.76-4.72 (m, 1H),





4.51-4.47 (m, 1H),





3.99-3.88 (m, 2H), 2.42 (s, 3H),





1.29 (d, J = 7.2 Hz,





3H)


FA21

673.0 ([M + H]+)
(300 MHz, DMSO-d6)
3429, 1650,





δ 8.74 (d, J = 7.5 Hz,
1165, 804





1H), 8.59 (t, J = 6.3 Hz,





1H), 7.98 (s, 1H),





7.91-7.85 (m, 3H), 7.56 (d,





J = 8.1 Hz, 1H),





7.09 (dd, J = 15.9, 9.3 Hz,





1H), 6.88 (d, J = 15.6 Hz,





1H),





4.88-4.81 (m, 1H),





4.52-4.57 (m, 1H),





4.04-3.85 (m, 2H), 1.29 (t, J = 6.9 Hz,





3H)


FA22

681.0 ([M − H]−)
(300 MHz, DMSO-d6)
3298, 1651,





δ 8.65 (d, J = 7.5 Hz,
1164, 689,





1H), 8.55 (t, J = 5.7 Hz,
536





1H), 7.91-7.85 (m,





2H), 7.48-7.39 (m,





2H), 7.31-7.26 (m,





1H), 7.00 (dd, J = 15.9,





9.3 Hz, 1H), 6.77 (d, J = 15.6 Hz,





1H),





4.86-4.82 (m, 1H),





4.50-4.46 (m, 1H),





4.00-3.88 (m, 2H), 1.31 (t, J = 7.2 Hz,





3H)


FA23

651.2 ([M + H]+)
(400 MHz, CDCl3) δ
19F NMR





7.61 (d, J = 1.6 Hz,
(376 MHz,





1H), 7.51 (d, J = 8.0 Hz,
CDCl3) δ −68.61,





1H), 7.40 (s, 2H),
−96.22





7.37 (dd, J = 8.1, 1.6 Hz,





1H), 6.85 (t, J = 6.2 Hz,





1H), 6.53 (d, J = 15.9 Hz,





1H), 6.42 (s,





1H), 6.38 (dd, J = 15.9,





7.8 Hz, 1H), 4.11 (m,





1H), 3.70 (td, J = 13.3,





6.3 Hz, 2H), 1.67 (m,





9H)


FA24

672.9 ([M + H]+)
(400 MHz, DMSO-d6)
3410, 1653,





δ 8.49 (t, J = 6.0 Hz,
1164, 812





1H), 8.42 (t, J = 6.4 Hz,





1H), 7.98 (s, 1H),





7.76 (s, 2H), 7.49-7.47 (m,





1H), 7.24 (d, J = 8.0 Hz,





1H), 6.82 (dd, J = 15.6,





9.2 Hz, 1H),





6.59 (d, J = 16.4 Hz, 1H),





4.70-4.65 (m, 1H),





3.89-3.75 (m, 4H)


FA25

603.0 ([M + H]+)
(400 MHz, DMSO-d6)
3288, 1676,





δ 8.61 (t, J = 6.4 Hz,
1164, 809





1H), 8.37 (d, J = 8.0 Hz,





1H), 7.89 (s, 2H),





7.45 (s, 1H), 7.40 (d, J = 8.4 Hz,





1H), 7.33 (d, J = 8.0 Hz,





1H),





6.86 (dd, J = 16.0, 8.8 Hz,





1H), 6.75 (d, J = 15.6 Hz,





1H),





4.85-4.80 (m, 1H), 4.47-4.41 (m,





1H), 4.02-3.96 (m,





1H), 3.90-3.83 (m,





1H), 2.32 (s, 3H),





1.67-1.61 (m, 2H),





1.42-1.28 (m, 2H), 0.89 (t, J = 7.6 Hz,





3H)


FA26
108-111
726.9 ([M + H]+)
(300 MHz, DMSO-d6)





δ 8.65 (d, J = 7.2 Hz,





1H), 8.55 (t, J = 6.3 Hz,





1H), 8.04 (s, 1H),





7.92 (s, 1H), 7.84-7.76 (m,





1H), 7.61 (d, J = 7.8 Hz,





1H), 7.42 (d, J = 7.8 Hz,





1H), 7.01 (dd, J = 15.6,





9.0 Hz, 1H),





6.77 (d, J = 15.9 Hz,





1H), 4.84-4.78 (m,





1H), 4.51-4.46 (m,





1H), 4.00-3.88 (m,





2H), 1.31 (d, J = 7.5 Hz,





3H)


FA27
103-107
717.1 ([M + H]+)
(300 MHz, DMSO-d6)





δ 8.74 (d, J = 6.9 Hz,





1H), 8.59 (t, J = 6.0 Hz,





1H), 8.06 (s, 1H),





7.91-7.79 (m, 3H), 7.56 (d, J = 8.1 Hz,





1H),





7.09 (dd, J = 15.9, 8.6 Hz,





1H), 6.88 (d, J = 15.3 Hz,





1H),





4.84-4.81 (m, 1H),





4.52-4.47 (m, 1H),





3.99-3.88 (m, 2H), 1.29 (d, J = 6.9 Hz,





3H)


FA28

588.9 ([M + H]+)
(300 MHz, DMSO-d6)
3361, 2960,





δ 8.59 (t, J = 6.6 Hz,
1690, 1166,





1H), 8.51 (d, J = 6.9 Hz,
819





1H), 7.88 (s, 2H),





7.22 (s, 2H),





6.75-6.63 (m, 2H),





4.83-4.77 (m, 1H),





4.50-4.49 (m, 1H),





4.00-3.87 (m, 2H), 2.21 (s,





6H), 1.33-1.22 (m,





3H)


FA29

600.8 ([M + H]+)
(400 MHz, DMSO-d6)
3288, 1687,





δ 8.63 (d, J = 7.2 Hz,
1164, 748,





1H), 8.55 (t, J = 6.4 Hz,
568





1H), 7.86 (s, 2H),





7.77 (d, J = 2.0 Hz, 1H),





7.66 (d, J = 8.4 Hz,





1H), 7.54 (d, J = 7.2 Hz,





1H), 7.47 (dd, J = 10.0,





8.0 Hz, 1H),





7.39 (d, J = 7.6 Hz, 1H),





6.94 (dd, J = 15.6, 9.3 Hz,





1H), 6.63 (d, J = 15.6 Hz,





1H),





4.48-4.43 (m, 1H),





4.05-3.92 (m, 2H), 1.64 (t, J = 19.2 Hz,





3H),





1.30 (d, J = 6.8 Hz, 3H)


FA30

655.0 ([M + H]+)
(300 MHz, DMSO-d6)
3418, 1717,





δ 8.64 (d, J = 7.5 Hz,
1165, 748,





1H), 8.58 (t, J = 6.3 Hz,
525





1H), 7.95-7.91 (m,





2H), 7.66 (s, 2H),





7.60 (d, J = 8.1 Hz, 1H),





7.42 (d, J = 7.8 Hz,





1H), 6.99 (dd, J = 15.9,





9.3 Hz, 1H), 6.78 (d, J = 15.9 Hz,





1H),





4.88-4.82 (m, 1H),





4.50-4.46 (m, 1H),





4.00-3.85 (m, 2H), 1.31 (d, J = 7.5 Hz,





3H)


FA31

598.9 ([M + H]+)
(300 MHz, DMSO-d6)
3406, 1645,





δ 8.65 (d, J = 7.5 Hz,
1163, 749,





1H), 8.55 (t, J = 5.7 Hz,
597





1H), 7.89 (s, 1H),





7.60 (d, J = 8.1 Hz, 1H),





7.46 (s, 1H), 7.41 (d, J = 7.8 Hz,





2H),





7.31 (s, 1H), 6.96 (dd, J = 15.9,





8.7 Hz, 1H),





6.76 (d, J = 15.9 Hz, 1H),





4.71 (t, J = 9.3 Hz, 1H),





4.50 (t, J = 7.5 Hz, 1H),





4.00-3.88 (m, 2H),





2.67-2.60 (m, 2H),





1.31 (d, J = 7.2 Hz,





3H), 1.21 (t, J = 7.5 Hz,





3H)


