Docket Number EPA-HQ-OPP-2014-0670 

www.regulations.gov 

1-Methylcyclopropene 

(1-MCP) 

PC Code: 224459 

Registration Review Final Work Plan 

Approved by: 

Date: 

March 201 6 

Case 6075 

Robert McNally, Director 

Biopesticides and 

Pollution Prevention Division 
INTRODUCTION 

This is the Environmental Protection Agency's (EPA or the Agency) Final Work Plan (FWP) for 

the registration review of 1-methylcyclopropene (1-MCP). This work plan addresses public 

comments received concerning the Preliminary Work Plan (PWP), which was posted in the 1-

MCP registration review docket (EPA-HQ-OPP-2014-0670). 1-MCP is currently registered for 

use as a post-harvest tool for counteracting the undesirable effects of ethylene on harvested 

fruits, vegetables, and ornamental (such as cut flowers) during transport and storage, and for preharvest use on growing crops and ornamentals. 

The Agency is implementing the registration review program pursuant to Section 3(g) of the 

Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), and will review each registered 

pesticide every 15 years to determine whether it continues to meet the FIFRA standard for 

registration. Changes in science, public policy, and pesticide use practices occur over time. The 

registration review program is intended to make sure that, as the ability to assess risk evolves and 

as policies and practices change, all registered pesticides continue to meet the statutory standard. 

The public phase of registration review begins when the initial docket is opened for each case. 

Information on this program is provided on the Agency's website. 1 

The FWP begins with any updates since the PWP was issued. Next is a summary of substantive 

comments received during the public comment period for the PWP concerning anticipated data 

needs, expected risk assessments, or the estimated timeline identified in the PWP, and a 

summary of the Agency's responses to those comments. This section is followed by registration 

review planned data needs, risk assessments expected to be conducted, and the projected 

registration review timeline for 1-MCP. Lastly, there is a discussion of next steps. 

UPDATES SINCE THE PWP WAS ISSUED 

There are no additional updates on 1-MCP since the issuance of the PWP. 

SUMMARY OF COMMENTS AND AGENCY RESPONSES 

During the 60-day public comment period on the 1-MCP PWP, which opened on October 2, 

2015, and closed on December 1, 2015, the Agency received one comment concerning this case. 

This sole comment was submitted by Laura Grunenfelder, Northwest Horticultural Council, in 

support of the continued registration of 1-MCP as a "critical tool for the tree fruit industry." 

PLANNED DATA NEEDS 

The planned data needs have not changed from what was included in the 1-MCP PWP. 

1 http://www.epa. gov/oppsnd I /registration review/ 

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RISK ASSESSMENTS FOR REGISTRATION REVIEW 

As stated in the PWP, no data gaps (anticipated data needs) for 1-MCP have been identified. The 

most recent comprehensive risk assessment for 1-MCP was completed February 21, 2001, in 

support of a request to establish an exemption from the requirement of a tolerance for residues of 

1-MCP on all food commodities. Because there are no data gaps for 1-MCP or anticipated data 

needs, and no additional information has been received on this biochemical since this most 

recent risk assessment, the Agency does not anticipate the need to conduct a new risk assessment 

during registration review. 

TIMELINE 

EPA has created the following estimated time line for the completion of the 1-MCP registration 

review in Table 1, below. This projected timeline has not changed since the PWP. 

Table 1: Registration Review for 1-Methylcyclopropene (1-MCP) -

Projected Registration Review Timeline 

Activities Estimated MonthlY ear 

Openin2 the Docket 

Open Docket and 60-Day Public Comment Period October 2015 

Close Public Comment Period December 20 15 

Case Development 

Issue Final Work Plan March 2016 

Issue Data Call-in N/A 

Data Submission N/A 

Open 30-Day Public Comment Period for Draft Risk Assessments N/A 

Close Public Comment Period NIA 

Registration Review Decision 

Open 60-Day Public Comment Period for Proposed Registration Review September 2016 

Decision 

Close Public Comment Period November 2016 

Final Decision March 2017 

*Estimated Total (years) 1 year and 5 months 

* This schedule is subject to revision should unforeseen issues arise dunng the regtstrahon revtew process. In the 

event an issue arises, such as the failure to acquire an EDSP exemption, an amended Final Work Plan will be 

issued at that time that will set forth a new time line and, if applicable, any new data requirements will be included 

in the amended document and a Data Call-In Notice will be issued. 

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NEXT STEPS 

The Agency plans to issue a Proposed Registration Review Decision for this case in September, 

201 6. At that time, a 60-day public comment period will be opened to accept comments on the 

Proposed Decision. 

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