FA32

666.9 ([M + H]+)
(300 MHz, DMSO-d6)
3288, 1645,





δ 8.68 (s, 1H), 8.54 (d,
1165, 750





J = 8.4 Hz, 1H),





7.96-7.91 (m, 3H), 7.59 (d, J = 8.1 Hz,





1H), 7.33 (d,





J = 6.6 Hz, 1H),





6.98 (dd, J = 15.6, 8.0 Hz,





1H), 6.77 (d, J = 15.9,





1H), 4.88-4.72 (m,





1H), 4.36-4.31 (m,





1H), 4.07-3.81 (m,





2H), 2.06-1.99 (m,





1H), 0.95-0.85 (m,





6H)


FA33

656.9 ([M + H]+)
(300 MHz, DMSO-d6)
3294, 1650,





δ 8.71 (d, J = 6.3 Hz
1165, 810





1H), 8.65 (d, J = 8.4 Hz,





1H), 7.98 (s, 1H),





7.92-7.87 (m, 3H),





7.45 (d, J = 8.1 Hz, 1H),





7.03 (dd, J = 1 6 Hz,





8.0 Hz, 1H), 6.89 (d, J = 15.9 Hz,





1H),





4.88-4.82 (m, 1H),





4.35-4.10 (m, 1H),





4.07-3.81 (m, 2H),





2.06-1.99 (m, 1H),





0.95-0.85 (m, 6H)


FA34

608.85 ([M + H]+)
(300 MHz, DMSO-d6)
768, 721,





δ 9.01 (t, J = 6.0, 1H),
416, 337, 164





8.37 (t, J = 6.4 Hz,





1H), 8.08 (s, 1H),





8.01-7.96 (m, 1H),





7.88-7.86 (m, 2H), 7.64 (d, J = 7.6 Hz,





1H),





7.05 (dd, J = 16.4, 8.8 Hz,





1H), 6.91 (d, J = 15.6 Hz,





1H),





4.87-4.80 (m, 1H),





3.98-3.91 (m, 4H), 3.38 (s, 3H)





a1H NMR spectral data were acquired using a 400 MHz instrument in CDCl3 except where noted. HRMS data are noted observed value (theoretical value).













TABLE 3







Assays Results Part 1












Compound
BAW
CEW
GPA



Number
Rating
Rating
Rating







AC1
D
D
B



AC2
C
C
C



AC3
D
D
B



AC4
D
A
B



AC5
D
D
B



AC6
D
A
B



AC7
A
A
B



AC8
D
B
B



AC9
A
A
B



AC10
A
A
B



AC11
A
A
D



AC12
A
A
D



AC13
A
A
B



AC14
A
B
D



AC15
A
A
B



AC16
A
A
C



AC17
A
A
B



AC18
A
A
B



AC19
D
D
B



AC20
A
A
C



AC21
D
D
C



AC22
A
A
D



AC23
A
A
B



AC24
A
A
D



AC25
A
A
D



AC26
A
A
B



AC27
A
A
B



AC28
A
A
B



AC29
A
A
B



AC30
A
A
B



AC31
A
A
B



AC32
A
A
B



AC33
A
A
B



AC34
A
A
B



AC35
A
A
C



AC36
A
A
B



AC37
A
A
B



AC38
A
A
C



AC39
A
A
C



AC40
A
A
D



AC41
A
D
D



AC42
A
D
D



AC43
A
A
B



AC44
A
A
B



AC45
A
A
D



AC46
A
A
D



AC47
D
D
B



AC48
A
A
B



AC49
A
A
B



AC50
A
D
B



AC51
A
A
B



AC52
A
A
B



AC53
A
A
B



AC54
A
A
B



AC57
A
A
B



AC58
A
A
B



AC59
A
A
B



AC60
A
A
B



AC61
A
A
B



AC62
A
A
D



AC63
A
A
B



AC64
A
A
B



AC65
A
A
B



AC66
A
A
B



AC67
A
A
B



AC68
A
A
D



AC69
A
A
A



AC70
D
D
B



AC71
A
A
B



AC72
A
A
B



AC75
A
A
B



AC76
A
A
D



AC77
A
A
B



AC78
A
A
A



AC79
A
A
A



AC80
A
A
B



AC81
A
D
D



AC82
A
A
B



AC83
A
A
B



AC84
A
A
D



AC85
A
A
B



AC86
A
A
D



AC87
A
A
B



AC89
A
A
B



AC90
A
A
C



AC91
A
A
C



AC92
A
A
C



AC93
A
D
C



AC94
D
B
B



AC95
A
A
C



AC96
D
D
C



AC97
D
D
C



AC98
A
A
C



AC99
A
A
C



AC100
C
C
C



AC101
D
D
C



AC102
D
A
C



AC103
A
A
D



AC104
A
A
B



AC105
A
A
D



AC106
A
A
B



AC107
B
A
D



AC108
B
D
D



AC109
D
D
C



AC110
A
A
C



AC111
A
A
C



AC112
A
A
C



AC113
B
A
D



AC114
A
B
D



AC115
A
A
D



AC116
C
C
C



AC117
A
D
B



AC118
A
D
D



BC1
A
A
D



BC2
A
A
D



BC3
A
A
D



BC4
A
A
B



BC5
A
A
B



BC6
A
A
D



BC7
A
A
D



BC8
A
A
B



BC9
A
A
D



BC10
A
A
B



BC11
C
C
C



BC12
C
C
C



BC13
A
A
D



BC14
A
D
D



CC1
D
D
D



CC2
A
A
B



CC3
A
A
D



CC4
A
B
B



CC5
A
A
B



CC6
A
A
B



CC7
A
A
B



CC8
A
A
D



CC9
A
A
B



CC10
A
A
B



CC11
A
A
B



CC12
D
D
B



CC13
A
A
B



CC14
A
D
D



CC15
A
A
B



CC16
A
A
B



CC17
A
A
B



CC18
A
A
B



CC19
A
A
B



CC20
A
A
D



CC21
A
A
D



CC22
A
A
B



CC23
A
A
B



CC24
A
A
D



CC25
A
A
B



CC26
A
D
B



CC27
A
A
D



CC28
A
A
D



CC29
A
A
B



CC30
A
A
D



CC31
B
D
C



CC32
A
A
B



CC33
A
A
B



CC34
A
A
B



CC35
D
D
D



CC36
A
A
D



CC37
A
A
D



CC38
A
A
D



CC39
D
D
B



CC40
D
A
D



CC41
D
D
B



CC42
D
D
D



CC43
A
B
B



CC44
A
A
B



CC45
A
A
D



CC46
D
A
C



CC47
D
D
C



CC48
D
D
C



CC49
D
D
D



CC50
A
A
D



CC51
A
A
D



CC52
A
D
D



CC53
D
D
B



CC54
A
A
C



DC1
A
A
D



DC2
D
D
C



DC3
B
D
C



DC4
A
D
C



DC5
D
D
C



DC6
D
D
C



DC7
A
D
C



DC8
A
D
C



DC9
D
D
C



DC10
D
D
C



DC11
A
D
C



DC12
A
A
B



DC13
A
A
C



DC14
D
D
C



DC15
D
D
C



DC16
A
A
C



DC17
A
A
C



DC18
A
A
C



DC19
A
A
C



DC20
A
D
C



DC21
D
D
C



DC22
D
D
C



DC23
D
A
C



DC24
D
D
C



DC25
D
D
C



DC26
D
D
C



DC27
D
D
C



DC28
A
A
B



DC29
A
A
C



DC30
A
A
C



DC31
A
A
B



DC32
D
D
C



DC33
A
A
C



DC34
A
A
B



DC35
A
A
B



DC36
D
D
C



DC37
A
A
C



DC38
A
A
C



DC39
A
A
C



DC40
A
A
C



DC41
A
A
C



DC42
A
A
C



DC43
A
A
C



DC44
A
A
C



DC45
A
A
C



DC46
A
A
C



DC47
A
A
C



DC48
A
A
C



DC49
A
A
C



DC50
A
A
C



DC51
A
A
C



DC52
D
D
C



DC53
D
A
C



DC54
D
D
C



DC55
D
D
C



DC56
D
D
C



DC57
A
A
C



DC58
D
D
C



DC59
D
D
C



DC60
A
A
C



DC61
D
D
C



DC62
A
A
C



DC63
A
A
C



DC64
D
D
C



DC65
D
A
C



DC66
A
A
C



DC67
A
A
C



DC68
A
A
C



DC69
D
D
C



DC70
A
A
C

















TABLE 4







Assays Results F Compounds












Compound
BAW
CL
GPA



Number
Rating
Rating
Rating







Fl
A
A
B



F2
A
A
C



F3
A
A
C



F4
A
A
C



F5
A
A
C



F6
C
C
C



F7
A
A
C



F8
A
A
C



F8A
A
A
C



F9
A
A
C



F10
A
A
C



F11
A
A
C



F12
A
A
C



F13
A
A
C



F14
A
A
C



F15
A
A
C



F15A
A
A
C



F16
A
A
C



F16A
A
A
C



F17
A
A
C



F18
A
A
C



F19
A
A
C



F20
A
A
C



F20A
A
A
A



F20B
A
A
C



F20C
A
A
C



F21
A
A
C



F22
A
A
C



F23
D
A
C



F23A
A
A
C



F24
A
A
C



F25
A
A
C



F26
A
A
C



F27
A
A
C



F28
A
A
C



F29
A
A
C



F30
A
A
C



F31
A
A
C

















TABLE 5







Assay Results Prophetic Compounds Subsequently Exemplified










Compound
BAW
CL
GPA


Number
Rating
Rating
Rating





P1
A
A
C


P2
D
A
C


P12
A
A
C


P14
B
A
C


P15
A
A
C


P82
A
A
C


P84
A
A
C


P156
A
A
C


P226
A
A
C


P228
A
A
C


P298
D
A
B


P300
A
A
C


P442
A
A
C


P444
A
A
C


P514
A
A
C


P516
A
A
C


P568
A
A
C


P586
A
A
C


P588
A
A
C


P660
A
A
C


P730
A
A
C


P732
A
A
C


P802
A
A
C


P804
A
A
C


P1090
A
A
C


P1092
A
A
C


P1197
A
A
C


P1269
A
A
C


P1340
A
A
C


P1411
A
A
B


P1483
A
A
C


P1556
A
A
C


P1558
A
A
C


P1559
A
A
C


P1560
A
A
C


P1564
A
A
C


P1566
A
A
A


P1589
A
A
C


P1591
A
A
C


P1592
A
A
C


P1599
A
A
C


P1601
A
A
B


P1603
A
A
C


P1611A
A
A
C


P1613A
A
A
C


P1616
A
A
C


P1616A
A
A
C


P1618A
A
A
C


P1621
A
A
C


P1623
A
A
C


P1624
A
A
A


P1631A
A
A
B


P1633A
A
A
C


P1636
A
A
C


P1638
A
A
C


P1640
D
A
D


P1641
A
A
C


P1691
A
A
C


P1693
A
A
C


P1696
A
A
C


P1698
A
A
C


P1776
A
A
C


P1781
A
A
C


P1806
A
A
C


P1808
A
A
C


P1862
A
A
C


P1864
A
A
C


P1866
A
A
C


P1969*
A
A
C


P1970
A
A
C


P1971
A
A
C


P1972
A
A
C


P2009
A
A
C


P2010
A
A
C


P2011
A
A
C


P2012
A
A
C


P2036
A
A
C


P2038
A
A
C


P2041
A
A
C


P2043
A
A
C


P2056
A
A
C


P2058
A
A
C





*Performed at 12.5 ug/cm2













TABLE 6







Assay Results FA Compounds












Compound
BAW
CL
GPA



Number
Rating
Rating
Rating







FA1
A
A
C



FA2
A
A
C



FA3
A
A
C



FA4
A
A
C



FA5
A
A
C



FA6
A
A
C



FA7
A
A
C



FA8
B
A
C



FA9
A
A
C



FA10
B
B
C



FA11
B
A
D



FA12
A
A
C



FA13
D
A
C



FA14
A
A
C



FA15
A
A
C



FA16
A
A
A



FA17
A
A
C



FA18
A
A
C



FA19
A
A
C



FA20
A
A
C



FA21
A
A
C



FA22
A
A
C



FA23
A
A
C



FA24
A
A
C



FA25
A
A
C



FA26
A
A
C



FA27
A
A
C



FA28
A
A
C



FA29
A
A
C



FA30
A
A
C



FA31
A
A
C



FA32
A
A
C



FA33
A
A
C



FA34
D
A
C

## Claims

1. A composition comprising a molecule according to Formula One:




wherein:
(a) R1 is H;
(b) R2 is H, F, Cl, Br, I, or (C1-C8)alkyl;
(c) R3 is F, Cl, Br, I, (C1-C8)alkoxy, or halo(C1-C8)alkoxy;
(d) R4 is F, Cl, Br, I, or (C1-C8)alkyl;
(e) R5 is H;
(f) R6 is (C1-C8)haloalkyl;
(g) R7 is H;
(h) R8 is H;
(i) R9 is H;
(j) R10 is F, Cl, Br, I, (C1-C8)alkyl, halo(C1-C8)alkyl, S(O)2(C1-C8)alkyl, NR14R15, or (C2-C8)alkenyl;
(k) R11 is selected from C(═X5)N(R14)((C1-C8)alkylC(═X5)N(R14)(R15)) wherein each X5 is independently selected from O, or S;
(l) R12 is H, or (C1-C8)alkyl;
(m) R13 is H, or (C1-C8)alkoxy;
(n) R14 is H;
(o) R15 is halo(C1-C8)alkyl;
(r) X1 is CR12;
(s) X2 is CR13; and
(t) X3 is CR9.

2. A molecule according to claim 1 wherein R11 is selected from the group consisting of C(═O)N(H)(C((CH3)2)C(═O)N(H)(CH2CF3)),
C(═O)N(H)(CH(CH3))C(═O)N(H)(CH2CF3)),
C(═O)N(H)(CH(CH2CH3))C(═O)N(H)(CH2CF3)),
C(═O)N(H)(CH(CH3))C(═S)N(H)(CH2CF3)),
C(═O)N(H)(C((CH3)2)C(═S)N(H)(CH2CF3)), and
C(═S)N(H)(C((CH3)2)C(═S)N(H)(CH2CF3)).

3. A molecule according to claim 1 wherein R11 is selected from the group consisting of C(═(O or S))N(H)((C1-C8)alkyl)C(═(O or S))N(H)(halo(C1-C8)alkyl)).

4. A molecule according to claim 1 wherein R11 is selected from the group consisting of C(═O)N(H)(C((CH3)2)C(═O)N(H)(CH2CF3)),
C(═O)N(H)(CH(CH3))C(═O)N(H)(CH2CF3)),
C(═O)N(H)(CH(CH3))C(═S)N(H)(CH2CF3)),
C(═O)N(H)(C((CH3)2)C(═S)N(H)(CH2CF3)), and
C(═S)N(H)(C((CH3)2)C(═S)N(H)(CH2CF3)).

5. A molecule according to claim 1 wherein R11 is selected from the group consisting of C(═O)N(H)(C((CH3)2)C(═O)N(H)(CH2CF3)).

6. A composition according to claim 1 further comprising:
(a) one or more compounds having acaricidal, algicidal, avicidal, bactericidal, fungicidal, herbicidal, insecticidal, molluscicidal, nematicidal, rodenticidal, or virucidal properties; or
(b) one or more compounds that are antifeedants, bird repellents, chemosterilants, herbicide safeners, insect attractants, insect repellents, mammal repellents, mating disrupters, plant activators, plant growth regulators, or synergists; or
(c) both (a) and (b).

7. A composition according to claim 1 further comprising one or more compounds selected from: (3-ethoxypropyl)mercury bromide, 1,2-dichloropropane, 1,3-dichloropropene, 1-methylcyclopropene, 1-naphthol, 2-(octylthio)ethanol, 2,3,5-tri-iodobenzoic acid, 2,3,6-TBA, 2,3,6-TBA-dimethylammonium, 2,3,6-TBA-lithium, 2,3,6-TBA-potassium, 2,3,6-TBA-sodium, 2,4,5-T, 2,4,5-T-2-butoxypropyl, 2,4,5-T-2-ethylhexyl, 2,4,5-T-3-butoxypropyl, 2,4,5-TB, 2,4,5-T-butomethyl, 2,4,5-T-butotyl, 2,4,5-T-butyl, 2,4,5-T-isobutyl, 2,4,5-T-isoctyl, 2,4,5-T-isopropyl, 2,4,5-T-methyl, 2,4,5-T-pentyl, 2,4,5-T-sodium, 2,4,5-T-triethylammonium, 2,4,5-T-trolamine, 2,4-D, 2,4-D-2-butoxypropyl, 2,4-D-2-ethylhexyl, 2,4-D-3-butoxypropyl, 2,4-D-ammonium, 2,4-DB, 2,4-DB-butyl, 2,4-DB-dimethylammonium, 2,4-DB-isoctyl, 2,4-DB-potassium, 2,4-DB-sodium, 2,4-D-butotyl, 2,4-D-butyl, 2,4-D-diethylammonium, 2,4-D-dimethylammonium, 2,4-D-diolamine, 2,4-D-dodecylammonium, 2,4-DEB, 2,4-DEP, 2,4-D-ethyl, 2,4-D-heptylammonium, 2,4-D-isobutyl, 2,4-D-isoctyl, 2,4-D-isopropyl, 2,4-D-isopropylammonium, 2,4-D-lithium, 2,4-D-meptyl, 2,4-D-methyl, 2,4-D-octyl, 2,4-D-pentyl, 2,4-D-potassium, 2,4-D-propyl, 2,4-D-sodium, 2,4-D-tefuryl, 2,4-D-tetradecylammonium, 2,4-D-triethylammonium, 2,4-D-tris(2-hydroxypropyl) ammonium, 2,4-D-trolamine, 2iP, 2-methoxyethylmercury chloride, 2-phenylphenol, 3,4-DA, 3,4-DB, 3,4-DP, 4-aminopyridine, 4-CPA, 4-CPA-potassium, 4-CPA-sodium, 4-CPB, 4-CPP, 4-hydroxyphenethyl alcohol, 8-hydroxyquinoline sulfate, 8-phenylmercurioxyquinoline, abamectin, abscisic acid, ACC, acephate, acequinocyl, acetamiprid, acethion, acetochlor, acetophos, acetoprole, acibenzolar, acibenzolar-S-methyl, acifluorfen, acifluorfen-methyl, acifluorfen-sodium, aclonifen, acrep, acrinathrin, acrolein, acrylonitrile, acypetacs, acypetacs-copper, acypetacs-zinc, alachlor, alanycarb, albendazole, aldicarb, aldimorph, aldoxycarb, aldrin, allethrin, allicin, allidochlor, allosamidin, alloxydim, alloxydim-sodium, allyl alcohol, allyxycarb, alorac, alpha-cypermethrin, alpha-endosulfan, ametoctradin, ametridione, ametryn, amibuzin, amicarbazone, amicarthiazol, amidithion, amidoflumet, amidosulfuron, aminocarb, aminocyclopyrachlor, aminocyclopyrachlor-methyl, aminocyclopyrachlor-potassium, aminopyralid, aminopyralid-potassium, aminopyralid-tris(2-hydroxypropyl)ammonium, amiprofos-methyl, amiprophos, amisulbrom, amiton, amiton oxalate, amitraz, amitrole, ammonium sulfamate, ammonium α-naphthaleneacetate, amobam, ampropylfos, anabasine, ancymidol, anilazine, anilofos, anisuron, anthraquinone, antu, apholate, aramite, arsenous oxide, asomate, aspirin, asulam, asulam-potassium, asulam-sodium, athidathion, atraton, atrazine, aureofungin, aviglycine, aviglycine hydrochloride, azaconazole, azadirachtin, azafenidin, azamethiphos, azimsulfuron, azinphos-ethyl, azinphos-methyl, aziprotryne, azithiram, azobenzene, azocyclotin, azothoate, azoxystrobin, bachmedesh, barban, barium hexafluorosilicate, barium polysulfide, barthrin, BCPC, beflubutamid, benalaxyl, benalaxyl-M, benazolin, benazolin-dimethylammonium, benazolin-ethyl, benazolin-potassium, bencarbazone, benclothiaz, bendiocarb, benfluralin, benfuracarb, benfuresate, benodanil, benomyl, benoxacor, benoxafos, benquinox, bensulfuron, bensulfuron-methyl, bensulide, bensultap, bentaluron, bentazone, bentazone-sodium, benthiavalicarb, benthiavalicarb-isopropyl, benthiazole, bentranil, benzadox, benzadox-ammonium, benzalkonium chloride, benzamacril, benzamacril-isobutyl, benzamorf, benzfendizone, benzipram, benzobicyclon, benzofenap, benzofluor, benzohydroxamic acid, benzoximate, benzoylprop, benzoylprop-ethyl, benzthiazuron, benzyl benzoate, benzyladenine, berberine, berberine chloride, beta-cyfluthrin, beta-cypermethrin, bethoxazin, bicyclopyrone, bifenazate, bifenox, bifenthrin, bifujunzhi, bilanafos, bilanafos-sodium, binapacryl, bingqingxiao, bioallethrin, bioethanomethrin, biopermethrin, bioresmethrin, biphenyl, bisazir, bismerthiazol, bispyribac, bispyribac-sodium, bistrifluoron, bitertanol, bithionol, bixafen, blasticidin-S, borax, Bordeaux mixture, boric acid, boscalid, brassinolide, brassinolide-ethyl, brevicomin, brodifacoum, brofenvalerate, brofluthrinate, bromacil, bromacil-lithium, bromacil-sodium, bromadiolone, bromethalin, bromethrin, bromfenvinfos, bromoacetamide, bromobonil, bromobutide, bromocyclen, bromo-DDT, bromofenoxim, bromophos, bromophos-ethyl, bromopropylate, bromothalonil, bromoxynil, bromoxynil butyrate, bromoxynil heptanoate, bromoxynil octanoate, bromoxynil-potassium, brompyrazon, bromuconazole, bronopol, bucarpolate, bufencarb, buminafos, bupirimate, buprofezin, Burgundy mixture, busulfan, butacarb, butachlor, butafenacil, butamifos, butathiofos, butenachlor, butethrin, buthidazole, buthiobate, buthiuron, butocarboxim, butonate, butopyronoxyl, butoxycarboxim, butralin, butroxydim, buturon, butylamine, butylate, cacodylic acid, cadusafos, cafenstrole, calcium arsenate, calcium chlorate, calcium cyanamide, calcium polysulfide, calvinphos, cambendichlor, camphechlor, camphor, captafol, captan, carbamorph, carbanolate, carbaryl, carbasulam, carbendazim, carbendazim benzenesulfonate, carbendazim sulfite, carbetamide, carbofuran, carbon disulfide, carbon tetrachloride, carbophenothion, carbosulfan, carboxazole, carboxide, carboxin, carfentrazone, carfentrazone-ethyl, carpropamid, cartap, cartap hydrochloride, carvacrol, carvone, CDEA, cellocidin, CEPC, ceralure, Cheshunt mixture, chinomethionat, chitosan, chlobenthiazone, chlomethoxyfen, chloralose, chloramben, chloramben-ammonium, chloramben-diolamine, chloramben-methyl, chloramben-methylammonium, chloramben-sodium, chloramine phosphorus, chloramphenicol, chloraniformethan, chloranil, chloranocryl, chlorantraniliprole, chlorazifop, chlorazifop-propargyl, chlorazine, chlorbenside, chlorbenzuron, chlorbicyclen, chlorbromuron, chlorbufam, chlordane, chlordecone, chlordimeform, chlordimeform hydrochloride, chlorempenthrin, chlorethoxyfos, chloreturon, chlorfenac, chlorfenac-ammonium, chlorfenac-sodium, chlorfenapyr, chlorfenazole, chlorfenethol, chlorfenprop, chlorfenson, chlorfensulphide, chlorfenvinphos, chlorfluazuron, chlorflurazole, chlorfluren, chlorfluren-methyl, chlorflurenol, chlorflurenol-methyl, chloridazon, chlorimuron, chlorimuron-ethyl, chlormephos, chlormequat, chlormequat chloride, chlornidine, chlornitrofen, chlorobenzilate, chlorodinitronaphthalenes, chloroform, chloromebuform, chloromethiuron, chloroneb, chlorophacinone, chlorophacinone-sodium, chloropicrin, chloropon, chloropropylate, chlorothalonil, chlorotoluron, chloroxuron, chloroxynil, chlorphonium, chlorphonium chloride, chlorphoxim, chlorprazophos, chlorprocarb, chlorpropham, chlorpyrifos, chlorpyrifos-methyl, chlorquinox, chlorsulfuron, chlorthal, chlorthal-dimethyl, chlorthal-monomethyl, chlorthiamid, chlorthiophos, chlozolinate, choline chloride, chromafenozide, cinerin I, cinerin II, cinerins, cinidon-ethyl, cinmethylin, cinosulfuron, ciobutide, cisanilide, cismethrin, clethodim, climbazole, cliodinate, clodinafop, clodinafop-propargyl, cloethocarb, clofencet, clofencet-potassium, clofentezine, clofibric acid, clofop, clofop-isobutyl, clomazone, clomeprop, cloprop, cloproxydim, clopyralid, clopyralid-methyl, clopyralid-olamine, clopyralid-potassium, clopyralid-tris(2-hydroxypropyl)ammonium, cloquintocet, cloquintocet-mexyl, cloransulam, cloransulam-methyl, closantel, clothianidin, clotrimazole, cloxyfonac, cloxyfonac-sodium, CMA, codlelure, colophonate, copper acetate, copper acetoarsenite, copper arsenate, copper carbonate, basic, copper hydroxide, copper naphthenate, copper oleate, copper oxychloride, copper silicate, copper sulfate, copper zinc chromate, coumachlor, coumafuryl, coumaphos, coumatetralyl, coumithoate, coumoxystrobin, CPMC, CPMF, CPPC, credazine, cresol, crimidine, crotamiton, crotoxyphos, crufomate, cryolite, cue-lure, cufraneb, cumyluron, cuprobam, cuprous oxide, curcumenol, cyanamide, cyanatryn, cyanazine, cyanofenphos, cyanophos, cyanthoate, cyantraniliprole, cyazofamid, cybutryne, cyclafuramid, cyclanilide, cyclethrin, cycloate, cycloheximide, cycloprate, cycloprothrin, cyclosulfamuron, cycloxaprid, cycloxydim, cycluron, cyenopyrafen, cyflufenamid, cyflumetofen, cyfluthrin, cyhalofop, cyhalofop-butyl, cyhalothrin, cyhexatin, cymiazole, cymiazole hydrochloride, cymoxanil, cyometrinil, cypendazole, cypermethrin, cyperquat, cyperquat chloride, cyphenothrin, cyprazine, cyprazole, cyproconazole, cyprodinil, cyprofuram, cypromid, cyprosulfamide, cyromazine, cythioate, daimuron, dalapon, dalapon-calcium, dalapon-magnesium, dalapon-sodium, daminozide, dayoutong, dazomet, dazomet-sodium, DBCP, d-camphor, DCIP, DCPTA, DDT, debacarb, decafentin, decarbofuran, dehydroacetic acid, delachlor, deltamethrin, demephion, demephion-O, demephion-S, demeton, demeton-methyl, demeton-O, demeton-O-methyl, demeton-S, demeton-S-methyl, demeton-S-methylsulphon, desmedipham, desmetryn, d-fanshiluquebingjuzhi, diafenthiuron, dialifos, di-allate, diamidafos, diatomaceous earth, diazinon, dibutyl phthalate, dibutyl succinate, dicamba, dicamba-diglycolamine, dicamba-dimethylammonium, dicamba-diolamine, dicamba-isopropylammonium, dicamba-methyl, dicamba-olamine, dicamba-potassium, dicamba-sodium, dicamba-trolamine, dicapthon, dichlobenil, dichlofenthion, dichlofluanid, dichlone, dichloralurea, dichlorbenzuron, dichlorflurenol, dichlorflurenol-methyl, dichlormate, dichlormid, dichlorophen, dichlorprop, dichlorprop-2-ethylhexyl, dichlorprop-butotyl, dichlorprop-dimethylammonium, dichlorprop-ethylammonium, dichlorprop-isoctyl, dichlorprop-methyl, dichlorprop-P, dichlorprop-P-2-ethylhexyl, dichlorprop-P-dimethylammonium, dichlorprop-potassium, dichlorprop-sodium, dichlorvos, dichlozoline, diclobutrazol, diclocymet, diclofop, diclofop-methyl, diclomezine, diclomezine-sodium, dicloran, diclosulam, dicofol, dicoumarol, dicresyl, dicrotophos, dicyclanil, dicyclonon, dieldrin, dienochlor, diethamquat, diethamquat dichloride, diethatyl, diethatyl-ethyl, diethofencarb, dietholate, diethyl pyrocarbonate, diethyltoluamide, difenacoum, difenoconazole, difenopenten, difenopenten-ethyl, difenoxuron, difenzoquat, difenzoquat metilsulfate, difethialone, diflovidazin, diflubenzuron, diflufenican, diflufenzopyr, diflufenzopyr-sodium, diflumetorim, dikegulac, dikegulac-sodium, dilor, dimatif, dimefluthrin, dimefox, dimefuron, dimepiperate, dimetachlone, dimetan, dimethacarb, dimethachlor, dimethametryn, dimethenamid, dimethenamid-P, dimethipin, dimethirimol, dimethoate, dimethomorph, dimethrin, dimethyl carbate, dimethyl phthalate, dimethylvinphos, dimetilan, dimexano, dimidazon, dimoxystrobin, dinex, dinex-diclexine, dingjunezuo, diniconazole, diniconazole-M, dinitramine, dinobuton, dinocap, dinocap-4, dinocap-6, dinocton, dinofenate, dinopenton, dinoprop, dinosam, dinoseb, dinoseb acetate, dinoseb-ammonium, dinoseb-diolamine, dinoseb-sodium, dinoseb-trolamine, dinosulfon, dinotefuran, dinoterb, dinoterb acetate, dinoterbon, diofenolan, dioxabenzofos, dioxacarb, dioxathion, diphacinone, diphacinone-sodium, diphenamid, diphenyl sulfone, diphenylamine, dipropalin, dipropetryn, dipyrithione, diquat, diquat dibromide, disparlure, disul, disulfiram, disulfoton, disul-sodium, ditalimfos, dithianon, dithicrofos, dithioether, dithiopyr, diuron, d-limonene, DMPA, DNOC, DNOC-ammonium, DNOC-potassium, DNOC-sodium, dodemorph, dodemorph acetate, dodemorph benzoate, dodicin, dodicin hydrochloride, dodicin-sodium, dodine, dofenapyn, dominicalure, doramectin, drazoxolon, DSMA, dufulin, EBEP, EBP, ecdysterone, edifenphos, eglinazine, eglinazine-ethyl, emamectin, emamectin benzoate, EMPC, empenthrin, endosulfan, endothal, endothal-diammonium, endothal-dipotassium, endothal-disodium, endothion, endrin, enestroburin, EPN, epocholeone, epofenonane, epoxiconazole, eprinomectin, epronaz, EPTC, erbon, ergocalciferol, erlujixiancaoan, esdépalléthrine, esfenvalerate, esprocarb, etacelasil, etaconazole, etaphos, etem, ethaboxam, ethachlor, ethalfluralin, ethametsulfuron, ethametsulfuron-methyl, ethaprochlor, ethephon, ethidimuron, ethiofencarb, ethiolate, ethion, ethiozin, ethiprole, ethirimol, ethoate-methyl, ethofumesate, ethohexadiol, ethoprophos, ethoxyfen, ethoxyfen-ethyl, ethoxyquin, ethoxysulfuron, ethychlozate, ethyl formate, ethyl α-naphthaleneacetate, ethyl-DDD, ethylene, ethylene dibromide, ethylene dichloride, ethylene oxide, ethylicin, ethylmercury 2,3-dihydroxypropyl mercaptide, ethylmercury acetate, ethylmercury bromide, ethylmercury chloride, ethylmercury phosphate, etinofen, etnipromid, etobenzanid, etofenprox, etoxazole, etridiazole, etrimfos, eugenol, EXD, famoxadone, famphur, fenamidone, fenaminosulf, fenamiphos, fenapanil, fenarimol, fenasulam, fenazaflor, fenazaquin, fenbuconazole, fenbutatin oxide, fenchlorazole, fenchlorazole-ethyl, fenchlorphos, fenclorim, fenethacarb, fenfluthrin, fenfuram, fenhexamid, fenitropan, fenitrothion, fenjuntong, fenobucarb, fenoprop, fenoprop-3-butoxypropyl, fenoprop-butometyl, fenoprop-butotyl, fenoprop-butyl, fenoprop-isoctyl, fenoprop-methyl, fenoprop-potassium, fenothiocarb, fenoxacrim, fenoxanil, fenoxaprop, fenoxaprop-ethyl, fenoxaprop-P, fenoxaprop-P-ethyl, fenoxasulfone, fenoxycarb, fenpiclonil, fenpirithrin, fenpropathrin, fenpropidin, fenpropimorph, fenpyrazamine, fenpyroximate, fenridazon, fenridazon-potassium, fenridazon-propyl, fenson, fensulfothion, fenteracol, fenthiaprop, fenthiaprop-ethyl, fenthion, fenthion-ethyl, fentin, fentin acetate, fentin chloride, fentin hydroxide, fentrazamide, fentrifanil, fenuron, fenuron TCA, fenvalerate, ferbam, ferimzone, ferrous sulfate, fipronil, flamprop, flamprop-isopropyl, flamprop-M, flamprop-methyl, flamprop-M-isopropyl, flamprop-M-methyl, flazasulfuron, flocoumafen, flometoquin, flonicamid, florasulam, fluacrypyrim, fluazifop, fluazifop-butyl, fluazifop-methyl, fluazifop-P, fluazifop-P-butyl, fluazinam, fluazolate, fluazuron, flubendiamide, flubenzimine, flucarbazone, flucarbazone-sodium, flucetosulfuron, fluchloralin, flucofuron, flucycloxuron, flucythrinate, fludioxonil, fluenetil, fluensulfone, flufenacet, flufenerim, flufenican, flufenoxuron, flufenprox, flufenpyr, flufenpyr-ethyl, flufiprole, flumethrin, flumetover, flumetralin, flumetsulam, flumezin, flumiclorac, flumiclorac-pentyl, flumioxazin, flumipropyn, flumorph, fluometuron, fluopicolide, fluopyram, fluorbenside, fluoridamid, fluoroacetamide, fluorodifen, fluoroglycofen, fluoroglycofen-ethyl, fluoroimide, fluoromidine, fluoronitrofen, fluothiuron, fluotrimazole, fluoxastrobin, flupoxam, flupropacil, flupropadine, flupropanate, flupropanate-sodium, flupyradifurone, flupyrsulfuron, flupyrsulfuron-methyl, flupyrsulfuron-methyl-sodium, fluquinconazole, flurazole, flurenol, flurenol-butyl, flurenol-methyl, fluridone, flurochloridone, fluroxypyr, fluroxypyr-butometyl, fluroxypyr-meptyl, flurprimidol, flursulamid, flurtamone, flusilazole, flusulfamide, fluthiacet, fluthiacet-methyl, flutianil, flutolanil, flutriafol, fluvalinate, fluxapyroxad, fluxofenim, folpet, fomesafen, fomesafen-sodium, fonofos, foramsulfuron, forchlorfenuron, formaldehyde, formetanate, formetanate hydrochloride, formothion, formparanate, formparanate hydrochloride, fosamine, fosamine-ammonium, fosetyl, fosetyl-aluminium, fosmethilan, fospirate, fosthiazate, fosthietan, frontalin, fuberidazole, fucaojing, fucaomi, funaihecaoling, fuphenthiourea, furalane, furalaxyl, furamethrin, furametpyr, furathiocarb, furcarbanil, furconazole, furconazole-cis, furethrin, furfural, furilazole, furmecyclox, furophanate, furyloxyfen, gamma-cyhalothrin, gamma-HCH, genit, gibberellic acid, gibberellins, gliftor, glufosinate, glufosinate-ammonium, glufosinate-P, glufosinate-P-ammonium, glufosinate-P-sodium, glyodin, glyoxime, glyphosate, glyphosate-diammonium, glyphosate-dimethylammonium, glyphosate-isopropylammonium, glyphosate-monoammonium, glyphosate-potassium, glyphosate-sesquisodium, glyphosate-trimesium, glyphosine, gossyplure, grandlure, griseofulvin, guazatine, guazatine acetates, halacrinate, halfenprox, halofenozide, halosafen, halosulfuron, halosulfuron-methyl, haloxydine, haloxyfop, haloxyfop-etotyl, haloxyfop-methyl, haloxyfop-P, haloxyfop-P-etotyl, haloxyfop-P-methyl, haloxyfop-sodium, HCH, hemel, hempa, HEOD, heptachlor, heptenophos, heptopargil, heterophos, hexachloroacetone, hexachlorobenzene, hexachlorobutadiene, hexachlorophene, hexaconazole, hexaflumuron, hexaflurate, hexalure, hexamide, hexazinone, hexylthiofos, hexythiazox, HHDN, holosulf, huancaiwo, huangcaoling, huanjunzuo, hydramethylnon, hydrargaphen, hydrated lime, hydrogen cyanide, hydroprene, hymexazol, hyquincarb, IAA, IBA, icaridin, imazalil, imazalil nitrate, imazalil sulfate, imazamethabenz, imazamethabenz-methyl, imazamox, imazamox-ammonium, imazapic, imazapic-ammonium, imazapyr, imazapyr-isopropylammonium, imazaquin, imazaquin-ammonium, imazaquin-methyl, imazaquin-sodium, imazethapyr, imazethapyr-ammonium, imazosulfuron, imibenconazole, imicyafos, imidacloprid, imidaclothiz, iminoctadine, iminoctadine triacetate, iminoctadine trialbesilate, imiprothrin, inabenfide, indanofan, indaziflam, indoxacarb, inezin, iodobonil, iodocarb, iodomethane, iodosulfuron, iodosulfuron-methyl, iodosulfuron-methyl-sodium, iofensulfuron, iofensulfuron-sodium, ioxynil, ioxynil octanoate, ioxynil-lithium, ioxynil-sodium, ipazine, ipconazole, ipfencarbazone, iprobenfos, iprodione, iprovalicarb, iprymidam, ipsdienol, ipsenol, IPSP, isamidofos, isazofos, isobenzan, isocarbamid, isocarbophos, isocil, isodrin, isofenphos, isofenphos-methyl, isolan, isomethiozin, isonoruron, isopolinate, isoprocarb, isopropalin, isoprothiolane, isoproturon, isopyrazam, isopyrimol, isothioate, isotianil, isouron, isovaledione, isoxaben, isoxachlortole, isoxadifen, isoxadifen-ethyl, isoxaflutole, isoxapyrifop, isoxathion, ivermectin, izopamfos, japonilure, japothrins, jasmolin I, jasmolin II, jasmonic acid, jiahuangchongzong, jiajizengxiaolin, jiaxiangjunzhi, jiecaowan, jiecaoxi, jodfenphos, juvenile hormone I, juvenile hormone II, juvenile hormone III, kadethrin, karbutilate, karetazan, karetazan-potassium, kasugamycin, kasugamycin hydrochloride, kejunlin, kelevan, ketospiradox, ketospiradox-potassium, kinetin, kinoprene, kresoxim-methyl, kuicaoxi, lactofen, lambda-cyhalothrin, latilure, lead arsenate, lenacil, lepimectin, leptophos, lindane, lineatin, linuron, lirimfos, litlure, looplure, lufenuron, lvdingjunzhi, lvxiancaolin, lythidathion, MAA, malathion, maleic hydrazide, malonoben, maltodextrin, MAMA, mancopper, mancozeb, mandipropamid, maneb, matrine, mazidox, MCPA, MCPA-2-ethylhexyl, MCPA-butotyl, MCPA-butyl, MCPA-dimethylammonium, MCPA-diolamine, MCPA-ethyl, MCPA-isobutyl, MCPA-isoctyl, MCPA-isopropyl, MCPA-methyl, MCPA-olamine, MCPA-potassium, MCPA-sodium, MCPA-thioethyl, MCPA-trolamine, MCPB, MCPB-ethyl, MCPB-methyl, MCPB-sodium, mebenil, mecarbam, mecarbinzid, mecarphon, mecoprop, mecoprop-2-ethylhexyl, mecoprop-dimethylammonium, mecoprop-diolamine, mecoprop-ethadyl, mecoprop-isoctyl, mecoprop-methyl, mecoprop-P, mecoprop-P-2-ethylhexyl, mecoprop-P-dimethylammonium, mecoprop-P-isobutyl, mecoprop-potassium, mecoprop-P-potassium, mecoprop-sodium, mecoprop-trolamine, medimeform, medinoterb, medinoterb acetate, medlure, mefenacet, mefenpyr, mefenpyr-diethyl, mefluidide, mefluidide-diolamine, mefluidide-potassium, megatomoic acid, menazon, mepanipyrim, meperfluthrin, mephenate, mephosfolan, mepiquat, mepiquat chloride, mepiquat pentaborate, mepronil, meptyldinocap, mercuric chloride, mercuric oxide, mercurous chloride, merphos, mesoprazine, mesosulfuron, mesosulfuron-methyl, mesotrione, mesulfen, mesulfenfos, metaflumizone, metalaxyl, metalaxyl-M, metaldehyde, metam, metam-ammonium, metamifop, metamitron, metam-potassium, metam-sodium, metazachlor, metazosulfuron, metazoxolon, metconazole, metepa, metflurazon, methabenzthiazuron, methacrifos, methalpropalin, methamidophos, methasulfocarb, methazole, methfuroxam, methidathion, methiobencarb, methiocarb, methiopyrisulfuron, methiotepa, methiozolin, methiuron, methocrotophos, methometon, methomyl, methoprene, methoprotryne, methoquin-butyl, methothrin, methoxychlor, methoxyfenozide, methoxyphenone, methyl apholate, methyl bromide, methyl eugenol, methyl iodide, methyl isothiocyanate, methylacetophos, methylchloroform, methyldymron, methylene chloride, methylmercury benzoate, methylmercury dicyandiamide, methylmercury pentachlorophenoxide, methylneodecanamide, metiram, metobenzuron, metobromuron, metofluthrin, metolachlor, metolcarb, metominostrobin, metosulam, metoxadiazone, metoxuron, metrafenone, metribuzin, metsulfovax, metsulfuron, metsulfuron-methyl, mevinphos, mexacarbate, mieshuan, milbemectin, milbemycin oxime, milneb, mipafox, mirex, MNAF, moguchun, molinate, molosultap, monalide, monisouron, monochloroacetic acid, monocrotophos, monolinuron, monosulfuron, monosulfuron-ester, monuron, monuron TCA, morfamquat, morfamquat dichloride, moroxydine, moroxydine hydrochloride, morphothion, morzid, moxidectin, MSMA, muscalure, myclobutanil, myclozolin, N-(ethylmercury)-p-toluenesulphonanilide, nabam, naftalofos, naled, naphthalene, naphthaleneacetamide, naphthalic anhydride, naphthoxyacetic acids, naproanilide, napropamide, naptalam, naptalam-sodium, natamycin, neburon, niclosamide, niclosamide-olamine, nicosulfuron, nicotine, nifluridide, nipyraclofen, nitenpyram, nithiazine, nitralin, nitrapyrin, nitrilacarb, nitrofen, nitrofluorfen, nitrostyrene, nitrothal-isopropyl, norbormide, norflurazon, nornicotine, noruron, novaluron, noviflumuron, nuarimol, OCH, octachlorodipropyl ether, octhilinone, ofurace, omethoate, orbencarb, orfralure, ortho-dichlorobenzene, orthosulfamuron, oryctalure, orysastrobin, oryzalin, osthol, ostramone, oxabetrinil, oxadiargyl, oxadiazon, oxadixyl, oxamate, oxamyl, oxapyrazon, oxapyrazon-dimolamine, oxapyrazon-sodium, oxasulfuron, oxaziclomefone, oxine-copper, oxolinic acid, oxpoconazole, oxpoconazole fumarate, oxycarboxin, oxydemeton-methyl, oxydeprofos, oxydisulfoton, oxyfluorfen, oxymatrine, oxytetracycline, oxytetracycline hydrochloride, paclobutrazol, paichongding, para-dichlorobenzene, parafluron, paraquat, paraquat dichloride, paraquat dimetilsulfate, parathion, parathion-methyl, parinol, pebulate, pefurazoate, pelargonic acid, penconazole, pencycuron, pendimethalin, penflufen, penfluron, penoxsulam, pentachlorophenol, pentanochlor, penthiopyrad, pentmethrin, pentoxazone, perfluidone, permethrin, pethoxamid, phenamacril, phenazine oxide, phenisopham, phenkapton, phenmedipham, phenmedipham-ethyl, phenobenzuron, phenothrin, phenproxide, phenthoate, phenylmercuriurea, phenylmercury acetate, phenylmercury chloride, phenylmercury derivative of pyrocatechol, phenylmercury nitrate, phenylmercury salicylate, phorate, phosacetim, phosalone, phosdiphen, phosfolan, phosfolan-methyl, phosglycin, phosmet, phosnichlor, phosphamidon, phosphine, phosphocarb, phosphorus, phostin, phoxim, phoxim-methyl, phthalide, picloram, picloram-2-ethylhexyl, picloram-isoctyl, picloram-methyl, picloram-olamine, picloram-potassium, picloram-triethylammonium, picloram-tris(2-hydroxypropyl)ammonium, picolinafen, picoxystrobin, pindone, pindone-sodium, pinoxaden, piperalin, piperonyl butoxide, piperonyl cyclonene, piperophos, piproctanyl, piproctanyl bromide, piprotal, pirimetaphos, pirimicarb, pirimioxyphos, pirimiphos-ethyl, pirimiphos-methyl, plifenate, polycarbamate, polyoxins, polyoxorim, polyoxorim-zinc, polythialan, potassium arsenite, potassium azide, potassium cyanate, potassium gibberellate, potassium naphthenate, potassium polysulfide, potassium thiocyanate, potassium α-naphthaleneacetate, pp′-DDT, prallethrin, precocene I, precocene II, precocene III, pretilachlor, primidophos, primisulfuron, primisulfuron-methyl, probenazole, prochloraz, prochloraz-manganese, proclonol, procyazine, procymidone, prodiamine, profenofos, profluazol, profluralin, profluthrin, profoxydim, proglinazine, proglinazine-ethyl, prohexadione, prohexadione-calcium, prohydrojasmon, promacyl, promecarb, prometon, prometryn, promurit, propachlor, propamidine, propamidine dihydrochloride, propamocarb, propamocarb hydrochloride, propanil, propaphos, propaquizafop, propargite, proparthrin, propazine, propetamphos, propham, propiconazole, propineb, propisochlor, propoxur, propoxycarbazone, propoxycarbazone-sodium, propyl isome, propyrisulfuron, propyzamide, proquinazid, prosuler, prosulfalin, prosulfocarb, prosulfuron, prothidathion, prothiocarb, prothiocarb hydrochloride, prothioconazole, prothiofos, prothoate, protrifenbute, proxan, proxan-sodium, prynachlor, pydanon, pymetrozine, pyracarbolid, pyraclofos, pyraclonil, pyraclostrobin, pyraflufen, pyraflufen-ethyl, pyrafluprole, pyramat, pyrametostrobin, pyraoxystrobin, pyrasulfotole, pyrazolynate, pyrazophos, pyrazosulfuron, pyrazosulfuron-ethyl, pyrazothion, pyrazoxyfen, pyresmethrin, pyrethrin I, pyrethrin II, pyrethrins, pyribambenz-isopropyl, pyribambenz-propyl, pyribencarb, pyribenzoxim, pyributicarb, pyriclor, pyridaben, pyridafol, pyridalyl, pyridaphenthion, pyridate, pyridinitril, pyrifenox, pyrifluquinazon, pyriftalid, pyrimethanil, pyrimidifen, pyriminobac, pyriminobac-methyl, pyrimisulfan, pyrimitate, pyrinuron, pyriofenone, pyriprole, pyripropanol, pyriproxyfen, pyrithiobac, pyrithiobac-sodium, pyrolan, pyroquilon, pyroxasulfone, pyroxsulam, pyroxychlor, pyroxyfur, quassia, quinacetol, quinacetol sulfate, quinalphos, quinalphos-methyl, quinazamid, quinclorac, quinconazole, quinmerac, quinoclamine, quinonamid, quinothion, quinoxyfen, quintiofos, quintozene, quizalofop, quizalofop-ethyl, quizalofop-P, quizalofop-P-ethyl, quizalofop-P-tefuryl, quwenzhi, quyingding, rabenzazole, rafoxanide, rebemide, resmethrin, rhodethanil, rhodojaponin-III, ribavirin, rimsulfuron, rotenone, ryania, saflufenacil, saijunmao, saisentong, salicylanilide, sanguinarine, santonin, schradan, scilliroside, sebuthylazine, secbumeton, sedaxane, selamectin, semiamitraz, semiamitraz chloride, sesamex, sesamolin, sethoxydim, shuangjiaancaolin, siduron, siglure, silafluofen, silatrane, silica gel, silthiofam, simazine, simeconazole, simeton, simetryn, sintofen, SMA, S-metolachlor, sodium arsenite, sodium azide, sodium chlorate, sodium fluoride, sodium fluoroacetate, sodium hexafluorosilicate, sodium naphthenate, sodium orthophenylphenoxide, sodium pentachlorophenoxide, sodium polysulfide, sodium thiocyanate, sodium α-naphthaleneacetate, sophamide, spinetoram, spinosad, spirodiclofen, spiromesifen, spirotetramat, spiroxamine, streptomycin, streptomycin sesquisulfate, strychnine, sulcatol, sulcofuron, sulcofuron-sodium, sulcotrione, sulfallate, sulfentrazone, sulfiram, sulfluramid, sulfometuron, sulfometuron-methyl, sulfosulfuron, sulfotep, sulfoxaflor, sulfoxide, sulfoxime, sulfur, sulfuric acid, sulfuryl fluoride, sulglycapin, sulprofos, sultropen, swep, tau-fluvalinate, tavron, tazimcarb, TCA, TCA-ammonium, TCA-calcium, TCA-ethadyl, TCA-magnesium, TCA-sodium, TDE, tebuconazole, tebufenozide, tebufenpyrad, tebufloquin, tebupirimfos, tebutam, tebuthiuron, tecloftalam, tecnazene, tecoram, teflubenzuron, tefluthrin, tefuryltrione, tembotrione, temephos, tepa, TEPP, tepraloxydim, terallethrin, terbacil, terbucarb, terbuchlor, terbufos, terbumeton, terbuthylazine, terbutryn, tetcyclacis, tetrachloroethane, tetrachlorvinphos, tetraconazole, tetradifon, tetrafluron, tetramethrin, tetramethylfluthrin, tetramine, tetranactin, tetrasul, thallium sulfate, thenylchlor, theta-cypermethrin, thiabendazole, thiacloprid, thiadifluor, thiamethoxam, thiapronil, thiazafluron, thiazopyr, thicrofos, thicyofen, thidiazimin, thidiazuron, thiencarbazone, thiencarbazone-methyl, thifensulfuron, thifensulfuron-methyl, thifluzamide, thiobencarb, thiocarboxime, thiochlorfenphim, thiocyclam, thiocyclam hydrochloride, thiocyclam oxalate, thiodiazole-copper, thiodicarb, thiofanox, thiofluoximate, thiohempa, thiomersal, thiometon, thionazin, thiophanate, thiophanate-methyl, thioquinox, thiosemicarbazide, thiosultap, thiosultap-diammonium, thiosultap-disodium, thiosultap-monosodium, thiotepa, thiram, thuringiensin, tiadinil, tiaojiean, tiocarbazil, tioclorim, tioxymid, tirpate, tolclofos-methyl, tolfenpyrad, tolylfluanid, tolylmercury acetate, topramezone, tralkoxydim, tralocythrin, tralomethrin, tralopyril, transfluthrin, transpermethrin, tretamine, triacontanol, triadimefon, triadimenol, triafamone, tri-allate, triamiphos, triapenthenol, triarathene, triarimol, triasulfuron, triazamate, triazbutil, triaziflam, triazophos, triazoxide, tribenuron, tribenuron-methyl, tribufos, tributyltin oxide, tricamba, trichlamide, trichlorfon, trichlormetaphos-3, trichloronat, triclopyr, triclopyr-butotyl, triclopyr-ethyl, triclopyr-triethylammonium, tricyclazole, tridemorph, tridiphane, trietazine, trifenmorph, trifenofos, trifloxystrobin, trifloxysulfuron, trifloxysulfuron-sodium, triflumizole, triflumuron, trifluralin, triflusulfuron, triflusulfuron-methyl, trifop, trifop-methyl, trifopsime, triforine, trihydroxytriazine, trimedlure, trimethacarb, trimeturon, trinexapac, trinexapac-ethyl, triprene, tripropindan, triptolide, tritac, triticonazole, tritosulfuron, trunc-call, uniconazole, uniconazole-P, urbacide, uredepa, valerate, validamycin, valifenalate, valone, vamidothion, vangard, vaniliprole, vernolate, vinclozolin, warfarin, warfarin-potassium, warfarin-sodium, xiaochongliulin, xinjunan, xiwojunan, XMC, xylachlor, xylenols, xylylcarb, yishijing, zarilamid, zeatin, zengxiaoan, zeta-cypermethrin, zinc naphthenate, zinc phosphide, zinc thiazole, zineb, ziram, zolaprofos, zoxamide, zuomihuanglong, α-chlorohydrin, α-ecdysone, α-multistriatin, and α-naphthaleneacetic acid.

8. A composition according to claim 1 further comprising an agriculturally acceptable carrier.

9. A composition according to claim 1 wherein said molecule is in the form of a pesticidally acceptable acid addition salt.

10. A composition according to claim 1 wherein said molecule is in the form of a salt derivative.

11. A composition according to claim 1 wherein said molecule is in the form a hydrate.

12. A composition according to claim 1 wherein said molecule is in the form an ester derivative.

13. A composition according to claim 1 wherein said molecule is in the form a crystal polymorph.

14. A composition according to claim 1 wherein said molecule has a 2H in place of 1H.

15. A composition according to claim 1 wherein said molecule has a 14C in place of a 12C.

16. A composition according to claim 1 further comprising a biopesticide.

17. A composition according to claim 1 further comprising one or more of the following compounds:
(a) 3-(4-chloro-2,6-dimethylphenyl)-4-hydroxy-8-oxa-1-azaspiro[4,5]dec-3-en-2-one;
(b) 3-(4′-chloro-2,4-dimethyl[1,1′-biphenyl]-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4,5]dec-3-en-2-one;
(c) 4-[[(6-chloro-3-pyridinyl)methyl]methylamino]-2(5H)-furanone;
(d) 4-[[(6-chloro-3-pyridinyl)methyl]cyclopropylamino]-2(5H)-furanone;
(e) 3-chloro-N2-[(1 S)-1-methyl-2-(methylsulfonyl)ethyl]-N1-[2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl]-1,2-benzenedicarboxamide;
(f) 2-cyano-N-ethyl-4-fluoro-3-methoxy-benenesulfonamide;
(g) 2-cyano-N-ethyl-3-methoxy-benzenesulfonamide;
(h) 2-cyano-3-difluoromethoxy-N-ethyl-4-fluoro-benzenesulfonamide;
(i) 2-cyano-3-fluoromethoxy-N-ethyl-benzenesulfonamide;
(j) 2-cyano-6-fluoro-3-methoxy-N,N-dimethyl-benzenesulfonamide;
(k) 2-cyano-N-ethyl-6-fluoro-3-methoxy-N-methyl-benzenesulfonamide;
(l) 2-cyano-3-difluoromethoxy-N,N-dimethylbenzenesulfon-amide;
(m) 3-(difluoromethyl)-N-[2-(3,3-dimethylbutyl)phenyl]-1-methyl-1H-pyrazole-4-carboxamide;
(n) N-ethyl-2,2-dimethylpropionamide-2-(2,6-dichloro-α,α,α-trifluoro-p-tolyl) hydrazone;
(o) N-ethyl-2,2-dichloro-1-methylcyclopropane-carboxamide-2-(2,6-dichloro-α, α,α-trifluoro-p-tolyl) hydrazone nicotine;
(p) O-{(E-)-[2-(4-chloro-phenyl)-2-cyano-1-(2-trifluoromethylphenyl)-vinyl]}S-methyl thiocarbonate;
(q) (E)-N1-[(2-chloro-1,3-thiazol-5-ylmethyl)]-N2-cyano-N1-methylacetamidine;
(r) 1-(6-chloropyridin-3-ylmethyl)-7-methyl-8-nitro-1,2,3,5,6,7-hexahydro-imidazo[1,2-a]pyridin-5-ol;
(s) 4-[4-chlorophenyl-(2-butylidine-hydrazono)methyl)]phenyl mesylate; and
(t) N-Ethyl-2,2-dichloro-1-methylcyclopropanecarboxamide-2-(2,6-dichloro-alpha, alpha,alpha-trifluoro-p-tolyl)hydrazone.

18. A composition according to claim 1 further comprising a compound having one or more of the following modes of action: acetylcholinesterase inhibitor; sodium channel modulator; chitin biosynthesis inhibitor; GABA and glutamate-gated chloride channel antagonist; GABA and glutamate-gated chloride channel agonist; acetylcholine receptor agonist; acetylcholine receptor antagonist; MET I inhibitor; Mg-stimulated ATPase inhibitor; nicotinic acetylcholine receptor; Midgut membrane disrupter; oxidative phosphorylation disrupter, and ryanodine receptor (RyRs).

19. A composition according to claim 1 further comprising a seed.

20. A composition according to claim 1 further comprising a seed that has been genetically modified to express one or more specialized traits.

21. A composition according to claim 1 wherein said composition is encapsulated inside, or placed on the surface of, a capsule.

22. A composition according to claim 1 wherein said composition is encapsulated inside, or placed on the surface of, a capsule, wherein said capsule has a diameter of about 100-900 nanometers or about 10-900 microns.